.

Фактори ризику ускладненого перебігу пневмонії та хронізації бронхолегеневого процесу у дітей: Автореф. дис… канд. мед. наук / О.Л. Говдалюк, Крим.

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I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i.N.?.Aai?a??anueeiai

Aiaaeaethe Ieaenaiae? Eaiiiaeiae/

OAeE 616.24-053.2/.6: 575.21:612.017.1:612-015.13:678.048

Oaeoi?e ?eceeo oneeaaeiaiiai ia?aa?ao iiaaiii??

oa o?ii?caoe?? a?iioieaaaiaaiai i?ioeano o ae?oae

14.01.10 – iaae?ao??y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

N?ioa?iiieue – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i.N.?.Aai?a??anueeiai I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie

Iaoeiaee ea??aiee – Eiaaoeue Oaoyia Aieiaeeie??aia, aeieoi? iaaee/ieo
iaoe, E?einueeee aea?aeaaiee iaaee/iee oi?aa?neoao
?i.N.?.Aai?a??anueeiai, i?ioani? eaoaae?e aini?oaeueii? iaae?ao???

Iiaa?nueea Aaeaioeia Ieaenaiae??aia, aeieoi? iaaee/ieo iaoe, noa?oee
iaoeiaee ni?a?ia?oiee, canooiiee aee?aeoi?a ii iaoeia?e ?iaio?
Oe?a?inueeiai IAe? aeeoy/i? eo?i?oieiaii oa oiciioa?aiii

Oea/aiei THe?e Iao?iae/, aeieoi? iaaee/ieo iaoe, i?ioani?, caa?aeoaa/
eaoaae?e aini?oaeueii? iaaeiao?i? Caii??cueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo

I?ia?aeia onoaiiaa: Oe?a?inueeee IAe? ioi?iie caei?ia’y ae?oae oa
i?aee?oe?a, a?aeae?eaiiy aioo??oiuei? iaoieia??, IIC Oe?a?ie, i. Oa?e?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny 25 n?/iy 2000 ?. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 52.600.01 i?e E?einueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? ?i. N.?. Aai?a??anueeiai Iic Oe?a?ie (
95006i.N?ioa?iiieue, aoe.Eai?ia 5/7)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? E?einueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?. Aai?a??anueeiai (
95006i.N?ioa?iiieue, aoe.Eai?ia 5/7)

Aaoi?aoa?ao ?ic?neaiee 22 a?oaeiy 1999 ?.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee

Ae.i.i., i?ioani?
I.O.Iaco?aoeue

Caaaeueia oa?aeoa?enoeea ?iaioe.

Aeooaeuei?noue oaie. Iacaaeath/e ia oni?oe a e?eoaaii? ?anii?aoi?ieo
caoai?thaaiue, iiaaiiiiy ? o?ii?/ia a?iioieaaaiaaa iaoieiaiy o ae?oae
caa??aathoue aenieo aeooaeuei?noue aeey Oe?a?ie. oea coiiaeaii aenieith
caoai?thaai?noth, oaiaeaioe??th aei oneeaaeiaiiai, caoyaeiiai,
?aoeeaeeaoth/iai ia?aa?ao aino?eo i?ioean?a, ui ana /ano?oa noathoue
i?e/eiith oi?ioaaiiy o?ii?/ii? iaoieiaii c? no?eeeie a?aeoeeaiiyie noaio
caei?ia’y ae?oae (Iinoiaee TH.I., 1998). Ca inoaii?ie aeaieie, eeoa 10 %
o?ii?/ieo a?iioieaaaiaaeo caoai?thaaiue coiiaeai? i?e?iaeaeaiith oa
niaaeei?iiith iaoieiai?th (?iciiiaa I.I., 1999). Oea aeiaaa? ?ic?iaee ia
o?eueee iiaeo cania?a e?eoaaiiy, aea e iiaeo cania?a ae?aaiinoeee, ui
aeicaieyoue i?iaiicoaaoe ?icaeoie oa oneeaaeiaiee ia?aa?a iiaaiiiii ia
?aii?o aoaiao ?icaeoeo aeeoeie.

Oey i?iaeaia ia? ? nioe?aeueia cia/aiiy, ai c oai?eie ae?oueie ciooai?
ciaoiaeeoeny iaoa?i, ui i?ecaiaeeoue aei ae?iaie/eo caeoe?a c oei/aniai?
iai?aoeacaeaoiino?.

Aeooaeueiei caeeoa?oueny ieoaiiy i?i cia/aiiy aiaeiaaiieo oaeoi??a
(noaio iioiii? nenoaie, nenoaie i?ioaieico, ia?aeeniiai ieeneaiiy
eiiiae?a (IIE)) a ?icaeoeo ? ia?aa?ao iiaaiiii? (Eioei I.I., Iiiiae/
TH.TH., 1998; Eoaeoe?i A.A. c ni?aaao., 1998). Ia?ae?/ai? nenoaie ?
iniiaieie eiiiiiaioaie, ui aa?ooue o/anoue a iaoiaaiac? a?iioieaaaiaaeo
caoai?thaaiue, ai /a?ac ieo iiina?aaeith?oueny ae?y ?ioaeoe?eiiai
aaaioa, ?ioeo enaiiaaiieo /eiiee?a, a oaeiae aiaeiaaiieo ee?oeiieo ?
aoii?aeueieo oaeoi??a, ui ooieoe?iiothoue ye naiiaaiaoe/ii, oae ?
iaoiaaiaoe/ii.

I?ioaacii-aioei?ioaacia nenoaia (IAN) ? ieneaeaioii-aioeieneaeaioia
(IAI) nenoaia aa?ooue o/anoue a ooeiaeaeaii? niieo/iioeaieiiiai ea?eana
eaaaiue, ?o ia?aioiie, no?oaeoaioa, ae?eicaiiiiae?eai?a, aecia/ath/e
?icaeoie aeano?oeoei?, a iaaeae? – oia?ica, aioicaie, a?iioiaeoac?a.
A?aeiii, ui ia ia?aa?a a?iioieaaaiaai? iaoieiai? ?noioii aieeaathoue
oaiioeiiai aa??aioe -1-iiaiaioi?a i?ioaiiac (-1-?I), aeyaeyth/enue a
aeayeeo aeiaaeeao i?ia?aeiei /eiieeii iaoiaaiaco (Eaiiinueea A.I.,
1978).

Aaaaoioaeoi?i?noue iiaaiiiii ? o?ii?/ieo ianiaoeeo?/ieo caoai?thaaiue
eaaaiue (OICE) aecia/a? aeooaeuei?noue eiiieaeniiai i?aeoiaeo ? aea/aiiy
i?noeaaiai ai?noo -1-?I, ?ioeo eiiiiiaio?a IAN oa IAI, noaio iioiii?
nenoaie, ui neeaaeathoue oaiioei eiie?aoiiai iiaeeaiaeooia, ?c
i?iaeoe??th iaea?aeaieo ?acoeueoao?a ia oae? aeinooii? aaii? ia?ea?e, ye
a?oie e?ia?, a?aoiaoth/e iayai?noue aaiaoe/iiai eiiiiiaioo a noeeueiino?
(aai no?eeinoi) ae?oae aei ianiaoeeo?/ieo caiaeueieo caoai?thaaiue
eaaai?a. A inoaii? ?iee aeyaeaii ca’ycie i?ae noaiii ie?aieo caoenieo
nenoai ? oaiioeiii aeeoeie (Eiaaoeue O.A., 1998), i?ioa, aca?iica’ycie
i?ae noaiii iioiioaoo, ia?aeeniiai ieeneaiiy eiiiae?a, i?ioaieico ?
oaiioeiii ae?oae ia aea/aany. Iiae?aia aeine?aeaeaiiy iiaea aooe
ia?niaeoeaiei, ai i?e aeyaeaii? oaeiai ca’yceo aoaea iaea?aeaia
iiaeeea?noue i?iaiicoaaiiy ii?ooaiue a oeeo nenoaiao ca oaiioeiii
aeeoeie ?c iiiaioo ia?iaeaeaiiy, ine?eueee oae? aaii? ia?ea?e ye a?oie
e?ia? ia ci?iththoueny i?ioyaii onueiai aeeooy. Oea aeicaieeoue ia
o?eueee i?iaiaeeoe oe?eani?yiiaai? i?io?eaeoe/i? caoiaee a a?oiao
?eceeo, aea ? i?ecia/aoe aaeaeaaoio oa?aiith i?e caoai?thaaii? aeeoeie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie. Aeena?oaoe?eia ?iaioa
aeeiioaaeany a ?aieao iaoeiai? i?ia?aie E?einueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo (EAIO) ?i. N.?. Aai?ai?anueeiai: “?ic?iaeoe iia?
i?aeoiaee aei ae?aaiinoeee, i?io?eaeoeee ? e?eoaaiiy caiaeueieo
caoai?thaaiue eaaaiue o ae?oae ia iniia? aea/aiiy ooiaeaiaioaeueieo
iaoai?ci?a ?o oi?ioaaiiy, oe?eani?yiiaaii? ei?aeoei? ooieoe?? eaaaiue”,
iiia? aea?aeaaii? ?a?no?aoe?? 01.95. U010153.

Iaoa aeine?aeaeaiiy: aecia/eoe oaeoi?e ?eceeo oneeaaeiaiiai ia?aa?ao
iiaaiiii? oa o?iiicaoei? a?iioieaaaiaaiai i?ioeano o ae?oae.

Caaea/? aeine?aeaeaiiy.

1. Aeaoe ee?i?/io oa?aeoa?enoeeo ae?oae ?c aino?ith iiaaiiii?th aac
oneeaaeiaiue, ?c aeano?oeoeaiith iiaaiiii?th oa c o?ii?/ieie
ianiaoeeo?/ieie caoai?thaaiiyie eaaaiue ?c o?aooaaiiyi a?oi e?ia?
ae?oae.

2. Aecia/eoe ca’ycie i?ae iniaeeainoyie ia?aa?ao iiaaiiii? o ae?oae ?
noaiii ie?aieo eaiie iioiioaoo a ??ci? a?eia? ia??iaee.

3. Aeyaeoe oaeoi?e ?eceeo oneeaaeiaiiai ia?aa?ao iiaaiiii? ? o?iiicaoei?
a?iioieaaaiaaiai i?ioeano a nenoaiao i?ioaieico ? a?eueii?aaeeeaeueiiai
ieeneaiiy.

4. Aeyaeoe ca’ycie i?ae iieacieeaie, ui aeine?aeaeothoueny ? aeayeeie
oaiioeiiaeie oa?aeoa?enoeeaie ae?oae ?c o?aooaaiiyi a?eiaeo
iniaeeainoae.

Iaoeiaa iiaecia. Eiiieaeniee iaoiaeieia?/iee i?aeo?ae aei aea/aiiy
iiaaiiii? ? OICE, – caoai?thaaiue ianiaaeei?iiiai iioiaeaeaiiy, o ae?oae
a ??ci? a?eia? ia??iaee, ui i?noeoue iaeii/ania aea/aiiy ee?i?/ieo
aeaieo, a?io?i?/ieo ? iioiieia?/ieo iieaciee?a, aeicaieea aeyaeoe
/eiieee ?eceeo oneeaaeiaiiai ia?aa?ao iiaaiiii? ? o?iiicaoei?
a?iioieaaaiaaiai i?ioeano a nenoaiao i?ioaieico, a?eueii?aaeeeaeueiiai
ieeneaiiy (A?I), iioiioaoo.

I?iaaaeaia aeine?aeaeaiiy aeicaieeei iieacaoe, ui aino?a iiaaiiiiy
iae/ano?oa ?icaeaa?oueny o ae?oae a ?aiiueiio a?oe? c a?oiith e?ia?
B(III), o oeii/ee?a /ano?oa, i?ae o ae?a/ao. I?ioa o?iiicaoe?y
a?iioieaaaiaaiai i?ioeano iae/ano?oa niinoa??aa?oueny o ae?a/eiie c
a?oiith e?ia? B(III), Rh+, ui aeicaieeei iai aaaaeaoe a?oio e?ia?
B(III), Rh+ ? ae?ii/o noaoue, i?e ?icaeoeo iiaaiiii?, iniaeeai a
?aiiueiio a?oe?, oaeoi?ii ?eceeo o?iiicaoei? i?ioeano.

Aia?oa aeyaeaii, ui o ae?oae, oai?eo ia iiaaiiiith, c a?oiith e?ia?
B(III) a ?aiiueiio a?oe? niinoa??aathoueny iaeieae/? iieacieee
O-eiioioeeo?a (O-e), O-oaeia??a (O-o), a oe?eueiiio – a?eueo cia/oua
cieaeaiiy Ig A o ii??aiyii? c oai?eie c 0(I), A(I?), AB(IV) a?oiaie
e?ia?. Iieacaii, ui o ae?a/aoie, a ii??aiyii? c oeii/eeaie, ieae/a
??aaiue ne?iaaoeiaeo iioiiaeiaoeii?a, a oaeiae a?eueo ae?aaeaia
cieaeaiiy -2-iae?iaeiaoeiio (-2-IA) a a?iioiaeueaaiey?iiio nae?ao?
(AAN), oaiaeaioe?y aei a?eueo aenieeo cia/aiue ia?aeiieo ? aoi?eiieo
i?iaeoeo?a ia?aeeniiai ieeneaiiy eiiiae?a, ui ni?ey? o?iiicaoei?
a?iioieaaaiaaiai i?ioeano.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeae?eaii oaeoi?e ?eceeo c
?icaeoeo aeano?oeoei? ? o?iiicaoei? a?iioieaaaiaaiai i?ioeano o ae?oae.
Anoaiiaeaii iaiao?aei?noue ?aaa?e?oaoe?? aioei?ioaacii?,
aioeieneaeaioii? oa iioiii? nenoai i?e caiaeueieo caoai?thaaiiyo eaaaiia
o ae?oae. Cai?iiiiiaaii aeei?enoiaoaaoe a yeino? i?iaiinoe/ieo e?eoa???a
i?e iiaaiiii? o ae?oae noaoue, a?e, a?oio e?ia? aeeoeie aac
aeiaeaoeiaiai i?iaaaeaiiy iaoiae?a aeine?aeaeaiiy, ye? aei?iai
eiooothoue, ui ia? ?noioia aeiiii?/ia cia/aiiy. Aeya ca’yceo i?ae oeeie
iieacieeaie oa noaiii ie?aieo eaiie ?ioiioaoo, i?ioaieico ? ia?aeiniiai
ieeneaiiy eiiiae?a aeicaiey? e?eoaaoe aeeoeio ?iaeea?aeoaeueii, a ia
oai?iao a oe?eiio, i?iaiicoaaoe oneeaaeiaiee ia?aa?a caoai?thaaiiy,
aeeth/aoe a e?eoaaiiy aaeaeaaoio iaoiaaiaoe/io oa?aiith, oe?eani?yiiaaii
i?iaiaeeoe eo?n i?io?eaeoe/ieo caoiae?a.

Iniaenoee aianie caeiaoaa/a. ?iaioa aeeiiaia ia aac? ioeueiiiieia?/iiai,
o??o?a?/iiai, ?aaiiiaoe?eiiai a?aeae?eaiue ?AeEE i. Niioa?iiiey,
aeeoy/iai a?aeae?eaiiy Oe?EE Niioa?iiieuenueeiai ?aeiio. Aeine?aeaeaiiy
i?iaiaeeeeny ia aac? eaai?aoi??? a?io?i?/ii? aaiaoeee ?AeEE,
iioiieia?/ii? eaai?aoi??? e?ea?i? ?8 i. Niioa?iiiey (caa. eaa. Iaeniiiaa
O.A.), OeIAeE EAeIO ?i. N.?. Aai?ai?anueeiai (caa. eaa. ae.i.i. Eoaeoeii
A.A.).

Ianoaaeaiiy oai?eo, iniiaiee ia’?i eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy,
noaoenoe/ia ia?iaea ?acoeueoao?a, ?o aiae?c aeeiiai? aaoi?ii naiino?eii.
Aaoi?ii aeieacaia a??ia?aei?noue ca’yceo ci?i a nenoaiao i?ioaieico,
IIE, iioiioaoo c oa?aeoa?ii ia?aa?ao caiaeueiiai i?ioeano a eaaaiyo ?
?iaeea?aeoaeueieie iniaeeainoyie aeeoeie.

Ai?iaaaeaeaiiy ?acoeueoao?a ?iaioe a i?aeoeeo. ?acoeueoaoe
aeine?aeaeaiue oi?iaaaeaeai? a ee?i?/io i?aeoeeo i?nueei? aeeoy/i?
e?ea?i? i. ?aiaoi???, ?AeEE i. Niioa?iiiey.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ?iaioe aeeeaaeaii ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo a i. Oa?eia? (Oa?e?a, 1995, 1997), i.
Aeooo? (Aeoooa, 1997), ia e?ea?nueeeo eiioa?aioe?yo a naiaoi??yo E?eio
(?aiaoi??y, 1997, sseoa, 1997); ia Aei? iaoee eaoaae?e aini?oaeueii?
iaaeiao?i? EAeIO ?i. N.?. Aai?ai?anueeiai (Niioa?iiieue, 1997); ia
i?aeia?iaeieo eiia?anao: c iioiieiai? (Iineaa, 1997), c oi?o?ai?
(Oaeue-Aaia, 1998). Iniiai? ?acoeueoaoe ai?iaiaai? ia i?aeeaoaae?aeuei?e
eiioa?aioe?? EAeIO ?i. N.?. Aai?ai?anueeiai (Niioa?iiieue, 1999).

Ioae?eaoei?. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o, na?aae
ieo – 1 noaooy a iaoeiaiio aeo?iae?, aea? ?iaioe a ca??eao iaoeiaeo
i?aoeue, oace a iaoa??aeao c’?cae?a ? eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??. ?iaioa neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, 4 ?icae?e?a aeanieo aeine?aeaeaiue, iai??eoaaiiy
?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo e?oa?aoo?e,
yeee aeeth/a? 195 aeaea?ae, iioae?eiaaieo a NIAe, ? 93 ca?oa?aeieo
aeaea?aea e?oa?aoo?e. Aeena?oaoe?y aeeeaaeaia ia 131 noi??ieao, i?noeoue
24 oaaeeoe?, 4 iaethiee.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

Aeey ?ica’ycaiiy iinoaaeaieo caaaeaiue aoei ianoaaeaii 144 aeeoeie
e?einueei? iiioeyoei? neia’yinueeeo iaoe?iiaeueiinoae a a?oe? a?ae 1 aei
14 ?ie?a, a /enei yeeo aoiaeeei 54 oai?eo ia aino?o iiaaiiiith aac
oneeaaeiaiue (AI), 37 oai?eo ia iiaaiiiith, oneeaaeiaio aeano?oeoe??th
(AeI) (na?aae ieo 10 c aioo?ioiueieaaaiaaeie oi?iaie, 26 – ?c
eaaaiaai-ieaa?aeueiith oi?iith, 1 c? ci?oaiith oi?iith aeano?oeoei?), 24
oai?eo ia o?ii?/iee a?iio?o ? 29 – ia a?iioiaeoaoe/io oai?iao. Ca
a?o?aieie aeaieie aea/aii 80 inoi??e oai?iae: 61 – ae?oe ?c iiaaiiii?th
aac oneeaaeiaiue, 1 – ?c aeano?oeoeaiith iiaaiiii?th, 6 – c o?ii?/iei
a?iio?oii, 12 – ?c a?iioiaeoaoe/iith oai?iaith. Iaoe??ioe c o?ii?/iei
a?iio?oii ? a?iioiaeoaoe/iith oai?iaith ia i?aenoaa? noaoenoe/ii?
ia?iaee ?acoeueoao?a aeine?aeaeaiiy ? i?iaaaeaiiai ei?aeyoe?eiiai
aiae?co aoee ia’?aeiai? a a?oio OICE.

Ae?aaiic anoaiiaethaaany ca?aeii c eeaneo?eaoe??th ianiaoeeo?/ieo
a?iioieaaaiaaeo caoai?thaaiue o ae?oae, ui cai?iiiiiaaia ia II c’?cae?
ooiciao??a ? ioeueiiiieia?a Oe?a?ie (Ee?a, 1998).

Eaai?aoi?ia ianoaaeaiiy oai?eo i?iaiaeeeiny a aino?iio ia??iae? ? a
ia??iae? ee?i?/iiai iie?ioaiiy. Iaea?aeai? ?acoeueoaoe ii??aithaaeeny c
iieacieeaie caei?iaeo ae?oae e?einueei? iiioeyoei?.

I?e ae??ooaaii? iinoaaeaieo caaaeaiue a?aoiaoaaee a?e, noaoue, a?oie
e?ia? nenoaie AA0, Rhesus.

A?oie e?ia? nenoaie AA0, Rhesus aecia/aeeny noaiaea?oieie ne?iaaoeaie,
ui aeaioiaeaii E?einueeith INIE.

Iioiieia?/ii aeine?aeaeaiiy i?iaiaeeeeny a aeaio a?eiaeo eaoaai??yo:
a?ae 1 aei 6 ?ie?a ? a?ae 7 aei 14 ?ie?a. Iioa?aae i?ae aeine?aeaeaiiyi
a aino?iio ia??iae? ? a ia??iae? aeaeoaeaiiy neeaaeaa 3 oeaei?. Aeey
aecia/aiiy a?aeiinii? ? aaniethoii? e?eueeino? O-eiioioeeo?a oa ?o
noaiiioeyoe?e a e?ia?, o 59 ae?oae (36 oai?eo ia iiaaiiiith ? 23 oai?eo
ia OICE) aeei?enoiaoaaee iaoiae niiioaiiiai ?icaoeiooai?aiiy ?c
a?eo?ioeeoaie aa?aia (A-?oe), o 22 ae?oae (a a?oi? OICE, a?e 7-14 ?ie?a)
– iaoiae iiiieeiiaeueieo aioeo?e. Iaoiaeii A-?oe ii Jondal et al., 1972,
aecia/aee caaaeueio e?euee?noue O-e ? e?euee?noue O-oaioieii?acenoaioieo
(O-oo?, ui iathoue oaeia?io aeoeai?noue) oa O-oaioieii/ooeeaeo (O-oo/, c
noi?ani?iith aeoeai?noth ) eiioioeeo?a – ii A. Shore et al., 1978. A
?aaeoe?? iai?yii? iioiioethi?anoeaioei? (Remherz et al., 1979),
aeei?enoiaoth/e iiiieeiiaeuei? aioeeiioioeeoa?i? aioeo?ea na??? EEI
(EEI90, EEI86, EEI31), aecia/aee aeeoa?aioe?thaaeuei? aioeaaie iaia?aie
ia?eoa?e/ieo O-eiioioeeo?a: CD3 (O-caaaeuei? eiioioeeoe), CD4
(?aaoeyoi?ia noaiiioeyoe?y O-oaeia??a), CD8 (aoaeoi?i? O-eiioioeeoe), ?c
ianooiiei i?ae?aooaaiiyi ia ethiiianoeaioiiio i?e?ineii?.

Ai?no iioiiaeiaoeii?a A, M, G a ne?iaaooe? e?ia? aecia/aee iaoiaeii
?aaeiaeueii? iioiiaeeooci? a aaa?? ii G. Manchini et al., 1965, c
aeei?enoaiiyi aioene?iaaoie ? noaiaea?o?a Ieaeiueiai?iaenueeiai IAe?
aiiaeaiiieiai? oa i?e?iaiieiai?.

Aeey ioe?iee ?ie? i?ioean?a i?ioaieico ? N?I i?e aino??e oa o?ii?/i?e
iaoieiai? eaaaiue aeine?aeaeaii i?noeaaee noai iniiaieo eiiiiiaio?a oeeo
nenoai oeyoii aea/aiiy ai?noo a?iioiaeueaaiey?ieo nae?ao?a, ui a?eueo
niaoeeo?/ii a?aeia?aaeo? o/anoue oeeo nenoai a ?icaeaaii? iaoieiai?.
Ine?eueee caeaaeiino? aeaieo iieaciee?a a?ae a?eo aeyaeaii ia aoei, aiie
aiae?coaaeeny a iaei?e a?eia?e eaoaai??? a?ae 1 aei 14 ?ie?a.
A?iio?aeuei? cieae iaae?aeeny i?ae /an i?yii? a?iioineiii?, ui
i?iaiaeeeany i?ae aa?aioo?aoiei ia?eicii 53 ae?oyi ?c OICE a ia??iae?
caaino?aiiy, 6 ae?oyi ?c iiaaiiii?th aac oneeaaeiaiue oa 28 ae?oyi,
oai?ei ia aeano?oeoeaio iiaaiiiith a aino?iio ia??iae?.

Eiiiiiaioe IAN aeine?aeaeoaaee ca ?icuaieaiiyi neioaoe/ieo noano?ao?a:
aeanoaciiiae?aio aeoeai?noue (AIA) – ca a?ae?ie?cii
N-o-aie-aeaiie-i-iio?ioaiieiaiai ao??o (Iaeiaeiia I.A., 1980),
aioeo?iioe/io aeoeai?noue (AOA) ? -2-IA – i?e?iiaoiaeii ?onaeiaa N.A. ?
Eoaeoeiia A.A., 1995.

C eiiiiiaio?a IAI-nenoaie aeine?aeaeoaaee ia?aeii? i?iaeoeoe IIE –
aei?iia? eii’thaaoe (AeE), oeyoii ?o aeno?aeoei? noi?ooth
aaioai-icii?iiaiie (Aaa?ieia A.A., Iaoei?oaeia I.?., 1983), aoi?eii?
i?iaeoeoe IIE – i?iaeoeoe, ui aeoeai? aei oiiaa?aioo?iai? eeneioe
(OAEAI), ca eieuei?iaith ?aaeoe??th ?c 2-OAE a i?enooiino? iii?a Fe (3+)
(Asakawa T., Matsushita S., 1980). ?acoeueoaoe ae?aaeaee a iaeeieoeyo
iioe/ii? u?eueiino? (A) ia 1 ia eiiiae?a. Eiiiaee aecia/aee
oinoi?ii-aai?e?iiaei iaoiaeii. Aecia/aiiy aioeieenethaaeueiiai
iioaioe?aeo AAN aeeth/aei aeine?aeaeaiiy oea?oeiieaciiio iiaeeo?eiaaiei
iaoiaeii ?aaiia.

Noaoenoe/ia ia?iaea i?iaiaeeeany c aeei?enoaiiyi O-e?eoa??th
No’thaeaioa, ?aa?anieiiai oa ei?aeyoe?eiiai aiae?co ia IBM PC.

?acoeueoaoe aeine?aeaeaiue oa ?o iai??eoaaiiy

I?iaaaeaia aeine?aeaeaiiy aeicaieeei aeyaeoe ca’ycie i?ae
?acenoaioi?noth aeeoy/iai i?aai?cio, caeaoi?noth oi?ioaaiiy aeeoeiith
caoenieo ?aaeoe?e ? eiai oaiioeiiaeie iniaeeainoyie. I?inoaaeaia
caeaaei?noue ci?i a nenoaiao, ui aeine?aeaeoaaeenue, o ae?oae ?c
aino?ith oa o?ii?/iith iaoieiai?th eaaai?a a?ae a?eo, noao?, a?oi e?ia?.
?iciiae?e ianoaaeaieo ae?oae ca a?eii iaaaaeaii ia ?en.1.

Na?aae iaoe??io?a, oai?eo ia iaoneeaaeiaio iiaaiiiith, e?euee?nii
ia?aaaaeaee oeii/eee, ni?aa?aeiioaiiy ca noaooth (oeii/eee/ae?a/aoee)
neeaei 1,3. Iaea?eueo aenieei oeae iieaciee aoa o a?oe? 1-3 ?ie?a, ?
neeaa 2,4 (p0,05; -2-IA (ieI/a): ae?a/eiee 0,300,06, oeii/eee 0,450,04,
p

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