2

AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO EA?AeIIEIAI? ?i.aeaae.I.Ae.NO?AAEANEA

Cieioa?ueiaa-Aiae???aa

Iaoae?y A?oai?aia

OAeE 616 — 008.6
— 0.92 — 07 — 08

A?ia?iia?eueiee neiae?ii

(iaoai?cie ?icaeoeo, ee?i?ei-eaai?aoi?ia ae?aaiinoeea,

i?eioeeie e?eoaaiiy)

14.01.12 – ?aaiaoieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaeanueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

IAOEIA? EIINOEUeOAIOE:

aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeaiei Aieiaeeie? Ieeieaeiae/,
aee?aeoi?, caaiaeoaa/ aiaeaeieaiiy ee?i?/ii? ?aaiaoieiai? ?inoeoooo
ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea AII Oe?a?ie.

aeieoi? iaaee/ieo iaoe, i?ioani? sseeiaiei Ieaia Ieaenaiae?iaia,
caaiaeoaa/ eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia oa oa?ai??
Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo IIC Oe?a?ie.

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?iaioiee ?eeyo Ia?iy
A?eai?iaia, caaiaeoaa/ a?aeae?eaiiy caoai?thaaiue i?iea?aeo oa aaae
na?oey ?inoeoooo ea?ae?ieia?? ?i.aeaae.I.Ae.No?aaeanea AII Oe?a?ie.

aeieoi? iaaee/ieo iaoe, i?ioani? Aaaei?ia Eiaeiy sseiaia, i?ioani?
eaoaae?e n?iaeii? iaaeeoeeie Ee?anueei? iaaee/ii? aeaaeaii?
i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie.

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?iaioiee Aa?aneiaiei Na?aie
?aaiiae/, canooiiee aee?aeoi?a Oe?a?inueeiai iaoeiai-aeineiaeiiai
iinoeoooo o?aaiaoieiai? oa i?oiiaaei? IIC Oe?a?ie.

I?IA?AeIA ONOAIIAA:

Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie, eaoaae?a
ainiioaeueii? oa?aii? ?2.

Caoeno a?aeaoaeaoueny “ 25 “ o?aaiy 1999 ?. i 10-00 aiaeei?
ia can?aeaii? niaoe?aeiciaaii? a/aii? ?aaee Ae 26.616.01 i?e ?inoeoooi
ea?aeiieiai? ?i.aeaae.I.Ae.No?aaeanea AII Oe?a?ie ca aae?anith: 252151,
i.Ee?a, aoe.Ia?iaeiiai Iiie/aiiy, 5.

C aeena?oaoei?th iiaeia iciaeiieoeny a aiaeiioaoei ?inoeoooo
ea?aeiieiai? ii.aeaae.I.Ae.No?aaeanea AII Oe?a?ie ca aae?anith: i.Ee?a,
aoe.Ia?iaeiiai Iiie/aiiy, 5.

Aaoi?aoa?ao ?ic?neaiee “ 24 “ ea?oiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee
Aeaye N.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?iciianthaeaeai?noue ?aaiaoe/ieo caoai?thaaiue
aeineoue aaeeea ? yaey?oueny iaei??th c iniiaieo i?e/ei oei/aniai?
iai?aoeacaeaoiino? ? ?aii ianooiath/i? ?iaae?aeiino?. Oai?? ia
?aaiaoe/i? caoai?thaaiiy neeaaeathoue a?ae 12 aei 25% an?o in?a,
ui caa?oathoueny ca aeiiiiiaith a iaaee/i? onoaiiae
(E.?.Aiiaaieainueea,1989).

A?aeiii, ui iaeiei c naieo iioe?aieo neiae?ii?a ?aaiaoe/ieo
caoai?thaaiue ? noaeiaiaee. I?e a?eueoino? ?aaiaoe/ieo caoai?thaaiue
niinoa??aa?oueny iaiaaeaiiy ?ooeeaino? noaeiaa, yea i?iaieo?oueny
caiaeueiei aai aeeno?io?/iei i?ioeanii, ? a?aeia?aaeo?oueny o ae?aaiic?
ye ooieoe?iiaeueia iaaeinoaoi?noue ??ciiai nooiaiy. A i?ioeaaao
oeueiio, o aeayeeo oai?eo niinoa??aa?oueny oae caaia “?icoeoai?noue”
noaeia?a, i?aeaeuaia ieanoe/i?noue. “Oaiiiai” ca?eueoaii? ?ooeeaino?
noaeia?a aoa a?aeiiee aeineoue aeaaii, aea e aein? iaia? /?oeiai
oyaeaiiy, /e ? oaea a?ia??ooeea?noue iciaeith iaaeeeoeiai? ae?aaeaiino?
?ooeeaino?, /e aiia ?, oae caaiith, “aa?oiath iaaeath ii?ie”.

Noaeiaiaa a?ia??ooeea?noue ? iciaeith, yea o iianyeaeaii?e iaaee/i?e
i?aeoeoe? /anoi caeeoa?oueny iaiii?/aiith. Iaeiae, oi?iaeiaae o?ueio
inoaii?o aeanyoee?oue iieacaii, ui aiia iiaea neoaeeoe iioaioe?eiei
iaoiaaiiei oaeoi?ii (P.Beigton o ni?aaao., 1983; I.P. Camus o ni?aaao.,
1987; E.E. Aiiaaieaineay o ni?aaao.; I.Ondrasik, 1984; C.N.A.Rajapakse,
1987) ? oiio ia oe?e i?iaeai? aoei cina?aaeaeaii a?eueoa oaaae. Aia?oa
oa?i?i “a?ia?iia?eueiee neiae?ii” (AIN) aoa caii/aoeiaaiee I.A.Kirk o
ni?aaao. o 1967?. ? ca?ac i?ae iei ?icoi?thoue ca?eueoaiiy aiie?ooaee
?oo?a iaeiiai aai e?eueeio noaeia?a a ii?aeiaii? c ??cieie ci?iaie c
aieo iii?ii-?ooiai? nenoaie.

Iaeaea an? iaaaaaoi/eneaii? iaoeia? aeine?aeaeaiiy a aaeoc? AIN
i?iaaaeai? ca ei?aeiiii. I?aoeyie aiae?enueeeo a/aieo aoea c?iaeaia
ni?iaa nenoaiaoecoaaoe aieiai? ee?ie/i? i?iyae caoai?thaaiiy (P.Beighton
oa F.Horan,1969), /anueeith oeieith aea/athoueny ieoaiiy ai?aeai?ieia??
AIN (I.Iiae?aoee, 1986, 1989), o?aioeocuee? aaoi?e ina?oeththoue /anoa
ii?aeiaiiy AIN c aiiiaeueieie ci?iaie na?oeaai-noaeeiii? nenoaie
(T.P.Petitalot o ni?aaao., 1987). A?o/eciyieo ?ia?o, i?enay/aieo
aea/aiith AIN, ie a e?oa?aoo?? ia ciaeoee, iacaaaeath/e ia oa, ui oey
iiaa iicieia?/ia oi?ia io?oe?eii aaaaeaia o 1985 ?ioe? aei ?iai/i?
eeaneo?eaoe?? oai?ia noaeia?a ii?yae c e?aua aea/aieie oai?iaaie
niieo/ii? oeaieie — neiae?ii Aea?na-Aeaieina, oai?iaa Ia?oaia
(A.I.Ianiiiaa o ni?aaao.,1997). Iaaeinoaoiy aea/ai?noue oe??? “iieiaei?”
iicieia?/ii? oi?ie, a oaeiae a?aenooi?noue ioae?eaoe?e ia oeth oaio o
ian a e?a?i? yaeythoueny, ia iao iiaeyae, iniiaiith i?e/eiith, /a?ac yeo
o iianyeaeaii?e iaaee/i?e i?aeoeoe? AIN ia ae?aaiinoo?oueny ia o?eueee
iaoeie e?ea?yie-oa?aiaaoaie, aea oaeiae ? ?aaiaoieiaaie.

Iaeiae, aea/aiiy caei?aeiiieie a/aieie AIN oi?iaeiaae o?ueio inoaii?o
aeanyoee?oue iieacaei, ui noaeiaiaa a?ia?iia?euei?noue iiaea neoaeeoe
iioaioe?eiei iaoiaaiiei oaeoi?ii ia o?eueee uiaei iii?ii-?ooiaiai
aia?aoo, aea e iaoiiaeth? iiyao oaeiae iicanoaeiaieo i?iya?a, iaea?eueo
aaaeeeie c yeeo ? na?oeaai-noaeeii? (a?eoi??, neieiiaeuei? noaie,
a?ae?eae oi?ae, i?ieaine eeaiai?a, aae aei ?aioiai? nia?o?).
A?aoiaoth/e oa, ui AIN ia? ?yae noiooiio o?aaeaiue aioo?ioiio i?aaiia,
eiei caei?aeiiieo iaoeiaeo aeine?aeaeaiue a oe?e aaeoc? cia/ii
iioe?eeinue. Iaeiae, iacaaaeath/e ia oea, ia nueiaiaeiyoi?e aeaiue
ao?ieia?y oa iaoiaaiac caoai?thaaiiy oi/ii ia anoaiiaeai?, ee?i?/i?
i?iyae aea/ai? iaaeinoaoiuei, ieoaiiy niaaeeiaino? iaiaeiicia/i?,
i?io?eaeoeea oa e?eoaaiiy ia ?ic?iaeaii ia o?eueee o ian a e?a?i?, aea
oaeiae ? ca ei?aeiiii.

Oaeei /eiii, aaaaoi ieoaiue ye oai?aoe/iiai oae ? i?aeoe/iiai ieaio
i?e aea/aii? a?ia?iia?eueiino? noaeia?a caeeoathoueny iaae??oaieie.
A?aoiaoth/e aeineoue aenieo ?iciianthaeaeai?noue aeaiiai caoai?iaaiiy ?
eiai oneeaaeiaiue a iiioeyoe??, iaiao?aeii ua ?ac i?aee?aneeoe
aaaeeea?noue ? iaiao?aei?noue iiaeaeueoeo aeine?aeaeaiue c iaoith
iciaeiieaiiy c iei oe?ieiai eiea e?ea??a-ee?i?oeeno?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Ia?aiee iai?yiie
aeineiaeaeaiue niiaiaaea? c aeineiaeaeaiiyie, yei i?iaiaeyoueny ia
eaoaae?i i?iiaaeaaoeee aioo?ioiio oai?ia i oa?aii? Iaeanueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo. Io?eiaii ?acoeueoaoe ?
neeaaeiaith /anoeiith caeeth/iiai caioo eaoaae?e i?i iaoeiao-aeine?aeio
?iaioo 1995-1998 ?.? ca oaiith: “Ee?i?ei-aenia?aiaioaeueia ?ic?iaea
iaoiae?a a?aeiiaethaaeueiiai e?eoaaiiy ia iniia? coaoaai-a?eiaeo
iniaeeainoae ?aaiaoe/ieo caoai?thaaiue” (?aea?ae?a?no?aoe?? 0193
U023668).

Iaoa ? caaaeaiiy aeineiaeaeaiiy. Ia iniia? aea/aiiy iaoiaaiaco ?
ee?i?/ieo aa??aio?a ia?aa?ao aiia?iiaieueiiai neiae?iio ?ic?iaeoe
e?eoa??? eiai ae?aaiinoeee oa i?eioeeie e?eoaaiiy.

A?aeiia?aeii aei iinoaaeaii? iaoe ae??ooaaeenue ianooii? caaaeaiiy:

1.Aea/eoe ?iciianthaeaeai?noue AIN a iiioeyoe?? aei?ineiai
ianaeaiiy i?aaeaiiiai ?aa?iio Oe?a?ie.

2.I?iaanoe ee?i?ei-aaiaieia?/iee aiae?c oai?eo ia AIN
i?iaaiae?a oa ?o ?iaee/?a.

3.I?iaanoe iiooe a?aeiia?aeieo aaiaoe/ieo ia?ea??a (HLA- ?
DR-oeioaaiiy).

4.Aea/eoe iniaeeaino? iaoaaie?cio niieo/ii? oeaieie ? a?aeiia?aei? ?i
a?io?i?/i? oa ?ioiieia?/i? i?iyae.

5. Aea/eoe aa?iaioe ee?i?/iiai ia?aa?ao AIN, eiai noaeiaia? ?
iicanoaeiaia? i?iyae.

6. ?ic?iaeoe ? nenoaiaoecoaaoe e?eoa??? ee?i?/ii?, ee?i?ei-eaai?aoi?ii?
oa ?ino?oiaioaeueii? ae?aaiinoeee AIN.

7. ?ic?iaeoe i?aeoiaee aei e?eoaaiiy AIN.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoaoia. Aia?oa aea/aia
?iciianthaeaeai?noue AIN a iiioeyoe?? aei?ineiai ianaeaiiy i?aaeaiiiai
?aa?iio Oe?a?ie.

Aia?oa aecia/ai? iaoiaaiaoe/i? iaoai?cie ii?ooaiiy iaoaaie?cio
iacaio?iaeueieo no?oeoo?, iaoiiaethth/eo caaaeueio niieo/iioeaieiio
aeenieac?th, cie?aia aea/ai? ni?aa?aeiioaiiy i?ae aieiaieie aea?eaaoaie
eieaaaio (ienei?ie?i), oa?iaioiith aeoeai?noth (eieaaaiaca,aeanoaca,
eene? oa iaeo?aeuei? i?ioaace) oa ?ia?a?oi?iith aeoeai?noth.

Iiaecio ?iaioe noaiiaeoue aea/aiy iaoai?ciia ii?ooaiue
eeneioii-eoaeiiai aaeaino o oai?eo ia AIN ? iaa?oiooaaiiy aca?iica`yceo
i?ae ieie ? oi?ioaaiiyi “iaiiaiioe?iieo” niieo/iioeaieiieo no?oeoo?,
ca`ycaieo ia?aaaaeii c “aeniaaeaiiyi” i?ioa?iieo noano?ao?a iacaio?ie,
ui, a naith /a?ao, ? iaoiiaeth? iniiai? ee?i?/i? i?iyae caoai?thaaiiy.

Anoaiiaeaiee oei oniaaeeoaaiiy AIN, aia?oa aecia/ai? eiai aaiaoe/i?
ia?ea?e (ii HLA- ? DR-oeioaaiith).

Aecia/ai? ??ci? ee?i?/i? oi?ie caoai?thaaiiy, nooi?iue eiai o?aaeaiiino?
oa ?iciianthaeaeaiiino? ? cai?iiiiiaai? nenoaiaoeciaai? ee?i?/i?,
eaai?aoi?i? oa ?ino?oiaioaeuei? e?eoa??? aeey ae?aaiinoeee AIN.

Iiaei a ?iaio? ? iaa?oioiaaia oa?ai?y aeaiiai caoai?thaaiiy c
aeei?enoaiiyi iaaeeeaiaioicieo oa oiciioa?aiaaoe/ieo iaoiaeia eieoaaiiy.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iaea?aeai? aeai? uiaei
?iciianthaeaeaiino? AIN aeiiiiaaathoue aecia/aiith aeaiii? iaoieia?? a
caaaeuei?e no?oeoo?? ?aaiaoe/ieo caoai?thaaiue, a nenoaiaoecaoe?y
aea/aieo ee?i?/ieo, eaai?aoi?ieo, aaiaoe/ieo oa ?ino?oiaioaeueieo
e?eoa???a ae?aaiinoeee iioei?cothoue ieoaiiy uiaei ?aiiuei? ae?aaiinoeee
oeueiai caoai?thaaiiy.

Aecia/aiiy ??cieo ee?i?/ieo oi?i AIN aeicaiey? nai?/anii ae?aaiinooaaoe
ia o?eueee o?aaeaiiy c aieo iii?ii-?ooiaiai aia?aoo , aea oaeiae ? eiai
a?noea?aeueii i?iyae c aieo ?ioeo nenoai ?, ianaiia?aae,
na?oeaai-noaeeiii? nenoaie.

Aea/aiiy iaoaiicio aiioiii/ieo ii?ooaiue iaoaaieicio niieo/ii? oeaieie
aeicaieeei ?ic?iaeoe i?ia?aio iaoiaaiaoe/iiai e?eoaaiiy oai?eo c AIN, a
aecia/aiiy ?icieo ee?i?/ieo oi?i caoai?thaaiiy — aeeoa?aioeieii
eiiieaene neiioiiaoe/ii? oa?ai??.

Cai?iiiiiaaiee niin?a ae?aaiinoeee a?ia??ooeeaino? ye ee?i?/ii? iciaee
iiaea aooe aeei?enoaiee i?aeoe/ieie e?ea?yie ia?oiai eaioethaa
(ae?eueie/i? oa?aiaaoe, n?iaei? e?ea??), a nenoaiaoeciaai? e?eoa??? AIN
ye caoai?thaaiiy ? ai?iaaaeaeaia e?eoaaiiy – aeey e?ea??a oe?ieiai
i?io?eth ?, ianaiia?aae, ?aaiaoieia?a (noaoe?iia?ia niinoa?aaeaiiy).

Ai?iaaaeaeaiiy ?acoeueoaoia aeineiaeaeaiue a i?aeoeeo. ?ic?iaeai?
iaoiaee ae?aaiinoeee ? e?eoaaiiy canoiniaothoueny a ea?ae?ieia?/iiio oa
?aaiaoieia?/iiio a?aeae?eaiiyo iinueeiai ea?aeii?aaiaoieiai/iiai oeaio?o
ii.i?io.I.I.I?iaeiaa i.Iaeane, o oa?aiaaoe/iiio a?aeae?eaii? cae?cie/ii?
e?ea?i? i.Iaeane.

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeai? a o/aiaee i?ioean ia eaoaae??
i?iiaaeaaoeee aioo??oi?o oai?ia ? oa?ai?? Iaeanueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaaaeaii eeiii/ia
ianoaaeaiiy oai?eo ia AIN oa ?o ?iaee/ia (i?e aea/aiii iaoieiai/ieo
iciae c aieo ia?aiai? nenoaie oa i?aaio ci?o – ?acii c ia?aiiaoieiaii oa
ieoeinoii), iiaeai? a a?oie aeey ?icieo eiiieaenia eieoaaiiy,
ne?eiiiaiaa iiioeyoeieia ianoaaeaiiy. I?iaaaeaii aeeoa?aioeieia
eieoaaiiy /ioe?ueio a?oi oai?eo. Ocaaaeueiaii oa noaoenoe/ii ia?iaeaii
?acoeueoaoe aeineiaeaeaiiy, iiaeaioiaeaii iaoeiai aeaii aei ioaeieaoei?
i ?aoeiiiaeicaoi?nueei? i?iiiceoei?. Aiioiii/ii aeineiaeaeaiiy c
iaoaaieicio niieo/ii? oeaieie oa eeneioii-eoaeii? ?iaiiaaae i?iaaaeaii
?acii ic niia?iaioieeaie eaai?aoi?i? Iaeanueeiai iaoeiai-aeine?aeiiai
iinoeoooo noiiaoieiai? (ea?iaiee – aeieoi? iaae.iaoe, i?ioani? Iaoiiiaa
A.I.), iiioiiaaiaoe/ii aeineiaeaeaiiy – ?acii ic niia?iaioieeaie
eaai?aoi?i? eaoaae?e i?iiaaeaaoeee aioo?ioiio oai?ia oa oa?aii?
Iaeanueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aeaeeny ia ?anioaeieainueeiio neiiicioii ?aaiaoieia?a
(aa?acaiue,1995); YI Eiia?an? Na?oiai? oaaea?aoe?? oe?a?inueeeo
e?ea?nueeeo oiaa?enoa (aa?anaiue,1996); ia can?aeaii? Iaeanueei? ni?eee
?aaiaoieia?a (n?/aiue,1997); Iaeanueei? ni?eee ea?ae?ieia?a
(o?aaaiue,1997); can?aeaii? eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia ?
oa?ai?? iaae?ao?e/iiai oa noiiaoieia?/iiai oaeoeueoao?a Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (aeiaoaiue,1996).

?iaioo ai?iaiaaii ia caniaeaiii eaoaae?e i?iiaaeaaoeee aioo?ioiio
oai?iai i oa?aii? Iaeanueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo, ia
niieueiiio caniaeaiii iinoeooonueei? i?iaeaiii? eiiini? oa eaoaae?e
i?iiaaeaaoeee aioo??oiio oai?iai i oa?aii? Iaeanueeiai aea?aeaaiiai
iaaee/iiai oiiaa?neoaoo, ia niieueiiio caniaeaiii aiaeaeieaiue oai?ia
iiiea?aeo oa aaae na?oey, eeiii/ii? aiioiii? i eeiii/ii? iioiieiai?
?inoeoooo ea?aeiieiai? ii.aeaae.I.Ae.No?aaeanea AII Oe?a?ie.

Ioaeieaoei?. Ca oaiith aeena?oaoe?? iioae?eiaaii 40 iaoeiaeo ?ia?o: 17
noaoae o aeo?iaeao, caoaa?aeaeaieo AAEii Oe?a?ie (oni caiinoieii),
oa 23 oace (c ieo 16 naiino?eii), 1 ?aoe?iiae?caoi?nueea
i?iiiceoe?y (naiino?eii).

No?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 260 noi??ieao
eiii’thoa?iiai oaenoo ? neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e,
naie ?icae?e?a iniaenoeo aeine?aeaeaiue, iaaiai?thaaiiy io?eiaieo
?acoeueoao?a, aeniiae?a oa ia?ae?eo aeei?enoaieo e?oa?aoo?ieo aeaea?ae
(131 a?o/eciyieo ? 172 caei?aeiiieo aaoi??a). ?iaioa ?ethno?iaaia 48
oaaeeoeyie ? 19 iaethieaie.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

C iaoith aeyaeaiiy ?iciianthaeaeaiino? a?ia?iia?eueiiai neiae?iio
i?iaaaeaii ne?ei?iaiaa ianoaaeaiiy 1060 in?a (a iniiaiiio nooaeaioe
iaaee/iiai oi?aa?neoaoo i.Iaeane, aeii?eceaieee oa iieiae? ?ia?oieee) o
na?aaeiueiio a?oe? 21,0 + 0,6 ?ie?a, /ieia?e?a — 530 ? ae?iie — 530.
Aeey aecia/aiiy AIN aoee aeei?enoai? cai?iiiiiaai? iaie e?eoa??? a?ia?-
?ooeeaino? noaeia?a (?aoe?iiae?caoi?nueea ai?iaaaeaeaiiy ?24 a?ae 19
o?aaiy 1996?.), ye? ia a?aei?io a?ae oi?o?eiaaieo e?eoa???a ii
P.Beighton ? F.Horan ia?aaeaa/athoue iaeii/anio ioe?ieo ye ?ooeeaino?
oae ? ?iciianthaeaeaiino? o?aaeaiino? noaeia?a o ie?aieo iaoe??io?a.
Nooi?noue iaoiai iaoiaeo iieyaa? a ioe?ioe? nooiaiy caeiaiiy a ia?oeo
iaoaea?iioaeaiaiaeo noaeiaao iaio ?oe oa caeiaiiy i?e iaoee? ooeoaa i?e
o?eniaaieo eie?iieo noaeiaao.

A?aeiii, ui o?c?ieia?/ia ?ooeea?noue ia?oeo iaoaea?iioaeaiaiaeo noaeia?a
i?e aeoeaiiio ? ianeaiiio caeiaii? ia noi?iaiaeaeo?oueny aeioeeii
aaeeeiai iaeueoey aei aeieiiii? iiaa?oi? ia?aaeie?//y, a i?e iaoee?
ooeoaa c oiiae o?eniaaieo eie?iieo noaeia?a aeioee aei i?aeeiae
aeinyaa?oueny eeoa e?i/eeaie iaeueoe?a ?oe.

I?e eaaeiio nooiai? a?ia?iia?eueiino? noaeia?a ianeaia caeiaiiy 1
iaeueoey aei aeieiiii? iiaa?oi? ia?aaeie?//y noi?iaiaeaeo?oueny aeioeeii
aei iiaa?oi? ia?aaeie?//y, a iaoee ooeoaa aia?aae i?e o?eniaaieo
eie?iieo noaeiaao — aeinyaiaiiyi i?aeeiae iaeueoeyie (iieiaeiith
aeieii?).

I?e ae?aaeaiiio nooiai? a?ia?iia?eueiino? noaeia?a aaeeeee iaeaoeue ?oee
i?eaiaeeoueny aei aeieiiii? iiaa?oi? ia?aaeie?//y ? ca iueiai, a iaoee
ooeoaa aia?aae i?e o?eniaaieo eie?iieo noaeiaao caaacia/o? aeinyaiaiiy
i?aeeiae an??th aeieiiath.

Ae?aaiic a?ia?iia?eueiiai neiae?iio aenoaaeyany o aeiaaeeao ii?aeiaiiy
??ciiai nooiaiy a?ia?iia?eueiino? noaeia?a c ?ioeie i?iyaaie o?aaeaiiy
iii?ii-?ooeeaiai aia?aoo (neie?ic, inoaioiiae?ic, cae/i? i?aeaeaeoe,
caeee? ?icoyaiaiiy nooiaeeeie, ia?nenooth/? neiia?oe oa ?i.), a oaeiae c
?ioeie eieae?caoe?yie o?aaeaiiy niieo/ii? oeaieie (eeaiaiiee aia?ao
na?oey, aa?eeicia ?icoe?aiiy aai, iaoieia?y i?aaio ci?o oa ?i.).

Aeaoaeueiiio ianoaaeaiith c aeei?enoaiiyi caaaeueiiee?i?/iiai
aeine?aeaeaiiy, a oaeiae niaoe?aeueieo eaai?aoi?ii-?ino?oiaioaeueieo
iaoiae?a aoei i?aeaeaii 130 oai?eo ia AIN. Aea/aiiy eeiii/ieo iieacieeia
i?iaiaeeeiny iaoiaeii iieooaaiiy i ianoaaeaiiy oai?iai, i?e aea/aiii
iaoieiai/ieo iciae c aieo ia?aiai? nenoaie i i?aaio ci?o – ca
aeiiiiiaith ia?aiiaoieiaa i ieoeinoa.

C aiioiii/ieo iieacieeia ca aeiiiiiaith niaeo?ioioiiao?a aea/aeeny ci?no
ienei?ie?io, a?eea e?ia?, aeoeai?noue eieaaaiace, aeanoace, iaeo?aeueieo
i?ioaac, aeoeai?noue eeneeo i?ioaac (Eaoainei Ae), ?ia?aeoi?ii?
aeoeaiino? e?iai.

Oaeiae aea/aany noai eeneioii-eoaeiiai aiiainoaco, iniiaaiee ia
aecia/aii? eiiiainaoi?ieo iai?iieo iaoai?ci?a, iai?aaeaieo ia
i?aeo?eiaiiy ?I, ye? ?icaeaathoueny aaciina?aaeiuei o oeaieiao oa
??aeeiao i?aai?cio (Ae.I.Iaeueie/oe, A.A.Iaoiiiaa,1997). Aea/aeeny
ianooiii iieacieee: ciino ii?oaaoa, ienaeaoeaoaoa, eaeoaoa, iaeaoa,
ciino oiieia oa aeenoeueoiaeia, aeoeaiinoue IAAe-caeaaeii?
iaeaoaeaaiae?iaaiace, o?oeoiciaeeoinoioace (ca caaaeueiii?eeiyoeie
iaoiaeeeaie).

Ie??i oiai, o 30 ii??aiyieo ii noao? ? a?eo caei?iaeo in?a aoei
i?iaaaeaii aiaeia?/ia a?io?i?/ia aeine?aeaeaiiy aeey aecia/aiiy
na?aaeiuei-ii?iaeueieo aaee/ei aeine?aeaeoaaeueieo iieaciee?a.

O 52 i?iaaiae?a oa 78 ?iaee/?a I nooiaith nii??aeiaiino? (aaoueee,
ae?oe, n?ane) i?iaiaeeeiny ee?i?ei-aaiaieia?/ia ianoaaeaiiy ? aiae?c
oeio oniaaeeoaaiiy (aeii?iaioiee /e ?aoeaneaiee) c aecia/aiiyi ??aiy
iaiao?aioiino? a?aeiia?aeiiai aaia. Aeey oeueiai aeei?enoiaoaaany can?a
aecia/aiiy oeio oniaaeeoaaiiy i?e iaiiai?e aaiaieia?/i?e ?ioi?iaoe??,
cai?iiiiiaaiee A.I.Ne?ioeeiei o ni?aaao. (1973).

C iaoith aeyaeaiiy anioe?aoeaieo ca`yce?a c aioeaaiaie aieiaiiai
eiiieaeno a?noinoi?niino? nenoaie HLA a aeine?aei?e a?oi? i?iaiaeeany
iiooe oaiioeiiaeo ia?ea??a noeeueiino? aei ?icaeoeo oeueiai
caoai?thaaiiy. Aeey HLA ? DR-oeioaaiiy canoinoaaee noaiaea?oiee
i?e?ie?ioioiene/iee oano (TH.I.Ca?aoeeay,1983).

Eiiieaenia ?ino?oiaioaeueia ianoaaeaiiy oai?eo i?iaiaeeeiny c
aeeth/aiiyi ?yaeo caaaeueiii?eeiyoeo cania?a aeine?aeaeaiiy
(aeaeo?iea?ae?ia?ao?y, ?aioaaiia?ao?y o?aaaoiiai noiaia, aeine?aeaeaiy
i?aaio ci?o, ?o/ia ? noaiiaa aeeiaiiiao??y), a oaeiae niaoe?aeueieo
iaoiaeia — aoiea?ae?ieia?/ia ianoaaeaiiy ia aia?ao? Dornier A.I.-4800
(I?ia//eia) c ?a?no?aoe??th e?iaiia?ao ca iaoiaeeeith L.Hatle ?
B.Angelsen (1982). Iniaeeaa oaaaa caa?oaeany ia ii?oi-ooieoe?iiaeuei?
iniaeeaino? eeaiaiiiai aia?aoo na?oey. Io?eiai? aeai? caiineeeny aei
niaoe?aeueii? ea?oe.

Ca iaoiaeii eieoaaiiy ani oai?i aoee ?iciiaeieaii ia /ioe?e a?oie:

I a?oia – 32 oai?eo ia AIN, yeei i?iaiaeeany eo?n iaaaaeic anei?aiiiai?
eeneioe: I oeaeaeaiue – ii 300 ia aioo??oiueii’ycaai, uiaeiy; II ?
III oeaei? – ii 500 ia aioo??oiueii’ycaai, /a?ac aeaiue; IY oeaeaeaiue –
ii 500 ia aioo??oiueii’ycaai, aeaa ?ace ia oeaeaeaiue.

II a?oia – 35 oai?eo ia AIN, yeei aei anei?aiiiai? eeneioe aeiaeaaaany
eo?n ?oiaeiio ii caaaeueiii?eeiyoie iaoiaeeoei: I aeaiue – 0,3 ie;
II aeaiue – 0,5 ie, iio?i ii 1,0 ie aioo??oiueii’ycaai, /a?ac aeaiue,
ia eo?n – 25 ?i’?eoe?e.

III a?oia — 20 oai?eo c ia?aaaaith aa?oaa?aeai/ieo i?iya AIN, yeei
aei aoiiiaoiaaiaoe/iiai eiiieaeno “anei?aiiiaa eeneioa+?oiaeii”
aeiaeaaaany eiiieaen eieoaaeueii? oiceoeueoo?e.

IY a?oia — 32 oai?eo c ia?aaaaith na?oeaai-noaeeiieo i?iya AIN, yeei
aei aoiiiaoiaaiaoe/iiai eiiieaeno “anei?aiiiaa eeneioa+?oiaeii”
aeiaeaaaany eo?n iaaiioioa?aii?. I?ioeaaeo?e i?iaiaeeeeny ca ianooiiith
iaoiaeeeith: ci?iia iaai?oia iiea ia naaiaioa?io ciio na?oey (N5 — Ae5)
c /anoioith iiaoi?aiiy 50 Aoe ? ?iaeoeoeai?noth 35 iOe. I?ioeaaeo?e
i?iaiaeeeeny ia a?o/eciyiiio aia?ao? “IAeIO-01”, ia eo?n 20 uiaeaiieo
i?ioeaaeo? c ?aciaith aeniiceoe??th a 20 oaeeei.

Oni a?oie aoee aiaeiiaiaeii ii aieo i noaoi. Aeineiaeaeaiiy eeiii/ieo,
eaai?aoi?ieo i iino?oiaioaeueieo iieacieeia i?iaiaeeeiny aei i iiney
eo?no eieoaaiiy.

?acoeueoaoe aeineiaeaeaiue ia?iaeaii ca aeiiiiiaith
iaoaiaoe/ii-noaoenoe/ieo iaoiaeia, ?icieoey iieacieeia aaaaeaeany
noaoenoe/ii aeinoia??iith o ?aci p<0,05 ca e?eoa?i?i No’thaeaioa, oaeiae aeei?enoai? noaiaea?oi? caniae ei?aeyoe?eiiai aiae?co. ?acoeueoaoe aeine?aeaeaiiy Oaeoe/iee iaoa?iae ?iaioe neeaaea?oueny c 8 ?icaeieia (II-IO). O II ?icaeiei aeeeaaeathoueny aeuaiaaaaeaii iaoiaee ianoaaeaiiy i eieoaaiiy oai?eo, a oaeiae aeaniee niinia aeiaaiinoeee aiia??ooeeainoi noaeiaia. O III ?icae?e? aeena?oaoe?? i?aaenoaaeai? ?acoeueoaoe aea/aiiy ?iciianthaeaeaiino? AIN. Aeine?aeaeaiiy uiaei ieoaiue ai?aeai?ieia?? AIN a iiioeyoe?? iaeeie/i? (I.Iiae?aoee,1989), a a iao?e e?a?i? ia i?iaiaeeeeny acaaae?. Ianoaaeaiiy ia ?iciianthaeaeai?noue AIN a i?aaeaiiiio ?aa?ii? Oe?a?ie i?iaiaeeeiny na?aae 1060 in?a, a?eueo?noue c yeeo nooaeaioe iaaee/iiai oi?aa?neoaoo i.Iaeane, aeii?eceaieee oa iieiae? ?ia?oieee ?in?enueei? aai oe?a?inueei? iaoe?iiaeueiino?, na?aaei?e a?e 21,0 + 0,6 ?ie?a, ae?iie - 530 in?a, /ieia?e?a - 530 in?a. A oaae.1 a?aeia?aaeai? ?acoeueoaoe io?eiaieo aeine?aeaeaiue. Oaaeeoey 1 ?iciiae?e ianoaaeaieo ii ?ooeeaino? noaeia?a na?aae ianaeaiiy i?aaeaiiiai ?aa?iio Oe?a?ie ( n =1060). ?ooeea?noue noaeia?a*enei in?a c ??ciith ?ooeea?noth noaeia?a %1. O?c?ieia?/ia ?ooeea?noue noaeia?a90285,092. A?ia??ooeea?noue eaaeiai nooiaith12611,893.A?ia??ooeea?noue ae?aaeaiiai nooiaith323,02Onueiai:1060100,0C ieo AIN181,70 ?c oaaeeoe? aeaeii, ui ?iciianthaeaeai?noue AIN a iiioeyoe?? neeaaea? 1,7%. O?aaa caoaaaeeoe, ui na?aae in?a, o yeeo aiia?iiaieueiinoue o?aeooaaeanue oieueee ye iciaea (126 inia c eaaeei nooiaiai i 32 – c ae?aaeaiei), AIN cono?i/aany cia/ii /anoioa – o 11,39% (18 c 158). Aoaeue-yeeo noaoenoe/ii aaaiieo ?ic??ciaiue c ?iciianthaeaeaiino? AIN o in?a ??cii? noao? ie a iaoiio ?i?aeai?ieia?/iiio aeine?aeaeaii? ia ciaeoee. O IV ?icae?e? aeena?oaoe?? iaaaaeai? niaaeeia? aniaeoe AIN: ?acoeueoaoe ee?i?ei-aaiaieia?/ieo aeine?aeaeaiue oa iiooe aaiaoe/iiai ia?ea?o (HLA- ? DR-oeioaaiiy). O a?oi? oai?eo ia AIN c 52 in?a (i?iaaiaee) aoei ianoaaeaii 111 ?iaee/?a I nooiaiy nii??aeiaiino? ( aaoueee, ae?oe, n?ane). AIN aoa aeyaeaiee o 70,27% ?iaee/?a (78 in?a)., ?iciianthaeaeai?noue oa ae?aaeai?noue yeiai iaaaaeai? ia ?en.1. Caaaeueia e?euee?noue ?iaee/?a (111 in?a) 100% ii?ia ? aeia?iye?nia AIN a?ia?iia?euei?noue (78 in?a – 70,27%) (33 iniae — 29,73%) eaaeee nooi?iue ae?aaeaiee nooi?iue iioe?aia eieae?ciaaia (42in.-53,84%) (36in.-46,15%) (74in.-94,87%) (4in.-5,13%) ?en.1 ?iciiae?e ?iaee/?a I nooiaiy nii??aeiaiino? uiaei aiia??ooeeaino? noaeia?a, ?? ae?aaeaiino? ? ?iciianthaeaeaiino?. Aeaeii, ui o 29,73% ?iaee/?a ianoaaeaieo oai?eo a?ia??ooeea?noue ia cono??/aeanue acaaaei aai iineea aeia?iye?niee oa?aeoa?, yea a?aeianaia iaie ia ?aooiie ii?ie (29,73%). Aea o?aaa caoaaaeeoe, ui caaaeueiee aiaenioie oaeeo ?iaee/ia aoa o 2,4 ?ace iaioei (29,73%) iiae aiaenioie ?iaee/ia, oai?eo ia AIN. Iaeaea iaeiaeiai /anoi a?aecia/aeany eaaea oa ae?aaeaia eiai oi?ia, a uiaei ?iciianthaeaeaiino? cia/ii ia?aaaaeaea iioe?aia oi?ia (94,87%). Ie??i oiai, aeine?aeaeoaaany oaeiae eiao?oe??io niaoeeo?/iiai aioo??oiuein?iaeiiai iaeiie/aiiy (?iaeaen Penrose) ? eiai caeaaei?noue a?ae nooiaiy a?ia?iia?eueiino?. Anoaiiaeaii, ui o ?iaee/?a I nooiaiy nii??aeiaiino? a?ia??ooeea?noue noaeia?a niinoa??aa?oueny o 2,25 ?ac?a /ano?oa, i?ae o iiioeyoe??. A?aeiii, ui ?iaeaen Penrose a??ia?aeiee, yeui eiai aaee/eia ia ? iaioith ca 2,0. Aeine?aeaeaiiyie oaeiae anoaiiaeaii, ui /ei aeuee nooi?iue a?ia?iia?eueiino? ? eiai iioe?aiino?, oei a?eueoa eiia??i?noue eiai ia?aaea/? a?ae iaeiiai aai aeaio “a?ia?iia?eueieo” aaouee?a. A?aoiaoth/e ?ica?aei?noue iiaeyae?a ??cieo aaoi??a ia oa?aeoa? niaaeeiaino? AIN (P.Beighton o ni?aaao.,1983; A.Child,1986; I.Iiae?aoee,1989), ie ca aeiiiiiaith niaoe?aeueii ?ic?iaeaieo aeey oe??? iaoe oaaeeoeue( A.I.Ne?ioeei o ni?aaao.,1973) aea/aee oei niaaeeiaino? iciaee oa ?? iaiao?aioi?noue. I?iaaaeaieie ?ic?aooieaie onoaiiaeaii, ui a?ia??ooeea?noue noaeia?a oniaaeeiao?oueny ca aooiniiii-aeii?iaioiei oeiii c aeineoue aenieei ??aiai iaiao?aioiino? aaiioeio (0,7–0,8) ? ? aeineoue neeueiei oaeoi?ii, ui i?iaieo? oi?ioaaiiy AIN ye naiino?eii? iicieia?/ii? oi?ie. Ie??i oiai, i?eeiath/e aei oaaae inoaii? iia?aeiieaiiy aaoi??a uiaei ci?i c aieo eeaiaiiiai aia?aoo oai?eo ia AIN (A.H.Child,1986 oa ?i.), iaie aoei i?iaaaeaii aoiea?ae?ineii?/ia ianoaaeaiiy i?iaaiae?a ? ?iaee/?a, ?acoeueoaoe yeiai na?ae/eee, ui cia/ii a?eueoa ii?aeio?oueny i?ieain i?o?aeueiiai eeaiaio c AIN o i?iaaiae?a (57,7%) ? o ?iaee/?a I nooiaiy nii??aeiaiino? (37,1%) o ii??aiyii? c iiioeyoe?eiith ?iciianthaeaeai?noth IIE (2,6–5,0%). Aiaeia?/i? ?acoeueoaoe io?eiai? a?aeiinii o?eeoni?aeaeueiiai eeaiaio oa ii?aeiaiiai o?aaeaiiy iaio eeaiai?a. Iaiao?aeii oaeiae cacia/eoe, ui i?eaeecii iieiaeia ianoaaeaieo ?iaee/?a (53,85%) iaea iciaee aeen?aaoeyoe?? aaaaoaoeaii? ia?aiai? nenoaie, ye? aeineoue /anoi ?a?no?oaaeeny iaie o i?iaaiae?a (84,6%). Aea/ath/e ieoaiiy niaaeeiaino? AIN, ie cae?enieee iiooe aaiaoe/iiai ia?ea?o noeeueiino? aei ?icaeoeo oeueiai caoai?thaaiiy. C oe??th iaoith iaie i?iaaaeaii aea/aiiy nenoaie oeaieiii? a?noinoi?niino? oai?eo ia AIN ca ?acoeueoaoaie HLA- ? DR-oeioaaiiy. Aeine?aeaeaiith i?aeeyaaee eieone A, B, C, D ? DR. A ?acoeueoao? ianoaaeaiiy 34 oai?eo (ii??aiyiiy i?iaiaeeeiny c iiioeyoe?eieie aeine?aeaeaiiyie aiaeia?/ieo ?an c iaoa??ae?a 8-ai Oi?eoiia - 267 in?a) anoaiiaeaii, ui iaea?eueo /anoi o oai?eo ia AIN cono??/aeeny aioeaaie A8, A35 ? DR1 (e?eoa??e “a?aeiiniiai ?eceeo” R>2) (oaae.2).

Oaaeeoey 2

*anoioa aeyaeaiiy aioeaai?a a?noinoi?niino? o oai?eo ia AIN ? caei?iaeo
in?a.

Aioeaaie Eiio?ieue((%) (n=267)Oai?? ia AIN (%) (n =
34)RA123,2235,091,78A249,0635,29A324,3414,71A1111,2414,71A720,2211,76A81
2,7335,00*3,67A1511,618,82A178,248,82A3520,6035,00*2,075DR117,334,12*3,9
2DR225,0020,59DR321,7435,291,93

O V ?icae?e? aeena?oaoe?? iaaaaeai? ?acoeueoaoe aea/aiiy iaoiaaiaco AIN
o na?o? a?io?i?/ieo ci?i o oeeo oai?eo. ?aeeii? oi/ee ci?o ia
iaoiaaiaoe/i? iaoai?cie ?icaeoeo AIN iaia?, a?aeiii o?eueee, ui ioneiaei
iaoai?ciii yaey?oueny ii?ooaiiy neioaco ? ?iciaaeo eieaaaio.

Aa?o/e aei oaaae oa, ui a iniia? ii?iaeueii? aeeoo?ae?yeueiino?
niieo/ii? oeaieie iieyaa? aeeiai?/ia ??aiiaaaa i?ae
a?ineioacii aeno?aoeaethey?ieo eiiiiiaio?a ( cie?aia aieieienoeo niieoe
) oa aacia?a?aiei eaoaaie?ciii oeeo eiiiiiaio?a, aeyaeeiny oe?eaaei
aea/aiiy ni?aa?aeiioaiiy i?ae iniiaieie aea?eaaoaie eieaaaio
(ienei?ie?i), niaoeeo?/ieie niieo/iioeaieiieie oa?iaioaie (eieaaaiaca,
aeanoaca) oa ?o ?ia?a?oi?aie a ne?iaaooe? e?ia? oai?eo ia AIN.

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui o oai?eo
a?aecia/aeenue ci?ie iieaciee?a ienei?ie?io, i?ioaie?oe/ii? oa
?ia?a?oi?ii? aeoeaiino? e?ia?, ye? iiaeooue iieyaaoe a iniia?
iaoaaie?/ieo ii?ooaiue niieo/ii? oeaieie, ui oaeiae i?aeoaa?aeaeoaaeinue
ciaioaiiyi caaaeueiiai a?eea e?ia? oai?eo ia AIN (oaae.3).

Oaaeeoey 3

Iieacieee ienei?ie?io, i?ioaie?oe/ii? oa ?ia?a?oi?ii?

aeoeai?no? e?ia? o oai?eo ia AIN.

Iaeiaioaaiiy iieacieea

Eiio?ieue (n=30)?acoeueoaoeoe aeine?aeaeaiiy o oai?eo ia AIN (
n=47)

?Ienei?ie?i (iea/ie)1,50+0,101,70+ 0,03?>0,05Eieaaaiaca
(iiieue/n/ie)8,05+0,3610,6+0,1?<0,05Aeanoaca (iiieue/n/ie)6,35+0,7814,07+0,10?<0,05Iaeo?aeueia i?ioaaca (iiieue/n/ie)2,05+0,126,71+0,76?<0,05Eaoainei Ae (iiieue/n/ie)8,65+0,7510,78+0,75?<0,05Aieie (a/e)66,51+1,7362,68+1,60?>0,05?ia?a?oi?ia
aeoeai?noue(ia/ie)1,69+0,131,79+0,08?>0,05

C oaaeeoei aeaeii, ui o oai?eo ia AIN a?eueo?noue iieaciee?a iineei
iaeiini?yiiaaiee oa?aeoa? – aeinoia??ii i?aeaeuoaaeanue aeoeai?noue
oa?iaio?a, ciaiooaaeanue e?euee?noue a?eea ? ca?eueooaaeanue e?euee?noue
aea?eaao?a eieaaaio. Ona ?acii oea na?ae/eei i?i ?iciaae ? aeeno?io?/i?
ci?ie a?eeiaeo eiiiiiaio?a niieo/ii? oeaieie ia oii? i?aeaeuaiiy
“aa?aneaii?” ae?? oa?iaio?a ia aieieieno? niieoee, a naia ia eieaaai ?
aeanoei.

Io?eiai? aeai? naiae/eee i?i ii?ooaiiy eeneioii-eoaeii? ??aiiaaae
ia?aaaaeii a a?e aoeeaeico o oai?eo ia AIN. Aeey ia?aa??ee aeaii?
a?iioace ianooiiei aoaiii iaoi? ?iaioe aoei aea/aiiy eeneioii-eoaeiiai
aiiainoaco o aeaii? eaoaai??? oai?eo.

A?aeiii, ui ie??i o?ueio aieiaieo nenoai, ui i?aeo?eiothoue
eeneioii-eoaeiee aiiainoac a i?aai?ci? ethaeeie oa oaa?eie
(?ani??aoi?ii?, aene?aoi?ii?, aooa?ii?) a inoaii? ?iee aeyaeaii
?nioaaiiy ua e /aoaa?oi? nenoaie – iaoaaie?/ii?
(Ae.A.Iaeueie/oe,1983;1989). Oiciieiai/ia nooue oei?? nenoaie iieyaa? o
?aaoethaaiii iioaineaiinoi aca?iiia?aoai?aiue iioeieo i?aaii/ieo eeneio
i iniiaaiie o aieueo neaaei /e a iaeo?aeuei? niieoee i iaaiaee.

Aea/ath/e ni?aa?aeiioaiiy ieeneaieo iaoaaie?o?a ae?eie?co (i??oaao,
ienaeiaoeaoao) aei a?aeiiaeaieo (eaeoao, iaeao) a ieaci? e?ia? oai?eo ia
AIN, iaie niinoa??aaeinue ca?eueoaiiy oeeo iieaciee?a, ui na?ae/eoue
i?i ni?yiiaai?noue ?aaoeyoe?? ia i?aeo?eieo iaoai?cio ooai?aiiy
i?aai?/ieo eeneio i?ae /an yaeu iaoaaie?/iiai aeeaeico: I??/eae – 1,63
i?e 0,16 o eiio?ie?, I??/iae – 0,86 i?e 0,63 o eiio?ie?, Ia/iae – 1,86
i?e 0,09 o eiio?ie?. Aeiaaio?eaaea i?io?eaiiy eiiiainaoi?ieo ?aaeoe?e
i?ae /an aeeaeico ciaioo? aieiaii noano?aoe oeeo ?aaeoe?e – ae?eiaai oa
?ioi iie?naoa?eaeii noano?aoe, aeeth/ath/e aeieiciaiiiiaeieaie niieo/ii?
oeaieie. Oea noi?iaiaeaeo?oueny ciaioaiiyi ai?noo i?aai?/ieo eeneio, ui
anoaiiaeaii iaie ?o aeinoia??ieie ci?iaie a ieaci? e?ia? oai?eo ia
AIN.

Aeuaaeacai? ci?ie ni?e/eiythoue ?icaeoie ?aaeoe?e aoi?eiiiai
iaoaaie?/iiai aoeeaeico, i?i ui na?ae/aoue iaea?aeai? iaie aeai?
cieaeaiiy aeoeaiino? IAAe-caeaaeii? iaeaoaeaa?ae?iaaiace (0,102+0,007
iiieue/n/ie i?e 0,340+0,013 iiieue/n/ie o eiio?iei, p<0,05), oa ca?eueoaiiy aeoeaiino? o?oeoiciaeeoinoioace (0,106+0,007 iiieue/n/ie i?e 0,052+0,012 iiieue/n/ie o eiio?ie?, ?<0,05). Iayaiinoue eiiiainaoi?iiai aoeeaeico o oai?eo ia AIN iiaeoaa?aeaeo? oaeiae caieueoaiiy niiaaiaeiioaiiy oiieia aei aeenoeueoiaeia (0,90 i?e 0,48 o eiio?iei). Io?eiai? ?acoeueoaoe na?ae/aoue, ui aeeno?io?/i? ci?ie, iia`ycai? c i?aeaeuaiiyi ?iciaaeo oa ooee?caoe??th iie?naoa?eaeieo niieoe niieo/ii? oeaieie i?ae /an aeeaeico (ioeiiie?naoa?eaee), o aeiaaeeo aoi?eiiiai aoeeaeico aeiiiaiththoueny ?iciaaeii oa aeeno?io?/ieie ci?iaie a?eeiaeo eiiiiiaio?a oe??? oeaieie (eieaaai, aeanoei). Oaeei /eiii, aeey oai?eo ia AIN oa?aeoa?ia ii?ooaiiy eeneioii-eoaeii? ??aiiaaae ?c ci?uaiiyi a noi?iio iaoaaie?/iiai aeeaeico oa ia?aaaaeath/ith eiiiainaoe??th oeueiai noaio oeyoii ?icaeoeo aoi?eiiiai iaoaaie?/iiai aoeeaeico, ui i?ecaiaeeoue aei a?eeiai? iaaeinoaoiino? niieo/ii? oeaieie c aeoiaeii a a?ia?iia?euei?noue. Iaaeinoaoiinoue niieo/ii? oeaieie iaoiiaeaia ia oieueee ao?aoith aieea eieaaaiiaeo ? aeanoeiiaeo aieieii, aea ? ao?aoith aoaeaaiae?a ioeiiie?naoa?eaeiiai eiiieaeno i?ii?aeii? ?a/iaeie. Oaeiae iaiao?aeii caoaaaeeoe ia ua iaeei iaoiaaiaoe/iee iaoaiici ?icaeoeo caoai?thaaiiy – aeey eiiiainaoei? aeeaeico ca?eueoo?oueny aeae?eaiiy ?ii?a I+ oa aeeth/aiiy ?o a i?io?a?eee, ui i?eaiaeeoue aei ?o ?icneaaeaiiy, /ei iiaeia iiynieoe /anoi ci?ie i’ycaaiai ea?eano a oe?eiio ? ia?ea?oeeoey?ii cie?aia o oai?eo ia AIN. O YI ?icae?e? aeena?oaoe?? iaaaaeaii aeieeaaeiee ee?i?ei-ooieoe?iiaeueiee aiae?c iaoieia?/ieo i?iya?a c aieo iii?ii-?ooiaiai aia?aoo, na?oeaai-noaeeiii? nenoaie, a oaeiae ?ioeo i?aai?a ? nenoai oai?eo ia AIN. Aeine?aeaeaiiy ii cai?iiiiiaai?e iaie iaoiaeeoe? aeyaeaiiy ?ooeeaino? noaeia?a aeicaieeei aeineoue /?oei a?ae??ciyoe ii?io ? iaoieia?th, oei a?eueoa, ui a?aeianaiiy i?aeaeuaii? ?ooeeaino? noaeia?a aei a?ia?iia?eueiiai neiae?iio ie cae?enithaaee eeoa i?e iayaiino? o oai?iai ?ioeo iciae o?aaeaiiy iii?ii-?ooiaiai aia?aoo (neie?ic, inoaioiiae?ic, a?o?aea??, ooeiaeaeaiiy ca`ycie oa nooiaeeee?a ? o.i.). Oiio ui AIN ?icaeyaea?oueny iaie ye nenoaiia caoai?thaaiiy niieo/ii? oeaieie, ?aoaeueia ianoaaeaiiy 130 oai?eo aeicaieeei aecia/eoe aea? ee?i?/i? oi?ie AIN: 1) c iaoieia?/ieie iciaeaie ia?aaaaeii c aieo noaeia?a (noaeiaiaa oi?ia); 2) c iaio ae?aaeaieie iaoieia?/ieie iciaeaie c aieo noaeia?a, a a?eueo ae?aaeaieie c aieo ?ioeo i?aai?a ? nenoai (iicanoaeiaiaa oi?ia). Nooi?iue a?ia??ooeeaino? iiaea aooe eaaeith ? ae?aaeaiith, a ii ?iciianthaeaeaiiino? iaie aecia/aeanue eieaeueia ? iioe?aia oi?ia AIN. Noiniaii noaeiaiai? oi?ie AIN ne?ae a?aecia/eoe, ui oae? oai?? iae/ano?oa nea?aeeeeny ia aie? a noaeiaao (/ano?oa aaeeeeo) – 53,06% oa aie? a o?aao? (/ano?oa o a?oaeiiio ? iiia?aeiaiio a?aeae?eao) – 46,94%. A?o?aea?? aoee aeoaea noiae? c oaeeie i?e aeaoi?ioth/iio inoaia?o?ic? – iii??ii? ?ioaineaiino?, iaoaicaeaaei?, i?e o?ce/iiio iaaaioaaeaii? iineeththoueny. Aa?oaa?aea?? aoee iaoiiaeai? iani?iiiaei?noth ca’yceiaiai ? i’yciaiai aia?ao?a i?e AIN, ui ?iaeoue iaa?oue iii??i? iaaaioaaeaiiy iaaei??ieie aeey in?a c oe??th iaoieia??th. Iinooiiai oi?io?oueny o?ii?/iee aieueiaee aa?oaa?iaaiiee neiae?ii c ia’?eoeaiith ee?i?/iith neiioiiaoeeith: ia ii/aoeo aac aeaeeieo ?aiaaiieia?/ieo ci?i, a i?ci?oa – c oeiiaith ?aiaaiieia?/iith ea?oeiith ii oeio inoaioiiae?ico o?aaoa. Iaea?eueo iioe?aieie ?aioaaiieia?/ieie ci?iaie o oeeo oai?eo oaeiae aoee: neie?ic (63,46%), neea?icoaaiiy caieeath/eo ieanoeiie (51,92%), oi?c?y o?e o?aaoe?a (48,08%), ?aii?e inoaioiiae?ic (48,08%), aaeaaeaiiy a caieeath/? ieanoeiee o?e o??aoe?a (21,15%), ii/aoeia? i?iyae e?aeiaeo e?noeiaeo ?ic?inoaiue (21,15%). Iaiao?aeii oaeiae a?aecia/eoe, ui /anoioa aieth o aaeee?o noaeiaao ? o?aao? ca?eueooaaeany i?yii i?iii?oe?eii nooiaith ae?aaeaiino? a?ia?iia?eueiino?. Aiaiianoe/ii aeineoue /anoi o oai?eo ia AIN a?aecia/aeeny /ano? (32,3%) ? cae/i? aeaeoe noaeia?a (11,5%), /ano? ?icoyaiaiiy ca`ycie ? nooiaeeee?a (30,8%), noeeuei?noue aei ia?aeii?a e?noie (5,38%). I?e ia`?eoeaiiio ianoaaeaii? oai?iai aeineoue /anoi caa?oaa ia naaa oaaao “niaoeeo?/iee” habitus, a naia: aenieee c??no, anoai?/ia aoaeiaa o?ea, a?iio?io?y i`yc?a, aeiaa? oa oiie? iaeueoe? ?oe, /anoi ieineinoii?noue (37,7%). Aeey ia’?eoea?caoe?? aio?iiiiao?e/ieo iieaciee?a aeine?aeaeoaaeenue aiie?ooaea ?iciaoo ?oe, ni?aa?aeiioaiiy aa?oiueiai oa ieaeiueiai naaiaio?a o?ea, ?o/ia ? noaiiaa aeeiaiiiao??y. ?acoeueoaoe iieacaee ca?eueoaiiy aiie?ooaee ?iciaoo ?oe o oai?eo ia AIN (162,0+10,8 ni i?ioe 141,3+5,4 ni o eiio?ie?, ?>0,05), ciaioaiiy
ni?aa?aeiioaiiy aa?oiueiai oa ieaeiueiai naaiaio?a o?ea (0,88+
0,03 i?ioe 0,92 +0,01 o eiio?ie?, ?>0,05). Io?eiai? iieacieee ia
yaeythoueny niaoe?o?/ieie aeey AIN, aea ?acii c aenieei c??noii oa
iaaiei aaa?oonii aeicaieythoue cai?aeic?eoe aiiiae?? ?icaeoeo niieo/ii?
oeaieie. A?eueo nooo?a? ci?ie aoee io?eiai? i?e aea/aii? iieaciee?a
?o/ii? ? noaiiai? aeeiaiiiao???, ye? aoee a??ia?aeii ciaioai? o oai?eo
ia AIN ( ?o/ia i?aaa aeeiaiiiao??y — 25,15+2,03 i?e 31,53+2,12 o
eiio?ie?, ?o/ia e?aa aeeiaiiiao??y – 23,12+2,15 i?e 30,18+2,55 o
eiio?ie?, noaiiaa aeeiaiiiao??y – 44,72+4,45 i?e 60,04+5,96 o
eiio?ie?).

Aeoiaey/e c nooiino? caoai?thaaiiy, iicanoaeiaia? i?iyae AIN iiaeii?
aooe ??ciiiai?oieie. Iaea?eueo /anoi a?aecia/aeeny ci?ie c aieo
na?oeaai-noaeeiii? nenoaie. Ia?aaaaeaee ianooii? nea?ae: a?eue a
ae?eyioe? na?oey, yea aeieeaea a?ae o?ce/iiai oa aiioe?iiaeueiiai
iaaaioaaeaiiy, ii?ooaiiy na?oeaai? ae?yeueiino?, ci?ie ??aiy
a?oa??aeueiiai e?ia`yiiai oeneo. 27,69% oai?eo nea?a c aieo
na?oeaai-noaeeiii? nenoaie ia iaee.

Ea?ae?aea?? (48,46%) iineee /ano?oa eieth/ee oa?aeoa? ? iaaecae/aeii
??aeei — noeneoth/ee aai aeaaey/ee. Iaioa /anoeia oai?eo a?aecia/aea
ca’ycie aieth c o?ce/iei iaaaioaaeaiiyi (35,93%), a oie /an ye
caeaaei?noue a?ae aiioe?eiiai iai?oaeaiiy a?aecia/aea ia?aaaaeia
e?euee?noue oai?eo (90,62%). Aie? aoee ei?ioei/ani?, aac ??aae?aoe?? ?,
ye i?aaeei, i?ioiaeeee naiino?eii aai i?ney ei?aaeieo, aaeiea?aeeio ?
naaeaoeaieo i?aia?ao?a.

Nea?ae ia ii?ooaiiy na?oeaai? ae?yeueiino? iaee aeecueei iieiaeie oai?eo
(41,54%). C ieo a?eueo iieiaeie nea?aeeeeny ia iaiioeaiaai?, aai ae
ni?iaieiaai? aiioe?iiaeueiei iai?oaeaiiyi i?enooie oao?ea?ae??, ye?
i?ioiaeeee /ano?oa naiino?eii. 37,5% oai?eo a?aecia/aee ii?ooaiiy ?eoio
na?oeaai? ae?yeueiino?, iae/ano?oa o aeaeyae? aeno?anenoie?/ii? a?eoi??.
O?eueee o 2 oai?eo (9,5%) niinoa??aaeany ii?iinenoie?/ia oi?ia
ieaioeeai? a?eoi??.

Nea?ae ia eaa?euei?noue a?oa??aeueiiai oeneo oaeiae niinoa??aaeeny
o cia/ii? e?eueeino? oai?eo (43,85%). Noeeuei?noue aei
a?iioii?? aoea ca?a?no?iaaia o 40 c 57 oai?eo (70,17%), aei a?ia?oii?? —
eeoa o 17 (29,82%). Oea noi?iaiaeaeoaaeinue ianooiieie nea?aaie:
aieiaie?oae?iiy, aaeeiai?y, oaeaeea aoiiethaai?noue, ?iiae? iai?eoiii?
noaie.

A?aoiaoth/e oa, ui aeuaaeeeaaeaiee neiioiiieiiieaen nea?a iaaaaeo?
oaeee i?e iae?i-aoii?aeueiiio aeenaaeain? na?oeaai-noaeeiii? nenoaie,
iaie aoei i?iaaaeaii ianoaaeaiiy oai?eo ia AIN c iaoith aeyaeaiiy nea?a,
oa?aeoa?ieo aeey aaaaoi-noaeeiii? aeenoii??. Iae/ano?oa oai??
nea?aeeeeny ia neaae?noue, oaeaeeo noiieai?noue, a?ae/oooy iaaeinoa/?
iia?o?y, ianoa?ii?noue niaee oa aeooioe, iacaaeiaieai?noue aaeeoo,
oaeaeea caea/oaaiiy o o?ainii?o?, aieiaie?oae?iiy, ??aeoa — aieiaiee
a?eue, neieiiaeuei? noaie.

Oaeei /eiii, o ia?aaaaeii? a?eueoino? oai?eo (80,76%) anoaiiaeaia
aaaaoi-noaeeiia aeenoii?y, yea aeyaeyeany cia/ii /ano?oa c ia?aaaaith
neiiao?eioii?? (80,95%), i?ae aaaioii?? (19,5%). ?icaeyioaoe ie?aii
a?oio i?iaaiae?a ? a?oio ?iaee/?a I nooiaiy nii??aeiaiino?, ie aecia/eee
iaeiie/aiiy aaaaoi-noaeeiii? aeenoii?? ye iciaee ? cieaeaiiy ?? iaeaea
iaiieiaeio (53,85%) o ianoaaeaieo ?iaee/?a, ui i?aeoaa?aeaeo? ??
niaaeeiao ia?aaea/o a?ae iaeiiai c aaouee?a. Oea i?aeoaa?aeaeo? aeoieo
?.A.Ai?aeiia o ni?aaao. (1984), aenoioaoei a?iioaco i?i aaiaoe/io
iaoiiaeai?noue o??aaee neiioii?a: i?ieain i?o?aeueiiai eeaiaio,
aaaaoi-noaeeiia aeenoii?y ? niieo/iioeaieiia aeenieac?y. C iiceoe??
ii?aeiaiiai oniaaeeoaaiiy AIN ? ANAe iiynith?oueny oaeiae ianooiiee
oaiiiai, yeee /anoi con??/a?oueny o oai?eo ia AIN – i?ieain i?o?aeueiiai
eeaiaio.

Aoiea?ae?ia?ao?/ia aeine?aeaeaiiy na?oey aoei i?iaaaeaii o 130 oai?eo
ia AIN. Iaea?eueo /anoi (52,31%) o oai?eo cono??/aany i?ieain
i?o?aeueiiai eeaiaio, ??aeoa — i?ieain o?eeoni?aeaeueiiai eeaiaio
(11,54%), i?ieaine iaio eeaiai?a iaeii/anii o 15,38% oai?eo. Aeineoue
/anoi a?aecia/aany aeaoaeo i?aeoeoii/eiai? ia?aoeiee (14,61%), aeaoaeo
i?aeia?aaena?aeii? ia?aoeiee (9,23%), iayai?noue aeiiii?aeii? oi?aee
a?aecia/aeanue o 38,46% aeiaaee?a ? a 37,69% — ?icoe?aiiy aeno?aeiiai
a?aeae?eo aeoae ai?oe.

Iaea?eueo /anoei ? aeinoaoiuei “a??ciei” oneeaaeiaiiyi i?ieaino
i?o?aeueiiai eeaiaio ? a?eoi?y. *ano?oa oea aoea neioniaa oao?ea?ae?y
(55,56%), iio?i oeoii/eiaa aeno?anenoie?y (27,78%), cia/ii ??aeoa —
ieaioeeaa a?eoi?y (5,56%), a?aae?a?eoi?? oa ii?ooaiiy
ao??iaaio?eeoey?ii? i?ia?aeiino? (11,11%).

I?e ia`?eoeaiiio ianoaaeaii? oai?eo ia AIN c aieo na?oeaai-noaeeiii?
nenoaie caa?oaee ia naaa oaaao iayai?noue a?eoi?e, eaa?euei?noue
a?oa??aeueiiai oeneo, iai?eoiii? oa ia?aaeiai?eoiii? noaie, cieaeaia
oiea?aioi?noue aei o?ce/iiai iaaaioaaeaiiy, a oaeiae iciaee
aaaaoi-noaeeiii? aeenoii??. I?e aoneoeueoaoe?? /ano?oa caa?oaee ia naaa
oaaao i?eaeooai? na?oeaa? oiie, nenoie?/iee ooi ia aa?o?aoe? na?oey.

O?aaa caoaaaeeoe, ui on? ia?ae?/ai? iciaee ia ? niaoeeo?/ieie aeey
oai?eo ia AIN ? o?eueee o noeoiiino? ?c nea?aaie oa iciaeaie o?aaeaiiy
iii?ii-?ooiaiai aia?aoo iiaeia cai?aeic?eoe iayai?noue o oai?iai
nenoaiii? niieo/iioeaieiii? aeenieac??.

Aeaeo?iea?ae?ieia?/i? iciaee ianoaaeaii? a?oie oai?eo oaeiae aoee
ianiaoeeo?/i?: /ano?oa aa?oeeaeueia iiceoe?y na?oey, iii??ia cieaeaiiy
naaiaioa ST o I, II oa a e?aeo a?oaeieo a?aeaaaeaiiyo, iaeaea caaaeaee
iaaaoeaiee coaaoeue O o III a?aeaaaeaii? i?e i?ieain? caaeiuei? nooeee
ieo?aeueiiai eeaiaio, iaoieia?/iee coaaoeue U. A?eueoa /anoeia AEA-ci?i
a?aecia/aeanue o oai?eo c i?ieainaie eeaiai?a, ui ni?aiaaea? c aeaiieie
?ioeo aaoi??a.

Iie?ii?o?ci aeyaeaieo neiioii?a oa iciae i?e ianoaaeaii?
iii?ii-?ooiaiai aia?aoo ? na?oeaai-noaeeiii? nenoaie eeoa i?aee?aneth?
nenoaiia o?aaeaiiy niieo/ii? oeaieie.

C aieo ?ioeo nenoai i?aai?cio oaeiae a?aecia/aeeny iaoieia?/i? ci?ie.
Oae, iaea?eueoa e?euee?noue ii?ooaiue aoea aecia/aia i?e ianoaaeaii?
ia?aiai? nenoaie. I?e oeueiio a?eueoa /anoeia nea?a aoea i?iyaeaiiyi
aaaaoi-noaeeiii? aeenoii??. Ie??i oiai, cono??/aeeny i?a?ai? (32,31%),
iai?eoiii? noaie (13,77%), ii?ooaiiy iiceiaiai e?iaiia?ao (9,16%),
ai?eain?y (4,62%).

Cia/ii iaioa e?euee?noue nea?a aoea o oai?eo c aieo aeeoaeueii? nenoaie.
O 13,89% oai?eo aoa ae?aaiinoiaaiee o?ii?/iee a?iio?o, o 21,58% —
aio?caia eaaaiue. O aeayeeo oai?eo a?aecia/aeeny aea?a?/i? ?aaeoe??
(ianoa?ii?noue aei ??cieo caiao?a, i?aeaeuaii? aieiaino?, oiiieeiiai
iooo ? o.i.). Aea?a?/i? ?aaeoe?? a?aecia/aeeny o oai?eo ? c aieo o?aaii?
nenoaie (ianoa?ii?noue iaaieo i?iaeoeo?a — aa?aieia, aee?ia i`yni oa
?i.) O 9,52% oai?eo i?e oeueo?acaoeiaiio aeine?aeaeaii? anoaiiaeai?
??ciiiai?oi? aeaoi?iaoe?? aeia/iiai i?oo?a (S-iiae?aiee caei oeeee,
caeae o?ea), a?ia?- oa a?iiiioi?ia aeene?iac?y.

C aieo na/iaeae?eueii? nenoaie caa?oaee ia naaa oaaao iaoia? a?eae? o
/ieia?e?a (8,46%), noeeuei?noue aei i?ioa?io??? (13,89%), iao?iioic
(3,09%). O ae?iie a?aecia/aeenue iiouaiiy iaoee oa i?oae (11,1%), cae/i?
aeeeaeeo? (5,55%).

Eiinoeueoaioii-ieoe?noii aeineoue /anoi a?aecia/aeeny ci?ie c aieo
i?aaia ci?o: i?ii?y o 27,27 % oai?eo, a?ia?iao?ii?y o 4,55% oai?eo,
??ciee nooi?iue i?aeaeaeoo o?onoaeeea o 6,82% oai?eo, aia?iiao?y
n?o/aoee oaeiae o 6,82% oai?eo.

O YII ?icae?e? aeena?oaoe?? aiae?cothoueny ?acoeueoaoe uiaei aea/aiiy
ee?i?/ieo, eaai?aoi?ieo ? ?ino?oiaioaeueii aeyaeaieo iniaeeainoae
aeaiiai caoai?thaaiiy, a oaeiae ?ic?iaea oa nenoaiaoecaoe?y e?eoa???a
ae?aaiinoeee AIN, ye? i?iiiiothoueny aeey aaeeaaiiy a oe?ie?e iaaee/i?e
i?aeoeoe?.

Ee?i?/i? i?iyae aeey c?o/iino? iiae?eai? ia “aaeee?” ? “iae?”.

Aei “aaeeeeo e?eoa???a” iaeaaeaoue:

1) a?ia?iia?euei?noue iaeiiai aai aeae?eueeio noaeia?a;

2) iaoieia?y c aieo iii?ii-?ooeeaiai aia?aoo;

3) iayai?noue aaaaoi-noaeeiii? aeenooieoe??;

4) i?ieain i?o?aeueiiai eeaiaio;

Aei “ iaeeo e?eoa???a” iaeaaeaoue:

1) a?o?aea??, aa?oaa?aea??, “iaoyaeoth/ee” ii iii?ii-?ooiaiio
aia?aoo aiaiiac (neie?ic, inoaia?o?ic, inoaioiiae?ic, ia?nenooth/ee
neiia?o, caeeea ?icoyaiaiiy ca’ycie, noeeuei?noue aei aeaeo?a ? o.ae.);

2) ea?ae?aea??, a?eoi??, eaa?euei?noue a?oa??aeueiiai oeneo;

3) iayai?noue ii?ooaiue eeaiaiiai aia?aoo oa ?ioeo no?oeoo? na?oey
(iaeaaaeeea?oa cia/aiiy iathoue i?ieaine oa ?icoe?aiiy aeoae ai?oe);

4) iicanoaeiaia? i?iyae c aieo ?ioeo i?aai?a oa nenoai (i?aai ci?o,
ia?aiaa, aeeoaeueia, o?aaia, na/inoaoaaa nenoaie);

Ae?aaiic AIN a?oioo?oueny ia aeyaeaii? on?o aai aeayeeo ?c
aeuaaecia/aieo e?eoa???a, i?e/iio ia?o? aeaa c “aaeeeeo”
(a?ia?iia?euei?noue noaeia?a + iaoieia?y iii?ii-?ooiaiai aia?aoo)
aaaaeathoueny iaia`yceiaeie aeey AIN.

Iaiao?aeii a?aoiaoaaoe, ui ?iiae? ae?oaee c “aaeeeeo” e?eoa???a
(noaeiaia? aai aa?oaa?iaaii? i?iyae caoai?thaaiiy) aoaa? ee?i?/ii
ae?aaeaiee cia/ii iaioa, i?ae aoaeue-yeee c “iaeeo”. On? e?eoa???, ie??i
a?ia?iia?eueiino?, ia iathoue niaoeeo?/iino? uiaei aeaiiai
caoai?thaaiiy, iaeiae, on? c ieo a a?eueoiio (“aaeee? e?eoa???”), aai a
iaioiio (“iae? e?eoa???”) nooiai? anioe?eiaai? c iei. O ?icae?e? YII
?aoaeueii i?iaiae?ciaai? on? ?c cai?iiiiiaaieo ee?i?/ieo e?eoa???a.

Ie??i oiai, cia/io aeiiiiiao a ae?aaiinoeoe? caoai?thaaiiy a?ae?a?athoue
ianooii? eaai?aoi?i? oanoe:

1. Aecia/aiiy eeneioii-eoaeiiai aaeaino — ci?uaiiy a a?e iaoaaie?/iiai
aeeaeico c oi?ioaaiiyi aoi?eiiiai iaoaaie?/iiai aoeeaeico.

2.Aecia/aiiy aea?eaao?a eieaaaio ? oa?iaioii-?ia?a?oi?ii? nenoaie
niieo/ii? oeaieie — ca?eueoo?oueny ??aaiue ienei?ie?io e?ia? oa
aeoeai?noue oa?iaio?a, eiiiainaoi?ii aeaui ca?eueoo?oueny nooi?iue
?ia?a?oi?ii? aeoeaiino?.

3.HLA- ? DR-oeioaaiiy — iaea?eueoee anioe?aoeaiee ca`ycie c aioeaaiaie
A8, A35 ? DR1.

Cia/io ?ieue o ae?aaiinoeoe? AIN oa o?aeoiaoe? eiai iniiaieo ee?i?/ieo
i?iya?a a?a? aaiaaeia?/iee aiaiiac, aea/aiee o yeiiiaa a?eueoi?
e?eueeino? iieie?iue (iayai?noue AIN aai a?ia?iia?eueiino?, o?aaeaiiy
iii?ii-?ooiaiai aia?aoo, i?ieaine oa ?io? aeaoaeoe na?oeaaeo no?oeoo?,
ANAe, noeeuei?noue aei e?iaioa/?, iaoiaeo a?eae, i?aeaeaeoo o?onoaeeea
oa ?ioeo iciae nenoaiiiai o?aaeaiiy niieo/ii? oeaieie o ?iaee/?a).

Aei ?ino?oiaioaeueieo iaoiae?a ae?aaiinoeee AIN iaeaaeaoue:

1.Aio?iiiiao??y.

2.Rn-a?ao?/ia ianoaaeaiiy noaeia?a oa o?aaoa.

3.Aeeiaiiiao??y.

4.Aoiea?ae?ineii?/ia ianoaaeaiiy.

Aiae?coth/e on? a?aeiiino?, ye? ia?ii ia nueiaiaei?oi?e aeaiue o
na?oia?e iaaee/i?e e?oa?aoo?? c ieoaiue ae?aaiinoeee AIN, ie ae?eoee aei
aeniiaeo, ui iaia? /?oeiai oyaeaiiy i?i AIN ye naiino?eii? iicieia?/ii?
oi?ie. Naia ii nia? a?ia??ooeea?noue ia caaaeaee ? caoai?thaaiiyi,
iicanoaeiai? i?iyae AIN, a oaeiae eaai?aoi?i? ? ?ino?oiaioaeuei? caniae
ae?aaiinoeee inoaoi/ii ia aea/ai?, a o?, ui iathoue i?noea — ia
nenoaiaoeciaai?. Oea ni?e/eiy? “caieaeaio” ae?aaiinoeeo aeaiiai
neiae?iio. Cai?iiiiiaai? iaie e?eoa??? aeicaieythoue “caiiaieoe oeth
i?iaaeeio” ? aeathoue iiaeeea?noue iiaeyiooe ia AIN ia o?eueee ye ia
o?aaeaiiy iii?ii-?ooiaiai aia?aoo, aea e on?o iacaio?iaeueieo no?oeoo? a
oe?eiio. Ie??i oiai, aiie a?aeiinii i?ino?, aeinooii? ?
?aeiiaiaeothoueny aeey oe?ieiai eiea e?ea??a-ee?i?oeeno?a.

O YIII ?icae?e? aeena?oaoe?? ?ice?eaa?oueny ?ic?iaea i?eioeei?a
e?eoaaiiy AIN oa ?o iaa?oiooaaiiy. Iiooe i?ia?ai e?eoaaiiy i?ioiaeea o
iai?yieo ?o caeaoiino? iiceoeaii aieeaaoe ia ii?ooaiee neioac ? ?iciaae
eieaaaio ? ioeiiie?naoa?eae?a niieo/ii? oeaieie, a oaeiae ii?ooaiee
eeneioii-eoaeiee aaeain.

O ?iaio? iaaaaeai? ?acoeueoaoe e?eoaaiiy anei?a?iiaith eeneioith 32
oai?eo ia AIN i?ioyaii i?nyoey. Io?eiai? ?acoeueoaoe anoaiiaeee
aoeeaeioe/iee aieea anei?a?iiai? eeneioe, a naia: ciaioaiiy
ni?aa?aeiioaiiy ieeneaieo iaoaaie?o?a aei a?aeiiaeaieo (I??/iae – 0,83
aei e?eoaaiiy ? 0,42 i?ney e?eoaaiiy, Ia/iae – 1,84 aei e?eoaaiiy ? 0,78
i?ney e?eoaaiiy); ni?aa?aeiioaiiy I??/eae caeeoa?oueny ca?eueoaiei c
i?e/eie iecueeiai ci?noo eaeoaoo( I??/eae – 1,67 aei e?eoaaiiy ? 1,65
i?ney e?eoaaiiy). Ciaioaiiy ieenethaaeueieo aeanoeainoae ieacie
aiane?aeie e?eoaaiiy ? ?aaoeyoi?iith aaee/eiith, yea ni?yiiaaia ia
ia?aeeth/aiiy ae?eie?oe/ieo ?aaeoe?e ia aetheiiaiaaiac.

I?ney i?iaaaeaiiai eo?no e?eoaaiiy anei?a?iiaith eeneioith anoaiiaeaia
oaeiae ei?aeoe?y ?ioeo iieaciee?a, a naia: ca?eueoaiiy aeoeaiino?
IAAe-caeaaeii? iaeaoaeaa?ae?iaaiace (0,098+0,004 iiieue/n/ie aei
e?eoaaiiy ? 0,120+0,005 iiieue/n/ie i?ney e?eoaaiiy, ?<0,05) ? o?oeoiciae?oinoioace (0,102+0,005 iiieue/n/ie aei e?eoaaiiy ? 0,124+0,008 iiieue/n/ie i?ney e?eoaaiiy, ?<0,05); ciaioaiiy ni?aa?aeiioaiiy o?ie?a aei ae?noeueo?ae?a (0,90 aei e?eoaaiiy ? 0,68 i?ney e?eoaaiiy). Oaeei /eiii, aoeeaeioe/ia ae?y anei?a?iiai? eeneioe caaacia/oaaea ca?eueoaiiy a?aeiiaeaieo aeanoeainoae a oeaieiao ? ??aeeiao i?aai?cio, oiaoi ciaioaiiy yaeu aeeaeico o oai?eo ia AIN. Aiae?c ?acoeueoao?a aieeao anei?a?iiai? eeneioe ia iniiai? iieacieee iaoaaie?cio niieo/ii? oeaieie iieacaa: ciaioaiiy ienei?ie?io (1,71+0,04 iea/ie aei e?eoaaiiy ? 1,37+0,04 iea/ie i?ney e?eoaaiiy, ?<0,05), ciaioaiiy aeoeaiino? eieaaaiace (10,6+0,43 iiieue/n/ie aei e?eoaaiiy ? 9,21+0,34 iiieue/n/ie i?ney e?eoaaiiy, ?<0,05) oa aeanoace (14,52+0,20 iiieue/n/ie aei e?eoaaiiy ? 13,86+0,20 iiieue/n/ie i?ney e?eoaaiiy, ?<0,05), ca?eueoaiiy ?ia?a?oi?ii? aeoeai?no? (1,78+0,06 ia/ie aei e?eoaaiiy ? 2,31+ 0,12 ia/ie i?ney e?eoaaiiy, ?<0,05). Iaio niaoeeo?/i? aeey niieo/ii? oeaieie iaeo?aeueia oa eenea i?ioaace (Eaoainei Ae) cia/ii ia ci?ieeeny (?>0,05). Aeuaiaaaaeai? iieacieee aeaiiino?othoue
ei?aaoth/o ae?th anei?a?iiai? eeneioe ia oa?iaioi? oa ?ia?aeoi?i?
nenoaie niieo/ii? oeaieie, caaaeyee ye?e ciaioothoueny i?ioeane
?iciaaeo aieieienoeo niieoe (eieaaai, aeanoei).

Iaeiae, iacaaaeath/e ia aeuaaeeeaaeaia, iaiao?aeii ?icoi?oe, ui
anei?a?iiaa eeneioa i?e aeaiiiio caoai?thaaii? ia ? i?aia?aoii oaeaeei?
ae?? ?, ia aeeaey/enue ia io?eiai? iiceoeai? c?ooaiiy ia a?io?i?/iiio
??ai?, ca /ioe?e oeaei? aeuaicia/aii? oa?ai?? cia/ieo c?ooaiue a
iniiaieo ee?i?/ieo i?iyaao AIN ie ia niinoa??aaee.

Ianooiio aeine?aeaeoaaeueio a?oio neeaee 35 oai?eo ia AIN ia?aaaaeii c
noaeiaiaith oi?iith, ye? aiaeii/an c anei?a?iiaith eeneioith
iaea?aeoaaee eo?n ?oiaeiio — i?aia?aoo, yeee caeaoai i?aeneethaaoe
neioac eieaaaio ? ae?eiciai?iiae?eai?a, ciaiooaaoe ?o aeaa?aaeaoe?th oa
noeioethaaoe caoeni? aeanoeaino? ioeiiie?naoa?eae?a a?aeiinii
“aa?aneaii?” ae?? iacaio?iaeueieo oa?iaio?a. Io?eiai? ?acoeueoaoe
i?aaenoaaeai? a oaae.4.

Oaaeeoey 4

I?ioaie?oe/ia(iiieue/n/ie), ?ia?a?oi?ia (ia/ie) aeoeai?noue oa ci?no
ienei?ie?io (iea/ie) ? a?eea e?ia? (a/e)oai?eo ia AIN a aeeiai?oe?
e?eoaaiiy eiiieaenii “anei?a?iiaa eeneioa+?oiaeii”

Aeine?aeaeoaaeuei?

iieacieeeEiio?ieueOai?? (n = 35)p

aei e?eoaaiiy i?ney
e?eoaaiiyIenei?ie?i1,5+0,11,68+0,031,28+0,03?<0,05Eieaaaiaca8,05+0,3610, 58+0,458,11+0,27?<0,05Aeanoaca6,35+0,7814,27+0,629,31+0,50?<0,05Iaeo?aeu eia i?ioaaca2,05+0,126,13+0,645,98+0,46?>0,05Eaoainei
Ae8,65+0,7610,78+0,7610,26+0,44?>0,05?ia?a?oi?ia
aeoeai?noue1,69+0,131,81+0,062,64+0,08?<0,05A?eie66,51+1,7362,14+1,8068, 12+1,02?<0,05 I?ney e?eoaaiiy o oai?eo ia AIN anoaiiaeaii aeinoia??ia cieaeaiiy ??aiy ienei?ie?io, aeoeaiino? eieaaaiace ? aeanoace ia oii? cia/iiai i?aeaeuaiiy ?ia?a?oi?ii? aeoeaiino? ? ??aiy a?eea e?ia?. A?aecia/aeany oaeiae oaiaeaioe?y aei ciaioaiiy aeoeaiino? iaeo?aeueii? oa eenei? i?ioaac. ?acoeueoaoe ni?eueii? ae?? anei?a?iiai? eeneioe oa ?oiaeiio na?ae/eee i cia/ii a?eueoeo iiceoeaieo ci?iao iaoaaie?cio niieo/ii? oeaieie, iaoiiaeai? aaea ia o?eueee ciaioaiiyi ?iciaaeo eieaaaio, aea e ia?aaaaith i?ioean?a neioaco iaae i?ioeanaie ?iciaaeo. O iaoe?aio?a oe??? a?oie niinoa??aaeinue oaeiae cia/ia iie?ioaiiy aeeiai?ee ee?i?/ieo i?iya. Aea o?aaa caoaaaeeoe, ui yeui cieeiaiiy aai ciaioaiiy aieth a noaeiaao a?aecia/aei 90,0% oai?eo, oi ciaioaiiy ? cieeiaiiy aa?oaa?iaaiiiai aieth – o?eueee 46,67% oai?eo. O?oaeiiu? a ei?aeoe?? aieueiaiai neiae?iio o oe??? eaoaai??? oai?eo iiyniththoueny oei, ui i?e/eiith aieth o ieo ? ia o?eueee no?oeoo?ia ? ooieoe?iiaeueia ii?ooaiiy ca’yci/iiai aia?aoo, aea oaeiae ? ci?ie i’yciaiai ea?eano o?aaoa. Aeey ei?aeoe?? aa?oaa?iaaiieo i?iya?a o 20 oai?eo o caaaeueiee iaaeeeaiaioiciee eiiieaen aeeth/aany niaoe?aeueiee iaa?? e?eoaaeueieo o?ce/ieo ai?aa aeey ci?oeiaiiy i`yciaiai ea?eano aa?oiuei? iieiaeie ooeoaa, ui aeicaieeei niinoa??aaoe a?eueo ae?aaeaio iiceoeaio aeeiai?eo ee?i?/ieo i?iya?a (cieeiaiiy ? ciaioaiiy aa?oaa?iaaiiiai aieth a?aecia/aei 70,0% oai?eo), a oaeiae iie?ioaiiy iieaciee?a ?o/ii? ? noaiiai? aeeiaiiiao??? (?o/ia i?aaa – 24,86+1,82 aei e?eoaaiiy ? 29,32+2,04 i?ney e?eoaaiiy, ?<0,05; ?o/ia e?aa – 23,8+1,9 aei e?eoaaiiy ? 28,4+1,9 i?ney e?eoaaiiy, ?<0,05; noaiiaa – 44,12+4,2 aei e?eoaaiiy ? 51,1+3,6 i?ney e?eoaaiiy, ?<0,05). sse na?ae/eee iao? aeine?aeaeaiiy, iaeia c i?ia?aeieo i?noeue o oi?ioaaii? ee?i?/ieo i?iya?a c aieo na?oeaai-noaeeiii? nenoaie iin?aea? aaaaoi-noaeeiia aeenooieoe?y. Oiio, ii?yae c iaaeeeaiaioiciith aaceniith oa?ai??th (?oiaeii+anei?a?iiaa eeneioa), yea caeaoia aieeaaoe aaciina?aaeiuei ia ii?ooaiee iaoaaie?ci niieo/ii? oeaieie, ie ?aeiiaiaeo?ii aei eiiieaeno e?eoaaiiy oaeeo oai?eo aeiaeaaaoe eo?n iaai?oioa?ai??, ye o?c?ioa?aiaaoe/iiai caniao, caeaoiiai aieeaaoe ia ii?ooaio iae?iaiaeie?eiio ?aaoeyoe?th a a?e ciaioaiiy neiiaoe/ieo aieea?a. Aeine?aeio a?oio neeaee 32 oai?eo ia AIN c ia?aaaaith iicanoaeiaiaeo nea?a, cie?aia c aieo na?oeaai-noaeeiii? nenoaie (ea?ae?aea??, a?eoi??, i?enooie ia?ieneciaeueii? oao?ea?ae??, i?ieaine eeaiai?a, neieiiaeuei? noaie ? o.i.). Cieeiaiiy ea?ae?aea?e i?ney eo?no i?iaaaeaiiai e?eoaaiiy a?aecia/aei 22,71% oai?eo, ciaioaiiy aieth a ae?eyioe? na?oey - 68,17% oai?eo, ia a?aecia/aee ci?ie ?ioaineaiino? aieth/iai neiae?iio 9,09% oai?eo. I?ney e?eoaaiiy oaeiae ciaioeeeny nea?ae ia ii?ooaiiy ?eoio na?oeaai? ae?yeueiino?, eaa?euei?noue e?ia`yiiai oeneo, aieiaie?oae?iiy, ianoa?ii?noue niaee oa aeooioe, iacaaeiaieai?noue aaeeoo, oaeaeeo noiieai?noue, ui i?aeoaa?aeo? iae?iaeen?aaoeyoi?iee oa?aeoa? nea?a oa ?o ei?aeoe?th i?ae aieeaii iaai?oioa?ai??. Aeey ia’aeoea?caoe?? nooiaith neiiaoe/ieo eieeaaiue o oai?eo oe??? a?oie ?ic?aoiaoaaany aaaaoaoeaiee ?iaeaen Ea?aei (1–ae?anoiee/iee oene//anoioa ioeueno), yeee i?ney e?eoaaiiy ciaioeany iaeaea a 3 ?ace ( aei e?eoaaiiy - +12,4+ 0,3 ? i?ney e?eoaaiiy - + 4,02 +0,06, ?<0,05), ui na?ae/eoue i?i ciaioaiiy neiiaoeeioii?? o oai?eo i?ae aieeaii eo?no iaai?oioa?ai??. I?e aea/aii? iieaciee?a oeaio?aeueii? aaiiaeeiai?ee aeyaeaiee ei?aaoth/ee aieea ci?iiiai iaai?oiiai iiey (ciaioaiiy a?aenioeo oai?eo c a?ia?e?iaoe/iei oeiii e?iaiia?ao o 2,10 ?ace ? c a?iie?iaoe/iei oeiii – a 2,0 ?ace, aiane?aeie /iai e?euee?noue oai?eo c aoeeiaoe/iei oeiii e?iaiia?ao ca?eueoeeanue o 2,86 ?ace). A?aoiaoth/e aeineoue /anoa ii?aeiaiiy AIN c i?ieainii i?o?aeueiiai eeaiaio, aeyaeyeiny oe?eaaei ioe?ieoe nooi?iue ?aao?a?oaoe?? i?ney i?iaaaeaiiai eo?no e?eoaaiiy: 7,54+0,21ii aei e?eoaaiiy ? 7,12+0,18 ii i?ney e?eoaaiiy ( ?>0,05 ). Iacaaaeath/e ia oa, ui io?eiaia oaiaeaioe?y
aeoaea iaea, ie ana-oaee, o?aeoo?ii ?? ye iiceoeaiee ?acoeueoao,
a?aoiaoth/e neeaaei?noue ei?aeoe?? aaaaoueio niaaeeiaeo caoai?thaaiue
niieo/ii? oeaieie ? AIN cie?aia. Ie i?eionea?ii, ui i?e o?eaaeiio ?
?aaoey?iiio — aeae?eueea ?ac ia ??e — canoinoaaii? aeaiiai eiiieaeno,
aoaeo iiaea aooe cia/ii aeuee. Oea iiynith?oueny ni?eueiei aieeaii
?oiaeiio ? anei?a?iiai? eeneioe ia i?eniiaoicii ci?iaiee eeaiai (aacenia
e?eoaaiiy), a oaeiae iaeii/aniith ae??th iaai?oioa?ai?? ia
iae?iaiaeie?eiio aeenooieoe?th, oiaoi ii noo? ia iniiai?
ii?oiooieoe?iiaeuei? iaoai?cie oi?ioaaiiy i?ieaino.

AENIIAEE

1.Na?aae aei?ineiai ianaeaiiy i?aaeaiiiai ?aa?iio Oe?a?ie AIN
aeyaey?oueny o 1,70% ianaeaiiy. Aoaeue-yeeo noaoenoe/ii aaaiieo
?ic??ciaiue c ?iciianthaeaeaiino? AIN o in?a ??cii? noao? ia aeyaeaii.

2.Aaiaieia?/ia aeine?aeaeaiiy, i?iaaaeaia na?aae oai?eo oa ?o ?iaee/?a I
nooiaiy nii??aeiaiino? (aaoueee, ae?oe, n?ane) iieacaei, ui
a?ia?iia?euei?noue noaeia?a niaaeeo?oueny ii aooiniiii-aeii?iaioiiio
oeio c aeineoue aenieei ??aiai iaiao?aioiino? aaiioeio ? yaey? niaith
aeineoue neeueiee oaeoi?, ui i?iaieo? oi?ioaaiiy AIN ye naiino?eii?
iicieia?/ii? oi?ie. Aea/aiiy nenoaie oeaieiii? a?noinoi?niino? oai?eo ia
AIN (HLA- ? DR-oeioaaiiy) iieacaei, ui iaea?eueoee nooi?iue
anioe?aoeaiiai ca`yceo niinoa??aa?oueny na?aae aioeaai?a HLA B8, A35 ?
DR1 ( ?acoeueoao noaoenoe/ii aeinoia??iee).

3.Acoaiiaeaii, ui o oai?eo ia AIN ii?ooaia ??aiiaaaa i?ae iniiaieie
aea?eaaoaie eieaaaio (ien?i?ie?i), niaoeeo?/ieie iacaio?iaeueieie
oa?iaioaie (eieaaaiaca, aeanoaca) oa ?o ?ia?a?oi?aie, i?i ui na?ae/eei
ca?eueoaiiy ??aiy ienei?ie?io, cia/ia i?aeaeuaiiy aeoeaiino? oa?iaio?a c
iii??iei ca?eueoaiiyi ?ia?a?oi?ii? aeoeaiino?, cieaeaiiy e?eueeino?
a?eea o ne?iaaooe? e?ia?. Io?eiai? aeai? na?ae/aoue i?i ?iciaae ?
aeeno?io?/i? ci?ie a?eeiaeo eiiiiiaio?a niieo/ii? oeaieie.

4.Anoaiiaeaii ii?ooaiiy eeneioii-eoaeiiai aiiainoaco o oai?eo ia AIN,
i?i ui na?ae/eei onoiaiiy ??aiiaaae o a?e iaoaaie?/iiai aeeaeico c
ia?aaaaeiith eiiiainaoe??th oeueiai noaio oeyoii ?icaeoeo aoi?eiiiai
iaoaaie?/iiai aoeeaeico, yeee i?ecaiaeeoue aei a?eeiai? iaaeinoaoiino?
niieo/ii? oeaieie c ??ciiiai?oieie ee?i?/ieie neiioiiaie
(a?ia?iia?euei?noue, inoaiii?ic, i?ieaine ? o.i.). Oey iaaeinoaoi?noue
niieo/ii? oeaieie iaoiiaeaia ia o?eueee ao?aoith a?eea eieaaaiiaeo oa
aeanoeiiaeo no?oeoo?, aea oaeiae ? ao?aoith eiiiiiaio?a
ioeiiie?naoa?eaeiiai eiiieaeno i?ii?aeii? ?a/iaeie.

5.Ioe?iea noaio iii?ii-?ooeeaiai aia?aoo oai?eo ia AIN iieacaea, ui
nea?ae caiaeeeeny o ieo , a oe?eiio, aei aieth o noaeiaao (53,06%) ?
o?aao? (46,94%), a aiaiiac? i?aaaethaaee /ano? (32,3%) ? caeee? aeaeoe
(11,5%), ooeiaeaeaiiy ca`ycie oa nooiaeeee?a (30,8%), a i?e
?aioaaiieia?/iiio aeine?aeaeaii? aeyaeai? ?aii?e ?icaeoie inoaia?o?ic?a
? inoaioiiae?ico o?aaoa.

6.Aiae?c noaio na?oeaai-noaeeiii? nenoaie iieacaa, ui aieiai? nea?ae
caiaeeeeny aei aieth a ae?eyioe? na?oey (72,34%), ii?ooaiith ?eoio
na?oeaai? ae?yeueiino? (57,45%), eaa?eueiino? a?oa??aeueiiai oeneo
(60,63%). Ca?aeii c iaoeie aeaieie aeacai? iciaee o oeeo oai?eo
iaoiiaeai? aaaaoi-noaeeiiei aeenaaeainii ?c a?ia?neiiaoeeioii??th,
i?e/iio oa?aeoa? aaaaoaoeaiiai caaacia/aiiy ? oaeiae niaaeeiai
iaoiiaeaiith iciaeith, ui i?aeoaa?aeo?oueny iaoeie aaiaaeia?/ieie
aeine?aeaeaiiyie. O?aaeaiiy no?oeoo? na?oey o oai?eo ia AIN ? iciaeith
caaaeueii? niieo/iioeaieiii? aeenieac?? ? ca aeaieie aoiea?ae?ia?ao??
iaea?eueo iioe?aieie ? ianooii?: IIE (53,31%), IOE (11,54), ii?aeiaiiy
IIE c IOE (15,38%), aeaoaeoe i?aeoeoii/eiai? (9,23%) ? iaaei?aaena?aeii?
(9,23%) ia?aoeiie, ?icoe?aiiy aeoae ai?oe (37,69%).

7.AIN a?ae??ciy?oueny oaeiae aaeeeith ??ciiiai?oi?noth ee?i?/ieo
i?iya?a c aieo ?ioeo i?aai?a oa nenoai: iaoieia?y i?aaia ci?o (50,0%),
oea?aa?iaaneoey?i? ?oai?/i? ?iceaaee (9,23%), iiouaiiy iaoee oa i?oae
(11,1%), iaoieia?y aeia/aaeioneaeueii? nenoaie (9,52%), a?eae? (8,46%),
noeeuei?noue aei e?iaioa/? (4,62%), a?ia?aeano?/i?noue oe??e (3,09%),
i?e/iio eiaeia c ieo, iaa?oue iaeiaio iioe?aia, iiaea aeoiaeeoe ia
ia?oee ieai o eiaeii? iniaenoino? ? aecia/aoe aieiaio neiioiiaoeeo ??
ee?i?/ii? ea?oeie.

8.A?aenooi?noue /?oei? ?iciaaeiaaiino? iiiyooy “aaia?ae?ciaai?noue” oa
“ae?aaeai?noue” a aeiaaeeao ioe?iee nooiaiy a?ia?iia?eueiino? ca
e?eoa??yie P.Beighton ? F.Horan cioneee ian cai?iiiioaaoe naith ioe?ieo
a?ia?iia?eueiino? (ye iciaee) c aecia/aiiyi iiiyooy “ae?aaeaiino?” ye
nooiaiy a?ia??ooeeaino? ? “?iciianthaeaeaiino?” ye e?euee?niiai
caeo/aiiy o i?ioean niieo/iioeaieiieo no?oeoo?.

9. Nenoaiaoeciaai? ? ai?iaaaeaeai? e?eoa??? ae?aaiinoeee AIN
(ye caoai?thaaiiy), ye? ii?aeiothoue ioe?ieo a?ia??ooeeaino?
aeuaicia/aiei niiniaii c ee?i?/ieie, eaai?aoi?ieie ? ?ino?oiaioaeueieie
iaoieia?/ieie iciaeaie. E?eoa??? aeicaieythoue o?aooaaoe a?eueo oe?iea
eiei iaoieia?/ieo iciae, a oaeiae aeyaeoe noaeiaia? oa iicanoaeiaia?
oi?ie o?aaeaiiy iacaio?ie.

10.Aiae?c iieaciee?a oa?iaioieo ? ?ia?a?oi?ieo nenoai niieo/ii?
oeaieie, a oaeiae eeneioii-eoaeiiai aaeaino o i?ioean? e?eoaaiiy
oai?eo ia AIN anei?a?iiaith eeneioith ? ?oiaeiiii iieacaa, ui ia oii?
iie?ioaiiy iieaciee?a eeneioii-eoaeiiai aaeaino, iaoiiaeaiiai ae??th
anei?a?iiai? eeneioe, ?oiaeii aieiae?? i?ioaeoi?iith ae??th ia iniiai?
no?oeoo?i? eiiiiiaioe niieo/ii? oeaieie ? aeicaiey? ci?oeieoe ??
ii/eiaiiy uiaei cieaeaiiy ?iciaaeo iie?naoa?eaeieo oa a?eeiaeo
eiiiiiaio?a niieo/ii? oeaieie.

12. Aiae?c ?acoeueoao?a canoinoaaiiy iaai?oioa?ai?? ia ?aoeaeniaaiio
ciio na?oey o oai?eo ia AIN c ia?aaaaith na?oeaai-noaeeiii? neiioiiaoeee
iieacaa cia/ia ciaioaiiy ea?ae?aea?e ? ii?ooaiue ?eoio, ui aeicaiey? iai
?aeiiaiaeoaaoe aeaiee iaoiae e?eoaaiiy aeey oai?eo ia AIN c ia?aaaaith
na?oeaai-noaeeiieo ?iceaae?a.

13.Aiae?c io?eiaieo ?acoeueoao?a o i?ioean? e?eoaaiiy oai?eo ia AIN c
ia?aaaaith aa?oaa?iaaiieo i?iya?a c aeeth/aiiyi a eiiieaen “anei?a?iiaa
eeneioa + ?oiaeii” eo?no EOE iieacaa cia/ia ciaioaiiy aa?oaa?aea?e ?
iie?ioaiiy iieaciee?a aeeiaiiiao???, ui iia`ycaii ?c ci?oeiaiiyi
i’yciaiai ea?eano o?aaoa.

I?AEOE*II ?AEIIAIAeAOeI?

1.I?aenoiiaoth/e io?eiai? aeniiaee, ?aeiiaiaeo?oueny aei aeei?enoaiiy o
oe?ie?e i?aeoeoe? aeania noenea aecia/aiiy a?ia?iia?eueiiai neiae?iio:

AIN – oea niaaeeiaa nenoaiia caoai?thaaiiy niieo/ii? oeaieie, yea
oniaaeeiao?oueny ii aooiniiii-aeii?iaioiiio oeio c aenieei ??aiai
iaiao?aioiino?, a iniia? yeiai eaaeaoue iaoaaie?/i? ii?ooaiiy
niieo/iioeaieiieo niieoe, ye? iaoiiaeai? ?icaeoeii aeeaeico c
eiiiainaoi?iei aoeeaeicii, ui i?eaiaeeoue aei ca?eueoaiiai ?iciaaeo ?
ii?ooaiith neioaco eieaaaia ? iaoiiaeth? i?aeaeuaio noaeiaiao
?ooeea?noue, o?aaeaiiy iii?ii-?ooiaiai aia?aoo, a oaeiae iicanoaeiaia?
i?iyae (o?aaeaiiy na?oeaai-noaeeiii? nenoaie, i?aaia ci?o, aaaaoaoeaii?
ia?aiai? nenoaie oa ?i.).

2.On?o oai?eo c a?ia?iia?euei?noth noaeia?a iaiao?aeii i?aeaeaaaoe
?aoaeueiiio ?aaiaoieia?/iiio ianoaaeaiith c iaoith aeyaeaiiy o ieo iciae
o?aaeaiiy iii?ii-?ooiaiai aia?aoo, iaea?eueo iioe?aieie c yeeo
yaeythoueny: iie?a?o?aea??, aeaeoe noaeia?a, n?iiaeoe, ooeiaeaeaiiy
ca’ycie ? nooiaeeee?a, aa?oaa?iaaii? i?iyae, noeeuei?noue aei ia?aeiio
e?noie, ?aii? inoaioiiae?ice oa inoaia?o?ice.

3.O uiaeaii?e iaaee/i?e i?aeoeoe? iaiao?aeii caaaeaoe, ui AIN
a?aecia/a?oueny cia/iei iie?ii?o?ciii ee?i?/ieo i?iya, ye? iaoiiaeai?
aeinoaoiueith e?euee?noth ii?oieia?/ieo ??ciiaeae?a niieo/ii? oeaieie
(o?yu, oe??a, eeaiaie na?oey, noaeeie, aeaye? no?oeoo?e i?aaia ci?o?
o.ae.) Iaea?eueoo oaaao iaiao?aeii i?eae?eyoe ea?ae?iaaneoey?iei
iaoieia?/iei iciaeai – a?eoi??, neieiiaeuei? noaie, i?ieaine eeaiai?a,
?icoe?aiiy aeoae ai?oe, a?ae?eae oi?ae c oi?ioaaiiyi ae?aaeaii?
?aao?a?oaoe?? ? o.ae.

4.A?aoiaoth/e, ui ae?aaiinoeea AIN ia aeaiiio aoai? eiai aea/aiiy
neeaaea? cia/i? o?oaeiiu?, aeioe?eueii aeei?enoiaoaaoe cai?iiiiiaai?
e?eoa??? ae?aaiinoeee oeueiai caoai?thaaiiy, ui aeeth/athoue
nenoaiaoeciaaio ioe?ieo ee?i?/ieo, eaai?aoi?ieo ? ?ino?oiaioaeueieo
iaoieia?/ieo iciae.

C iaoith aeyaeaiiy a?ia??ooeeaino? ye iciaee aeioe?eueii aeei?enoiaoaaoe
cai?iiiiiaaiee iaoiae ioe?iee a?ia??ooeeaino? noaeia?a, yeee ? i?inoei,
ia iio?aao? niaoe?aeueii? aia?aoo?e ? iiaea aooe aeei?enoaiee iaa?oue a
aiaoeaoi?ieo oiiaao.

5.Aeey e?eoaaiiy oai?eo ia AIN ne?ae ?aeiiaiaeoaaoe ni?eueia
canoinoaaiiy anei?a?iiai? eeneioe ? ?oiaeiia ca aeeeaaeaieie aeua
noaiaie. E?eoaaiiy ? iaoiaaiaoe/iei ? ia? aooe o?eaaeei (aeae?eueea
eo?n?a ia ??e).

6.Aeey oai?eo c ia?aaaaith i?iya?a c aieo iii?ii-?ooiaiai aia?aoo
(iniaeeai o?aaoa) o eiiieaen e?eoaaiiy “anei?a?iiaa eeneioa+?oiaeii”
?aeiiaiaeo?oueny aeiaeaaaoe EOE ii cai?iiiiiaai?e iaoiaeeoe? c iaoith
ci?oeiaiiy eainoeueii-ca’yceiaiai aia?aoo oa i’yciaiai ea?eano.

Aeey oai?eo c ia?aaaaith i?iya?a c aieo na?oeaai-noaeeiii? nenoaie
(iniaeeai aaaaoaoeaia aeen?aaoeyoe?y, i?ieaine) ?aeiiaiaeo?oueny
aeeth/aoe aei eiiieaeno “anei?a?iiaa eeneioa+?oiaeii” eo?n
iaai?oioa?ai??, yea caeaoia ii?iae?coaaoe aaaaoaoeaiee ae?naaeain o
aeaii? eaoaai??? oai?eo.

NIENIE IIOAE?EIAAIEO I?AOeUe

CA OAIITH AeENA?OAOe??

1.Cieioa??aa-Aiae?aaaa I.A. Aeia?iiaeeueiue neiae?ii: yoeieiaey,
eeeieea, ea/aiea // Iaaeeoeeineay ?aaaeeeoaoeey, eo?i?oieiaey e
oeceioa?aiey.- 1996.-?4.- N.47-50.

2.Cieioa??aa-Aiae?aaaa I.A. Aeia?iiaeeueiue neiae?ii: eeeieea,
aeeaaiinoeea, ianeaaenoaaiiua iaoaieciu // Aanoiee i?iaeai nia?aiaiiie
iaaeeoeeiu.- 1995.- ?5.- N.31-33.

3.Cieioa??aa-Aiae?aaaa I.A. Oece/aneay ?aaaeeeoaoeey aieueiuo n
aeia?iiaeeueiui neiae?iiii // Iaaeeoeeineay ?aaaeeeoaoeey, eo?i?oieiaey
e oeceioa?aiey.- 1997.- ?4.- N.39-41.

4.Cieioa??aa-Aiae?aaaa I.A. Ii?oi-ooieoeeiiaeueiua iniaaiiinoe
na?aea/ii-ninoaeenoie nenoaiu o aieueiuo aeia?iiaeeueiui neiae?iiii
// Oe?aeineee ea?aeeieiae/aneee aeo?iae.- 1997.- Aei.II,?4.-
N.56-57.

5.Cieioa?ueiaa-Aiae???aa I.A. Noai iaoaaie?/ii? nenoaie
?aaoeyoe?? eeneioii-eoaeiiai aiiainoaco o oai?eo a?ia?iia?eueiei
neiae?iiii // Iaeanueeee iaaee/iee aeo?iae.-
1997.- ?2(43).- N.17-19.

6.Cieioa?ueiaa-Aiae???aa I.A. Eeiiiei-iino?oiaioaeueii iciaee
o?aaeaiiy na?oeaai-noaeeiii? nenoaie o oai?eo ia aiia?iiaieueiee
neiae?ii // I?aeoe/ia iaaeeoeeia.- 1999.- ?1-2.- N.45-47.

7.Cieioa??aa-Aiae?aaaa I.A. Ea/aiea aeia?iiaeeueiiai neiae?iia n
i?eiaiaieai iaaieoioa?aiee //Iaaeeoeeineay ?aaaeeeoaoeey, eo?i?oieiaey e
oeceioa?aiey.- 1998.- ? 3(15).- N.66.

8.Cieioa?ueiaa-Aiae???aa I.A. Noai iii?ii-?ooiaiai aia?aoo o
oai?eo ia a?ia?iia?eueiee neiae?ii // Iaaee/i? ia?niaeoeae.- 1998.-
o.III,?1.- N.60-62.

9.Cieioa??aa-Aiae?aaaa I.A. Ninoiyiea eeaiaiiiai aiia?aoa
na?aeoea o aieueiuo aeia?iiaeeueiui neiae?iiii e eo ?iaenoaaiieeia //
Oe?aeineee ea?aeeieiae/aneee aeo?iae.- 1998.- ? 2.- N.56-57.

10.Cieioa??aa-Aiae?aaaa I.A. Iniaaiiinoe iaoieiaee eiaee o
aieueiuo aeia?iiaeeueiui neiae?iiii // Aea?iaoieiaey e aaia?ieiaey.-
1998.- ?1.-N.40-41.

11.Cieioa?ueiaa-Aiae???aa I.A. ?iciianthaeaeai?noue ? noaoaa?
iniaeeaino? a?ia?iia?eueiiai neiae?iio // Iaeanueeee iaaee/iee aeo?iae.-
1999.- ?1(51).- N.43-45.

12.Cieioa??aa-Aiae?aaaa I.A. Iooaeueiieiae/aneay iaoieiaey o
aieueiuo n aeia?iiaeeueiui neiae?iiii // Iooaeueiieiae/aneee aeo?iae.-
1998.- ?1.- N.63-65.

13.Cieioa?ueiaa-Aiae???aa I.A. Aiae?c ee?i?ei-aaiaaeia?/ieo
aeine?aeaeaiue o oai?eo ia a?ia?iia?eueiee neiae?ii // Iaeanueeee
iaaee/iee aeo?iae.- 1998.- ?1(45).-N.43-44.

14.Cieioa?ueiaa-Aiae???aa I.A. ?acoeueoaoe e?eoaaiiy oai?eo ia
a?ia?iia?eueiee neiae?ii ?c canoinoaaiiyi anei?a?iiai? eeneioe
// Iaeanueeee iaaee/iee aeo?iae.- 1999.- ? 2.- N.29-31.

15.Cieioa??aa-Aiae?aaaa I.A. Eco/aiea eiioiieiae/aneiai noaoona o
aieueiuo aeia?iiaeeueiui neiae?iiii // A?niee i?iaeai a?ieia?? ?
iaaeeoeeie.- 1999.- ?4.- N.33-35.

16.Cieioa??aa-Aiae?aaaa I.A. Eeeie/aneay aeeaaiinoeea aeia?iiaeeueiiai
neiae?iia // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.- 1999.- ?5.-
N.100-102.

17.Cieioa??aa-Aiae?aaaa I.A. Eco/aiea iaoaaieecia niaaeeieoaeueiie oeaie
o aieueiuo aeia?iiaeeueiui neiae?iiii // Aanoiee ii?neie
iaaeeoeeiu.- 1999.- ?1.- N.20-22.

18.Cieioa?ueiaa-Aiae???aa I.A. Nenoaii?noue o?aaeaiiy niieo/ii? oeaieie
o oai?eo ia a?ia?iia?eueiee neiae?ii // Journal of the Ukrainian
Medical Assotiation of North America, Inc.- 1999.- ?143.

19.Cieioa??aa-Aiae?aaaa I.A. Ia?ooaiea iii?ii-aeaeaaoaeueiiai aiia?aoa o
aieueiuo n aeia?iiaeeueiui neiae?iiii
// Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.- 1995. ?1
(aeiaeaoie).- N.97.

20.Cieioa??aa-Aiae?aaaa I.A., sseeiaiei A.A. Ia?ooaiea
?eoia na?aeoea o aieueiuo n aeia?iiaeeueiui neiae?iiii
// Aanoiee a?eoiieiaee.-
Naieo-Iaoa?ao?a.- 1995.- ?4.- N.1082-1083.

21.Cieioa??aa-Aiae?aaaa I.A., Ci?eia I.E. Ninoiyiea
eeaiaiiiai aiia?aoa o aieueiuo n nenoaiiui ii?aaeaieai
niaaeeieoaeueiie oeaie // Aanoiee a?eoiieiaee.-
Naieo-Iaoa?ao?a.- 1995.- ?4.- N.1084-1085.

22.Cieioa??aa-Aiae?aaaa I.A. E aii?ino i niaaeeieoaeueiioeaiiuo
aeenieaceyo // Iaoa?eaeu neiiiceoia ii i?ioanneiiaeueiie e no?aoiaie
iaaeeoeeia.- Iaeanna.- 1994.- N.12.

23.Cieioa??aa-Aiae?aaaa I.A., Ci?eia I.E. Na?aea/ii-ninoaeenoua
i?iyaeaiey o aieueiuo aeia?iiaeeueiui neiae?iiii // Iaoa?eaeu II
Oe?aeineie iao/i.-i?aeo. eiioa?aioeee “Aeooaeueiua aii?inu ea?aeeieiaee
e i?aaiecaoeee ea?aeeieiae/aneie iiiiue ianaeaieth”.- Iaeanna.- 1994.-
N.120.

24.Cieioa??aa-Aiae?aaaa I.A., Ci?eia I.E. Eciaiaiey ni noi?iiu
na?aea/ii-ninoaeenoie nenoaiu o aieueiuo n aeia?iiaeeueiui neiae?iiii
// Iaoa??aee II Oe?a?inueei? iaoe.-i?aeo. eiioa?aioe?? c
iaa?aeeeaaeii? aeiiiiiae “Aeooaeuei? ieoaiiy iaa?aeeeaaeii? aeiiiiiae”.-
Iaeana.- 1994.- N.122-123.

25.sseeiaiei A A., Cieioa??aa-Aiae?aaaa I.A. I?ioeeaeoe/aneia
ianeaaeiaaiea aieueiuo n aeia?o?ioeae ieiea?aea ?acee/iiai aaiaca a
caaeneiinoe io iannu oaea // Iaoa?eaeu iao/i.-i?aeo. eiioa?aioeee
“Aii?inu i?ioeeaeoeee”.- Iaeanna.- 1995.- N.49-50.

26.Cieioa??aa-Aiae?aaaa I.A. Aa?oaa?iaaiiay neiioiiaoeea o
aieueiuo n aeia?iiaeeueiui neiae?iiii // Iaoa?eaeu ?ani.neiiiceoia,
iina.95-eaoeth aeaae.ssneiianeiai I.A. “Aeooaeueiua aii?inu
?aaiaoieiaee”.- Iaeanna.- 1995.-N.35-36.

27.Cieioa??aa-Aiae?aaaa I.A. Ninoiyiea eiioiieiae/aneie ?aaeoeaiinoe o
aieueiuo n aeia?iiaeeueiui neiae?iiii // Ca.iaoe.i?., i?enay/aiee
95-??//th Iaeanueeiai aea?aeaaiiai iaae. oi?aa?neoaoo “Aeooaeuei?
ieoaiiy aioo??oi?o oai?ia”.- Iaeana.- 1996.- N.73-75.

28.Cieioa??aa-Aiae?aaaa I.A. Eeeie/aneay aeeaaiinoeea
aeia?iiaeeueiinoe nonoaaia // Ca.iaoe.i?., i?enay/aiee 95-??//th
Iaeanueeiai aea?aeaaiiai iaae.oi?aa?neoaoo “Aeooaeuei? ieoaiiy
aioo??oi?o oai?ia”.- Iaeana.- 1996.- N.75-77.

29.Cieioa??aa-Aiae?aaaa I.A. E aii?ino i aeia?iiaeeueiii
neiae?iia // Ca.iaoe.i?. “I?iaeaie iaaeaaiaeee aeui? iaaee/ii?
ina?oe o aocao Oe?a?ie”.- Iaeana.- 1997.- N.358-361.

30.Cieioa??aa-Aiae?aaaa I.A., Caeaoiaa E.A. Eiioiieiae/aneea
i?iyaeaiey o aieueiuo n aeia?iiaeeueiui neiae?iiii // Iaoa?eaeu iaaeae.
iao/i.-i?aeo. eiio-oeee “Iiaia a i?ioeeaeoeea, aeeaaiinoeea e ea/aiee
caaieaaaiee”.– Iaeanna.- 1996.– N.27.

31.Cieioa??aa-Aiae?aaaa I.A. Aaiaoe/aneea aniaeou aeia?iiaeeueiiai
neiae?iia // Iaoa?eaeu thaeeaeiie iao/i.-i?aeo. eiioa?aioeee,
iinayuaiiie 75-eaoeth eaoaae?u oa?aiee 1 Eeaaneie iaaeeoeeineie
aeaaeaiee iineaaeeieiiiie iiaeaioiaee “Aeooaeuei? i?iaeaie aioo??oiuei?
iaoieia?? oa i?neyaeeieiiii? i?aeaioiaee e?ea??a — oa?aiaao?a”.–
Eeaa.-1996.– N.145-147.

32.Cieioa?ueiaa-Aiae???aa I.A. I?i ieoaiiy niaaeeiaino? a?ia?iia?eueiiai
neiae?iio // Iaoa??aee ?? Iaoe?iiaeueiiai eiia?ano ?aaiaoieia?a
Oe?a?ie.– Ee?a.- 1997.– N.92.

33. Cieioa?ueiaa-Aiae???aa I.A., sse?iaiei I.I. Iniaeeaino? i?io?eaiiy
a?ia?iia?eueiiai neiae?iio o ae?iie // Iaoa??aee ?? Iaoe?iiaeueiiai
eiia?ano ?aaiaoieia?a Oe?a?ie.– Ee?a.- 1997.– N.92.

34. Cieioa??aa-Aiae?aaaa I.A. Nonoaaiua e aianonoaaiua i?iyaeaiey
aeia?iiaeeueiiai neiae?iia // Na. iao/i. o?. “Aeooaeueiua i?iaeaiu
iaoieiaee”. – Iaeanna.- 1997.– o.1.– N.43-46.

35. Cieioa??aa-Aiae?aaaa I.A. Iaoaieciu ?acaeoey iaoieiae/aneiai
inoaiii?ica o aieueiuo aeia?iiaeeueiui neiae?iiii // Iaoa?eaeu II
iao/i.-i?aeo. eiioa?aioeee n iaaeaeoia?iaeiui o/anoeai “Inoaiii?ic:
yieaeaieieiaey, eeeieea, aeeaaiinoeea, i?ioeeaeoeea e ea/aiea”.-
Eueaia.- 1997.– N.41-42.

36. Cieioa??aa-Aiae?aaaa I.A. Yieaeaieieiae/aneea aniaeou
aeia?iiaeeueiiai neiae?iia // Iao-eu ?anioae. iao/i.-i?aeo. eiio-oeee n
iaaeaeoi. o/anoeai “?ieue caaaeueiii?aeoeeoth/iai e?ea?y o ?ica’ycaii?
i?iaeai i?io?eaeoeee ia?ioaeoe?eieo caoai?thaaiue”.– Oa?ueeia.- 1997.-
N.27-28.

37. Cieioa?ueiaa-Aiae???aa I.A., Ci??ia I.?. Neiioiiaoeea o?aaeaiiy
iii?ii-?ooiaiai aia?aoo i?e a?ia?iia?eueiiio neiae?ii?
// 63-y i?aenoieiaa nooaeaionueea iaoeiaa eiioa?aioe?y.-
Iaeana.– 1994.– N.81.

38. Cieioa??aa-Aiae?aaaa I.A. Na?aea/ii-ninoaeenoua i?iyaeaiey o
aieueiuo n aeia?iiaeeueiui neiae?iiii // Oacenu aeieeaaeia thaeeaeiie
eiioa?aioeee, iinayu. 10-eaoeth Othiaineiai IEE eeei. e i?io.
ea?aeeieiaee.- Othiaiue.- 1995.– N.16.

39. Cieioa?ueiaa-Aiae???aa I.A. Ee?i?/i? i?iyae a?ia?iia?eueiiai
neiae?iio // Oace aeiiia?aeae VI Eiia?ano na?oiai? oaaea?aoe?? oe?.
e?ea?nueeeo oiaa?enoa.–Iaeana.- 1996.– N.189.

40.Cieioa??aa-Aiae?aaaa I.A., Eei/ei A.A. ?aioaaiieiae/aneia
enneaaeiaaiea iicaiii/ieea o aieueiuo aeia?iiaeeueiui neiae?iiii
// Oacenu aeieeaaeia iao/i.-i?aeo. eiioa?aioeee,
iinayu?iiie 99-eaoeth aeaae.I.A.ssneiianeiai.-
Iaeanna.- 1999.- N.19.

AIIOAOe?ss

Cieioa?ueiaa-Aiae???aa I.A. A?ia?iia?eueiee neiae?ii (iaoai?cie
?icaeoeo, ee?i?ei-eaai?aoi?ia ae?aaiinoeea, i?eioeeie e?eoaaiiy).–
?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo
iaoe ca oaoii 14.01.12 – ?aaiaoieia?y. ?iinoeooo
ea?ae?ieia?? ?i.
aeaae.I.Ae.No?aaeanea AII Oe?a?ie, Ee?a,1999.

O ?iaio? iaaeai? ?acoeueoaoe aea/aiiy a?ia?iia?eueiiai neiae?iio
(ieoaiiy niaaeeiaino?, iaoaaie?cio niieo/ii? oeaieie, ee?i?/ieo i?iya,
ae?aaiinoeee oa e?eoaaiiy). Aea/aiiy neiioii?a aeicaieeei aeae?eeoe
eaaeo ? ae?aaeaio oi?io AIN (ii nooiaith o?aaeaiino?), iioe?aio ?
eieaeueio (ii e?eueeino? eieae?caoe?e niieo/iioeaieiii? ae?nieac??), c
ia?aaaaith o?aaeaiiy iii?ii-?ooiaiai aia?aoo (noaeiaiaa oi?ia) ?
iicanoaeiaiaa, eiee ii?yae c iaoieia?/iith a?ia??ooeea?noth noaeia?a
a?aecia/aeenue iciaee o?aaeaiiy niieo/ii? oeaieie ?ioeo nenoai. Aea/aiiy
niaaeeiaino? anoaiiaeei aeii?iaioiee oei oniaaeeoaaiiy c aenieith
iaiao?aioi?noth, a oaeiae aaiaoe/i? ia?ea?e A8, A35 oa DR1. Ia iniia?
ee?i?/ieo i?iya?a, eaai?aoi?ieo oa ?ino?oiaioaeueieo iciae, aia?oa
cai?iiiiiaai? ae?aaiinoe/i? e?eoa??? aeey AIN. Cai?iiiiiaaii aeae?eueea
e?eoaaeueieo eiiieaen?a, ye? ii?aeiothoue aacenio oa?ai?th (?oiaeii,
anei?a?iiaa eeneioa) c neiioiiaoe/iith (iaai?oioa?ai?y, EOE) aeey oai?eo
c ia?aaaaith aeayeeo oi?i.

Eeth/ia? neiaa: A?ia?iia?eueiee neiae?ii, niaaeeia?noue, iaoaaie?ci
niieo/ii? oeaieie, ee?i?/i? i?iyae, e?eoa??? ae?aaiinoeee, e?eoaaiiy.

SUMMARY

Zolotareva-Andreeva N.A. Hypermobile syndrome (development,
clinical-laboratory diagnosis and treatment principles). – Manuscript.

Thesis for doctor’s degree by specialty 14.01.12 – reumatology.
Strazhesko Institute of Cardiology of Scientific Iedical Academy, Kiev,
1999.

The results of hypermobile syndrom (HMS) investigation (the problems of
inheritance, metabolism of connective tissue, clinical manifestation,
diagnosis and treatment) are presented in the work.. Analysis symptoms
permitted to distinguish between the light and pronounced forms of HMS
(on the basis severity of manifestations), between the widely spread and
local form (on the basis of connective tissue dysplasia foci number),
and between those ones with prevalence of defect in skeleton and joint
(jointal form) and extrajointal form which were characterised by not
only joint hypermobility but by connective tissue of other system
involvement as well. The heredity investigstion revealed the dominant
type of symptoms inheritance and their high penetration as well as
determined genetic markers B8, B35 and DR1. It is first time when
diagnostic criteria of HMS on the basis of clinical manifestation of
disease and laboratory and instrumental investigation data are proposed
and classified. Several complexes for treatment based on combination of
basic therapy (rumalon, ascorbic acid) along with syptomatic therapy
(magnetic therapy, complex of physical exercises) were propose for
patients with different form forms of HMS .

Key words: Hypermobile syndrome, heredity, metabolism of connective
tissue, clinical signs, diagnostical criteria, treatment.

AIIIOAOeEss

Cieioa??aa-Aiae?aaaa I.A. Aeia?iiaeeueiue neiae?ii (iaoaieciu ?acaeoey,
eeeieei-eaai?aoi?iay aeeaaiinoeea, i?eioeeiu ea/aiey).- ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a
iaaeeoeeineeo iaoe ii niaoeeaeueiinoe
14.01.12–?aaiaoieiaey. Einoeooo ea?aeeieiaee ei.
aeaae.I.Ae.No?aaeanei AII Oe?aeiu, Eeaa,1999.

A ?aaioa i?aaenoaaeaiu ?acoeueoaou eco/aiey aeia?iiaeeueiiai neiae?iia –
ianeaaenoaaiiiai caaieaaaiey niaaeeieoaeueiie oeaie, i?iyaeythuaainy
aeia?iiaeaeaeiinoueth nonoaaia a ni/aoaiee n ii?aaeaieai
iii?ii-aeaeaaoaeueiiai aiia?aoa. O 130 aieueiuo AIN eco/aeenue aii?inu
ianeaaenoaaiiinoe, aaiaoe/aneeo ia?ea?ia, ia?ooaiee iaoaaieecia
niaaeeieoaeueiie oeaie e eeneioii-uaei/iiai ?aaiiaaney, eeeie/aneeo
aa?eaioia oa/aiey, e?eoa?eaa aeeaaiinoeee e i?eioeeiia ea/aiey).
Eco/aiea neiioiiia iicaieeei auaeaeeoue e?aeoth e au?aaeaiioth oi?io AIN
(ii noaiaie oyaeanoe), ?ani?ino?ai?iioth e ia?ani?ino?ai?iioth (ii /eneo
eieaeecaoeee niaaeeieoaeueiioeaiiie aeenieacee), n i?aeiouanoaaiiui
ii?aaeaieai iii?ii-aeaeaaoaeueiiai aiia?aoa (nonoaaioth oi?io) e
aianonoaaioth, eiaaea ia?yaeo n iaei au?aaeaiiuie i?iyaeaieyie ni
noi?iiu iii?ii-aeaeaaoaeueiiai aiia?aoa ioia/aeenue aieaa au?aaeaiiua
i?eciaee ii?aaeaiey niaaeeieoaeueiie oeaie ae?oaeo i?aaiia e nenoai
(i?ieainu eeaiaiia, ?anoe?aiea aeoae ai?ou, iaeeiiiinoue e
e?iaioa/aieyi, i?eau/iua aueeaeuoe, iaoieiaey i?aaia c?aiey e ae?.).

Eco/aiea ianeaaenoaaiiinoe o 52 i?iaaiaeia e 72 ?iaenoaaiieeia I
noaiaie ?iaenoaa iicaieeei onoaiiaeoue aooiniiii-aeiieiaioiue oei
ianeaaeiaaiey aeia?iiaeeueiinoe n aunieei o?iaiai iaiao?aioiinoe
(0,7-0,8), eiaeaen niaoeeoe/aneiai aioo?enaiaeiiai iaeiieaiey (eiaeaen
Penrose) iieacae, /oi aeaiiue i?eciae n?aaee ?iaenoaaiieeia ano?a/aaony
a 2,25 ?aca /aua, /ai a iiioeyoeee. Aaiaaeiae/aneee aiaeec oaeaea
iieacae naiaeioth aa?aaaoeeth i?eciaea aaaaoi-ninoaeenoiai aeenaaeaina e
i?ieainia eeaiaiia o i?iaaiaeia e ianeaaeoaiuo ?iaenoaaiieeia. Iiene
aaiaoe/aneeo ia?ea?ia o aieueiuo AIN iieacae iaeaieueooth noaiaiue
annioeeaoeaiie nayce n?aaee aioeaaiia HLA A8, A35 e DR1.

Eco/aiea iaoaaieecia niaaeeieoaeueiie oeaie auyaeei iiauoaiea aeoeaiinoe
iacaioaiaeueiuo oa?iaioia (eieeaaaiaca, yeanoaca, ?<0,05) ia aieieienoua no?oeoo?u niaaeeieoaeueiie oeaie, /oi ia oiia iacia/eoaeueiiai oneeaiey eiaeaeoi?iie aeoeaiinoe (?>0,05) i?eaiaeeo e enoiuaieth eieeaaaia e
yeanoeia niaaeeieoaeueiie oeaie (oaaee/aiea ienei?ieeia, ?<0,05). E?iia oiai,eco/aiea aeneioii-uaei/iiai ?aaiiaaney iicaieeei onoaiiaeoue o aieueiuo aeeaeic n oi?ie?iaaieai eiiiainaoi?iiai iaoaaiee/aneiai aoeeaeica, /oi niinianoaiaaei enoiuaieth ioeiiieenaoa?eaeiuo e aaeeiauo eiiiiiaioia niaaeeieoaeueiie oeaie. Ia iniiaaiee auyaeaiiuo eeeie/aneeo, eaai?aoi?iuo e eino?oiaioaeueiuo i?eciaeia caaieaaaiey aia?aua i?aaeeiaeaiu aeeaaiinoe/aneea e?eoa?ee aeey AIN n o/?oii eo aieueoae eee iaiueoae niaoeeoe/iinoe e nenoaiiinoe ii?aaeaiey. I?aaeeiaeaiiue iaoiaaiaoe/aneee eiiieaen ea/aiey aeey aieueiuo AIN, aeeth/athuee a naay anei?aeiiaoth eeneioo e ?oiaeii iicaieee aeiaeoueny ei??aeoeee aeioeie/aneeo iieacaoaeae, a oaeaea iieiaeeoaeueiiai eeeie/aneiai yooaeoa. Aeey aieueiuo n i?aiaeaaeaieai aa?oaa?aeaee i?aaeeiaeai ea/aaiue eiiieaen ni/aoaiey aaceniie oa?aiee (?oiaeii+anei?aeiiaay eeneioa) n EOE, a aeey aieueiuo n i?aiaeaaeaieai na?aea/ii-ninoaeenouo i?iyaeaiee a eo?n ea/aiey ?aeiiaiaeoaony aeeth/aoue iaaieoioa?aieth, /oi iicaieeei aeiaeoueny iiauoaiea yooaeoa o aieueiuo n i?aiaeaaeaieai ?acee/iuo oi?i AIN. Eeth/aaua neiaa: Aeia?iiaeeueiue neiae?ii, ianeaaenoaaiiinoue, iaoaaieeci niaaeeieoaeueiie oeaie, eeeie/aneea i?iyaeaiey, e?eoa?ee aeeaaiinoeee, ea/aiea. IA?AEIE OIIAIEO IICIA*AIUe ANAe – aaaaoi-noaeeiia aeenoii?y AIN – a?ia?iia?eueiee neiae?ii AEA – aeaeo?iea?ae?ia?ao?y IIE – i?ieain i?o?aeueiiai eeaiaio IOE – i?ieain o?eeoni?aeaeueiiai eeaiaio

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