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Гігієнічні аспекти попередження синтезу канцерогенних N-нітрозамінів в повітряному середовищі і організмі людини: Автореф. дис… канд. біол. наук / Л

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OE?A?INUeEEE IAOEIAEE A?A??I?*IEE OeAIO?

NIAA?OEIAA EA?ENA NOAIAI?AIA

OAeE 615.277.3:504.75

A?A??I?*I? ANIAEOE IIIA?AAeAEAIIss NEIOACO EAIOeA?IAAIIEO N-I?O?ICAI?I?A
A IIA?O?ssIIIO NA?AAeIAEU? ? I?AAI?CI? ETHAeEIE

14.02.01-a?a??ia

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a-1999

Aeena?oaoe?y ? ?oeiienii

?iaioa aeeiiaia a Iaoeiai-aeine?aeiiio ?inoeooo? caaaeueii? oa
eiioiaeueii? a?a??ie ?i.I.I.Ia?c??aa IIC Oe?a?ie

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe *a?ie/aiei ?ai? Ieaen?eiae/, Iaoeiai-aeine?aeiee
?inoeooo ?i.I.I.Ia?c??aa IIC Oe?a?ie, caa?aeoaa/ eaai?aoi???th.

Io?oe?ei? iiiiaioe:

aeieoi? a?ieia?/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Aeoaai Ieaen?e
Ia?oai’yiiae/, Oe?a?inueeee iaoeiaee oeaio? iaaee/ii? aaiaoeee IIC
Oe?a?ie, caa?aeoaa/ eaai?aoi???th;

eaiaeeaeao a?ieia?/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Ieoaeeaiei
A?eoi? Ieoaeeiae/, ?inoeooo aenia?eiaioaeueii? iaoieia??, iieieia?? ?
?aae?ia?ieia?? ?i. ?.?. Eaaaoeueeiai IAI Oe?a?ie, caa?aeoaa/
eaai?aoi???th.

I?ia?aeia onoaiiaa – Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe
?i.I.E Ooieea, eaoaae?a a?a??ie oa aeieia?? ethaeeie, IIC Oe?a?ie,
i.Ee?a.

Caoeno a?aeaoaeaoueny “ 12 ” einoiiaaea 1999?. i 1000 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.604.01 i?e
Oe?a?inueeiio iaoeiaiio a?a??i?/iiio oeaio?? IIC Oe?a?ie
(253660,i.Ee?a-94,aoe.Iiioae?aiea,50)

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Oe?a?inueeiai
iaoeiaiai a?a??i?/iiai oeaio?o(i.Ee?a, aoe.Iiioae?aiea,50)

Aaoi?aoa?ao ?ic?neaiee “ 8 ” aeiaoiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,
Naeaciueia A.TH.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie

Na?aae o?i?/ieo ?a/iaei, ui caa?oaeiththoue iaaeieeoi? na?aaeiaeua,
iniaeeao o?eaiao aeeeeeathoue N-i?o?icai?ie (IA), ye? a?aecia/athoueny
aenieith eaioea?iaaiiith aeoeai?noth aeey eaai?aoi?ieo oaa?ei, a ca’yceo
c /ei ?icaeyaeathoueny I?aeia?iaeiei aaaionoaii c aea/aiiy ?aeo ye
iioaioe?ei? eaioea?iaaie aeey ethaeeie (Reed ?.?.,1996).

I?iaeaia IA a aoiinoa?iiio iia?o?? iio?aao? ?icaeyaeaiiy oaeeo ieoaiue
ye aiae?c oeueiai eeano niieoe, aeyaeaiiy ? eiio?iethaaiiy ooai?aiiy ?o
c iiia?aaeiee?a a iaaeieeoiueiio na?aaeiaeu? oa i?aai?ci? ethaeeie,
aecia/aiiy ianooaa?a ? caeiiii??iinoae ?iciianthaeaeaiiy, oeyoe
iiia?aaeaeaiiy aieeao ia ianaeaiiy. Ia?o ca ana oea noino?oueny oaeeo
i??i?eoaoieo niieoe eeano IA ye N-i?o?iciaeeiaoeeai?i (IAeIA) ?
N-i?o?iciae?aoeeai?i (IAeAA).

Iniaeeaith iciaeith, i?eoaiaiiith eaioea?iaaiiei IA, ? eaae?noue ?o
ooai?aiiy, caaaeyee i?ioeanai i?o?icoaaiiy, ia o?eueee a iaaeieeoiueiio
na?aaeiaeu? (aoiinoa?ia iia?o?y, a?oio, aiaea, i?iaeoeoe niiaeeaaiiy), a
? a aeeaiio i?aai?ci? (?oaai/ee A.E.,1990, Eeueieoeueeee A.I. oa
?i.,1993, Noaieaae/ A.A.,1996, Grisham M.B. et al.,1992, Magee
P.N.,1996). Oey ianoaaeia na?ae/eoue i?i oa, ui ?aaeueia ioe?iea
eaioea?iaaiiiai ?eceeo i?e ae?? i?o?iciniieoe iio?aao? aecia/aiiy
iioaioe?eii? iaaaciaee caa?oaeiaiiy iaaeieeoiueiai na?aaeiaeua ?o
iiia?aaeieeaie c iaeii/aniei o?aooaaiiyi ?ie? oeeo iiia?aaeiee?a a
aiaeiaaiiiio oa aeciaaiiiio neioac? eaioea?iaai?a. Aaoi?aie (Aoeueaoeyi
I.A. oa ?i.,1992, , Walters C.L. et al,1996, Bartsch H et al,1996, Ieenn
A.A. oa ?i.,1998) a?aecia/aii, ui IA, ye? aiaeiaaiii neioacothoueny,
i?eeiathoue o/anoue a ooai?aii? iooeei ??cieo eieae?caoe?e o oaa?ei.

?acii c oei ?ieue eiaeiiai c iiia?aaeiee?a a aiaeiaaiiiio neioac? IA
aea/aia iaaeinoaoiuei. Iac’yniaaieie caeeoathoueny, ia?aaeon?i,
e?euee?ni? aniaeoe ?o ooai?aiiy, aianie eiaeiiai c ieo a aiaeiaaiiee
neioac oa aeeeeeaiee ieie eaioea?iaaiiee aoaeo. A oie aea /an iio?aaa a
oe?e ?ioi?iaoe?? aaeeea, oiio ui oae? iiia?aaeieee IA, ye ieneaee acioo,
i?o?eoe (i?o?aoe) iao??th ? ai?ie ? i??i?eoaoieie caa?oaeithaa/aie
iaaeieeoiueiai na?aaeiaeua. Aea/aiiy iaoai?ci?a aca?iiae?? iiia?aaeiee?a
IA, ioe?iea oe?aeeeaiai aieeao ?o ia i?aai?ci oa eaioea?iaaiiiai ?eceeo
iia’ycaia c iaiao?aei?noth ae??oaiiy ?yaeo caaaeaiue oai?aoe/iiai,
iaoiaee/iiai ? i?aeoe/iiai iai?aaeaiiy.

An? oe? iaae??oaii? ieoaiiy, aaaeeea? ye aeey i?aeoeee nai?oa?ii?
neoaeae, oae ? aeey oai?aoe/ii? iaoee, iineoaoaaee i?aea?oioyi aeey
ieaioaaiiy aeaii? ?iaioe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Aeine?aeaeaiiy aeeiiaii a iaaeao aea?aeaaii? iaoeiai–oaoi?/ii?
i?ia?aie 1.1 “I?iaeaie aeieia?/ii? aaciaee Oe?a?ie” ? i?ia?aie “Ioi?iia
iaaeieeoiueiai na?aaeiaeua” IIC Oe?a?ie, iaoeiai-aeine?aeieo ?ia?o
IAe?CEA OIAOe IIC Oe?a?ie (? ae/? 79010958; ? a/? 8100498430; ? ae/?
01860012675; ? ae/? VA 01002664?; ? ae/? 0193V039176; ? ae/? VA
01002662?; ? ae/? 0180031127).

Iaoa ?iaioe: E?euee?nia ioe?iea iaaaciaee aeciaaiiiai oa aiaeiaaiiiai
neioaco IA (IAeIA ? IAeAA) c ?o iiia?aaeiee?a ? ?ic?iaea iaoiaee/ieo
i?aeoiae?a aei ?o aecia/aiiy.

Caaea/? aeine?aeaeaiiy:

1.?ic?iaea iaoiaeo aacio?iiaoia?ao?/iiai aecia/aiiy eaoeeo IA a
aoiinoa?iiio iia?o?? c aeei?enoaiiyi aia?aoo?e, aeinooiii? a?eueoino?
onoaiia, ye? eiio?ieththoue noai iaaeieeoiueiai na?aaeiaeua.

2.Anoaiiaeaiiy e?euee?nieo caeaaeiinoae aeciaaiiiai ? aiaeiaaiiiai
neioaco IA c ?o iiia?aaeiee?a a iiaeaeueieo, iaoo?ieo ?
aenia?eiaioaeueieo oiiaao.

3.?ic?iaea e?eoa??aeueii? oeaee ioe?iee i??i?eoaoiiai aeey aoiinoa?iiai
iia?o?y iiia?aaeieea IA – ae?ieneaeo acioo ca o/anoth eiai a aeciaaiiiio
neioac? oeeo eaioea?iaai?a.

4.Ioe?iea eaioea?iaaiii? iaaaciaee eiia?iiaaii? ae?? iiia?aaeiee?a –
ai?aeii??eio (AI), ae?ieneaeo acioo (NO2), i?o?eoo iao??th (II) a
aenia?eiaioaeueieo oiiaao.

5.Aecia/aiiy eaioea?iaaiiiai ?eceeo aeey ianaeaiiy ca ?aooiie
aiaeiaaiiiai neioaco IA c ?o iiia?aaeiee?a.

Iaoeiaa iiaecia ?iaioe

Aia?oa aeaia e?euee?nia ioe?iea oiia ? caeiiii??iinoae aeciaaiiiai ?
aiaeiaaiiiai neioaco IA c ?o iiia?aaeiee?a, aecia/aia i?ia?aeia ?ieue a
oeueiio i?ioean? i?o?icoth/iai eiiiiiaioa – ae?ieneaeo acioo. Iieacaia
eaioea?iaaiia iaaaciaea eiia?iiaaii? ae?? iiia?aaeiee?a IA (AI, II, NO2)
ia i?aai?ci, ui i?iyaey?oueny a ?iaeoeoaaii? ceiye?nieo oa aeia?iye?nieo
iiaiooai?aiue.

Aeyaeaii noaa?eueiee ca’ycie a aoiinoa?iiio iia?o?? i?iieneiaiai i?noa
i??i?eoaoieo IA – IAeIA, IAeAA ? ?o iiia?aaeieea NO2, aeaia ioe?iea
iaaaciaee aeey caei?ia’y ianaeaiiy.

Oai?aoe/ia cia/aiiy ?iaioe iieyaa? a:

– onoaiiaeaii? caeiiii??iinoae aeciaaiiiai ? aiaeiaaiiiai neioaco IA a
caeaaeiino? a?ae ??aiy ai?noo ?o iiia?aaeiee?a;

– iaa?oiooaaii? i?iaiinoe/iiai e?eoa??th ioe?iee iiaeeeaino? aeciaaiiiai
neioaco oeeo niieoe a aoiinoa?? ia iniia? ii??aiyiiy ??cieo
ni?aa?aeiioaiue iiia?aaeiee?a IA oa a?aeiia?aeieo ?i ??ai?a IAeIA ?
IAeAA.

– aecia/aii? e?euee?nieo iieaciee?a eaioea?iaaiiiai ?eceeo eiia?iiaaii?
ae?? iiia?aaeiee?a IA a i?aai?ci? aenia?eiaioaeueieo oaa?ei.

I?aeoe/ia cia/aiiy ?iaioe iieyaa? a:

– ?ic?iaoe? niiniao oeiaethaaiiy IA ia niaoe?aeueii ia?iaeaia aeoeaiaaia
aoa?eey;

– ?ic?iaoe? iaoiaeo aacio?iiaoia?ao?/iiai aiae?co i?ia iia?o?yiiai
na?aaeiaeua aeey ?aeaioeo?eaoe?? i?e?iaeii?oie IAeIA ? IAeAA c
aeei?enoaiiyi aeinoaoiuei /ooeeai? oa aeinooiii? aeey onoaiia, ye?
eiio?ieththoue noai iaaeieeoiueiai na?aaeiaeua, aia?aoo?e;

– ai?iaaoe?? a?aie/ii aeiionoeii? eiioeaio?aoe?? (AAeE) ae?ieneaeo acioo
ca eiai aieeaii ia aeciaaiiee oa aiaeiaaiiee neioac i?o?icai?i?a;

– ?ic?iaoe? e?eoa??aeueii? oeaee aeey i?iaiicoaaiiy ?eceeo cae?eniaiiy
aeciaaiiiai oa aiaeiaaiiiai neioaco IA a caeaaeiino? a?ae eiioeaio?aoe?e
ae?ieneaeo acioo.

Ai?iaaaeaeaiiy a i?aeoeeo

Io?eiai? iaoa??aee aeei?enoaii a i?ioean? i?aeaioiaee ianooiieo
iaoa??ae?a:

1. Niinia ii?aaeaeaiey ieo?iciaeeiaoeeaieia e aeeiaoeeaieia a aicaeooa :
Aaoi?neia naeaeaoaeuenoai ? 938149 io 23 oaa?aey 1982a.-I,1982.

2. Iaoiaee/aneea i?eaiu ioai?a i?ia aoiinoa?iiai aicaeooa e ii?aaeaeaiea
a ieo ieo?iciaeeiaoeeaieia e aai i?aaeoanoaaiieeia /Eioi?iaoeeiiiia
ienueii.-Eeaa:IC ONN?,1981.

3. E?eoa?ee iianiinoe eaioea?iaaiiiai neioaca ieo?icaieiia:
Eioi?iaoeeiiiia ienueii.-Eeaa:IC ONN?,1984.

4. I?eniiniaeaiea aeey i?aaeioa?auaiey oioioeie/aneiai ?aceiaeaiey
ieo?icaieiia a i?iaa (niinia ioai?a) /?aoe.i?aaeeiaeaiea.

5. Iaoiaee/aneea ?aeiiaiaeaoeee ii ii?aaeaeaieth N-ieo?iciaeeiaoee- e
N-ieo?iciaeeyoeeaieiia a aicaeooa /IEEIEA,IC ONN?.-Eeaa,1985.-12n.

6. Iaoiaeeea ioai?a i?ia aoiinoa?iiai aicaeooa e ii?aaeaeaiea a ieo
ieo?iciaeeiaoeeaieia /Eioi?i.ienueii.-Eeaa:IC ONN?,1986.

7. Niinia ioai?a i?ia aoiinoa?iiai aicaeooa e ii?aaeaeaiea a ieo eaoo/eo
N-ieo?icaieiia /?aoe.i?aaeeiaeaiea.-Oaeinoiaa?aiea N581 io 21.06.87a.

8. A?aie/ii aeiionoeia eiioeaio?aoe?y i?o?iciaeeiaoeeai?io a
aoiinoa?iiio iia?o?? ianaeaieo i?noeue (I?aaeaeueii aeiionoeiua
eiioeaio?aoeee /IAeE/ e i?eaioe?iai/ii aaciianiua o?iaie aicaeaenoaey
caa?yciythueo aauanoa /IAOA/ a aoiinoa?iii aicaeooa ianaeaiiuo
iano.-Aeiiaoee,1998.-N.44).

9. Iiaeeo?eaoe?y iaoiaeo aecia/aiiy eaioea?iaaiieo i?o?icai?i?a –IAeIA ?
IAeAA a a?ieia?/iiio iaoa??ae? /Eioi?iaoeeiiiia ienueii.-Eeaa,1996.

10. Ia?ae?e ?a/iaei, i?iaeoeo?a, ae?iaie/eo i?ioean?a, iiaooiaeo oa
i?e?iaeieo oaeoi??a, eaioea?iaaiieo aeey ethaeeie: Aea?aeaaiee
a?a??i?/iee ii?iaoea.-Ee?a: I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie,
Eii?oao c ieoaiue a?a??i?/iiai ?aaeaiaiooaaiiy,1997.-14n.

Iieiaeaiiy, ye? aeiinyoueny ia caoeno:

1. ?ic?iaea iaoiaeo aacio?iiaoia?ao?/iiai aecia/aiiy IA (IAeIA ? IAeAA)
a iia?o?yiiio na?aaeiaeu?.

2. Anoaiiaeaiiy iniiaieo caeiiii??iinoae aeciaaiiiai neioaco IA c ?o
iiia?aaeiee?a, ye? iniiaai? ia aea/aii? ni?aa?aeiioaiue i?o?icoth/iai
eiiiiiaioa – NO2 oa IAeIA ? IAeAA) a iiaeaeueieo oiiaao oa ia iniia?
iii?oi?eiaiaeo niinoa?aaeaiue.

3. Aenia?eiaioaeueia anoaiiaeaiiy aeici-/aniaeo oa aeici-aoaeoieo
caeaaeiinoae iiyae IA o aioo??oi?o i?aaiao i?aeaeine?aeieo oaa?ei ?
?icaeoeo a ieo iiaiooai?aiue aiane?aeie aiaeiaaiiiai neioaco
eaioea?iaai?a c ?o iiia?aaeiee?a.

Iniaenoee aianie a ?ic?iaeo iniiaieo iieiaeaiue aeena?oaoe??

Aeena?oaio naiino?eii ?ic?iaea oa nieaioaaa eiiieaen iiaeaeueieo,
iaoo?ieo ? aenia?eiaioaeueieo aeine?aeaeaiue, iei i?iaaaeaii a?eueo ye
85% o?ceei-o?i?/ieo oa aenia?eiaioaeueii-iieieia?/ieo aeine?ae?a,
iiai?noth aeeiiaii iaoaiaoe/io ia?iaeo oa ioe?ieo iaea?aeaieo
?acoeueoao?a. I?e ioi?ieaii? cayaee ia aeiao?ae iniaenoee aianie aaoi?a
40%.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

Iniiai? iieiaeaiiy ?iaioe aeiiia?aeaeenue ia Ananithcieo neiiic?oiao
“Eaioea?iaaiiua –ieo?iciniaaeeiaiey e eo i?aaeoanoaaiieee – ia?aciaaiea
e ii?aaeaeaiea a ie?oaeathuae n?aaea” (Oaeeeii,1981,1984,1987), ia O
c’?cae? a?a??i?no?a (Ee?a,1981), ia 1O c’?cae? a?a??i?no?a Oe?a?inueei?
?N? (Euea?a,1886), ia I?aeia?iaei?e iaoeiai-oaoi?/i?e eiioa?aioe??
“Yeieiaey oeie/aneeo i?iecaiaenoa” (Naaa?iaeiiaoee,1994), ia iaoeiaeo
eiioa?aioe?yo “A?a??ia iaaeieeoiueiai na?aaeiaeua”
(Ee?a,1988,1989,1991,1995), ia ?O c’?cae? iieieia?a Oe?a?ie
(A?iieoey,1995), ia ??? oa ?V I?aeia?iaeieo neiiic?oiao ii caa?oaeiaiith
aeiae?eey (Aa?oaaa,1996,1998), ia Anaoe?a?inuee?e iaoeiai-iaoiaee/i?e
eiioa?aioe?? ”Aeieia?y oa ?iaeaia??y” (Aei?i?iaeca?aeeinuee,1998), ia
iaoeiai-i?aeoe/i?e eiioa?aioe?? “I?iaeaie aeieia?/ii? oa iaaee/ii?
aaiaoeee ? ee?i?/ii? ?ioiieia??” (Ee?a,1999).

Ioae?eaoe??

?acoeueoaoe aeena?oaoe?? iioae?eiaaii a 12 noaooyo a iaoeiaeo aeo?iaeao
oa ca??ieeao iaoeiaeo i?aoeue, o 17 iaoa??aeao oa oacao iaoeiaeo
neiiic?oi?a, c’?cae?a, eiia?an?a ? eiioa?aioe?e, io?eiaii aaoi?nueea
na?aeioeoai ia aeiao?ae.

Ianya oa no?oeoo?a ?iaioe

Aeena?oaoe?y aeeeaaeaia ia 175 noi??ieao iaoeiiieniiai oaenoo oa
neeaaea?oueny ?c anooio, 5 ?icae?e?a, aeniiae?a, nieneo aeei?enoaieo
e?oa?aoo?ieo aeaea?ae (221 iaeiaioaaiiy, c yeeo 99 a?o/eciyieo oa e?a?i
NIAe ? 122 ?iicaiieo). ?iaioa ?ethno?iaaia 24 oaaeeoeyie, 14 ?enoieaie.

INIIAIEE CI?NO ?IAIOE

Ia’?eoe, iaoiaee oa iaoiaeieia?y aeine?aeaeaiue

Aeoiaey/e c iaoe aeaii? ?iaioe oa ?? caaaeaiue, aea/aiiy caa?oaeiaiiy
aoiinoa?iiai iia?o?y eaioea?iaaiieie IA (IAeIA ? IAeAA) oa ?o
iiia?aaeieeaie (NO2, aeeiaoeeai?iii ? ae?aoeeai?iii) i?iaiaeeeinue a
i.Ee?a?, a ?aeii? ?ici?uaiiy i?aei?e?inoa o?i?/ii? i?iieneiaino?, OAN,
aaoiiaa?no?aeae ia 2 ioieoao iii?oi?eiaiaeo niinoa?aaeaiue,
i?aai?ciaaieo ia aac? noaoe?iia?ieo iino?a. I?iae iia?o?y a?aeae?aeenue
ia iaioa 20 aei?a ia i?nyoeue i?ioyaii ?ieo. I?aai?caoe?y ? i?iaaaeaiiy
aeine?aeaeaiue aoiinoa?iiai iia?o?y cae?enithaaeanue c o?aooaaiiyi
iaoiaee/ieo ?aeiiaiaeaoe?e ? i?eioeei?a, ui ?niothoue a eiioiaeuei?e
a?a??i? (?oeiaiaenoai ii eiiopieth caapyciaiey aoiinoapu.-I., 1991).

Aiae?c iia?o?y ia ai?no NO2 cae?enithaaany caaaeueiii?eeiyoei iaoiaeii c
aeei?enoaiiyi ?aaeoeao A?ena. Oeiaethaaiiy oa e?euee?nia aecia/aiiy
eaioea?iaaiieo IA (IAeIA ? IAeAA) ? a?aeiia?aeieo ai?i?a a iia?o?yiiio
na?aaeiaeu? i?iaiaeeeinue ca iaoiaeeeith, ?ic?iaeaiith a iaaeao aeaii?
?iaioe.

A iiaeaeueieo aeine?aeao aeey aeyaeaiiy iiaeeeaino? aeciaaiiiai neioaco
IA c iiia?aaeiee?a (NO2, aeeiaoeeai?io ? ae?aoeeai?io)
aeei?enoiaoaaeenue eaia?e ia’?iii 200 e, a yeeo noai?thaaeenue o? /e
?io? eiioeaio?aoe?? NO2, a ai?ie ciaoiaeeeenue a eaia?? a niaoe?aeueieo
a?aee?eoeo ?ieinoyo. A eaia?ao iino?eii i?aeo?eioaaeanue iaaia
eiioeaio?aoe?y oeeo ?a/iaei.

Aeey i?yiiai iiaeoaapaeaeaiiy aiaeiaaiiiai neioaco eaioeapiaaiieo HA in
vivo ipiaiaeeeenue oiceei-oiii/ii aeineiaeaeaiiy aiinoo oeeo pa/iaei o
aioopioiio ipaaiao aeniapeiaioaeueieo oaapei: ia/iioei, eaaaiyo oa
iepeao. Ipe oeueiio canoiniaoaaeanue iiaeeo?eiaaia iaie iaoiaeeea
T.Maki, 1980. A aeine?ae? aoei aeei?enoaii 150 a?eeo aacii?iaeieo uo??a,
?icae?eaieo ia o?e a?oie (aea? c ieo iaea?aeoaaee iiia?aaeieee IA, iaeia
a?oia – ?ioaeoiee eiio?ieue). ?aeaioeo?eaoe?y IA cae?enithaaeanue aei
ii/aoeo aaaaeaiiy iiia?aaeiee?a, ia 15 ? 30 aeiao ?o ae??, a oaeiae
/a?ac 30 aei?a i?ney i?eieiaiiy cao?aaee oaa?ei.

Opiii/iee aeineiae, nipyiiaaiee ia aea/aiiy eieueeinieo iapaiaopia
aiaeiaaiiiai neioaco iiopicaiiiia oa c’ynoaaiiy iaoaiiciia
eaioeapiaaiii? aei? ?o iiiapaaeieeia, aeeiioaaany ia 350 aieeo
aaciipiaeieo uopao-naieao. Anueiai aoei 6 apoi oaapei, ui ciaoiaeeeenue
iiae aieeaii aeiieneaeo acioo, aiiaeiiipeio oa iiopeoo iaopith, ? iaeia
a?oia ?ioaeoiiai eiio?ieth, ii 50 oaa?ei o eiaei?e.

Napaaeii eiioeaiopaoei? NO2 a eaiapao noaiiaeee aiaeiiaiaeii 0.04 – 0.07
ia/i3, 0.45-0.46 ia/i3, 0.84 – 0.90 ia/i3.

Iaeii/anii c iiaaeyoeiyie NO2 oinoue aeiia ia oeaeaeaiue uopai aeaaaee
AI c ?aeath oa HH c aiaeith. Uiaeaiia aeica noaiiaeea aeey AI – 30, aeey
HH – 20 ia/ea iane oiea oaapei. Aanue iapiiae caopaaee iiaeaeineiaeieo
uopia iiia?aaeieeaie HA opeaaa 10 eaeaiaeapieo iinyoeia, a iaaeyae ca
oaapeiaie, yei aoee iiaeaeaii aei? NI2, aiiaeiiipeio oa iiopeoo iaopith,
ipiaeiaaeoaaany ipioyaii anueiai ?o aeeooy aei ipepiaeii? niapoi. Iiney
caaeaaei ani iiaeaeineiaeii oaapeie iiaeeyaaee picoeio oa
iaoiiipoieiai/iiio aeineiaeaeaiith, anueiai aoei i?aeaioiaeaii ?
iiepineiii/ii aeineiaeaeaii aeecueei 35000 ainoieiai/ieo ipaiapaoia. Ipe
oeueiio aoee aeeipenoaii caaaeueiii?eeiyo? iaoiaeeee. Ii?oieia?/i?
aeine?aeaeaiiy aeeiioaaeenue noi?nii ?c no.i.n., e.i.i. Aaeaiei I.A.

O 120 oaapei aeeo/aii aioopioii ipaaie aeey aecia/aiiy aiinoo a ieo
eaioeapiaaiieo iiopicaiiiia, ipiaaaeaii aeecueei 50 oiceei-oiii/ieo
aeiipia. Ipe eiiopiei ca aiinoii aeiieneaeo acioo a iiaiopi eaiap
aiaeiapaii oa ipiaiaeiciaaii aeecueei 500 ipia iiaiopy.

Noaoenoe/io iapiaeo iaoapiaeia iiaeainopiai i opiii/iiai aeineiaeia
ipiaaaeaii c aeeipenoaiiyi t-epeoapith No’thaeaioa oa epeoapith Iipniia
– 2 (Oo?onia A.N., Ia?oaiia TH.Ae.,1986, Eaeei A.O.,1990).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

?ic?iaea iaoiaeo aecia/aiiy IAeIA ? IAeAA a iia?o?yiiio na?aaeiaeu?

C oe??th iaoith aea/aeenue ieoaiiy, iia’ycai? c oiiaaie a?aeai?o i?ia
iia?o?y, aeae?eaiiyi oa eiioeaio?oaaiiyi i?e?iaeii?oie oeeo niieoe,
aecia/aiiyi iioeiaeueieo oiia aacio?iiaoia?ao?/iiai aiae?co oa
ian-niaeo?iiao?e/ieo aeine?aeaeaiue.

?ic?iaeaiee iaoiae aiae?co IAeIA ? IAeAA aeeth/a? ianooii? aoaie:

1. Oeiaethaaiiy eaoeeo i?o?icai?i?a (IAeIA ? IAeAA) ia oaa?aeee ni?aaio
(o?oaea-oeiaethaa/, caiiaiaia niaoe?aeueii ia?iaeaiei aeoeaiaaiei
aoa?eeyi) i?e iii?oi?eiaiaeo aeine?aeaeaiiyo aai a ??aeea eoaeia
na?aaeiaeua (0,1N ?ic/ei EII) – i?e ei?ioei/anieo a?aeai?ao i?ia.

2. Aeani?aoe?y IAeIA ? IAeAA ae?aoeeiaei ao??ii c oaa?aeiai ni?aaioo aai
aeiaoooy ? aecia/aiiy ?o iaoiaeii ??aiiaaaeii? ia?iai? oace c ??aeeiai
iiaeeia/a.

3. Eiioeaio?oaaiiy aeno?aeoo aei ia’?io 1 ie.

4. Aacio?iiaoia?ao?/iee aiae?c neiioeaio?iaaii? i?iae.

5. ?ic?aooiie eiioeaio?aoe?e.

Oiiae aacio?iiaoia?ao?/iiai aiae?co: aaciaee o?iiaoia?ao c
iieoiaiaai-?ii?caoe?eiei aeaoaeoi?ii, eieiiea neeyia aai eaooiia (320ni
o 3 ii), iaiiaiaia 10% PEG-4000 ia o?iiaoii? N-AW-HMDS (0,16-0,20 ii),
aeo?aoe aaco-iin?y aae?th – 30 ie/oa., oaiia?aoo?a eieiiee – 140iN,
oaiia?aoo?a aeia?ieea – 200iN, oaiia?aoo?a aeaoaeoi?a – 200iN.

*ooeea?noue iaoiaeo neeaaea? 0,05 iea a i?ia?. Noia?ia iioeaea ia
ia?aaeuo? 25%. ?iaioa ii aeaiiio ?icae?eo cae?enithaaeanue noi?nii c
e.o.-i.i. Eeoae/aiei I.I.

E?euee?ni? aniaeoe aeciaaiiiai neioaco eaioea?iaaiieo N-i?o?icai?i?a ?c
?o iiia?aaeiee?a

Ae??oaiiy ieoaiiy uiaei iiaeeeaino? aeciaaiiiai neioaco IA a ?iaio?
cae?enithaaeinue o aeaa aoaie: oeyoii iiaeaethaaiiy i?ioeano a
eaia?aeueieo oiiaao, a oaeiae i?iaaaeaiiy iaoo?ieo aeine?aeaeaiue. I?e
iiaeaethaaii? i?ioeano a eaia?ao noai?thaaeenue noae? eiioeaio?aoe??
aeeiaoeeai?io oa ae?aoeeai?io – 0,1600,04 ia/i3 oa 0,1720,05 ia/i3
a?aeiia?aeii. Caiaeii nthaee iiaeaaaee ??ci? eiioeaio?aoe?? NO2 – a?ae
0,088 ia/ i3 aei 1,660 ia/i3.

Aaaeeeai i?aee?aneeoe, ui cacia/aiee ae?aiacii eiioeaio?aoe?e ai?i?a ?
ae?ieneaeo acioo ioiiethaaa oae?, ui iathoue i?noea a ?aaeueieo oiiaao
ye a aoiinoa?iiio iia?o?? ianaeaieo i?noeue, oae ? a iia?o?? ae?iaie/eo
i?ei?uaiue. A ?acoeueoao? aoei iieacaii, ui i?e noai?aii? iia?o?yii?
noi?o? iiia?aaeiee?a IA inoaii? ?aeaioeo?eoaaeenue aaea /a?ac 15 oaeeei.
I?e oeueiio ?o ??aaiue /?oei i?aeii?yaeeiao?oueny aeici-aoaeoi?e
caeaaeiino?, a i?ia?aeio ?ieue ooo a?ae?a?a? i?o?icoth/ee eiiiiiaio –
NO2. sseui i?e i?aeo?eioaaii? NO2 a iaaeao AAeE aeey aoiinoa?iiai
iia?o?y ianaeaieo i?noeue IA ia aeyaeyeenue, oi ia ??ai? 2,0 –2,5
iaeneiaeueii ?aciaeo AAeE ? aeua /?oei i?inoaaeoaaeanue iayai?noue IA, a
eiao?oe??io ei?aeyoe?? i?ae ieie oa iiia?aaeieeaie aei??aithaaa
0,71-0,91.

A?ao?/ii oeae i?ioean a?aeia?aaeaii ia ?en.1 ? 2, c yeeo aeaeii, ui
caeaaeiino? i?ae eiioeaio?aoe??th aeciaaiii ooai?aieo IAeIA ? IAeAA oa
??aiyie ?o iiia?aaeieea – ae?ieneaeo acioo iathoue aeaeyae aeniiiaioe.

Caeiiii??iino? aeciaaiiiai ooai?aiiy N-i?o?icai?i?a c ?o iiia?aaeiee?a a
oiiaao iiaeaeueiiai aenia?eiaioo aeia?a iienothoueny aeniiiaioe?aeueieie
??aiyiiyie 1 ? 2, ye? a?aeaeaathoue iniaeeaino? oeueiai i?ioeano.

Aeey IAeIA:

y = 0,5 [(1 – exp (-1,025 x)][1 – exp (-0,024t)],
(1)

aeey IAeAA:

y = 1,5 [(1 – exp (-0,94 x)][1 – exp (-0,023t)],
(2)

aea

o – eiioeaio?aoe?y ooai?aiiai a iiaeaeueieo oiiaao IAeIA aai IAeAA;

x – eiioeaio?aoe?y iiia?aaeieea N-i?o?icai?i?a – ae?ieneaeo acioo;

t – /an a?ae ii/aoeo aenia?eiaioo.

Ioaea, io?eiai? ?acoeueoaoe iiaeaeueieo aeine?ae?a aeacothoue ia ??aaiue
NO2 (0,200 ia/i3), i?e aeinyaiaii? yeiai a?aeaoaa?oueny neioac IA.
A?eueo iecuee? eiioeaio?aoe?? NO2, cie?aia ia ??ai? AAeE, oaeiai aoaeoo
ia aeeeeeathoue.

Aeoiaey/e c oeueiai, aaaeeeai aecia/eoe iiaeeea?noue ia?aa?ao oaeeo
?aaeoe?? a ?aaeueieo oiiaao. Aeine?aeaeaiiy oeueiai yaeua ia oa?eoi???
i?noa cae?enithaaeinue ia aeaio noaoe?iia?ieo ioieoao oeyoii
iii?oi?eiaiaeo niinoa?aaeaiue i?ioyaii ??/iiai oeeeeo. Io?eiai? aeai?
cana?ae/othoue iayai?noue a aoiinoa?iiio iia?o?? IAeIA ? IAeAA. I?e
oeueiio a?ao?/ia cia?aaeaiiy ?aaeueiiai caa?oaeiaiiy aeaco? ia cia/io
aeeiai?/i?noue eiioeaio?aoe?e i?ioyaii ?ieo, aea oe?eaaei ? oaeo
?aeaioe/iino? oiaeo e?eaeo na?aaeiueii?ny/ieo eiioeaio?aoe?e IAeIA,
IAeAA oa NO2 i?ioyaii ?ieo (?en.3). Aeey oeeo niieoe oa?aeoa?iei ?
i?i?iaeueiee ?o ??aaiue a ceiiaee ia??iae, a iaeneiaeueiee – a e?oi? oa
in?ii? i?nyoe?. I?e oeueiio ca?a?no?iaaii aeaa iaeneioie eiioeaio?aoe?e:
a eeii?-na?ii? oa aeiaoi?-eenoiiaae?. ?o iiyaa iia’ycaia a??ia?aeii c
ia??iaeii i?aeaeuaiiai oeueo?ao?ieaoiaiai ii?ii?iaiiy a e?oi?e oa
in?ii?e naciie, yea ? ioneiaei iaoai?ciii oioio?i?/ieo ?aaeoe?e a
iia?o??, ui noeioeth? ooai?aiiy IA. I?iaaaeaiee iaoaiaoe/iee aiae?c
io?eiaieo ?acoeueoao?a iieacaa iayai?noue ei?aeyoe?eiiai ca’yceo i?ae
ai?noii oeeo niieoe (r = 0,81-0,86).

Ona neacaia aeicaiey? iai eiinoaooaaoe oaeo aeciaaiiiai ooai?aiiy IA c
?o iiia?aaeiee?a a ?aaeueieo oiiaao, ui neeaaea? iaaio eaioea?iaaiio
iaaaciaeo aeey ianaeaiiy. A?aoiaoth/e noaa?euei?noue caa?oaeiaiiy
aoiinoa?e ae?ieneaeii acioo oa eaaaiaaee oeyo eiai ae?? ia i?aai?ci,
eaaei ia?aaeaa/eoe aieeao NO2 eiai ia aiaeiaaiiee i?ioean.

E?euee?ni? aniaeoe aiaeiaaiiiai neioaco eaioea?iaaiieo N-i?o?icai?i?a

?iaeeeaoe?y aiaeiaaiiiai neioaco aiane?aeie aaaaeaiiy iiia?aaeiee?a oa
ioe?iea eiai iaaaciaee a i?aeaino?iio aeine?ae? i?iaiaeeeanue oeyoii
o?ceei – o?i?/iiai aeyaeaiiy ai?noo IA (IAeIA, IAeAA) a ??ci? oa?i?ie
aenia?eiaioo aaciina?aaeiuei a i?aaiao – ia/?ioe?, eaaaiyo, ie?eao.
?acoeueoaoe iieacaee, ui a i?aaiao oaa?ei eiio?ieueii? a?oie, ye? ia
i?aeaeaaaeenue ae?? ?a/iaei, IAeIA a i?aai?ci? ia aeyaeyany,
i?enooi?noue IAeAA ca?a?no?iaaii ye ne?aee eeoa a ie?aieo i?iaao
ia/?iee. O uo??a, ye? io?eioaaee iiia?aaeieee IA (NO2, AI, II), i?ae /an
aaaaeaiiy anoaiiaeaii iayai?noue IAeIA a ia/?ioe?, eaaaiyo, ie?eao a
e?eueeinoyo 0,0071 iea/a,0,0080 iea/a ? 0,0125 iea/a a?aeiia?aeii, ye?
aoee aeaui aeueie, i?ae a?aeiia?aei? e?eueeino? IAeAA – 0,0035 iea/a;
0,0040 iea/a oa 0,0062 iea/a a oeeo aea i?aaiao. I?e aeine?aeaeaii?
ai?noo IA a i?aaiao /a?ac i?nyoeue i?ney cae?i/aiiy aaaaeaiiy
iiia?aaeiee?a aeine?aeaeoaai? niieoee ia aoei ?aeaioeo?eiaaii.

Aea/aiiy eaioea?iaaiii? iaaaciaee aaaaeaiiy iiia?aaeiee?a N-i?o?icai?i?a
a o?ii?/iiio aenia?eiaio? i?iaiaeeeinue ca e?euee?nieie (/anoioa, /an,
iiiaeeii?noue ?icaeoeo) ? ye?nieie (eieae?caoe?y, a?noieia?/ia no?oeoo?a
? aaiac, ceiye?ni?noue, iaoanoacoaaiiy) iieacieeaie ?icaeoeo
iooeei.(oaae.1.).

Iaoiii?oieia?/i? aeine?aeaeaiiy i?aai?a ? oeaiei uo??a cana?ae/eee i?i
?icaeoie iooeei ??cii? eieae?caoe?? o oaa?ei an?o a?oi, ii/eiath/e c
483-ai aeiy a?ae ii/aoeo aenia?eiaioo.

O ?ioaeoieo eiio?ieueieo uo??a 1 a?oie, a oaeiae oaa?ei 2 a?oie, ye?
io?eioaaee ?iaaeyoe?? ae?ieneaeo acioo a eiioeaio?aoe?? ia ??ai? 1 AAeE,
/anoioa iiaiooai?aiue aoea iaeiaioith ? neeaaeaea a?aeiia?aeii 15,8% oa
15,0%. O uo??a, ye? iaea?aeoaaee ai?aeii??ei, a oaeiae ??ci?
eiioeaio?aoe?? ae?ieneaeo acioo noi?nii c ?ioeie iiia?aaeieeaie
i?o?icai?i?a (AI, II), iooeeie ?icaeaaeenue /ano?oa, i?ae a eiio?ieueieo
a?oiao ? caeaaeaee a?ae eiioeaio?aoe?? ae?ieneaeo acioo oa neeaaeo
ae?th/iai eiiieaeno iiia?aaeiee?a.

Oae, i?e aaaaeaii? eeoa ai?aeii??eio (3 a?oia) iooeeie ca?a?no?iaaii o
16,6% oaa?ei, i?e aaaaeaii? ai?aeii??eio noi?nii c ?iaaeyoe??th
ae?ieneaeo acioo ia ??ai? AAeE (4 a?oia) – o 17,2%, ui nooo?ai ia
a?ae??ciy?oueny a?ae eiio?ieueieo oaa?ei.

A oie aea /an eiia?iiaaia aaaaeaiiy ai?aeii??eio c ae?ieneaeii acioo ia
??ai? 10 AAeE (5 a?oia) oa 20 AAeE (6 a?oia), a oaeiae ae?ieneaeo acioo
(20 AAeE) ? i?o?eoo iao??th (7 a?oia) i?ecaaei aei ?icaeoeo iooeei
a?aeiia?aeii o 48,0%; 57,1% ? 60,0%, ui aeinoia??ii aeua, i?ae a
?ioaeoiiio eiio?ie? (?

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