AeI?I?IIAO?IANUeEA AeA?AEAAIA IAAeE*IA AEAAeAI?ss

EACIss NA?A?E NOAI?NEAAIAE*

OAeE: 616.33+616.342/-002.44-085-037-072.1

AIAeINEII?*IA IAAeEEAIAIOICIA AEIEAAeA AEOEATH*EO IA?A?A OA E??IOA?AI?ss
A E?EOAAII? AeIAAI IACAAITHAAIEO AE?ACIE AeAAIAAeOessOEIAEI? EEOEE

14.01.03. – O??O?A?ss

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Aei?i?iiao?ianuee – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia o Caii??cueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee: eaiaeeaeao iaaee/ieo iaoe, aeioeaio A?ooea A.A.,
caa?aeoaa/ eo?no aiaeineii?? eaoaae?e aini?oaeueii? o??o?a??
Caii??cueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Io?oe?ei? iiiiaioe:

Aeieoi? iaaee/ieo iaoe, i?ioani? Aa?acieoeueeee sse?a Nieiiiiiae/,
caa?aeoaa/ eaoaae?e oaeoeueoaonueei? o??o?a?? ? o??o?a?? ?ioa?i?a
Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeai??.

Aeieoi? iaaee/ieo iaoe, i?ioani? Ne?ao ?aai Oaaei?iae/, caa?aeoaa/
eaoaae?e caaaeueii? o??o?a?? Caii??cueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

I?ia?aeia onoaiiaa – ?inoeooo ee?i?/ii? oa aenia?eiaioaeueii? o??o?a??
AII Oe?a?ie, eaoaae?a oi?aei-aaaeii?iaeueii? oa noaeeiii? o??o?a??, i.
Ee?a.

Caoeno a?aeaoaeaoueny » 25 “ o?aaiy 1999 ?. i 11-00 aiaeei? a
aoaeeoi??? 9 ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 08.601.01 a
Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai?? IIC Oe?a?ie (320044,
Aei?i?iiao?ianuee, aoe. Aeca?aeeinueeiai, 9).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai?? (320044, Aei?i?iiao?ianuee, aoe.
Aeca?aeeinueeiai, 9).

Aaoi?aoa?ao ?ic?neaiee “ 21 “ ea?oiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe, aeioeaio
Oea/aiei A.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Ae?aceiaa oai?iaa oeoiea (AOO) oa
aeaaiaaeoeyoeiaei? eeoee (AO AeIE) caeeoa?oueny aeooaeueiith i?iaeaiith
aano?iaioa?ieia?? oa o??o?a?? (Aaneeaiei A.O., A?aaaiueia I.E., 1981;
A?eai?ue?a I.ss., 1986, 1995). Iniaeea? o?oaeiiu? a e?eoaaii?
i?aaenoaaeythoue oai?? c aeiaai iacaaithaaieie ae?aceaie (AeIA). O oeeo
oai?eo iaa?oue ianeaia i?ioeae?aceiaa oa?ai?y c canoinoaaiiyi
I2–aeieaoi??a aai ?ia?a?oi??a i?ioiiii? iiiie oa aioeaaeoa??aeueieo
i?aia?ao?a ia i?ecaiaeeoue aei caaithaaiiy ae?acie ? aeieea? ieoaiiy i?i
?o iia?aoeaia e?eoaaiiy. Oiio iio??aia iiaeaeueoa ?ic?iaea iaiia?aoeaieo
iaoiae?a e?eoaaiiy oai?eo c AeIA AeIE (Eeeiia I.I., 1990; Iaei?ia A.I.
oa ni?aaao., 1989, 1992). A inoaii? ?iee oe?iea aeei?enoaiiy ciaoiaeyoue
??ciiiai?oi? iaoiaee aiaeineii?/ii? oa?ai?? AO. Iaea?eueo /anoi a
oaia??oi?e /an aeei?enoiao?oueny eaca?ioa?ai?y (EO) oa i?noeaaa
aie?eaoe?y ia ae?aceo e?ea?nueeeo i?aia?ao?a (Aiae??aiiaa I.I. oa
ni?aaao., 1991; Aaeaaeia ?.I. oa ni?aaao., 1988; Aooeo A.I., oa
ni?aaao., 1984; Eiiae?aoia A.A., 1982; ?e/aaia A.I. oa ni?aaao.,1993;
Nieiiao?i A.Ae. oa ni?aaao., 1991; Oea?ueia I.?. oa ni?aaao., 1986,
1989). Ia?niaeoeaieie yaeythoueny iaoiaee aiaeineii?/ii? aeaia?aaoe??
oeoiea oa e??iaieea ia ae?aceo. Iaei/enaeuei? ?iaioe, i?enay/ai? oeei
iaoiaeai, na?ae/aoue i?i ?o aenieo aoaeoeai?noue. Aea o an?o aeiaaeeao,
ye aiaeineii?/ia iaaeeeaiaioicia aeieaaea aeoeath/eo ia?a?a (AIAAI) oae
? e??ioa?ai?y (EO) canoiniaoaaeeny ie?aii iaeei a?ae iaeiiai, ui
aeicaieyei aieeaaoe aai o?eueee ia eeneioii?iaeoeoe?eio ooieoe?th oeoiea
(EIO), aai o?eueee ia caaithaaiiy ae?acee. A?aoiaoth/e aaaeeea?noue
ii?iae?caoe?? iniiaieo ooieoe?e oeoiea, e?ea?aeaoe?? iaoieia?/ii?
i?e?ioei?e (Helicobacter pylori) (HP), ni?eyth/eo caaithaaiith ae?acee,
a oaeiae oie oaeo, ui noi?nii AIAAI oa EO ii aeaiei e?oa?aoo?e ia
canoiniaoaaeeny, oiio aeey ioe?iee ?o aoaeoeaiino? iaiao?aeii aoei
aea/eoe aieea canoiniaaiiai iaie iaoiaeo ia oe? i?ioeane. Cai?iiiiiaaia
iaie iaoiaeeea noi?nii? AIAAI oa EO aeei?enoiao?oueny aia?oa oa
aeicaiey? eiiieaenii aieeaaoe ye ia eeneioii?iaeoeoe?th, oae ? ia no?iee
caaithaaiiy ae?acee, ui i?aeaeuo? aoaeoeai?noue e?eoaaiiy oai?eo c AeIss
AeIE.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie. Oaia aeena?oaoe?eii? ?iaioe
ca’ycaia c iniiaiei iai?yieii iaoeiaeo aeine?aeaeaiue eaoaae?e
aini?oaeueii? o??o?a?? Caii??cueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo: “Iaoiaee e?eoaaiiy ae?aceiai? oai?iae oeoiea oa
aeaaiaaeoeyoeiaei? eeoee”, oeo? i?iaeaie 01.850012.016.

Iaoa ? caaea/? aeine?aeaeaiiy. Iie?ioeoe ?acoeueoaoe e?eoaaiiy AeIA
AeIE, aia?oa aeei?enoaaoe iaoiaeeeo noi?nii? AIAAI oa EO oa aea/eaoe ??
aieea ia iniiai? ooieoe?? oeoiea, ii?oieia?/i? ? ?aaaia?aoi?i?
ii?ooaiiy, canaeai?noue aio?aeueiiai a?aeae?eo oeoiea (AAO) H?, ui
ni?eyoeia a o?e /e ?io?e i??? ii?iae?caoe?? oeeo ooieoe?e, a oaeiae
aeicaieeoue nei?ioeoe no?iee oa i?aeaeueoe a?aenioie caaithaaiiy oeeo
ae?acie.

A?aeiia?aeii aei iaoe, iaiao?aeii aoei ae??oeoe ne?aeoth/? caaaeaiiy:

1. Aea/eoe ii?oieia?/i? oa ?aaaia?aoi?i? ci?ie neeciai? iaieiiee oeoiea
(NIO) i?e AeIA AeIE oa ?o noai i?e aeei?enoaii? AIAAI oa EO.

2. Aea/eoe aieea noi?nii? AIAAI oa EO ia i?e?ioei?o oeoiea.

3. Aea/eoe aieea noi?nii? AIAAI oa EO ia eeneioii?iaeoeoe?eio ooieoe?th
oeoiea.

4. Aea/eoe aieea noi?nii? AIAAI oa EO ia iioi?ii-aaaeoaoi?io ooieoe?th
oeoiea (IAO).

5. Aea/eoe aieea noi?nii? AIAAI oa EO ia no?iee caaithaaiiy AeIA AeIE.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Caeiaoaa/ai aia?oa aea/aii
aieea noi?nii? AIAAI oa EO ia ii?oieia?/i? oa ?aaaia?aoi?i? ci?ie NIO,
I?, EIO oa IAO oeoiea, no?iee caaithaaiiy ae?acee. Canoinoaaiiy noi?nii?
AIAAI oa EO aeicaiey? ciaioeoe e?euee?noue oa nooi?iue ii?ooaiue
?aaaia?aoi?ieo ci?i, e?ea?aeoaaoe aeoeai?noue caiaeueiiai i?ioeano a NIO
oa ?cieueiaai? aeenieac?? I-II nooiaiy. Aeei?enoaiiy cai?iiiiiaaii?
iaoiaeeee oaeiae ni?ey? cieaeaiith eeneioiooai?aiiy, ii?iae?co?
iioi?ii-aaaeoaoi?i? ii?ooaiiy oa ciaioo? canaeai?noue AAO H?, ui a naith
/a?ao aeicaiey? nei?ioeoe no?iee oa ca?eueoo? a?aenioie ?oaoethaaiiy
AeIA AeIE. Iaaoaeoeai?noue AIAAI oa EO, i?iaaaeaieo ia?aeaeueii c
aaceniith i?ioeae?aceiaith oa?ai??th c aeei?enoaiiyi aioeaaeoa??aeueieo
i?aia?ao?a, neoaeeoue ia’?eoeaiei e?eoa???i iaiao?aeiino? iia?aoeaiiai
ao?o/aiiy.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Cai?iiiiiaaia noi?nia AIAAI
oa EO aeicaiey? ii?iae?coaaoe iniiai? ooieoe?? oeoiea, ciaioeoe
e?euee?noue oa nooi?iue ii?ooaiue ii?oieia?/ieo oa ?aaaia?aoi?ieo ci?i,
a oaeiae canaeai?noue AAO I?, e?ea?aeoaaoe aeoeai?noue caiaeueiiai
i?ioeano a NIO oa ?cieueiaai? aeenieac?? I-II nooiaiy, ui a naith /a?ao
aeicaiey? nei?ioeoe no?iee oa ca?eueoo? a?aenioie ?oaoethaaiiy AeIA
AeIE. Iaaoaeoeai?noue AIAAI oa EO, i?iaaaeaii? ia?aeaeueii c aaceniith
i?ioeae?aceiaith oa?ai??th c aeei?enoaiiyi aioeaaeoa??aeueieo
i?aia?ao?a, neoaeeoue ia’?eoeaiei e?eoa???i iaiao?aeiino? iia?aoeaiiai
ao?o/aiiy. Cai?iiiiiaaiee iaoiae noi?nii? AIAAI oa EO ai?iaaaeaeaii a
aiaeineii?/iiio a?aeae?eaii? Caii??cueei? iaeanii? ee?i?/ii? e?ea?i?
(aeo ai?iaaaeaeaiiy a?ae 16 eenoiiaaea 1998 ?.), iaaeeei-nai?oa?i?e
/anoei? ?7 caaiae?a “Caii??aenoaeue” oa “Aei?i?iniaoenoaeue” i.
Caii??aeaey (aeo ai?iaaaeaeaiiy a?ae 20 eenoiiaaea 1998 ?.), i?nueei?
e?ea?i? ?1 i. Iae?oiiiey (aeo ai?iaaaeaeaiiy a?ae 10 a?oaeiy 1998 ?.),
aiaeineii?/iiio eaa?iao? Eoeaeoaanueei? Oe?E (aeo ai?iaaaeaeaiiy a?ae 01
a?oaeiy 1998 ?.). Iaoa??aee aeena?oaoe?? aeeth/aii a eo?n iaa/aiiy aeey
nooaeaio?a Caii??cueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?y ? iniaenoith i?aoeath aaoi?a,
yeee i?ia?a aiae?c iaoeiai? e?oa?aoo?e ca oaiith ?iaioe, aeeiiaa
aeeaieee ?ioi?iaoe?eiee iiooe, i?ia?a aiae?c ee?i?/iiai iaoa??aeo. An?
aiaeineii?/i? aeine?aeaeaiiy c acyooyi ii?oieia?/iiai iaoa??aeo,
aeine?aeaeaiiy IAO oeoiea ca aeiiiiiaith aeeiai?/ii? aano?inoeeio?a?ao??
oa OC–aeine?aeaeaiiy, AIAAI oa EO, noaoenoe/ia ia?iaea iaoa??aeo
aeeiiaia iniaenoi caeiaoaa/ai. Aeni?an-ae?aaiinoeea I? oa aeine?aeaeaiiy
EIO oeoiea, a?noieia?/i? oa ii?oieia?/i? aeine?aeaeaiiy i?iaaaeai?
noi?nii c ni?a?ia?oieeaie eaoaae?e aini?oaeueii? o??o?a??
Caii??cueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (caa?aeoaa/ –
ae.i.i., i?ioani? I?eiiaiei I.N.), iaoieiai — aiaoii?/iiai a?aeae?eaiiy
Caii??cueei? iaeanii? ee?i?/ii? e?ea?i? (caa?aeoaa/ – Caoaethe A.I.) oa
eaoaae?e eaai?aoi?ii? ae?aaiinoeee Caii??cueeiai ?inoeoooo
oaeineiiaeaiiy e?ea??a (e.i.i., aeioeaio E?eaioaonueea TH.I.). A noi?nii
iioae?eiaaieo ?iaioao aaoi?o iaeaaeeoue a?ae 25% aei 75% ?aeae oa
?ic?iaie.

Ai?iaaoe?y ?iaioe. ?acoeueoaoe ?iaioe aeiiia?aeaeenue oa
iaaiai?thaaeenue ia: 1) VI ?anioae?eainuee?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Canoinoaaiiy eaca??a o iaaeeoeei? oa a?ieia??” (Oa?e?a,
1996 ?.); 2) iaoeiai-i?aeoe/i?e eiioa?aioe?? aiaeineii?no?a Oe?a?ie
“Aeooaeuei? i?iaeaie ae?aaiinoe/ii? oa e?eoaaeueii? aiaeineii??” (Ee?a,
1996 ?.), ia i?aeeaoaae?aeueiiio can?aeaii? eaoaae? aini?oaeueii?,
caaaeueii? oa oaeoeueoaonueei? o??o?a??, a oaeiae eaoaae?e aioo??oi?o
oai?ia CAeIO, eaoaae?e o??o?a?? C?OE, 57-e iaoeia?e eiioa?aioe??
iieiaeeo a/aieo CAeIO oa C?OE (1996?.); can?aeaii? Caii??cueeiai
iaeaniiai o??o?a?/iiai iaoeiaiai oiaa?enoaa (1995 – 1997 ??.), ia
oaoiaiio nai?ia?? c oo?o?a?? o niaoe?aae? Ae 08.601.01 o
Aei?i?iiao?ianuee?e aea?aeaai?e iaaee/i?e aeaaeai??.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 13 iaoeiaeo ?ia?o:
c ieo 6 noaoae o oaoiaeo iaaee/ieo aeo?iaeao, 7 – o aeaeyae? oac a
ca??ieeao i?aoeue c’?cae?a oa eiioa?aioe?e.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny c anooio,
iaeyaeo e?oa?aoo?e, iieno iaoiaeee aeine?aeaeaiiy oa oa?aeoa?enoeee
ee?i?/ieo niinoa?aaeaiue, aeaio ?icae?e?a aeanieo aeine?aeaeaiue,
aiae?co oa ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae. Aeena?oaoe?y
aeeeaaeaia ia 144 noi??ieao iaoeiiieno. Oaeno ?ethno?othoue 21 oaaeeoey
oa 6 iaethie?a, ye? caeiathoue 20 noi??iie. Nienie aeei?enoaieo aeaea?ae
i?noeoue iineeaiiy ia 244 i?aoe?, c ieo 184 ?iaioe a?o/eciyieo oa 60
caei?aeiiieo aaoi??a.

INIIAIA *ANOEIA.

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. ?iaioa aaco?oueny ia ?acoeueoaoao
e?eoaaiiy 141 oai?iai c AO AeIE a oiiaao aiaeineii?/iiai a?aeae?eaiiy
Caii??cueei? iaeanii? ee?i?/ii? e?ea?i? c 1993 ii 1996 ?iee. Iniiaio
a?oio neeaee 78 oai?eo c AeIA AeIE, eiio?ieueio a?oio ?1 – 30 oai?eo c
AeIA AeIE, io?eioaaaoeo ?cieueiaaio EO, eiio?ieueio a?oio ?2 – 33 oai?eo
c ae?aceaie AeIE, io?eioaaaoeo aacenio i?ioeae?aceiao oa?ai?th.
Iieacaiiyi aei i?iaaaeaiiy AIAAI oa EO aoea iayai?noue o oai?eo AeIA
AeIE (ae?acee, ia caaeeaath/? ia i?ioyc? 2-o ? a?eueoa i?nyoe?a,
?aoeeaeeaoth/? a?eueoa 2-o ?ac?a ia ??e aai ae?acee c iino?eii
?aoeeaeeaoth/ith oa/??th). Iaoe??ioe ye iniiaii?, oae ? eiio?ieueieo
a?oi i?ae /an i?iaaaeaiiy AIAAI oa EO iaea?aeoaaee i?ioeae?aceiao
oa?ai?th, aeeth/ath/o I2–aeieaoi?e aai ?ia?a?oi?e i?ioiiii? iiiie oa
aioeaaeoa??aeuei? i?aia?aoe. An?i oai?ei i?iaiaeeee aiaeineii?th c
i?eoe?eueiith a?iin??th, aea/aiiy EIO, IAO oa i?e?ioei?e oeoiea (I?), a
oaeiae ii?oieia?/ieo ci?i NIO oa AeIE. A?e ianoaaeaieo iaoe??io?a
eieeaaany a?ae 23 aei 70 ?ie?a. Oeoieiaa eeneioiooai?aiiy aea/aii
aeaeo?iiao?e/iei iaoiaeii o aacaeueiiio ia??iae? nae?aoe?? ca
aeiiiiiaith ?I-i?e?iciiae?a IA-?I-2 ae?iaieoeoaa NEA IAO (i.
Eai’yiaoeue-Iiae?euenueeee) oa ?iaeeeaoi?o eeneioiino? oeoieiaiai nieo
(?EO-2). IAO oeoiea aea/aeany iaoiaeii aeeiai?/ii? aano?inoeeio?a?ao??
(AeANA) ia eiii’thoa?ii-noeeio?a?ao?/i?e nenoai? “Aaiia” (Oai?ueia) oa
ca aeiiiiiaith OC-aia?aoo “Sonoline S1” o??ie “Siemens”. Aeey aeyaeaiiy
I? i?ae /an o?a?iaano?ineii?? a?aee ii 2 a?iioaoe neeciai? iaieiiee c
e?ath ae?acee, AAO oa o?ea oeoiea (OO) aeey i?iaaaeaiiy eiiieaenii?
ae?aaiinoeee, yea aeeth/aea a?noieia?/iee iaoiae, a oaeiae
aeni?an-ae?aaiinoeeo: aea/aiiy o?aacii? aeoeaiino?, i?e?ineii?th
iace?a-a?aeaeoe?a, iioa?aiaaieo ca A?aiii. Ianoaaeaiiy oai?eo
i?iaiaeeee aei oa i?ney e?eoaaiiy, /a?ac 1-3, 6 i?nyoe?a, ??e oa 3
?iee i?ney e?eoaaiiy. Ii?aoethaaiiy iaea?aeaieo ?acoeueoao?a aaeiny ca
iaoiaeii aa??aoe?eii? noaoenoeee c aaeeaaiiyi e?eoa???a No’thaeaioa oa
eiao?oe??ioa caiaee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- I??niia
(En?-eaaae?ao).

?acoeueoaoe aeanieo aeine?aeaeaiiue. Aiaeineii?/ia ea?oeia i?e AeIA AeIE
aoea ??ciiiai?oiith ? caeaaeaea a?ae noaae?? ?icaeoeo, /anoioe
iiia?aaei?o caaino?aiue, eieae?caoe??. AeIA AeIE o cai?ioiiio ?icaeoeo
i?ioiaeeee ne?aeoth/? noaae??: aeoeaio, noaae?th noeoaiiy caiaeueieo
yaeu, noaae?th ?oaoethaaiiy oa noaae?th ?oaoey. E?eoaaiiy c
aeei?enoaiiyi AIAAI oa EO o oai?eo AO, ye i?aaeei, ii/eiaeinue a
aeoeai?e noaae??. Oae e?euee?noue oai?eo a aeoeai?e noaae?? ia?aa?ao
caoai?thaaiiy a iniiai?e a?oi? aoea 57 (73,1%) oa 20 oai?eo a
eiio?ieuei?e a?oi? ?1 (66,7%). A ca’yceo c? ciaioaiiyi iaa?yeo
neeciai? iaieiiee noai?thaaeinue a?aaeaiiy “iiaeeaeaiiy” ae?acee.
sse i?aaeei, o oe??? a?oie oai?eo a?aei?/aeinue aeayea iineeaiiy
aieueiaiai neiae?iio i?ney ia?oiai naaino. A aeoeai?e oac? iaaeiei
ae?aceiaiai aeaoaeoo o /anoeie oai?eo aoee iiaa?oiaa? a?ic??, ?ici??e
yeeo eieeaaeenue a?ae 0,3 aei 0,5 ni a ae?aiao??. A?iceai? ci?ie
a?aecia/ai? a 25 oai?eo: a iniiai?e a?oi? – o 19 iaoe??io?a (33,3%) oa o
6 oai?eo eiio?ieueii? a?oie ?1 (30,0%). Ca?eueoaiiy ?ici???a ae?aceiaiai
aeaoaeoo a ?acoeueoao? ciaioaiiy ia?eoa??eiiai iaa?yeo neeciai?
iaieiiee, a oaeiae ca ?aooiie i/euaiiy e?a?a ae?acee oa ?? aeia,
na?ae/eei i?i ianoaiiy ae?oai? noaae?? ia?aa?ao ae?aceiai? oai?iae –
noaae?? noeoaiiy caiaeueieo yaeu. Oey noaae?y ia ii/aoeo e?eoaaiiy aoea
a?aei?/aia o 21 iaoe??ioa iniiaii? a?oie (26,9%) oa o 10 oai?eo
eiio?ieueii? a?oie ?1 (33,3%). Ee?i?/ii ia oe?e noaae?? ia?aa?ao AO
a?aei?/aii e?ea?aeoaaiiy aieueiaiai neiae?iio o 73,9% oai?eo oa
ciaioaiiy aai iiaia cieeiaiiy aeeniaine/ieo ii?ooaiue. O?aoy noaae?y –
noaae?y ?oaoethaaiiy – oa?aeoa?eco?oueny ciaioaiiyi ae?acee ye a
?acoeueoao? ciaioaiiy iaa?yeo, oae ? ?icaeoeo a?aioeyoe?eii? oeaieie ia
?? aei?. *aoaa?oa noaae?y – noaae?y ?oaoey – ae?eyiea ia i?noe?
eieeoiuei? ae?acee, cae/aeii yne?aai-/a?aiiiai eieuei?o, c
eiiaa?aaioe??th neeaaeie oa ciiith a?ia?ai?? iaaeiei (noaae?y /a?aiiiai
?oaoey). ?oaaoeue iiaea aooe e?i?eii?, ??aeoa c??eiiiae?aii? oi?ie, ia
aeeeeeath/ee a?oai? aeaoi?iaoe?? i?aaio oa i?eaeaath/ee /a?ac 2-3
i?nyoe? a?eoaaoee eie?? (noaae?y a?eiai ?oaoey). Oey noaae?y aoea
a?aei?/aia o 55 oai?eo iniiaii? a?oie (70,5%) oa o 16 oai?eo
eiio?ieueii? a?oie ?1 (53,3%). Aiaeineii?/ia aeine?aeaeaiiy oai?eo AO ia
iaiaaeoaaeiny aeyaeaiiyi ae?aceiaiai aeaoaeoo neeciai? iaieiiee, a
aeeth/aei oaeiae ioe?ieo noaio NIO oa AeIE. Oiiaii aeae?eeee 3 nooiaiy
aeoeaiino? caiaeaiiy NIO oa AeIE.

Aeoeai?noue I nooiaiy (iii??ii ae?aaeaia caiaeaiiy) oa?aeoa?eco?oueny
ia??aiii??iei iaa?yeii neeciai? iaieiiee c ae?eyieaie a?ia?ai?? o
aeaeyae? ieyi (“ieyienoa a?ia?ai?y”) c iayai?noth neeco. Iaea?eueo /anoi
caiaeuei? ci?ie I nooiaiy aeoeaiino? a neecia?e iaieiioe? AAO
niinoa??aaeenue o oai?eo eiio?ieueii? a?oie ?2 — 60,6% aeiaaee?a, iaio
/anoi oaea aeoeai?noue caiaeaiiy aoea a eiio?ieuei?e a?oi? ?1 — 33,3% ?
ua ??aeoa a iniiai?e a?oi? oai?eo — 29,5% aeiaaee?a (?<0,05). Caiaeuei? ci?ie I nooiaiy a neecia?e iaieiioe? AeIE /ano?oa ae?aaiinooaaeenue o oai?eo eiio?ieueii? a?oie ?2 - 51,5% aeiaaee?a, ??aeoa a eiio?ieuei?e a?oi? ?1 – 16,7% aeiaaee?a ? ua ??aeoa a iniiai?e a?oi? oai?eo - 14,1% aeiaaee?a (p<0,05). I?e aeoeaiino? II nooiaiy (ae?aaeaia caiaeaiiy) a neecia?e iaieiioe? – aeeoociee iaa?ye, ??cea a?ia?ai?y, c ae?eyieaie i?aeneeciaeo e?iaiaeeea?a, aiia eaaei ?aieia, i?noeyie ae?eoa a?eoaaoei neecii. Aeua ia?ae?/ai? ci?ie neeciai? iaieiiee AAO /ano?oa anueiai cono??/aeenue o oai?eo iniiaii? a?oie - 43,6% aeiaaee?a, iaio /anoi a eiio?ieuei?e a?oi? ?1 - 40,0% ? ua ??aeoa a eiio?ieuei?e a?oi? ?2 - 24,2% aeiaaee?a (p<0,05). Caiaeuei? ci?ie II nooiaiy aeoeaiino? a neecia?e iaieiioe? AeIE o an?o o?ueio a?oiao oai?eo cono??/aeenue iaeaea c iaeeiaeiaith /anoioith (p>0,05).

I?e aeoeaiino? III nooiaiy (??cei ae?aaeaia caiaeaiiy) ii?yae c? cia/iei
aeeoociei iaa?yeii oa a?ia?ai??th neeciai? iaieiiee, i?aeneeciaeie
aaii?aa?yie ia ?? iiaa?oi? aecia/aeenue i?noeaa? aeaoaeoe (a?ic??),
ia??aeei aaaaoi/enaeuei?, ceeaath/enue a iiey. Oae? ci?ie a neecia?e
iaieiioe? AAO ??aeoa anueiai cono??/aeenue a eiio?ieuei?e a?oi? ?2 —
15,2% aeiaaee?a, a?eueo /ano?oa a iniiai?e — 19,2% oa ua /ano?oa o
oai?eo eiio?ieueii? a?oie ?1 — 26,7% aeiaaee?a (p>0,05). Aeoiaeai?oe III
nooiaiy aeoeaiino? c iacia/iith ??cieoeath a /anoio? /ano?oa
ae?aaiinooaaeenue a eiio?ieuei?e a?oi? ?1 — 53,3% ? iniiai?e — 50,0%
aeiaaee?a, ??aeoa anueiai o oai?eo eiio?ieueii? a?oie ?2 — 21,2%
aeiaaee?a (p<0,05). A ca'yceo c oei, ui ii aeaiei aiaeineii?/iiai aeine?aeaeaiiy a?ae??cieoe ii?oieia?/i? oi?ie aano?eoo oa aeoiaeai?oo iaiiaeeeai, ie i?iaaee aiae?c ?acoeueoao?a a?noieia?/iiai aeine?aeaeaiiy neeciai? iaieiiee ??cieo a?aeae?e?a oeoiea oa AeIE. Iiaa?oiaaee aano?eo ii aeaiei a?noieia?/iiai aeine?aeaeaiiy iaea?eueo /anoi cono??/aany o oai?eo eiio?ieueii? a?oie ?2 - 36,4% aeiaaee?a, aeae?eueea ??aeoa a iniiai?e a?oi? - 20,5% ? ua ??aeoa o oai?eo eiio?ieueii? a?oie ?1 - 16,7% aeiaaee?a (p<0,05). ?ioa?noeoe?aeueiee aano?eo ye a iniiai?e a?oi? oai?eo - 10,8% aeiaaee?a, oae ? a eiio?ieueieo a?oiao ?1 - 10,0% oa ?2 - 15,2% aeiaaee?a, cono??/aany c iacia/iith ??cieoeath ii /anoio? (p>0,05). O?ii?/iee ao?io?/iee aano?eo aac ia?aaoaeiae caeic iaea?eueo
/anoi ae?aaiinooaaany o oai?eo iniiaii? a?oie — 35,9% aeiaaee?a,
aeae?eueea ??aeoa a eiio?ieuei?e a?oi? ?1 — 33,3% oa ua ??aeoa o oai?eo
eiio?ieueii? a?oie ?2 — 12,1% aeiaaee?a (p<0,05). Ao?io?/i? i?ioeane oa eeoeiaa iaoaieac?y /ano?oa anueiai ae?aaiinooaaeenue o oai?eo eiio?ieueii? a?oie ?1 - 30,0% aeiaaee?a, ??aeoa a iniiai?e - 25,6% oa ua ??aeoa o oai?eo eiio?ieueii? a?oie ?2 - 18,2% aeiaaee?a (p>0,05). A ?yae? aeiaaee?a ao?io?/i? i?ioeane a NIO noi?iaiaeaeoaaeenue
a?ia?ieanoe/ieie i?ioeanaie (ao?io?/iee a?ia?ieanoe/iee aano?eo), ??aeoa
anueiai cono??/ath/eeny o oai?eo iniiaii? a?oie — 7,7% aeiaaee?a,
aeae?eueea /ano?oa a eiio?ieuei?e a?oi? ?1 — 10,0% oa ua /ano?oa o
oai?eo eiio?ieueii? a?oie ?2 – 18,2% aeiaaee?a (p>0,05). I?e
aeine?aeaeaii? a?iioao?a neeciai? iaieiiee a?aei?/aeenue ??ciiiai?oi?
oi?ie aeoiaeai?oo – a?ae iiaa?oiaaiai aei ao?io?/iiai. Iaea?eueo aeniea
/anoioa ae?aaiinoeee iiaa?oiaaiai aeoiaeai?oo a?aei?/aia o oai?eo
eiio?ieueii? a?oie ?2 – 54,5% aeiaaee?a, aeae?eueea ??aeoa o oai?eo
eiio?ieueii? a?oie ?1 — 33,3% oa ua ??aeoa a iniiai?e a?oi? oai?eo —
24,4% aeiaaee?a (p<0,05). ?ioa?noeoe?aeueiee aeoiaeai?o ??aeoa anueiai cono??/aany o oai?eo eiio?ieueii? a?oie ?2 - 24,2% aeiaaee?a, a?eueo /ano?oa a eiio?ieuei?e a?oi? ?1 - 26,7% oa cia/ii /ano?oa o oai?eo iniiaii? a?oie – 41,0% aeiaaee?a (p<0,05). Iaea?eueo aeniea /anoioa aeyaeaiiy ao?io?/iiai aeoiaeai?oo o oai?eo AeIss AeIE niinoa??aaeanue a eiio?ieuei?e a?oi? ?1 - 40,0% aeiaaee?a. Aeae?eueea ??aeoa ao?io?/iee aeoiaeai?o aoa ae?aaiinoiaaiee a iniiai?e a?oi? – 34,6%, oa ua ??aeoa o oai?eo eiio?ieueii? a?oie ?2 – 21,2% aeiaaee?a (p<0,05). Oaeei /eiii, o oai?eo c AeIss AeIE ye a iniiai?e, oae ? a eiio?ieuei?e a?oi? ?1 ia?aaaaeaee a?eueo aeeaie? ii?oieia?/i? ci?ie neeciai? iaieiiee, ye? oa?aeoa?ecothoueny i?iieeiaiiyi caiaeueii-aeeno?io?/ieo i?ioean?a ia anth oiauo NIO oa AeIE, iacai?ioi?noth ii?oieia?/ieo ci?i, e?iai- oa e?ioinoaco, iineeaiiith ee?oeiaith ?io?eueo?aoe??th, ??ciiiai?oieie ?aaaia?aoi?ieie ii?ooaiiyie. Nooo?aeo a?aei?iiinoae a ii?oieia?/ieo ci?iao neeciai? iaieiiee AAO i?ae iniiaiith ? eiio?ieueiith a?oiith ?1 ia a?aecia/aii. O a?eueoino? oai?eo c AeIA AeIE (79,6%) iaeenue ??ciiiai?oi? ii?ooaiiy ?aaaia?aoi?ieo i?ioean?a (N??ia A.A. oa ni?aaao., 1985, O?oa? E.E. oa ni?aaao., 1990, Oiiae?aeca A.A., 1982, Carrik J. et al., 1989). A caeaaeiino? a?ae nooiaiy ?aaaia?aoi?ieo ii?ooaiue aeae?eeee ne?aeoth/? a?oie oai?eo (Aooia TH.E., 1987, Aaneeaiei A.O. oa ni?aaao., 1989, Iao?ia A.I. oa ni?aaao.,1994, Nagayo T., 1977,1981): I. O?ii?/iee aano?eo aac ii?ooaiiy ?aaaia?aoi?ieo i?ioean?a. II. O?ii?/iee aano?eo c ii?ooaiiyie ?aaaia?aoi?ieo i?ioean?a: a) c ia??cei ae?aceeaeie yaeuaie i?ie?oa?aoe??, ia?aaoaeiae caeic, eeoeiai? iaoaieac??. a) c ae?aceeaeie yaeuaie i?ie?oa?aoe??, ia?aaoaeiae caeic, eeoeiai? iaoaieac??. III. O?ii?/iee aano?eo c aeenieanoe/ieie ci?iaie I, II, III nooiaiy. IV. O?ii?/iee aano?eo c? niieo/aieie aeenieanoe/ieie oa ?aaaia?aoi?ieie ii?ooaiiyie (aeai? i?eaaaeai? a oaae. 1,2,3). Oaaeeoey 1. Ii?oieia?/i? oa ?aaaia?aoi?i? ii?ooaiiy NIO o oai?eo c? cae/aeiei ia?aa?aii ae?aceiai? oai?iae Ii?oieia?/i? ci?ie NIOEiio?ieueia a?oia ? 2 (n=33)IIIIIIIVAAIiaa?oiaaee aano?eo n=126(50,0%)4(33,3%)2(16,6%)--?ioa?noeoe?aeueiee aano?eo n=52(40,0%)2(40,0%)--1(20,0%)Ao?io?/iee aano?eo aac ia?aaoaeiae caeic n=43(75,0%)1(25,0%)- --Ao?io?/iee aano?eo c ia?aaoaeiaith caeic n=61(16,7%)3(50,0%)2(33,3%)--Ao?io?/iee a?ia?iean-oe/iee aano?eo n=63(50,0%)2(33,3%)1(16,7%)--Canoinoaaiiy noi?nii? AIAAI oa EO aeicaiey? ciaioeoe e?euee?noue oa nooi?iue ii?ooaiue ?aaaia?aoi?ieo ci?i, e?ea?aeoaaoe aeoeai?noue caiaeueiiai i?ioeano a NIO oa ?cieueiaai? aeenieac?? I-II nooiaiy. A eiio?ieuei?e a?oi? ?1 aeei?enoaiiy ?cieueiaaii? EO aeicaieeei aeinyaoe oaeeo ci?i eeoa o oai?eo c ao?io?/iei aano?eoii aac- ? c ia?aaoaeiaith caeic. I?e ?ioeo oi?iao aano?eo?a ci?i a ii?oino?oeoo?? NIO o oai?eo oe??? a?oie a?aei?/aii ia aoei. I?iaaaeaii ii??aiyeueiee aiae?c iieaciee?a nooiaiy canaeaiino? neeciai? iaieiiee AAO HP oa oa?aeoa?o ii?oieia?/ieo ci?i o oai?eo iniiaii? oa eiio?ieueii? a?oie ?1 aei oa i?ney e?eoaaiiy. Aei e?eoaaiiy a?aei?/aiee a?eueo aenieee a?aenioie canaeaiino? I? a iniiai?e a?oi? – 65 (83,3%) aeiaaee?a, i?ae a eiio?ieuei?e a?oi? ?1 – 23 (76,7%) aeiaaeea (p<0,05). A iniiai?e a?oi? oai?eo eaaeee nooi?iue canaeaiino? aoa a?aei?/aiee o 18 oai?eo (27,7%), ae?aciee nooi?iue aoa o 47 oai?eo (72,3%). A eiio?ieuei?e a?oi? ? 1 eaaeee nooi?iue canaeaiino? Oaaeeoey 2. Ii?oieia?/i? oa ?aaaia?aoi?i? ii?ooaiiy NIO o oai?eo iniiaii? a?oie aei ? i?ney AIAAI oa EO Ii?oieia?/i? ci?ie NIO A?oie oai?eo ii nooiaith ?aaaia?aoi?ieo ii?ooaiue NIO Aei e?eoaaiiyI?ney e?eoaaiiyIIIIIIIVIIIIIIIVAAAAIiaa?oiaaee aano?eo n=164(25,0%)6(37,5%)3(18,7%)1(6,3%)2(12,5%)6(37,5%)8(50,0%)2(12,5%)--?io a?noeoe?aeueiee aano?eo n=81(12,5%)3(37,5%)2(25,0%)-2(25,0%)2(25,0%)4(50,0%)1(12,5%)-1(12,5%)Ao? io?/iee aano-?eo aac ia?aaoaei-ae caeic n=287(25,0%)10(35,7%)6(21,4%)1(3,6%)4(14,3%)10(35,7%)13(46,4%)3(10,7%)-2 (7,1%)Ao?io?/iee aano-?eo c ia?aaoaei-aith caeic n=20-11(55,0%)6(30,0%)1(5,0%)2(10,0%)1(5,0%)13(65,0%)5(25,0%)-1(5,0%)Ao? io?/iee a?ia?-ieanoe/iee aano-?eo n=62(33,3%)3(50,0%)1(16,7%)--2(33,3%)4(66,7%)--- Oaaeeoey 3. Ii?oieia?/i? oa ?aaaia?aoi?i? ii?ooaiiy NIO o oai?eo eiio?ieueii? a?oie ?1 aei ? i?ney EO Ii?oieia?/i? ci?ie NIO A?oie oai?eo ii nooiaith ?aaaia?aoi?ieo ii?ooaiue NIOAei e?eoaaiiyI?ney e?eoaaiiyIIIIIIIVIIIIIIIVAAAAIiaa?oiaaee aano-?eo n=5 1(20,0%)2(40,0%)2(40,0%)--1(20,0%)2(40,0%)2(40,0%)--?ioa?noeoe?aeueiee aano?eo n=3 1(33,3%)-2(66,7%)--1(33,3%)1(33,3%)1(33,3%)--Ao?io?/iee aano?eo aac ia?aaoaeiae ca-eic n=10 2(20,0%)4(40,0%)3(30,0%)-1(10,0%)3(30,0%)5(50,0%)2(20,0%)--Ao?io?/iee aano?eo c ia?aaoaeiaith ca-eic n=9 3(33,3%)4(44,4%)1(11,1%)1(11,1%)-3(33,3%)4(44,4%)2(22,2%)--Ao?io?/iee a?ia?-ieanoe/iee aano?eo n=3 1(33,3%)1(33,3%)1(33,3%)--1(33,3%)1(33,3%)1(33,3%)-- ae?aaiinoiaaii o 7 iaoe??io?a (30,4%), ae?aciee nooi?iue aoa o 16 iaoe??io?a (69,6%). I?ney AIAAI oa EO, i?iaaaeaii? ia?aeaeueii c aaceniith i?ioeae?aceiaith oa?ai??th, iiaia naiaoe?y neeciai? iaieiiee AAO a iniiai?e a?oi? a?aei?/aia o 41 iaoe??ioa (63,1%) : ?c ieo o 11 (61,0%) c 18 oai?eo c iiia?aaei?i eaaeei nooiaiai canaeaiino? oa o 30 (63,8%) ?c 47 iaoe??io?a c iiia?aaei?i ae?aciei nooiaiai canaeaiino?. A eiio?ieuei?e a?oi? ?1 iiaia naiaoe?y neeciai? iaieiiee AAO aeinyaiooa eeoa o 6 iaoe??io?a: ?c ieo o 2 (28,6%) c 7 oai?eo c iiia?aaei?i eaaeei nooiaiai canaeaiino? oa o 4 (25,0%) c 16 oai?eo c iiia?aaei?i ae?aciei nooiaiai canaeaiino?. Canaeai?noue I? i?ney aeei?enoaiiy AIAAI oa EO caeeoeeany a iniiai?e a?oi? o 24 oai?eo (36,9%): ?c ieo o 7 (10,8%) c 18 oai?eo c iiia?aaei?i eaaeei nooiaiai canaeaiino? (p<0,05) oa o 17 (26,1%) c 47 oai?eo c iiia?aaei?i ae?aciei nooiaiai canaeaiino? (p<0,05). A eiio?ieuei?e a?oi? ?1 canaeai?noue I? caeeoeeany o 17 (73,9%) c 23 oai?eo: ?c ieo o 5 (21,7%) c 7 oai?eo c iiia?aaei?i eaaeei nooiaiai canaeaiino? (p>0,05) oa o 12 (52,2%) c 16 oai?eo c
iiia?aaei?i ae?aciei nooiaiai canaeaiino? (p<0,05). A oe?eiio na?aaei? iieacieee ?I i?e AeIA AeIE o oai?eo iniiaii? a?oie neeaee: aei e?eoaaiiy ?I AAO 3,63±0,35 (iii??ii eenea na?aaeiaeua), ?I OO – 1,21±0,14 (aeoaea eenea na?aaeiaeua); i?ney e?eoaaiiy ?I AAO ??aiyany 4,27±0,46 (iii??ii eenea na?aaeiaeua), ?I OO – 2,28±0,23 (na?aaeiuei eenea na?aaeiaeua). O oai?eo eiio?ieueii? a?oie ?1 iieacieee ?I i?e AeIA AeIE aei e?eoaaiiy neeaee: ?I AAO aoa 3,82±0,41 (iii??ii eenea na?aaeiaeua), ?I OO – 1,37±0,14 (aeoaea eenea na?aaeiaeua); i?ney e?eoaaiiy – ?I AAO ??aiyany 4,1±0,32 (iii??ii eenea na?aaeiaeua), ?I OO – 1,94±0,27 (aeoaea eenea na?aaeiaeua). A eiio?ieuei?e a?oi? ?2 ?I AAO aoa 4,86±0,08 (iii??ii eenea na?aaeiaeua) (p<0,05), ?I OO – 1,44±0,09 (aeoaea eenea na?aaeiaeua) (p<0,05). Iaee?au? ?acoeueoaoe i?e i?iaaaeaii? AIAAI oa EO a?aei?/ai? o oai?eo c eieae?caoe??th ae?acee ia ia?aaei?e no?ioe? oa ii eaoa?aeueiiio eiioo?o. O oe??? a?oie oai?eo a?aei?/athoueny ? iaeiaio? no?iee ?oaoethaaiiy (20,4±0,7 oa 20,7±0,9 aei?a a?aeiia?aeii). Aaae/a anueiai i?ioiaeeei caaithaaiiy ae?acie, ye? eieae?coaaeenue ia caaei?e no?ioe? (22,3±0,5 aei?a) oa ii iaae?aeueiiio eiioo?o (23,3±0,5 aei?a) a?aeiia?aeii. Na?aaei? no?iee ?oaoethaaiiy ae?acie AeIE o oai?eo iniiaii? a?oie neeaee 21,9±1,3 aeiy, o oai?eo eiio?ieueii? a?oie ?1 na?aaei? no?iee ?oaoethaaiiy neeaee 25,6±2,4 aeiy a?aeiia?aeii. AeIA AeIE noi?iaiaeaeothoueny ii?ooaiiyie IAO oeoiea. Io?eiai? aeai? c??aithaaeenue c iieacieeaie aeine?aeaeaiiy 15 i?aeoe/ii caei?iaeo ethaeae, ia iath/eo nea?a c aieo oeoieiai-eeoeiaiai o?aeoo. A eiio?ieueio a?oio ?1 aa?eoee oai??, eio?? iaea?aeoaaee ?cieueiaaio EO (aeai? i?eaaaeai? a oaae. 4). Aeey ioe?iee aaaeoaoi?ii? ooieoe?? oeoiea aeei?enoiaoaaee ne?aeoth/? iieacieee: t – /an ii/aoeo aaaeoaoe?? (a oaeeeiao); T 1/2 – /an iai?aaeaaaeaiiy ?ae? (a oaeeeiao). O oai?eo AeIA AeIE ye iniiaii?, oae ? eiio?ieueii? a?oie ?1 a?aei?/aii ciaioaiiy /ano ii/aoeo aaaeoaoe?? ii c??aiyiith c oaeeie ae aeaieie o a?oi? caei?iaeo in?a (p<0,05). *an iai?aaeaaaeaiiy ?ae? ?c oeoiea o oai?eo c AeIA AeIE aoa iaioei, i?ae a eiio?ieuei?e a?oi? ?1. Aiae?coth/e aeua neacaia, ne?ae a?aei?oeoe, ui o oai?eo AeIA AeIE a iaio a?oiao a?aei?/aii i?enei?aiiy aaaeoaoe?? c oeoiea ca ?aooiie ciaioaiiy /ano ii/aoeo aaaeoaoe?? oa Oaaeeoey 4. Noai iioi?ii-aaaeoaoi?ii? ooieoe?? oeoiea aei e?eoaaiiy ca aeaieie OCAe (M±m) A?oie oai?eot, oaee.O 1/2, oaee.Caei?ia? iniae5,35±0,7433,4±1,47Iniiaia a?oia2,36±0,2521,5±1,23Eiio?ieueia a?oia ?12,57±1,323,3±2,0i?enei?aiiy aaaeoaoe?? a ia?oo oaco (aei aeinyaiaiiy /ano i?aaeaaaeaiiy ?ae?). I?ney e?eoaaiiy ca aeaieie OCAe aeyaeaii iii?oia ciaioaiiy oaeaeeino? aaaeoaoe?? oeoieiaiai ai?noo o oai?eo AeIA AeIE ye iniiaii?, oae ? eiio?ieueii? a?oi (oaae. 5). I?aenoiiaoth/e aeua neacaia, ne?ae a?aecia/eoe, ui o oai?eo AeIA AeIE a?aei?/aii i?enei?aiiy aaaeoaoe?? c oeoiea ca ?aooiie ciaioaiiy /ano ii/aoeo aaaeoaoe?? oa i?enei?aiiy aaaeoaoe?? a ia?oo oaco. I?iaaaeaiiy AIAAI oa EO aeicaiey? ii?iae?coaaoe ii?ooaiiy IAO oeoiea o oai?eo AeIA AeIE, ui, a naith /a?ao, ni?ey? a?eueo oaeaeeiio ?oaoethaaiith ae?acie. Oaaeeoey 5. Noai iioi?ii-aaaeoaoi?ii? ooieoe?? oeoiea i?ney e?eoaaiiy ca aeaieie OCAe (M±m) A?oie oai?eo t, oaee.O 1/2, oaee.Eiio?ieueia a?oia ?13,4 ±1,227,35±3,0Iniiaia a?oia3,52±1,328,4 ±2,1 E?eoa???i ioe?iee a?aeaeaeaieo ?acoeueoao?a aeei?enoaiiy AIAAI oa EO aoei, ia?o ca ana, /anoioa iaca?oaoeueiaaieo oa ?aoeeaeeaieo ae?acie. A no?ie aei iaeiiai ?ieo i?ney i?iaaaeaiiy AIAAI oa EO iacaaeia?euei? ?acoeueoaoe a iniiai?e a?oi? a?aei?/ai? o 28 oai?eo: ia ianoaei ?oaoethaaiiy o 23 (29,5%), ?aoeeaeeae ae?acee aoee o 5 oai?eo (6,4%) a ??ci? no?iee i?ney AIAAI oa EO. Caaaeueiee a?aenioie iacaaeia?eueieo ?acoeueoao?a a iniiai?e a?oi? neeaa 35,9%. A eiio?ieuei?e a?oi? ?1 c AeIA AeIE iacaaeia?euei? ?acoeueoaoe a?aei?/ai? o 17 oai?eo: ia ianoaei ?oaoethaaiiy o 14 oai?eo (46,7%), ?aoeeaeea ae?acee ianoaa o 3 oai?eo (10,0%) a ??ci? no?iee i?ney i?iaaaeaiiy ?cieueiaaii? EO). Caaaeueiee a?aenioie iacaaeia?eueieo ?acoeueoao?a o oe??? a?oie oai?eo neeaa 56,7%. O a?aeaeaeai? no?iee i?ney e?eoaaiiy iacaaeia?euei? ?acoeueoaoe a?aei?/ai? o 4 oai?eo (7,3%) oa o 2 oai?eo eiio?ieueii? a?oie ?1 (10,5%). Caaaeueia e?euee?noue aeia?eo oa a?aei?iieo ?acoeueoao?a o iaoe??io?a iniiaii? a?oie neeaea 80,0% oa 68,4% o oai?eo eiio?ieueii? a?oie ?1. Oaeei /eiii, aeei?enoaiiy AIAAI oa EO aeicaiey? ciaioeoe e?euee?noue oa nooi?iue ii?ooaiue ?aaaia?aoi?ieo ci?i, e?ea?aeoaaoe aeoeai?noue caiaeueiiai i?ioeano a neecia?e iaieiioe? oeoiea oa ?cieueiaai? aeenieac?? I-II nooiaiy. Canoinoaaiiy cai?iiiiiaaii? iaoiaeeee oaeiae ni?ey? cieaeaiith eeneioiooai?aiiy, ii?iae?co? iioi?ii-aaaeoaoi?i? ii?ooaiiy oa ciaioo? canaeai?noue AAO H?, ui, a naith /a?ao, aeicaiey? nei?ioeoe no?iee oa ca?eueoo? a?aenioie ?oaoethaaiiy AeIA AeIE. Iaaoaeoeai?noue AIAAI oa EO, i?iaaaeaii? ia?aeaeueii c aaceniith i?ioeae?aceiaith oa?ai??th c aeei?enoaiiyi aioeaaeoa??aeueieo i?aia?ao?a, neoaeeoue ia’?eoeaiei e?eoa???i iaiao?aeiino? iia?aoeaiiai ao?o/aiiy. AENIIAEE 1. O oai?eo c AeIA AeIE a aeoeai?e noaae?? ia?aa?ao caoai?thaaiiy ia?aaaaea? ae?acia oa ??cei ae?acia caiaeaiiy NIO AeIE, a oie /an ye o iaoe??io?a c? cae/aeiei ia?aa?aii ae?aceiai? oai?iae niinoa??aa?oueny ea?oeia iii??ii ae?aciiai caiaeaiiy a NIO oa AeIE. 2. O oai?eo c AeIA AeIE iathoueny a?eueo aeeaie?, aaaeei cai?ioi? ii?oieia?/i? ci?ie oa ?aaaia?aoi?i? ii?ooaiiy, ye? oa?aeoa?ecothoueny i?iieeiaiiyi caiaeueii-aeeno?io?/ieo i?ioean?a ia anth oiauo NIO oa AeIE, ia a?aei?io a?ae iaoe??io?a c? cae/aeiei ia?aa?aii ae?aceiai? oai?iae, aea oe? ci?ie iaio ae?aaeai?, ?iciianthaeaeothoueny o?eueee ia iiaa?oiaa? oa?e NIO ? iinyoue cai?ioi?e oa?aeoa?. 3. I?e ?oaoethaaii? AeIA AeIE i?ae aieeaii AIAAI oa EO e?ea?aeo?oueny aeoeai?noue caiaeueiiai i?ioeano neeciai? iaieiiee oa ?cieueiaai? aeenieac?? I-II nooiaiy, ciaioo?oueny e?euee?noue oa nooi?iue ?aaaia?aoi?ieo ii?ooaiue a cia/ii a?eueo?e i???, i?ae o oai?eo c AeIA AeIE i?ney aeei?enoaiiy ?cieueiaaii? EO. 4. Aeei?enoaiiy noi?nii? AIAAI oa EO a eiiieaen? c i?ioeae?aceiaith oa?ai??th, aei neeaaeo yei? aeeth/ai? aioeaaeoa?eaeuei? i?aia?aoe, aeicaiey? aeinyaiooe iiaii? naiaoe?? neeciai? iaieiiee AAO a?ae I? o 63,1% iaoe??io?a c AeIA AeIE, ii c??aiyiith c 26,1% o oai?eo c AeIA AeIE i?ney ?cieueiaaiii? EO. 5. O an?o oai?eo c AeIA AeIE caoai?thaaiiy ia?aa?aa? ia oii? i?aeaeuaiiai eeneioiooai?aiiy – na?aaeiaeua a aacaeueieo oiiaao a AAO aoei iii??ii eeneei, a a OO – aeoaea eeneei. Cieaeaiiy eeneioiooai?aiiy a?eueo iii?oia oa iineoue a?eueo o?eaaeee oa?aeoa? o oai?eo c AeIA AeIE i?ney aeei?enoaiiy AIAAI oa EO, i?ae i?ney aeei?enoaiiy ?cieueiaaii? EO. 6. O oai?eo c AeIA AeIE a?aei?/aia i?enei?aia aaaeoaoe?y ?c oeoiea ca ?aooiie nei?i/aiiy /ano ii/aoeo aaaeoaoe??. Aeei?enoaiiy AIAAI oa EO aeicaiey? ii?iae?coaaoe ii?ooaiiy IAO oeoiea o a?eueoino? oai?eo AeIA AeIE. 7. Noi?nia AIAAI oa EO /eieoue aeiaeaoeiaee aieea ? a cia/ii a?eueo?e i??? ni?ey? ii?iae?caoe?? iniiaieo ooieoe?e, ciaioaiith ii?oieia?/ieo ci?i oa cieaeaiith canaeaiino? I?, i?ae ?cieueiaaia EO, ui aeicaiey? i?enei?eoe no?iee ?oaoethaaiiy ae?acie (ia 3,7 aei?a). 8. Aeei?enoaiiy AIAAI oa EO ni?ey? ?oaoethaaiith ae?acie o cia/ii a?eueoi? /anoee oai?eo c AeIA AeIE (70,5% aeiaaee?a), i?ae ?cieueiaaia EO (53,3% aeiaaee?a). 9. Iaaoaeoeai?noue AIAAI oa EO, i?iaaaeaieo ia?aeaeueii c aaceniith i?ioeae?aceiaith oa?ai??th c aeei?enoaiiyi aeieaoi??a I2–?aoeaioi??a aai ?ia?a?oi??a i?ioiiii? iiiie oa aioeaaeoa??aeueieo i?aia?ao?a, neoaeeoue ia?eoeaiei e?eoa???i iaiao?aeiino? iia?aoeaiiai ao?o/aiiy. I?AEOE*I? ?AEIIAIAeAOe?? 1. I?e AeIA AeIE (ae?acee, ye? ia ?oaoeththoueny ia i?ioyc? aeaio oa a?eueoa i?nyoe?a, ?aoeeaeeaoth/? a?eueo aeaio ?ac?a ia ??e aai ae?acee c aacia?a?aii ?aoeeaeeaoth/ith oa/??th), caaaeath/e ia iayai?noue ci?i EOU oa IAO oeoiea, ii?oieia?/i? oa ?aaaia?aoi?i? ii?ooaiiy neeceai? iaieiiee, ye? ?acenoaioi? aei aieeao cae/aeii? i?ioeae?aceiai? oa?ai??, aeeth/ath/i? aeieaoi?e I2–?aoeaioi??a aai ?ia?a?oi??a i?ioiiii? iiiie oa aioeaaeoa??aeueieo i?aia?ao?a, iieacaii ai?iaaaeaeaiiy aenieiaoaeoeaiiai iaoiaeo AIAAI oa EO, yeee /eieoue aeiaeaoeiaee aieea ia aeua aeacai? ci?ie. 2. Aeei?enoaiiy AIAAI oa EO i?e AeIA AeIE ia oii? i?ioeae?aceiai? oa?ai?? c canoinoaaiiyi aeieaoi??a I2–?aoeaioi??a aai ?ia?a?oi??a i?ioiiii? iiiie oa aioeaaeoa??aeueieo i?aia?ao?a aeicaiey? ciaioeoe e?euee?noue ? nooi?iue ii?oieia?/ieo oa ?aaaia?aoi?ieo ii?ooaiue, e?ea?aeoaaoe aeoeai?noue caiaeueiiai i?ioeano oa ?cieueiaai? aeenieac?? I-II nooiaiy, a oaeiae cieceoe canaeai?noue AAO I?. 3. Canoinoaaiiy AIAAI oa EO i?e AeIA AeIE aeicaiey? cieceoe EOO ? ii?iae?coaaoe IAO oeoiea, ui, a naith /a?ao, ni?ey? nei?i/aiith no?ie?a oa ca?eueoaiith a?aenioeo ?oaoethaaiiy AeIA AeIE. 4. Iaaoaeoeai?noue AIAAI oa EO i?e AeIA AeIE, i?iaaaeaieo ia?aeaeueii c aaceniith i?ioeae?aceiaith oa?ai??th c aeei?enoaiiyi aeieaoi??a I2–?aoeaioi??a aai ?ia?a?oi??a i?ioiiii? iiiie oa aioeaaeoa??aeueieo i?aia?ao?a, neoaeeoue ia?eoeaiei e?eoa???i iaiao?aeiino? iia?aoeaiiai ao?o/aiiy. NIENIE IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? I?AOeUe 1. A?ooea A.A., Eaciy N.N., Aoeaaneee N.I. I?eiaiaiea yiaeineiie/aneie iaaeeeaiaioiciie aeieaaeu aeoaeaeathuaai ia?aa a ea/aiee ycaaiiie aieacie. //Eeeie/aneay oe?o?aey. –1996 a. - ?8. – N. 12 – 13. 2. A?ooea A.A., Aoeaaneee N.I., Eaciy N.N., Aaneeueaaa I.A. Iee?ioei?a aeaeoaeea i?e ycaaiiie aieacie e o?iie/aneii aano?eoa. // A?a/aaiia aeaei. –1998. - ?1. – N. 52 – 58. 3. A?ooea A.A., Eaciy N.N., Aoeaaneee N.I. Yiaeineiie/aneea iaoiaeu ea/aiey ycaaiiie aieacie. //A?a/aaiia aeaei. – 1998. - ?2. – N. 3 - 8. 4. A?ooea A.A., Eaciy N.N., Aoeaaneee N.I. Yiaeineiie/aneay iaaeeeaiaioiciay aeieaaea aeoaeaeathueo ia?aia e e?eioa?aiey a ea/aiee aeeeoaeueii iacaaeeaathueo yca aeaeoaeea e aeaaiaaeoeaoeia?noiie eeoee. //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1998. - ?22. – N. 105 - 109. 5. A?ooea A.A., Aoeaaneee N.I., Eaciy N.N. Helicobacter pylori e ioeiciay iee?ioei?a aeaeoaeea i?e oe?o?ae/aneii ea/aiee ycaaiiie aieacie. //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1998. - ?23. – N. 140 - 143. 6. A?ooea A.A., Aoeaaneee N.I., Eaciy N.N. Helicobacter pylori e ioeiciay iee?ioei?a aeaeoaeea i?e ycaaiiie aieacie. //Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1998. - ?25. – N. 16 - 20. 7. A?ooea A.A., Aoeaaneee N.I., Eaciy N.N. Aeieiae/aneia aeaenoaea ieceiyia?aaoe/aneiai eaca?iiai eceo/aiey e e?eioa?aiee ia neecenooth aeaeoaeea i?e ianoiii ea/aiee ycaaiiie aieacie. //Iaoa?eaeu VI ?anioaeeeaineie iao/ii-i?aeoe/aneie eiioa?aioeee “I?eiaiaiea eaca?ia a iaaeeoeeia e aeieiaee”. – Oa?ueeia, 1996 a., N. 64 - 65. 8. A?ooea A.A., Eaciy N.N., Aoeaaneee N.I., Ieeiiaiei O.I. Aeeyiea yiaeineiie/aneie eaca?ioa?aiee ia caaeeaeaiea aeoiaeaiaeueiie ycau e iee?ioei?o aeaeoaeea iinea naeaeoeaiie i?ieneiaeueiie aaaioiiee. //Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? aiaeineii?no?a Oe?a?ie “Aeooaeuei? i?iaeaie ae?aaiinoe/ii? oa e?eoaaeueii? aiaeineii??”. - i. Ee?a, 23-24 o?aaiy, 1996 ?., N. 16-17. 9. A?ooea A.A., Eaciy N.N. Yiaeineiie/aneay iaaeeeaiaioiciay aeieaaea aeoaeaeathuaai ia?aa e e?eioa?aiey a ea/aiee ycaaiiie aieacie. /Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? aiaeineii?no?a Oe?a?ie “Aeooaeuei? i?iaeaie ae?aaiinoe/ii? oa e?eoaaeueii? aiaeineii??”. - i. Ee?a, 23 - 24 o?aaiy, 1996 ?., N.18–19. 10. A?ooea A.A., Eaciy N.N., Aoeaaneee N.I., Oeiea?aiei A.E., Caoaethe A.I. *anoioa auyaeaiey Helicobacter pylori a niiinoaaeaiee n yiaeineiie/aneeie aeaiiuie i?e aano?eoao e ycaaiiie aieacie. //Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? aiaeineii?no?a Oe?a?ie “Aeooaeuei? i?iaeaie ae?aaiinoe/ii? oa e?eoaaeueii? aiaeineii??”. - i. Ee?a, 23 - 24 o?aaiy, 1996 ?., N. 19 - 20. 11. A?ooea A.A., Aoeaaneee N.I., Caoaethe N.A., Eaciy N.N. Ii?aaeaeaiea yaaeoaoi?iie ooieoeee aeaeoaeea i?e yoioiiineiiee. //Nai?iee iao/iuo o?oaeia, Caii?iaeuea, 1996 a., – N. 126 - 127. 12. A?ooea A.A., Eaciy N.N., Aoeaaneee N.I. Yiaeineiie/aneay iaaeeeaiaioiciay aeieaaea aeoaeaeathuaai ia?aa e e?eioa?aiey a ea/aiee ycaaiiie aieacie. //Nai?iee iao/iuo o?oaeia, Caii?iaeuea, 1996 a., - N. 127. 13. A?ooea A.A., Aoeaaneee N.I., Eaciy N.N., Caoaethe A.I., E?eaioaoeeay TH.A., Aa?aaiaay I.A. *anoioa auyaeaiey Helicobacter pylori a niiinoaaeaiee n yiaeineiie/aneeie aeaiiuie i?e ainiaeeoaeueiuo caaieaaaieyo aano?iaeoiaeaiaeueiie ciiu. //Nai?iee iao/iuo o?oaeia, Caii?iaeuea, 1996 a., - N. 127 - 128. AIIOAOe?ss. Eaciy N.N. Aiaeineii?/ia iaaeeeaiaioicia aeieaaea aeoeath/eo ia?a?a oa e??ioa?ai?y a e?eoaaii? aeiaai iacaaithaaieo ae?acie aeaaiaaeoeyoeiaei? eeoee. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.03 – o??o?a?y. – Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y, Aei?i?iiao?ianuee, 1999. Aeena?oaoe?y i?noeoue ?acoeueoaoe aeei?enoaiiy noi?nii? AIAAI oa EO i?e AeIA AeIE oa ?? aieeao ia iniiai? ooieoe?? oeoiea, ii?oieia?/i? ? ?aaaia?aoi?i? ii?ooaiiy, a oaeiae aae?eiaaeoa?io canaeai?noue o 141 oai?iai. Canoinoaaiiy iaoiaeo iaa?oioiaaii iaiao?aei?noth aeiaeaoeiaiai aieeao ia ii?ooaiiy eeneioii?iaeoeoe?eii? oa iioi?ii-aaaeoaoi?ii? ooieoe?e oeoiea, ii?oieia?/i? oa ?aaaia?aoi?i? ci?ie neeciai? iaieiiee, ye? i?e AeIA AeIE noathoue ?acenoaioieie aei aieeao cae/aeii? i?ioeae?aceiai? oa?ai??, aeeth/ath/i? aeieaoi?e I2–?aoeaioi??a aai ?ia?a?oi??a i?ioiiii? iiiie oa aioeaaeoa??aeueieo i?aia?ao?a. Io?eiai? ?acoeueoaoe aeine?aeaeaiiy na?ae/aoue i?i ii?iae?caoe?th iniiaieo ooieoe?e oeoiea, cieaeaiiy e?euee?no? ? nooiaiy ii?oieia?/ieo oa ?aaaia?aoi?ieo ii?ooaiue, aae?eiaaeoa?ii? canaeaiino?, ui ni?eyoeia nei?i/aiith no?ie?a caaithaaiiy ae?acie, a oaeiae i?aeaeuaiith a?aenioeo ?oaoethaaiiy AeIA AeIE. Eeth/ia? neiaa: ae?aceiaa oai?iaa aeaaiaaeoeyoeiaei? eeoee, aeiaai iacaaithaai? ae?acee, iaaeeeaiaioicia aeieaaea aeoeath/eo ia?a?a, e??ioa?ai?y, caaithaaiiy, i?iaiic. AIIIOAOeEss. Eaciy N.N. Yiaeineiie/aneay iaaeeeaiaioiciay aeieaaea aeoaeaeathueo ia?aia e e?eioa?aiey a ea/aiee aeeeoaeueii iacaaeeaathueo yca aeaaiaaeoeaoeia?noiie eeoee. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.03 – oe?o?aey. – Aeiai?iiao?ianeay ainoaea?noaaiiay iaaeeoeeineay aeaaeaiey, Aeiai?iiao?iane, 1999. Aeenna?oaoeey niaea?aeeo ?acoeueoaou i?eiaiaiey ni/aoaiiie YIAAI e EO i?e AeIA AeIE e aa aeeyiea ia iniiaiua ooieoeee aeaeoaeea, ii?oieiae/aneea e ?aaaia?aoi?iua ia?ooaiey, a oaeaea aaeeeiaaeoa?ioth canaeaiiinoue AIAE o 141 aieueiiai. Eniieueciaaiea iaoiaea iainiiaaii iaiaoiaeeiinoueth aeiiieieoaeueiiai aicaeaenoaey ia ia?ooaiey eeneioii?iaeooee?othuae e iioi?ii-yaaeoaoi?iie ooieoeee aeaeoaeea, ii?oieiae/aneea e ?aaaia?aoi?iua eciaiaiey neecenoie iaiei/ee, eioi?ua i?e AeIA AeIE inoathony ?acenoaioiuie e aeaenoaeth iau/iie i?ioeaiycaaiiie oa?aiee, aeeth/athuae aeieaoi?u I2–?aoeaioi?ia eee eiaeaeoi?ia i?ioiiiie iiiiu e aioeaaeoa?eaeueiuo i?aia?aoia. O aieueiuo n AeIA AeIE i?aiaeaaeatho aeoaieea ii?oieiae/aneea eciaiaiey neecenoie iaiei/ee, oa?aeoa?ecothueany i?iieeiiaaieai ainiaeeoaeueii-aeeno?ioe/aneeo eciaiaiee ia anth oieuo neecenoie aeaeoaeea e aeaaiaaeoeaoeia?noiie eeoee, iaia?aoeiinoueth ii?oieiae/aneeo eciaiaiee, ?acee/iuie ?aaaia?aoi?iuie ia?ooaieyie, ioia/aiiuie o 79,6% iaoeeaioia. O yoie aea a?oiiu aieueiuo ioia/ai aieaa aunieee i?ioeaio ianaiaiaiiinoe neecenoie iaiei/ee AIAE I?, iaaethaeaeinue onei?aiea yaaeoaoeee ec aeaeoaeea ca n/ao oiaiueoaiey a?aiaie ia/aea yaaeoaoeee, e onei?aiey yaaeoaoeee a ia?aoth oaco (aei aeinoeaeaiey a?aiaie iieoauaaaeaiey ieue). I?eiaiaiea i?aaeeaaaaiiai niiniaa ea/aiey iicaieeei eeeaeaee?iaaoue aeoeaiinoue ainiaeeoaeueiiai i?ioeanna e eciee?iaaiiua aeenieacee I-II noaiaie, nieceoue eiee/anoai e noaiaiue ia?ooaiee ?aaaia?aoi?iuo i?ioeannia, ii?iaeeciaaoue ia?ooaiey iioi?ii-yaaeoaoi?iie ooieoeee aeaeoaeea, /oi a naith i/a?aaeue niinianoaiaaei aieaa auno?iio ?oaoeaaaieth yca. Iinea YIAAI e EO, i?iaaaeaiiie a eiiieaena n i?ioeaiycaaiiie oa?aieae, aeeth/athuae aioeaaeoa?eaeueiua i?aia?aou, iieiay naiaoeey neecenoie iaiei/ee AIAE aeinoeaiooa o 63,1% aieueiuo iniiaiie a?oiiu, a oi a?aiy eae i?eiaiaiea eciee?iaaiiie e?eioa?aiee iicaieeei aeinoe/ue iieiie naiaoeee neecenoie iaiei/ee eeoue o 26,1% iaoeeaioia eiio?ieueiie a?oiiu. N?aaeiea n?iee ?oaoeaaaiey yca aeaaiaaeoeaoeia?noiie eeoee o aieueiuo iniiaiie a?oiiu ninoaaeee 21,9±1,3 aeiy, a eiio?ieueiie a?oiia n?aaeiea n?iee ?oaoeaaaiey ninoaaeee 25,6±2,4 aeiae niioaaonoaaiii. Iinea ieii/aiey ea/aiey ia ioia/aii ?oaoeaaaiey o 23 (29,5%) aieueiuo iniiaiie a?oiiu, a oi a?aiy eae a eiio?ieueiie a?oiia iinea i?eiaiaiey eciee?iaaiiie e?eioa?aiee ia ianooieei ?oaoeaaaiey o 14 (46,7%) aieueiuo. ?aoeeaeeae?iaaiea ioia/aii a oa/aiea ia?aiai aiaea o 5 (6,4%) iaoeeaioia iniiaiie a?oiiu e o 3 (10,0%) aieueiuo eiio?ieueiie a?oiiu. Iieo/aiiua ?acoeueoaou i?eiaiaiey YIAAI e EO naeaeaoaeuenoaotho i ii?iaeecaoeee iniiaiuo ooieoeee aeaeoaeea, nieaeaiee eiee/anoaa e noaiaie ii?oieiae/aneeo e ?aaaia?aoi?iuo ia?ooaiee, aaeeeiaaeoa?iie ianaiaiaiiinoe, /oi niinianoaoao nie?auaieth n?ieia caaeeaeaiey, a oaeaea iiauoaieth i?ioeaioa ?oaoeaaaiey AeIA AeIE. Iayooaeoeaiinoue YIAAI e EO, i?iaaaeaiiie ia?aeeaeueii n aaceniie i?ioeaiycaaiiie oa?aieae, aeeth/athuae I2–aeieaoi?u eee eiaeaeoi?u i?ioiiiie iiiiu e aioeaaeoa?eaeueiua i?aia?aou, neoaeeo iauaeoeaiui e?eoa?eai iaiaoiaeeiinoe iia?aoeaiiai aiaoaoaeuenoaa. Eeth/aaua neiaa: ycaaiiay aieaciue aeaaiaaeoeaoeia?noiie eeoee, aeeeoaeueii iacaaeeaathuea ycau, iaaeeeaiaioiciay aeieaaea aeoaeaeathueo ia?aia, e?eioa?aiey, caaeeaeaiea, i?iaiic. SUMMARI Lasnia S.S. The Endoscopic Medicamental Blockade of Vagi and Cryotherapy in the Treatment of Protracted non-healing Duodenal Ulcers. – Manuscript. The thesis for the degree of Candidate of Medicine by speciality 14.01.03 – the surgery. – Dniepropetrovsk State Medical Academy, Dniepropetrovsk, 1999. The thesis contains the results of using of combined endoscopic medicamental blockade of vagi and cryotherapy on protracted non-healing duodenal ulcer and their influence on the basic gastric function the morphostructural and regenerative disorders as well as Helicobacter settling of Antral Gastric Portion in 141 patients. The use of the method in motivated by the need of additional influence on the disorders of acid-producing and motor-evacuating gastric function, the morphological and regenerative alterations of mucosa which on protracted non-healing duodenal ulcer an resistant to the common anti-ulcer therapy including H2-receptor blockators ore the inhibitors of proton pomp and the antibacterial preparations. The obtained results testify of the basic gastric function normalization, the reducing of number and degree of morphological and regenerative disorders, the Helicobacter semination which contribute to the shortening of the period of healing as well as to the increasing of scarring percentage of protracted non-healing duodenal ulcer. Key words: duodenal ulcer, protracted non-healing ulcer, medicamental blockade of Vagi, cryotherapy, healing, prognosis. I?aeienaii aei ae?oeo 3.03.99 ?. Oi?iao 60*90/16. Oi. ae?oe. a?e. 1,0. Oe?aae – 100 i?ei. Cai. ? 37 Aeaeaaie/ee oeaio? “Oiiac” i. Caii??aeaey, i?. Eai?ia, 98-a. Oae. 13-84-96

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