OE?A?INUeEEE IAOEIAEE A?A??I?*IEE OeAIO?

Nethna?aiei Aaiia Aieiaeeie??aia

OAeE [614.777+614.71]:615.9:612.111

AENI?AN-IOe?IEA O?I?*IEO OAEOI??A AIAeIIAI OA IIA?O?ssIIAI NA?AAeIAEUA
IA I?AeNOAA? A?EO?IOeEOA?II? IIAeAE?

14.02.01 -a?a??ia

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a 1999

Aeena?oaoe?y ? ?oeiienii.

?iaioa aeeiiaia a Iaoeiai-aeine?aeiiio ?inoeooo? caaaeueii? ?
eiioiaeueii? a?a??ie ?i. I.I.Ia?ca?aa Oe?a?inueeiai iaoeiaiai
a?a??i?/iiai oeaio?o I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie.

IAOEIAEE EA??AIEE:

aeieoi? a?ieia?/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Aioiiiiia
Ieoaeei TH??eiae/, Iaoeiai-aeine?aeiee ?inoeooo caaaeueii? oa
eiioiaeueii? a?a??ie ?i. I.I.Ia?c??aa I?i?noa?noaa ioi?iie caei?ia’y
Oe?a?ie, caa?aeoaa/ eaai?aoi???

IO?Oe?EI? IIIIAIOE:

aeieoi? a?ieia?/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Oiiaoaanueea
Ethaeieea Aiaoie??aia, Iaoeiai-aeine?aeiee ?inoeooo caaaeueii? oa
eiioiaeueii? a?a??ie ?i. I.I.Ia?c??aa I?i?noa?noaa ioi?iie caei?ia’y
Oe?a?ie, i?ia?aeiee iaoeiaee ni?a?ia?oiee

aeieoi? iaaee/ieo iaoe, i?ioani? Noaiaiaiei Aaiiaae?e Iaianiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. 0.0. Aiaiiieueoey I?i?noa?noaa
ioi?iie caei?ia’y Oe?a?ie, i?ioani? eaoaae?e i?iiaaeaaoeee a?a??ie,
a?enueeiai? oa ?aae?aoe?eii? a?a??ie

I?IA?AeIA ONOAIIAA: ?inoeooo aeia?a??ie ? oieneeieia?? ?iai?
E.?.Iaaeaaaey, a?aeae?e a?a??ie iie?ia??a oa oiene/ieo a?aeoiae?a ?
eaai?aoi??y iooaaaiaco, I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie, i.Ee?a

Caoeno a?aeaoaeaoueny »14» o?aaiy 1999 ?ieo i 12 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.604.01 a Oe?a?inueeiio iaoeiaiio
a?a??i?/iiio oeaio?? ca aae?anith: 253660, i. Ee?a-94, aoe. Iiioae?aiea,
50

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Oe?a?inueeiai
iaoeiaiai a?a??i?/iiai oeaio?o, i. Ee?a, aoe. Iiioae?aiea, 50

Aaoi?aoa?ao ?ic?neaiee »13» ea?oiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee
A.TH.Naeaciueia

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie

Na?aae aieiaieo i?iaeai XX noie?ooy iaea?eueo cia/iith ? aeieia?/ia, yea
iia’ycaia c? ci?iith na?aaeiaeua oa oiia aeeooy ethaeeie (Na?aethe A.I.,
1996). ?acoeueoaoe a?a??i?/ieo oa aeieia?/ieo niinoa?aaeaiue ca noaiii
caa?oaeiaiiy aieiaieo ia’?eo?a iaaeieeoiueiai na?aaeiaeua (iia?o?y,
aiaee oa a?oioo) a Oe?a?i? na?ae/aoue, ui neooaoe?y iiaea aooe
eaae?o?eiaaia ye aeno?aiaeueia (Eoiae??a TH.?., Aii/a?oe ?.A. oa ?i.,
1995). No/ani? i?aeoiaee aei a?a??i?/ii? ioe?iee yeino? na?aaeiaeua
aeiaaathoue aeeth/aiiy aei nenoaie a?a??i?/iiai eiio?ieth aaeeei?
e?eueeino? ??ciiiai?oieo a?i?iaeeeaoi??a, aeei?enoaiiy a?ioanooaaiiy.

C?inoaiiy aio?iiiaaiiiai iaaaioaaeaiiy ia aeaea?aea aiaeiiinoa/aiiy,
iecueea aoaeoeai?noue ?iaioe aiaeii?ia?aeieo i/enieo nii?oae, /anoi
iacaaeia?eueiee noai nenoai ?iciiae?eo aiaee iaoiiaeththoue
iaiao?aei?noue iiooeo aeueoa?iaoeaieo ??oaiue caaacia/aiiy ianaeaiiy
iaoi? e?a?ie ye?niith aiaeith oa ?? a?a??i?/ii? ioe?iee ia ??cieo aoaiao
aiaeii?aeaioiaee (Aieiuaiei I.E„ I?ieiiia A.A. e ae?., 1991; I?ieiiia
A.A., Oaoaiaaa E.A. e ae?., 1995).

A oiiaao ??ciiiai?oiiai ca nai?i neeaaeii caa?oaeiaiiy aoiinoa?iiai
iia?o?y aeanyoeaie oiene/ieo ?a/iaei (I?enyaeithe A.A. e ae?., 1995)
aeooaeueiei ? ?o ?iaeea?aeoaeueia oa eiiieaenia a?a??i?/ia
aeine?aeaeaiiy.

Aaaeeeaei iiiaioii i?e oeueiio ? aea?? aaeaeaaoieo iaoiae?a
aeine?aeaeaiiy. Nenoaia e?ia? — iaeia c iae?ooeea?oeo nenoai, yea
oaeaeei ?aaao? ia ci?ie aiiainoaco i?aai?cio aiane?aeie o?i?/iiai
iioeiaeaeaiiy (O?aooaiaa?a E. I. e ae?., 1987). O a?a??i?/i?e i?aeoeoe?
aeei?enoiao?oueny ?yae iaoiae?a aecia/aiiy a?eo?ioeeoa?ieo
oa?aeoa?enoee: aacio?eueii? ca?ienoino? (Eaca?iaa N., Noiaa N.,
Ea?eoeiia I. 1995), oa?iaioaoeaii? aeoeaiino? (Aeaneeia N.A., Iaiaaaa
A.I., 1994), oeeoiiao?e/ieo iieaciee?a (Aaa?ueyiiaa I.E, Aenaiiaa A.I. e
ae?., 1995) oa ?i.. A?ioanooaaiiy c aeei?enoaiiyi a?eo?ioeeo?a aea?
iiaeeea?noue aea/aoe aaiioiene/i?noue i?ia caa?oaeiaii? aiaee oa
iia?o?y, ?o e?iaoeeo oa ii?iaia? oa?aeoa?enoeee. Aeine?aeaeaiiy A.A.
Aeaaeaoiaa (1974), A.A. Ai?ii?ia, A.A.Eaioyeiaa (1989), A.I. E?aa/oea,
?.I. I?oaeeaiei (1991), N.A. Aeane?ii?, A.I. Iaia?ai? (1994), French
C.L., Baldwin L.A. (1995) oa ?i. na?ae/aoue i?i ia?niaeoeai?noue
canoinoaaiiy o a?a??i?/i?e i?aeoeoe? iaoiae?a aecia/aiiy aaiie?oe/ieo
aeanoeainoae a?eo?ioeeo?a oa eiioi?iaoe?eieo aeanoeainoae aaiiaeia?io,
cie?aia, eeneioii? ?acenoaioiino? a?eo?ioeeo?a oa ai?noo e?aaiaeieo oi?i
aaiiaeia?io, ui iiaeooue aooe ?iaeeeaoi?aie aaiioiene/iino?.

Iaeiei c aeooaeueieo caaaeaiue oieneeieia?? ? iioei?caoe?y iaoiae?a
aeine?aeaeaiiy oiene/ieo i?ioean?a, eio?? aeieeathoue a i?aai?ci? i?e
ae?? aaaaoueio aeoeaieo ?a/iaei (Eoiaeeaa TH.E., Ieeoeueneay E.A.,
1993). Oaeineiiaeaiiy a?eo?ioeeoa?ieo oano?a aeey a?a??i?/ii? ioe?iee
o?i?/ieo oaeoi??a iaaeieeoiueiai na?aaeiaeua c aeei?enoaiiyi
iaoaiaoe/iiai iiaeaethaaiiy ni?eyoeia iioei?caoe?? iaoiae?a
oieneeieia?/ieo aeine?aeaeaiue, ui ? aeooaeueiei aeey oieneeieia?? oa
a?a??ie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie: Aeine?aeaeaiiy
aeeiiaii a iaaeao iaoeiai-aeine?aeii? ?iaioe a?aeae?eo i?eeeaaeii?
o?c?ieia?? oa a?io?i?? IAe? caaaeueii? oa eiioiaeueii? a?a??ie ?i.
I.I.Ia?c??aa «?ac?aaioea iaoiaee/aneeo iiaeoiaeia e ioeaiea
iauaoiene/aneiai eiiaeie?iaaiiiai aeaenoaey aiaeiuo e aicaeooiuo
caa?ycieoaeae (ia iiaeaee nenoaiu e?iae)» (Oeo? IE.92.16.474, ? Ae?
0193U039169).

Iaoa aeine?aeaeaiiy: ?ic?iaeoe iaoiaee/i? i?aeoiaee aei aeei?enoaiiy
a?eo?ioeeoa?ii? iiaeae? aeey a?a??i?/ii? aeni?an-ioe?iee oiene/ii? ae??
o?i?/ieo oaeoi??a iaaeieeoiueiai na?aaeiaeua.

Caaea/? aeine?aeaeaiiy:

1. Aecia/eoe caeiiii??iino? ?cieueiaaii? ae?? (caeaaeiino? «/an — aoaeo»
oa «eiioeaio?aoe?y — aoaeo») aeayeeo o?i?/ieo oaeoi??a iaaeieeoiueiai
na?aaeiaeua (i?iaeoeo?a oei?oaaiiy oa iciioaaiiy aiaee, i?aai?/ieo
?ic/eiiee?a, nieae aaaeeeo iaoae?a) ia aaiioiene/i?noue c aeei?enoaiiyi
a?eo?ioeeoa?ii? iiaeae? ?n vitro.

2. Aeine?aeeoe aaiioiene/i?noue i?ia aiaeiiai oa iia?o?yiiai na?aaeiaeua
ia a?eo?ioeeoa?i?e iiaeae? ?n vitro.

C. C?noaaeoe ?acoeueoaoe aeine?aeaeaiue c aaiioiene/iino? oa
iooaaaiiino? o?i?/ieo oaeoi??a aiaeiiai oa iia?o?yiiai na?aaeiaeua c
aeaieie uiaei caaaeueii? oiene/iino? oeeo oaeoi??a.

4. ?ic?iaeoe iaoiaeeeo ?ic?aooieo ia?aiao??a aaiioiene/iino? ye
aeiiii?aeieo oa?aeoa?enoee i?e a?a??i?/i?e ioe?ioe? o?i?/ieo oaeoi??a
iaaeieeoiueiai na?aaeiaeua.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

A ?iaio? aia?oa aeine?aeaeaii caeaaeiino? «aeica-aoaeo» aeey
aaiioiene/ii? ae?? o?i?/ieo ?a/iaei ia a?eo?ioeeoa?i?e iiaeae? ?n vitro.

Aia?oa anoaiiaeaii caeiiii??iino? aieeao oaiieo, aoeaoaoo naeioeth oa
oei?aea?ae?aoo ia i?ioean iaoaaiiaeia?iooai?aiiy. Iiaeaeueoee ?icaeoie
ae?noaei aeine?aeaeaiiy aieeao ia iaoaaiiaeia?iooai?aiiy
aaicaeueaeaa?aeo, aaicieo, a?o?iiaoo eae?th, aooaiieo-1, a?ae?io?iiio,
aeeoei?aoaio, iiiioei?ioeoiai? eeneioe, i?o?aoo naeioeth, i?o?aoo
oea??th, ioeoiai? eeneioe, naeai?oo iao??th, oao?aoei?eaeo aoaeaoeth,
oi?iaeueaeaa?aeo, oo?oo?ieo, oei?eaeo eaioaio, oei?eaeo no?iioe?th.

Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue aia?oa ?ic?iaeaii iaoiaeeeo
?ic?aooieo ia?aiao??a aaiioiene/iino? c aeei?enoaiiyi a?eo?ioeeoa?ii?
iiaeae? oa iaoaiaoe/iiai iiaeaethaaiiy.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

Aeiaaaeaia iiaeeea?noue aeei?enoaiiy a?eo?ioeeoa?ii? iiaeae? aeey
a?a??i?/ii? aeni?an-ioe?iee aoaeoeaiino? ?iaioe i/enieo nii?oae a
caeaaeiino? a?ae niiniao aiaeii?aeaioiaee, a oaeiae caa?oaeiaiiy
iia?o?yiiai na?aaeiaeua i?no Oe?a?ie (ia i?eeeaae? i?ia aa?icieueii?
/anoeie iia?o?y Aeiiaoeueea, N?a??iaeiiaoeueea, Ia??oiiey, ??aiiai, Noi,
Naaanoiiiey).

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy: Iaoa??aee
aeine?aeaeaiiy aeei?enoiaoaaeenue o i?aeoe/i?e ?iaio? Ee?aaiaeieaiaeo
i?e ?ic?iaoe? iiaeo oaoiieia?/ieo ?aaeei?a aiaeii?aeaioiaee.

Ia iniia? io?eiaieo ?acoeueoao?a aeaeaii ?ioi?iaoe?eiee eeno ii i?iaeai?
«A?a??ia iaaeieeoiueiai na?aaeiaeua» ? 86-98 «Aeni?an-iaoiae
aecia/aiiy aaiioiene/iino? o?i?/ieo oaeoi??a ia i?aenoaa?
a?eo?ioeeoa?ii? iiaeae?» (Ee?a: Oe?iaaeiaoaio?ioi?i, 1998), yeee
ai?iaaaeaeaii a ?inoeooo? aeia?a??ie ? oieneeieia?? ?i. E. ?. Iaaeaaaey
oa o IAe? «Aeano?e» i?e ioe?ioe? iaoe?aeeeaino? iaoa??ae?a oa ae?ia?a,
ui eiioaeoothoue c e?ia’th, oa ae?ia?a ? iaoa??ae?a iaaee/iiai
i?ecia/aiiy.

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeaii o iaa/aeueiee i?ioean
iaaee/iiai oaeoeueoaoo eaoaae?e i?iiaaeaaoeee a?a??ie, a?enueeiai? oa
?aae?aoe?eii? a?a??ie (eo?n eaeoe?e oa i?aeoe/ieo caiyoue c
i?iiaaeaaoeee a?a??ie, ?icae?e «Iaoiaee a?a??ie») oa oaeoeueoaoo
i?aeaeuaiiy eaae?o?eaoe?? aeeeaaea/?a a?a??ie iaaee/ieo aoc?a oe?a?ie
(i?ia?aia ia?aeiiiai oeeeeo) Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i. 0.0. Aiaiiieueoey IIC Oe?a?ie.

Iniaenoee aianie caeiaoaa/a

Aeena?oaio iniaenoi i?iaiae?coaaa a?aeiia?aeio e?oa?aoo?o, naiino?eii
aeeiiaa ieaioaaiiy oa i?iaaaeaiiy aeine?aeaeaiue, aiae?c io?eiaieo
?acoeueoao?a, i?aeaioiaeo iaoa??ae?a aei ae?oeo. A ?iaio? aeei?enoaii
?acoeueoaoe aeine?aeaeaiue iooaaaiiino? iia?o?y, aeeiiaieo
eaiaeeaeaoii a?ieia?/ieo iaoe, noa?oei iaoeiaei ci?a?ia?oieeii,
caa?aeoaa/ai eaai?aoi??? a?i?iaeeeaoe?? iooaaai?a I.I. Aeoaaiii.
Iaoaiaoe/io ia?iaeo ?acoeueoao?a aeine?aeaeaiue aeeiiaii ca o/anoth
iieiaeoiai iaoeiaiai ni?a?ia?oieea eaai?aoi??? iaoaiaoe/ieo iaoiae?a o
a?a??i? A. I. ?e?ca?iaa. Ia’?i naiino?eieo aeine?aeaeaiue noaiiaeoue
85-90%.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??

?acoeueoaoe aeine?aeaeaiiy ii?eethaeiaii ia XIII c’?cae? a?a??i?no?a
Oe?a?ie «I??i?eoaoi? i?iaeaie a?a??i?/ii? iaoee, iaaee/ii? aeieia??,
nai?oa?ii? i?aeoeee oa ioi?iie caei?ia’y» (Ee?a, 1995), ia iaoeiaeo
nai?ia?ao a OIAOe IIC Oe?a?ie, ?inoeooo? iieieia?? oa ?aae?ieia?? IIC
Oe?a?ie.

Ioae?eaoe??

?acoeueoaoe aeena?oaoe?? iioae?eiaai? a 4 noaooyo o iaoeiaeo aeo?iaeao,
a C noaooyo o ca??ieeao iaoeiaeo i?aoeue, o 1 oacao XIII c’?caeo
a?a??i?no?a Oe?a?ie, ca iaoa??aeaie ?iaioe aeaeaiee 1 ?ioi?iaoe?eiee
eeno.

Ianya oa no?oeoo?a aeena?oaoe??

Aeena?oaoe?y aeeeaaeaia ia 146 noi??ieao iaoeiiieno, ?ethno?iaaia ?C
?enoieaie oa 43 oaaeeoeyie ? neeaaea?oueny ?c anooio, 5 ?icae?e?a,
aeniiae?a, nieneo aeei?enoaieo e?oa?aoo?ieo aeaea?ae (c? 221
iaeiaioaaiue, c yeeo 119 a?o/eciyieo oa e?a?i NIAe ? 102 ?iicaiieo) oa 5
aeiaeaoe?a.

INIIAIEE CI?NO

Iaoa??aee ? iaoiaee aeine?aeaeaiue

Aoee aeei?enoai? ianooii? iaoiaeeee: aecia/aiiy eeneioii? ?acenoaioiino?
a?eo?ioeeo?a (Aaca?iiaa I.A 1982), aecia/aiiy ai?noo iene-, aeaciene- oa
iaoaaiiaeia?io (Eooaeianeee I.N., 1968; Aanasch R.A., Aanesch R.A., Yung
S., 1973), iai?ae?euee?nia aeine?aeaeaiiy iooaaaiiino? o?i?/ieo ?a/iaei
(Ames at al., 1973) c aeei?enoaiiyi aeaio oano-ooai?a Salmonella
typhymurium (OA 100 ? OA 98) oa ia/?ieiai? o?aeoe?? 8-9, io?eiaii? a?ae
6 naioe?a uo??a e?i?? A?noa?.

I?iaaaeaii 58 na??e aenia?eiaio?a, c ieo 47 c aea/aiiy aaiioiene/iino?
oa 11 c aea/aiiy iooaaaiiino?. A aenia?eiaioao aoei aeei?enoaii 28 i?ia
e?ia? aa?aia.

A oe?eiio aeine?aeaeaii 19 o?i?/ieo ?a/iaei, ye? aoee ia?aaaaeii
aiaeieie aai oa?ea?oa?ieie caa?oaeithaa/aie (aoeaoao naeioeth,
aaicaeueaeaa?ae, aaicie, a?o?iiao eae?th (AE), aooaiie-?, a?ae?io?iii,
aeeoei?aoai, iiiioei?ioeoiaa eeneioa (IOI), i?o?ao naeioeth, i?o?ao
oea??th, ioeoiaa eeneioa (IE), naeai?o iao??th, oao?aoei?eae aoaeaoeth
(OOA), oaiie, oi?iaeueaeaa?ae, oo?oo?ie, oei?aea?ae?ao, oei?eae eaioaio,
oei?eae no?iioe?th), 7 oei?a i?ia aiaee, eio?? aoee iaea?aeai? ia ??cieo
aoaiao aiaeii?aeaioiaee (aeo?aeia aiaea (AA), oei?oaaiiy (aeice
aeoeaiiai oei?o 5 ia/e oa 10 ia/e), iciioaaiiy (aeice iciio 4,25 ia/e oa
6 ia/e), a?aenoithaaiiy, o?eueo?aoe?y, aoi?eiia iciioaaiiy oa aoi?eiia
oei?oaaiiy), 6 oei?a i?ia aa?icieueii? /anoeie aoiinoa?iiai iia?o?y i?no
Oe?a?ie (Aeiiaoeuee, Ia??oiieue, ??aia, Naaanoiiieue, N?aa?iaeiiaoeuee,
Noie).

E?i?ooth/ith iciaeith i?e iaa?oiooaaii? AAeE aeine?aeaeaieo o?i?/ieo
?a/iaei aoea ia?aaaaeii nai?oa?ii-oieneeieia?/ia, ca aeiyoeii
aaicaeueaeaa?aeo, a?ae?io?iiio, oo?oo?ieo, oaiieo (i?aaiieaioe/ia) oa IE
(caaaeueiinai?oa?ia). C iaoith c’ynoaaiiy /ooeeaino? oa ?ioi?iaoeaiino?
cai?iiiiiaaieo iaoiae?a a?a??i?/ii? aeni?an-ioe?iee aea?ai? ?a/iaeie, ui
oa?aeoa?ecothoueny ??ciei eeanii iaaaciaee oa ??cieie oeiaie o?iiiiai
aieeao ia ethaeeio.

?acoeueoaoe aenia?eiaio?a ia?iaeaii ca aeiiiiiaith caaaeueiii?eeiyoeo
iaoiae?a iaoaiaoe/ii? noaoenoeee, oaeiae i?iaaaeaii iaoaiaoe/ia
iiaeaethaaiiy aeeiai?ee aaiie?co.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy

Aenia?eiaioaeueia aeine?aeaeaiiy aeeth/aei i’youe aoai?a. Ia?oee
(i?aeaioia/ee) — a?aei?aoethaaiiy iaoiaeee, aea/aiiy aieeao eiina?aaioo
aeeiaoeenoeueoieneaeo (AeINI) ia aaiie?c ee?oei. Ae?oaee — aecia/aiiy
iiaeeeaino? canoinoaaiiy a?eo?ioeeoa?ii? iiaeae? aeey c’ynoaaiiy
aaiioiene/iino? o?i?/ieo ?a/iaei-caa?oaeithaa/?a aiaee oa iia?o?y.
O?ao?e — aiae?c aaiioiene/iino? i?ia aiaee oa iia?o?y. *aoaa?oee —
aeine?aeaeaiiy iooaaaiii? aeoeaiino? aeayeeo o?i?/ieo ?a/iaei, a oaeiae
i?ia aiaee ia ??cieo aoaiao aiaeii?aeaioiaee. I’yoee — ?ic?iaea
iaoiaeeee ?ic?aooieo ia?aiao??a aaiioiene/iino?.

Aeei?enoaiiy a?eo?ioeeoa?ii? iiaeae? aeey aecia/aiiy aaiioiene/iino?
o?i?/ieo ?a/iaei

Ia i?aeaioia/iio aoai? aeine?aeaeaiue aoea aecia/aia iioeiaeueia
eiioeaio?aoe?y aaiie?oe/iiai ?ic/eio (0,0001 i IN?) oa i?iaaaeai?
aenia?eiaioe c aea/aiiy iiaeeeai? ae?? AeINI (a eiioeaio?aoe?yo 5, 10,
15, 20, 25oa 30iee/e), eio?ee ? ?ic/eiieeii i?ia aiaee oa iia?o?y, ia
i?ioean aaiie?co a?eo?ioeeo?a. A ?acoeueoao? c’yniaaii, ui o aeacaiiio
ae?aiacii? eiioeaio?aoe?e AeINI ia aieeaaa ia oaeaee?noue aaiie?co
a?eo?ioeeo?a.

C aeei?enoaiiyi iaoiaeo aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a
i?iaaaeai? aeine?aeaeaiiy 19-oe o?i?/ieo ?a/iaei-caa?oaeithaa/?a ia
iayai?noue aaiioiene/iino?. On? ?a/iaeie aoee iine?aeiaii oeo?iaai? c
o?aooaaiiyi ?o ?ic/eiiino?.

A ?acoeueoao? i?iaaaeaiiy na??? aenia?eiaio?a niinoa??aaeeny o?e oeie
?aaaoaaiiy «?a/iaeia-a?eo?ioeeo»: iiceoeaiee, iaaaoeaiee oa
iaeo?aeueiee, ye? iaaaaeai? ia ?en.1.

Aei ?a/iaei, ye? aeaiiino?othoue iiceoeaiee oei ?aaaoaaiiy, a?aeianee
IOI, oi?iaeueaeaa?ae, IE, oo?oo?ie, aaicaeueaeaa?ae oa oaiie. Oe?
?a/iaeie i?iyaeyee ae?aaeaio aaiie?oe/io aeoeai?noue. Aeey ieo
oa?aeoa?ia ianooiia caeaaei?noue «eiioeaio?aoe?y-aoaeo»: c iine?aeiaiei
ciaioaiiyi eiioeaio?aoe?? ?a/iaeie iieaciee /ano 50°/i-ai aaiie?co
ee?oei iaaeeaeaany aei eiio?ieth. Oea aeicaieeei aecia/eoe
eiioeaio?aoe?? ?a/iaei, ye? ciaiooaaee i?ioean eiio?ieueiiai aaiie?co o
aeaa ?ace. Aeey IOI oey eiioeaio?aoe?y neeaaeaea 0,0065 ia/ie, aeey IE —
0,0012 iee/ie, aeey oi?iaeueaeaa?aeo — 5 ia/ie, aeey aaicaeueaeaa?aeo —
0,19 iee/ie, aeey oo?oo?ieo -11,2 iee/ie, aeey oaiieo — 0,55 ia/ie.
Oaeiae aoei ?ico?aoiaaii ?ioaa?aeuei? oa?aeoa?enoeee i?ioeano aaiie?co
oa caeaaei?noue iaea oaeee aeae: o=a+bx (aea o -?ioaa?aeuei? ioe?iee
aeeiai?ee, o — cia/aiiy eiioeaio?aoe?? oaeoi?a, a, b — eiao?oe??ioe
iiaeae?).

Aei ?a/iaei c iaeo?aeueiei oeiii ?aaaoaaiiy aoee a?aeianai?
oei?aea?ae?ao, oei?eae eaioaio, AE oa i?o?ao oea??th, ye? ia ni?aaeyee
a??ia?aeiiai aieeao ia oaeaee?noue aaiie?co o aeine?aeaeaiiio ae?aiacii?
eiioeaio?aoe?e (Aeea. ?en. 1).

Aei ?a/iaei c iaaaoeaiei oeiii ?aaaoaaiiy a?aeianee aaicie, aeeoei?aoai,
i?o?ao naeioeth, oei?eae no?iioe?th, aoeaoao naeioeth, a?ae?io?iii, OOA,
aooaiie-1 oa naeai?o iao??th. Iieaciee /ano 50%-ai aaiie?co aeey ?a/iaei
oe??? a?oie aoa aai nooo?ai a?eueoei ca eiio?ieueiee (iai?eeeaae, aeey
i?o?aoo naeioeth o eiioeaio?aoe?yo 4 ia/ie (3 oa), 2 ia/ie (3,97 oa), 1
ia/ie (3,585 oa) eiio?ieue (1,76 oa)) aai acaaae? ia i?a aooe aecia/aiee
(Aeea. ?en. 1 — ia i?eeeaae? aoeaoaoo naeioeth) /a?ac a?aenooi?noue
a??ia?aeieo iciae aaiie?co i?ioyaii /ano niinoa?aaeaiiy, ?iia??ii, o
ca’yceo c i?ioiaeaeaiiyi aioaaii?noe/iiai i?ioeano ou?eueiaiiy iaia?ai
a?eo?ioeeo?a. Ia ei?enoue oeueiai na?ae/eoue i?aeaeuaiiy iieacieea
aenoeioe?? a?eo?ioeeoa?ii? noi?o? i?e a?aenooiino? ooai?aiiy inaaeeo.

Ca ?acoeueoaoaie aecia/aiiy ai?noo e?aaiaeieo oi?i aaiiaeia?io
aeine?aeaeoaai? ?a/iaeie aoei ?icae?eaii ia 2 a?oie. Ia?oo a?oio neeaee
oei?aea?ae?ao, oei?eae no?iioe?th, oei?eae eaioaio, naeai?o iao??th,
aooaiie-1 oa aeeoei?aoai. Aeiaeaaaiiy oeeo ?a/iaei nooo?ai ia ci?ithaaei
ai?no iene- aeaciene- oa iaoaaiiaeia?io o oano-nenoai?. Aei ae?oai?
a?oie a?aeianee oaiie, aoeaoao naeioeth, i?o?ao naeioeth,
oi?iaeueaeaa?ae, i?o?ao oea??th. Aeiaeaaaiiy oeeo ?a/iaei nooo?ai
i?aeaeuoaaei ai?no iaoaaiiaeia?io oa, a?aeiia?aeii, cieaeoaaei ai?no
iene- oa aeacieneaaiiaeia?io. Iai?eeeaae, aeiaeaaaiiy oi?iaeueaeaa?aeo o
eiioeaio?aoe?yo 0,5-2 ia/ie o 3,8 ?ace i?aeaeuoaaei ai?no iaoaaiiaeia?io
a a?eo?ioeeoao. Aeey oaiieo (10-5 ia/ie) i?aeaeuaiiy ai?noo
iaoaaiiaeia?io neeaaeaei 1,3-1,7 ?ace, aeey aoeaoaoo naeioeth (1-0,1
ia/ie) o 2,1-2,7 ?ace, aeey i?o?aoo naeioeth (4-? ia/ie) o 3,4-3,7 ?ace.
I?o?ao oea??th i?e ianooo?aiio aieea? ia ai?no iaoaaiiaeia?io cieaeoaaa
ai?no ieneaaiiaeia?io o 1,2 — 1,7 ?ace oa i?aeaeuoaaa ai?no
aeacieneaaiiaeia?io o 2,3 — 3,4 ?ace. Aoei aecia/aii eiioeaio?aoe??, ye?
iaea?eueo ci?iththoue i?ioean ooai?aiiy e?aaiaeieo oi?i. Aeey i?o?aoo
oea??th oea 0,2 ia/ie, aeey oaiieo — 7 ia/ie, aeey aoeaoaoo naeioeth —
0,2 ia/ie, aeey i?o?aoo naeioeth — 4 ia/e, aeey oi?iaeueaeaa?aeo — 2
ia/ie. Ioaea, aecia/aiiy ai?noo e?aaiaeieo oi?i aaiiaeia?io aeicaieeei
aea/eoe aieea aaaeeeo iaoae?a oa ?ioeo oiene/ieo ?a/iaei ia
eiioi?iaoe?ei? aeanoeaino? aaiiaeia?io.

Oa?aeoa? aieeao aeine?aeaeaieo ?a/iaei ia aeeiai?eo ai?noo iene-,
aeaciene- oa iaoaaiiaeia?io a a?eo?ioeeoao a?ae??ciyany a?ae ?o aieeao
ia i?ioean aaiie?co: ?a/iaeie, ui aeoeaii aieeaaee ia ai?no e?aaiaeieo
oi?i aaiiaeia?io, iaeaaeaee aei ??cieo a?oi ca aieeaii ia i?ioean
aaiie?co a?eo?ioeeo?a. I/aaeaeii, oea iia’ycaii c ??cieie iaoai?ciaie
ae?? ?a/iaei ia a?eo?ioeeoe (aieea ia iaia?aio a?eo?ioeeo?a, aai
aaciina?aaeiuei ia aaiiaeia?i). Oaeei /eiii, aecia/aiiy ai?noo
e?aaiaeieo oi?i aaiiaeia?io aeiiiaith? aecia/aiiy eeneioii?
?acenoaioiino? a?eo?ioeeo?a i?e aea/aii? aaiioiene/iino? o?i?/ieo
caa?oaeithaa/?a. Iniaeeai oea ia? cia/aiiy aeey nieae aaaeeeo iaoae?a,
eio??, ca aeaieie iaoiai aeine?aeaeaiiy, caeaoi? aaeueioaaee i?ioean
aaiie?co a?eo?ioeeo?a.

Aenia?eiaioaeuei? aeai? uiaei ia?aa??aieo ia aaiioiene/i?noue ?a/iaei
aoee i?iaiae?ciaai? c o?aooaaiiyi ?o eean?a iaaaciaee, e?i?ooth/eo
iieaciee?a oe?aeeeaino? oa caaaeueiioiene/ieo aeanoeainoae.
A?aecia/a?oueny aeniea /ooeea?noue oa ?ioi?iaoeai?noue iaoiaeo
aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a aeey ie?aieo
?a/iaei-caa?oaeithaa/?a iae?io?iiii? ae??. Ia aoei aeyaeaii a??ia?aeii?
caeaaeiino? i?ae e?i?ooth/eie iieacieeaie oe?aeeeaino? ?a/iaei oa ?o
aaiie?oe/ieie aeanoeainoyie, eio?? aoei aeine?aeaeaii ia a?eo?ioeeoa?i?e
iiaeae?.

Aeei?enoaiiy a?eo?ioeeoa?ii? iiaeae? aeey aeni?an-aiae?co i?ia aiaee oa
iia?o?y

Ca aeiiiiiaith oanoo aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a
aoa i?iaaaeaiee aiae?c na?aaeiueii?ny/ieo i?ia ieoii? aiaee (/a?aaiue
1996 ?ieo), io?eiaii? c Aei?i?ianueeiai aiaeii?iaiaeo ia ??cieo aoaiao
aiaeii?aeaioiaee, oa i?ia aa?icieueii? /anoeie aoiinoa?iiai iia?o?y
aeayeeo i?no Oe?a?ie (Aeiiaoeuee, Ia??oiieue, ??aia, Naaanoiiieue,
N?aa?iaeiiaoeuee, Noie).

?acoeueoaoe aenia?eiaioaeueiiai aeine?aeaeaiiy aaiioiene/iino? i?ia
ieoii? aiaee ca aeiiiiiaith aeaiiai oanoo iaaaaeai? o oaaeeoe? 1.

Oaaeeoey 1. Caeaaei?noue iieacieea aenoeioe?? noi?o? a?ae /ano aaiie?co
aeey i?ia ieoii? aiaee ia ??cieo aoaiao aiaeii?aioiaee

*an, oa Iieacieee aenoeioe?? noi?o? a aeine?aeaeaieo i?iaao aiaee,
iio. iae.

eiio?ieue 1 2 3 4 5 6 7

0 0,5800* 0,5925* 0,4870*** 0,6040 0,5710* 0,6021 0,5250* 0,5530**

0,5 0,5245 0,5123* 0,4415** 0,5445* 0,5390* 0,5572* 0,4805** 0,5345*

1,0 0,4610 0,4452* 0,3960** 0,4755* 0,4840* 0,4785* 0,4375* 0,4975**

1,5 0,4075 0,3872* 0,2955*** 0,3865* 0,4055 0,4168* 0,3970* 0,4455*

2,0 0,3630 0,3386* 0,1710*** 0,2965** 0,3270* 0,3481* 0,3570* 0,3805*

2,5 0,3230 0,3062* 0,0965*** 0,2285** 0,2610* 0,2860** 0,3000* 0,3075*

3,0 0,2890 0,2789 0,0640*** 0,1765** 0,2105* 0,2294** 0,2614* 0,2560*

3,5 0,2600 0,2592

0,1400** 0,1730** 0,1869** 0,2060** 0,2250*

4,0 0,2340 0,2341

0,1070** 0,1435** 0,1487** 0,1595** 0,1950*

4,5 0,2110 0,2109

0,1210** 0,1812*

0,1715*

5,0 0,1920 0,1876

0,1080**

0,1535*

O501 3,10 2,51* 1,60** 1,90** 2,21** 2,46* 2,85* 2,75*

I?ei?oea. O501 — iieaciee /ano 50%-ai aaiie?co a?eo?ioeeo?a o oaeeeiao

* ?<0,05; ** p<0,01; *** p<0,005 o ii??aiyii? c eiio?ieai Iaea?aeai? ?acoeueoaoe na?ae/aoue, ui ia?aeiia oei?oaaiiy aeo?aeii? aiaee (AA -i?iaa 1) i?ecaiaeeoue aei ooai?aiiy aaiioiene/ieo i?iaeoeo?a (c a?oie oei?i?aai?/ieo ?a/iaei). Iaea?eueoa ae?aaeai?noue oeueiai aoaeoo niinoa??aaeany i?e aeei?enoaii? aeice aeoeaiiai oei?o 5 ia/e (i?iaa 2- aeo?aeia aiaea (AA) + 5 ia/e aeoeaiiai oei?o), eio?a iaeaea aaea?/? i?enei?thaaea aaiie?c a?eo?ioeeo?a (O50 - 1,6 oa; i?iaa 1 - 2,51oa, eiio?ieue - 3,1 oa), oiae? ye aeica 10 ia/e aeoeaiiai oei?o - i?iaa 3 (O50 - 1,9 oa) oa iciioaaiiy (i?iaa 4 - AA+ 4,25 ia/e iciio, O50 = 2,21 oa; i?iaa 5 - AA+6 ia/e iciio, O50 = 2,46 oa) aoee iaio oiene/ieie. I?iae i?ney oaoi?/iiai eaioethaa: 6 - AA i?ney iciioaaiiy, eiaaoeyoe??, a?aenoithaaiiy, o?eueo?aoe?? oa oei?oaaiiy oa 7 - AA i?ney oei?oaaiiy, eiaaoeyoe??, a?aenoithaaiiy, o?eueo?aoe?? oa aoi?eiiiai oei?oaaiiy, i?aeoe/ii ia a?ae??ciyeeny a?ae eiio?ieth. Oaeei /eiii aeei?enoaiiy aeoeaiiai oei?o aeey ciaca?aaeoaaiiy ieoii? aiaee o e?oi?e /an ??cei i?aeaeuoaaei ?? aaiioiene/i?noue (O50 nei?i/oaaany iaeaea aaea?/?), ui, i/aaeaeii, iia'ycaii c ooai?aiiyi a?eueoi? e?eueeino? oei?i?aai?/ieo ?a/iaei. I?aeaeuaiiy aaiioiene/iino? aiaee i?ae aieeaii aoei iaio ae?aaeaiei (O50 nei?i/oaaany o 1,4- 1,2 ?ace). A e?ioe? oaoi?/iiai eaioethaa aiaeii?aeaioiaee iieacieee aaiioiene/iino? ieoii? aiaee nooo?ai ia a?ae??ciyeeny a?ae eiio?ieueieo. Io?eiai? iaie aeai? ocaiaeaeothoueny c ?acoeueoaoaie aeine?aeaeaiue eaai?aoi??? Ee?aaiaeieaiaeo ai?noo i?aai?/ieo niieoe o aiae?, ca?aeii c yeeie i?ney oei?oaaiiy o aeic? 5 ia/e ??cei i?aeaeuoaaany ai?no ea?aiiiaeo eeneio (N14, N18), 2,4,6-o?eoei?oaiieo, oei?ioi?io, a?iiaeeoei?iaoaio, aeea?iioei?iaoaio, o?eoei?aoaio, aeeoei?- ? o?eoei?ioeoiaeo eeneio, a i?ney canoinoaaiiy aeoeaiiai oei?o o aeic? 10 ia/e - ciaiooaaany ai?no ea?aiiiaeo eeneio (N12, N14, N16, N18) oa aeea?iioei?iaoaio. Oaeei /eiii iiaeia c?iaeoe aeniiaie i?i iiaeeea?noue canoinoaaiiy iaoiaeo aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a aeey aeni?an-ioe?iee aaiioiene/iino? i?ia ieoii? aiaee iaa?aeiiiai neeaaeo, cie?aia, a oiiaao a?a??i?/ii? ioe?iee canoinoaaiiy iiaeo cania?a aiaeii/euaiiy. ?acoeueoaoe aiae?co aaiie?oe/ii? aeoeaiino? i?ia aa?icieueii? /anoeie aoiinoa?iiai iia?o?y 6-oe i?no Oe?a?ie iaaaaeaii ia ?enoieo 2. sse aeaeii c ?enoiea 2, eiioeaio?aoe i?ia iia?o?y i?no Ia??oiiey, Aeiiaoeueea oa N?a??iaeiiaoeueea i?enei?thaaee i?ioean aaiie?co: iieaciee /ano 50°/i-ai aaiie?co (O50) aeey i?iae iia?o?y i?noa Ia??oiieue noaiiaea 1,96 oa (?<0,001), aeey i?iae Aeiiaoeueea -2,11 oa (?<0,001), aeey N?a??iaeiiaoeueea - 2,32 oa (?<0,001) i?e 2,76 oa eiio?ie?. Aaiie?oe/ia aeoeai?noue i?ia iia?o?y i?no ??aia oa Noie aoea ieae/ith, i?ae o iiia?aaei?o i?noao, i?ioa aeuith i?ae o eiio?ie? (2,43 oa (?<0,05) ? 2,56 oa (?<0,05). I?iaa iia?o?y i?noa Naaanoiiiey ca aaiie?oe/iith aeoeai?noth noaoenoe/ii ia a?ae??ciyeanue a?ae eiio?ieth (O50 - 2,65 oa (?<0,05)). Ca aeaieie Aea?aeaaiiai eii?oaoo Oe?a?ie c a?ae?iiaoai?ieia?? (1992) ??aaiue caa?oaeiaiiy iia?o?y i?no Aeiiaoeueea, Ia??oiiey oa N?aa?iaeiiaoeueea aoa aeuee ca na?aaei?e, a Aeiiaoeuee oa Ia??oiieue aoee a?aeianai? aei ?yaeo i?no c iaea?eueoei ??aiai caa?oaeiaiiy iia?o?y i?no Noie, ??aia oa Naaanoiiieue aoa ieae/ei ca na?aaei?e, ui ni?aiaaea? c ?acoeueoaoaie iaoeo aeine?aeaeaiue. Ii??aiyeueiee aiae?c aeicaiey? c?iaeoe aeniiaie i?i iayai?noue ye?niiai ca’yceo i?ae aaiioiene/i?noth i?ia aoiinoa?iiai iia?o?y oa ai?noii o iueiio ?yaeo oiene/ieo ?a/iaei (ca aeaieie Oe?a?ae?iiaoo), ye? iathoue ae?aaeaio aaiie?oe/io aeoeai?noue ca?aeii c ?acoeueoaoaie iaoeo aeine?aeaeaiue, a oaeiae aeaco? ia iiaeeea?noue aeei?enoaiiy iaoiaeo aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a aeey aeni?an-oanooaaiiy aaiioiene/iino? i?ia aoiinoa?iiai iia?o?y iaa?aeiiiai neeaaeo. Aeei?enoaiiy oanoo Aeina aeey ioe?iee iooaaaiii? aeoeaiino? o?i?/ieo oaeoi??a aiaeiiai oa iia?o?yiiai na?aaeiaeua Aoea i?iaaaeaia na??y aenia?eiaio?a ii aecia/aiith iooaaaiii? aeoeaiino? ye ?iaeea?aeoaeueieo o?i?/ieo ?a/iaei, oae ? aeuaaeacaieo i?ia aiaee ? iia?o?y. Na?aae aeine?aeaeaieo ?a/iaei iooaaaiio aeoeai?noue iaee oi?iaeueaeaa?ae, i?o?ao naeioeth, aeeoei?aoai, AE oa aoeaoao naeioeth. Iooaaaii? aeanoeaino? aooaiieo-1, IE oa naeai?oo iao??th anoaiiaeaii ia aoei. Niinoa??aaeany /?oea a?aeiia?aei?noue i?ae aeine?aeaeaiiyie aaiioiene/iino? oa iooaaaiiino? i?ia ieoii? aiaee oa aoiinoa?iiai iia?o?y. Iai?eeeaae, iaeneiaeueia iooaaaiia aeoeai?noue aoea ca?a?no?iaaia aeey i?iae aiaee, oei?iaaii? o aeic? 5 ia/e (aeey aeine?aeaeaiiy ca aeiiiiiaith oano-ooaio OA98 i?e iaoaaie?/i?e aeoeaaoe?? (IN+) iieaciee E (ni?aa?aeiioaiiy Oi /Oe aeine?aeo aei eiio?ieth) neeaaeaa 11,5, aac iaoaaie?/ii? aeoeaaoe?? (IN-) E - 11,0; i?e aeei?enoaii? oano-ooaio OA100 i?e IN+ E neeaaeaa 7,2, i?e IN- E aei??aithaaa 0,3). Iooaaaiia aeoeai?noue i?ia iciiiaaii? aiaee oaeiae aoea cia/ii ieae/ith, i?ae oei?iaaii? (aeey oano-ooaio OA98 i?e IN+ iieaciee E neeaaeaa 2,2, i?e IN- - 5,0; aeey oano-ooaio OA100 i?e IN+ iieaciee E aei??aithaaa 3,0, i?e IN- a?i neeaaeaa 4,0). Aeey i?ia aa?icieueii? /anoeie iia?o?y i?no Oe?a?ie, ye ? o iiia?aaeiueiio aeiaaeeo, niinoa??aaeany iaeii/ania i?enooi?noue aaiioiene/ii? oa iooaaaiii? aeoeaiino?. Iaea?eueo aenie? iieacieee iooaaaiiino? o ia?aaaaei?e a?eueoino? aeine?ae?a aoee cao?eniaai? o iia?o?? i?noa Ia??oiieue. Iieaciee E aeey oeueiai i?noa aoa iaeneiaeueiei ye i?e IN+ ooai?a OA 98 (29,0) oa OA 100 (7,3), oae ? i?e IN- aeey oano-ooai?a (OA 98 - 20,5; OA 100 - 7,5). Uiaei Aeiiaoeueea, oi iieacieee iooaaaiii? aeoeaiino? aoee aeaui ieae/eie ca aiaeia?/i? iieacieee Ia??oiiey: iieaciee E aeey ooaio OA 98 i?e IN+ neeaaeaa 19,5, i?e IN- - 15,6, aeey ooaio OA 100-8,2 oa 6,2, a?aeiia?aeii. Iia?o?y i?noa N?aa?iaeiiaoeuee iaei na?aaeith iooaaaiio aeoeai?noue: iieacieee iooaaaiiino? aoee ieae/? i?ae o Aeiiaoeueeo oa Ia??oiie?, aea aeu?, i?ae o ??aiiio oa Noiao. ??ai? iooaaaiii? aeoeaiino? i?ia aoiinoa?iiai iia?o?y i?no Noie oa ??aia aoee i?eaeecii iaeiaeiaeie. Iooaaaii?noue iia?o?y oeeo i?no aoea neaaeith. I?i?iaeueieie aoee iieacieee iooaaaiiino? i?ia iia?o?y i?noa Naaanoiiieue: aeey oano-ooaio Salmonella typhimurium OA 98 i?e IN+ iieaciee E neeaaeaa 4,7; i?e IN- - 3,4, aeey oano-ooaio OA 100 i?e IN+ iieaciee E neeaaeaa 1,6; i?e IN- - 1,5. Aeei?enoaiiy iaoiaeeee ?ic?aooieo ia?aiao??a aaiioiene/iino? aeey a?a??i?/ii? ioe?iee o?i?/ieo ?a/iaei-caa?oaeithaa/?a aiaee oa iia?o?y Iaea?aeai? iaie ?acoeueoaoe aeicaieeee i?iaanoe aiae?c aaiioiene/iino? oa iooaaaiiino? aea/aieo niieoe, aeyaeoe i?i?iaeuei? aaiie?oe/i? eiioeaio?aoe?? o?i?/ieo ?a/iaei (IAE) (i?e yeeo cia/aiiy ooieoe?? aoaea aei??aithaaoe eiio?ieueiiio ?c a?aooaaiiyi aeia??/iai ?ioa?aaeo) ca aeiiiiiaith iaoiaeeee ?ic?aooieo ia?aiao??a aaiioiene/iino?. Aeey ?ic?aooieo ia?aiao??a aaiioiene/iino? o?i?/ieo ?a/iaei ie aeei?enoiaoaaee iaoaiaoe/iee iien caeaaeiinoae "eiioeaio?aoe?y (o) - /an (1) - aoaeo (o)". Caeaaei?noue a?ae /ano (1) ioe?ithaaeany ca aeiiiiiaith ?ioaa?aeueieo iieaciee?a (A,A,N), eio?? ? aoee cia/aiiyie aoaeoo (o) i?e ?ic?aooieo IAE. Oi/a ca aeaiith iaoiaeeeith iaoaiaoe/ii aoee ia?aa??ai? an? 19 ?a/iaei, iaeiae aecia/aiiy IAE iiaea aooe aeciaia aaeaeaaoiei eeoa aeey ?a/iaei, ye? iaee aaiie?oe/iee aoaeo. Oaeei /eiii, anoaiiaeai? IAE iiaeooue aooe aeei?enoai? ye aeiaeaoeia? oa?aeoa?enoeee aeey o?i?/ieo ?a/iaei, eio?? iathoue aaiie?oe/i? aeanoeaino?. I?e aeei?enoaii? iaoiaeeee ?ic?aooieo ia?aiao??a aaiioiene/iino? iiaeeeaei ? aecia/aiiy IAE aoaeue-yei? ?a/iaeie-aaiie?oeea. AENIIAEE 1. Aei?iaoaai? o ?iaio? iaoiaee aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a oa ai?noo iene-, aeaciene- oa iaoaaiiaeia?io aeicaieythoue aeaoe ii??aiyeueio aeni?an-ioe?ieo aaiioiene/iino? ?iaeea?aeoaeueieo o?i?/ieo ?a/iaei-caa?oaeithaa/?a ? i?ia aiaeiiai oa iia?o?yiiai na?aaeiaeua iaa?aeiiiai neeaaeo. 2. Aoee ?ic?aoiaai? ?ioaa?aeuei? iieacieee aaiie?co oa aeyaeaia iaoaiaoe/ia caeaaei?noue ?o a?ae eiioeaio?aoe??. Anoaiiaeaii ?nioaaiiy o?ueio oei?a caeaaeiino? ?acenoaioiino? a?eo?ioeeo?a a?ae eiioeaio?aoe?? o?i?/ii? ?a/iaeie (iiceoeaiiai, iaaaoeaiiai oa iaeo?aeueiiai), eio?? ca'ycai? c ??cieie iaoai?ciaie ae??. I?e iiceoeaiiio oei? ?aaaoaaiiy (aaicaeueaeaa?ae, iiiioei?ioeoiaa oa ioeoiaa eeneioe, oaiie, oi?iaeueaeaa?ae, oo?oo?ie) aeii?io? i?ioean aaciina?aaeiueiai ?oeioaaiiy a?eo?ioeeoa?ii? iaia?aie c iiaeaeueoei aeoiaeii ai?noo ee?oeie iaciai?. I?e iaaaoeaiiio oei? (aoeaoao naeioeth, aaicie, aooaiie-1, a?ae?io?iii, aeeoei?aoai, i?o?ao naeioeth, naeai?o iao??th, oao?aoei?enoee aoaeaoeue, oei?eae no?iioe?th) aaiie?c ee?oei a?aenooi?e oa, iiaeeeai, ia? i?noea i?ioean ou?eueiaiiy iaia?ai a?eo?ioeeo?a. I?e iaeo?aeueiiio (a?o?iiao eae?th, i?o?ao oea??th, oei?aea?ae?ao, oei?eae eaioaio) niinoa??aa?oueny a?aenooi?noue yaieo iciae aieeao ia aaiie?c a?eo?ioeeo?a o ii??aiyii? c eiio?ieai. Aecia/aiiy ai?noo e?aaiaeieo oi?i aaiiaeia?io aeiiiaith? aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a i?e aea/aii? aaiioiene/iino? o?i?/ieo caa?oaeithaa/?a. Iniaeeai oea ia? cia/aiiy aeey nieae aaaeeeo iaoae?a, eio??, ca aeaieie iaoiai aeine?aeaeaiiy, caeaoi? aaeueioaaee i?ioean aaiie?co a?eo?ioeeo?a. 3. Aeiaaaeai? ci?ie aaiioiene/iino? oa iioaioe?eii? iooaaaiiino? aiaee a caeaaeiino? a?ae noaae?? aiaeii?aeaioiaee (ia i?eeeaae? ieoii? aiaee, ui io?eiaia ?c Ee?anueeiai aiaeii?iaiaeo o e?oi?e ia??iae 1996 ?ieo). I?e oei?oaaii? ieoii? aiaee o aeic? 5 ia/e aeoeaiiai oei?o iieacieee aaiioiene/iino? aoee iaeneiaeueieie (a??ia?aeia ia?aaeuaiiy eiio?ieth iaeaea aaea?/?), ??aaiue iooaaaiiino? ca oanoii Aeina o 11,5 ?ac?a ia?aaeuoaaa eiio?ieue. 4. Iciioaaiiy ieoii? aiaee (yea aoea io?eiaia ?c Ee?anueeiai aiaeii?iaiaeo o e?oi?e ia??iae 1996 ?ieo) iie?iooaaei iieacieee aaiioiene/iino? oa iioaioe?eii? iooaaaiiino? o ii??aiyii? ?c oei?oaaiiyi. Aeei?enoaiiy iciio aeey ciaca?aaeoaaiiy ciaiooaaei ??aaiue aaiioiene/iino? aiaee o 1,5 ?ace oa ?? iioaioe?eio iooaaaii?noue o 3,8 ?ace o ii??aiyii? ?c oei?oaaiiyi. 5. Ca ?acoeueoaoaie aeine?aeaeaiue aaiioiene/iino? i?ia aoiinoa?iiai iia?o?y 6 i?no Oe?a?ie (Aeiiaoeuee, N?aa?iaeiiaoeuee, ??aia, Ia??oiieue, Noie, Naaanoiiieue) iaea?eueo iani?eyoeeaei aeyaeeinue iia?o?y i?no Ia??oiiey (iieacieee aaiie?co o 1,4 ?ace ia?aaeuoaaee eiio?ieue). Aeiiaoeueea ( o 1,3 ?ace), N?a??iaeiiaoeueea (o 1,2 ?ace). Iieacieee aaiie?co i?iae aa?icieueii? /anoeie iia?o?y i?noa Naaanoiiieue a?aeiia?aeaee eiio?ieueiei. 6. Ca aeiiiiiaith ?ic?iaeaii? iaie iaoiaeeee ?ic?aooieo ia?aiao??a aaiioiene/iino? ?a/iaei-caa?oaeithaa/?a aiaee oa iia?o?y aoee anoaiiaeai? ?o i?i?iaeuei? aaiie?oe/i? eiioeaio?aoe??, ye? iiaeooue aooe aeei?enoai? ye aeiiii?aei? oa?aeoa?enoeee i?e a?a??i?/i?e ioe?ioe? ?a/iaei c yaiei aaiie?coth/ei aoaeoii. Nienie iioae?eiaaieo iniiaieo i?aoeue ca oaiith aeena?oaoe?? 1. Nethna?aiei A.A., Aeoaai A.I. Ei??aeyoeey iaaeaeo iauae oiene/iinoueth e iioaioeeaeueiie iooaaaiiinoueth ia i?eia?a enneaaeiaaiey i?ia aiaeu ec Aeiai?ianeiai aiaeii?iaiaea // Aeieeaaeu aeaaeaiee iaoe. - 1998. - ? 11. - N. 187 - 191. 2. Nethna?aiei A.A. Enneaaeiaaiea caeiiiia?iinoae eciee?iaaiiiai aeaenoaey i?ei?eoaoiuo aiaeiuo e aicaeooiuo caa?ycieoaeae ia iiaeaeyo nenoaiu e?iae // I?iaeaie aeieia?/ii? iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??. Ca??iee iaoeiaeo i?aoeue. Aei. 3. - Eoaaine, 1997. - N. 151-155. 3. Nethna?aiei A.A., Aeoaai A.I. Ioeaiea iauae oiene/iinoe e iioaioeeaeueiie iooaaaiiinoe ia i?eia?a enneaaeiaaiee i?ia aiaeu ec Aeiai?ianeiai aiaeii?iaiaea // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. - 1998. - Aei. 19. - N. 100 - 105. 4. Nethna?aiei A.A. Eniieueciaaiea y?eo?ioeeoa?iie iiaeaee aeey aeaeaie/aneie oa?aeoa?enoeee i?ei?eoaoiuo aauanoa-caa?ycieoaeae aiaeu e aicaeooa // Aeaeaia ianaeaiiuo iano. Nai?iee iao/iuo o?oaeia Iao/ii-enneaaeiaaoaeueneiai einoeoooa iauae e eiiioiaeueiie aeaeaiu ei. A.I.Ia?caaaa e Oeaio?a iaaeeoeeineie aaiaoeee. - Eeaa. - 1998. - N.362 - 366. 5. Nethna?aiei A.A., Aeeca?ia A.A. I?iaiice?iaaiea oieneeieiae/aneeo ia?aiao?ia aauanoa ia iniiaa iaoiaea ii?aaeaeaiey nei?inoe aaiieeca y?eo?ioeeoia e iaoaiaoe/aneiai iiaeaee?iaaiey // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. - 1998. -Aei. 19. - N. 105 - 108. 6. Nethna?aiei A.A. E aii?ino i caeiiiia?iinoyo eciee?iaaiiiai aeaenoaey i?ei?eoaoiuo caa?ycieoaeae aiaeiie e aicaeooiie n?aaeu ia iiaeaeyo nenoaiu e?iae // Aaeeoeueeee e?ea?nueeee a?niee. - 1998. - ?1, O. 5.- N. 72 - 75. 7. Nethna?aiei A.A. Ioeaiea iauaoiene/aneiai aeaenoaey aiaeiuo caa?ycieoaeae ia iiaeaeyo nenoaiu e?iae //Aeooaeueiua aii?inu aeaeaiu ie?oaeathuae n?aaeu. Nai?iee iao/iuo o?oaeia Iao/ii-enneaaeiaaoaeueneiai einoeoooa iauae e eiiioiaeueiie aeaeaiu ei. A.I.Ia?caaaa. - Eeaa. - 1995. - N. 150-153. 8. Nethna?aiei A. A. A?ioanooaaiiy caaaeueiioiene/ii? aaciaee ia iiaeaeyo e?ia? // Oace aeiiia?aeae XIII c'?caeo a?a??i?no?a Oe?a?ie "I??i?eoaoi? i?iaeaie a?a??i?/ii? iaoee, iaaee/ii? aeieia??, nai?oa?ii? i?aeoeee oa ioi?iie caei?ia'y". - Ee?a: Aeaaeai?y iaaee/ieo iaoe Oe?a?ie, Iaoeiaa oiaa?enoai a?a??i?no?a Oe?a?ie. - 1995. -N. 190 Nethna?aiei A. A. Aeni?an-ioe?iea o?i?/ieo oaeoi??a aiaeiiai oa iia?o?yiiai na?aaeiaeua ia i?aenoaa? a?eo?ioeeoa?ii? iiaeae?. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 14.02.01 - a?a??ia. - Oe?a?inueeee iaoeiaee a?a??i?/iee oeaio? IIC Oe?a?ie, Ee?a, 1999. Aeena?oaoe?th i?enay/aii ?ic?iaoe? iaoiaee/ieo i?aeoiae?a aei aeei?enoaiiy a?eo?ioeeoa?ii? iiaeae? aeey a?a??i?/iiai ioe?iee aaiioiene/ii? ae?? o?i?/ieo oaeoi??a aiaeiiai oa iia?o?yiiai na?aaeiaeua. O ?iaio? aoei aeei?enoaii oae? iaoiaee: aecia/aiiy eeneioii? ?acenoaioiino? a?eo?ioeeo?a, aecia/aiiy neeaaeo iene-, aeaciene- oa iaoaaiiaeia?io, a oaeiae aeni?an-iaoiae Aeina. ?ic?iaeaii i?aeoiaee aei aaeeaaiiy a?eo?ioeeoa?ii? iiaeae? aeey a?a??i?/iiai ioe?ithaaiiy oaeoi??a ioi/oth/iai na?aaeiaeua (ia i?eeeaae? 19 o?i?/ieo ?a/iaei - aiaeieo oa iia?o?yieo caa?oaeithaa/?a, a oaeiae i?ia aiaee ?. Aei?i?i ia ??cieo aoaiao aiaeii?aeaioiaee oa i?ia aa?icieueii? /anoeie aoiinoa?iiai iia?o?y aeayeeo i?no Oe?a?ie). Cai?iiiiiaaii iaoiaeeeo ?ic?aooieo ia?aiao??a aaiioiene/iino?, yea aeicaiey? aecia/eoe i?i?iaeuei? aaiie?oe/i? eiioeaio?aoe??, ye? iiaeooue aooe aeei?enoai? ye aeiiii?aei? oa?aeoa?enoeee i?e a?a??i?/i?e ioe?ioe? ?a/iaei c yaiei aaiie?coth/ei aoaeoii. Eeth/ia? neiaa: aaiioiene/i?noue, aaiie?c a?eo?ioeeo?a, o?i?/i? oaeoi?e na?aaeiaeua, i?i?iaeuei? aaiie?oe/i? eiioeaio?aoe??. Nethna?aiei A.A. Yeni?ann - ioeaiea oeie/aneeo oaeoi?ia aiaeiie e aicaeooiie n?aaeu ia iniiaa y?eo?ioeeoa?iie iiaeaee. - ?oeiienue. Aeenna?oaoeey ia nieneaiea noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 14.02.01 - aeaeaia. - Oe?aeineee iao/iue aeaeaie/aneee oeaio? IC Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia ?ac?aaioea iaoiaee/aneeo iiaeoiaeia e eniieueciaaieth y?eo?ioeeoa?iie iiaeaee aeey aeaeaie/aneie ioeaiee oiene/aneiai aeaenoaey oeie/aneeo oaeoi?ia aiaeiie e aicaeooiie n?aaeu. A caaea/e enneaaeiaaiey aoiaeeei: 1. Auyaeoue caeiiiia?iinoe eciee?iaaiiiai aeaenoaey (caaeneiinoe "a?aiy -yooaeo", "eiioeaio?aoeey - yooaeo") iaeioi?uo oeie/aneeo oaeoi?ia ie?oaeathuae n?aaeu (i?iaeoeoia oei?e?iaaiey e iciie?iaaiey aiaeu, i?aaie/aneeo ?anoai?eoaeae e nieae oyaeaeuo iaoaeeia) ia aaiioiene/iinoue n eniieueciaaieai y?eo?ioeeoa?iie iiaeaee ?i vitro. 2. Enneaaeiaaoue aaiioiene/iinoue i?ia aiaeiie e aicaeooiie n?aaeu ia iniiaa y?eo?ioeeoa?iie iiaeaee ?n vitro. 3. Niiinoaaeoue ?acoeueoaou nianoaaiiuo enneaaeiaaiee ii aaiioiene/iinoe e iooaaaiiinoe oeie/aneeo oaeoi?ia aiaeiie e aicaeooiie n?aaeu n aeaiiuie ii iauae oiene/iinoe yoeo oaeoi?ia. 4. ?ac?aaioaoue iaoiaeeeo ?an/aoa ia?aiao?ia aaiioiene/iinoe a ea/anoaa aniiiiaaoaeueiuo oa?aeoa?enoee i?e aeaeaie/aneie ioeaiea oeie/aneeo oaeoi?ia ie?oaeathuae n?aaeu. A ?aaioa auee eniieueciaaiu neaaeothuea iaoiaeu: ii?aaeaeaiey eeneioiie ?acenoaioiinoe y?eo?ioeeoia, ii?aaeaeaiey niaea?aeaiey iene-, aeaciene- e iaoaaiiaeiaeia, a oaeaea yeni?ann-iaoiae Yeina. A oanoa Yeina auei eniieueciaaii aeaa oano-ooaiia Salmonella typhymurium OA 98 (auyaeyao iooaaaiu, eiaeooee?othuea iooaoeee ii oeio naeaeaa ?aiee n/eouaaiey aaiaoe/aneiai eiaea) e OA 100 (auyaeyao iooaaaiu, eiaeooee?othuea iooaoeee ii oeio caiaiu ia? iniiaaiee AeIE). Auei i?iaaaeaii 58 na?ee yenia?eiaioia, ec ieo 47 iinayuaii eco/aieth aaiioiene/iinoe e 11- iooaaaiiinoe. Enneaaeiaaii 19 oeie/aneeo aauanoa: aoeaoao naeioea, aaicaeueaeaaeae, aaicie, aeo?iiao eaeey, aooaiie-1, aeae?ioeiii, aeeoei?yoai, iiiioei?oenoniay eeneioa, ieo?ao naeioea, ieo?ao oea?ey, naeaieo iao?ey, oenoniay eeneioa, /aou?aooei?enoue oaea?iae, oaiie, oi?iaeueaeaaeae, oo?oo?ie, oei?aeaeae?ao, oei?eae eaioaia, oei?eae no?iioeey. ?ac?aaioaiu iiaeoiaeu ii i?eiaiaieth y?eo?ioeeoa?iie iiaeaee aeey aeaeaie/aneie ioeaiee oeie/aneeo oaeoi?ia ie?oaeathuae n?aaeu (ia i?eia?a 19 oeie/aneeo aauanoa - aiaeiuo e aicaeooiuo caa?ycieoaeae, a oaeaea i?ia ieoueaaie aiaeu ec Aeiai?ianeiai aiaeii?iaiaea ia ?acee/iuo noaaeeyo aiaeiiiaeaioiaee a ethia 1996 aiaea (enoiaeiay aiaea; oei?e?iaaiea a aeicao 5 ia/e e 10 ia/e aeoeaiiai oei?a; iciie?iaaiea a aeicao 4,25 ia/e e 6 ia/e; eiaaoeyoeey; ionoaeaaiea; oeeueo?aoeey; aoi?e/iia oei?e?iaaiea) e i?ia ay?icieueiie /anoe aoiinoa?iiai aicaeooa iaeioi?uo ai?iaeia Oe?aeiu: Aeiiaoee, Ia?eoiieue, ?iaii, Naaanoiiieue, Naaa?iaeiiaoee, Noiu, ioia?aiiuo a ia?eiae 1992 aiaea). N eniieueciaaieai oanoa Yeina i?iaaaeai aiaeec iooaaaiiinoe auoaoeacaiiuo i?ia aiaeiie e aicaeooiie n?aaeu. Ioia/aia acaeiinaycue ?acoeueoaoia ii eco/aieth aaiioiene/iinoe e iooaaaiiinoe. I?iaaaeai n?aaieoaeueiue ea/anoaaiiue aiaeec iieo/aiiuo ?acoeueoaoia eco/aiey i?ia ieoueaaie aiaeu e aoiinoa?iiai aicaeooa n aeaiiuie Eeaaaiaeieaiaea ii niaea?aeaieth i?aaie/aneeo niaaeeiaiee a enoiaeiie aiaea ?aee Aeiai? ca 1996 aiae e aeaiiuo Oe?aeae?iiaoa 1992-1996 aiaeia ii ea/anoaaiiiio e eiee/anoaaiiiio o?iaith caa?yciaiiinoe enneaaeiaaiiuo ai?iaeia. I?e enneaaeiaaiee eciaiaiey ?acenoaioiinoe y?eo?ioeeoia io ?acee/iuo eiioeaio?aoeee 19 aauanoa auei onoaiiaeaii o?e ?aciuo oeia caaeneiinoae - iiceoeaiue, iaaaoeaiue e iaeo?aeueiue, naycaiiua, aeaeeii, n ?acee/iuie iaoaieciaie aeaenoaey. Oaeaea aeieacaii, /oi i?e oei?e?iaaiee ieoueaaie aiaeu (acyoie ec Eeaaneiai aiaeii?iaiaea a eaoiee ia?eiae 1996 aiaea) a aeica 5 ia/e aeoeaiiai oei?a iieacaoaee aa aaiioiene/iinoe auee iaeneiaeueiuie (aeinoiaa?iia i?aauoaiea eiio?iey a 2 ?aca). O?iaaiue iooaaaiiinoe, ii iieacaoaeyi oanoa Yeina, a 11,5 ?ac i?aauoae eiio?ieue. I?eiaiaiea iciia a ea/anoaa aeaceioaeoaioa oeo/oaei iieacaoaee aaiioiene/iinoe e iioaioeeaeueiie iooaaaiiinoe aiaeu. O?iaaiue aaiioiene/iinoe aiaeu nie?auaeny a 1,5 ?aca e aa iooaaaiiinoue - 3,8 ?aca ii n?aaiaieth n oei?e?iaaieai. I?e enneaaeiaaiee i?ia aoiinoa?iiai aicaeooa 6 ai?iaeia Oe?aeiu (Aeiiaoee, Naaa?iaeiiaoee, ?iaii, Ia?eoiieue, Noiu, Naaanoiiieue) n eniieueciaaieai iaoiaea ii?aaeaeaiey eeneioiie ?acenoaioiinoe y?eo?ioeeoia auyaeaii, /oi iaeaieaa iaaeaaii?eyoiui yaeyaony aoiinoa?iue aicaeoo ai?iaeia Ia?eoiieue (iieacaoaee aaiieeca a 1,4 ?aca i?aauoaee eiio?ieue). Aeiiaoee (a 1,3 ?aca). Naaa?iaeiiaoee (a 1,2 ?aca). Iieacaoaee aaiieeca i?iau ay?icieueiie /anoe aicaeooa ai?iaea Naaanoiiieue i?aeoe/anee niaiaaeaee n eiio?ieueiuie. ?ac?aaioaia iiaeaeue aeeiaieee aaiieeca y?eo?ioeeoia. I?aaeeiaeaia iaoiaeeea ?an/aoa ia?aiao?ia aaiioiene/iinoe, eioi?ay iicaieyao ii?aaeaeeoue ieieiaeueiua aaiieeoe/aneea eiioeaio?aoeee aauanoa-aaiieeoeeia. Yoe eiioeaio?aoeee a ia?niaeoeaa iiaoo auoue eniieueciaaiiuie eae aniiiiaaoaeueiua oa?aeoa?enoeee i?e aeaeaie/aneie ioeaiea yoeo aauanoa. Iao/iay iiaecia ?aaiou caeeth/aaony a onoaiiaeaiee caaeneiinoe «aeica-yooaeo» aeey aaiioiene/aneiai aeaenoaey oeie/aneeo aauanoa ia y?eo?ioeeoa?iie iiaeaee in vitro. Aia?aua onoaiiaeaiu caeiiiia?iinoe aeeyiey oaeeo aauanoa eae oaiie, aoeaoao naeioea e oei?aeaeae?ao ia i?ioeann iaoaaiiaeiaeiia?aciaaiey. Ia iniiaa i?iaaaeaiiuo enneaaeiaaiee e iaoaiaoe/aneiai iiaeaee?iaaiey aia?aua ?ac?aaioaia iaoiaeeea ?an/aoa ia?aiao?ia aaiioiene/iinoe aauanoa, iaeaaeathueo aaiieeoe/aneeie naienoaaie. Ii iaoa?eaeai ?aaiou iioaeeeiaaii 7 noaoae, 1 oacenu e 1 eioi?iaoeeiiiia ienueii. Eeth/aaua neiaa: aaiioiene/iinoue, aaiieec y?eo?ioeeoia, oeie/aneea oaeoi?u n?aaeu, ieieiaeueiua aaiieeoe/aneea eiioeaio?aoeee. Slyusarenko A. V. Express-assessment for chemical factors of water and air environment using erythrocital model. - Manuscript. Thesis for a candidate's degree in biological sciences by speciality 14.02.01 -hygiene. - Ukrainian Scientific Centre of Hygiene of the Ministry of Health of Ukraine, Kyiv, 1999. The dissertation is devoted to the development of methodological approaches to using model erythrocyte for hygienic determination of toxicological action of water and air chemical factors. The follows methods were used: method of determination of acid resistance of erythrocytes, method of contents determination for oxy-, desoxy- and inethemoglobulin and Ames express-method. The approaches are elaborated for model erythrocyte as additional ways for hygienic assessment of surrounding factors (for example 19 chemical substances - water and air contaminators, Dnipro water samples during different stages of water preparation and aerosol part of atmospheric air samples from some Ukrainian sites). Calculated method of hemotoxic parameters has been proposed. This method allows to determine minimal hemolytic concentrations. These parameters would be used as additional characteristics for hygienic assessment ofhemolitical substances . Key words: hemotoxicity, erythrocyte hemolysis, chemical environmental factors, minimal hemolytic concentrations. Aeneiaeth?ii iiaeyeo noa?oiio iaoeiaiio ni?a?ia?oieeo, caa?aeoaa/o eaai?aoi??? a?i?iaeeeaoe?? iooaaai?a Oe?a?inueeiai iaoeiaiai oeaio?o iaaee/ii? aaiaoeee IIC ? IAI Oe?a?ie, eaiaeeaeaoo a?ieia?/ieo iaoe AeOAAIO Ieaen?th Ia?oai'yiiae/o ca eiinoeueoaoeaio oa i?aai?caoe?eio aeiiiiiao i?e aeeiiaii? aeaiiai aeine?aeaeaiiy.

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