OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Eo?’? Na?oeaia C?iia??aia

OAeE: 616.12-008.46-085.225.2

AEAEO?IO?C?IEIA?*I? OA AAIIAeEIAI?*I? AOAEOE

?IA?A?OI??A AIA?IOAICEIIA?AOAI?THTH*IAI OA?IAIOO

O OAI?EO IA O?II?*IO IAAeINOAOI?NOUe E?IAIIA?AO

14.01.11 – Ea?ae?ieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? oa?ai?? AII Oe?a?ie, i.Oa?e?a.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe

I?eieaiei ?aaai sseiae/,

?inoeooo oa?ai?? AII Oe?a?ie, i.Oa?e?a,

canooiiee aee?aeoi?a c iaoeiai?
?iaioe

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Eaoiaoc ?aai E?iae?aoiae/,

Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao,

caa?aeoaa/ eaoaae?e aioo??oi?o oai?ia, NI ? EOE;

eaiaeeaeao iaaee/ieo iaoe, aeioeaio

Oonoaaeue Ieeiea Oaaei?iae/,

Oa?e?anueeee ?inoeooo oaeineiiaeaiiy e?ea??a,

caa?aeoaa/ eaoaae?e ee?i?/ii? ea?ae?ieia?? ?

ooieoe?iiaeueii? ae?aaiinoeee

I?ia?aeia onoaiiaa: Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo

ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea

IIC Oe?a?ie, a?aeae?eaiiy aoa?ineea?ico

? o?ii?/ii? ?oai?/ii? oai?iae
na?oey, i.Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 28 ” n?/iy 1999 ?. i 13 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca
aae?anith:310022, i.Oa?e?a, i?.Eai?ia, 4.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai

iaaee/iiai oi?aa?neoaoo (310022, i.Oa?e?a, i?.Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee “18” a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeioeaio Ia/a?aiei E.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. O?ii?/ia iaaeinoaoi?noue e?iaiia?ao (OIE) ?
iaei??th c i?ia?aeeo i?iaeai no/anii? ea?ae?ieia??. Aiia
oa?aeoa?eco?oueny aeniaaeaiiyi ?aca?aieo iiaeeeainoae i?iea?aea oa
nenoaiieo eiiiainaoi?ieo iaoai?ci?a. A ?? ?icaeoeo aaaeo/o ?ieue
a?ae?a?athoue ii?ooaiiy iae?iaoii?aeueieo ? ee?oeiii-iaoaaie?/ieo nenoai
?aaoeyoe?? (Iaea E. O., 1997).

Iacaaaeath/e ia aeinyaiaiiy inoaii?o ?ie?a o aea/aii?
iaoio?c?ieia?? o?ii?/ii? iaaeinoaoiino? e?iaiia?ao, neioaco iiaeo a?oi
i?aia?ao?a, a?eueo ei?aeoiiai canoinoaaiiy o?aaeeoe?eieo e?ea?nueeeo
cania?a, aiia caeeoa?oueny iaei??th c iaea?eueo ?iciianthaeaeaieo i?e/ei
na?oeaai-noaeeiii? caoai?thaaiiino? e nia?oiino? a onueiio na?o? (Yusuf
G., Lonn E. M., 1994; Pfeffer M. A., 1996).

Iniaeeaa oaaaa aeine?aeiee?a i?eae?ey?oueny aea/aiith
aeaeo?iea?ae?io?c?ieia?/ii? aeoeaiino? aeey aecia/aiiy /?oeeo e?eoa???a
ooieoe?iiaeueiiai noaio i?iea?aea caniaaie AEA — aenieiai i?aeneeaiiy,
niaeo?aeueii-oei/aniaiai ea?ooaaiiy, ioe?iee aa??aaaeueiino? na?oeaaiai
?eoio, ui ia? aaaeeeaa cia/aiiy ye aeey ?icoi?iiy iaoiaaiaoe/ieo
iaoai?ci?a, oae ? aeey ?ic?iaee ?aoe?iiaeueieo oeyo?a oa?iaeieia?/ii?
ei?aeoe?? o?ii?/ii? iaaeinoaoiino? e?iaiia?ao (Beny J. L., Brunet P. C.,
1994; El–Sherif N., 1995).

Ii?ooaiiy, ui aeyaeythoueny i?e aeaeo?iea?ae?io?c?ieia?/ieo
aeine?aeaeaiiyo, a?ae?a?athoue i?ia?aeio ?ieue aeey ?icoi?iiy iaoiaaiaco
OIE. A ca’yceo c oeei aeine?aeaeaiiy aieeao e?ea?nueeeo i?aia?ao?a ia
aeaeo?e/io aeoeai?noue i?iea?aea aoaea ni?eyoe eiiieaeniiio ?icoi?iith
iaoiaaiaoe/ieo iaoai?ci?a OIE ? aaeineiiaeaiith oa?iaeieia?/ii?
ei?aeoe?? iaaeinoaoiino? e?iaiia?ao.

Aaaeeeaei a ioe?ioe? ee?i?/iiai e i?iaiinoe/iiai cia/aiiy OIE ?
?icoe?aii? iiaeeeainoae ?? aeeoa?aioe?eiaaii? oa?ai?? ? aea/aiiy
oa?aeoa?o aeenooieoe?? e?aiai oeoii/ea (EO). Iiiyooy aeenooieoe?? EO
anioe?thaaeinue ?ai?o eeoa c? ci?iith nei?ioeeai? ooieoe?? i?iea?aea oa
cieaeaiiyi o?aeoe?? aeeeaeo. Anoaiiaeaii, ui na?oeaaa iaaeinoaoi?noue
iaeaea caaaeaee aeeth/a? eiiiiiaio ae?anoie?/ii? aeenooieoe??, a o
aeayeeo oai?eo (a?ia?o?io?/iith ea?ae?ii?iiao??th, ia ?oai?/io oai?iao
na?oey (?ON) c a?oa??aeueiith a?ia?oii??th) aiia ? iniiaiith
ooieoe?iiaeueiith iaoieia??th. A ca’yceo c oeei aeioe?eueii aeyaeyoe
ae?anoie?/io aeenooieoe?th aeey ?? iaaeeeaiaioicii? ei?aeoe??.

Canoinoaaiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo (AIO)
aeoiaeeoue ia aaaeo/a i?noea a oa?ai?? oai?eo o?ii?/iith iaaeinoaoi?noth
e?iaiia?ao. Ii ?acoeueoaoai aaaaoioeaio?iaeo aeine?aeaeaiue (SOLVD,
1991, 1992; SAVE, 1992; CONSENSUS, 1987 oa ?i.) oe? i?aia?aoe ni?eythoue
ciaioaiith caaaeueii? eaoaeueiino? oa /anoioe nia?o? a?ae o?ii?/ii?
iaaeinoaoiino? e?iaiia?ao, a oiio /ene? ? o oai?eo, ye? ia?aianee
?ioa?eo i?iea?aea (AIRE, 1993; TRACE, 1995 oa ?i.).

?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo ciaeoee oe?iea
canoinoaaiiy a e?eoaaii? o?ii?/ii? iaaeinoaoiino? e?iaiia?ao, ine?eueee
aiie ?aaoeththoue ii?ooai? iae?iaoii?aeuei? aca?iia?aeiineie a
i?aai?ci?, neiiaoiaae?aiaeiao, ?ai?i-aia?ioaicei-aeueaeinoa?iiiao
nenoaie oa eae?e?a?i-e?i?iiao nenoaio, a oaeiae ? ia?eoa?e/ieie
aaciaeeeaoaoi?aie ci?oaiiai oeio.

Ne?ae a?aecia/eoe, ui iaoiaee i?iaiico oa aoaeoeaiino? oa?ai?? OIE, ye?
canoiniaothoueny a oaia?aoi?e /an, e?euee?nii ia a?aoiaothoue
aeaeo?io?c?ieia?/i? aeanoeaino? i?iea?aea. Ia ?ic?iaeai? aeeoa?aioe?ei?
i?aeoiaee aei oa?iaeioa?ai?? OIE ?ia?a?oi?aie AIO ia i?aenoaa?
aeo?aeiiai noaio aeaeo?io?c?ieia?/ii? aeoeaiino? i?iea?aea.

Aeyaeaiiy aoaeo?a oa?ai?? ?ia?a?oi?aie AIO i?e OIE ia
aeaeo?io?c?ieia?/iee noai i?iea?aea oa ia?aiao?e iae?iaoii?aeueii?
aeoeaiino? i?aaenoaaeythoue iaoeiaee oa i?aeoe/iee ?ioa?an a
ea?ae?ieia??, ui ? noaei i?aaeiaoii aeaiiai aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aea?aiee iai?yiie aeine?aeaeaiue iia’ycaiee c iaoeiaith ae?yeuei?noth oa
aoiaeeoue aei oaiaoe/iiai ieaio ?inoeoooo oa?ai?? AII Oe?a?ie, ye
o?aaiaio iaoeiai-aeine?aeieoeueei? ?iaioe: “Aea/eoe iaoiaaiaoe/ia
cia/aiiy oa ?ic?iaeoe e?eoa??? ae?aaiinoeee oa i?iaiicoaaiiy na?oeaai?
iaaeinoaoiino? o oai?eo ia ?oai?/io oai?iao na?oey oa ?ic?iaeoe e
cai?iiiioaaoe iaoiaaiaoe/i? noaie ?? iaaeeeaiaioiciiai e?eoaaiiy ?c
canoinoaaiiyi ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo oa
aioaaii?no?a ?aoeaioi??a aia?ioaiceio ??” – ?aa.? 0197U008307.

Iaoa ? caaea/? aeine?aeaeaiiy.

Iaoith ?iaioe ? i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy OIE ia i?aenoaa?
ioe?iee aeaeo?io?c?ieia?/ieo aeanoeainoae i?iea?aea oa
ea?ae?iaaiiaeeiai?ee, aca?iica’yceo ?o c iae?iaoii?aeueieie iaoai?ciaie
a i?ioean? oa?ai?? ?ia?a?oi?aie AIO.

Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaea/?:

Ioe?ieoe nenoie?/io oa ae?anoie?/io ooieoe?? i?iea?aea niiniaaie
niaeo?aeueiiai aiae?co aeaeo?io?c?ieia?/ieo iieaciee?a ?
aeiiea?aoiea?ae?ia?ao?? o in?a a?oie eiio?iey e o oai?eo ia OIE.

Noi?ioethaaoe ocaaaeueiai? ?ioaa?aeuei? aeaeo?io?c?ieia?/i? e?eoa???
?aiiuei? ae?aaiinoeee OIE.

I?iaanoe eiiieaenio ioe?ieo aieeao ?ia?a?oi??a AIO ia
aeaeo?io?c?ieia?/i? aeanoeaino? i?iea?aea oa ae?anoie?/io ooieoe?th
e?aiai oeoii/ea.

Aecia/eoe aca?iica’ycie i?ae iieacieeaie aeaeo?io?c?ieia?/ii? oa
iae?iaoii?aeueii? (aacii?anei, aiaeioae?i-1, IIOO) aeoeaiino? a
aeeiai?oe? e?eoaaiiy ?ia?a?oi?aie AIO oai?eo ia OIE.

Aecia/eoe aoaeoeai?noue e?eoaaiiy OIE ?ia?a?oi?aie AIO a
?iaeea?aeoaeueii i?ae?a?aieo aeicao c o?aooaaiiyi anoaiiaeaieo
ae?aaiinoe/ieo e?eoa???a.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

Aeyaeaii caeaaei?noue ae?anoie?/ii? oa nenoie?/ii? aeenooieoe??
i?iea?aea e?aiai oeoii/ea ii aeaiei niaeo?aeueiiai aiae?co
aeaeo?io?c?ieia?/ieo aeine?aeaeaiue oa aeiiea?aoiea?ae?ia?ao?? a?ae
oyaeeino? ee?i?/iiai ia?aa?ao OIE.

?ic?iaeaii ?ioaa?aeuei? ae?aaiinoe/i? e?eoa??? ia iniia? ocaaaeueiaii?
ii?iiaaii? niaeo?aeueii? iiooaeiino?.

Cai?iiiiiaaia iiaeaeue ioe?iee iieaciee?a niaeo?aeueii?
aeiiea?-aoiea?ae?ia?ao?? a ii?i? oa i?e OIE ??ciiai nooiaiy oyaeeino?.

Anoaiiaeaii iniaeeaino? ci?ie iieaciee?a o?aini?o?aeueiiai e?iaia?ao oa
aoiea?ae?ia?ao?? a aeeiai?oe? e?eoaaiiy OIE ?ia?a?oi?aie AIO o
c?noaaeaii? c aoaeoeai?noth aacenii? oa?ai??.

Aia?oa aecia/aii ca aeiiiiiaith niaeo?aeueiiai aiae?co e?eoa???
?iaeea?aeoaeueii? ioe?iee i?iaiico oa aoaeoeaiino? oa?ai?? OIE
?ia?a?oi?aie AIO.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

Anoaiiaeaia aaaeeeaa i?aeoe/ia ?ieue aecia/aiiy ae?anoie?/ii?
aeenooieoe?? oa aeaeo?io?c?ieia?/ieo aeanoeainoae i?iea?aea o oai?eo ia
OIE, ?oi?e aca?iica’ycie c iae?iaoii?aeueieie ia?aiao?aie, ui aeicaiey?
i?aeaeueoe ye?noue ?aiiuei? ae?aaiinoeee.

?ic?iaeai? iaoiaeeee e e?eoa??? aeicaieythoue ee?i?oeenoo ia’?eoecoaaoe
i?iaiic oa aoaeoeai?noue e?eoaaiiy.

Cai?iiiiiaai? ae?aaiinoe/i? e?eoa??? ioe?iee noaio i?iea?aea iiaeooue
aooe ?aeiiaiaeiaai? aeey i?aeoe/iiai aeei?enoaiiy a eiii’thoa?ieo
ea?ae?ieia?/ieo nenoaiao.

?acoeueoaoe i?iaaaeaiiai aeine?aeaeaiiy ai?iaaaeaeai? o i?aeoe/io ?iaioo
ee?i?ee ?inoeoooo oa?ai?? AII Oe?a?ie, e?eoaaeueieo caeeaae?a
I?i?noa?noaa Aioo??oi?o Ni?aa (IAN) Oe?a?ie: iie?ee?i?ee oi?aae?iiy IAN
i.Oa?eiaa, iie?ee?i?ee oa aini?oaeth oi?aae?iiy IAN i. Aeiiaoeueea oa
iaeano?, iie?ee?i?ee oa aini?oaeth oi?aae?iiy IAN i. ?aaii-O?aie?anueea
oa iaeano?; e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a IIC Oe?a?ie:
Eoi’yinueei? oeaio?aeueii? ?aeiiii? e?ea?i? Oa?e?anueei? iaeano? oa
Aeia?ii?euenueei? oeaio?aeueii? ?aeiiii? e?ea?i? Aeiiaoeueei? iaeano? .

Iniaenoee aianie caeiaoaa/a.

Naiino?eii cae?enithaaea ianoaaeaiiy oa i?aea?? oai?eo ia OIE c
aeei?enoaiiyi ee?i?ei-?ino?oiaioaeueieo oa eaai?aoi?ieo iaoiae?a,
i?aea?? ae?oa?aioe?eiaaii? oa?ai?? oa eiio?ieue ca aoaeoeai?noth
e?eoaaiiy.

Canoiniaoaaea oae? iaoiaee aeine?aeaeaiiy oai?eo:
aeiiea?aoiea?ae?ia?ao?th, aecia/aiiy eiioeaio?aoe?? a ieaci? e?ia?
aacii?aneio, IIOO, aiaeioaeiio-1 ?aaeiiiioiieiai/iei iaoiaeii,
aecia/aiiy iiaeeaiaeoaeueio? oa?aiaaoe/ii aoaeoeaii? aeice i?aia?aoo
eeiiiei-iioiieiai/iei iaoiaeii O-aeoeaiiai ?icaoeiooai?aiiy oa
aecia/aiiy ocaaaeueiaieo ?ioaa?aeueieo aeaeo?ioiciieiai/ieo ia?aiao?ia
iiiea?aea ca aeiiiiiaith eiii’thoa?ii? aeaeo?iea?aeiia?aoi? oa iioa.

Aaoi? iniaenoi aecia/aea iaoo oa ieaioaaea caaaeaiiy aeineiaeaeaiiy,
i?iaiaeeea aiaeic oa iaoaiaoe/io ia?iaeo io?eiaieo ?acoeueoaoia c
aeei?enoaiiyi aeaeo?iiii-ia/enethaaeueii? oaoi?ee, ioi?iethaaea
aeena?oaoe?eio ?iaioo.

Ai?iaaoe?y ?iaioe.

Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ? iaaiai?thaaeenue ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo ?inoeoooo oa?ai?? AII Oe?a?ie
(1996-1998), ?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? iieiaeeo
a/aieo oa oao?aoe?a “No/ani? ooiaeaiaioaeuei? oa i?eeeaaei? i?iaeaie a
ee?i?oe? aioo??oi?o caoai?thaaiue” (Oa?e?a, 1997), ia Ia?oiio
i?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a oa iieiaeeo a/aieo
(Oa?iii?eue, 1997), Neiiic?oi? naeoe?? NIAe i?aeia?iaeiiai oiaa?enoaa ii
aea/aiith na?oey (Iineaa, 1997). Aieiai? iieiaeaiiy aeena?oaoe?? aoee
i?aaenoaaeai? ia Anana?oiueiio eiia?an? iaaee/ii? o?ceee oa a?iiaaee/ii?
?iaeaia??? (??i aea AEaiae?i, 1993), ia 4 I?aeia?iaei?e eiioa?aioe?? ii
ia?iaaceai?e ea?ae?ieia?? (E?i?, 1993), ia XX Eiia?an? ?a?iiaenueeiai
oiaa?enoaa ea?ae?ieia?a (A?aeaiue, 1998).

?acoeueoaoe ?iaioe “Niaeo?aeueiee aiae?c AEA a ioe?ioe?
ooieoe?iiaeueiiai noaio na?oey” a?aecia/ai? Iaaeaeeth “Ca e?auo
nooaeaionueeo iaoeiao ?iaioo 1993 ?ieo”. Aaoi? oe??? ?iaioe noaea
eao?aaoii i?ai?? Iaoe?iiaeueii? Aeaaeai?? Iaoe aeey nooaeaio?a aeueo
o/aiaeo caeeaae?a 1993 ?ieo.

Ioae?eaoe??.

Ii oai? aeena?oaoe?eii? ?iaioe iioae?eiaaii 14 ?ia?o, c yeeo 7 – o
iaoeiaeo aeo?iaeao, 6 – aac ni?aaaoi??a. Ca iaoa??aeaie aeena?oaoe??
io?eiaii iaoaio ia aeiao?ae “Niin?a ioe?iee ooieoe?iiaeueiiai noaio
na?oey” ? 2067417.

No?oeoo?a oa ianya aeena?oaoe??.

Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 190 noi??ieao iaoeiiieniiai oaenoo e
neeaaea?oueny c anooio, 3 ?icae?e?a, ui aeeth/athoue iaeyae e?oa?aoo?e,
aeani? aeine?aeaeaiiy, iaaiai?aiiy io?eiaieo ?acoeueoao?a, a oaeiae
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae.
A?ae?ia?ao?/iee iieaae/ee i?noeoue 352 aeaea?aea, c ieo 65 — ia
oe?a?inuee?e oa ?in?enuee?e iiaao, 282 ca?oa?aeieo aeaea?ae. ?iaioa
?ethno?iaaia 13 ?enoieaie (ianyaii 13 noi?.) oa 15 oaaeeoeyie (ianyaii
10 noi?.).

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy.

Ia’?eoii aeine?aeaeaiiy aoee 118 oai?eo c o?ii?/iith iaaeinoaoi?noth
e?iaiia?ao, ye? ciaoiaeeeenue ia ianoaaeaii? oa e?eoaaii? a ee?i?oe?
?inoeoooo oa?ai?? AII Oe?a?ie. Na?aae ieo aoei 98 /ieia?e?a (83%) ? 20
ae?iie (17%) o a?oe? a?ae 33 aei 74 ?ie?a. Na?aaei?e a?e ianoaaeaieo
noaiiaea 54,2( 4,8 ?ieo. Eiio?ieueio a?oio neeaee 26 i?aeoe/ii caei?iaeo
in?a o a?oe? a?ae 25 aei 52 ?ie?a (na?aaei?e a?e 40(7 ?ie?a).

Ca eeaneo?eaoe??th Iueth-Ei?enueei? anioe?aoe?? na?oey (NYHA) iciaee
iaaeinoaoiino? e?iaiia?ao I ooieoe?iiaeueiiai eeano (OE) aecia/aeeny o
28 oai?eo (23%), II — o 67 (57%), III — o 23 oai?eo (20%). O?eaae?noue
OIE o 76 (64%) oai?eo aoea aei 5 ?ie?a, a o 42 (36%) — iiiaae 5 ?ie?a.

OIE ?icaeeanue aiane?aeie ?ON o 38 oai?eo (32%), ?ON c iino?ioa?eoiei
ea?ae?ineea?icii (aeaai?noue inoaiiueiai aino?iai ?ioa?eoa i?iea?aea —
ia iaio iaeiiai ?ieo) o 37 oai?eo (32%), o 13 oai?eo (11%) aiane?aeie
a?ia?oii?/ii? oai?iae, o 24 (20%) — a?ia?oii?/ii? oai?iae ia oii? ?ON,
aeeeaoaoe?eii? ea?ae?ii?iiao?? o 6 oai?eo (5%).

I?e aiae?c? /eiiee?a ?eceeo OIE iaea?eueo /anoi cono??/aeeny:
a?ia?e?i?aeai?? (18%), o?eaaeee noaae ?ON (42%), ia?aianai? ?ioa?eoe
i?iea?aea (31%), a oiio /ene? ii?aeiaiiy aeae?eueeio /eiiee?a. Na?aae
oe?aeeeaeo cae/ie iaea?eueo /anoi cono??/aeeny iae?iiy — 61 ethaeeia
(52%), caaaeueiee noaae iae?iiy aa??thaaa o iaaeao a?ae 7 aei 41 ?ieo
(21(2 ?ieo), na?aaeiy e?euee?noue aeiaeaieo ca aeiao neaa?ao neeaea
12,3(4,0. Aaeeaaiiy aeeiaiey a aiaiiac? aeeooy i?inoaaeoaaeinue o 81
(69%) oai?iai. Iaee??iiyi (?iaeaen Eaoea > 30,0) no?aaeaeaei 13 /ieia?e
(11%), oeoe?iaei ae?aaaoii 4 (3%) oai?eo, iaei?ooiiee niin?a aeeooy aaee
59 (50%) oai?eo.

A iaoa aeine?aeaeaiiy ia aeeth/aeeny oai?? c o?ii?/iith iaaeinoaoi?noth
e?iaiia?ao iiiaae ??? OE, c noi?ia?aeieie caoai?thaaiiyie, ui iiaee a
nooo?ai aieeiooe ia i?iaiic ? aeiaaaee niaoe?aeueiiai iaaeeeaiaioiciiai
e?eoaaiiy: c ae?aaeaieie ii?ooaiiyie ?eoio, ?acenoaioiith a?oa??aeueiith
a?ia?oaic??th, oeoe?iaei ae?aaaoii aaaeeiai ia?aa?ao, aeoeaiith oacith
?aaiaoecio.

An? oai?? aoee ?aoaeueii ee?i?/ii ianoaaeai?. Ooieoe?iiaeueiee noai
i?iea?aea ioe?ithaaee niiniaii niaeo?aeueiiai aiae?co aia?aaoe/iiai
??aiy i?iea?aea ia ?ioa?aaeao aeaiiey?ecaoe?? oa ?aiiey?ecaoe?? (Iaea
E.O. e ni?aaao., 1996) c ?a?no?aoe??th ii?oieia?/ieo aeaiaio?a AEA, c
ianooiiei aeae?eaiiyi ?ioa?aae?a P-Q+QRS oa ST-T+T-P, aecia/aiiyi
ae?aaiinoe/iiai e?eoa??th (Aee). I?e cia/aii? Aee, ??aiei aai iaioei
0,4, a oaeiae ??aiei aai a?eueoei 0,6 i??eothoue i?i ii?ooaiiy
ooieoe?iiaeueiiai noaio i?iea?aea. Aeiaeaoeiai aeae?eai? ?ioa?aaee AEA
aeei?enoiaoaaee aeey aecia/aiiy e?eoa??th aia?aaoe/iiai ??aiy i?iea?aea,
oiaoi iioaioe?eii? ae??caeaoiino? na?oey. ?ioa?aae P-Q+QRS
oa?aeoa?eco? o?eaae?noue caoaeaeaiiy ia?aaena?aeue oa oeoii/e?a
na?oey ia noaae?? aeaiiey?ecaoe??, ?ioa?aae ST-T+T-P —
o?eaae?noue ?icneaaeaiiy i?iea?aea ia?aaena?aeue, oeoii/e?a ia noaae??
?aiiey?ecaoe??.

Aaiiaeeiai?/i? ia?aiao?e ioe?ithaaee iaoiaeii aoiea?ae?ia?ao?? ia
aia?ao? “Aloka” SSD-280 (ssiii?y) ca caaaeueiii?eeiyoith iaoiaeeeith.
Aecia/aee ianooii? iieacieee: e?ioeaaee ae?anoie?/iee ?ici?? (EAe?),
e?ioeaaee ae?anoie?/iee ia(?i (EAeI), e?ioeaaee nenoie?/iee ?ici??
(EN?), e?ioeaaee nenoie?/iee ia(?i (ENI), oaeaee?noue oee?eoey?iiai
oei?i/aiiy aieieii i?iea?aea (OOeO), nooi?iue oei?i/aiiy
ia?aaeiuei-caaeiueiai ?ici??o e?aiai oeoii/ea (NO), o?aeoe?y aeeeaeo
(OA), oaea?iee ia(?i (OI).

Aeiiea?aoiea?ae?ia?ao?th ia aia?ao? SIM 5000 Plus (“Biomedica”, ?oae?y)
i?iaiaeeee aeey aea/aiiy noaio ae?anoie?/ii? aeenooieoe?? e?aiai
oeoii/ea oeyoii ioe?iee ia?aiao??a ae?anoie?/iiai o?aini?o?aeueiiai
e?iaia?ao (AeOIE). Aecia/aee iaeneiaeueio oaeaee?noue e?iaia?ao
?aiiueiai ae?anoie?/iiai iaiiaiaiiy EO (I1) oa iaeneiaeueio oaeaee?noue
e?iaia?ao a nenoieo ia?aaena?aey (I2), aeiiea?ianueeee ?iaeaen I1/I2. Ca
niaeo?ii aeiiea?ianueeeo /anoio AeOIE aecia/aee ?ioaa?aeueio oaeaee?noue
?aiiueiai ae?anoie?/iiai iaiiaiaiiy (E) oa ?ioaa?aeueio oaeaee?noue
i?ciueiai ae?anoie?/iiai iaiiaiaiiy (A), eiao?oe??io A/A.

?iaeaen ?iaeea?aeoaeueii? /ooeeaino? aei e?ea?nueeiai i?aia?aoo
(aiaeai?eeo) aecia/aee ee?i?ei-?ioiieia?/iei iaoiaeii aeoeaiiai
?icaoeiooai?aiiy O-e?ioioeeo?a c a?eo?ioeeoaie aa?aia, ianooiiei
ia/eneaiiyi oa?aiaaoe/ii aoaeoeaii? aeiaiai? aeice (Ia?aaea?ee A.A.,
Caineia A.I., Ai?/eiaa I.A., 1995).

Ai?no aiaeioae?ia-1, ia?aaena?aeiueiai iao??eo?aoe/iiai oaeoi?a (IIOO),
aacii?aneia aeyaeyee ?aae?i?ioiieia?/iei iaoiaeii ca aeiiiiiaith
noaiaea?oieo iaai??a o??ie DRG (NOA).

An? ?acoeueoaoe aeine?aeaeaiiy aoee ia?iaeai? ca aeiiiiiaith iaoiaeo
aa??aoe?eii? noaoenoeee ia ia?niiaeueiiio eiii’thoa?? c ia/eneaiiyi
na?aaeiuei? aaee/eie I, na?aaeiueieaaae?aoe/iiai a?aeoeeaiiy (,
na?aaeiuei? iiieeee na?aaeiuei? aaee/eie m, e?eoa??th a??ia?aeiino? t,
cia/aiiy a??ia?aeiino? ?. A?aei?iiino? i?ae iieacieeaie, ui
ii??aiththoueny, c?ciaaaeenue a??ia?aeieie, yeui cia/aiiy ?iia??iino?
aoei a?eueoei aai ??aii 95% (?<0, 05). ?acoeueoaoe aeine?aeaeaiue. Anoaiiaeaii, ui aeei?enoaiee a ?iaio? aia?aaoe/iee i?aeo?ae i?e niaeo?aeueiiio aiae?c? AEA aeicaieea cai?iiiioaaoe aoaeoeaiee aeai?eoi ia?iaee o aeaeyae? ii?iiaaii? ocaaaeueiaii? niaeo?aeueii? iiooaeiino? ii?oieia?/ieo aeaiaio?a aeaio ?ioa?aae?a: P-Q+QRS oa ST-O+T-P. Iaoaiaoe/ia nooue niaeo?aeueiiai aiae?co uiaei AEA i?aaenoaaey?oueny ne?aeoth/ei /eiii: aaaaea?ii AEA ooieoe??th /ano E (t+tz), yea iiaoi?th?oueny eiaeiee ea?ae?ioeeee, o?eaae?noth tz. A?aeiii, ui neeaaeio ia??iaee/io ooieoe?th (aei yei? a?aeiineoueny AEA) iiaeia ?iceeanoe ia i?ino? ia??iaee/i? ooieoe?? (aa?iii?ee) ? i?aaenoaaeoe o aeaeyae? ?yaeo Oo?(?. I?aaenoaaeaiiy niaeo?aeueii? iiooaeiino? o a?aeiinieo iaeeieoeyo aeaei iiaeeea?noue c?noaaeoe ??ci? AEA. Cia/aiiy iiooaeiino? 2-? aa?iii?ee iaeiaio? o iaoee?io?a aac ii?ooaiue ooieoe?iiaeueiiai noaio (0,03-0,037), a?eueo? o oai?eo ia ?ON (0,051-0,061) ? iaea?eueo? i?e a?ia?oii?/i?e oai?ia? (0,142 - 0,147). Iiae?aia ni?aa?aeiioaiiy iiooaeiinoae, aea c iaioeie cia/aiiyie niinoa??aaee ia 1 oa 6-e aa?iii?eao. Ioaea, ?ioi?iaoe?y i?i iiooaei?noue, ui i?noeoueny a 1, 2 oa 6-e aa?iii?eao, aeicaiey? noaeeoe ia o?eueee i?i a?aenooi?noue aai iayai?noue ii?ooaiue ooieoe?iiaeueiiai noaio na?oey, aea e aeicaiey? i?iaiaeeoe aeeoa?aioe?eio ae?aaiinoeeo. Aeyaeaia aeniea ?ioi?iaoeai?noue cia/aiue iiooaeiino? 2-? aa?iii?ee ?ioa?aaeo P-Q+QRS, ui aeicaieeei noi?ioethaaoe aeaeo?io?c?ieia?/iee niaeo?aeueiee e?eoa??e (AONE). Io?eiai? nooo?ai iae? cia/aiiy iiooaeiinoae ia aenieeo aa?iii?eao (/anoioao), iniaeeai ia ?ioa?aae? ST-O+T-P, ye o caei?iaeo, oae ? o oai?eo iieacaee, ui i?ioeane aeaiiey?ecaoe?? oa iniaeeai ?aiiey?ecaoe?? c aia?aaoe/ii? oi/ee ci?o ? iecueei/anoioieie i?ioeanaie. Aiae?c AEA ia aac? cai?iiiiiaaieo aia?aaoe/ieo niaeo?aeueieo oa?aeoa?enoee aeicaiey? iaea?aeaoe aaaeeeao aeiaeaoeiao e?euee?nio ae?aaiinoe/io ?ioi?iaoe?th i?i ?iciianthaeaeaiiy caoaeaeaiiy e aeaeo?io?c?ieia?/i? aeanoeaino? i?iea?aea, ni?ey? i?aeaeuaiith yeino? ia'?eoeaii? ioe?iee ooieoe?iiaeueiiai noaio na?oey oa aeicaiey? a/anii aeyaeyoe ?aii? noaae?? ii?ooaiiy na?oeaai? ae?yeueiino?. I?e aeine?aeaeaii? nenoie?/ii? ooieoe?? i?iea?aea aoee cieaeai? OA, NO, OOeO (?<0,05); ca?eueoai? ENI, EAeI (?<0,05). I?e aeine?aeaeaii? ae?anoie?/ii? ooieoe?? a?aecia/aii cieaeaiiy oaeaeeino? ?aiiueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea, eiao?oe??io?a I1/I2 oa A/A, oiaoi i?aeaeuaia “aei?noe?noue” i?iea?aea e?aiai oeoii/ea. Iecuee? aaee/eie A/A /ano?o cono??/aee o oai?eo c a?ia?o?io??th i?iea?aea e?aiai oeoii/ea, i?e/iio nooi?iue cieaeaiiy ni?aa?aeiioaiiy A/A ia caeaaeaa a?ae aaee/eie iane i?iea?aea. O oai?eo ia OIE ?? OE ae?anoie?/io aeenooieoe?th e?aiai oeoii/ea ia??aeei niinoa??aaee e ca a?aenooi?noth ci?i ia?aiao??a oeaio?aeueii? aaiiaeeiai?ee. Io?eiai? ?acoeueoaoe na?ae/aoue i?i aca?iica'ycie oyaeeino? OIE oa i??e ae?anoie?/ii? aeenooieoe?? EO. C ia?inoaiiyi oyaeeino? OIE o oai?eo niinoa??aaee a??ia?aeia cieaeaiiy iaeneiaeueii? oaeaeeino? ?aiiueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea (I1), ?iaeaeno I1/I2, eiao?oe??ioo A/A. Aaaeeeai a?aecia/eoe, ui iaeaea o 18% oai?eo OIE II ooieoe?iiaeueiiai eeano ae?anoie?/io aeenooieoe?th EO niinoa??aaee ca a?aenooi?noth ci?i iieaciee?a oeaio?aeueii? aaiiaeeiai?ee, ui a?aeiia?aea? aeaiei e?oa?aoo?e (Konstam M. A., et al., 1994; Sutton M. S. J., Pfeffer M. A., et al., 1996). O ?aieao aeaii? ?iaioe aoei i?iaiae?ciaaii aca?iica'ycie i?ae iieacieeaie AeOIE, ui oa?aeoa?ecothoue ae?anoie?/io ooieoe?th EO, oa a?eii iaoe??io?a oa in?a a?oie eiio?ieth. Ca ?acoeueoaoaie aeyaeaii ianooiio caeiiii??i?noue: c? ca?eueoaiiyi a?eo ianoaaeaieo niinoa??aaee nooo?aa cieaeaiiy iaeneiaeueii? oaeaeeino? iioieo aeno?iai iaiiaiaiiy, cieaeaiiy na?aaeiueiai oiia?eueiaiiy iioieo aeno?iai iaiiaiaiiy EO, ciaioaiiy ni?aa?aeiioaiiy I1/I2 oa A/A. Oea iiaeia iiynieoe ?icaeoeii niieo/iioeaieiiiai o?a?ica no?oeoo? na?oey i?e noa??ii?, a oiio /ene? o caei?iaeo in?a. O i?iaaaeaiiio aeine?aeaeaii? aea/aii aieea aacenii? oa?ai?? oa ?ia?a?oi??a AIO o 109 oai?eo OIE II-III OE (NYHA). A aeeiai?oe? e?eoaaiiy ?ia?a?oi?ii AIO aiaeai?eeii ia oii? aacenii? oa?ai?? ianoaaeaii 63 oai?eo (48 /ieia?e?a oa 15 ae?iie; na?aaei?e a?e 54,3(6,1 ?ieo). I?e oeueiio OIE II OE ae?aaiinoiaaii o 36 oai?eo, III OE - o 27. C iaoith ii??aiyiiy aoaeoeaiino? ?ia?a?oi?a AIO 46 oai?ei aoei i?ecia/aii eeoa aacenio oa?ai?th OIE. Ii??aithaaeuei? a?oie ia iaee cia/ieo a?aei?iiinoae ii nooiaith oyaeeino? OIE, noao?, a?eo, ??aith a?oa??aeueiiai oeneo. E?eoaaiiy i?iaiaeeee oeyoii ia?i?aeueiiai i?eeiio i?aia?aoo a iaaeao anoaiiaeaieo ?aciaeo ? aeiaiaeo aeic, ?iaeea?aeoaeueii i?ae?a?aieo eiaeiiio ianoaaeaiiiio c o?aooaaiiyi ee?i?ei-?ioiieia?/iiai ?iaeaeno ?iaeea?aeoaeueii? /ooeeaino? aei i?aia?aoo. Oae aiaeai?ee canoiniaoaaee a aeic? 2,5-20 ia/aeiao a 1 aai 2 i?eeiia. Eo?n e?eoaaiiy neeaaeaa 4 oeaei?. Aiane?aeie i?iaaaeaiiai eo?no e?eoaaiiy c aeei?enoaiiyi aiaeai?eea (a?oia ?) I OE aecia/aany o 34 oai?eo, II OE - o 24, III OE - o 5 oai?eo. Ia?ao?ae aei a?eueo e?auiai OE niinoa??aaee o 56 (88,9%) oai?eo. A a?oi? oai?eo, ui iaea?aeoaaee o?eueee aacenio oa?ai?th (a?oia II), ia?ao?ae a a?eueo e?auee OE a?aeaoany o 37 (80,4%) oai?eo. I?e aea/aii? aioo??oiueina?oeaai? aaiiaeeiai?ee iaoiaeii e?euee?nii? aoiea?ae?ia?ao?? niinoa??aaee oaiaeaioe?th aei cieaeaiiy EAe? ia 3,8% ? EN? ia 2,9% (?>0,05). Ia?aeaeueii c ieie ciaiooaaeenue ? ia(?ii?
iieacieee EAeI ia 5,6% (?>0,05) ? ENI ia 12,4% (?<0,05), ui ia(?eoea?co? iie?ioaiiy oiia ooieoe?thaaiiy i?iea?aea i?e canoinoaaii? ?ia?a?oi??a AIO. A?aecia/aii oaeiae iaa??ia?aeia ca?eueoaiiy OA, NO ? OOeO. I?ae aieeaii aiaeai?eea (oaae.1) a?aeaoeiny a??ia?aeia ca?eueoaiiy ni?aa?aeiioaiiy A/A, ui na?ae/eoue i?i iie?ioaiiy ae?anoie?/ii? ooieoe?? i?iea?aea e?aiai oeoii/ea oai?eo ia OIE aiane?aeie eo?niaiai e?eoaaiiy, a oaeiae nooo?aa ca?eueoaiiy aeiiea?ianueeiai ?iaeaeno I1/I2, iaeneiaeueii? oaeaeeino? ?aiiueiai ae?anoie?/iiai iaiiaiaiiy EO (I1) (oai?eo c ?ano?eeoeaiei oeiii iioieo ia aoei, i?o?aeueia ?aao?a?oaoe?y aoea a?aenooiy). Oaaeeoey 1 - Aieea aiaeai?eea ia iieacieee o?aini?o?aeueiiai e?iaia?ao (M±m) o oai?eo ia OIE aac i?o?aeueii? ?aao?a?oaoe?? Ooieoe?iiaeueiee eean (NYHA) Iieaciee Eiio?ieue-ia a?oia II (n=36) III (n=27) (n=26) Aei e?eoaaiiy I?ney e?eoaaiiy Aei e?eoaaiiy I?ney e?eoaaiiy 1 2 3 4 5 6 1 2 3 4 5 6 Iaeneiaeueia oaeaee?noue ?aiiueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea (I1), ni/n 79,44±3,00 62,3±2,31 68,21±1,30 59,17±6,29 64,94±1,35 Iaeneiaeueia oaeaee?noue e?iaia?ao a nenoieo ia?aaena?aey (I2), ni/n 68,34±3,81 71,40±5,1 74,40±4,1* 83,34±6,75 90,2±5,24** Aeiiea?ianueeee ?iaeaen I1/I2, one. iae. 1,19±0,07 0,87±0,09 0.91±0,09* 0,71±0,10 0,72±0,10** Eiao?oe??io A/A, one. iae. 1,65±0,08 0,95±0,12 1,56±0,19* 0,86±0,11 1,16±0,17** I?ei?oea. A??ia?aei?noue a?aei?iiino? iieaciee?a aei oa i?ney e?eoaaiiy: *- p <0, 05; ** - p < 0,01 Anoaiiaeaii aieea aiaeai?eea ia niaeo?aeuei? oa?aeoa?enoeee AEA o oai?eo, ui aeaco?, c iaeiiai aieo, ia iiaeeeaino? niiniao niaeo?aeueii? AEA a ioe?ioe? oa?aiaaoe/ii? ae??, c ?ioiai aieo, ia iiaeeea?noue i?iaiicoaaiiy aoaeoeaiino? aea?aiiai caniao e?eoaaiiy c aeiiiiiaith niaeo?aeueieo aeaeo?io?c?ieia?/ieo oa?aeoa?enoee. Ioe?ieo ?ioi?iaoeaiino? AONE, eiai /ooeea?noue a aeeiai?oe? e?eoaaiiy aecia/aee ca aeiiiiiaith a?aeiiniiai iieacieea ( , ui yaey? niaith a?aeiioaiiy o a?aenioeao ??ciino? cia/aiue AONE ia?aae oa i?ney e?eoaaiiy aei eiai cia/aiiy aei e?eoaaiiy. Ia i?aenoaa? oeueiai ( aeei?enoiaoaaee a yeino? i?iaiinoe/iiai iieacieea ioe?iee aoaeoeaiino? e?eoaaiiy, ui aeaeii c aeaieo oaae. 2. Oaaeeoey 2 - I?iaiinoe/ia ioe?iea (iieaciee aoaeoeaiino? e?eoaaiiy aiaeai?eeii a %) ia i?eeeaae? aea??ee a?oie oai?eo ia OIE ??-??? OE ii ae?aaiinoe/iiio aeaeo?io?c?ieia?/iiio niaeo?aeueiiio e?eoa??th Oai?ee Cia/aiiy e?eoa???a Eiae Ee?i?/iee ae?aaiic Noai AONE Aei e?eoaaiiy 0,122 10 ?ON. Noaa?eueia noaiiea?ae?y ?? OE. A?ia?oii?/ia oai?iaa ?? no. OIE ?? OE I?ney e?eoaaiiy 0,066 Iieaciee aoaeoeaiino?,% ( =45,9 Aei e?eoaaiiy 0,057 21 ?ON.Iino?ioa?eoiee ea?ae?ineea?ic. OIE ?? OE I?ney e?eoaaiiy 0,048 Iieaciee aoaeoeaiino?,% ( =15,8 Aei e?eoaaiiy 0,059 25 ?ON. Noaa?eueia noaiiea?ae?y ?? OE. OIE ?? OE I?ney e?eoaaiiy 0,034 Iieaciee aoaeoeaiino?,% ( =42,4 Aei e?eoaaiiy 0,17 31 ?ON. I?ia?aneaia noaiiea?ae?y iai?oae. OIE ??? OE I?ney e?eoaaiiy 0,127 Iieaciee aoaeoeaiino?,% ( =25,3 Oaeei /eiii, ca aeiiiiiaith iieacieea aoaeoeaiino? e?eoaaiiy ( a?aee?eaa?oueny iiaeeea?noue niinoa?aaeaiiy ca aeeiai?eith e?eoaaiiy aiaeai?eeii, i?iaiicoaaoe eiai aoaeoeai?noue, aeei?enoiaoaaoe ye aeni?an-i?iao aieeao e?ea?nueeiai i?aia?aoo. I?iaeaiiino?iaaia a ?iaio? cia/ia iie?auaiiy i?ney 4-oeaeiaai? oa?ai?? aiaeai?eeii niaeo?aeueieo iieaciee?a AEA iiaea aooe iia'ycaia c iie?ioaiiyi aeaeo?io?c?ieia?/ieo aeanoeainoae i?iea?aea aiane?aeie a?aeiiaeaiiy ei?iia?ii? ia?ooc?? oa ooieoe?e ?oai?ciaaiiai (o oai?eo ia ?ON), aea aeeoo?caeaoiiai i?iea?aea. Iaea?aeai? ?acoeueoaoe na?ae/aoue i?i oa, ui i?ia?anoaaiiy oyaeeino? ee?i?/ieo i?iya?a OIE noi?iaiaeaeo?oueny ii?ooaiiyi iaoai?ci?a iae?iaoii?aeiii? ?aaoeyoe??. ??aaiue aiaeioae?ia-1 aeyaeee aeua o a?eueoino? oai?eo ia OIE i?e ii??aiyii? c eiio?ieueiith a?oiith. Ai?no aiaeioae?ia-1 ca?eueooaaany ii i??? ia?iuoaaiiy oyaeeino? OIE. I?aeaeuaiiy ieaciiaiai ??aiy aiaeioae?ia-1 iaaea? oiiae aei ?icaeoeo aaciniacia, o?iiaiooai?aiiy ? i?ioean?a i?ie?oa?aoe??, ui aaaeooue aei ii?ooaiiy ooieoe?? na?oey. Aiae?c eiioeaio?aoe?? IIOO o ianoaaeaieo oai?eo aeicaieea aeyaeoe, ui ii i??? i?ia?anoaaiiy oyaeeino? ee?i?/ieo i?iya?a OIE a?aei?/a?oueny ca?eueoaiiy ??aiy IIOO a ieaci? oai?eo, ui iiaeia ?icaeyaeaoe ye aaaeeeaee eiiiainaoi?iee iaoai?ci o iaoiaaiac? OIE. Aiane?aeie i?iaaaeaiiai ei?aeyoe?eiiai aiae?co i?ae ai?noii IIOO ? oyaee?noth OIE aeyaeaii aenieiaeinoia??iee iiceoeaiee na?aaeiuei? neee (r=+0,59; p<0,01) ca'ycie i?ae oeeie ia?aiao?aie. Aeyaeaii ei?aeyoe?eiee ca'ycie i?ae ??aiai IIOO ? aaee/eiith NO (r=+0,54; p<0,01). Iiceoeaia ei?aeyoe?y ??aiy IIOO ? NO, ui a?aeaeaa? ianinio ooieoe?th e?aiai oeoii/ea, na?ae/eoue i?i caeaaei?noue ai?noo IIOO a?ae i?aeneeaiiy ?iaioe eiiiainaoi?iiai iaoai?cio O?aiea-Noa?e?iaa o a?aeiia?aeiino? c i?aeaeuaiiyi ia?aaeiaaaioaaeaiiy. Ai?no IIOO ei?aethaaa c aeiiea?ianueeei eiao?oe??ioii A/A (r=-0,41; p<0,05) ni?aa?aeiioaiiy ?ioaa?ae?a oaeaeeinoae ?aiiueiai ? i?ciueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea. I?ae ae??th e?eoaaiiy aiaeai?eeii (oaae.3) a?aeaoeiny nooo?aa cieaeaiiy ieaciiai? eiioeaio?aoe?? aacii?aneia ia 24% (p<0,01), aiaeioae?ia-1 ia 21,7% (p<0,05) ? IIOO ia 27,3% (p<0,01). Ia oii? aacenii? oa?ai?? a??ia?aeii ciaioeany eeoa ??aaiue IIOO ia 22,3% (p<0, 01). Cieaeaiiy aeoeaiino? aiaeioae?ia-1 ? aacii?aneia i?e oa?ai?? ?ia?a?oi?ii AIO ni?ey? aeeeaoaoe?? e?iaiiinieo noaeei, oeyoii /iai iie?ioo?oueny e?iaiia?a ? ciaioo?oueny ia?eoa?e/iee noaeeiiee ii?? oa a?oa??aeueiee oene. Oaaeeoey 3 - Aeeiai?ea iieaciee?a iae?iaoii?aeueii? ?aaoeyoe?? o oai?eo ia OIE a a?oiao oa?ai?? (M±m) Iieaciee Aiaeai?ee +aacenia oa?ai?y n=63 Aacenia oa?ai?y n=46 Aei e?eoaaiiy I?ney e?eoaaiiy Aei e?eoaaiiy I?ney e?eoaaiiy aacii?anei, ia/e aiaeioae?i-1, ia/e IIOO, iiieue/e 7,32±0,54 17,26±1,36 18,37±1,32 5,56±0,21** 13,51±1,24* 13,36±1,05** 7,28±0,89 16,85±1,23 18,69±1,63 6,01±0,52 14,36±1,14 14,52±0,89* I?ei?oea. A??ia?aei?noue a?aei?iiinoae iieaciee?a aei oa i?ney e?eoaaiiy: MACROBUTTON TrVara?aei?iiinoae|??cieoeue|?ica?aeiinoae * - p<0, 05; ** - p<0, 01 Aeyaeaii ianooii? a??ia?aei? ei?aeyoe?? (?en.1) i?ae ci?iaie ia?aiao??a iae?iaoii?aeueii? aeoeaiino? ? iieacieeaie aaiiaeeiai?ee a i?ioean? e?eoaaiiy ?ia?a?oi?aie AIO: i?ae aeeiai?eith aacii?aneia ? ENI (r=+0,59; p<0,01), aacii?aneia ? NO (r=+0,42; ?<0,05); aiaeioae?ia-1 ? OA (r=-0,47; ?<0,05), IIOO ? EAeI (r=+0,61; ?<0,01), IIOO ? OA (r=-0,36; ?<0,05), IIOO ? NO (r=+0,32; ?<0,05). Aecia/aii ei?aeyoe?ei? ca'ycee i?ae aeeiai?eith IIOO ? ci?iaie iieaciee?a ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea i?e e?eoaaii? aiaeai?eeii: i?ae ci?iaie IIOO ? ni?aa?aeiioaiiy A/A (r=-0,32; p<0,05) ?ioaa?ae?a oaeaeeinoae ?aiiueiai ? i?ciueiai iaiiaiaiiy e?aiai oeoii/ea. C oeueiai ne?aeo?, ui ii?ooaiiy ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea ni?ey? noeioeyoe?? nae?aoe?? IIOO, oiae? ye ii?iae?caoe?y ai?noo IIOO i?ae ae??th aiaeai?eea anioe?thaaeany c iie?ioaiiyi ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea. ?iaeea?aeoaeueiee aiae?c aeyaea, ui iaea?eueoo aoaeoeai?noue ?ia?a?oi??a AIO a?aei?/aee o oai?eo c a?eueo aenieei aeo?aeiei nooiaiai ci?i iieaciee?a iae?iaoii?aeueii? ?aaoeyoe??. Aiae?c aca?iica'yceo ci?i iieaciee?a iae?iaoii?aeueii? ?aaoeyoe?? oa AONE aeyaea ianooii? a??ia?aei? ei?aeyoe?ei? ca'ycee: i?ae aeeiai?eith IIOO e AONE, aacii?aneia e AONE (r=+0,39; p<0,05), aiaeioae?ia-1 e AONE (r=+0,42; p<0,05). ?en 1. Anioe?aoe?? i?ae ia?aiao?aie iae?iaoii?aeueii? aeoeaiino? oa aaiiaeeiai?ee a i?ioean? e?eoaaiiy aiaeai?eeii oai?eo ia OIE Iiceoeaiee na?aaeiuei? neee ei?aeyoe?eiee ca'ycie Iiceoeaiee neaaeee ei?aeyoe?eiee ca'ycie Iaaaoeaiee neaaeee ei?aeyoe?eiee ca'ycie Iaea?aeai? ?acoeueoaoe na?ae/aoue i?i niaoeeo?/i?noue ci?i iieaciee?a iae?iaoii?aeueii? aeoeaiino? (aacii?aneia, aiaeioae?ia-1, IIOO) ii a?aeiioaiith aei oa?aeoa?enoee niaeo?aeueii? iiooaeiino? ia ??cieo /anoioao ia ?ioa?aaeao aeaiiey?ecaoe?? oa ?aiiey?ecaoe?? ? aeaiiino?othoue iaaio caeaaei?noue iaoai?ci?a iae?iaoii?aeueii? ?aaoeyoe?? c aeaeo?io?c?ieia?/iei noaiii i?iea?aea a oiae? e?eoaaiiy ?ia?a?oi?aie AIO. AENIIAEE Cai?iiiiiaai? aia?aaoe/i? niaeo?aeuei? oa?aeoa?enoeee aeicaieythoue ia ?ioa?aaeao aeaiiey?ecaoe?? oa ?aiiey?ecaoe?? noi?ioethaaoe ?ioaa?aeuei? e?eoa???, ui ioe?iththoue ooieoe?iiaeueiee noai i?iea?aea. Aeniea ?ioi?iaoeai?noue cia/aiue niaeo?aeueii? iiooaeiino? aea? iiaeeea?noue aecia/eoe ?iaeea?aeoaeuei? iieacieee aoaeoeaiino? e?eoaaiiy. E?euee?ni? oa?aeoa?enoeee aeaeo?io?c?ieia?/ii? aeoeaiino? i?iea?aea ? aeiiea?aoiea?ae?ia?ao?/i? ia?aiao?e o oai?eo ia OIE ei?aeththoue c iae?iaoii?aeueieie iieacieeaie (ieaciiaei ??aiai aacii?aneia, aiaeioae?ia-1, IIOO). Aoaeo aieeao ?ia?a?oi??a AIO ia aeaeo?io?c?ieia?/i? ia?aiao?e i?iea?aea aecia/aee ?o ae??th ia iae?iaoii?aeuei? iieacieee. Oanooaaiiy ?ia?a?oi??a AIO iaoiaeii aeiiea?aoiea?ae?ia?ao?? oeyoii ioe?iee ae?anoie?/iiai o?aini?o?aeueiiai e?iaia?ao ni?ey? iioeiaeueiiio i?ecia/aiith e?ea?nueeeo i?aia?ao?a ? i?io?eaeoeoe? iaaeinoaoiino? e?iaiia?ao. Aoaeoeai?noue i?ecia/aiiy ?ia?a?oi??a AIO c o?aooaaiiyi ee?i?ei-?ioiieia?/iiai ?iaeaeno ?iaeea?aeoaeueii? /ooeeaino? aei i?aia?aoo o oai?eo ia OIE, ui noi?iaiaeaeo?oueny cia/iei iioaioe?thaaiiyi ae?? aacenii? oa?ai??, iieyaa? a neia?a?ci? ?o aieeao ia ia?aiao?e aaiiaeeiai?ee, aeaeo?e/ii? oa iae?iaoii?aeueii? aeoeaiino?. I?AEOE*I? ?AEIIAIAeAOe?? C iaoith i?aeaeuaiiy yeino? ia'?eoeaii? ioe?iee ooieoe?iiaeueiiai noaio i?iea?aea ia ?aii?o noaae?yo OIE oa aoaeoeaiino? oa?ai?? aeioe?eueii canoiniaoaaoe aiae?c AEA ia aac? niaeo?aeueieo oa?aeoa?enoee. Aeey aeeoa?aioe?eiaaiiai e?eoaaiiy oai?eo ia OIE ?ia?a?oi?aie AIO ?aoe?iiaeueii aeei?enoiaoaaoe ?ic?iaeai? ?ioaa?aeuei? aeaeo?io?c?ieia?/i? niaeo?aeuei? ae?aaiinoe/i? e?eoa??? oa i?iaiinoe/iee e?eoa??e ioe?iee aoaeoeaiino? e?eoaaiiy (( ). Ia ei?enoue ni?eyoeeaiai i?iaiico oa?ai?? OIE ?ia?a?oi?aie AIO ? aeai?, ye? na?ae/aoue i?i iie?ioaiiy ia?aiao??a ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea. Ioe?ieo ia?aiao??a o?aini?o?aeueiiai e?iaia?ao iaiao?aeii i?iaiaeeoe c iaoith ?aiiuei? ae?aaiinoeee iaaeinoaoiino? e?iaiia?ao. A eiiieaen oa?iaeioa?aiaaoe/ieo cania?a i?e e?eoaaii? OIE ?aeiiaiaeo?oueny aeeth/aoe ?ia?a?oi? AIO (aiaeai?ee) a ?iaeea?aeoaeueii i?ae?a?aieo oa?aiaaoe/ii aoaeoeaieo aeicao i?ae eiio?ieai aeaeo?io?c?ieia?/ieo ia?aiao??a. NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? Eo?uea N.C. Aeeyiea yiaeai?eea ia nenoiee/aneoth e aeeanoiee/aneoth ooieoeee eaaiai aeaeoaei/ea i?e o?iie/aneie na?aea/iie iaaeinoaoi/iinoe // Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.-1998.-?4.-N.24-25. Eo?uea N.C, Ei?ae A.I., Ieeieaiei A.ss. Eciaiaiey o?iaiy i?aaena?aeiiai iao?eeo?aoe/aneiai oaeoi?a iiae aeeyieai yiaeai?eea o aieueiuo n o?iie/aneie na?aea/iie iaaeinoaoi/iinoueth // Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.-1998.-?7-8.-N.65-67. Ei?ae A.I., Eo?uea N.C. Aeeyiea eiaeaeoi?ia aiaeioaiceii?a-a?auathuaai oa?iaioa ia iae?iaoii?aeueiua iaoaieciu i?e o?iie/aneie na?aea/iie iaaeinoaoi/iinoe //Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.- 1998.- ?9.-N.63-64. Ei?ae A.I., Eo?uea N.C. Iniaaiiinoe aeeyiey eiaeaeoi?a aiaeioaicei-i?aa?auathuaai oa?iaioa aa?eei?eea ia iae?iaoii?aeueiua iaoaieciu i?e o?iie/aneie iaaeinoaoi/iinoe e?iaiia?auaiey // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.-1998.-?17.-N.37-39. Eo?uea N.C. Cia/aiea niaeo?aeueiie aeiiiea?yoiea?aeeia?aoee a aeeaa-iinoeea e ioeaiea yooaeoeaiinoe ea/aiey yiaeai?eeii aieueiuo n o?iie/aneie iaaeinoaoi/iinoueth e?iaiia?auaiey // Iaoa??aee XIV C’?caeo oa?aiaao?a Oe?a?ie.-Ee?a, 1998.-N.188-191. Eo?uea N.C., Ei?ae A.I., Ieeieaiei A.ss. Ei??aeoeey aa?eei?eeii ieaciaiiiai o?iaiy i?aaena?aeiiai iao?eeo?aoe/aneiai oaeoi?a o aieueiuo o?iie/aneie iaaeinoaoi/iinoueth e?iaiia?auaiey // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.-1998.-?19.-N.63-66. Eo?uea N.C. Aiciiaeiinoe niaeo?aeueiiai aiaeeca YEA aeey ioeaiee ooieoeeiiaeueiiai ninoiyiey na?aeoea // A?a/aaiay i?aeoeea. - 1998. -N4.- N.5-14. Eo?uea N.C. Niaeo?aeueiue aiaeec YEA a ioeaiea ooieoeeiiaeueiiai ninoiyiey na?aeoea // Aanoiee i?iaeai nia?aiaiiie iaaeeoeeiu.-1994.-Aui.2.-N.88-94. Eo?uea N.C. I?eiaiaiea niaeo?aeueiiai aiaeeca YEA aeey ioeaiee ooieoeeiiaeueiiai ninoiyiey na?aeoea // Eeeie/aneay oa?iaeieiaey e oa?aiey: Na. iao/i. o?oaeia OAIO. - Oa?ueeia, 1994.-N.99-105. Eo?uea N.C. Yeaeo?ioeceieiae/aneea e?eoa?ee ioeaiee ooieoeeiiaeueiiai ninoiyiey ieiea?aea o aieueiuo n na?aea/ii-ninoaeenouie caaieaaaieyie // Nia?aiaiiua i?iaeaiu eeeieee aioo?aiieo aieaciae: Na. iao/i. o?oaeia e 120-eaoeth eaoaae?u ainieoaeueiie oa?aiee OAIO. - Oa?ueeia, 1997.-N.151-158. Eo?uea N.C., Eo?uea C.ss. Niaeo?aeueiue aiaeec YEA // Iaaeeoeeia naaiaeiy e caao?a: Na. iao/i. o?oaeia OAIO. - Oa?ueeia, 1996.- N.33-35. Eo?uea N.C., Ei?ae A.I., Ieeieaiei A.ss. Iioeiecaoeey ea/aiey o?iie-/aneie iaaeinoaoi/iinoe e?iaiia?auaiey // Iaaeeoeeia naaiaeiy e caao?a: Na. iao/i. o?oaeia OAIO. - Oa?ueeia, 1998. - Aui.3. - N.30-31. Iao. 2067417 ?O, IEE A 61 A 5/0452. Niinia ioeaiee ooieoeeiiaeueiiai ninoiyiey na?aeoea / Iaeay E.O., Oeuaaieia A.E., Eo?uea N.C., Eo?uea C.ss.; Oe?aeineee IEE oa?aiee (Oe?aeia).-N5062487/14; Cayae.18.09.92; Oioae.10.10.96; Athe.N 26.-3n. L.T. Malaya, A.N. Korzh, L.B. Balkovaya, S.Z.Lourye, A.V. Zhmuro. The effect of ACE inhibition on endothelin-1 and insulin in patients with angina pectoris // 20th Congress of the European Society of Cardiology.-Vienna, 1998.- European Heart Journal.-1998.-Vol.19.-P.301. Eo?(? N.C. Aeaeo?io?c?ieia?/i? oa aaiiaeeiai?/i? aoaeoe ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo o oai?eo ia o?ii?/io iaaeinoaoi?noue e?iaiia?ao. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 – ea?ae?ieia?y. – Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1998. Aeena?oaoe?y i?enay/aia aea/aiith aeaeo?io?c?ieia?/ieo aeanoeainoae i?iea?aea oa ea?ae?iaaiiaeeiai?ee, aca?iica'yceo ?o c iae?iaoii?aeueieie iaoai?ciaie i?e e?eoaaii? oai?eo ia OIE ?ia?a?oi?aie AIO. A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue cai?iiiiiaaii aia?aaoe/i? niaeo?aeuei? oa?aeoa?enoeee, ui aeicaieeee noi?ioethaaoe ?ioaa?aeuei? e?eoa??? ia ?ioa?aaeao aeaiiey?ecaoe?? oa ?aiiey?ecaoe?? aeey ioe?iee ooieoe?iiaeueiiai noaio i?iea?aea e aoaeoeaiino? e?eoaaiiy. Anoaiiaeaii, ui aoaeo aieeao ?ia?a?oi??a AIO ia aeaeo?io?c?ieia?/i? ia?aiao?e i?iea?aea iia'ycaiee c ?o ae??th ia iae?iaoii?aeuei? iieacieee. Aeiaaaeaii, ui aoaeoeai?noue ?ia?a?oi??a AIO, i?ecia/aieo c o?aooaaiiyi ?iaeaeno ?iaeea?aeoaeueii? /ooeeaino? aei e?ea?nueeiai i?aia?aoo, i?e OIE, ui noi?iaiaeaeo?oueny cia/iei iioaioe?thaaiiyi ae?? aacenii? oa?ai??, iieyaa? a neia?a?ci? ?o aieeao ia iieacieee ae?anoie?/ii? ooieoe?? e?aiai oeoii/ea, aeaeo?e/ii? oa iae?iaoii?aeueii? (IIOO, aacii?anei, aiaeioae?i-1) aeoeaiino?. Eeth/ia? neiaa: ae?anoie?/iee o?aini?o?aeueiee e?iaia?a, ae?anoie?/ia aeenooieoe?y, aiaeioae?i-1, IIOO, aacii?anei, niaeo?aeueiee aiae?c AEA, ?ioaa?aeuei? aeaeo?io?c?ieia?/i? e?eoa???, o?ii?/ia iaaeinoaoi?noue e?iaiia?ao, ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioo. Eo?uea N.C. Yeaeo?ioeceieiae/aneea e aaiiaeeiaie/aneea yooaeou eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa i?e o?iie/aneie iaaeinoaoi/iinoe e?iaiia?auaiey. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 – ea?aeeieiaey. Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1998 a. Aeenna?oaoeey iinayuaia eco/aieth yeaeo?ioeceieiae/aneeo naienoa ieiea?aea e ea?aeeiaaiiaeeiaieee, acaeiinayce eo n iae?iaoii?aeueiuie iaoaieciaie i?e ea/aiee aieueiuo n o?iie/aneie iaaeinoaoi/iinoueth e?iaiia?auaiey eiaeaeoi?aie AIO. Ia?ooaiey, auyaeyaiua i?e yeaeo?iea?aeeioeceieiae/aneeo enneaaeiaaieyo, ea?atho aaaeioth ?ieue aeey iiieiaiey iaoiaaiaca OIE. A nayce n yoei enneaaeiaaiey aeeyiey eaea?noaaiiuo i?aia?aoia ia yeaeo?e/aneoth aeoeaiinoue ieiea?aea niinianoaotho eiiieaeniiio iiieiaieth iaoiaaiaoe/aneeo iaoaieciia OIE e niaa?oainoaiaaieth oa?iaeieiae/aneie ei??aeoeee iaaeinoaoi/iinoe e?iaiia?auaiey. Oeaeueth ?aaiou yaeeinue iiauoaiea yooaeoeaiinoe ea/aiey OIE ia iniiaaiee ioeaiee yeaeo?ioeceieiae/aneeo naienoa ieiea?aea e ea?aeeiaaiiaeeiaieee, acaeiinayce eo n iae?iaoii?aeueiuie iaoaieciaie a i?ioeanna oa?aiee eiaeaeoi?aie AIO. A ?aaioa ioeaiaiu nenoiee/aneay e aeeanoiee/aneay ooieoeee ieiea?aea iaoiaeaie niaeo?aeueiiai aiaeeca yeaeo?ioeceieiae/aneeo iieacaoaeae e aeiiiea?yoiea?aeeia?aoee a ii?ia e o aieueiuo OIE; noi?ioee?iaaiu iaiauaiiua eioaa?aeueiua yeaeo?ioeceieiae/aneea e?eoa?ee ?aiiae aeeaaiinoeee OIE; i?iaaaeaia eiiieaeniay ioeaiea aeeyiey eiaeaeoi?ia AIO ia yeaeo?ioeceieiae/aneea naienoaa ieiea?aea e aeeanoiee/aneoth ooieoeeth eaaiai aeaeoaei/ea; ii?aaeaeaia acaeiinaycue iaaeaeo iieacaoaeyie yeaeo?ioeceieiae/aneie e iae?iaoii?aeueiie (aacii?annei, yiaeioaeei-1, IIOO) aeoeaiinoe a aeeiaieea ea/aiey eiaeaeoi?aie AIO aieueiuo OIE; oaeaea ii?aaeaeaia yooaeoeaiinoue ea/aiey OIE eiaeaeoi?aie AIO a eiaeeaeaeoaeueii iiaeia?aiiuo aeicao n o/aoii onoaiiaeaiiuo aeeaaiinoe/aneeo e?eoa?eaa. Iauaeoii enneaaeiaaiey auee 118 aieueiuo n OIE, iaoiaeeaoeony ia ianeaaeiaaiee e ea/aiee a eeeieea Einoeoooa oa?aiee AII Oe?aeiu. N?aaee aieueiuo auei 98 ioae/ei (83%) e 20 aeaiuei (17%) a aic?anoa io 33 aei 74 eao. N?aaeiee aic?ano ianeaaeiaaiiuo ninoaaee 54,2±4,8 aiaea. Ii eeanneoeeaoeee Iueth-Ei?eneie annioeeaoeee na?aeoea (NYHA) i?eciaee iaaeinoaoi/iinoe e?iaiia?auaiey I ooieoeeiiaeueiiai eeanna ii?aaeaeyeenue o 28 aieueiuo (23%), II - o 67 aieueiuo (57%), III - o 23 aieueiuo (20%). Aeeeoaeueiinoue OIE o 76 (64%) aieueiuo auea aei 5 eao, a o 42 (36%) aieueiuo - nauoa 5 eao. Eiio?ieueioth a?oiio ninoaaeee 26 i?aeoe/anee caei?iauo eeoe a aic?anoa io 25 aei 52 eao (n?aaeiee aic?ano 40±7 eao). Onoaiiaeaii, /oi iinea i?iaaaeaiiiai eo?na ea/aiey n eniieueciaaieai yiaeai?eea (a?oiia ?) I OE ii?aaeaeai o 34 aieueiuo, II OE - o 24 aieueiuo, III OE - o 5 aieueiuo. Ia?aoiae e aieaa ieceiio OE iaaethaeaeny o 56 (88,9%) aieueiuo. A a?oiia aieueiuo, iieo/aaoeo oieueei aacenioth oa?aieth (a?oiia II), ia?aoiae a aieaa eaaeee OE i?iecioae o 37 (80,4%) aieueiuo. A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee i?aaeeiaeaiu yia?aaoe/aneea niaeo?aeueiua oa?aeoa?enoeee, iicaieeaoea noi?ioee?iaaoue eioaa?aeueiua e?eoa?ee ia eioa?aaeao aeaiiey?ecaoeee e ?aiiey?ecaoeee aeey ioeaiee ooieoeeiiaeueiiai ninoiyiey ieiea?aea e yooaeoeaiinoe ea/aiey. I?e eco/aiee aioo?ena?aea/iie aaiiaeeiaieee iaoiaeii eiee/anoaaiiie yoiea?aeeia?aoee iaaethaeaeanue oaiaeaioeey e nieaeaieth EAe? e EN?. Ia?aeeaeueii n ieie oiaiueoathony e iauaiiua iieacaoaee EAeI e ENI, /oi iauaeoeaece?oao oeo/oaiea oneiaee ooieoeeiie?iaaiey ieiea?aea i?e i?eiaiaiee eiaeaeoi?ia AIO. Ioia/aii oaeaea iaaeinoiaa?iia oaaee/aiea OA, NO e NOeO. Iiae aeeyieai yiaeai?eea i?iecioei aeinoiaa?iia oaaee/aiea niioiioaiey A/A, /oi naeaeaoaeuenoaoao ia oeo/oaiee aeeanoiee/aneie ooieoeee ieiea?aea eaaiai aeaeoaei/ea aieueiuo OIE a ?acoeueoaoa eo?niaiai ea/aiey, a oaeaea nouanoaaiiia oaaee/aiea aeiiiea?ianeiai eiaeaena I1/I2, iaeneiaeueiie nei?inoe ?aiiaai aeeanoiee/aneiai iaiieiaiey EAE (I1) (aieueiuo n ?ano?eeoeaiui oeiii iioiea ia auei, ieo?aeueiay ?aao?aeoaoeey ionoonoaiaaea). Iiae aeaenoaeai ea/aiey yiaeai?eeii i?iecioei nouanoaaiiia nieaeaiea ieaciaiiie eiioeaio?aoeee aacii?anneia, yiaeioaeeia-1 e IIOO. Ia oiia aaceniie oa?aiee aeinoiaa?ii oiaiueoeeny eeoue o?iaaiue IIOO. Nieaeaiea aeoeaiinoe yiaeioaeeia-1 e aacii?anneia i?e oa?aiee eiaeaeoi?ii AIO niinianoaoao aeeeaoaoeee e?iaaiiniuo ninoaeia, iin?aaenoaii /aai oeo/oaaony e?iaioie e oiaiueoaaony ia?eoa?e/aneia ninoaeenoia nii?ioeaeaiea e a?oa?eaeueiia aeaaeaiea. Eiaeeaeaeoaeueiue aiaeec auyaee, /oi iaeaieueoay yooaeoeaiinoue eiaeaeoi?ia AIO ioia/aeanue o aieueiuo n aieaa aunieie enoiaeiie noaiaiueth eciaiaiee iieacaoaeae iae?iaoii?aeueiie ?aaoeyoeee. Iieo/aiiua ?acoeueoaou naeaeaoaeuenoaotho i niaoeeoe/iinoe eciaiaiee iieacaoaeae iae?iaoii?aeueiie aeoeaiinoe (aacii?anneia, yiaeioaeeia-1, IIOO) ii ioiioaieth e oa?aeoa?enoeeai niaeo?aeueiie iiuiinoe ia ?aciuo /anoioao ia eioa?aaeao aeaiiey?ecaoeee e ?aiiey?ecaoeee, e aeaiiino?e?otho ii?aaeaeaiioth caaeneiinoue iaoaieciia iae?iaoii?aeueiie ?aaoeyoeee e yeaeo?ioeceieiae/aneiai ninoiyiey ieiea?aea a oiaea ea/aiey eiaeaeoi?aie AIO. Aeieacaii, /oi yooaeoeaiinoue eiaeaeoi?ia AIO, iacia/aiiuo n o/aoii eiaeaena eiaeeaeaeoaeueiie /oanoaeoaeueiinoe e eaea?noaaiiiio i?aia?aoo, nii?iaiaeaethuayny cia/eoaeueiui iioaioee?iaaieai aeaenoaey aaceniie oa?aiee OIE, caeeth/aaony a neia?aecia eo aeeyiey ia iieacaoaee aeeanoiee/aneie ooieoeee eaaiai aeaeoaei/ea, yeaeo?e/aneie e iae?iaoii?aeueiie (IIOO, aacii?annei, yiaeioaeei-1) aeoeaiinoe. Eeth/aaua neiaa: aeeanoiee/aneee o?ainieo?aeueiue e?iaioie, aeeanoiee/aneay aeenooieoeey, yiaeioaeei-1, IIOO, aacii?annei, niaeo?aeueiue aiaeec YEA, eioaa?aeueiua yeaeo?ioeceieiae/aneea e?eoa?ee, o?iie/aneay iaaeinoaoi/iinoue e?iaiia?auaiey, eiaeaeoi?u aiaeioaiceii?aa?auathuaai oa?iaioa. Lurye S.Z. Electrophysiologic and Hemodynamic Effects of the Angiotensin Converting Enzyme Inhibitors in Patients with Chronic Heart Failure.- Manuscript. Thesis for candidate of medical science degree on speciality 14.01.11 - cardiology. - Kharkiv State Medical University, Kharkiv, 1998. The dissertation is dedicated to studying of electrophysiologic properties of myocardium and cardiohemodynamics, their intercommunication with neurohumoral mechanisms during treatment of patients with chronic heart failure (CHF) with angiotensin converting enzyme (ACE) inhibitors. As a result of the experiments carried out we suggest the power spectral characteristics which make it possible to formulate the integral criteria on intervals of depolarization and repolarization for evaluation of the functional state of myocardium and of treatment efficiency. It was established that the effect of ACE inhibitors in patients with CHF on electrophysiologic properties of myocardium is connected with their action on neurohumoral factors. It was proved that the efficiency of ACE inhibitors in patients with CHF, prescribed with account of the parameters of individual sensivity to a medicine in CHF, is accompanied by a considerable augment of the basic therapy effect and consists in joint of their influence on the parameters of the left ventricle diastolic function, and electrical and neurohumoral (atrial natriuretic peptide, vasopressin, endothelin-1) activity. Key words: diastolic transmitral circulation, diastolic dysfunction, endothelin-1, atrial natriuretic peptide, vasopressin, spectral analysis of electrocardiogram, integral electrophysiological criteria, chronic heart failure, angiotensin converting enzyme inhibitors. NEI?I*AIIss A - ?ioaa?ae oaeaeeino? ia??iaeo i?ciueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea AIO - aia?ioaiceiia?aoai?thth/ee oa?iaio Aee - ae?aaiinoe/iee e?eoa??e AeOIE - ae?anoie?/iee o?aini?o?aeueiee e?iaia?a A - ?ioaa?ae oaeaeeino? ia??iaeo ?aiiueiai ae?anoie?/iiai iaiiaiaiiy e?aiai oeoii/ea AEA - aeaeo?iea?ae?ia?aia AONE - aeaeo?io?c?ieia?/iee niaeo?aeueiee e?eoa??e ?ON - ?oai?/ia oai?iaa na?oey EAeI - e?ioeaaee ae?anoie?/iee ia(?i EAe? - e?ioeaaee ae?anoie?/iee ?ici?? ENI - e?ioeaaee nenoie?/iee ia(?i EN? - e?ioeaaee nenoie?/iee ?ici?? EO - e?aee oeoii/ae I1 - iaeneiaeueia oaeaee?noue ?aiiueiai ae?anoie?/iiai iaiiaiaiiy EO I2 - iaeneiaeueia oaeaee?noue e?iaia?ao a nenoieo ia?aaena?aey IIOO - ia?aaena?aeiee iao??eo?aoe/iee oaeoi? NO - nooi?iue oei?i/aiiy ia?aaeiuei-caaeiueiai ?ici??o EO OI - oaea?iee ia(?i OA - o?aeoe?y aeeeaeo OE - ooieoe?iiaeueiee eean OIE - o?ii?/ia iaaeinoaoi?noue e?iaiia?ao OOeO - oaeaee?noue oee?eoey?iiai oei?i/aiiy aieieii i?iea?aea IIOO Aiaeioae?i - 1 Aacii?anei NO OA EAeI ENI

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