OA?E?ANUeEEE AeA?AEAAIEE OI?AA?NEOAO

Oaaeioa Ieaia Ieoaee?aia

OAeE 575.616

AAIAOE*IA AeINE?AeAEAIIss INI??ACO

03.00.15 – Aaiaoeea

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Oa?e?a – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio oi?aa?neoao?.

Iaoeiaee ea??aiee:

aeieoi? a?ieia?/ieo iaoe, aeioeaio

Ao?aiaioiaa Ethaia Ieaen??aia,

i?ioani? eaoaae?e aaiaoeee oa oeeoieia??

Oa?e?anueeiai aea?aeaaiiai oi?aa?neoaoo

Io?oe?eie iiiiaioe:

1. Aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeueiaa Ieueaa Ieeiea?aia,
caa?aeoth/a eaoaae?ith i?iiaaeaaoeee aioo??oieo oai?ia N1Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

2. Eaiaeeaeao a?ieia?/ieo iaoe Ooaiaeaeue Na?oeaia Aiaoie??aia, iaoeiaee
ni?a?ia?oiee a?aeae?eo iaoieia?? i?aeoeoieiai? caeice Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo oa?iaeioa?ai?? aiaeie?eiieo
caoai?thaaiue.

I?ia?aeia onoaiiaa:

Oe?a?inueeee iaoeiaee a?a??i?/iee oeaio?, eaai?aoi??y aaiaoe/iiai
iii?oi?eiao, i. Ee?a.

Caoeno a?aeaoaeaoueny “16” a?oaeiy 1998 ?. i 13.30 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E64.051.18 Oa?e?anueeiai aea?aeaaiiai
oi?aa?neoaoo ca aae?anith: 310077, i.Oa?e?a, i. Naiaiaee, 4, aoae. 3-15.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai oi?aa?neoaoo ca aae?anith: 310077, i.Oa?e?a, i. Naiaiaee,
4.

Aaoi?aoa?ao ?ic?neaiee “10 ” eenoiiaaea 1998 ?.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee
A.A.Iae?aniaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aeooaeuei?noue aaiaoe/ieo aeine?aeaeaiue ini??aco
aecia/a?oueny eiai aenieith ?iciianthaeaeaii?noth, /anoei o?aaeaiiyi
ethaeae i?aoeacaeaoiiai a?eo, aenieith ?iaae?ae?caoe?ath oai?eo ?
iaiao?aei?noth aeyaeaiiy a?oie ?eceeo aeey iaaeeei-aaiaoe/iiai i?iaiico.
Aeey iiyniaiiy ee?i?/ii? aaoa?iaaiiino? ini??aco i?iiiioaaeeny ??ci?
iiaeae? oniaaeeoaaiiy caoai?thaaiiy (Ii?aeiaoeaa, 1991, Abele, 1963).
Anoaiiaeaiee oaeo ioeueoeoaeoi??aeueii? i?e?iaee ini??aco i?e o/ano?
aeae?eueeio aaiaoe/ieo ? na?aaeiaeuieo oaeoi??a caeeoa? iayniei
aaiaoe/io aca?iiae?th i?ae ie?aieie ee?i?/ieie oi?iaie ini??aco, oaeeie,
ye cae/aeiee, a?o?iiaoe/iee ? ?io? oi?ie caoai?thaaiiy. Iaiao?aeii
a?aecia/eoe, ui ?iaioe ii aaiaoeoe? ini??aco a iniiaiiio noinoaaeenue
caoai?thaaiiy a oe?eiio aac o?aooaaiiy eiai ee?i?/ieo oi?i. I?iaiaeeany
o?eueee eeei?ei-aaiaoe/iee aiae?c aeaio oi?i ini??aco: cae/aeii? ?
a?o?iiaoe/ii?. ??cieoe? a oa?aeoa?? oniaaeeoaaiiy i?ae ieie ia aeyaeaii
(Ea?aaeiia, 1983). Oea aeaco? ia iaiao?aei?noue aeine?aeaeaiiy
aaiaoe/ieo aca?iia?aeiinei ??cieo ee?i?/ieo oi?i ini??aco,
ni?aa?aeiioaiiy aieeao niaaeeiaeo ? na?aaeiaeuieo /eiiee?a ia ?icaeoie
ini??aco, aieeao iiioeyoe?eieo i?ioean?a ia ?iciianthaeaeaiiy ini??aco.
Aea/aiiy iiioeyoe?eii? /anoioe ini??aco, iniaeeainoae eiai aaia?ao?/iiai
?iciianthaeaeaiiy coiiaeaia ia o?eueee iaoeiaeie oai?aoe/ieie
?ioa?anaie, aea ? i?aeoe/ieie caaaeaiiyie ioi?iie caei?ia’y,
i?iaaaeaiiyi aeeniaina?ecaoe??, cae?eniaiiyi iaaeeei-aaiaoe/iiai
eiinoeueooaaiiy, caaacia/aiiyi oai?eo e?ea?nueeeie i?aia?aoaie,
i?iaeaiaie i?a?aoe?? ianaeaiiy, canai?iiy iiaeo oa?eoi??e oa ?i.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iaoeia?
aeine?aeaeaiiy i?iaiaeeeeny a ?aieao oaie ?iaioe eaoaae?u aaiaoeee ?
oeeoieia?? OAO “No?oeoo?a iiioeyoe?? oa niaaeeiaa no?euei?noue aei
ioeueoeoaeoi??aeueieo caoai?thaaiue” (OAeE 575.1/. 2: 599.9, ?
aea?ae?a?no?aoe?? 0196U002581).

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoa aeine?aeaeaiiy – c’ynoaaoe
oa?aeoa? oniaaeeoaaiiy ini??aco, eiai ??cieo ee?i?/ieo oi?i, aaiaoe/iee
ca’ycie i?ae ieie ? ca’ycie c? no?oeoo?ith iiioeyoe??.

A ca’yceo c oeei aoee iinoaaeai? oae? caaaeaiiy:

1. I?iaanoe aaiaoe/iee aiae?c ini??aco, a?aoiaoth/e ee?i?/iee
iie?ii?o?ci caoai?thaaiiy.

2. Aea/eoe aieea aaiaoeei-aeaiia?ao?/ieo iniaeeainoae iiioeyoe?? ia
iai?oanoaoe?th caoai?thaaiiy.

3. I?iaiae?coaaoe ?iciianthaeaeai?noue ini??aco a ??cieo aoi?/ieo a?oiao
oa aaia?ao?/ieo ciiao.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Aaoi?ii aeine?aeaeaia aaiaoe/ia
aeaoa?i?iaoe?y ini??aco, aea/aii oaiiiai eiai ee?i?/iiai iie?ii?o?cio,
noai?aia aaeaeaaoia iiaeaeue eiai oniaaeeoaaiiy oa aea/aii iniaeeaino?
eiai iai?oanoaoe?? a oiiaao iiioeyoe?e c ??cieie ??aiai o?aai?caoe?? oa
ee?iaoi-aaia?ao?/ieie oiiaaie.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Cai?iiiiiaaia iiaeaeue
oniaaeeoaaiiy aeicaiey? ooi/ieoe ioe?iee ?eceeo caoai?thaaiiy c
o?aooaaiiyi ee?i?/ieo oi?i oa aoi?/ieo iniaeeainoae i?iaaiae?a na?aae
?oi?o ?iaee/?a, ui iiaeooue aooe aeei?enoai? i?e iaaeeei-aaiaoe/iiio
eiinoeueooaaii?.

Ioe?iee ?eceeo iieacai? o aeaeyae? oaaeeoeue ?eceeo, ui aa?eoee a
“Iaoiaee/i? ?aeiiaiaeaoe?? aeey aaiaoe/iiai i?iaiico ?icaeoeo ini??aco”.
Aaiaoe/i? ioe?iee noeeueiino? aei ini??aco ai?iaaaeaeothoueny a
e?eoaaeueii-ae?aaiinoe/io ?iaioo Oa?e?anueeiai iaeaniiai ee?i?/iiai
oe??ii-aaia?ieia?/iiai aeeniaina?o, oaeiae iiaeooue aooe aeei?enoai? a
?ioeo iaaee/ieo ? e?eoaaeueieo onoaiiaao e?ea?yie.

?acoeueoaoe aeine?aeaeaiue aeei?enoiaothoueny i?e aeeeaaeaii? eo?n?a
“Aaiaoeea ethaeeie”, “Aaiaoe/iee aiae?c” eaoaae?e aaiaoeee ? oeeoieia??
OAeO, oaeiae iiaeooue aooe aeei?enoai? a ?ioeo aeueo iaa/aeueieo
caeeaaeao Oe?a?ie, aea /eoathoueny a?ieia?/i? ? iaaee/i? aeenoeeie?ie.
Eiii’thoa?i? i?ia?aie, noai?ai? a i?ioean? ?iaioe ai?iaaaeaeaii? a
iaa/aeueiee i?ioean i?e aeeeaaeaii? eo?n?a “Iaoaiaoe/i? iaoiaee a
a?ieia??” ? “Noaoenoe/i? iaoiaee a aaiaoeoe?”.

C?a?aia a i?ioean? ?iaioe aeieoiaioaoe?y aeei?enoiao?oueny i?e
aeeiiaii? eo?niaeo ? aeeieiiieo ?ia?o nooaeaioaie a?ieia?/iiai
oaeoeueoaoo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?eii? ?iaioe
aeiiia?aeaeenue ? iaaiai?ai? ia: aeaio eiioa?aioe?yo iieiaeeo a/aieo
a?ieia?/iiai oaeoeueoaoo OAeO (1996?., 1997?. Oa?e?a), ia ?? c’?cae?
iaaee/ieo aaiaoee?a Oe?a?ie (i. Euea?a, 1995?.), ia ainueiie
eiioa?aioe?? Jahrestagung der gesellschaft fur human genetuk (Gottingen,
1996 ?.).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii n?i ?ia?o a
iaoeiaeo aeo?iaeao, ca??eao iaoeiaeo ?ia?o, iaoa??aeao ? oacao
eiioa?aioe?e.

Ia’?i oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 109 noi?
iaoeiiiai oaenoo, yeee i?noeoue 44 oaaeeoeue, 6 iaethie?a; neeaaea?oueny
c anooio, iaeyaeo e?oa?aoo?e, ?icae?eo, i?enay/aiiio iaoa??aeai oa
caniaai, aeei?enoaiei o ?iaio?, 10 ?icae?e?a iniaenoeo aeine?aeaeaiue oa
aeniiae?a; a?ae?ia?ao?/iee iieaciee neeaaea?oueny c 141 aeaea?aea.

IAOA??AEE OA IAOIAeE AeINE?AeAEAIUe

Na?? aaiaaeia?/iiai iaoa??aeo (Ia?oe, *aec, 1979) o i. Oa?eia? oa
Oa?e?anueeie iaeano? i?iaaaeaia caniaii iaeeie/ii? ?a?no?aoe??
(Cavalli-Sforza, 1971) ia aac? Oa?e?anueeiai iaeaniiai ee?i?/iiai
oe??ii-aaia?ieia?/iiai aeeniaina?o (aaoi? ae?aaea? aaeeeo iiaeyeo
iaoeiaiio eiinoeueoaioo aieiaiiio e?ea?th I.I.?eaeei ca ieacaio
aeiiiiiao) oa a?aeae?eaiiy aea?iaoieia?? Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo aea?iaoieia?? oa aaia?ieia?? (aaoi?
ae?aaea? iiaeyeo caa?aeoth/ae a?aeae?eaiiyi ss.O.Eooanaa?/).

Io?eiaia aaiaaeia?/ia ?ioi?iaoe?y i?i 147 ae?iie ? 253 /ieia?e?a a?eii
a?ae 11 aei 80 ?ie?a, oai?eo ia ??ciiiai?oi? oi?ie ini??aco. Oaiioeie
i?iaaiae?a ? ?iaee/?a ioe?ithaaeeny ii ae?aaiicao e?ea??a ? i?e aea/aii?
iaaee/ii? aeieoiaioaoe??. ?iciianthaeaeai?noue ini??aco ii caii?e eoe?
aea/aeany ca aeaieie na?oiai? eeoa?aoo?e.

Noaoenoe/ia ia?iaea ?acoeueoao?a i?iaaaeaia caaaeueiii?eeiyoeie
ia?aiao?e/iei? oa iaia?aiao?e/ieie iaoiaeai? (Eaeei, 1990).
Naa?aaaoe?ei? /anoioe oa ?o iiieee? ae?aoiaoaaeenue ca oi?ioeaie aeey
iaoiaea iaeeie/ii? ?a?no?aoe?? (Cavalli-Sfortha, 1971). Eiiiiiaioiee
aiae?c i?iaaaeaii c aeei?enoaiiyi eiao?oe??io?a ei?aeyoe?? i?ae
?iaee/ai?, ye? ae?aoiaai? ca ??aiyiiyi? aeueoa?iaoeaii? oa
eaac?iai?a?eaii? iiaeae? oniaaeeoaaiiy (Falconer, 1965, Mendell, 1974,
Elston, 1974). Ioe?iea ia?aiao??a iiaeae? aieiaiiai aaia c iaiiaiith
iaiao?aioi?noth io?eiaia oeyoii ??oaiiy ae?nia?n?eieo ??aiyiue (James,
1971). Aaiaoe/iee ?ecee ?ic?aoiaai ca iaoiaeiie Morton, (1969), Smith,
(1971). Ae?aoiaaie anioe?aoe?? ini??aco c eioei? caoai?thaaiiyi?.
Ia/eneaiiy aeeiiai? ia IBM-486 DX2 c aeei?enoaiiyi III GAP, ?ic?iaeaiei
i?e ni?eueii? ?iaio? eaoaae?e aaiaoeee oa oeeoieia?? OAeO oa eaoaae?e
ANO OAO. (Aaoi? ae?aaea? aaeeeo iiaeyeo E. I. Iaoaoe?io, ?. I.
Iao?aea?ao, I. A. Cai/aieo, A. A. Ioioyio ca ieacaio aeiiiiiao i?e
eiiiuethoa?i?e ia?iaoe? aeaieo, O.O. Ei?iaei ca aeiiiiiao i?e
?aaeaaoaaii? aaoi?aoa?aoo).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O
IAAIAI?AIIss

A ca’yceo c oei, ui /anoioa iaeiiai ? oiai aea caoai?thaaiiy iiaea aooe
??ciiiai?oiith a ??cieo ?aa?iiao, aoi?/ieo a?oiao, aoei i?iaaaeaia
aea/aiiy ?iciianthaeaeaiino? ini??aco a Oa?e?anuee?e iaeano?.
?iciianthaeaeai?noue ini??aco a Oa?e?anuee?e iaeano? ?ic?aoiaoaaeany ia
eiio?ieuei?e a?oi?, yea i?noeea 186 ae?iie ? /ieia?e?a a?eii a?ae 0 aei
60 ?ie?a oa iiiaae 1500 ?oi?o ?iaee/?a ia?oiai oa ae?oaiai nooiai?a
nii??aeiaiino?. ?acoeueoaoe aeine?aeaeaiiy na?ae/aoue i?i a?eicaeaaeio
i?e?iaeo caoai?thaaiiy, ui i?aeoaa?aeaeo?oueny ? aeaieie ?ioeo aaoi??a
(Aeiaaeaineee , Oooe , 1992, Iniaiiaa , 1985, Ea?aaeiia , 1983). *anoioa
ini??aco o ae?oae a oa?e?anuee?e iiioeyoe?? neeaaea? aeecueei 0.53%,
/anoioa ini??aco aeey in?a na?aaeiueiai a?eo neeaaea? 0.71%, /anoioa
ini??aco na?aae aaouee?a in?a eiio?ieueii? a?oie ??aia 0.80%, caaaeueia
/anoioa ini??aco ii oa?e?anuee?e iiioeyoe?? — 0.71%. A a?aeiia?aeiino? c
ee?i?/ieie iniaeeainoyie ini??aco i?iaaiaee aoee iiae?eai? ia aea?
a?oie: ia?oa ia’?aeio? oai?eo c oeie oi?iaie ini??aco, ui
oa?aeoa?ecothoueny o?aaeaiiyie oe??e aac o?aaeaiue noaeia?a. Ae?oaa
a?oia — oai?eo c oaeeie aea oi?iaie ini??aco, aea oneeaaeiaieie
a?o?iiaoe?th. *anoea a?o?iiaoe/iiai ini??aco o oa?e?anuee?e iiioeyoe??
(16.5%) ni?aiaaea? c aeaieie ii ?ioeo iiioeyoeeyo – 5-30% (Y?aean,
Ea?aaeiia, 1985). Aea/aiiy ni?aa?aeiioaiiy oi?i ini??aco iieacaei, ui o
oa?e?anuee?e iiioeyoe?? /anoea a?eo?iaea?i?? aeua, yenoaeaoeaiiai
ini??aco – ieae/a, eeane/iiai, cae/aeiiai, ini??aco oaea ae, ye ? a
?ioeo iiioeyoe?yo. Iiaeeeai, a?aei?iiino? iia’ycai? c iniaeeainoyie
ia?aa?ao ini??aco a aeaiiio ?aa?ii? aai iaaaeeeith e?euee?noth aeaieo
i?i ?io? iiioeyoe?? aeey ii??aiyiiy, aai ??ciiiai?oieie ae?aaiinoe/ieie
e?eoa??yie. Aiae?c ?iaeiaiae?a iieacaa, ui oai?? ia ini??ac ?iaee/?
i?iaaiae?a neeaaeathoue 2.0-11.9%, ui a 3-17 ?ac?a (?<0, 01) ia?aaeuo? eiai na?aaeiueiiiioeyoe?eio ?iciianthaeaeai?noue. Oaaeeoey I Aaiaaeia?/ia oa?aeoa?enoeea A?oia Noaoue?iaee/?, ui ii?aaeai?,%1 nooi?iue nii??aeiaiino?2 nooi?iue nii??aeiaiino?AE?iie*ieia?e.A na?aae-iueiioAE?iie*ieia?e.A na?aae-iueiio Caaaeueia ae?ii/a /ieia?/a anueiai5.8 5.0 5.38.2 7.7 7.97.1 6.3 6.64.8 3.1 3.73.4 3.3 3.44.1 3.2 3.5 Ia?oa ae?ii/a /ieia?/a anueiai4.5 4.5 4.47.9 8.2 7.96.3 6.3 6.35.5 1.9 4.42.8 2.1 2.34.2 2.0 3.6 Ae?oaa ae?iie /ieia?/a anueiai11.9 4.3 7.29.4 8.2 8.710.4 6.3 8.02.5 1.9 2.15.3 2.0 3.53.9 2.0 2.8 Oaeei /eiii, aaiaaeia?/iee aiae?c ia aeyaea a?aei?iiino? a aaiaoe/i?e iaoyaeaiino? o oai?eo ??cii? noao? ? oai?eo c ??ciiiai?oieie oi?iaie caoai?thaaiiy ii ?iaee/ao ia?oiai ? ae?oaiai nooiaiy nii??aeiaiino?. Niinoa??aa?oueny eeoa iacia/ia c?ooaiiy a noi?iio a?eueoi? aaiaoe/ii? iaoyaeaiino? ae?iie o ii??aiyii? c /ieia?eaie ? ae?iie ae?oai? a?oie o ii??aiyii? c ae?ieaie ia?oi? a?oie. Io?eiai? ?acoeueoaoe ni?aiaaeathoue c aeaieie ?yaeo aaoi??a (Ii?aeiaoeaa, Iooao, Aeueaaiia, 1991, Aeiaaeaineee, 1992, Anderson, Voorhest, 1986) i?i oa, ui ia niinoa??aa?oueny ??cieoe? a aaiaoe/i?e iaoyaeaiino? i?ae ae?ieaie ? /ieia?eaie (niinoa??aa?oueny a?eueoa aaiaoe/ia iaoyaeai?noue ae?iie, yea a??ia?aeii ia a?ae??ciy?oueny a?ae iaoyaeaiino? o /ieia?e?a) ? i?ae oi?iaie ini??aco, oneeaaeiaieie a?o?iiao?ath ? ia oneeaaeiaieie. Oaaeeoey II Naa?aaaoe?eiee aiae?c A?oiaOaii-oeie aaouee?aE?eue- e?noue n?iaeE?eue-e?noue ae?oaeE?eue-e?noue o?aaea-ieo ae?oae SF mSF SFd SFr P Ia?oa NN NA 295 39 701 98 31 9 0.076 0.153 0.013 0.047 0 0.5 0.25 0.5 <0, 05 <0, 05 Ae?oaa NN NA 55 11 145 27 10 2 0.111 0.125 0.053 0.083 0 0.5 0.25 0.5 >0, 05

<0, 05 Caaaeueia NN NA 350 50 846 125 41 11 0.083 0.147 0.012 0.041 0 0.5 0.25 0.5 <0, 05 <0, 05 I?iaaaeaiiy eeane/iiai naa?aaaoe?eiiai aiae?co aeeeeeaii iaiao?aei?noth noai?aiiy aaeaeaaoii? iiaeae? oniaaeeoaaiiy caoai?thaaiiy Io?eiai? aeai? iieacothoue, ui oei oniaaeeoaaiiy ini??aco ia a?aeiia?aea? iiiiaaiii? iiaeae? c iiaiith iaiao?aioi?noth. Naa?aaaoe?ei? /anoioe c aenieith a??ia?aei?noth a?aeeeaeathoue iaiaeaeaanueeo iiaeaeue oniaaeeoaaiiy ini??aco a oe?eiio, ui ni?aiaaea? c aeaieie ?ioeo aaoi??a (Ea?aaeiia, 1983).Oaeei /eiii, aeai? aaiaaeia?/iiai ? naa?aaaoe?eiiai aiae?co aeathoue i?aenoaao aeey iiaeaeueoiai oanooaaiiy eaaceaacia?a?aii? iiaeae? Oaeeiia?a. I?aenoaa aeey i?eeiyooy a?iioace i?i aaiaoe/io aaoa?iaaii?noue oe??yieo oi?i ini??aco ? oi?i, oneeaaeiaieo a?o?iiao??th, ca ?acoeueoaoaie aeine?aeaeaiue, iaia?. Ocae/a?ia oi/ea ci?o i?i ioeueoeoaeoi??aeueiee oa?aeoa? oniaaeeoaaiiy ini??aco a?oioo?oueny ia /eneaiieo aeaieo i?i ?iaeeiia iaeiie/oaaiiy ini??aco ? iaa?aeiia?aei?noue eiai oniaaeeoaaiiy i?inoei iaiaeaeaanueeei iiaeaeyi. Iaeiae iiiyooy “ioeueoeoaeoi??aeuei?noue” aeeth/a? ca naaa oe?ieee niaeo? aa??aio?a oniaaeeoaaiiy - a?ae iiiiaaiiuo iiaeaeae c iaiiaiith iaiao?aioi?noth aei /enoi aaeeoeaiiai oniaaeeoaaiiy (Aaiaaieaineay, 1991). C iaoith ciaoiaeaeaiiy ia?aiao??a, ui aaeaeaaoii iienothoue ?iciiae?e caoai?thaaiiy a iiioeyoe??, i?iaaaeai ?iceeaae caaaeueii? oaiioei?/ii? aeenia?n?? a ?aieao eaaceaacia?a?aii? iiaeae?. Aoei iieacaii aaaiiee aieea aaiaoe/ieo oaeoi??a a aeaoa?i?iaoe?? caoai?thaaiiy – aaiaoe/ia neeaaeiaa aei??aithaaea 1. Ioe?iea oniaaeeiaaiiino? a “aocueeiio ?icoi?ii?” neeaaeaea 73,1%. Oaeiae aoei iieacaii iayai?noue iae?iaeii? i?aeaeaeueii? aca?iiae?? – Gd=0,354. Ona oea aeicaieeei i?eionoeoe, ui oniaaeeoaaiiy ini??aco iiaea cae?enithaaoeny o ?aieao iiiiaaiii? iiaeae? c iaiiaiith iaiao?aioi?noth. Aeey aea/aiiy nooiaiy iaiao?aioiino? aoei aeeiiaii aaiaoe/iee aiae?c a ?aieao aeueoa?iaoeaii? iiaeae?. Io?eiai? ?acoeueoaoe ni?anoaai? c aiaeia?/ieie aeaieie ii ?ioeo iiioeyoeeyo. ?acoeueoaoe eiiiiiaioiiai aiae?co, c?iaeai? ia ?iaeeiiiio iaoa??ae? aeeoae?a Oa?a?ne?o ino?ia?a iieacothoue, ui oniaaeeiaai?noue ini??aco a ?aieao eaaceaacia?a?aii? iiaeae? neeaaeathoue 0.87 (Lindsten, Breadberg, Iselius, Lambert, Markusson, Soderhall, 1981). A ?iaioao iieuenueeeo aaoi??a (Pietzuk, Turowski, Kapinska-Morowska, Rozenski, 1982) ia aea??oe?, yea neeaaeaeany c 244 n?iae, iieacaia, ui oniaaeeiaai?noue neeaaea? 0.82, ui ni?anoaaii c aeaieie ii oa?e?anuee?e iiioeyoe??. A ?aieao aeueoa?iaoeaii? iiaeae? aeey ini??aco a oe?eiio aaee/eia oniaaeeiaaiiino? Gt=0.228, a??ia?aeieo a?aei?iiinoae ii oeueiio ae iieacieeo i?ae ia?oith ? ae?oa?e a?oiaie iaia?. Aeey ae?iie ? /ieia?e?a a caaaeuei?e aea??oe? ? a a?oiao a??ia?aeieo a?aei?iiinoae ii aaee/ei? oniaaeeiaaiino? oaeiae ia aeyaeaia. *anoioa aaia ? iaiao?aioi?noue aiii - ? aaoa?iceaio ?ic?aoiaaia ca ??aiyiiyie aeey aeueoa?iaoeaii? iiaeae? c o?aooaaiiyi Rp ? Rop – eiao?oe?aio?a ei??aeyoe?? i?ae ?iaee/aie. I?e ??oaii? aeenia?n?eieo ??aiyiue iaea?aeothoueny ??ciiiai?oi? aa??aioe ??oaiiy aeey ??cieo oi?i ini??aco. Aeey ini??aco a oe?eiio ioe?iee ia?aiao??a iiiiaaiiie iiaeae? c iaiiaiith iaiao?aioi?noth oaee: /anoioa iaoieia?/iiai aaia p=0, 038, iaiao?aioi?noue aaoa?ic?aio I1=7, 2%, aiiic?aio I2=89, 1%. Oe? iieacieee icia/athoue, ui 2.4% ianaeaiiy oa?e?anueei? iiioeyoe?? ? aaoa?ic?aioieie iin?yie aaia ini??aco, a 0.4% - aiiic?aioaie ii oeueiio aaio. I?e oeueiio 0.17% iiioeyoe?? – oea oai?? ia ini??ac aaoa?ic?aioe, a 0.36% - oai?? ia ini??ac aiiic?aioe. Ca aeaieie ?ioeo aaoi??a, aiae?c iiiiaaiii? iiaeae? c iaiiaiith iaiao?aioi?noth iieaco? neeueiee aieea aieiaiiai aaia, /anoioa yeiai neeaaea? ?=0, 07 (Lindsten, 1981) ia Oa?a?nueeeo ino?iaao, ?=0, 05 (Swanbeck, 1994) a Oaaoe??. Aaoi?aie i?eionea?oueny a?aeiia?aei?noue oeio oniaaeeoaaiiy ini??aco aooiniiii? ?aoeaneaii? iiaeae? (Swanbeck, Inerot, Mastintion, Wahlstrom, 1994, Aa?aeuoaa, E?eai?o/ei, 1990, Pietzuk, Turowski, Kapinska-Morowska, Rozenski, 1982), ui ia noia?a/eoue io?eiaiei aeaiei ii oa?e?anuee?e iiioeyoe??. Ia i?aenoaa? io?eiaieo aaiaoe/ieo iieaciee?a - naa?aaaoe?eieo /anoio ? eiao?oe?aioa oniaaeeiaaiino? c aeiiiiiaith oaaeeoeue ?aeo?aioiiai ?eceeo iiaeia c?iaeoe i?iaiic ?icaeoeo ini??aco aeey aoaeue-yei? ethaeeie, ui ia? aaeeea cia/aiiy aeey iaaeeei-aaiaoe/iiai eiinoeueooaaiiy. Oey i?ioeaaeo?a aeicaiey? aeyaeoe a?oio i?aeaeuaiiai ?eceeo ii ini??aco aeey oe?eani?yiiaaii? ia?aeiii? i?io?eaeoeee caoai?thaaiiy. ?icaeyae oaeiai iieacieea, ye ni?aa?aeiioaiiy noaoae na?aae oai?eo ia ini??ac, iieacaei ia?aaaao /ieia?/i? noao? iaae ae?ii/ith – 147 ae?iie: 253 /ieia?ee (?<0, 05). Oea iiaeia iiynieoe aoi?eiiei aai o?aoeiiei ni?aa?aeiioaiiyi noaoae a iiioeyoe??, aeeeeeaiei ??ciiiai?oieie aeaiia?ao?/ieie i?ioeanaie – aeeoa?aioe?aeueiith nia?oi?noth, ??ciith o?eaae?noth aeeooy /ieia?e?a ? ae?iie ? o. ae., aai ae iaiaeiaeiaei caa?oaiiyi ae?iie ? /ieia?e?a a e?eoaaeuei? onoaiiae. Ii??aiyiiy ia?oi? ? ae?oa?e a?oi ii a?aenioeo oai?eo /ieia?e?a ia iieacaei a??ia?aeieo a?aei?iiinoae i?ae ieie - 64.9% /ieia?e?a a ia?o?e a?oi? ? 54.5% /ieia?e?a a ae?oa?e a?oi?, aeey ae?iie ii oeueiio iieacieeo oaae a??ia?aeieo a?aei?iiinoae ia iieacaii - 35.1% ae?iie ? 45.5% ae?iie . ?acoeueoaoe aaiaaeia?/iiai aiae?co iieacothoue, ui caoai?thaaiiy ia caeaaeeoue a?ae noao?, ai a?aenioee ii?aaeaieo ?iaee/?a ae?ii/i? ? /ieia?/i? noao? i?iaaiae?a ??cii? noao? c ??ciiiai?oieie oi?iaie ini??aco a??ia?aeii ia ?ic??ciythoueny. ?ioi?iaoeaiei iieacieeii, ui a?aeaeaathoue aieea n?aaeiaeuieo ? aaiaoe/ieo /eiiee?a ia caoai?thaai?noue, ? a?e, a yeiio aeieeei caoai?thaaiiy. Oiio i?iaaaeaia aeine?aeaeaiiy a?eo ii/aoeo caoai?thaaiiy aeey ini??aco a oe?eiio, aeey ia?oi? ? ae?oai? a?oi ? aeey ie?aieo oi?i o /ieia?e?a ? ae?iie. Io?eiai? ?acoeueoaoe iieacaee, ui aeey caaaeueii? aea??ee ? ia?oi? a?oie ??cieoey i?ae ae?ieaie ? /ieia?eaie ii oeueiio iieacieeo a??ia?aeia – o ae?iie ini??ac ii/eia?oueny a na?aaeiueiio ia 4-4,5 ?ieo ?ai?oa (p<0, 01), ui ni?aiaaea? c aeaieie ?ioeo aaoi??a (Aeiaaeaineee, 1992). Oaaeeoey III A?e ii/aoeo caoai?thaaiiy A?oiaNa?aaei?e a?e ii/aoeo ini??aco, o mx t?Caaaeueia A oiio /ene?24.435 0.6130AE?iie22.82 0.9708.09?<0, 01*ieia?e?a26.95 0.780 Aeai? i?i a?e ii/aoeo ini??aco iiaeooue aooe iieacai? oaeiae a a?ao?/iiio aeaeyae?. ?en I ?iciiae?e i?iaaiae?a ca a?eii ii/aoeo caoai?thaaiiy. Iaea?eueoa e?euee?noue ethaeae, ui caiaaeoaeaee, niinoa??aa?oueny a a?eiaeo a?oiao 20-29 ? 10-19 ?ie?a. Io?eiaiee iaea?eueoee ?ecee ?icaeoeo ini??aco a a?eo a?ae 10 aei 29 ?ie?a c?noaaeii c aiaeia?/ieie aeaieie ii ?ioeo iiioeyoe?yo – na?aoianuee?e, iineianuee?e – 11-29 ?ie?a . ?noioieo a?aei?iiinoae a a?eo ii/aoeo ??cieo oi?i caoai?thaaiiy, ui iiaee a aooe iieeaaeai? a iniiao eeaneo?eaoe?? ini??aco ye “?aiiueiai” aai “i?caeiueiai”, ye oea ia? i?noea i?e ?ioeo ?iciianthaeaeaieo oai?iaao c? niaaeeiaith noeeuei?noth (Ooaiaeaeue, 1996), ia aeyaeaii. I?iya ? ?iciianthaeaeai?noue niaaeeiaeo oai?ia a iiioeyoe?? cae/aeii caeaaeaoue a?ae ?? aeaiia?ao?/ieo ? aoi?/ieo oa?aeoa?enoee. sse a?aeiii, i?nueea ? n?euenueea na?aaeiaeua a?ae??ciythoueny ca icaeaiaiiyi, caa?oaeiaiiyi iia?o?yiiai ? aiaeiiai aanaei?a, ineo?/iiai ? o?ce/iiai aaioaaeo o?aaiecaoe??. E??i oiai, i?nueea na?aaeiaeua aein? ua ia ? i?e?iaeiith aeey ethaeeie (Aeoooia, Eo?aaoiaa, 1990). Oiio oaeee iieaciee, ye na?aaei?e a?e ii/aoeo ini??aco ?icaeyaeaany aeey iiioeyoe?e ??ciiiai?oiiai oeio - i?nueeeo, ?aeiiieo oeaio??a ? n?euenueeeo. ?acoeueoaoe iieacaee, ui a??ia?aeii? ??cieoe? i?ae aeeoaeyie i?noa (oae=22.71.189, o/=25.91.217), ?aeiiieo oeaio??a (oae=22.51.971, o/=26.31.440) ? n?e (oae=23.4 2.299, o/=28.51.519) ae?ii/i? ? /ieia?/i? noao? aeey ini??aco ? a oe?eiio, ii a?oiao ii oeueiio iieacieeo ? ii ni?aa?aeiioaiith oi?i ini??aco ana?aaeei? eiaeii? c a?oi iaia?. Oiio iiaeia aiai?eoe i?i oa, ui aeieia?/i? /eiieee, ye? ??ci? o i?no? oa nae?, ia a?athoue aecia/aeueii? ?ie? a ?icaeoeo ini??aco, ui ua ?ac ?ethno?o? a?aenooi?noue aieeao na?aaeiaeuieo oaeoi??a ia oniaaeeoaaiiy caoai?thaaiiy. I?e aeine?aeaeaii? i?iyao ini??aco o i?iaaiae?a a?aoiaoaaee oaeee /eiiee, ye nooi?iue aeciaai?? aaouee?a. ?iciiae?e i?iaaiae?a oa in?a eiio?ieueii? a?oie ii nooiaiyi aeciaai?? a??ia?aeii ?ic??ciy?oueny o?euee? aeey ae?iie I oa IV nooiai?a aeciaai?? (?<0.05).Io?eiai? aeai? iieacaee, ui i?e ini??aca, ia a?aei?ii?noue a?ae aaaaoueio caoai?thaaiue c niaaeeiaith noeeuei?noth, aiia ia aeyaey? aieeao ia oae? iieacieee, ye a?e ii/aoeo caoai?thaaiiy, ?icaeoie o i?iaaiae?a oeo, a ia ?ioeo oi?i ini??aco. Oaaeeoey IV ?iciiae?e i?iaaiae?a ia?oi? ? ae?oai? a?oie a caeaaeiino? a?ae nooiaiy aeciaai?? aaouee?a, ui ianoaaeeeeny Nooi?iue aeciaai??E?euee?noue,%?E?euee?noue,% A?oie ae?iie. /ieia?e.eiio?ie ae?iie.eiio?ie/ieia?e. ia?oa,% ae?oaa,%I17.7 53.7 25.213.0 45.9 32.8 8.3p>0, 05

p>0, 05

p>0, 05

p>0, 05 7.4

44.0

33.0

13.7 7.8

37.0

42.0

12.814.4

49.4

30.2

6.016.7

45.5

28.8

9.1IIIIIIV3.4

Na?aaei?e a?e ii/aoeo ini??aco o ae?iie ? /ieia?e?a aeey ??cieo
nooiai?a yeciaai?? a??ia?aeii ia ?ic??ciy?oueny, oiae? ye aeey
caoai?thaaiue, ui oa?aeoa?ecothoueny aaiaoe/iith aaoa?iaaii?noth,
oa?aeoa?ii a?eueo i?ci?e ii/aoie iai?oanoaoe?? caoai?thaaiiy o in?a
cieaeaii? aeciaai??. *ei a?eueoa oethaia a?aenoaiue aaouee?a, oei aeua
nooi?iue aaoa?ic?aioiino? iioiinoaa, a oea ? iiaeeea?noth i?iyao oeo aai
?ioeo aai?a (Aeoooia, 1989). Aoaeoe ?ia??ae?iaa ? aooa??ae?iaa
aieeaathoue ia i?iya ?aoeaneaieo aai?a, o yeeo a?eueoa ?iia??i?noue
aeyaeoeny a aiiic?aio?. Aeey ini??aco ia aeyaeaii aieeao nooiaiy
aeciaai?? aaouee?anueei? ?aia?aoe??, ui aiai?eoue i?ioe iiiiaaiii? ?
iie?aaiii? ?aoeaneaii? eiai i?e?iaee.

Ini??ac i?eeiyoi aaaaeaoe nenoaiiei caoai?thaaiiyi, oiio ieoaiiy i?i
ca’ycie ini??aco c ?ioeie iaoieiaeyie ?icaeyaeaeiny ??cieie aaoi?aie.
Aeey oiai, uia ii??aiyoe noeeuei?noue /ieia?e?a ? ae?iie aei ?yaeo
caoai?thaaiue, aoee iiaoaeiaai? ?yaee ?iciiae?eo ??ciiiai?oieo
caoai?thaaiue aeey /ieia?e?a ? ae?iie ana?aaeei? eiio?ieueii? ? iniiai?e
a?oi, ui a??ia?aeii ia ?ic??ciythoueny. Aeey /ieia?e?a eiio?ieueii? ?
iniiaii? a?oi ??cieoey i?ae ?yaeaie ?iciiae?eo a??ia?aeia (O2=36.1, ?<0, 05). Aeey ae?iie ??cieoey ii oeueiio aea iieacieeo oaeiae a??ia?aeia (O2=42.4, ?<0, 05). Ii??aiyiiy ae?iie eiio?ieueii? ? iniiaii? a?oi ii eiaeiiio c caoai?thaaiue iieacaei, ui na?aae oai?eo ia ini??ac ae?iie /ano?oa (?<0, 05) cono??/athoueny caoai?thaaiiy aeae?ethaaeueii? nenoaie ? ??aeoa (?<0, 05) – caoai?thaaiiy aeeoaeueii? nenoaie. Aeey /ieia?e?a ?acoeueoaoe aeine?aeaeaiue iieacaee a?eueoo /anoioo (?<0, 05) caoai?thaaiue na?oeaai-noaeeiii? nenoaie, oeoieiai-eeoeiaiai o?aeoo ? iii?ii-?ooiai? nenoaie. Io?eiai? aeai? ocaiaeaeothoueny c aeaieie ?ioeo aaoi??a, a?aei?iiino? ae i?ae /ieia?eaie ? ae?ieaie ii anioe?aoe?yo o ieo ini??aco c ??cieie caoai?thaaiiyie iiaeia iiynieoe aai ??ciith noeeuei?noth /ieia?e?a ? ae?iie acaaae? aei ??ciiiai?oieo oai?ia, aai ??cieoeath a ui iia?aeiieai?e ?ioi?iaoe?? i?e cai?? aeaieo. I?iaaaeaia aeine?aeaeaiiy ?iciianthaeaeaiiy ini??aco a ??ciiiai?oieo aaia?ao?/ieo ? ee?iaoe/ieo oiiaao, ?aniaeo ? aoi?/ieo a?oiao, a aaaaoueio e?a?iao ? ?aa?iiao. A i?ioean? aaiethoe?? ethaeeie a eiie?aoieo ee?iaoi-aaia?ao?/ieo oiiaao noi?ioaaeeny oaiioeie ethaeae, iaea?eueo aaeaioeai? aei ?nioaaiiy a ieo. Oiio iiaeia ?icaeyaeaoe ?iciiae?e /anoioe ini??aco a ??ciiiai?oieo ?aniaeo ? aoi?/ieo a?oiao (O?enaioiaa, 1991). Iaea?eueo aeniea /anoioa ini??aco niinoa??aa?oueny a Ii?aaa??, Oaaoe??, Aeai??, Aaeeeia?eoai??, ia Oa?a?nuee?o ino?iaao. Ianaeaiiy oeeo e?a?i neeaaeathoue i?aaenoaaieee i?ai?/ii? a?oie aio?iiieia?/ieo oei?a ?a?iiai?aeii? ?ane – aoeaioi-aaeo?enueei? iaei? ?ane. A oie aea /an na?aae eaieaiaeoe?a – aoi?/ii? a?oie, i?iaeeaath/i? ia i?aii/? Ii?aaa??, – /anoioa ini??aco aeoaea iaaeniea, o?eueee 0.60%. Eaieaiaeoe? iaeaaeaoue aei eaiiii?aeii? iaei? ?ane, yea noaea ?acoeueoaoii ci?uaiiy ?a?iiai?ae?a ? iiiaiei?ae?a a noa?iaeaaiino?, no/ani? i?aaenoaaieee ?? a?ae??ciythoueny niaaeyaith oe??ith, oaiiei aieinnyi ? oaiieie i/?ia. I?aaenoaaieee na?aaeiueiaa?iiaenei? iaei? ?ane oa?aeoa?ecothoueny a?eueo oaiii? ieaiaioaoeeae aiein ? i/ae, i?ae i?ai?/i? a?oie aio?iiieia?/ieo oei?a. Na?aae ianaeaiiy “iiyno oaoai?a” /anoioa ini??aco ?iciiae?ey?oueny oaeei /eiii: Eino?iia-1, 40%, Iineianueea iaeanoue – 0.75-0.97%, Na?aoia – 0.82%, Oa?e?a – 0.65-0.70%. Oaeei /eiii, a i?ai?/i?e i?aeoe? niinoa??aa?oueny cieaeaiiy /anoioe ini??aco c i?aii/? ia i?aaeaiue. Oaaeeoey V ?iciianthaeaeai?noue ini??aco na?aae aoeaioi-aaeo?enueei? iaei? ?ane ?aa?ii*anoioa ini??aco,%Aaeeea ?anaIaea ?anaIioiaeaeaiiyOa?a?nuee? ino?iae2.80-7.00 ?a?iiai?aeiaAoeaioi-aaeo?enueea Ii?aaa?y Eaieaiaeoe?4.82 0.60 Oa ae -Oa aea Eaiiii?aeia Aa?ii+iiiaieOaaoe?y2.30-6.25 Oa aeAoeaioi-aaeo?enueeaAeai?y3.29-4.18 - Oa aeaAaeeeia?eoai?y1.60-3.00 - Oa aea Na?aae i?aaenoaaiee?a aaeeaii-eaaeacueei? iaei? ?ane niinoa??aa?oueny oaea ?iciianthaeaeai?noue ini??aco: THaineaa?y – 1.58%, Aca?aaeaeaeai – 0.50%, Aeaaanoai – 0.72%, Aieaa??y – 0.21%. Aeai? i?i ?iciiae?e ini??aco na?aae i?aaenoaaiee?a ?iaei-na?aaeiueicaiiiii?nueei? iaei? ?ane oae?: Ocaae?noai – 1.20%, Oaaeae?e?noai – 0.47%, O??-Eaiea – 0.40%. Aeey ?a?iiai?aeii? (?a?ac?enueei?) aaeeei? ?ane niinoa??aa?oueny iiieaeaiiy /anoioe ini??aco a?ae i?ai?/iiai iiethno aei aeaaoi?a ana?aaeei? eiaeii? iaei? ?ane ? iiieaeaiiy /anoioe ini??aco a?ae i?ai?/iiai iiethno aei aeaaoi?a a?ae a?eueo i?ai?/ieo iaeeo ?an aei a?eueo i?aaeaiieo. Ac?y ?noioii a?eueo ??ciiiai?oia a aio?iiieia?/iiio a?aeiioaii?, i?ae ?a?iia. Ooo aeii?iothoue ??ciiiai?oi? iiiaiei?aei? ? ?a?iiai?aei? a?oie – aeaeaeino?aeia, i?aaeaiii-ac?aonueea, na?aaeiueicaiiiii?nueea ?ane, a?oie ci?oaiiai iioiaeaeaiiy. Aeaye? a?oie iaei ii?ooai? i?a?aoe?yi? ? ci?oaiiyi, oiio iiaea niinoa??aaoeny iiiaiei?aeia iiiiaoi?/i?noue, ye, iai?eeeaae, a ssiii??. Oeei, iaaii, iiaeia iiynieoe iecueeo /anoioo ini??aco a oe?e e?a?i?. ?iciiae?e /anoio ini??aco aeey aeaeaeino?aeii? iaei? ?ane: Iiiaie?y – 0.052% ? I?ai?/iee Eeoae – aei 0.42%, ii Eeoath a na?aaeiueiio – 0.06-0.42%, ssiii?y – 0.0068% (iecueeo /anoioo ini??aco na?aae ianaeaiiy Iiiaie?? nai? aaoi?e iiyniththoue iaoiaee/ieie iia??oiinoyie – aeei?enoaiiyi aeey iiioeyoe?eieo aeine?aeaeaiue a?o?aieo aeaieo). Aeey ?aa?ii?a i?aaeaiii-ac?aonueei? iaei? ?ane – i?aaeaiiiai Eeoath, Aiieiiao, /anoioa ini??aco a?aeiia?aeii neeaaea? 0.06% ? 0.05%. A na?aaeei? iaeeo ?an iiiaiei?aeieo aio?iiieia?/ieo oei?a caa?aaeany oaiaeaioe?y, aeyaeaia aeey ?a?iiai?aeii? ?ane – iiieaeaiiy /anoioe ini??aco a?ae i?ai?/iiai iiethno aei aeaaoi?a. Niinoa??aa?oueny oaeiae ? cieaeaiiy /anoioe a?ae a?eueo i?ai?/ieo iaeeo ?an aei a?eueo i?aaeaiieo. Na?aae i?ai?/iiaia?eeainueeeo ?iaeaeoe?a, ui iaeaaeaoue aei aia?eeainueei? ?ane (iiiaiei?aeiee aio?iiieia?/iee oei) ini??ac ia aeyaeaiee. Ini??ac na?aae aeeoae?a aeaaoi??aeueieo ?aeii?a Ao?eee ia aeyaeaiee. Aea aeey i?aii/? ao?eeainueeiai eiioeiaioo – Aeaee?, Ia?ieei, E?a?y – a?aecia/aia /anoioa ini??aco 0.8%. Iiaeeeai, oea iiynith?oueny oei, ui ianaeaiiy aeaiiai ?aa?iio iiaeaii ia o?eueee ao?eeainueeeie iaa?ieaeaie, aea ? i?aaenoaaieeaie ?iaei-na?aaeiueicaiiiii?nueei? iaei? ?ane, ai i?ai?/ia Ao?eea c aa?oiueiai iaeaie?oa canaeaia ?a?iiai?aeaie ? ? /anoeiith na?aaeiueicaiiiii?nueeiai ?aa?iio. Na?aae ieaai?enueeeo aano?aei?ae?a i?ai?/ieo, oeaio?aeueieo ? i?aaeaiieo ?aeii?a Aano?ae?? ini??ac ia aeyaeaiee. Oaeei /eiii, /anoioe ini??aco iaea?eueo aenie? na?aae i?aaenoaaiee?a ?a?iiai?aeii? ?ane. Niinoa??aa?oueny iiieaeaiiy /anoioe ini??aco a?ae i?ai?/iiai iiethno aei aeaaoi?a ana?aaeei? eiaeii? iaei? ?ane, a?ae a?eueo i?ai?/ieo iaeeo ?an aei a?eueo i?aaeaiieo, a?ae ?a?iiai?aeii? ?ane aei iiiaiei?aeii? ? iaa?i?aeii? aei iiaii? a?aenooiino? ini??aco . I?ioyaii iaeaea an??? aaiethoe?eii? ?noi??? ethaeeie ?ici??e eiai iiioeyoe?? aoee a?aeiinii iaeeie. Aeae aoa iiae?eeaiee ia ?yae iaaaeeeeo aioo??oi?o a?oi, ui no?auothoueny. Oiio /anoioe ini??aco aeey ??ciiiai?oieo iaeeo ?an a?ae??ciythoueny, aeaiiino?oth/e cieaeaiiy /anoioe ana?aaeei? a?oie c i?aii/? ia i?aaeaiue ? a?ae a?oie aei a?oie. Oea iiaea iiynithaaoeny i?enoiniaai?noth aeaii? ?ane aei ee?iaoe/ieo oiia (aei oeueo?ao?ieaoiaiai aei?ii?ithaaiiy, aei a?aae??ioa ?inieyoe??). Oa, ui /anoioe ini??aco aeey i?aaeaiieo i?aaenoaaiee?a i?ai?/ieo a?oi ieae/a, i?ae aeey i?ai?/ieo i?aaenoaaiee?a a?eueo i?aaeaiieo a?oi, iiaea iiynithaaoeny ??ciiiai?oiith i?enoiniaai?noth aei noiaeeo ee?iaoe/ieo oiia, coiiaeaiith ??ciiiai?oiith aaiaoe/iith i?e?iaeith, o?c?ieia?/ieie, ii?oieia?/ieie ? ?ioeoe iieacieeaie. Aeey iiyniaiiy a?aei?iiinoae a /anoioao aai?a a non?aei?o iiioeyoe?yo iiaeia aeei?enoaoe a?iioaco i?i ae?aeo aai?a (Oiaaeue, Iiooeuenee, 1990, Aeioa?, 1982). Iiaeeeai, ui /anoioe ini??aco ? a?aeiia?aei? /anoioe “aai?a” ini??aco a iiioeyoe?? iiaeooue neoaeeoe iaeieie c aaiaoe/ieo ia?ea??a aei o??? aai ?ioi? aaeeei? ?ane iaaieo aoi?/ieo a?oi. Oiio ?acoeueoaoe, io?eiai? ca aeiiiiiaith aaia?ao?/iiai i?aeoiaeo, iiaeooue aooe aeei?enoai? aeey aiae?co i?e?iaaiethoe?eieo i?ioean?a a iiioeyoe?yo ethaeeie. Aeey oeueiai iaiao?aeii aeae?eaiiy ie?aieo /eiiee?a a?aeai?o, ni?eyoeeaeo ?iciianthaeaeaiith ? caa?aaeaiith aai?a caoai?thaaiue a iiioeyoeeyo. Oiio o a?aeiioaii? ini??aco iaiao?aeii ?icaeyaeaoe oe?eee eiiieaen /eiiee?a. Iano?eueee ??ci? /anoioe o i?aaenoaaiee?a ??ciiiai?oieo a?eueoeo ?an iiaeia ni?iaoaaoe iiynieoe a?aei?iiinoyie a i?aiaioaoe?? eiae? ? /eii?noth a?aeai?o i?ae aieeaii niiy/ii? ?inieyoe??. Iiaeeeai, iaoai?cie neioaco iaeai?iiaeo iieaeoe, e?euee?noue iaeai?iiaeo a?aioe o iiaa?oi?o oa?ao eiae? ia?aoeiaeaeathoue ?icaeoeo ini??aoe/ieo i?ioean?a a ai?aea?i?n?, oiio ii i??? i?aeneeaiiy i?aiaioaoe?? oe??e ? ii i??? i?aeneeaiiy /eiiino? oeueo?ao?ieaoiaiai ii?ii?ithaaiiy a ??ciiiai?oieo aoi?/ieo a?oiao cieaeo?oueny /anoioa ini??aco. A?aeiii, ui ini??ac anioe?eiaaiee c nenoaiith HLA o ethaeeie. Iiaeia ?icaeyiooe oe? anioe?aoe?? o in?a ??ciiiai?oieo aoi?/ieo a?oi. Ne?ae a?aecia/eoe, ui aoi?/i? a?oie, ui aoiaeyoue a iaei? iae? ?ane, noiae? ii anioe?eiaaiei c ini??acii HLA aioeaaiai, oei a?eueoa, iiaeia aeae?eeoe ? caaaeuei? aeey a?eueoino? aoi?/ieo a?oi HLA oeie, anioe?eiaai? c ini??acii, oei a?eueo, ui aiie aeyaeythoueny c/aieaieie i?ae niaith, ye, iai?eeeaae, DRw7, B13 Cw6, B17 Cw6, DRw7. Oaeo oiai, ui a iaeieo aoi?/ieo a?oiao ini??ac anioe?eiaai?e c iaeieie aeaeyie HLA nenoaie, a a ?ioeo - c ?ioeie, iiaea na?ae/eoe i?i iayai?noue ??ciiiai?oieo aai?a, ui oi?iothoue noeeuei?noue aei ini??aco. Ieoaiiy i?i aaiaoe/io aaoa?iaaii?noue ??ciiiai?oieo oi?i ini??aco iiaeia ?icaeyaeaoe ua c iaei??? oi/ee ci?o. Aein? caeeoa?oueny a?aee?eoei ieoaiiy i?i aooi?ioiio i?e?iaeo ini??aco. Anioe?aoe?? c aooi?ioiiei? caoai?thaaiiyie iiaeooue aooe ca'ycai? aieiaiei /eiii (aai aeiyoeiai) c eieonii HLA-D/DR (Smolle, 1985). Aeaye? oi?ie ini??aco, caeaa?eueoiai ini??aoe/iee a?o?eo, anioe?eiaaiee c oeei aioeaaiii. AENIIAEE 1. A?aeeeiooa iiiiaaiia iiaeaeue oniaaeeoaaiiy c iiaiith iaiao?aioi?noth. 2. Oniaaeeiaai?noue ini??aco a ?aieao eaaceaacia?a?aii? iiaeae? neeaaea? 73,1%. 3. Iieacaii, ui oniaaeeoaaiiy ini??aco cae?enith?oueny a ?aieao iiiiaaiii? iiaeae? c iaiiaiith iaiao?aioi?noth. Ioe?iea ia?aiao??a iiiiaaiiie iiaeae? c iaiiaiith iaiao?aioi?noth aeaea oae? ?acoeueoaoe: /anoioa iaoieia?/iiai aaia ?=0.038, iaiao?aioi?noue aaoa?iceaio I1= 7.2%, aiiiceaio – I2=89.1%. 4. Ia aeyaeaii aieeao a?aeaeaeaiino? oethao aaouee?a ? nooiai? o?aaiecaoe?? ianaeaieo ioieo?a, a yeeo i?iaeeaathoue i?iaaiaee, ia ?iciianthaeaeai?noue ini??aco. 5. Niinoa??aa?oueny cieaeaiiy ?iciianthaeaeaiino? ini??aco a?ae i?ai?/iiai iiethna aei aeaaoi?a ana?aaeei? eiaeii? iaei? ?ane, a?ae i?ai?/i?oeo iaeeo ?an aei i?aaeaii?oeo ana?aaeei? a?eueoeo ?an, a?ae ?a?iiai?aeii? aaeeei? ?ane aei iiiaiei?aeiie ? iaa?i?aeiie. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. Ao?aiaioiaa E.A., Oaaeioa A.I. Eco/aiea ?ani?ino?aiaiiinoe ini?eaca a ?acee/iuo eeeiaoi-aaia?aoe/aneeo oneiaeyo e yoie/aneeo a?oiiao // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu – 1998. – N17 . – n. 3-5. 2. L.A. Atramentova, A.M. Fedota, I.M. Patrakeev. An Axample of Computer Genetic Analysis of Multifactorial Diseases // Fundamental Medicine Journal. – 1998. – v. 4, N1. – p. 79-80. 3. Oaaeioa A.I., Ai?iioeia A.I. Ia?niaeoeau aaiaoe/aneiai aiaeeca ini?eaca // A na. “No/ani? i?iaeaie a aea?iaoieia??, einiaoieia?? oa oi?aae?ii? ioi?iiith caei?ia’y”. – 1997. – N1. – n. 68-69. 4. ?uaeei I.I., Oaaeioa A.I., Oea/aiei N.A. E aii?ino aaiaoe/aneiai aiaeeca ini?eaca // A na. “No/ani? i?iaeaie a aea?iaoieia??, einiaoieia?? oa oi?aae?ii? ioi?iiith caei?ia’y”. – 1997. – N1. – n. 70-71. 5. Oaaeioa A.I., Iao?aeaaa E.I., Cai/aiei I.A., Ioioyi A.A. I aiciiaeiinoyo e eiae/aneie no?oeoo?a i?aaeiaoii-i?eaioe?iaaiiie aacu aeaiiuo GAP aeey aaiaoe/aneiai aiaeeca ini?eaca // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu – 1997. – N23. – n. 97-103. 6. Shagun S.V., Mavrov I.I., Fedota A.M., Atramentova L.A. The genetic analysis of psoriasis in the Ukrainian population // 8. Jahrestagung der gesellschaft fur human genetuk. – Gottingen. – 1996. – p. 42. 7. Oaaoi N.A., Oaaeioa A.I., Eai Ae., Iaeuei ?., Eooanaae/ ss.O., Iaa?ia ?.?., Aaeici?ia I.I. Ni?aa?aeiioaiiy aaiaoe/ieo oa na?aaeiaeuieo oaeoi??a o oi?ioaaii? ini??aco a oa?e?anuee?e iiioeyoe?? // Iaoa??ae? ?? c’?caeo iaaee/ieo aaiaoee?a Oe?a?ie. – Euea?a. – 1995. – n. 145. Oaaeioa I.I. Aaiaoe/ia aeine?aeaeaiiy ini??aco. – ?oeiien. Aeena?oaoe?y o aeaeyae? ?oeiieno ia caeiaoooy iaoeiaiai nooiaith eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 03.00.15 – aaiaoeea, Oa?e?anueeee aea?aeaaiee oi?aa?neoao, Oa?e?a, 1998. Iniiaiee ci?no aeeeaaeaii a 7 iaoeiaeo i?aoeyo, ye? i?noyoue aeine?aeaeaiiy iniaeeainoae oniaaeeoaaiiy ini??aco. ?icaeyiooi 400 ?iaeiaiae?a oai?eo ia ini??ac. I?iaaaeai? naa?aaaoe?eiee, eiiiiiaioiee oa aeaiia?ao?/iee aiae?c ini??aco. Oniaaeeiaai?noue a ?aieao eaaceaacia?a?aii? iiaeae? – Ga = 0,731, Gt = 1. Ioe?iee ia?aiao??a iiiiaaiii? iiaeae? c iaiiaiith iaiao?aioi?noth oae?: ? = 0,038, I1 = 7,2%, I2 = 89,1%. Iieacaia aeniea ?iciianthaeaeai?noue ini??aco a i?ai?/ieo iaeeo ?anao ?a?iiai?aeii? aaeeei? ?ane, iecueea – aeey iaa?i?aeieo aoi?/ieo a?oi. A?aei?/a?oueny cieaeaiiy ?iciianthaeaeaiino? ini??aco a?ae i?ai?/iiai iiethna aei aeaaoi?a aeey iaeeo oa aaeeeeo ?an. Ia ciaeaeaii ??cieoe? a ?iciianthaeaeaiino? ini??aco i?ae i?nueeeie oa n?euenueeeie iiioeyoe?yi?. Eeth/ia? neiaa: aaiaoeea, ini??ac, ?iciianthaeaeai?noue, iiaeaeue oniaaeeoaaiiy, iiioeyoe?y. Oaaeioa A. I. Aaiaoe/aneia enneaaeiaaiea ini?eaca. – ?oeiienue. Aeenna?oaoeey a aeaea ?oeiiene ia nieneaiea iao/iie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 03.00. 15 – aaiaoeea, Oa?ueeianeee ainoaea?noaaiiue oieaa?neoao, Oa?ueeia, 1998. Iniiaiia niaea?aeaiea eceiaeaii a 7 iao/iuo ?aaioao, eioi?ua niaea?aeao enneaaeiaaiea iniaaiiinoae ianeaaeiaaiey ini?eaca. ?anniio?aii 400 ?iaeineiaiuo aieueiuo ini?eacii. I?iaaaeaiu naa?aaaoeeiiiue, eiiiiiaioiue e aeaiia?aoe/aneee aiaeec ini?eaca. Ianeaaeoaiinoue a ?aieao eaaceiai?a?uaiie iiaeaee – Ga = 0.731, Gt=1. Ioeaiee ia?aiao?ia iiiiaaiiie iiaeaee n iaiieiie iaiao?aioiinoueth oaeea: ? = 0.038, I1 = 7.2%, I2 = 89.1%. Iieacaia aunieay ?ani?ino?aiaiiinoue ini?eaca a naaa?iuo iaeuo ?anao ?a?iiaieaeiie aieueoie ?anu, ieceay – aeey iaa?ieaeiuo yoie/aneeo a?oii. Ioia/aaony nieaeaiea ?ani?ino?aiaiiinoe ini?eaca io naaa?iiai iiethna e yeaaoi?o aeey iaeuo e aieueoeo ?an. Ia iaeaeaii ?acieoeu a ?ani?ino?aiaiiinoe ini?eaca iaaeaeo ai?iaeneeie e naeueneeie iiioeyoeeyie. Eeth/aaua neiaa: aaiaoeea, ini?eac, ?ani?ino?aiaiiinoue, iiaeaeue ianeaaeiaaiey, iiioeyoeey. Fedota A.M. Genetic investigation of psoriasis. – Manuscript. A thesis for a biology candidate degree in the speciality 03.00.15 – genetics. Kharkov State University, Kharkov, 1998. Maintained are 7 papers dealing with peculiarities of inheritance of psoriasis. The pedigrees of 400 patients suffering from psoriasis have been investigated. The segregation, component and demographic analisys were carried out. In the terms of the quasiunbroken model heritability Ga is equal to 0,7310. Estimates of parametres of the monogenic model with incomplete penetrance are: p = 6,038, P1 = 7,2%, P2 = 89,1%. The high frequency of psoriasis has shown in north little races of large european race and the low frequency – in negro ethnic groups. It has found out that frequency of psoriasis is decreasing from Noth Pole to Equator in little and large races. The frequancy of psoriasis is’nt various in towns and villages populations. Key words: genetics, psoriasis, frequency, model of inheritance, population.

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