12

I?I?NOA?NOAI IOI?IIE CAeI?IAss OE?A?IE

E?EINUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

?i. N.?. AAI?A??ANUeEIAI

OAeE 616.12+616.611-002-61.002.3-089

AAN?EAN Eiinoaio?iin

OOIEOe?IIAEUeI? CI?IE NA?OeAAI-NOAeEIII? NENOAIE O OAI?EO IA
AEIIA?OEIIAO?EO ? I??EIIAO?EO, ssE? IA?AAOAATHOUe IA I?IA?AIIIIO
AAIIAe?AE?C?, OA OEssOE ?O EI?AEOe??

14.01.02- aioo??oi? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

N?ioa?iiieue 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiia a E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
N.?. Aai?a??anueeiai.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

E?oo?eia Na?a?e Ieeieaeiae/, E?einueeee aea?aeaaiee iaaee/iee
oi?aa?neoao ?i. N.?. Aai?a??anueeiai, caa?aeoaa/ eaoaae?e i?iiaaeaaoeee
aioo??oi?o oai?ia

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Nae?aaiiaa Enai?y Oaaei??aia, E?einueeee aea?aeaaiee iaaee/iee
oi?aa?neoao ?i. N. ?. Aai?a??anueeiai, eaoaae?a oaeoeueoaonueei? oa?ai??
?1

aeieoi? iaaee/ieo iaoe, i?ioani?

Nai?aeioeueea AEaiia Aeieo??aia, Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, caa?aeoaa/ eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia

I?ia?aeia i?aai?caoe?y:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey.

Caoeno a?aeaoaeaoueny “16” eenoiiaaea 1999 ?ieo i 14aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 52.600.01 i?e E?einueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i. N.?. Aai?a??anueeiai (333006,
i. N?ioa?iiieue, aoe. Eai?ia 5/7)

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?. Aai?a??anueeiai (333006,
i. N?ioa?iiieue, aoe. Eai?ia, 5/7).

Aaoi?aoa?ao ?ic?neaiee “9” aeiaoiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, aeieoi? iaaee/ieo iaoe ,

i?ioani? I.O.
Iaco?aoeue

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. O?ii?/ia ie?eiaa iaaeinoaoi?noue (OII) ?
iane?aeeii aaaaoueio caoai?thaaiue ie?ie [N.E. ?yaia, 1997]. *anoi
a?aei?/a?oueny ?icaeoie OII a in?a iieiaeiai a?eo, ui ? i?e/eiith
?iaae?aeecaoe?? ? nia?o? oai?eo. I?e oeueiio, yeui i?e e?eoaaii? oai?iae
ie?ie oni?oe aeoaea ne?iii?, oi a oa?ai?? ie?eiai? iaaeinoaoiino?
a?aei?/ai? a?eueo? aeinyaiaiiy. Oa?ai?y OII ?iciiae?ey?oueny ia o?e
aaeee? aoaie eiina?aaoeaiee, aeoeaiee ? o??o?a?/iee aai
o?ainieaioaoe?eiee.

Iaea?eueoa iioe?aiiy o na?o? io?eiaea ae?ae?cia oa?ai?y. Noai
na?oeaainoaeeiii? nenoaie aecia/a? i?iaiic oa iane?aeee e?eoaaiiy
a?eueoa i?ae o iieiaeie oai?eo, ye? ia?aaoaathoue ia e?eoaaii?
i?ia?aiiei aaiiae?ae?cii, a oaeiae a cia/iiio nooiai? aeaeeaaiiy
?aoe?i??io?a ie?eiaiai o?ainieaioaoo, iniaeeai o aeiaaeeo ia?anaaeee
ie?ee iaoe??ioai c ae?aaaoe/iith iao?iiao??th [N.E. ?yaia, TH.E.
Iaoi/ei, 1997].

Oaeoi?aie, ui coiiaeththoue /anoioo oneeaaeiaiue c aieo
na?oeaainoaeeiii? nenoaie, ? a?ia?oaic?y, ii?ooaiiy aeaeo?ie?oiiai ?
aiaeiiai aaeaino c ?aaoey?iith a?ia?a?ae?aoaoe??th oa aaeaioeaieie
eieeaaiiyie ?ici???a na?oey, iaoaaie?cio e?i?ae?a oa aoaeaaiae?a, ye?
aeeeeeathoue i?enei?aiee ?icaeoie aoa?ineea?ico, iayai?noue o oai?eo
aiai?? ? iino?eiiai ?icaeoeo ia?eea?aeo ? o.ae. [GEHC,1988]. Iacaeaaeiei
oaeoi?ii ?eceeo, ye a caaaeuei?e iiioeyoe??, oae ? o oai?eo ia
aaiiae?ae?c?, aaaaea?oueny oaeiae a?ia?o?io?y e?aiai oeoii/ea, a
?icaeoeo yeiai aiinyoue aianie aiai?y ? a?ia?oaic?y [I.N. Aaeionia e
niaao., 1988; I.I. Aeaaeeie?iaa e niaao., 1990; Sothern R.B. et al.,
1995; Wollert K.C. et al., 1994].

I?i iiaeeeaee caycie iaoieia?? ie?ie c i?aeaeuaiiyi a?oa??aeueiiai oeneo
iiaeia caeeth/eoe ua ?c ia?oiai iia?aeiieaiiy Bright (1836), a yeiio
aeacoaaeiny ia a?ia?o?io?th na?oey aac ci?i noaeei. A?eueo /?oei oea
ieoaiiy ?ic?iaeaia o i?aoeyo F.Volhard et Th Fahr (1914), ye? aeae?eeee
noaeeii? o?aaeaiiy ie?ie a ie?aio ?oa?eeo. Oaea a inoaii? 50 60 ?ie?a
aoea /?oei noi?iiaaia eiioeaioe?y i?i ?ieue ie?ie o iaoiaaiac?
a?oa??aeueii? a?ia?oii??, yea i?ecia? ca ie?eith ye i?ani?io, oae ?
aeai?ani?io ooieoe?th.

Ia nueiaiaeiyoi?e aeaiue iaea?eueoee ?ioa?an i?aaenoaaey? caycie i?ae
?ai?i-aia?ioaicei-aeueaeinoa?iiiaith nenoaiith (?AAN) ? a?ieia?/ieie
aeoeaieie ?a/iaeiaie, ye? aeae?eythoueny ?c ia?aaena?aey oae iaceaa?ieo
ao??iiaioeae?a. Iaeei ?c oeeo iaioeae?a oea iao??eo?aoe/iee iaioeae
(IOI) 28-ai?ii-eeneioiee iaioeae, yeee i?noeoueny a a?aioeao i?ioeeo?a
ia?aaena?aey o aeaeyae? i?iai?iiio [Fontana F. et al., 1997]. IOI
i?aaenoaaey? niaith iiaooi?e iao??eo?aoe/iee ? noaeeiii?icoe?thth/ee
aaaio, a oaeiae ? ?ia?a?oi?ii i?iaeoeoe?? aeueaeinoa?iio [Schenk G. et
al., 1985].

Ii?ooaiiy e?i?aeiiai iai?io aeyaeythoue iaeaea o 100% oai?eo c OII.
A?eueo?noue aeine?aeiee?a aaaaeathoue, ui o?ai?/ia aeene?iii?ioa?aeai?y
ni?ey? i?enei?aiiio ?icaeoeo aoa?ineea?ico, yeee eaaeeoue a iniia?
aeieeiaiiy eaoaeueieo na?oeaai noaeeiieo oneeaaeiaiue o oai?eo ia
aaiiae?ae?c? [Handbook of dialysis, 1988; Valek A., 1989].

?c aeuaaeeeaaeiaiiai aeo?ea? aeooaeuei?noue caaea/?, yea iieyaa? a
oiio, ui ieoaiiy i?iaaaeaiiy aaiiae?ae?co ? ei?aeoe?y oneeaaeiaiue, yea
aeieea? i?ae /an naaino aaiiae?ae?co, iio?aaothoue iiaeaeueoiai
aea/aiiy.

Iaoa aeaiiai aeine?aeaeaiiy: aeyaeaiiy iiaeo caeiiii??iinoae aeayeeo
iieaciee?a ooieoe?iiaeueiiai noaio na?oeaainoaeeiii? nenoaie a ie?aieo
a?oi oai?eo, ye? ia?aaoaathoue ia i?ia?aiiiio aaiiae?ae?c?, ? ?ic?iaeoe
niiniae ei?aeoe?? ?o ci?i.

Aeey ?aae?caoe?? aeaii? iaoe iaie iinoaaeai? oae? iniiai? caaea/?:

1. aea/eoe ai?iiiaeueio ooieoe?th na?oey ia iniia? aeae?eaiiy
iao??eo?aoe/iiai iaioeaeo a oiiaao i?iaaaeaiiy aaiiae?ae?co ? i?ae
aieeaii e?ea?nueeeo i?aia?ao?a;

2. aeaoe ioe?ieo ci?i ?ai?i aia?ioaiceiiiai? nenoaie i?ae /an
aaiiae?ae?co ? a i?aeae?ae?ciiio ia??iae?, oa i?e canoinoaaii?
e?ea?nueeeo ?a/iaei ?c ??cieo a?oi;

3. ooi/ieoe aca?iicaycie ?ai?iaia?ioaiceiaeueaeinoa?iiiai? nenoaie oa
iao??eo?aoe/iiai iaioeaeo o oai?eo ia i?ioyc? ?o e?eoaaiiy ia
i?ia?aiiiio aaiiae?ae?c?;

4. aea/eoe ii?oieia?/i? iniaeeaino? ea?ae?ioeeo?a o oai?eo ia aoi?eiio
a?ia?oii?th oa a?oa??aeueio a?ia?oii?th iaie?eiaiai aaiaco;

5. ooi/ieoe aieea aaiiae?ae?co ia oeaio?aeueio ? ia?eoa?e/io
aaiiaeeiai?eo ia i?aenoaa? ci?i ia?oe?aeueiiai oeneo eenith, ci?i
iieaciee?a ?aia?aie oa oeueo?acaoeiaiai aeine?aeaeaiiy na?oey.

Iaoeiaa iiaecia aeine?aeaeaiue caeeth/a?oueny a oiio, ui iaea?aeai? iia?
aeai? i?i a?aei?iiino? noaio ?ai?iaia?ioaiceiaeueaeinoa?iiiai? nenoaie o
oai?eo ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo, ye? ia?aaoaathoue ia
i?ia?aiiiio aaiiae?ae?c?. Iieacai? ??ci? noaie ea?ae?ioeeo?a o oai?eo,
ui no?aaeaeathoue anaioe?aeueiith oa aoi?eiiith , ie?eiaiai aaiaco,
a?oa??aeueiith a?ia?oaic??th. Oae? iniaeeaino? i?ioeaaeo?e aaiiae?ae?co,
ye cieaeaiiy ia?oe?aeueiiai oeneo eenith, oi?ioaaiiy aaiiciiai canoith,
ni?ey? oi?ioaaiith na?oeaai? iaaeinoaoiino?, oeaieiii? ? ee?oeiii?
a?iien??. ?acii c oeeie ci?iaie aeyaeaii i?aeaeuaiiy ooieoe??
ueoiaeaeii? caeice o oai?eo ie?eiaith iaoieia??th c o?ii?/iith ie?eiaith
iaaeinoaoi?noth a oa?i?iaeuei?e noaae??. Iieacaia ?aoe?iiaeuei?noue
a?iioaiceaii? oa?ai?? c iaoith noaa?e?caoe?? oa eiio?iethaaiiy
a?oa??aeueiiai oeneo i?ae /an i?ioeaaeo?e aaiiae?ae?co ? a
i?aeae?ae?ciiio ia??iae?.

I?aeoe/ia cia/aiiy ?acoeueoao?a aeine?aeaeaiiy. Aeyaeai? a?aei?iiino?
noaio ?ai?iaia?ioaiceiaeueaeinoa?iiiai? nenoaie oa iao??eo?aoe/iiai
iaioeaeo o oai?eo ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo a
oa?i?iaeuei?e noaae?? ie?eiai? iaaeinoaoiino? aeicaieeee ei?aeooaaoe
ia?aiao?e i?iaaaeaiiy naaino aaiiae?ae?co o oeeo oai?eo. A?aeiiaeaiiy
aaeaeaaoii? a?iioaiceaii? oa?ai?? o aeaeyae? ?iaeea?aeoaeueiiai aeai?o
e?ea?nueeeo i?aia?ao?a ?c a?oi ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai
oa?iaioo ? naeaeoeaieo 1aae?aiiaeieaoi??a, iie?ioo? naain aaiiae?ae?co
oa oiia?eueith? i?ia?anoaaiiy ie?eiai? ? na?oeaai? iaaeinoaoiino?.
Onoaiiaeaia iaiao?aei?noue canoinoaaiiy aioeieneaeaioii? oa?ai?? c
iaoith aeaoieneeaoe?? ? i?aeaeuaiiy /ooeeaino? i?aai?cio oai?iai aei
ae?? noa?i?aeieo i?aia?ao?a oa iiaeiaaeaiiy no?ie?a ?ai?n??.

Iniaenoa o/anoue aaoi?a a ?ic?iaoe? iniiaieo iieiaeaiue aeena?oaoe??.
?iaioa aeeiiaia ia eaoaae?? i?iiaaeaaoeee aioo??oi?o oai?ia E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?. Aai?a??anueeiai
(caa?aeoaa/ aeieoi? iaaee/ieo iaoe, i?ioani? N.I. E?oo?eia) ia aac? ? ?
?? oa?aiaaoe/ieo ? ea?ae?ieia?/iiio a?aeae?eaiiyo 7-i? i?nueei? e?ea?i?
oa o a?aeae?eaii? o?ii?/iiai aaiiae?ae?co ?EE ?i. I.I. Naiaoea.

Ianoaaeaiiy oai?eo ?c canoinoaaiiyi iniiaieo iaoiae?a aeine?aeaeaiiy,
noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiiy oa ?o aiae?c, iaienaiiy
?iaioe aeeiiai? aaoi?ii naiino?eii.

?acoeueoaoe ?iaioe ai?iaaaeaeai? a i?aeoeeo o a?aeae?eaii? o?ii?/iiai
aaiiae?ae?co ?EE ?i. I.I. Naiaoea.

Ai?iaaoe?y iaoa??ae?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiiy
aeiiia?aeaeeny oa iaaiai?thaaeeny ia can?aeaii? E?einueeiai iaoeiaiai
oiaa?enoaa oa?aiaao?a (1998, 1999).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 4 iaoeia? i?aoe?
oa iaeia ?aoe?iiae?caoi?nueea i?iiiceoe?y.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny c? anooio,
iaeyaeo e?oa?aoo?e, ?icae?eo “Iaoiaee aeine?aeaeaiiy ? ee?i?/ia
oa?aeoa?enoeea oai?eo”, ?icae?eo ?c iyoe i?ae?icae?e?a, a yeiio
iaaaaeai? ?acoeueoaoe aieeao aaiiae?ae?co ia noai na?oeaai noaeeiii?
nenoaie, ?icae?eo ?c aeaio i?ae?icae?e?a, a yeiio iaaaaeai? ?acoeueoaoe
aieeao e?ea?nueeeo i?aia?ao?a ia ?ai?iaia?ioaiceiio nenoaio oa
iao??eo?aoe/iee iaioeae, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo e?oa?aoo?e, yeee aeeth/a? 228 aeaea?ae.
Aeena?oaoe?y aeeeaaeaia ia 104 noi??ieao (aac iieaae/eea e?oa?aoo?e),
?ethno?iaaia 30 ?enoieaie, 12 oaaeeoeyie.

CI?NO AeINE?AeAEAIIss

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. Aeey aeinyaiaiiy aeaii? iaoe ?
iinoaaeaieo caaea/ aoei ianoaaeaii 25 i?aeoe/ii caei?iaeo ethaeae, 20
oai?eo ia a?ia?oii?/io oai?iao ?? noaae?? (AO), 20 oai?eo a?ia?oii?/iith
oi?iith o?ii?/iiai aeiia?oeiiao?eoo (OAI) aac o?ii?/ii? ie?eiai?
iaaeinoaoiino?, 20 oai?eo a?ia?oii?/iith oi?iith o?ii?/iiai i??eiiao?eoo
(O?II) aac o?ii?/ii? ie?eiai? iaaeinoaoiino?, 33 oai?eo ia o?ii?/iee
aeiia?oeiiao?eo c o?ii?/iith ie?eiaith iaaeinoaoi?noth (OII) ??A???A
noaae?? ? 22 oai?eo ia o?ii?/iee i??eiiao?eo c o?ii?/iith ie?eiaith
iaaeinoaoi?noth ??A???A noaae??. Aeey aecia/aiiy oi?ie aeiia?oeiiao?eoo
? i??eiiao?eoo oa noaae?? o?ii?/ii? ie?eiai? iaaeinoaoiino?
aeei?enoiaoaaeany eeaneo?eaoe?y N.?. ?yaiaa. On? oai?? c o?ii?/iith
ie?eiaith iaaeinoaoi?noth ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?.

?aae?i?ioiiei niiniaii aecia/aeeny o oai?eo eiioeaio?aoe?y
aeueaeinoa?iio (Aeueae), aia?ioaiceio ? (Aia ?), aeoeai?noue ?ai?io
ieacie (A?I) iao??eo?aoe/iiai iaioeaeo (IOI), ai?iii?a ueoiaeaeii?
caeice O3 ? O4.

Oai?ei ia aaiiae?ae?c? ia ii/aoeo ? a e?ioe? naaino aecia/aeeny
eiioeaio?aoe?? iao??th, eae?th, na/iaeie ? e?aaoei?io.

On?i oai?ei ia i?ia?aiiiio aaiiae?ae?c? i?iaiaeeeany aoiea?ae?ia?ao?y.

Ia i?aenoaa? iaea?aeaieo aaciaeo oa?aeoa?enoee aecia/aeeny ?ic?aooieia?
?iaeaene: e?ioeaaiae?anoie?/iiai ia?io e?aiai oeoii/ea (?EAeI), ?iaeaen
e?ioeaaiai nenoie?/iiai ia?io e?aiai oeoii/ea (?ENI), ?iaeaen iane
i?iea?aea e?aiai oeoii/ea (?IIEO).

E??i aoiea?ae?ia?ao?? aecia/aeeny ?aia?ao?/iee ?iaeaen, a?aeiioaiiy
ae?anoie?/ii? aei nenoie?/ii? oaee?, yea a?aeia?aaea? ni?aa?aeiioaiiy
a?oa??aeueiiai ? aaiiciiai e?iaioieo, a?aeiioaiiy, yea oa?aeoa?eco?
aaee/eio ia?eoa?e/iiai iii?o; iaeneiaeueia oaeaee?noue e?iaaiaiiaiaiiy,
yea oa?aeoa?eco? noai nei?ioeeai? ooieoe?? i?iea?aea, oaeaee?noue
e?iaaiaiiaiaiiy e?oiieo a?eie a?oa??e.

Uia ioe?ieoe nooiai? iane/aiiy e?ia? eeniai, ie aecia/aee ia?oe?aeueiee
oene eenith a ia?eoa?e/i?e e?ia? ia ieneaaiiiao?? o??ie
“Radiometer”Aeai?y.

On?i oai?ei c o?ii?/iith ie?eiaith iaaeinoaoi?noth (OII) aaeany
ae?ae?cia ea?oi/ea. Aei naaino aaiiae?ae?co o?enoaaeany ii/aoeiaa aaaa.
I?ae /an i?iaaaeaiiy aaiiae?ae?co o?enoaaeeny oeeo?e nenoie?/iiai ?
ae?anoie?/iiai a?oa??aeueiiai oeneo, ioeuen eiaei? 30 ? i?aia?aoe, ye?
aaiaeeeeny i?ae /an i?ioeaaeo?e. I?ney naaino a?aei?/aeany e?ioeaaa
aaaa oai?iai.

I?e ia?iaoe? iaea?aeaieo ?acoeueoao?a aoee canoiniaai? iaoiaee
aa??aoe?eii? noaoenoeee c aecia/aiiyi ??aiy cia/ouino? a?aei?iiinoae ca
e?eoa???i Wilcoxon ? aeinoia??iino? a?aei?iiinoae (?), aa?o/e ca
aeinoia??iee ??aaiue cia/aiiy, ii/eiath/e c ?<0,05. I?iaaaeaiee ei?aeyoe?eiee aiae?c. ?acoeueoaoe aeine?aeaeaiiy ? aeniiaee. Ia i?aenoaa? aeeiai?ee a?oa??aeueiiai oeneo ie ?iciiae?eeee a?oie ae?ae?cieo oai?eo ia aea? i?aea?oie: aei ia?oi? i?aea?oie a?aeiineeeny oai??, o yeeo na?aaei?e a?oa??aeueiee oene i?aeaeuoaaany a e?ioe? aaiiae?ae?co; a ae?oao i?aea?oio aoiaeeee oai??, o yeeo na?aaei?e a?oa??aeueiee oene cieaeoaaany a e?ioe? aaiiae?ae?co. Aeeiai?ea na?aaeiueiai a?oa??aeueiiai oeneo aeey ia?oi? i?aea?oie oai?eo ia OAI ? O?II oa?aeoa?ecoaaeany noaa?eueiei, iinooiiaei ca?eueoaiiyi. Aaaeeeai a?aei?oeoe, ui i?e oeueiio na?aaei?e a?oa??aeueiee oene o e?ioe? aaiiae?ae?co o oai?eo ia O?II aeyaeany cia/ii aeuei, i?ae na?aaei?e a?oa??aeueiee oene o oai?eo ia OAI ia?oi? i?aea?oie. A ae?oaeo i?aea?oiao na?aaei?e a?oa??aeueiee oene oa?aeoa?ecoaaany o?aiaoe??- iiae?aiei ia?aa?aii, i?aeaeuoaaany ia ii/aoeo aaiiae?ae?co, c ia?oi? ii o?aoth aiaeeio naaino noaa?e?coaaany ia iaeiiio ??ai?, a i?ae e?iaoeue aaiiae?ae?co nioneaany ieae/a aeo?aeiiai ??aiy. Aeeiai?ea na?aaeiueiai a?oa??aeueiiai oeneo i?ae /an aaiiae?ae?co neeueii iiaycaia c? ci?iaie eiioeaio?aoe?? ?ai?iaia?ioaiceiaeueaeinoa?iiiai? nenoaie, iao??eo?aoe/iiai iaioeaeo oa ?ii?a e?ia?. A na?aaeiueiio, aeoeai?noue ?ai?io ieacie o oai?eo ia OAI aeua, i?ae o oai?eo ia O?II. Iaaeeaey/enue ia oea, ai?no aia?ioaiceio ? o oai?eo ia O?II cia/ii ia?aaeuo? ai?no ai?iiio o oai?eo ia OAI. E??i oiai, i?aeaeuaiiy A?I, yea a?aeaoaa?oueny i?ae /an aaiiae?ae?co, iniaeeai a ia?oeo i?aea?oiao oai?eo, i?eaiaeeoue aei iaeiie/aiiy Aia ? c ianooiiei ca?eueoaiiyi eiai eiioeaio?aoe?? a e?ioe? aaiiae?ae?co (aeea. oaae.1). I?iaaaeaiiy ei?aeyoe?eiiai cayceo i?ae ci?iaie eiioeaio?aoe?? Aia ? oa ci?iaie na?aaeiueiai a?oa??aeueiiai oeneo aeicaieeei aeyaeoe iayai?noue i?yiiai cayceo a ia?oeo i?aea?oiao oa cai?ioiiai cayceo a ae?oaeo i?aea?oiao (aeea. oaae.2). Ci?ie na?aaeiueiai a?oa??aeueiiai oeneo i?yii ei?aeththoue c? ci?iaie A?I a iaio a?oiao oai?eo. Ei?aeyoe?eiee aie?c ia aeyaea ?nioth/iai cayceo i?ae ci?iaie eiioeaio?aoe?? ?ii?a oa Aia ? o oai?eo ia OAI. ?ioa ea?oeia niinoa??aaeany i?e i?iaaaeaii? ei?aeyoe?eiiai cayceo i?ae ?iiaie oa Aia ? o oai?eo ia O?II. Aeey oai?eo ia?oi? i?aea?oie ci?ie eiioeaio?aoe?? Aia ? neeueii ei?aeththoue c? ci?iaie eiioeaio?aoe?? iao??th ? aeniei c eiioeaio?aoe??th eae?th. Aeey ae?oai? i?aea?oie ?nio? aenieee ei?aeyoe?eiee caycie ?c ci?iaie eiioeaio?aoe?? eae?th. Iniaeeao oaaao caneoaiao? aeeiai?ea eiioeaio?aoe?? aeueaeinoa?iio. Ia aeoieo I.?. Iaeia?ea (1988), eiioeaio?aoe?y aeueaeinoa?iio iiaeiia ciaiooaaoeny i?ae e?iaoeue naaino aaiiae?ae?co, oae ye iaia?aia ae?ae?caoi?a ? i?iieeeeaith aeey iueiai. Aecia/aiiy ei?aeyoe?eiiai cayceo iieacaei, ui i?ae aeueaeinoa?iiii ? na?aaei?i a?oa??aeueiei oeneii ?nio? i?yiee caycie. Aaeeeee ?ioa?an ia? caycie aeueaeinoa?iiio c aia?ioaiceiii ?. Aeey aaiiae?ae?co ?nio? i?yiee, neeueiee caycie i?ae oeeie ai?iiiaie aeey oai?eo iaio a?oi. I?ney aaiiae?ae?co a?i ii?ooo?oueny, noa? cai?ioiei, neaaeei aeey oai?eo ia OAI ? neeueiei aeey oai?eo ia O?II. Ne?ae a?aei?oeoe, ui eiioeaio?aoe?y aeueaeinoa?iio o oai?eo ia O?II cia/ii aeua ii?ie (5 ?ac?a) ? eiioeaio?aoe?? aeueaeinoa?iio o oai?eo ia OAI (2 ?ace) (aeea. oaae.1). Uia aeeeth/eoe aeieeiaiiy aeniaaeaiiy ooieoe?iiaeueieo cae?aiinoae ei?e iaaeie?eiai? caeice, ie aeine?aeaeoaaee ai?no aeueaeinoa?iiio o oeeo a?oi oai?eo i?ney 10 ? 25 naain?a. Aeinoia??i? ci?ie ai?noo aeueaeinoa?iiio ie io?eiaee o?eueee i?ney 25 naain?a. O a?oiao c i?aeaeuaiiyi a?oa??aeueiiai oeneo ie io?eioaaee aeo?aeia ca?eueoaiiy ??aiy aeueaeinoa?iio aeey oai?eo ia OAI ia 10,3 ? 25,8 ia/ie (?<0,05) ? aeey oai?eo ia O?II ia 31,8 ? 55,2 ia/ie (?<0,05). O a?oiao c? cieaeaiiyi a?oa??aeueiiai oeneo io?eiaee aeey a?oie OAI ciaioaiiy ai?iiio ia 15,5 ia/ie (?<0,05), ? a a?oi? O?II ia 8,9 ia/ie (?<0,05). Oae? ?acoeueoaoe aeacothoue ia oa, ui o oai?eo c oaiaeaioe??th aei i?aeaeuaiiy a?oa??aeueiiai oeneo i?ae /an aaiiae?ae?co oi?io?oueny aeueaeinoa?ii?ci, oiae? ye o oai?eo c oaiaeaioe??th aei ciaioaiiy a?oa??aeueiiai oeneo i?ae /an aaiiae?ae?co aeo?aeia eiioeaio?aoe?y aeueaeinoa?iiio ciaioo?oueny. Ie niinoa??aaee ciaioaiiy eiioeaio?aoe?? IOI a iaio a?oiao aei ii?iaeueiiai aeey iueiai ??aiy. Iiaa?iaiiy eiioeaio?aoe?? IOI aei ii?iaeueiiai aeey iueiai ??aiy i?ney aaiiae?ae?co ? ?acoeueoaoii aca?iiae?? o?ueio oaeoi??a. Iiia?oa, ciaioaiiy ai?noo aeueaeinoa?iio ? iao??th aeeeeea? cieaeaiiy eiioeaio?aoe?? IOI. Iiae?oaa, /anoeia IOI iiaeiia caaoaeoeny /a?ac iaia?aio ae?ae?caoi?a, ia ui aeaco? oie oaeo, ui a i?aea?oiao, iaaeeaey/enue ia i?aeaeuaiiy aai cieaeaiiy na?aaeiueiai a?oa??aeueiiai oeneo, ciaioaiiy eiioeaio?aoe?? IOI iaeiaeiaa. Iio?ao?, i?e i?iaaaeaii? aaiiae?ae?co a?aeaoaa?oueny ciaioaiiy ia?io oee?eoethth/i? e?ia?, ui i?ecaiaeeoue aei ?aoeaeoi?iiai ciaioaiiy ai?noo IOI. I?ae /an aaiiae?ae?co ei?aeyoe?eiee caycie i?ae IOI oa aeueaei- noa?iiii caeeoa?oueny i?yiee ? noaa?eueiee. A?eueoa oiai, a ii?i? ni?aa?aeiioaiiy eiioeaio?aoe?? i?ae aeueaeinoa?iiii ? IOI neeaaea? iaeeieoe?. Aei aaiiae?ae?co aeey oai?eo ia OAI c i?aeaeuaiiyi na?aaeiueiai a?oa??aeueiiai oeneo ni?aa?aeiioaiiy aoei 0,52 ? aeey oai?eo c? cieaeaiiyi eiai 0,46 a a?e aeueaeinoa?iio. I?ney aaiiae?ae?co aeey oai?eo ia?oi? i?aea?oie i?aeoe/ii ia ci?ieeiny ? noaei 0,59 a a?e aeueaeinoa?iio, aea aeey oai?eo ae?oai? i?aea?oie ni?aa?aeiioaiiy c?inei ? noaei 0,99. Ni?aa?aeiioaiiy ai?iii?a o oai?eo ia O?II aei aaiiae?ae?co aeey oai?eo ia?oi? i?aea?oie neeaei 0,29, a aeey ae?oai? 0,87. I?ney aaiiae?ae?co aeey oai?eo ia?oi? i?aea?oie ni?aa?aeiioaiiy 0,42 i?iaeiaaeoaaei iaoe ia?aaaao a a?e aeueaeinoa?iio, a aeey ae?oai? i?aea?oie, na?aaei?e a?oa??aeueiee oene yeeo cieaeoaaany, ia e?iaoeue aaiiae?ae?co ni?aa?aeiioaiiy noaei a?eueoa a a?e IOI ? neeaei 1,15. Aaaeeeai a?aei?oeoe, ui ca?eueoaiiy aeoeaiino? ?ai?io a?aeaoaa?oueny a oeo a?oiao, aea ni?aa?aeiioaiiy aeueaeinoa?iio ? IOI ia ei?enoue ia?oiai. Eiee ?o ni?aa?aeiioaiiy aeeae/a aei iaeeieoe? (ye ? a ii?i?), aeoeai?noue ?ai?io caeeoa?oueny noaa?eueiith. Ioaea, cieaeaiiy a?oa??aeueiiai oeneo a aaiiae?ae?c? a?aeaoaa?oueny a oeo aeiaaeeao, eiee ni?aa?aeiioaiiy aeueaeinoa?iiio ? IOI aeeae/a aei iaeeieoe?. I?e aea/aii? oao?aiiey?ii? ?aia?ao??, oeueo?acaoeiaiai aeine?aeaeaiiy oa aei??o ia?oe?aeueiiai oeneo eenith iai aaeaeiny aeyaeoe iniaeeaino? aaiiaeeiai?ee o oai?eo aei ? i?ney aaiiae?ae?co, ?, cie?aia, i?ae oai?eie ia OAI ? O?II. I?ney aaiiae?ae?co niinoa??aa?oueny ??no on?o iieaciee?a ?aia?aie. Nei?ioeeaa cae?ai?noue i?iea?aea (yea oa?aeoa?eco?oueny aaee/eiith V iaen) i?ney aaiiae?ae?co aeey oai?eo ia O?II ca?eueoo?oueny ia 41,1%, eiee aeey oai?eo ia OAI caeeoa?oueny i?aeoe/ii ia ci?iaiith. Iaeii/anii a?aeaoaa?oueny ca?eueoaiiy /ano oaeaeeiai e?iaaiaiiaiaiiy () o oai?eo ia OAI ia 59,6% ? o oai?eo ia O?II ia 33,9%. I?e oeueiio a iaio a?oiao oai?eo ia?eoa?e/iee ii?? (O) i?ney aaiiae?ae?co ca?eueoo?oueny. O oai?eo ia OAI a?aeaoaa?oueny ca?eueoaiiy O ia 7,71% ? o oai?eo ia O?II ia 6,27%. E??i oiai, i?ney aaiiae?ae?co niinoa??aa?oueny ca?eueoaiiy ni?aa?aeiioaiiy a?oa??aeueiiai aei aaiiciiai e?iaioieo (D), o oai?eo ia OAI ca?eueoeeiny ia 9,7% ? aeey oai?eo ia O?II ia 7,8% ia ei?enoue inoaiiueiai, yea noi?iaiaeaeo?oueny a?ae ca?eueoaiiy ioeueniaiai e?iaiiaiiaiaiiy na?oey (??) ia 21,2% o oai?eo ia OAI ? ia 33,5% o oai?eo ia O?II. I?e i?iaaaeaii? oeueo?acaoeiaiai aiae?co o 50 (90,9%) oai?eo aeyaeaia a?ia?o?io?y e?aiai oeoii/ea. I?ney aaiiae?ae?co a?aeaoaa?oueny ca?eueoaiiy e?ioeaaiae?anoie?/iiai ?ici??o (EAe?) ia 0,48 ii (?<0,05) e?ioeaaiae?anoie?/iiai ia?io (EAeI) ia 25,87 ii3 (?<0,01) e?aiai oeoii/ea. O?aeoe?y aeeeaeo ca?eueooaaeany ia 18,82% (?<0,01). Ii?o/ c? ci?iaie oeeo iieaciee?a ie io?eiaee aeinoia??ia ca?eueoaiiy iieaciee?a ?iaeaen?a ?EAeI ia 13,81 (?<0,05) , ?IIEO ia 24,22 (?<0,01). I?ney aaiiae?ae?co a?aeaoaa?oueny ciaioaiiy aaae oai?iai o aeaeyae? ao?aoe ??aeeie, a ?acoeueoao? /iai i?ney aaiiae?ae?co ca?eueoothoueny ?iaeaene ?EAeI, ?ENI oa ?IIEO. Aaaeeeai a?aei?oeoe ca?eueoaiiy o?aeoe?? aeeeaeo i?ney aaiiae?ae?co a?aeaoaa?oueny a ?acoeueoao? i?aeaeuaiiy e?ioeaaiae?anoie?/iiai ia?io ? o?ce/iiai iaaaioaaeaiiy ia na?oeaaee iyc i?ae /an i?ioeaaeo?e aaiiae?ae?co. Aeai? oao?aiiey?ii? ?aia?aie oa aoiea?ae?ia?ao?/iiai aiae?co aeacothoue ia oa, ui oae? ci?ie iaoai?/ii? ooieoe?? na?oey iaooeeueii iiaeooue i?ecaanoe aei oi?ioaaiiy na?oeaai? iaaeinoaoiino? ? ia?eoa?e/ii? a?iien??. Uia i?ia??eoe aieea aaiiae?ae?co ia iane/aiiy e?ia? eeniai, ie aecia/aee ia?oe?aeueiee oene eenith (?I2). O eiio?ieuei?e a?oi? ?I2 aei??aithaaa 71,351,2 ii ?o no. O oai?eo ia OAI aei aaiiae?ae?co ?I2 neeaaeaa 64,392,5 ii ?o no. I?ney aaiiae?ae?co ?I2 noaa 59,533,5 ii ?o no (?<0,05). O oai?eo ia O?II aei aaiiae?ae?co ?I2 neeaa 50,426,3 ii ?o no, a i?ney aaiiae?ae?co noaa 37,754,6 ii ?o no (?<0,05). Ia?oe?aeueiee oene eenith o oai?eo ia OAI ? O?II aei aaiiae?ae?co cieaeaiee o ii??aiyii? c ii?iith. I?ney aaiiae?ae?co o oai?eo iaio a?oi a?aeaoaa?oueny ??cea cieaeaiiy ?I2 , iniaeeai o oai?eo ia O?II. Oaea ??cea cieaeaiiy ?I2, aacoiiaii, i?ecaiaeeoue aei eeniaai? iaaeinoaoiino? oeaiei. I?ney aaiiae?ae?co aeeth/a?oueny “eaneaaeiee” iaoai?ci, yeee i?ecaiaeeoue aei i?ia?anoaaiiy na?oeaai? iaaeinoaoiino? (ca?eueoaiiy e?ioeaaiae?anoie?/iiai ?ici??o oa ia?io, ciaioaiiy e?ioeaainenoie?/iiai ?ici??o oa ca?eueoaiiy e?ioeaainenoie?/iiai ia?io, ca?eueoaiiy a?aeiinii aei aaae iane e?aiai oeoii/ea) o ae?ae?cieo oai?eo oa ca?eueoaiiy ia?eoa?e/ii? a?iien?? (??cea ciaioaiiy ia?oe?aeueiiai oeneo eenith). On? oe? ci?ie iathoue a?eueo ae?aaeaiee oa?aeoa? o oai?eo ia O?II. Ii?o/ ?c ciaioaiiyi ia?oe?aeueiiai oeneo eenith ie aeyaeee ca?eueoaiiy eiioeaio?aoe?? O3. Eiioeaio?aoe?y O3 a ii?i? neeaea 1,8750,3 iiieue/e. Aei aaiiae?ae?co eiioeaio?aoe?y O3 aeinoia??ii aeua ii?ie aeey oai?eo ia OAI iaio a?oi 3,010,2 iiieue/e ? ia O?II 4,280,6 iiieue/e. I?ney aaiiae?ae?co a?aeaoaa?oueny cieaeaiiy eiioeaio?aoe?? O3, aea ??aaiue i?iaeiaaeo? aooe aenieei o OAI 2,510,2 (?<0,05) ? o O?II 2,960,4 (?<0,05). Oae? ci?ie iiaee a i?ecaanoe aei aeniaaeaiiy ooieoe?? ueoiaeaeii? caeice. Uia ioe?ieoe aieea aaiiae?ae?co ia ai?no ooieoe?? oeoiaeaeii? caeice, ie aecia/aee eiioeaio?aoe?th O3 i?ney 10 ? 25 naain?a. I?ney 10 naain?a aeo?aeia eiioeaio?aoe?y O3 i?aeoe/ii ia ci?ieeany. I?ney 25 naain?a io?eiaee aeinoia??ia ciaioaiiy O3 ia 0,99 iiieue/e o oai?eo ia OAI ? ia 1,5 o oai?eo ia O?II. Oae? ci?ie a eiioeaio?aoe?? O3 iiaeia iiynieoe o ca?eueoaii? iio?aae aia?a?? i?ney aaiiae?ae?co. O oai?eo c OII niinoa??aa?oueny a?ia?e?i?aeai?y (eiioeaio?aoe?y caaaeueieo e?i?ae?a o oai?eo ia OAI 9,630,26 ia/ie oa o oai?eo ia O?II 8,250,15 ia/ie) ?, ioaea, iaaaciaea oi?ioaaiiy aoa?ineea?ico aeniea. Aaeeeo ?ieue o oi?ioaaii? aoa?ineea?ico a?ae?a?a? IIE. Ie anoaiiaeee, ui aaiiae?ae?c i?ecaiaeeoue aei a?eueo ae?aaeaieo ci?i IIE. I?ney aaiiae?ae?co ai?no ae??iiaeo eiithaao o oai?eo ia OAI 2,670,3 oi. iae. ? 3,690,1 oi. iae. o oai?eo ia O?II. Iiaeeeai, oea iiaycaii c aenieith eiioeaio?aoe??th O3 ? ia?aeaeueiei cieaeaiiyi ia?oe?aeueiiai oeneo eenith, ye? a oiiaao aaeeeeo aia?aaoe/ieo ao?ao, ye i?e naain? aaiiae?ae?co, iiaeooue i?ecaanoe aei aeoeaaoe?? aiaa?iaieo iaoai?ci?a ieeneaiiy, ye? iinoa/athoue ee?oeie oaeaeeeie ? “aeaoaaeie” aeaeaie aia?a??. Ioaea, iaea?eueo ia?niaeoeaiei aaaaea?oueny a?ae?iaeaiiy noai aioeieneaeaioii? oa?ai?? ia iniia? eiio?ieth ?o aieeao ia aeai? ee?i?eieaai?aoi?iiai ianoaaeaiiy c iaoith: ?iaeea?aeoae?caoe?? i?aeai?o e?eoaaiiy; aeaoieneeaoe?? ? i?aeaeuaiiy /ooeeaino? i?aai?cio oai?iai aei ae?? noa?i?aeieo ai?iii?a ? i?aia?ao?a. Aeey ioe?iee eiina?aaoeaii? oa?ai?? ie aeine?aeeee aieea ?ia?a?oi??a aia?ioaicei-ia?aoai?thth/iai oa?iaioo (?AIO) ? naeaeoeaieo 1-aae?aiiaeieaoi??a ia noai ?AAN ? IOI. A yeino? ?AIO aeei?e- noiaoaaee aaei?o (aiaeai?ee iaeaao), a a yeino? 1-aae?aiiaeieaoi?a aaciea?ae?i (iaoai?ieie), o a?oi oai?eo c o?ii?/iei aeiia?o- eiiao?eoii (OAI), o?ii?/iei i??eiiao?eoii (O?II) ? a?ia?oii?/iith oai?iaith ?? noaae?? (AO). Eiio?ieue a?oa??aeueiiai oeneo i?iaaee /a?ac /a?ac 30, 60 ? 120 oaeeei i?ney i?eeiio e?e?a. I?e iaeiie?aoiiio i?eeii? ie anoaiiaeee, ui aiaeai?ee aeinoia??ii i?aeaeuo? A?I ia 0,52 ia/ie/a (?<0,05) o oai?eo ia OAI, ia 0,69 ia/ie/a (?<0,05) o oai?eo ia O?II, ia 0,67 ia/ie/a (?<0,05) o oai?eo ia AO, ca?eueoo? ai?no aia?ioaiceio ? ia 0,46 ia/ie (?<0,05) o oai?eo ia OAI, ia 0,79 ia/ie (?<0,05) o oai?eo ia O?II, ia 2,47 ia/ie o oai?eo ia AO ? noaa?e?co? c oaiaeaioe??th aei cieaeaiiy ai?no aeueaeinoa?iio. Iaoii?ieie ia? ?ioee aoaeo, iiieaeo? A?I ia 0,55 ia/ie/a (?<0,05) o oai?eo ia OAI, ia 0,23 (?<0,05) o oai?eo ia O?II, ia 0,32 ia/ie/a (?<0,05) o oai?eo ia AO, ? eiioeaio?aoe?th aia?ioaiceio ? ia 0,7 ia/ie/a (?<0,05) o oai?eo ia OAI, ia 0,6 ia/ie/a (?<0,05) o oai?eo ia AO, noaa?e?co? eiioeaio?aoe?th aeueaeinoa?iio. Aei 120 oaeeeie ai?no IOI ci?ieany oaeei /eiii: o oai?eo ia OAI cieaeoaaany ia 7,9 ia/ie (aiaeai?ee) ? i?aeaeuoaaany ia 20 ia/ie (?<0,05)(iaoii?ieie); o oai?eo ia O?II cieaeoaaany ia 7,21 ia/ie (aiaeai?ee) ? i?aeaeuoaaany ia 23,79 ia/ie (iaoii?ieie); o oai?eo ia AO ia ci?ithaaany i?e i?eeii? aiaeai?eeo ? i?aeaeuoaaany ia 24,3 ia/ie (?<9,05) i?e i?eeii? iaoii?ieieo (aeea. ?en 1a,a,a). ?en 1a. Ni?aa?aeiioaiiy ai?iii?a o oai?eo ia i??eiiao?eo i?e canoinoaaii? aiaeai?eeo oa iaoii?ieieo. Aeey oai?eo o aaiiae?ae?c? aeoeaaoe?y ?ai?io iaaaaeaia, oae ye i?ae /an i?ioeaaeo?e aaiiae?ae?co aiia noi?iaiaeaeo?oueny i?aeaeuaiiyi a?oa??aeueiiai oeneo. C ?ioiai aieo, ca?eueoaiiy eiioeaio?aoe?? IOI i?ecaiaeeoue aei cieaeaiiy a?oa??aeueiiai oeneo. Ioaea, c oe??? oi/ee ci?o ia?aaaaeiei aoa i?eeii 1-aae?aiiaeieaoi??a, ye? ?ia?aothoue i?iaeoeoe?th ?ai?io. C ?ioiai aieo, ?ia?a?oi?e AIO cieaeothoue eiioeaio?aoe?th aia?ioaiceio oa aeueaeinoa?iio, ye? iathoue iaaaoeaiee aoaeo ia na?oeaaee iyc ?, a?eueoa oiai, ca?eueoothoue a?ae?iic iao?ii?a, /ei ni?eythoue i?ia?anoaaiith ie?eiai? iaaeinoaoiino?. Ioaea, c oe??? oi/ee ci?o ia?aaaaeiei aoa ae i?eeii ?ia?a?oi??a AIO, ye? iiceoeaii ae?thoue ? ia ea?ae?ii?ioeeoe, ? ia ie?eiao oeaieio. A ieai? ?ic?iaee iioeiaeueii? aioea?ia?oaiceaii? oa?ai?? aeey oai?eo, ye? ia?aaoaathoue ia i?ia?aiiiio aaiiae?ae?c?, ie i?iaaee aeai- oeaeiaao oa?ai?th 18 oai?ei iaoii?ieii, 15 oai?ei aiaeai?eeii ? 17 oai?ei eiia?iiaaio (aiaeai?eeii+iaoii?ieieii). Iiiioa?ai?y aiaeai?eeii aeeth/aea i?eeii 20ia/aeia i?aia?aoo. Ca?eueoaiiy aeic i?aia?aoo ia aaaaeaeiny aeioe?eueiei, oae ye aaeee? aeice aiaeai?eeo iaeaao i?e OII iathoue iao?ioiene/iee aoaeo. Iiiioa?ai?y iaoii?ieieii aeeth/aea i?eeii i?aia?aoo aeicaie a?ae 2040 ia2/aeia. Eiia?iiaaia oa?ai?y aeeth/aea 10 ia aiaeai?eeo + 10 (20)ia iaoii?ieieo ia aeiao. Oa?ai?y i?iaiaeeeany ia i?ioyc? o?ueio oeaei?a. Ia e?iaoeue o?aoueiai oeaeiy a a?oi? i?ie?eiaaieo aiaeai?eeii ie io?eiaee eiio?ieueiaaiee a?oa??aeueiee oene i?ae /an naaino aaiiae?ae?co o 8 (53,3%) oai?eo, a a?oi? i?ie?eiaaieo iaoii?ieieii o 11 (61,1%), a a a?oi? c eiia?iiaaiith oa?ai??th o 15 (88,2%) oai?eo. Oaeei /eiii, aeioe?eueii canoiniaoaaoe eiia?iaoe?th oeeo i?aia?ao?a ye a?eueo aoaeoeaiee iaoiae eiio?ieth a?oa??aeueiiai oeneo a aaiiae?ae?c?. AENIIAEE 1. O oai?eo ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo a noaae?? o?ii?/ii? ie?eiai? iaaeinoaoiino? a i?ioean? aaiiae?ae?co a?aeaoaa?oueny aeoeaaoe?y ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie, ciaioaiiy eii- oeaio?aoe?? iao??eo?aoe/iiai iaioeaeo ? ii?ooaiiy ooieoe?iiaeueieo iieaciee?a na?oeaai-noaeeiii? nenoaie. 2. O oai?eo ia o?ii?/iee i??eiiao?eo o noaae?? o?ii?/ii? ie?eiai? iaaeinoaoiino?, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, oa?aeoa?ii i?aeaeuaiiy eiioeaio?aoe?? aeueaeinoa?iio a aeae?eueea ?ac?a a?eueoa, i?ae o oai?eo ia o?ii?/iee aeiia?oeiiao?eo. 3. O oai?eo ia o?ii?/iee i??eiiao?eo ia i?ia?aiiiio aaiiae?ae?c? ci?ie ia?eoa?e/ii? aaiiaeeiai?ee a?eueo ae?aaeai?, i?ae o oai?eo ia o?ii?/iee aeiia?oeiiao?eo, ui i?iyaey?oueny ??ceei cieaeaiiyi ia?oe?aeueiiai oeneo eenith, ca?eueoaiiyi ia?eoa?e/iiai iii?o ? oi?ioaaiiyi aaiiciiai canoith. 4. Eiioeaio?aoe?? aeueaeinoa?iio, iao??eo?aoe/iiai iaioeaeo oa aeoeai?noue ?ai?io ieacie iathoue iaea?eueoee ei?aeyoe?eiee caycie c aeeiai?eith a?oa??aeueiiai oeneo a i?ioean? aaiiae?ae?co. I?e ni?aa?aeiioaii? eiioeaio?aoe?? aeueaeinoa?iio oa iao??eo?aoe/iiai iaioeaeo iaioa iaeeieoe? a?aeaoaa?oueny i?aeaeuaiiy aeoeaiino? ?ai?io ieacie oa ca?eueoaiiy a?oa??aeueiiai oeneo, a i?e ni?aa?aeiioaii? ai?iii?a aeeae/a aei iaeeieoe? a?oa??aeueiee oene cieaeo?oueny oa aeoeai?noue ieacie noaa?e?co?oueny. 5. I?ae /an aaiiae?ae?co aeeth/a?oueny “eaneaaeiee” iaoai?ci, yeee i?ecaiaeeoue aei i?ia?anoaaiiy na?oeaai? iaaeinoaoiino?, ui oa?aeoa?eco?oueny ca?eueoaiiyi e?ioeaaiae?anoie?/iiai ?ici??o oa ia?io e?aiai oeoii/ea, ca?eueoaiiyi iane e?aiai oeoii/ea a?aeiinii aei aaae. 6. O oai?eo ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo c ie?eiaith iaaeinoaoi?noth, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, ca?eueoaiiy eiioeaio?aoe?? O3 a oiiaao a?ia?e?i?aeai?? ? cieaeaiiy ia?oe?aeueiiai oeneo eenith i?ecaiaeeoue aei iie?auaiiy iieaciee?a ia?aeeniiai ieeneaiiy e?i?ae?a, ui iio?aao? aeeth/aiiy aioeiene- aeaioieo i?aia?ao?a a iniiai? oa?aiaaoe/i? noaie. 7. Eiia?iiaaia oa?ai?y oai?ei ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo o i?aeae?ae?ciiio ia??iae? ?ia?a?oi?aie aia?ioaicei-ia?a- oai?thth/iai oa?iaioo ? 1- aae?aiiaeieaoi?aie aeicaiey? eiio?iethaaoe a?oa??aeueiee oene o 88,2% oai?eo, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, oiae? ye iiiioa?ai?y ?ia?a?oi?aie aia?ioaicei-ia?aoai- ?thth/iai oa?iaioo aeicaiey? c?iaeoe oea o?eueee o 53,3%, a iiiioa?ai?y 1- aae?aiiaeieaoi?aie o 61,1%. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeeiai?ea a?oa??aeueiiai oeneo i?ae /an naaino aaiiae?ae?co ? a i?aeae?ae?ciiio ia??iae? caycaia c eieeaaiiyi ai?noo ?ii?a oa i?yii ei?aeth? c? ci?iaie eiioeaio?aoe?? aeueaeinoa?iio, iao??eo?aoe/iiai iaioeaeo oa aeoeaiino? ?ai?io ieacie a e?ia?. Ioaea, aeey a?eueo ei?aeoiiai eiio?ieth a?oa??aeueiiai oeneo ? iiia?aaeaeaiiy eiai i?aeaeuaiiy i?ae /an aaiiae?ae?co, ii?o/ ?c aecia/aiiyi ?ii?a e?ia?, aaaeaii aecia/eoe o oai?eo, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, ai?no oeeo ai?iii?a oa ia/eneeoe ?o ni?aa?aeiioaiiy aei aaiiae?ae?co. 2.Eiia?iiaaia oa?ai?y ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo c 1- aae?aiiaeieaoi?aie aeicaiey? a cia/i?e i??? eiio?i- ethaaoe aeeiai?eo a?oa??aeueiiai oeneo o oai?eo ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, ia a?aei?io a?ae iiiioa?ai?? oeeie i?aia?aoaie. Oea aeicaiey? a?aeaeaoe ia?aaaao oaeiio canoinoaaiith i?aia?ao?a aeey oai?eo a aaiiae?ae?c? ye iaea?eueo aaeaeaaoiiio ? i?aaeeueiiio. 3. I?aeaeuaiiy ia?aeeniiai ieeneaiiy e?i?ae?a o oai?eo ia o?ii?/iee aeiia?oeiiao?eo ? i??eiiao?eo, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, aeiaaa? canoinoaaiiy noai aioeieneaeaioii? oa?ai?? c iaoith aeaoieneeaoe?? ? i?aeaeuaiiy /ooeeaino? i?aai?cio oai?iai aei ae?? noa?i?aeieo oa ?ioeo i?aia?ao?a, iiaeiaaeaiiy no?ie?a ?ai?n??. NIENIE Ae?OEIAAIEO I?AOeUe 1. Caai?oeueei A.E., E?ooeeia N.I., Aiae?ae/aiei A.A., E?ooeeia A.N., Aaneean E.I. Eiioiieiiieaeniua ii?aaeaiey ieiea?aea o aieueiuo aeiia?oeiiao?eoii e aiciiaeiinoe eo ei??aeoeee // A?niee i?iae. a?ie. oa iaae.-1997.-Aei.16.-N.44-46. 2. Aaneean E.I. Eco/aiea ?aieiaiaeioaiceiaeueaeinoa?iiiaie nenoaiu e iao?eeo?aoe/aneiai oaeoi?a o aieueiuo, iaoiaeyueony ia aaiiaeeaeeca // I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeeiaeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey:O?. EAIO.-O.134, *.2.-Neioa?iiieue, 1998.-N.94-100. 3. E?ooeeia N.I., Aaneean E.I., Aaneean N.I., Ona/aiei E.A., Eo?a/ E.E. Iaeioi?ua iniaaiiinoe aeeiaieee a?oa?eaeueiiai aeaaeaiey o aieueiuo, iaoiaeyueony ia i?ia?aiiiii aaiiaeeaeeca // I?iaeaiu, aeinoeaeaiey e ia?niaeoeau ?acaeoey iaaeeeiaeieiae/aneeo iaoe e i?aeoe/aneiai cae?aaiio?aiaiey:O?. EAIO.-O.134, *.2.-Neioa?iiieue, 1998.-N.121-126. 4. Aaneean E.I., Aaneean N.I. N?aaieoaeueiay ioeaiea aeeyiey yaeieoa e aaciea?aeeia ia ?aieiaiaeioaiceiaeueaeinoa?iiiaoth nenoaio //Oaa?e/aneee iaaeeei-aeie. aanoi.-1998.-?3-4.-N. AIIOAOe?ss Aan?ean Eiinoaio?iin. Ooieoe?iiaeuei? ci?ie na?oeaainoaeeiii? nenoaie o oai?eo ia o?ii?/iee aeiia?oeiiao?eo oa i??eiiao?eo, ye? ia?aaoaaee ia i?ia?aiiiio aaiiae?ae?c?, oa oeyoe ?o ei?aeoe??.-?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.02 aioo??oi? oai?iae. E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. N.?. Aai?a??anueeiai IIC Oe?a?ie, N?ioa?iiieue, 1999. Ie io?eiaee iia? aeai? uiaei aieeao aaiiae?ae?co ia noai na?oeaainoaeeiii? nenoaie. Aaiiae?ae?c aeoea?co? ?ai?i-aia?ioaicei-aeueaei-noa?iiiao nenoaio, ciaioo? eiioeaio?aoe?th iao??eo?aoe/iiai iaioeaeo, i?aeaeuo? noaeeiiee ii?? oa ia?i oee?eoethth/i? e?ia?, ui aaaea aei oi?ioaaiiy na?oeaai? iaaeinoaoiino?. Aeeiai?ea ci?i a?oa??aeueiiai oeneo caeaaeeoue a?ae eiioeaio?aoe?? aeueaeinoa?iio oa iao??eo?aoe/iiai iaioeaeo, ?o ni?aa?aeiioaiiy. O oai?eo ia i?ia?aiiiio aaiiae?ae?c? i?aeaeuaiiy ??aith O3 a oiiaao a?ia?e?i?aeai?? oa ciaioaiiy ia?oe?aeueiiai oeneo eenith i?ecaiaeeoue aei iineeaiiy ia?aeeniiai ieeneaiiy e?i?ae?a. Oaeei /eiii, iaiao?aeii ai?iaaaeaeoaaoe o caaaeueiii?eeiyo? noaie oa?ai?? noaie aioeieneaeaioii? oa?ai??. A?eueo ?aoe?iiaeueia eiia?iiaaia oa?ai?y ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo oa 1- aae?aii- aeieaoi?aie aeicaiey? eiio?iethaaoe a?oa??aeueiee oene o 88,2% oai?eo ia i?ia?aiiiio aaiiae?ae?c?. Eeth/ia? neiaa: ooieoe?y na?oeaainoaeeiii? nenoaie, o?ii?/iee aeiia?oeiiao?eo, o?ii?/iee i??eiiao?eo, o?ii?/ia ie?eiaa iaaeinoaoi?noue, aaiiae?ae?c. AIIIOAOeEss Aaneean Eiinoaioeiin. Ooieoeeiiaeueiua eciaiaiey na?aea/ii-ninoaeenoie nenoaiu o aieueiuo n aeiia?oeiiao?eoii e ieaeiiao?eoii, iaoiaeyueony ia i?ia?aiiiii aaiiaeeaeeca, e iooe eo ei??aeoeee. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaiie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.02 – aioo?aiiea aieacie –. E?uineee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. N.E. Aai?aeaaneiai, 1999. Enneaaeiaaieey iniiaaiu ia aiaeeca ooioeeiiaeueiiai ninoiyiey na?aea/ii-ninoaeenoie nenoaiu o 20 aieueiuo aeia?oiie/aneie aieaciueth II noaaeee, 20 aieueiuo aeia?oiie/aneie oi?iie o?iie/aneiai aeiia?oeiiao?eoa aac o?iie/aneie ii/a/iie iaaeinoaoi/iinoe, 20 aieueiuo aeia?oiie/aneie oi?iie o?iie/aneiai ieaeiiao?eoa aac o?iie/aneie ii/a/iie iaaeinoaoi/iinoe, 33 aieueiuo o?iie/aneei aeiia?oeiiao?eoii n o?iie/aneie ii/a/iie iaaeinoaoi/iinoueth IIA – IIIA noaaeee e 22 aieueiuo o?iie/aneei ieaeiiao?eoii n o?iie/aneie ii/a/iie iaaeinoaoi/iinoueth IIA – IIIA noaaeee. Aeey ii?aaeaeaiey oi?iu aeiia?oeiiao?eoa e ieaeiiao?eoa e noaaeee o?iie/aneie ii/a/iie iaaeinoaoi/iinoe eniieueciaaeinue eeanneoeeaoeey N.E. ?yaiaa. Ana aieueiua n o?iie/aneie ii/a/iie iaaeinoaoi/iinoueth iaoiaeeeenue ia i?ia?aiiiii aaiiaeeaeeca. A oiaea enneaaeiaaiey iieacaii, /oi aieueiuo o?iie/aneei aeiia?oeiiao?eoii e ieaeiiao?eoii n o?iie/aneie ii/a/iie iaaeinoaoi/iinoueth a i?ioeanna aaiiaeeaeeca i?ienoiaeeo aeoeaaoeey ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu, oiaiueoaiea eiioeaio?aoeee iao?eeo?aoe/aneiai iaioeaea e ia?ooaiea ooieoeeiiaeueiuo iieacaoaeae na?aea/ii-ninoaeenoie nenoaiu. Aieaa oiai aeey aieueiuo o?iie/aneei ieaeiiao?eoii n o?iie/aneie ii/a/iie iaaeinoaoi/iinoueth iaoiaeyueony ia i?ia?aiiiii aaiiaeeaeeca, oa?aeoa?ii iiauoaiea eiioeaio?aoeee aeueaeinoa?iia a ianeieueei ?ac aieueoa, /ai aeey aieueiuo o?iie/aneei aeiia?oeiiao?eoii. O aieueiuo o?iie/aneei ieaeiiao?eoii ia i?ia?aiiiii aaiiaeeaeeca eciaiaiey ia?eoa?e/aneie aaiiaeeiaieee aieaa au?aaeaiu, /ai o aieueiuo o?iie/aneei aeiia?oeiiao?eoii, /oi i?iyaeyaony ?aceei nieaeaieai ia?oeeaeueiiai aeaaeaiey eenei?iaea, oaaee/aieai ia?eoa?e/aneiai nii?ioeaeaiey e oi?ie?iaaieai aaiiciiai canoiy. Eiioeaio?aoeee aeueaeinoa?iia, iao?eeo?aoe/aneiai iaioeaea e aeoeaiinoue ?aieia ieaciu eiatho iaeaieueooth ei??aeyoeeiiioth naycue n aeeiaieeie a?oa?eaeueiiai aeaaeaiey a i?ioeanna aaiiaeeaeeca. I?e niioiioaiee eiioeaio?aoeee aeueaeinoa?iia e iao?eeo?aoe/aneiai iaioeaea iaiueoa aaeeieoeu i?ienoiaeeo iiauoaiea aeoeaiinoe ?aieia ieaciu e oaaee/aiea a?oa?eaeueiiai aeaaeaiey, a i?e niioiioaiee ai?iiiia aeeaea e aaeeieoea a?oa?eaeueiia aeaaeaiea nieaeaaony e aeoeaiinoue ?aieia ieaciu noaaeeece?oaony. Onoaiiaeaii, /oi ai a?aiy aaiiaeeaeeca aeeth/aaony ''eaneaaeiue'' iaoaieci, eioi?ue i?eaiaeeo e i?ia?anne?iaaieth na?aea/iie iaaeinoaoi/iinoe, oa?aeoa?ecothuaeny oaaee/aieai eiia/ii-aeeanoiee/aneiai ?acia?a e iau?ia eaaiai aeaeoaei/ea, oiaiueoaieai eiia/ii-nenoiee/aneiai ?acia?a e oaaee/aieai eiia/ii-nenoiee/aneiai iau?ia eaaiai aeaeoaei/ea, oaaee/aieai iannu eaaiai aeaeoaei/ea ioiineoaeueii aana. O aieueiuo, iaoiaeyueony ia i?ia?aiiiii aaiiaeeaeeca, iaaethaeaaony oaaee/aiea eiioeaio?aoeee O3 a oneiaeyo aeia?eeieaeaiee, a nieaeaiea ia?oeeaeueiiai aeaaeaiey eenei?iaea i?eaiaeeo e oeo/oaieth iieacaoaeae ia?eeeniiai ieeneaiey eeieaeia, /oi o?aaoao aeeth/aiey aioeieneaeaioiuo i?aia?aoia a iniiaiua oa?aiaaoe/aneea noaiu. Aieaa ?aoeeiiaeueiay eiiaeie?iaaiiay oa?aiey aieueiui o?iie/aneei aeiia?oeiiao?eoii e ieaeiiao?eoii a iaaeaeeaeeciii ia?eiaea eiaeaeoi?aie aiaeioaicei-i?aa?auathuaai oa?iaioa e 1-aae?aiiaeieaoi?aie iicaieyao eiio?iee?iaaoue a?oa?eaeueiia aeaaeaiea o 88,2% aieueiuo, iaoiaeyueony ia i?ia?aiiiii aaiiaeeaeeca, oiaaea eae iiiioa?aiey eiaeaeoi?aie aiaeioaicei-i?aa?auathuaai oa?iaioa iicaieyao naeaeaoue yoi oieueei o 53,3%, a iiiioa?aiey 1-aae?aiiaeieaoi?aie - o 61,1%. Eeth/aaua neiaa: ooieoeee na?aea/ii-ninoaeenoie nenoaiu, o?iie/aneee aeiia?oeiiao?eo, o?iie/aneee ieaeiiaoeo, o?iie/aneay ii/a/iay iaaeinoaoi/iinoue, aaiiaeeaeec. SUMMARY Vasilas Konstantinos. Functional changes is cardiovascular system at the patients with glomerulonephritis and pielonephritis, taking place on program dialysis, and way of their correction. - Manuscript. Thesis for a candidate’s in medical sciences by speciality 14.01.02 - therapy -. The Crimean state medical university by S.I. Georgievski, 1999. It was received new data about influence which renders dialysis in a condition of cardiovascular systems. Dialysis activates renine-angiotensin-aldosteron system decreases concentration of atrial natriuretic peptide, increases vascular periferical resistance, increases venous blood stagnation and volume of circulating blood, that leads to formation of heart failure decrease. Dynamics of changes in blood pressure depends on concentration of aldosteron and atrial natriuretic peptide and their ratio. At the patients taking place on program dialysis the increase of concentration O3 in conditions hyperlipidaemia and reduction of partial pressure of oxygen results in improvement of parameters of lipid oxidation, that requires inclusion of antioxidants in basically schemes of the therapy. The more rational combined therapy of beta 1 adrenoblocators and inhibitors of angiotensin converting enzyme, allows to supervise a?oa?eaeueiia pressure at 88,2 % of the patients who are taking place on program aaiiaeeaeeca Key words: function of cardiovascular system, chronic glomerulonephritis chronic pielonephritis, chronic renal failure, dialysis.

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