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Електрофізіологічні та гемодинамічні ефекти інгібіторів ангіотензинперетворюючого ферменту у хворих на хронічну недостатність кровообігу: Автореф. дис

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OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Eo?’? Na?oeaia C?iia??aia

OAeE: 616.12-008.46-085.225.2

AEAEO?IO?C?IEIA?*I? OA AAIIAeEIAI?*I? AOAEOE

?IA?A?OI??A AIA?IOAICEIIA?AOAI?THTH*IAI OA?IAIOO

O OAI?EO IA O?II?*IO IAAeINOAOI?NOUe E?IAIIA?AO

14.01.11 – Ea?ae?ieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? oa?ai?? AII Oe?a?ie, i.Oa?e?a.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe

I?eieaiei ?aaai sseiae/,

?inoeooo oa?ai?? AII Oe?a?ie, i.Oa?e?a,

canooiiee aee?aeoi?a c iaoeiai?
?iaioe

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Eaoiaoc ?aai E?iae?aoiae/,

Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao,

caa?aeoaa/ eaoaae?e aioo??oi?o oai?ia, NI ? EOE;

eaiaeeaeao iaaee/ieo iaoe, aeioeaio

Oonoaaeue Ieeiea Oaaei?iae/,

Oa?e?anueeee ?inoeooo oaeineiiaeaiiy e?ea??a,

caa?aeoaa/ eaoaae?e ee?i?/ii? ea?ae?ieia?? ?

ooieoe?iiaeueii? ae?aaiinoeee

I?ia?aeia onoaiiaa: Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo

ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea

IIC Oe?a?ie, a?aeae?eaiiy aoa?ineea?ico

? o?ii?/ii? ?oai?/ii? oai?iae
na?oey, i.Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 28 ” n?/iy 1999 ?. i 13 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca
aae?anith:310022, i.Oa?e?a, i?.Eai?ia, 4.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai

iaaee/iiai oi?aa?neoaoo (310022, i.Oa?e?a, i?.Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee “18” a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeioeaio Ia/a?aiei E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. O?ii?/ia iaaeinoaoi?noue e?iaiia?ao (OIE) ?
iaei??th c i?ia?aeeo i?iaeai no/anii? ea?ae?ieia??. Aiia
oa?aeoa?eco?oueny aeniaaeaiiyi ?aca?aieo iiaeeeainoae i?iea?aea oa
nenoaiieo eiiiainaoi?ieo iaoai?ci?a. A ?? ?icaeoeo aaaeo/o ?ieue
a?ae?a?athoue ii?ooaiiy iae?iaoii?aeueieo ? ee?oeiii-iaoaaie?/ieo nenoai
?aaoeyoe?? (Iaea E. O., 1997).

Iacaaaeath/e ia aeinyaiaiiy inoaii?o ?ie?a o aea/aii?
iaoio?c?ieia?? o?ii?/ii? iaaeinoaoiino? e?iaiia?ao, neioaco iiaeo a?oi
i?aia?ao?a, a?eueo ei?aeoiiai canoinoaaiiy o?aaeeoe?eieo e?ea?nueeeo
cania?a, aiia caeeoa?oueny iaei??th c iaea?eueo ?iciianthaeaeaieo i?e/ei
na?oeaai-noaeeiii? caoai?thaaiiino? e nia?oiino? a onueiio na?o? (Yusuf
G., Lonn E. M., 1994; Pfeffer M. A., 1996).

Iniaeeaa oaaaa aeine?aeiee?a i?eae?ey?oueny aea/aiith
aeaeo?iea?ae?io?c?ieia?/ii? aeoeaiino? aeey aecia/aiiy /?oeeo e?eoa???a
ooieoe?iiaeueiiai noaio i?iea?aea caniaaie AEA – aenieiai i?aeneeaiiy,
niaeo?aeueii-oei/aniaiai ea?ooaaiiy, ioe?iee aa??aaaeueiino? na?oeaaiai
?eoio, ui ia? aaaeeeaa cia/aiiy ye aeey ?icoi?iiy iaoiaaiaoe/ieo
iaoai?ci?a, oae ? aeey ?ic?iaee ?aoe?iiaeueieo oeyo?a oa?iaeieia?/ii?
ei?aeoe?? o?ii?/ii? iaaeinoaoiino? e?iaiia?ao (Beny J. L., Brunet P. C.,
1994; El–Sherif N., 1995).

Ii?ooaiiy, ui aeyaeythoueny i?e aeaeo?iea?ae?io?c?ieia?/ieo
aeine?aeaeaiiyo, a?ae?a?athoue i?ia?aeio ?ieue aeey ?icoi?iiy iaoiaaiaco
OIE. A ca’yceo c oeei aeine?aeaeaiiy aieeao e?ea?nueeeo i?aia?ao?a ia
aeaeo?e/io aeoeai?noue i?iea?aea aoaea ni?eyoe eiiieaeniiio ?icoi?iith
iaoiaaiaoe/ieo iaoai?ci?a OIE ? aaeineiiaeaiith oa?iaeieia?/ii?
ei?aeoe?? iaaeinoaoiino? e?iaiia?ao.

Aaaeeeaei a ioe?ioe? ee?i?/iiai e i?iaiinoe/iiai cia/aiiy OIE ?
?icoe?aii? iiaeeeainoae ?? aeeoa?aioe?eiaaii? oa?ai?? ? aea/aiiy
oa?aeoa?o aeenooieoe?? e?aiai oeoii/ea (EO). Iiiyooy aeenooieoe?? EO
anioe?thaaeinue ?ai?o eeoa c? ci?iith nei?ioeeai? ooieoe?? i?iea?aea oa
cieaeaiiyi o?aeoe?? aeeeaeo. Anoaiiaeaii, ui na?oeaaa iaaeinoaoi?noue
iaeaea caaaeaee aeeth/a? eiiiiiaio ae?anoie?/ii? aeenooieoe??, a o
aeayeeo oai?eo (a?ia?o?io?/iith ea?ae?ii?iiao??th, ia ?oai?/io oai?iao
na?oey (?ON) c a?oa??aeueiith a?ia?oii??th) aiia ? iniiaiith
ooieoe?iiaeueiith iaoieia??th. A ca’yceo c oeei aeioe?eueii aeyaeyoe
ae?anoie?/io aeenooieoe?th aeey ?? iaaeeeaiaioicii? ei?aeoe??.

Canoinoaaiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo (AIO)
aeoiaeeoue ia aaaeo/a i?noea a oa?ai?? oai?eo o?ii?/iith iaaeinoaoi?noth
e?iaiia?ao. Ii ?acoeueoaoai aaaaoioeaio?iaeo aeine?aeaeaiue (SOLVD,
1991, 1992; SAVE, 1992; CONSENSUS, 1987 oa ?i.) oe? i?aia?aoe ni?eythoue
ciaioaiith caaaeueii? eaoaeueiino? oa /anoioe nia?o? a?ae o?ii?/ii?
iaaeinoaoiino? e?iaiia?ao, a oiio /ene? ? o oai?eo, ye? ia?aianee
?ioa?eo i?iea?aea (AIRE, 1993; TRACE, 1995 oa ?i.).

?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo ciaeoee oe?iea
canoinoaaiiy a e?eoaaii? o?ii?/ii? iaaeinoaoiino? e?iaiia?ao, ine?eueee
aiie ?aaoeththoue ii?ooai? iae?iaoii?aeuei? aca?iia?aeiineie a
i?aai?ci?, neiiaoiaae?aiaeiao, ?ai?i-aia?ioaicei-aeueaeinoa?iiiao
nenoaie oa eae?e?a?i-e?i?iiao nenoaio, a oaeiae ? ia?eoa?e/ieie
aaciaeeeaoaoi?aie ci?oaiiai oeio.

Ne?ae a?aecia/eoe, ui iaoiaee i?iaiico oa aoaeoeaiino? oa?ai?? OIE, ye?
canoiniaothoueny a oaia?aoi?e /an, e?euee?nii ia a?aoiaothoue
aeaeo?io?c?ieia?/i? aeanoeaino? i?iea?aea. Ia ?ic?iaeai? aeeoa?aioe?ei?
i?aeoiaee aei oa?iaeioa?ai?? OIE ?ia?a?oi?aie AIO ia i?aenoaa?
aeo?aeiiai noaio aeaeo?io?c?ieia?/ii? aeoeaiino? i?iea?aea.

Aeyaeaiiy aoaeo?a oa?ai?? ?ia?a?oi?aie AIO i?e OIE ia
aeaeo?io?c?ieia?/iee noai i?iea?aea oa ia?aiao?e iae?iaoii?aeueii?
aeoeaiino? i?aaenoaaeythoue iaoeiaee oa i?aeoe/iee ?ioa?an a
ea?ae?ieia??, ui ? noaei i?aaeiaoii aeaiiai aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aea?aiee iai?yiie aeine?aeaeaiue iia’ycaiee c iaoeiaith ae?yeuei?noth oa
aoiaeeoue aei oaiaoe/iiai ieaio ?inoeoooo oa?ai?? AII Oe?a?ie, ye
o?aaiaio iaoeiai-aeine?aeieoeueei? ?iaioe: “Aea/eoe iaoiaaiaoe/ia
cia/aiiy oa ?ic?iaeoe e?eoa??? ae?aaiinoeee oa i?iaiicoaaiiy na?oeaai?
iaaeinoaoiino? o oai?eo ia ?oai?/io oai?iao na?oey oa ?ic?iaeoe e
cai?iiiioaaoe iaoiaaiaoe/i? noaie ?? iaaeeeaiaioiciiai e?eoaaiiy ?c
canoinoaaiiyi ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo oa
aioaaii?no?a ?aoeaioi??a aia?ioaiceio ??” – ?aa.? 0197U008307.

Iaoa ? caaea/? aeine?aeaeaiiy.

Iaoith ?iaioe ? i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy OIE ia i?aenoaa?
ioe?iee aeaeo?io?c?ieia?/ieo aeanoeainoae i?iea?aea oa
ea?ae?iaaiiaeeiai?ee, aca?iica’yceo ?o c iae?iaoii?aeueieie iaoai?ciaie
a i?ioean? oa?ai?? ?ia?a?oi?aie AIO.

Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaea/?:

Ioe?ieoe nenoie?/io oa ae?anoie?/io ooieoe?? i?iea?aea niiniaaie
niaeo?aeueiiai aiae?co aeaeo?io?c?ieia?/ieo iieaciee?a ?
aeiiea?aoiea?ae?ia?ao?? o in?a a?oie eiio?iey e o oai?eo ia OIE.

Noi?ioethaaoe ocaaaeueiai? ?ioaa?aeuei? aeaeo?io?c?ieia?/i? e?eoa???
?aiiuei? ae?aaiinoeee OIE.

I?iaanoe eiiieaenio ioe?ieo aieeao ?ia?a?oi??a AIO ia
aeaeo?io?c?ieia?/i? aeanoeaino? i?iea?aea oa ae?anoie?/io ooieoe?th
e?aiai oeoii/ea.

Aecia/eoe aca?iica’ycie i?ae iieacieeaie aeaeo?io?c?ieia?/ii? oa
iae?iaoii?aeueii? (aacii?anei, aiaeioae?i-1, IIOO) aeoeaiino? a
aeeiai?oe? e?eoaaiiy ?ia?a?oi?aie AIO oai?eo ia OIE.

Aecia/eoe aoaeoeai?noue e?eoaaiiy OIE ?ia?a?oi?aie AIO a
?iaeea?aeoaeueii i?ae?a?aieo aeicao c o?aooaaiiyi anoaiiaeaieo
ae?aaiinoe/ieo e?eoa???a.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aeyaeaii caeaaei?noue ae?anoie?/ii? oa nenoie?/ii? aeenooieoe??
i?iea?aea e?aiai oeoii/ea ii aeaiei niaeo?aeueiiai aiae?co
aeaeo?io?c?ieia?/ieo aeine?aeaeaiue oa aeiiea?aoiea?ae?ia?ao?? a?ae
oyaeeino? ee?i?/iiai ia?aa?ao OIE.

?ic?iaeaii ?ioaa?aeuei? ae?aaiinoe/i? e?eoa??? ia iniia? ocaaaeueiaii?
ii?iiaaii? niaeo?aeueii? iiooaeiino?.

Cai?iiiiiaaia iiaeaeue ioe?iee iieaciee?a niaeo?aeueii?
aeiiea?-aoiea?ae?ia?ao?? a ii?i? oa i?e OIE ??ciiai nooiaiy oyaeeino?.

Anoaiiaeaii iniaeeaino? ci?ie iieaciee?a o?aini?o?aeueiiai e?iaia?ao oa
aoiea?ae?ia?ao?? a aeeiai?oe? e?eoaaiiy OIE ?ia?a?oi?aie AIO o
c?noaaeaii? c aoaeoeai?noth aacenii? oa?ai??.

Aia?oa aecia/aii ca aeiiiiiaith niaeo?aeueiiai aiae?co e?eoa???
?iaeea?aeoaeueii? ioe?iee i?iaiico oa aoaeoeaiino? oa?ai?? OIE
?ia?a?oi?aie AIO.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Anoaiiaeaia aaaeeeaa i?aeoe/ia ?ieue aecia/aiiy ae?anoie?/ii?
aeenooieoe?? oa aeaeo?io?c?ieia?/ieo aeanoeainoae i?iea?aea o oai?eo ia
OIE, ?oi?e aca?iica’ycie c iae?iaoii?aeueieie ia?aiao?aie, ui aeicaiey?
i?aeaeueoe ye?noue ?aiiuei? ae?aaiinoeee.

?ic?iaeai? iaoiaeeee e e?eoa??? aeicaieythoue ee?i?oeenoo ia’?eoecoaaoe
i?iaiic oa aoaeoeai?noue e?eoaaiiy.

Cai?iiiiiaai? ae?aaiinoe/i? e?eoa??? ioe?iee noaio i?iea?aea iiaeooue
aooe ?aeiiaiaeiaai? aeey i?aeoe/iiai aeei?enoaiiy a eiii’thoa?ieo
ea?ae?ieia?/ieo nenoaiao.

?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy ai?iaaaeaeai? o i?aeoe/io ?iaioo
ee?i?ee ?inoeoooo oa?ai?? AII Oe?a?ie, e?eoaaeueieo caeeaae?a
I?i?noa?noaa Aioo??oi?o Ni?aa (IAN) Oe?a?ie: iie?ee?i?ee oi?aae?iiy IAN
i.Oa?eiaa, iie?ee?i?ee oa aini?oaeth oi?aae?iiy IAN i. Aeiiaoeueea oa
iaeano?, iie?ee?i?ee oa aini?oaeth oi?aae?iiy IAN i. ?aaii-O?aie?anueea
oa iaeano?; e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a IIC Oe?a?ie:
Eoi’yinueei? oeaio?aeueii? ?aeiiii? e?ea?i? Oa?e?anueei? iaeano? oa
Aeia?ii?euenueei? oeaio?aeueii? ?aeiiii? e?ea?i? Aeiiaoeueei? iaeano? .

Iniaenoee aianie caeiaoaa/a.

Naiino?eii cae?enithaaea ianoaaeaiiy oa i?aea?? oai?eo ia OIE c
aeei?enoaiiyi ee?i?ei-?ino?oiaioaeueieo oa eaai?aoi?ieo iaoiae?a,
i?aea?? ae?oa?aioe?eiaaii? oa?ai?? oa eiio?ieue ca aoaeoeai?noth
e?eoaaiiy.

Canoiniaoaaea oae? iaoiaee aeine?aeaeaiiy oai?eo:
aeiiea?aoiea?ae?ia?ao?th, aecia/aiiy eiioeaio?aoe?? a ieaci? e?ia?
aacii?aneio, IIOO, aiaeioaeiio-1 ?aaeiiiioiieiai/iei iaoiaeii,
aecia/aiiy iiaeeaiaeoaeueio? oa?aiaaoe/ii aoaeoeaii? aeice i?aia?aoo
eeiiiei-iioiieiai/iei iaoiaeii O-aeoeaiiai ?icaoeiooai?aiiy oa
aecia/aiiy ocaaaeueiaieo ?ioaa?aeueieo aeaeo?ioiciieiai/ieo ia?aiao?ia
iiiea?aea ca aeiiiiiaith eiii’thoa?ii? aeaeo?iea?aeiia?aoi? oa iioa.

Aaoi? iniaenoi aecia/aea iaoo oa ieaioaaea caaaeaiiy aeineiaeaeaiiy,
i?iaiaeeea aiaeic oa iaoaiaoe/io ia?iaeo io?eiaieo ?acoeueoaoia c
aeei?enoaiiyi aeaeo?iiii-ia/enethaaeueii? oaoi?ee, ioi?iethaaea
aeena?oaoe?eio ?iaioo.

Ai?iaaoe?y ?iaioe.

Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ? iaaiai?thaaeenue ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo ?inoeoooo oa?ai?? AII Oe?a?ie
(1996-1998), ?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? iieiaeeo
a/aieo oa oao?aoe?a “No/ani? ooiaeaiaioaeuei? oa i?eeeaaei? i?iaeaie a
ee?i?oe? aioo??oi?o caoai?thaaiue” (Oa?e?a, 1997), ia Ia?oiio
i?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a oa iieiaeeo a/aieo
(Oa?iii?eue, 1997), Neiiic?oi? naeoe?? NIAe i?aeia?iaeiiai oiaa?enoaa ii
aea/aiith na?oey (Iineaa, 1997). Aieiai? iieiaeaiiy aeena?oaoe?? aoee
i?aaenoaaeai? ia Anana?oiueiio eiia?an? iaaee/ii? o?ceee oa a?iiaaee/ii?
?iaeaia??? (??i aea AEaiae?i, 1993), ia 4 I?aeia?iaei?e eiioa?aioe?? ii
ia?iaaceai?e ea?ae?ieia?? (E?i?, 1993), ia XX Eiia?an? ?a?iiaenueeiai
oiaa?enoaa ea?ae?ieia?a (A?aeaiue, 1998).

?acoeueoaoe ?iaioe “Niaeo?aeueiee aiae?c AEA a ioe?ioe?
ooieoe?iiaeueiiai noaio na?oey” a?aecia/ai? Iaaeaeeth “Ca e?auo
nooaeaionueeo iaoeiao ?iaioo 1993 ?ieo”. Aaoi? oe??? ?iaioe noaea
eao?aaoii i?ai?? Iaoe?iiaeueii? Aeaaeai?? Iaoe aeey nooaeaio?a aeueo
o/aiaeo caeeaae?a 1993 ?ieo.

Ioae?eaoe??.

Ii oai? aeena?oaoe?eii? ?iaioe iioae?eiaaii 14 ?ia?o, c yeeo 7 – o
iaoeiaeo aeo?iaeao, 6 – aac ni?aaaoi??a. Ca iaoa??aeaie aeena?oaoe??
io?eiaii iaoaio ia aeiao?ae “Niin?a ioe?iee ooieoe?iiaeueiiai noaio
na?oey” ? 2067417.

No?oeoo?a oa ianya aeena?oaoe??.

Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 190 noi??ieao iaoeiiieniiai oaenoo e
neeaaea?oueny c anooio, 3 ?icae?e?a, ui aeeth/athoue iaeyae e?oa?aoo?e,
aeani? aeine?aeaeaiiy, iaaiai?aiiy io?eiaieo ?acoeueoao?a, a oaeiae
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae.
A?ae?ia?ao?/iee iieaae/ee i?noeoue 352 aeaea?aea, c ieo 65 – ia
oe?a?inuee?e oa ?in?enuee?e iiaao, 282 ca?oa?aeieo aeaea?ae. ?iaioa
?ethno?iaaia 13 ?enoieaie (ianyaii 13 noi?.) oa 15 oaaeeoeyie (ianyaii
10 noi?.).

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy.

Ia’?eoii aeine?aeaeaiiy aoee 118 oai?eo c o?ii?/iith iaaeinoaoi?noth
e?iaiia?ao, ye? ciaoiaeeeenue ia ianoaaeaii? oa e?eoaaii? a ee?i?oe?
?inoeoooo oa?ai?? AII Oe?a?ie. Na?aae ieo aoei 98 /ieia?e?a (83%) ? 20
ae?iie (17%) o a?oe? a?ae 33 aei 74 ?ie?a. Na?aaei?e a?e ianoaaeaieo
noaiiaea 54,2( 4,8 ?ieo. Eiio?ieueio a?oio neeaee 26 i?aeoe/ii caei?iaeo
in?a o a?oe? a?ae 25 aei 52 ?ie?a (na?aaei?e a?e 40(7 ?ie?a).

Ca eeaneo?eaoe??th Iueth-Ei?enueei? anioe?aoe?? na?oey (NYHA) iciaee
iaaeinoaoiino? e?iaiia?ao I ooieoe?iiaeueiiai eeano (OE) aecia/aeeny o
28 oai?eo (23%), II – o 67 (57%), III – o 23 oai?eo (20%). O?eaae?noue
OIE o 76 (64%) oai?eo aoea aei 5 ?ie?a, a o 42 (36%) – iiiaae 5 ?ie?a.

OIE ?icaeeanue aiane?aeie ?ON o 38 oai?eo (32%), ?ON c iino?ioa?eoiei
ea?ae?ineea?icii (aeaai?noue inoaiiueiai aino?iai ?ioa?eoa i?iea?aea –
ia iaio iaeiiai ?ieo) o 37 oai?eo (32%), o 13 oai?eo (11%) aiane?aeie
a?ia?oii?/ii? oai?iae, o 24 (20%) – a?ia?oii?/ii? oai?iae ia oii? ?ON,
aeeeaoaoe?eii? ea?ae?ii?iiao?? o 6 oai?eo (5%).

I?e aiae?c? /eiiee?a ?eceeo OIE iaea?eueo /anoi cono??/aeeny:
a?ia?e?i?aeai?? (18%), o?eaaeee noaae ?ON (42%), ia?aianai? ?ioa?eoe
i?iea?aea (31%), a oiio /ene? ii?aeiaiiy aeae?eueeio /eiiee?a. Na?aae
oe?aeeeaeo cae/ie iaea?eueo /anoi cono??/aeeny iae?iiy – 61 ethaeeia
(52%), caaaeueiee noaae iae?iiy aa??thaaa o iaaeao a?ae 7 aei 41 ?ieo
(21(2 ?ieo), na?aaeiy e?euee?noue aeiaeaieo ca aeiao neaa?ao neeaea
12,3(4,0. Aaeeaaiiy aeeiaiey a aiaiiac? aeeooy i?inoaaeoaaeinue o 81
(69%) oai?iai. Iaee??iiyi (?iaeaen Eaoea > 30,0) no?aaeaeaei 13 /ieia?e
(11%), oeoe?iaei ae?aaaoii 4 (3%) oai?eo, iaei?ooiiee niin?a aeeooy aaee
59 (50%) oai?eo.

A iaoa aeine?aeaeaiiy ia aeeth/aeeny oai?? c o?ii?/iith iaaeinoaoi?noth
e?iaiia?ao iiiaae ??? OE, c noi?ia?aeieie caoai?thaaiiyie, ui iiaee a
nooo?ai aieeiooe ia i?iaiic ? aeiaaaee niaoe?aeueiiai iaaeeeaiaioiciiai
e?eoaaiiy: c ae?aaeaieie ii?ooaiiyie ?eoio, ?acenoaioiith a?oa??aeueiith
a?ia?oaic??th, oeoe?iaei ae?aaaoii aaaeeiai ia?aa?ao, aeoeaiith oacith
?aaiaoecio.

An? oai?? aoee ?aoaeueii ee?i?/ii ianoaaeai?. Ooieoe?iiaeueiee noai
i?iea?aea ioe?ithaaee niiniaii niaeo?aeueiiai aiae?co aia?aaoe/iiai
??aiy i?iea?aea ia ?ioa?aaeao aeaiiey?ecaoe?? oa ?aiiey?ecaoe?? (Iaea
E.O. e ni?aaao., 1996) c ?a?no?aoe??th ii?oieia?/ieo aeaiaio?a AEA, c
ianooiiei aeae?eaiiyi ?ioa?aae?a P-Q+QRS oa ST-T+T-P, aecia/aiiyi
ae?aaiinoe/iiai e?eoa??th (Aee). I?e cia/aii? Aee, ??aiei aai iaioei
0,4, a oaeiae ??aiei aai a?eueoei 0,6 i??eothoue i?i ii?ooaiiy
ooieoe?iiaeueiiai noaio i?iea?aea. Aeiaeaoeiai aeae?eai? ?ioa?aaee AEA
aeei?enoiaoaaee aeey aecia/aiiy e?eoa??th aia?aaoe/iiai ??aiy i?iea?aea,
oiaoi iioaioe?eii? ae??caeaoiino? na?oey. ?ioa?aae P-Q+QRS
oa?aeoa?eco? o?eaae?noue caoaeaeaiiy ia?aaena?aeue oa oeoii/e?a
na?oey ia noaae?? aeaiiey?ecaoe??, ?ioa?aae ST-T+T-P –
o?eaae?noue ?icneaaeaiiy i?iea?aea ia?aaena?aeue, oeoii/e?a ia noaae??
?aiiey?ecaoe??.

Aaiiaeeiai?/i? ia?aiao?e ioe?ithaaee iaoiaeii aoiea?ae?ia?ao?? ia
aia?ao? “Aloka” SSD-280 (ssiii?y) ca caaaeueiii?eeiyoith iaoiaeeeith.
Aecia/aee ianooii? iieacieee: e?ioeaaee ae?anoie?/iee ?ici?? (EAe?),
e?ioeaaee ae?anoie?/iee ia(?i (EAeI), e?ioeaaee nenoie?/iee ?ici??
(EN?), e?ioeaaee nenoie?/iee ia(?i (ENI), oaeaee?noue oee?eoey?iiai
oei?i/aiiy aieieii i?iea?aea (OOeO), nooi?iue oei?i/aiiy
ia?aaeiuei-caaeiueiai ?ici??o e?aiai oeoii/ea (NO), o?aeoe?y aeeeaeo
(OA), oaea?iee ia(?i (OI).

Aeiiea?aoiea?ae?ia?ao?th ia aia?ao? SIM 5000 Plus (“Biomedica”, ?oae?y)
i?iaiaeeee aeey aea/aiiy noaio ae?anoie?/ii? aeenooieoe?? e?aiai
oeoii/ea oeyoii ioe?iee ia?aiao??a ae?anoie?/iiai o?aini?o?aeueiiai
e?iaia?ao (AeOIE). Aecia/aee iaeneiaeueio oaeaee?noue e?iaia?ao
?aiiueiai ae?anoie?/iiai iaiiaiaiiy EO (I1) oa iaeneiaeueio oaeaee?noue
e?iaia?ao a nenoieo ia?aaena?aey (I2), aeiiea?ianueeee ?iaeaen I1/I2. Ca
niaeo?ii aeiiea?ianueeeo /anoio AeOIE aecia/aee ?ioaa?aeueio oaeaee?noue
?aiiueiai ae?anoie?/iiai iaiiaiaiiy (E) oa ?ioaa?aeueio oaeaee?noue
i?ciueiai ae?anoie?/iiai iaiiaiaiiy (A), eiao?oe??io A/A.

?iaeaen ?iaeea?aeoaeueii? /ooeeaino? aei e?ea?nueeiai i?aia?aoo
(aiaeai?eeo) aecia/aee ee?i?ei-?ioiieia?/iei iaoiaeii aeoeaiiai
?icaoeiooai?aiiy O-e?ioioeeo?a c a?eo?ioeeoaie aa?aia, ianooiiei
ia/eneaiiyi oa?aiaaoe/ii aoaeoeaii? aeiaiai? aeice (Ia?aaea?ee A.A.,
Caineia A.I., Ai?/eiaa I.A., 1995).

Ai?no aiaeioae?ia-1, ia?aaena?aeiueiai iao??eo?aoe/iiai oaeoi?a (IIOO),
aacii?aneia aeyaeyee ?aae?i?ioiieia?/iei iaoiaeii ca aeiiiiiaith
noaiaea?oieo iaai??a o??ie DRG (NOA).

An? ?acoeueoaoe aeine?aeaeaiiy aoee ia?iaeai? ca aeiiiiiaith iaoiaeo
aa??aoe?eii? noaoenoeee ia ia?niiaeueiiio eiii’thoa?? c ia/eneaiiyi
na?aaeiuei? aaee/eie I, na?aaeiueieaaae?aoe/iiai a?aeoeeaiiy (,
na?aaeiuei? iiieeee na?aaeiuei? aaee/eie m, e?eoa??th a??ia?aeiino? t,
cia/aiiy a??ia?aeiino? ?. A?aei?iiino? i?ae iieacieeaie, ui
ii??aiththoueny, c?ciaaaeenue a??ia?aeieie, yeui cia/aiiy ?iia??iino?
aoei a?eueoei aai ??aii 95% (?0,05). Ia?aeaeueii c ieie ciaiooaaeenue ? ia(?ii?
iieacieee EAeI ia 5,6% (?>0,05) ? ENI ia 12,4% (? NEI?I*AIIss A - ?ioaa?ae oaeaeeino? ia??iaeo i?ciueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea AIO - aia?ioaiceiia?aoai?thth/ee oa?iaio Aee - ae?aaiinoe/iee e?eoa??e AeOIE - ae?anoie?/iee o?aini?o?aeueiee e?iaia?a A - ?ioaa?ae oaeaeeino? ia??iaeo ?aiiueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea AEA - aeaeo?iea?ae?ia?aia AONE - aeaeo?io?c?ieia?/iee niaeo?aeueiee e?eoa??e ?ON - ?oai?/ia oai?iaa na?oey EAeI - e?ioeaaee ae?anoie?/iee ia(?i EAe? - e?ioeaaee ae?anoie?/iee ?ici?? ENI - e?ioeaaee nenoie?/iee ia(?i EN? - e?ioeaaee nenoie?/iee ?ici?? EO - e?aee oeoii/ae I1 - iaeneiaeueia oaeaee?noue ?aiiueiai ae?anoie?/iiai iaiiaiaiiy EO I2 - iaeneiaeueia oaeaee?noue e?iaia?ao a nenoieo ia?aaena?aey IIOO - ia?aaena?aeiee iao??eo?aoe/iee oaeoi? NO - nooi?iue oei?i/aiiy ia?aaeiuei-caaeiueiai ?ici??o EO OI - oaea?iee ia(?i OA - o?aeoe?y aeeeaeo OE - ooieoe?iiaeueiee eean OIE - o?ii?/ia iaaeinoaoi?noue e?iaiia?ao OOeO - oaeaee?noue oee?eoey?iiai oei?i/aiiy aieieii i?iea?aea IIOO Aiaeioae?i - 1 Aacii?anei NO OA EAeI ENI

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