OE?A?INUeEA AEAAeAI?ss AA?A?IEO IAOE

?INOEOOO NAEIA?NOAA OAAI

AAEEI IEUeAA IEAEN??AIA

OAeE 612.1:547.964.42

O?C?IEIA?*IA AEOEAI?NOUe I?E?IAeIIAI

IAIOEAeIIAI EIIIEAENO IE?IE OA EIAI

NEIOAOE*IEO AIAEIA?A A OIIAAO

II?IE ? I?E AENIA?EIAIOAEUeIEO ?? II?OOAIIssO

03.00.13 — o?c?ieia?y ethaeeie ? oaa?ei

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Iieoaaa – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Oeaio?aeuei?e iaoeiai-aeine?aei?e eaai?aoi???
Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai?? (i. Iieoaaa)

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, noa?oee iaoeiaee

ni?a?ia?oiee EAEAeAOAA ?AI?
IAO?IAE*,

caa?aeoaa/ Oeaio?aeueii?
iaoeiai-aeine?aeii?

eaai?aoi???, Oe?a?inueea iaaee/ia
noiiaoieia?/ia

aeaaeai?y

Io?oe?ei? iiiiaioe: — aeieoi? a?ieia?/ieo iaoe, i?ia?aeiee iaoeiaee

ni?a?ia?oiee ?N OAAI IA?OEIAIEI
I?IA

AIOII?AIA, ?inoeooo naeia?noaa
OAAI;

— eaiaeeaeao a?ieia?/ieo iaoe EACA??AA CI?EIA IEAENAIAe??AIA,
caa?aeoaa/ eo?nii iaoieia?/ii? o?c?ieia?? Iieoaaneiai o?e?aeo einoeoooo
ia?iaeii? iaaeeoeie (i.Iieoaaa)

I?ia?aeia onoaiiaa: — Ee?anueeee iaoe?iiaeueiee oi?aa?neoao

?i. Oa?ana Oaa/aiea

Caoeno a?aeaoaeaoueny “_10 ”_aa?aniy 1999?.

a 10 aiaeei ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 44.351.01 i?e
?inoeooo? naeia?noaa OAAI ca aae?anith: 314006, Iieoaaa, Oaaaenueea
Iiaeea.

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo

naeia?noaa OAAI (i.Iieoaaa, Oaaaenueea Iiaeea).

Aaoi?aoa?ao ?ic?neaiee “26” 07 1999 ?.

A/aiee nae?aoa? eaiaeeaeao

a?ieia?/ieo iaoe
I?aeoa?aaa I.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aei nueiaiaeaiiy iaei??th c iaeaaaeeea?oeo
i?iaeai caeeoa?oueny aca?iiae?y no?oeoo?ieo aeaiaio?a oeaiei o
aaaaoiee?oeiiiio i?aai?ci? [Oaia?iai Aeae., Oaia?iai O. 1989].
*eneaiieie aeine?aeaeaiiyie aenoiooi ? aeiaaaeaii i?eiouaiiy i?i
iayai?noue a i?aai?ci? a?ieia?/ieo ?aaoeyoi??a iaioeaeii? i?e?iaee
[Eociee A.E., Ii?icia A.A., Oaaeinii A.O., 1998; *eiain A.E., 1984;
O?ieueeen A.A., 1999], ye? cae?eniththoue ia?aiin ?ioi?iaoe??,
iaiao?aeii? aeey ooieoe?iioaaiiy, ?icaeoeo, aca?iiae?? ee?oeiieo
iiioeyoe?e. Niieoee iie?iaioeaeii? i?e?iaee caaacia/othoue ee?oeii?
aca?iica’ycee a iaaeao oiai i?aaio, a yeiio aiie ooai?ththoueny.
I?iaeaia aea/aiiy iaoai?cio ae?? ? canoinoaaiiy i?e?iaeieo iaioeaeieo
a?i?aaoeyoi??a ? iaei??th c eeth/iaeo a no/ani?e a?ieia??. Aieiaiith
ooieoe??th ?aaoeyoi?ieo iaioeae?a ? o/anoue o eiio?ie? aaiaoe/iiai
aiiainoaco, ?aia?aoeaieo oa aaeaioaoe?eieo i?ioean?a, ianiaoeeo?/ii?
?acenoaioiino? i?aai?cio [Eociee A.E.1988; Eociee A.E., Ii?icia A.A.,
Oaaeinii A.O. 1998; Oaaeinaaa A.A. oa ni?aaaoi?e 1987; Low T.L. et al.
1984].

Oae? iaioeaei? eiiieaene caeaoi? aieeaaoe ia eeoa ia caei?ia? ee?oeie,
aea ? ia noai iaoaaie?/ieo i?ioean?a a ooeiaeaeaieo ee?oeiao, ci?ithth/e
?o, oaeei /eiii ii?iae?coth/e ooieoe??. Anoaiiaeaii, ui ?aaoeyoi?i?
iaioeaee aieeaathoue ia aeoeai?noue E+, Na+, Na2+- AOO-ac, ci?iththoue
oinoie?i?aeiee neeaae iaia?ai ee?oei. Ia aeeeth/aii, ui iiae?ai?
aeanoeaino? i?eoaiaii? aaaaoueii iaioeaeiei eiiieaenai, ? caeaaeaoue
a?ae oiai, c yei? oeaieie aiie aeae?eai?, a?ae ooieoe?iiaeueiiai noaio
oeaiei, a oaeiae aeaeo iaoieia?/iiai i?ioeano [Eociee A.E. Ii?icia A.A.,
Oaaeinii A.O., 1998].

I?aia?aoe o?c?ieia?/ii aeoeaieo iaioeae?a io?eiai? c ??cieo i?aai?a ?
oeaiei [Aeoeianeee TH.A., 1990; Eaeaeaoaa E.I. oa ni?aaaoi?e 1992;
Eeoaeiaiei I.A. 1992; Neeaiei TH.E. 1992] Aiie aeyaeythoue ae?aaeaio
iiaeoethth/o oa ei?aaoth/o i?aaiiniaoeeo?/io ae?th ia noai nenoai
?aaoeyoe?? a o?aaeaiiio i?aai? oa a oe?eiio i?aai?ci?. Oaeei /eiii,
iie?iaioeaei? aeno?aeoe iathoue ianooiio aoaeoi?io ni?yiiaai?noue
[Eaeaeaoaa E.I. 1994]: ae?y ia oie i?aai, ?c yeiai aiie aeae?eai?; ia
i?aaie, yee c iei o?c?ieia?/ii ei?aeththoue; ianiaoeeo?/ia ae?y ia
i?aai?ci o oe?eiio.

Aaaeeea?noue aea/aiiy ?aaoeyoe?? o?c?ieia?/ieo ? iaoieia?/ieo i?ioean?a
o ie?oe? ia aeeeeea? noii?ao, ine?eueee ie?ea ? ia’?eoii ?aaoeyoi?ii?
ae?? aaaaoueio a?ieia?/ii aeoeaieo ?a/iaei. Oeae i?aai aeoaea /oeii
?aaao? ci?iith ooieoe?iiaeueii? aeoeaiino? ia iaioeaei? a?ieia?/ii
aeoeai? ?a/iaeie. Iai?eeeaae, aioeae?o?aoe/iee ai?iii aa?a o/anoue o
o?c?ieia?/ieo i?ioeanao, ye? a?aeaoaathoueny a iiceia?e ?a/iaei? ie?ie,
iniaeeai a ?aaani?aoe?? aiaee. E?i?ie, ui ooai?ththoueny a ie?eao,
iathoue ?noioiee aieea ia ?acenoaioi?noue ?o noaeei, ca?eueoothoue
aene?aoe?th iao??th ? aiaee [Gill J.R. et all.1965]. A?a?i?i aacii?anei
(AAI) ia? ae?acio o?c?ieia?/io ae?th ia ie?eiao ? iaie?eia? oeaieie,
cae?enith? i?ani?io ae?th ia aeaaeaiueeo ioneoeaoo?o noaeei
[?eaaeue/aiei A.E. 1998]. AAI /eieoue caeaaeia a?ae aeice aaeueioaaiiy
aea?eueiaiiy ie?eaie ?ai?io [Shade R.E et al. 1973; Khokhar A.M. et al.
1976; Hesse B. et al. 1977], noeioeth? neioac i?inoaaeaiaeei?a iiceiaith
?a/iaeiith ie?ie [Zusman R.M. et al 1974].

C ie?ie aoa aeae?eaiee iaioeaeiee eiiieaen, yeee aeyaea ae?aaeaio
?aaoeyoi?io ae?th ia i?ioeane cn?aeaiiy e?ia?, o?a?eiie?c, aeoeai?noue
?ioiii? nenoaie, aieea ia i?ioeane ?aaaia?aoe??, a oaeiae ia i?ioeane
nae?aoe?? ? ?aaani?aoe?? a ie?eao [Eaeaeaoaa E.I. oa ni?aaaoi?e 1994,
Aeue-Ooe?e N.O., Ai?aa/aa A.A., Oth?ei A.A., Aiaeee ?.A., 1996]. Oaeei
/eiii, aenia?eiaioaeueia aea/aiiy a?ieia?/ii? aeoeaiino? iaioeaeieo
eiiieaen?a ? iaei??th c aaaeeeaeo i?iaeai ye o?c?ieia??, oae ?
iaoio?c?ieia??, oiio ui ? an? i?aenoaae aaaaeaoe, ui iaeaeeae/ei /anii
aiie ciaeaeooue iaeoe?oa canoinoaaiiy a ee?i?/i?e i?aeoeoe?. O oie aea
/an, ia?niaeoeae i?aeoe/iiai aeei?enoaiiy i?e?iaeieo iaioeae?a
aeiaaathoue ?ic?iaee neioaoe/ieo ?o aiaeia?a. Inoaii?i /anii aoee
io?eiai? neioaoe/i? aiaeiae iaioeaeiiai eiiieaeno ie?ie [Eaeaeaoaa E.I.
1995], ye? iathoue oaeo ai?iieeneioio iine?aeiai?noue:
i?i-aeo-e?c-ani-na?-a?a-e?c – (PEKDSRK), i?i-aeo-eec-ani-eae-a?a-e?c-
(PEKDLRK), i?i-aeo-e?c-ani-ani-a?a-eae- (PEKDDRL) (a aeoaeeao iaaaaeaiee
iaeiie?oa?iee eiae ai?iieeneio). Ca neioac iaioeae?a-aiaeia?a i?eiinei
iiaeyeo i?io. ?aiaic? ? aeieoi?o Noaoaiia?/o (i. Aaeaeaeueaa?a,
i?iaoeuee?e oeaio? aeine?aeaeaiue ?aeo). Io?eiai? neioaoe/i? noano?aoe
aeei?enoiaoaaeenue a iiaeaeueo?o iaoeo aeine?aeaeaiiyo c iaoith
oi?ioaaiiy oai?aoe/ii? iniiae aeey ?o iiaeaeueoiai canoinoaaiiy.
Aeoeai?noue neioaoe/ieo iaioeae?a ii??aithaaeanue c aeoeai?noth
i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeaia ?iaioa ?
o?aaiaioii iaoeiai-aeine?aeieo ?ia?o: IIC Oe?a?ie — «?ieue aeenaaeaino
iaioeaea?a?/ii? nenoaie ?aaoeyoe?? a ?icaeoeo oeiiaeo iaoieia?/ieo
i?ioean?a ? oeyoe ?? a?aeiiaeaiiy ?ioi?iaoe?eieie iieaeoeaie
iie?iaioeaeii? i?e?iaee»; (UA01001570?); AeEIO Oe?a?ie — «?ieue
aeenaaeaino nenoaie iie?iaioeaeii? ?aaoeyoe?? a ?icaeoeo iaoieia?/ieo
noai?a, iia’ycaieo ?c ae??th iani?eyoeeaeo oaeoi??a ciai?oiueiai
na?aaeiaeua, ? oeyoe ei?aeoe?? i?aia?aoaie iie?iaioeaeii? i?e?iaee» (N
01934007913).

Iaoa oa caaaeaiiy aeine?aeaeaiiy. Iaoith aeine?aeaeaiiy aoei aea/aiiy
o?c?ieia?/ii? aeoeaiino? i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa eiai
neioaoe/ieo aiaeia?a ca o?c?ieia?/ieo oiia oa i?e aeayeeo
aenia?eiaioaeueieo iiaeaeyo iaoieia?/iiai noaio aeey iiaeeaeaiiy ciaiue
i?i i?e?iaeo iaioeaeii? ?aaoeyoe?? ooieoe?e ie?ie.

A?aeiia?aeii aei iaoe ?iaioe aoee iinoaaeai? caaea/? aeine?aeeoe:

— ae?th i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa eiai neioaoe/ieo
aiaeia?a ca o?c?ieia?/ieo oiia;

— o?c?ieia?/io aeoeai?noue i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa
eiai neioaoe/ieo aiaeia?a i?e aenia?eiaioaeueiiio aooi?ioiiiio iao?eo?
ia uo?ao ? oii’yeao c ioe?ieith aeaeiniaoeeo?/iino? ae??;

— o?c?ieia?/io aeoeai?noue i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa
eiai neioaoe/ieo aiaeia?a i?e oiene/iiio o?aaeaii? iao?io?iiieie
?a/iaeiaie;

— ii??aiyoe o?c?ieia?/io aeoeai?noue iaioeaeiiai eiiieaeno ie?ie oa eiai
neioaoe/ieo aiaeia?a ye iioaioe?eieo e?ea?nueeeo i?aia?ao?a.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Aia?oa iieacaii, ui i?e?iaeiee
iaioeaeiee eiiieaen ie?ie aa?a o/anoue o ?aaoeyoe?? aaeeii?
o?c?ieia?/ii? nenoaie i?aeo?eiee ?acenoaioiino? i?aai?cio, yea a naith
/a?ao, ooai?aia nenoaiaie aioeieneaeaioiiai caoenoo, aaiinoaco oa
?ioi?oaoo. Oe? aeai? i?aeoaa?aeaeai? i?e aeei?enoaii? neioaoe/i?o
iaioeae?a. Iieacaii, ui neioaoe/i? iaioeaee PEKDSRK, PEKDLRK, PEKDDRL
iathoue o?c?ieia?/io aeoeai?noue, ni?yiiaaio ia ?aaoeyoe?th i?ioean?a
IIE, AI aaiinoaco oa ?ioi?oaoo, yea ca?aa?oueny c aeoeai?noth
i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie.

Aia?oa aeiaaaeaii, ui neioaoe/i? iaioeaee PEKDSRK, PEKDLRK, PEKDDRL
iiaeooue aooe aeei?enoai? aeey aeine?aeaeaiiy iaioeaeii? ?aaoeyoe??
iaoaaie?/ieo i?ioean?a (IIE oa o?c?ieia?/ii? AIN) a ie?eao. Iieacaii, ui
aeine?aeaeai? neioaoe/i? iaioeaee ia iathoue iciae aeaeiniaoeeo?/iino?
ae??, ui ia?aaeaa/a? oi?aa?naeuei?noue iaioeaeii? ?aaoeyoe?? ie?ie o
??cieo aeae?a. Io?eiai? iia? aeai?, ui i?aeoaa?aeothoue eiioeaioe?th i?i
?nioaaiiy a ie?eao eieaeueii? nenoaie iaioeaeii? ?aaoeyoe??, yea aieeaa?
ia o?eueee ia o?c?ieia?/i? i?ioeane a oeueiio i?aai?, aea e a ?ioeo
i?aaiao oa nenoaiao (e?ia, oeion, e?noeiaee iicie).

?ice?eoa o?c?ieia?/ia aeoeai?noue neioaoe/ieo iaioeae?a aeicaiey?
?icaeyaeaoe ?o ye iiaeeeaeo ei?aeoi??a o?c?ieia?/ieo i?ioean?a,
ii?ooaieo i?e ie?eia?e iaoieia??.

I?aeoe/ia oe?ii?noue io?eiaieo ?acoeueoao?a. Iaea?aeai? ?acoeueoaoe, ye?
noinothoueny o?c?ieia?/ii? ae?? neioaoe/ieo iaioeae?a PRKDSRK ? PEKDDRL,
iiaeooue aooe aeei?enoai? aeey iiaeaeueoiai ?o aeine?aeaeaiiy a ee?i?oe?
c iaoith canoinoaaiiy a yeino? a?iei?aeoi??a nenoai: ?ioiii?.
aioeieneaeaioii?, aaiinoaco. Ie?ai? iaoa??aee aeena?oaoe?? ? o?aaiaioii
aeiee?i?/ieo ?nieo?a iaioeaeiiai eiiieaeno ie?ie, ye iioaioe?eiiai
e?ea?nueeiai i?aia?aoo c oa?aiaaoe/ieie aeanoeainoyie.

Iniaenoee aianie caeiaoaa/a. Aaoi? iniaenoi ?ic?iaea i?ia?aio iaoeiaeo
aeine?aeaeaiue, aeeiiaa oeeoieia?/i? oa ?ioiieia?/i? aeine?aeaeaiiy.
Naiino?eii i?ia?a aiae?c anueiai io?eiaiiai oaeoe/iiai iaoa??aeo.
?ic?iaea iniiaieo iieiaeaiue ? aeniiae?a ?iaioe oaeiae iaeaaeeoue
aeena?oaioo.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
iia?aeiieai? ia i?aenoieiaeo iaoeiaeo eiioa?aioe?yo Oe?a?inueei?
iaaee/ii? noiiaoieia?/ii? aeaaeai?? (1994-1996); eiioa?aioe?yo iieiaeeo
a/aieo «O?c?ieia?y ? iaoieia?y ia?aeeniiai ieeneaiiy, aaiinoaco ?
?ioiiaaiaco» (1995, 1996, 1997, 1998, 1999 Iieoaaa).

Ai?iaaoe?y aeena?oaoe?? i?iaaaeaia ia can?aeaii? Ai?iaaoe?eii? ?aaee
?1 Oe?a?inueei? iaaee/ii? noiiaoieia?/ii? aeaaeai?? (1999).

Ioae?eaoe??. ?acoeueoaoe aeena?oaoe?? aeeeaaeaii a 6 iaoeiaeo ?iaioao.

Ianya ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 119 noi??ieao ae?oeiaaiiai
oaenoo oe?a?inueeith iiaith ? neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, ?icae?eo “Iaoa??aee oa iaoiaee aeine?aeaeaiue”, aeanieo
aeine?aeaeaiue, iaaiai?aiiy io?eiaieo ?acoeueoao?a, aeniiae?a, nieneo
aeei?enoaieo e?oa?aoo?ieo aeaea?ae, ui i?noeoue 174 ?iaioe, c ieo 102 —
eaoei?oeath. Aeena?oaoe?y i?noeoue 20 oaaeeoeue, ?ethno?iaaia 8
i?e?ioioia?ao?yie.

IAOA??AEE OA IAOIAeE AeINE?AeAEAIIss

Aeey ae??oaiiy iinoaaeaieo caaaeaiue aeei?enoaee 96 a?eeo
noaoaaic??eeo uo??a-naioe?a e?i?? Wistar oa 72 cieioenoeo oii’yea.

*anoeia niinoa?aaeaiue aoea i?iaaaeaia ia e?ia? 25 aeiii??a a?eii 25 –
31 ??e. O a?aeiia?aeiino? c caaaeaiiyie ? ia?aieie aenia?eiaioaeueieie
iiaeaeyie aoee aeei?enoai? oeeoieia?/i?, ?ioiieia?/i?, a?io?i?/i? ?
a?noieia?/i? iaoiaee aeine?aeaeaiiy, ye? iiaeai? a oaae. 1

Oaaeeoey 1.

IAOIAeE AeINE?AeAEAIUe

Iieacieee,

ui aea/aeeny Noano?ao Aaoi?e iaoiaeee

O- ? A-e?ioioeeoe O-oaeia?e,

O-noi?ani?e, I-ee?oeie. e?ia, ethaee Eaaaaeaa E.A.,

Iaiyeeia E.Ae., 1990

2. O- ? A-e?ioioeeoe e?ia, oaa?eie Binaghi R.A., 1975

3.Iaia?aii? ia?ea?e e?ioioeeo?a – CD-3, 4,8,72. e?ia Boyum A., 1968

4. EEA e?ia Ieaa?aaneee A.A., 1978

5. E?euee?noue a?eo?ioeeo?a e?ia Iaiueoeeia A.A., 1987

6. Oaaioeeoic e?ia Herscowitz H.B., 1981

7. E?euee?noue eaeeioeeo?a e?ia Iaiueoeeia A.A., 1987

8.Aeanoo?ainoi?iaoe?y e?ia *a?iooaiei A.O., 1978

9.Caeeoeiaee acio e?ia I?aaeoa/aineee A.A., 1950

10. NIAe e?ia A?onia I.N., e ae?. 1976

11. Eaoaeaca e?ia A?oeiiaa I.A., 1988

12. Ae??iia? eii’thaaoe ieacia Aine?anaineee I.I., 1982

13.Oea?oeiieaci?i ieacia Eiea A.A., e ae?. 1982

14. Oei?eaee ieacia Iaiueoeeia A.A., 1987

15.A-e?iii?ioa?aee ne?iaaoea Iaiueoeeia A.A., 1987

16.Oeeoio?iiieneaeaca oeaieia ie?ie Straus W., 1954

17.E?aaoei?i ne?iaaoea Popper H., 1937

18.Na/iaeia ne?iaaoea Breintk, 1970

19.E?iaoeea iaeiie/aiiy IAeA oeaieie ie?ee Aeaaeeie?ia TH.A., 1972 ,

A?/aeia A.E., 1972

20.Oieanoa?ei ne?iaaoea Iaiueoeeia A.A., 1987

21. E?euee?noue ?IE oa AeIE a oeaieiao oeaieie ie?ie O?oaeiethaiaa I.O.,
1977

22. *an ?aeaeueoeeo?eaoe?? ieacia Bergerhof H.D., Roka L. 1954

23.I?io?iia?iiaee /an ieacia Quick A.J., 1966

24.O?iia?iiaee /an ieacia Biggs R.M., et. al.

25.A*O* ieacia Biggs R.M.

26.Aioeo?iia?i – ??? ieacia Hensen A. et al.

27.O?a?eiie?c ieacia Eioiaueeiaa I.A.,

Oaaei?iaa C.Ae. 1966

28.Niiioaiiee aaiie?c a?eo?ioeeo?a e?ia Nie?e/aa A.A. oa ae?. 1979

Aenia?eiaioaeuei? a?oie oaa?ei

Oaaeeoey 2

? na??? Aenia?eiaioaeueia iiaeaeue Aeica, oa?i?i ? niin?a aaaaeaiiy
o?c?ieia?/ii aeoeaieo ?a/iaei

1 2 3

1 Aooi?ioiiee iao?eo, UO?E

1 – ?ioaeoia a?oia

2 – oaa?eie c iao?eoii 0,2 ie o?c?ieia?/iiai ?ic/eio, 7 ae?a a/i.

3 – oaa?eie c iao?eoii 0,12 ia/ea PEKDSRK, 7 ae?a a/i

4 – oaa?eie c iao?eoii 0,12 ia/ea PEKDLRK, 7 ae?a a/i

5 – oaa?eie c iao?eoii 0,12 ia/ea PEKDDRL, 7 ae?a a/i

6 – oaa?eie c iao?eoii 0,12ia/ea IIEI, 7 ae?a a/i

2 Aooi?ioiiee iao?eo, OII”ssEE

1 – ?ioaeoia a?oia

2 – oaa?eie c iao?eoii 0,2 ie o?c?ieia?/iiai ?ic/eio, 7 ae?a a/i.

3 – oaa?eie c iao?eoii 0,12 ia/ea PEKDSRK, 7 ae?a a/i

4 – oaa?eie c iao?eoii 0,12 ia/ea PEKDLRK, 7 ae?a a/i

5 – oaa?eie c iao?eoii 0,12 ia/ea PEKDDRL, 7 ae?a a/i

6 – oaa?eie c iao?eoii 0,12ia/ea IIEI, 7 ae?a a/i

3 Ooi?enoa ?ioieneeaoe?y, UO?E

1 – ?ioaeoia a?oia

2 – eiio?ieueia a?oia 0,2 ie o?c?ieia?/iiai ?ic/eio, 7 ae?a a/i.

3 – eiio?ieueia a?oia 0,12 ia/ea IIEI, 7 ae?a a/i

4 Aino?a i?ooaiiy aoeeaiae?eieai, UO?E

1 – ?ioaeoia a?oia

2 – eiio?ieueia a?oia 0,2 ie o?c?ieia?/iiai ?ic/eio, 7 ae?a a/i.

3 – eiio?ieueia a?oia 0,12 ia/ea IIEI, 7 ae?a a/i

5 A?aeaeaeaiee oa?i?i i?ney io?oaiiy ao?eaia?eieai, OII”ssEE

1 – ?ioaeoia a?oia

2 – eiio?ieueia a?oia ii/?iath/? c 5 aeiae, 0,2 ie o?c?ieia?/iiai
?ic/eio, 7 ae?a a/i.

3 – eiio?ieueia a?oia 0,12 ia/ea PEKDSRK, 7 ae?a a/i

4 – eiio?ieueia a?oia 0,12 ia/ea PEKDLRK, 7 ae?a a/i

5 – eiio?ieueia a?oia 0,12 ia/ea PEKDDRL, 7 ae?a a/i

6 – eiio?ieueia a?oia 0,12ia/ea IIEI, 7 ae?a a/i

Aenia?eiaioaeueio iiaeaeue aooi?ioiiiai o?aaeaiiy ie?ie a?aeoai?thaaee
ca iaoiaeeeith Kment A., Hofescker G. [1976]. Aiaeii-nieueiaee aeno?aeo
ie?ie ci?ooaaee c aae’thaaioii O?aeiaea (1:1) aei ooai?aiiy no?eei?
aioeuen??, yeo aaiaeeee oaa?eiai aioo??oiueii’yciai a aeic? 0,2 ie o?e/?
c ?ioa?aaeii a 7 ae?a. Ii/eiath/e c 15 aeiae, oaa?ei ae?eeee ia a?oie:
ia?oa – ?ioaeoi? oaa?eie, ae?oaa – eiio?ieueia c aooi?ioiiei iao?eoii
(AI) oa aaaaeaiiiyi o?c?ieia?/iiai ?ic/eio, o?aoy – AI c aaaaeaiiyi
iaioeaeo PEKDSRK, /aoaa?oa – AI c aaaaeaiiyi PEKDLRK, i’yoa – AI c
aaaaeaiiyi PEKDDRL, oinoa – AI c aaaaeaiiyi i?e?iaeiiai iaioeaeiiai
eiiieaeno ie?ie (IIEI). O an?o aeine?aeao IIEI oa eiai neioaoe/i?
aiaeiae aaiaeeee o aeic? 0,12 ia/ea a 0,2 ie o?c?ieia?/iiai ?ic/eio.
Ii??aiyiiy i?iaiaeeee c a?oiiith ?ioaeoieo oaa?ei.

Aino?a oiene/ia o?aaeaiiy aoeeaiae?eieai aeeeeeaee oeyoii ia?i?aeueiiai
aaaaeaiiy eiai uo?ai a aeic? 1a/ea aaae o?ea. *a?ac aeiao oaa?ei
iiae?eyee ia 2 a?oie: – eiio?ieueio (aoeeaiae?eieue c ?iueaeoe??th
o?c?ieia?/iiai ?ic/eio) ? aeine?aeio (aoeeaiae?eieue c ?iueaeoe??th
IIEI) ia i?ioyc? 7 ae?a.

Iane?aeee oiene/iiai o?aaeaiiy aoeeaiae?eieai o a?aeaeaeaiee oa?i?i ?
o?c?ieia?/io ?ieue IIEI oa eiai neioaoe/ieo aiaeia?a aea/aee ia oii’yeao
oeyoii ia?i?aeueiiai aaaaeaiiy ?ic/eio aoeeaiae?eieth a aeic? 1a/ea aaae
o?ea. *a?ac 5 ae?a oaa?ei ?iciiae?eyee ia a?oie: 1-oa — ?ioaeoi?
oaa?eie, 2-aa — eiio?ieuei? (o?aaeaiiy aoeeaiae?eieai ? aaaaeaiiy
o?c?ieia?/iiai ?ic/eio), 3-y — o?aaeaiiy aoeeaiae?eieai ? aaaaeaiiy
iaioeaeo PEKDSRK, 4-oa — aaaaeaiiy iaioeaeo PEKDLRK, 5-oa — aaaaeaiiy
iaioeaeo PEKDDRL, 6-oa – i?e?iaeiee iaioeaeiee eiiieaen ie?ie.

Aino?o ?ioieneeaoe?th ooi?enoei iao???i ?iaeoeoaaee o uo??a oeyoii
aaaaeaiiy a oeoiie 3% ?ic/eio ooi?eaeo iao??th ?c ?ic?aooieo 250 ia/ea
iane o?ea [Aaoeei A.I., AEaai?iieia A.A., 1982]. *a?ac aeiao oaa?ei
iiae?e?ee ia 2 a?oie – eiio?ieueio (ooi?eae iao??th c aeiaeaaaiiyi
o?c?ieia?/iiai ?ic/eio) ? aeine?aeio (ooi?eae iao??th c aeiaeaaaiiyi
i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie).

Ia’?eoaie aeine?aeaeaiue aoee: e?ia aeiii??a oa oaa?ei, ne?iaaoea
e?ia?, oeaieie ie?ie, oeiono, ia/?iee, iiceo, iaaeie?iee?a, naeac?iee.

Aecia/aiiy O- oa A-e?ioioeeo?a o oaa?ei (cieioeno? oii’yee) i?iaiaeeee
iaoiaeii ?icaoeiooai?aiiy c aooieia?/ieie a?eo?ioeeoaie, iaaaioaaeaieie
aioene?iaaoeaie, ui aoee io?eiai? aei oeaiei oeiono oa e?ioaoe/ieo
aoce?a [O?eiaeue A. 1987].

Aecia/aiiy iaia?aiieo ia?ea?ia aeiii??a i?iaiaeeee iaoiaeii iai?yii?
oethi?anoeaioei? c iaeii/aniei eiio?ieai a oaciaiio eiio?anoi ia
iie?ineiii «Ethiai-?8» (EIII, ?iniy) [O?eiaeue A. 1987]. Eiioioeeoe
aeaeieyee c ia?eoa??/ii? e?iai, noaaieiciaaii? aaia?eiii, ia a?aae??io?
o?eie-aa?ia?ao?i (aonoeia 1.077a/ie). A?aeieo? e?ioioeeoe a ia’?i? 50
iee (eiioeaio?aoe?y 1o106/ie) ?ieoaoaaee 45 oaeeei i?e +40N c 5 iee
iiiieeiiaeueieo aioeo?e (IEA). Aeei?enoiaoaaee IEA ae?iaieoeoaa
?inoeoooo ?ioiieia?? IIC ?in?? aei ND-3, CD-4, CD-8, CD-72..
Niinoa??aaee caeaio oethi?anoeaioe?th. ?ic?aoiaoaaee na?aaei?e
oeeoio?i?/iee eiao?oe??io [Astald G., Verga L. 1957].

E?euee?nia aecia/aiiy ?IE oa AeIE a oeaieiao ie?ie i?iaiaeeee ca
iaoiaeii [O?oaeiethaiaa I.O. 1977], a iniiao yeiai iieeaaeaii aeae?eaiiy
ioeea?iiaeo eeneio c iine?aeiaiei aeeo/aiiyi eeneioi?ic/eiieo i?iaeoeo?a
a?ee?a ? e?i?ae?a eoaeiei (?IE) oa eeneioiei (AeIE) a?ae?ie?cii c
ianooiiei aecia/aiiyi iioe/ii? aonoeie i?e 260 ii (?IE), 290 ii (AeIE) a
ii??aiyii? c aenoeioe??th 270 ii ca oi?ioeith ((A270 — A290)/ 0,19)*
10,1.

Io?eiaiee oeeo?iaee iaoa??ae aoa noaoenoe/ii ia?iaeaiee ia IAII ?AI
?N/AO-286 “Omega”. I?iaiaeeee ia/eneaiiy na?aaeiuei? a?eoiaoe/ii? (I),
iiieeee na?aaeiuei? a?eoiaoe/ii? (i), a??ia?aeiinoue io?eiaieo
?acoeueoao?a ii eiao?oe??ioo No’thaeaioa (t).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

O a?aeiia?aeiino? ?c caaea/aie ?iaioe, iaie aoea aea/aia ae?y
i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie (IIEI) oa eiai neioaoe/ieo
aiaeia?a: i?i-aeo-e?c-ani-na?-a?a-e?c – PEKDSRK,
i?i-aeo-e?c-ani-eae-a?a-e?c – PEKDLRK, i?i-aeo-e?c-ani-ani-a?a-eae –
PEKDDRL ca o?c?ieia?/ieo oiia ? i?e a?aeoai?aii? ??cieo
aenia?eiaioaeueieo iiaeaeae.

IIEI, yeee aeae?eaiee ?c oeaieie ie?ie [Iaoaio], ia? ye iaaiiniaoeeo?/i?
aeanoeaino? — ii?iae?co? ooieoe?? ie?ie i?e ??cieo o?aaeaiiyo, oae ?
?ioiiiiaeoethth/o ae?th — aieeaa? ia O-ee?oeiiee eaioetha ?ioi?oaoo
[Aanieia E.Y., Eaeaeaoaa E.I.,1998].

A?aoiaoth/e io?eiai? aeai?, ie aeine?aeeee aeoeai?noue neioaoe/ieo
iaioeae?a o ii??aiyii? c IIEI. Aeey oeueiai noaaeee oanoe
?icaoei-ooai?thaaiiy c a?eo?ioeeoaie aa?aia oa ieo? ca iaoiaeeeith
E?aaae?aa E.I. oa Iaiye?ii? ?.Ae. [1990].

sse iieacaee iao? aeine?aeaeaiiy, ca o?c?ieia?/ieo oiia neioaoe/i?
aiaeiae aeoeaoaaee i?ioeane oaaioeeoico, i?iieneaeaioio oa i?ioaie?oe/io
ooieoe?? iaeo?io?e?a, i?e/iio PEKDLRK iaea?eueo i?aeneethaaa
eenaiue-aeoeaoth/o ooieoe?th iaeo?io?e?a, a PEKDSRK iaea?eueo ?noioii
i?aeneethaaa i?ioaie?oe/io aeoeai?noue.

Aoei anoaiiaeaii, ui neioaoe/i? iaioeaee aieeaaee ia ooieoe?iiaeueio
aeoeai?noue ?ioiieiiiaoaioieo ee?oei: ca?eueooaaee e?euee?noue A-?OE
oaio?e?i-/ooeeaeo ee?oei. Iaea?eueo aeoeaiei aeyaeany neioaoe/iee
iaioeae PEKDSRK, yeee ca?eueooaaa e?euee?noue A-?OE oaio?e?i-/ooeeaeo a
1,6 ?ace a?aeiinii iieaciee?a eiio?ieueii? a?oie, neioaoe/iee iaioeae
PEKDLRK — a 1,2 ?ace, ye ? IIEI, a neioaoe/iee iaioeae PEKDDRL — a 1,3
?ace. Aeine?aeaeai? iaie iaioeaee noeioethaaee oaaioeeoa?io aeoeai?noue
iaeo?io?e?a, iaea?eueo aeoeaiei aoa IIEI, ye?e i?aeneethaaa oaaioeeoa?io
aeoeai?noue a 1,8 ?ace. Iaioeaee PEKDDRL, PEKDSRK — a 1,7 oa 1,5 ?ace
a?aeiia?aeii. Ia iieacieee I-?OE ye i?e?iaeiee iaioeaeiee eiiieaen oae ?
eiai aiaeiae a??ia?aeiiai aieeao ia iaee.

Ie oaeiae aeine?aeeee aieea IIEI oa eiai neioaoe/ieo aiaeia?a ia
aeni?an?th iiaa?oiaaeo ?aoeaioi??a e?ioioeeo?a ca aeiiiiiaith ?aaeoe??
iai?yii? oethi?anoeaioe?? c aeei?enoaiiyi iiiieeiiaeueieo aioeo?e ND-4
i?ioe O-oaeia??a/?iaeoeoi??a, ND-8 i?ioe
O-noi?ani??a/oeeoioiene/ieo ee?oei, ND-3 i?ioe caaaeueieo O-ee?oei,
ND-72 i?ioe A-e?ioioeeo?a.

Aeyaeeinue, ui i?ae aieeaii IIEI oa eiai neioaoe/ieo aiaeia?a
niinoa??aaeenue ci?ie aeni?an?? niaoeeo?/ieo ?aoeaioi??a e?ioioeeo?a.
Noiniaii ND-3 ?aoeaioi??a ci?ie a?aeaoaaeenue a a?e ?o ca?eueoaiiy. Ia
aeni?an?th ND-4 ?aoeaioi??a iaioeaee ae?yee ??ciiiai?aaeaii. Iaioeaee
PEKDLRK oa PEKDDRL i?aeneethaaee aeni?an?th e?ioioeeo?a a 1,8 ? 2,3 ?ace
a?aeiia?aeii, a iaioeae PEKDSRK ? IIEI i?aeoe/ii ia cae?enithaaee aieeao
ia ?aoeaioi?iee aia?ao. Iaioeae PEKDLRK i?aeneethaaa aeni?an?th ND-8
?aoeaioi??a a 1,8 ?ace, ?io? iaioeaee ia aieeaaee ia aeni?an?th ND -8
?aoeaioi??a. Aieea iaioeaeo PEKDLRK ia aeni?an?th ND-72 ?aoeaioi??a
a?aeaoaaany aiaeia?/ii. O?eueee oeae iaioeae i?aeneethaaa aeni?an?th a
3,2 ?aca, a ?io? iaioeaee nooo?ai ia aieeaaee ia aeni?an?th ND-72
?aoeaioi??a e?ioioeeo?a.

Oe? ci?ie na?ae/aoue i?i caeaoi?noue IIEI oa eiai aiaeia?a aieeaaoe ia
ooieoe?iiaeueio aeoeai?noue O-ee?oei.

IIEI oa PEKDLRK cia/ii i?aeaeuoaaee i?ie?oa?aoe?th e?ioioeeo?a aeiii??a,
?iaeoeiaaio aioeaaiii ie?ee oa Eii-A.

E?oa?aoo?i? aeai? uiaei aoaeoeaiino? ae?? neioaoe/ieo iaioeae?a i?e
aooi?ioiieo i?ioeanao oa io?eiai? iaie ?acoeueoaoe i?i ?ioiio?iii?
aeanoeaino? aeine?aeaeaieo iaioeae?a iaa?oiooaaee iiaeaeueo?
aeine?aeaeaiiy.

sse aenia?eiaioaeueio iiaeaeue aoei aeei?enoaii iao?eo Oaeiaia, yeee
iaeneiaeueii iaaeeaeaiee aei iaia?aiicii? aeiia?oeiiao?? o ethaeae
[Ae?aiee A.I. 1989; Natori Y et al. 1987]. Aioeaaie, ui a?aeiia?aeathoue
ca ?icaeoie iao?eoo Oaeiaia, ?icoaoiaai? a eeoai/eia?e aacaeuei?e
iaia?ai?, u?oeia?e ea?ioe?. Aaeeeee ?ioa?an aeeeeea? iayai?noue
ia?ao?anii ?aaaoth/eo aioeaai?a a u?oeia?e ea?ioe? eaiaeueoe?a ie?ie oa
ei?eiai? ?a/iaeie oeiono [Bakler R.K. et al. 1987]. Iaoiaaiaoe/ia iniiaa
iaoieia?? iieyaa? a a?aioey?ieo a?aeeeaaeaiiyo ?ioiiaeiaoe?io G i?ae
ai?oae??i. Oe? aeai? aeia?a ocaiaeaeothoueny c iauiaeaai?ie
iia?aeiieaiiyie i?i oa, ui iaioeaee, ye? iiaeaeththoue ai?oii
O-ee?oeiiiai ?ici?ciaaaiiy, caeaoi? aaeueioaaoe ?icaeoie aooi?ioiieo
caoai?thaaiue [Eaeaeaoaa E.I. 1996].

I?ae /an aaaaeaiiy IIEI oa eiai neioaoe/ieo aiaeia?a aoei ca?a?no?iaaii
?noioi? ci?ie iieaciee?a ?ioi?oaoo o uo??a.

Iaioeae PEKDLRK noeioethaaa aeanoo?ainoi?iaoe?th e?ioioeeo?a oa
oaaioeeoa?io aeoeai?noue iaeo?io?e?a. Iaioeae PEKDSRK i?aeaeuoaaa
e?euee?noue a?eo?ioeeo?a, aaiiaeia?io, a oaeiae noeioethaaa
aeanoo?ainoi?iaoe?th e?ioioeeo?a ? oaaioeeoa?io aeoeai?noue iaeo?io?e?a.
Iaioeae PEKDDRL i?aeaeuoaaa e?euee?noue e?ioioeeo?a.

Eiao?oe??io iane ie?ie i?aeaeuoaaee iaioeaee PEKDLRK oa IIEI.
Neioaoe/iee aiaeia PEKDDRL ?noioii aieeaaa ia iano o?iono oa naeac?iee,
i?aeaeuoth/e ?o.

Aaaaeaiiy an?o iaioeae?a aeeeeeaei a ??ci?e i??? ii?iae?caoe?th
ii?oieia?/ii? no?oeoo?e ie?ie, iaea?eueo aeoeaieie aoee iaioeaee PEKDLRK
oa PEKDDRL.

Ianooiiei aaaeeeaei ieoaiiyi c oi/ee ci?o o?c?ieia?? oa ?ioiieia?? aoei
anoaiiaeaiiy aeaeiniaoeeo?/iino? ae?? o?c?ieia?/ii aeoeaieo ?a/iaei, ui
aeine?aeaeoaaeenue. Aeey oeueiai aoa ciiaeaeueiaaiee aooi?ioiiee iao?eo
ia oii’yeao.

?icaeoie aooi?ioiiiai i?ioeano ia oii’yeao i?ecaiaeea aei ii?ooaiiy
aioeieneaeaioiiai caoenoo, cieaeaiiy a?aenioea O-ee?oei a 1,4 ?ace,
cieaeaiith oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a a 1,5 ?ace oa aeoeaiino?
EEA a ieo a 1,1 ?ace. I?eaa?oa oaaao cieaeaiiy e?eueeino? ?ioiieo
eiiieaen?a o ne?iaaooe? e?ia? a 7,3 ?ace.

Iaioeaee, ye? ie aaiaeeee, ni?eyee ii?iae?caoe?? ii?ooaieo i?ioean?a.
IIEI i?aeaeuoaaa a?aenioie iiiioeeo?a a 17,5 ?ace ? ciaiooaaa
e?euee?noue aiceiio?e?a a 1,8 ?ace. Cieaeoaaa a?aenioie O- ? A-ee?oei oa
eiao?oe??io iane oeiono.

Anoaiiaeaii, ui ?aaoeyoi?i? iaioeaee ii?yae c ia?aiaith oa
aoii?aeueiith ?aaoeyoe??th iathoue ?ioiieia?/io ?aaoeyoe?th
o?c?ieia?/ieo ooieoe?e [Eociee A.E. oa ni?aaaoi?e 1998]. Aeiaaaeaii, ui
O-e?ioioeeoe ao?o/athoueny a i?ioeane ?aia?aoe?? ? ?aaaia?aoe?? oeaiei,
aenooiathoue ?aaoeyoi?aie a?eo?iiiaco, noeioethoue eaeeiiiac ?
o?iiaioeeoiiiac.

Ia aeeeth/aii, ui ?ioiieia?/ia ?aaoeyoe?y o?c?ieia?/ieo ooieoe?e
cae?enith?oueny i?e aaciina?aaei?e o/ano? a?ieia?/ii aeoeaieo ?a/iaei.

Aaaaeaiiy IIEI i?aeaeuoaaei oaaioeeoa?io aeoeai?noue iaeo?io?e?a a 1,5
?ace, a oaeiae e?euee?noue a ia?eoa?e/i?e e?ia? a?eo?ioeeo?a a 1,2 ?ace
oa ai?no aaiiaeia?io a ieo.

Neioaoe/iee iaioeae PEKDSRK ni?eya i?aeaeuaiith iano oii”ye?a a 1,4 ?ace
oa eiao?oe??ioo iane ie?ie, ca?eueooaaa oaaioeeoa?io aeoeai?noue
iaeo?io?e?a a 1,5 ?ace, ni?eya i?aeaeuaiith eiioeaio?aoe??
oee?eoethth/eo ?ioiieo eiiieaen?a a 4,6 ?ace, aieeaaa ia aaiiiiac,
i?aeaeuoth/e ia o?eueee e?euee?noue a?eo?ioeeo?a, a ? ai?no aaiiaeia?io
a ieo.

Iaioeae PEKDLRK ni?eya i?aeaeuaiith e?eueeino? eaeeioeeo?a a 1,3 ?ace.
C?inoaea oaaioeeoa?ia aeoeai?noue a 1,9 ?ace, e?euee?noue oee?eoethth/eo
?ioiieo eiiieaen?a i?aeaeuoaaeanue a 4,6 ?ace, c?inoaea iana oaa?ei a
1,3 ?aca. I?e oeueiio e?euee?noue a?eo?ioeeo?a ca?eueooaeanue, aea aac
aaeaeaaoiiai i?aeaeuaiiy ai?noo aaiiaeia?io.

Iaioeae PEKDDRL i?aeaeuoaaa a?aenioie aaeeeeo a?aioey?ieo e?ioioeeo?a a
1,6 ?ace, ciaiooaaa a 3,8 ?ace a?aenioie aic?iio?e?a a ia?eoa?e/i?e
e?ia?. Oaaioeeoa?ia aeoeai?noue iaeo?io?e?a i?aeaeuoaaeanue aei 44% a?ae
38,5% o eiio?ie?. Iaioeae ni?eya i?aeaeuaiith aeoeaiino? NIAe a 1,2
?ace. I?aeaeuoaaa ia o?eueee e?euee?noue a?eo?ioeeo?a, aea ? ai?no
aaiiaeia?io a ieo.

Oaeei /eiii, an? aea/ai? iaie iaioeaee aeyaeyee a?ieia?/io aeoeai?noue,
aea a ??ci?e i???. Iaea?eueo aeoeaiei aoa iaioeae PEKDDRL, eiai aoaeoe
nooo?ai ia a?ae??ciyeenue a?ae IIEI. I?eaa?oa? oaaao cae?ai?noue
iaioeae?a, ui aea/aeenue, aieeaaoe ia aaiiiiac, ii?ooaiee a oiiaao
ie?eiai? iaoieia??. Oea, iiaeeeai, na?ae/eoue i?i oa, ui oe? iaioeaee
caeaoi? aieeaaoe ia i?iaeoeoe?th a?eo?iiiaoei?a. E??i oiai, ? aaaeeeaei
oaeo, ui ie?ee o aioo??oiueioo?iaiiio ia??iae? aeeiiothoue aaiiiiaoe/i?
ooieoe??. C oeaiei ie?ie aei?ineeo i?aai?ci?a aoa aeae?eaiee iaioeae,
yeee ? o?aaiaioii aineeii-eaioethaa aaiiaeia?io [Eaeaeaoaa E.I. 1995,
1996].

Ii??aiyiiy a?ieia?/ii? aeoeaiino? IIEI oa eiai neioaoe/ieo aiaeia?a i?e
aooi?ioiiiio iao?eo? o uo??a oa oii’ye?a aeiaiaeeoue a?aenooi?noue o
oeeo a?ieia?/ii aeoeaieo ?a/iaei aeaeiniaoeeo?/iino?, ui i?aee?aneth?
caaaeueii – a?ieia?/io ?ieue oeeo ?a/iaei.

I?ae /an ?icaeoeo aooi?ioiii? a?aeiia?ae? ia ie?eia? aioeaaie (iao?eo
Oaeiaia) IIEI cieaeoaaa ?? i?iyae, ui ni?yiiaai? ia aioeaaie ie?ee,
iiaeeeai, oeyoii a?aeiiaeaiiy ?ioiieia?/ii? oiea?aioiino?.

Oaeei /eiii, io?eiai? iaie neioaoe/i? iaioeaee — PEKDSRK, PEKDDRL,
PEKDLRK — aiaeiae IIEI aoee caeaoi? aeieoaaoe ?icaeoie aooi?ioiiiai
iao?eoo, aea a ??ci?e i??? aeyaeyee ?ene o?c?ieia?/ii aeoeaieo ?a/iaei.

Iaie anoaiiaeaii aieea iaioeae?a ia ci?ie ii?oieia?/ieo no?oeoo? ie?ie
i?e iaaeineoue o?eaaeiio ?o aaaaeaii? oaa?eiai. Ii?iae?caoe?y ii?ooaieo
ooieoe?e caaacia/o?oueny ca ?aooiie a?ia?ieac?? oa aioo??oiueiee?oeiieo
?aaaia?aoi?ieo (a?ia?ieanoe/ieo) i?ioean?a.

?ioiia nenoaia ia? ooieoe?iiaeuei? ca’ycee c ?ioeie nenoaiaie
?acenoaioiino? e?ia? — eiaaoeyoe?eiith oa ia?aeeniei ieeneaiiyi e?i?ae?a
?acii ?c aioeieneaeaioiei caoenoii [Eociee A.A. oa ni?aaaoi?e 1989;
Aiea?aa E.I. oa ni?aaaoi?e 1989; Ieuaiei A.I. oa ni?aaaoi?e 1989], oiio
ie aeine?aeeee oe? i?ioeane a aenia?eiaio? oiene/iiai o?aaeaiiy
ooi?enoei iao???i.

Aeai? e?oa?aoo?e na?ae/aoue i?i oa, ui ooi?enoa ?ioieneeaoe?y
i?ecaiaeeoue aei o?aaeaiiy ie?ie, na?oey, noaeeiii? no?iee [AEe?iia A.A.
oa ni?aaaoi?e 1983; Iaaeaaa O.Ae. 1973; Iiainaeueoeaaa O.A. 1982;
O?ai/oe E.?. 1986], aeeeeea? oe?eee ?yae ii?oieia?/ieo, a?io?i?/ieo,
eiaaoeyoe?eieo oa ?ioiieia?/ieo ci?i a i?aai?ci? [Aioiiyi I.A. 1980;
Soni M.G. et al 1984]. Iaeiie/ai? oaeoe aeicaieythoue aaaaeaoe, ui a
iniia? oeeoioiene/iiai aieeao ooi?o eaaeeoue eiai caeaoi?noue
oiia?eueithaaoe neioac a?eeo o aoea??io?a oa noeioethaaoe i?ioeane
ia?aeeniiai ieeneaiiy e?i?ae?a a?ieia?/ieo iaia?ai [Ieoiaa A.I. oa
ni?aaaoi?e 1985].

Io?eiai? iaie aeai? na?ae/aoue i?i oa, ui ooi?enoa ?ioieneeaoe?y
i?ecaiaeeoue aei iioeiaeaeaiiy oeaiei ie?ie ca ?aooiie i?aeaeuaiiy IIE,
ui a?aeiia?aea? e?oa?aoo?iei aeaiei [Ieiaa A.I., AEe?iia A.A., 1985].
Oea noi?iaiaeaeo?oueny c?inoaiiyi aeoeaiino? noano?ao?iaeooeeaaeueiiai
oa?iaioo NIAe, a oaeiae cieaeaiiyi aeoeaiino? oea?oeiieaci?io. Oe? ci?ie
aoee ye a e?ia?, oae ? a oeaieiao ie?ee.

Aaaaeaiiy IIEI oaa?eiai c oiene/iei o?aaeaiiyi ooi?eaeii iao??th
aeyaeei oae? iniiai? ?ene ae??: aeieoaaiiy ciai?oiueiai oeyoo cn?aeaiiy
e?ia?, aeieoaaiiy o?iia?io oa aeoeaaoe?y o?a?eiie?co. Oe? aeanoeaino?
aeoaea aaaeeea? c oi/ee ci?o ooieoe?iiaeueiiai eieaeueiiai aaiinoaco
[Kanfer A. 1984, 1989, 1990].

I?ae aieeaii IIEI i?aeaeuoaaeanue ?acenoaioi?noue a?eo?ioeeo?a aei
ia?aeeniiai aaiie?co, cieaeoaaeenue ??aaiue OAE-aeoeaieo i?iaeoeo?a,
iaeiie/aiiy IAeA. A?aeiiaethaaeenue iieacieee aeoeaiino? oa?iaio?a AIC.
I/aaeaeii, cieaeaiiy ??aiy IIE a oeaiei? ie?ie i?ecaiaeeoue aei
ii?iae?caoe?? iaia?ai, a?aeiiaeaiiy i?ioean?a cn?aeaiiy e?ia?.

Ii?yae c ii?iae?coth/ei aieeaii ia i?ioeane IIE, IIEI cae?enithaaa
ei?aaoth/ee aieea ia i?ioeane aaiieiaaoeyoe??: iiaeiaaeoaaany /an
?aeaeueoeeo?eaoe??, i?io?iia?iiaee /an, AIO*.

A?iieiaaoeyoe?eiee aoaeo i?aia?aoo iaoiiaeaiee cieaeaiiyi ??aiy IIE a
e?ia? ? oeaiei? ie?ie [Ieuaiei A.I. 1987]. Iiae?aiee aoaeo iiaeeeaee ca
?aooiie aioeo?iia?io ???, yeee caaaaea? ooai?aiith i?io?iia?iace ?
o?iia?io.

Ianooiiei caaaeaiiyi, yea noiyei ia?aae iaie, aoei aea/aiiy ae?? IIEI
? eiai neioaoe/ieo aiaeia?a a oiiaao aino?iai io?o?iiy aoeeaiae?eieai oa
o a?aeaeaeai? no?iee oiene/iiai o?aaeaiiy. ?ioieneeaoe?y aoeeaiae?eieai
? oyaeeei io?o?iiyi, yea iineeth?oueny /a?ac oaeaeea aniieooaaiiy a e?ia
?c oeoieiai-eeoeiaiai o?aeoo. *a?ac e?eueea aiaeei a?aeaoaathoueny
ii?ooaiiy a ae?yeueiino? na?oeaai-noaeeiii? nenoaie, ie?ie, ia/?iee
[Oeiaiaiei E.E. 1977].

Ae?y IIEI i?ecaiaeeoue aei cieaeaiiy aaiie?co a?eo?ioeeo?a a 1,6 ?ace, a
??aaiue OAE-aeoeaieo i?iaeoeo?a aei ? i?ney ?ieoaaoe?? c?inoaa.
Cieaeoaaany ??aaiue aaoa-e?iii?ioa?ae?a ? ae??iiaeo eii’thaao, ui
noi?iaiaeaeoaaeiny ua a?eueoei cieaeaiiyi aeoeaiino? NIAe a 1,1 ?ace,
eaoaeace ? oea?oeiieaci?io a 1,3 ?ace. O oeaiei? ie?ee IIEI ca?eueoo?
??aaiue OAE-aeoeaieo i?iaeoeo?a aei ?ieoaaoe??, aea ciaioo? i?e??no
IAeA. Cieaeo?oueny aeoeai?noue NIAe.

Oe? aeai? a?aeiia?aeathoue aeine?aeaeaiiyi Cayaieuenueei? ?.I. [1998],
ui iie?iaioeaeiee i?aia?ao, yeee aeae?eaiee c oeaiei ie?ie, aieiae?a
a?i?aaoethth/ith ae??th, ii?iae?coaaa noai iieaciee?a nenoaie IIE .

O a?aeaeaeaiee oa?i?i oiene/iiai o?aaeaiiy aoeeaiae?eieai
niinoa??aaeenue iii??i?, aea no?ee? ii?ooaiiy ooieoe?e ie?ie. Aaaaeaiiy
iaioeae?a ni?eyei ciaioaiith iane o?ea a on?o a?oiao a?aeiinii
eiio?ieueieo oaa?ei, ui na?ae/eoue i?i ii?iae?caoe?th aeae?eueii?
ooieoe?? ie?ie. Aaaaeaiiy aenia?eiaioaeueiei oaa?eiai IIEI oa eiai
neioaoe/ieo aiaeia?a i?ecaiaeeei aei iineeaiiy i?iaeoeoe?? a?eo?ioeeo?a
oa aaiiaeia?io, ii?iae?coaaei iai?i ioeea?iiaeo eeneio oa ??aaiue
ia?aeeniiai ieeneaiiy e?i?ae?a a ia?aio?i? ie?ie i?ney oiene/iiai
o?aaeaiiy. Eiaeai c neioaoe/ieo iaioeae?a, ui aea/aeenue, iaa oa?aeoa?i?
iniaeeaino? ae??: PEKDSRK cae?enithaaa a?eo?iiiaoeiiiae?aio ae?th,
PEKDDRL aieeaaa ia eaeeiiiac oa aeoeai?noue eaeeioeeo?a, PEKDLRK
aeyaeany iaea?eueo aeeceei ii ae?? aei IIEI, ? a ?yae? aeiaaee?a aeyaeya
iaea?eueoo o?c?ieia?/io aeoeai?noue. Neioaciaai? iaioeaee-aiaeiae
iathoue aeanoeaino? iioaioe?eieo o?c?ieia?/ii aeoeaieo ?a/iaei aeey
i?io?eaeoeee iane?aee?a oiene/iiai o?aaeaiiy ie?ie.

A ie?eao ?nio? eieaeueia nenoaia iaioeaeii? ?aaoeyoe??, ui caaacia/o?
ii?iaeueia i?io?eaiiy iaoaaie?/ieo i?ioean?a, ?ioiieo ?aaeoe?e ?
i?aeo?eiaiiy aaiinoaco. Aiae?c aaiethoe?eiiai cia/aiiy a?ieia?/ii
aeoeaieo ?a/iaei [Eociee A.E. 1988; Neaiooeei A.Ae. oa ni?aaaoi?e 1987;
Noaiaiia I.A. 1988] aeicaiey? aenoiooe i?eiouaiiy i?i iayai?noue
iiae?aiiai i?eioeeio a?i?aaoeyoe?? ia an?o ??aiyo aeeai? iaoa???, ui
i?aeoaa?aeaeo? ?aei?noue ?aaoeyoi?ieo iaoai?ci?a a a?iaaiac?.

Oaeei /eiii, io?eiai? ?acoeueoaoe aeaiiino?othoue aca?iica’ycie i?ae
IIE, AIC, aaiinoacii ? ?ioiiith nenoaiith ui ooai?ththoue ?aeeio nenoaio
caoenoo i?aai?cio, yea a cia/i?e i??? iiaea aooe iiina?aaeeiaaia
a?ieia?/ii aeoeaieie ?a/iaeiaie. Nenoaia iie?iaioeae?a a?aeiiaeth? ia
o?eueee ooieoe?th, a ? no?oeoo?o iioeiaeaeaieo i?aai?a. Aaaeeeaith
aeanoea?noth i?e?iaeieo ?aaoeyoi??a, ui ?icaeyaeathoueny, ? ?o
caeaoi?noue aeaaaoe aoaeo a iecueeeo eiioeaio?aoe?yo. Iaioeaee ia
iaeiie/othoueny a i?aai?ci?, iaei oiene/i?. Ia iathoue oiene/iino? ?
i?iaeoeoe ?o iaoaaie?cio – ai?iieeneioe, aiaeia?/i? oei, ui
ooai?ththoueny i?e ?icuaieaii? oa?/iaeo a?ee?a [Aoia?ei E.I. oa
ni?aaaoi?e 1991; Iwersen L.L. et al. 1980; Martinez J.L. et al 1981].

Aeniiaee

I?e?iaeiee iaioeaeiee eiiieaen ie?ie oa eiai neioaoe/i? aiaeiae ca
o?c?ieia?/ieo oiia caeaoi? ?aaoethaaoe ooieoe?eiee noai eaeeioeeo?a.
Aeine?aeaeai? iaioeaee noeioeththoue oaaioeeoa?io aeoeai?noue
iaeo?io?e?a: i?e?iaeiee iaioeaeiee eiiieaen ie?ie – a 1,8 ?ace iaioeae
PEKDDRL – a 1,7, PEKDLRK a 1,5 ?ace. Aiie oaeiae ?aaoeththoue aeni?an?th
e?ioioeeoa?ieo ?aoeaioi??a ND- 3, 8, 72.

I?e?iaeiee iaioeaeiee eiiieaen ie?ie oa eiai neioaoe/i? aiaeiae a oiiaao
ii?ooaiiy aaiiiiaco, aiane?aeie ?icaeoeo aooi?ioiiiai iao?eoo,
aeyaeythoue a?eo?iiiaoeiiiae?aio aeoeai?noue, ca?eueooth/e e?euee?noue
a?eo?ioeeo?a oa ai?no aaiiaeia?io a ieo.

I?e?iaeiee iaioeaeiee eiiieaen ie?ie, oa eiai neioaoe/i? aiaeiae ca oiia
aooi?ioiiiai iao?eoo a?aeiiaeththoue noai ?ioiii? nenoaie oeyoii
aeieoaaiiy ?ioiii? a?aeiia?ae? ia oeaieii? aioeaaie ie?ie.

O?c?ieia?/ia aeoeai?noue i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa
neioaoe/ieo iaioeae?a PEKDDRL, PEKDLRK, PEKDSRK ia ia?
aeaeiniaoeeo?/iino? ca oiia aaaaeaiiy uo?ai, oii’yeai oa i?e aianaii? o
e?ia aeiii??a.

I?e ?iaeoeoaaii? aenia?eiaioaeueieo iiaeaeae, iia’ycaieo c ae?aaeaieie
ii?ooaiiyie cn?aeaiiy e?ia? (?ioieneeaoe?y aoeeaiae?eieai oa ooi?eaeii
iao??th ? aooi?ioiiee iao?eo), aeyaeaia o?c?ieia?/ia aeoeai?noue
i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa eiai neioaoe/ieo aiaeia?a,
ni?yiiaaia ia aeieoaaiiy o?iia?io, c?inoaiiy ??aiy aioeo?iia?io-???,
i?aeneeaiiy o?a?eiie?co.

A oiiaao ?iaeoeoe?? o oaa?ei aenia?eiaioaeueii? iaoieia?? c ae?aaeaieie
ii?ooaiiyie i?ioean?a a?eueii?aaeeeaeueiiai ieeneaiiy (ooi?enoa
?ioieneeaoe?y, aooi?ioiiee iao?eo) o?c?ieia?/ia aeoeai?noue i?e?iaeiiai
iaioeaeiiai eiiieaeno ie?ie oa eiai neioaoe/ieo aiaeia?a ae?aaeaeanue o
a?aeiiaeaii? ??aiy aioeieneaeaioieo oa?iaio?a (NIAe, eaoaeace) a
oeaieiao ie?ie oa cieaeaii? iaeiie/aiiy i?iaeoeo?a ia?ieneaeaoe?? (ai?no
IAeA, oa ae??iiaeo eii’thaao), oae? ae ci?ie a?aeaoaaeeny ? a e?ia?.

Ii??aiyeueiee aiae?c o?c?ieia?/ii? aeoeaiino? a?ieia?/ii aeoeaieo
?a/iaei, ui aeine?aeaeoaaeeny, aeiaiaeeoue, ui iaea?eueo aeoeaieie ?
iaioeaee: PEKDSRK, ye?e ia? ae?aaeaio iaoaaie?/io oa
a?eo?iiiaoei-iiae?aio ae?th, oa PEKDDRL, ye?e a?ae??ciy?oueny cia/ieie
?ioiio?iiieie aeanoeainoyie.

NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??:

1. Aaeei I.A., Aia?iaa I.A., Eaeaeaoaa E. I. N?aaieoaeueiia eco/aiea
aeoeaiinoe anoanoaaiiiai iaioeaeiiai eiiieaena ii/ae e aai neioaoe/aneeo
aiaeiaia i?e aooieiioiiii iao?eoa// Yenia?eiaioaeueiay e eeeie/aneay
oa?iaeieiaey.- 1998.- o.61, ?4.- N.44-47.

2. Aaeei I.A., Eaeaeaoaa E.I. Eco/aiea oa?aiaaoe/anee aeoeaiinoe
neioaoe/aneeo iaioeaeia – aiaeiaia anoanoaaiiiai iaioeaeiiai eiiieaena
ii/ae ia iaeioi?ua iieacaoaee aiiainoaca o oiiyeia i?e aooieiioiiii
iao?eoa// I?iaeaie ?eieia?? oa iaaeeoeeie.- 1997.-o. 1, ?1-2.- N.24-26.

3. Iiaeeiiaa I.A., Aaeei I.A., Aia?iaa I.A., Aiaiae/ I.A., ?yaaiei A.A.,
Aanieia E.Y., Aa?eiae/ A.E., Eaeaeaoaa E.I. Aeeyiea iaioeaeiiai
eiiieaena ia/aie ia i?ioeannu aiiioica a eeaoeao ia/aie,
eiaeooee?iaaiiua oao?aoei?iaoaiii// I?iaeaie ?eieia?? oa iaaeeoeeie.-
1998.- o.2, ?1-2.- N.4-7.

4. Aaeei I.A., Aaooiaaiei I.A., Cayaieueneay E.I., Eaeaeaoaaa Y.E., Eaae
I.A., Aa?eaei E.A. Ei??eae?othuaa aeaenoaea neioaoe/aneeo iaioeaeia –
aiaeiaia anoanoaaiiiai iaioeaeiiai eiiieaena ii/ae ia ninoiyiea
i?aaiecia e?un i?e aooieiioiiii iao?eoa// I?iaeaie ?eieia?? oa
iaaeeoeeie.- 1999.- o.3, ?1-2.- N.120-124.

5. Aaeei I.A. Aeeyiea anoanoaaiiiai iaioeaeiiai eiiieaena ii/ae e aai
neioaoe/aneeo aiaeiaia ia iaeioi?ua iieacaoaee eiioieoaoa e ia?aeeniiai
ieeneaiey/ Iaoa??aee eiioa?aioe?? iieiaeeo a/aieo “O?c?ieia?y ?
iaoieia?y ia?aeeniiai ieeneaiiy, aaiinoaco oa ?ioiiaaiaco”, i. Iieoaaa,
1998 ?.// I?iaeaie ?eieia?? oa iaaeeoeeie.- 1999.- o.3, ?1-2.- N.26-27.

6. Aaeei I.A., Eaeaeaoaa E.I., Cayaieueneay E.I., Aaooaaaiei I.A.,
Nieieaiei A.I., Aanieia E.Y., Aa?eaei E.A. Aeeyiea i?e?iaeiiai
iaioeaeiiai eiiieaena ii/ae e aai neioaoe/aneeo aiaeiaia ia yeni?anneth
iiaa?oiinoiuo ?aoeaioi?ia eeioioeeoia aeiii?ia// I?iaeaie ?eieia?? oa
iaaeeoeeie.- 1999.- o.3, ?3-4.- N.94-95.

Aaeei I.I. O?c?ieia?/ia aeoeai?noue i?e?iaeiiai iaioeaeiiai eiiieaeno
ie?ie oa eiai neioaoe/ieo aiaeia?a a oiiaao ii?ie oa i?e
aenia?eiaioaeueieo ?? ii?ooaiiyo. – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe
ca niaoe?aeuei?noth 03.00.13 – o?c?ieia?y ethaeeie oa oaa?ei. –
Oe?a?inueea aeaaeai?y aa?a?ieo iaoe, ?inoeooo naeia?noaa OAAI, Iieoaaa,
1999.

Aea/aia o?c?ieia?/ia aeoeai?noue i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie
(IIEI) oa eiai neioaoe/ieo aiaeia?a: PEKDSRK, PEKDLRK, PEKDDRL i?e
aianaii? a e?ia aeiii??a in vitro a oiiaao o?c?ieia?/ii? ii?ie oa
aooi?iioiiiai iao?eoo ia aeaio aeaeao oaa?ei, a oaeiae i?e ooi?eno?e
?ioieneeaoe?? oa o?aaeaii? aoeeaiaeeeieai. Oeacai? iaioeaee ia iathoue
aeaeiniaoeeo?/iino? ae??.

A e?ia? aeiii??a in vitro iaioeaee cae?enithaaee aieea ia O-ee?oeiio
eaieo ?ioi?oaoo. IIEI oa eiai neioaoe/i? aiaeiae ni?eyee ca?eueoaiith
aeni?an?? CD-3,4,8,72 iieaeoe ia iiaa?oi? e?ioioeeo?a, iineethaaee
i?ie?oa?aoe?th e?ioioeeo?a oa oaaioeeoa?io aeoeai?noue iaeo?io?e?a.

I?e aooi?ioiiiio iao?eo? iaioeaee aeieoaaee aooi?ioiio a?aeiia?aeue ia
aioeaaie, i?iyaeyee a?eo?iiiaoeiiiae?aio aeoeai?noue.

I?e ??cieo aeaeao ?ioieneeaoe?? aoeeaiae?eieai cae?enithaaee ?aaoeyoi?io
ae?th ia i?ioeane ?aaaia?aoe?? oa ?aia?aoe??, ii?iae?coaaee
eiaaoeyoe?eiee iioaioe?ae e?ia?, iai?i ioeea?iiaeo eeneio oa i?ioeane
ia?aeeniiai ieeneaiiy e?i?ae?a a oeaieiao ie?ie. Ca oiia ?ioieneeaoe??
ooi?enoei iao???i a?aeiiaethaaee iieacieee aaiinoaco.

Oaeei /eiii, iaioeaee ie?ie iathoue aaaeeeaa cia/aiiy a i?aeo?eioe?
o?c?ieia?/iiai noaio ie?ie oa oe?e?niiai i?aai?cio.

Eeth/ia? neiaa: iaioeaee, ie?ee, o?c?ieia?/ia aeoeai?noue, a?eueii-
?aaeeeaeueia ieeneaiiy, ?ioi?oao, aaiinoac.

Aaeei I.A. Oeceieiae/aneay aeoeaiinoue i?e?iaeiiai iaioeaeiiai eiiieaena
ii/ae e aai neioaoe/aneeo a ii?ia e i?e yenia?eiaioaeueiuo aa
ia?ooaieyo. – ?oeiienue.

Aeena?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe
ii niaoeeaeueiinoe 03.00.13 – oeceieiaey /aeiaaea e aeeaioiuo. –
Oe?aeineay aeaaeaiey aa?a?iuo iaoe, Einoeooo naeiiaiaenoaa OAAI,
Iieoaaa, 1999.

Eco/aia oeceieiae/aneay aeoeaiinoue i?e?iaeiiai iaioeaeiiai eiiieaena
ii/ae (IIEI) e aai neioaoe/aneeo aiaeiaia: PEKDSRK, PEKDLRK, PEKDDRL i?e
aianaiee a e?iaue aeiii?ia in vitro, a oneiaeyo aooieiioiiiai iao?eoa ia
e?unao e oiiyeao. I?e ooi?enoie eioieneeaoeee e ii?aaeaiee
yoeeaiaeeeieai.

I?e aianaiee a e?iaue aeiii?ia in vitro a oanoao ?icaoeiia?aciaaiey
iaioeaeu ieacuaaee ooieoeeiiaeueioth aeoeaiinoue ia eiioiieiiiaoaioiua
eeaoee, oaaee/eaaee eiee/anoai A-?IE oaioeeei-/oanoaeoaeueiuo eeaoie e

aeoeaiinoue eeciniiaeueiuo eaoeiiiuo aaeeia a iaeo?ioeeueiuo
eaeeioeeoao. Iieacaoaee I-?IE i?aeoe/anee ia iaiyeenue. Eiee/aneoai
A-?IE oaioeeei-?acenoaioio oiaiueoaeinue. IIEI e aai neioaoe/aneea
aiaeiae ieacuaaee naia aeeyiea ia O-eeaoi/iia caaii eiioieoaoa e
i?aeoe/anee ia aeeyee ia A-eeioioeeou.

Enneaaeoy aeeyiea IIEI e aai neioaoe/aneeo aiaeiaia ia yeni?anneth
iiaa?oiinoiuo ?aoeaioi?ia eeioioeeoia, auyaeee, /oi aeaiiua
oeceieiae/anee aeoeaiua aauanoaa aeeytho ia yeni?anneth iiaa?oiinoiuo
ia?ea?ia eeioioeeoia. Eco/aiea i?iaiaeeeinue n iiiiuueth ?aaeoeee
iai?yiie eiioiioethi?anoeaioeee n eniieueciaaieai iiiieeiiaeueiuo
aioeoae CD-3 i?ioea iaueo O-eeioioeeoia, CD-4 i?ioea
O-oaeia?ia/eiaeoeoi?ia, CD-8 i?ioea O-noi?anni?ia/oeeoioiene/aneeo
eeaoie, CD-72 i?ioea A-eeioioeeoia.

Onoaiiaeee, /oi aaiaeeiua iaioeaeu niinianoaiaaee oaaee/aieth
yeni?annee CD-3,4,8,72 iieaeoe ia iiaa?oiinoe eeioioeeoia. A oae aea
oneeeaaee i?ieeoa?aoeeth eeioioeeoia, eiaeooee?iaaiioth Eii-A e
aioeaaiii ii/ee. IIEI e aai aiaeiae ieacuaaee onoie/eaue yooaeo ia
iieacaoaee oaaioeeoa?iie aeoeaiinoe iaeo?ioeeia a noi?iio iiauoaiey.

Aeey eco/aiey oeceieiae/aneie aeoeaiinoe iaioeaeia ii/ae, iai?aaeaiiie
ia ?aaoeyoeeth aeoeaiinoe eiioiiie nenoaiu, auea aua?aia iiaeaeue
aooieiioiiiai iao?eoa. A aini?iecaaaeaiea aai ia oiiyeao e e?unao, a oae
aea i?e aianaiee a e?iaue aeiii?ia i?iaaaeaii aeey onoaiiaeaiey
aeaeiniaoeeoe/iinoe aeaenoaey iaioeaeia ii/ae.

Eco/aaiua iaioeaeu aeiee?iaaee aooieiioiiue ioaao ia oeaiaaua aioeaaiu
ii/ae, iaania/eaay oeceieiae/aneoth eiioiieiae/aneoth oiea?aioiinoue.
Noeioee?iaaee oaaioeeoa?ioth aeoeaiinoue iaeo?ioeeia, i?iyaeyee
y?eo?iiiyoeiiiaeiaioth aeoeaiinoue, oaaee/eaay /enei y?eo?ioeeoia e
aaiiaeiaeia a ieo.

Ia i?iyaeyee aeaeiniaoeeoe/iinoe aeaenoaey i?e aianaiee a e?iaue
aeiii?ia e i?e i?iaaaeaiee enneaaeiaaiee ia ?aciuo aeaeao aeeaioiuo.

Iaioeaeu ii/ae ieacuaaee ?aaoeyoi?iia aeaenoaea ia i?ioeannu
?aaaia?aoeee e ?aia?aoeee i?e ?acee/iuo aeaeao eioieneeaoeee
yoeeaiaeeeieai. Ii?iaeeciaaee eiaaoeyoeeiiiue iioaioeeae e?iae.
Niinianoaiaaee nieaeaieth niiioaiiiai aaiieeca y?eo?ioeeoia, aeoeaiinoe
noia?ieneaeaeeniooacu, nieaeaee o?iaaiue oea?oeiieacieia e i?ioeaio
i?e?inoa iaeiiiaiai aeeaeueaeaaeaea a oeaiyo ii/ae. Iaioeaeu PEKDSRK,
PEKDLRK e IIEI ii?iaeeciaaee iaiai ioeeaeiiauo eeneio e i?ioeannu
ia?aeeniiai ieeneaiey eeieaeia a oeaiyo ii/ae.

Ooi?enoay eioieneeaoeey aucuaaea a?oaua ia?ooaiey i?ioeannia ia?aeeneiai
ieeneaiey eeieaeia e aioeieneaeaioiie caueou. ?acaeoeeth
aeia?eiaaoeyoeee ia oiia nieaeaiey aioeeiaaoeyioiie aeoeaiinoe e
aeoeaiinoe oa?iaioia oea?eiieeoe/aneie nenoaiu.

IIEI oaaee/eaae aeoeaiinoue aioeo?iiaeia ???, a?aiy ?aeaeueoeeoeeaoeee e
o?iiaeiiaia a?aiy. O/anoaiaae a iiaeaea?aeaiee o?iaiy ia?aeeniiai
ieeneaiey eeieaeia e aioeieneaeaioiie caueou a oeaiyo ii/ae.

Oaeei ia?acii, iaioeaeu ii/ae eiatho aaaeiia cia/aiea a iiaeaea?aeaiee
oeceieiae/aneiai ninoiyiey ii/ae e oeaeinoiiai i?aaiecia.

Eeth/aaua neiaa: iaioeaeu, ii/ee, oeceieae/aneay aeoeaiinoue, naiaiaeii
?aaeeeaeueiia ieeneaiea, eiioieoao, aaiinoac.

Geico O.A. “Physiological activity of natural peptide complex of the
kidneus and its synthetic analogs im autoimmune and toxic viclations of
kidneys”. Manuscript.

The dissertation on completition of a scientific degree of the Candidate
of Biological scinces on a speciality 03.00.13 – Human and Animals
Phisiology.- Ukrainian academy of agrarian sciendes, Poltava Research
Institute for pig-breeding. Poltava, 1999.

Ihere was studied physiological activity of natural peptide complex of
kidneys (NPCK) and its syntetic analoges PEKDDRL, PEKDLRK, PEKDSRK in
intcoducing into the donor’s blood in vitro in condition phisiologycal
norma and of autoimunic nephritis on two spectes of animals as well as
in fluoride intoxication and ethyleneglycol.

When intkoducing into the donor’s blood in vitro in tests of
rosulaformation peptides revealed their functional activity on the
immunocompetent cell.

NPCK and its syntetic analogys assist in increasing of expression
CD-3,4,8,72 molecules on the surface of lymphocytes, strenthen
lymphocytes proliferation and ed phagocytic activity of neutrophiles.

Peptides blocked the autoimmunic response an antigenes, displayed
erythropoietinslike activity.

The kidneys peptide fulfil regulation in the process regeneration and
reparation in different types of intoxication. They normaliget
coagulative potential of blood. Normalised metabolisms of nucleic acids
and processes of lipid peroxidation in the tissues of kidneys.

Fluoride intoxication caused disturlances in the processes lipid
peroxidation, antioxidant protection and hemostasis.

Thus, peptides of kidneys have the important significance in supporting
of physiological condition of kidneys and the body entierly.

Key words: peptides, kidneys, phisiological activity, free radical
oxidation, immunity, hemostasis.

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