2

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

EE?ANUeEEE IAOEIAI-AeINE?AeIEE ?INOEOOO IOIEA?EIAIEIA??

?i. i?io. I.N.EIEII?E*AIEA

Ia i?aaao ?oeiieno

OAOE?ANUeEA IAOAE?ss TH???AIA

OAeE 616-071.3:612.015:616.285-089.844

Aenia?eiaioaeueii-ee?i?/ia iaa?oiooaaiiy canoinoaaiiy aooio?a?eiiai?
eeaeiai? eiiiiceoe?? i?e ?aeiino?oeoeaii-

a?aeiiaieo iia?aoe?yo ia aon?

14.01.19 — ioi?eiiea?eiaieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo?
ioiea?eiaieia?? ?i. i?io. I.N.Eieii?e/aiea, IIC Oe?a?ie (i.Ee?a).

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Nooei TH??e Ieaenaiae?iae/, caa?aeoaa/
a?aeae?eaiiy oeiiaiiieanoeee Ee?anueeiai IAe? ioiea?eiaieia??.

Iaoeiaee eiinoeueoaio:

caneoaeaiee ae?y/ iaoee oa oaoi?ee Oe?a?ie, Eao?aao Aea?aeaaii? i?ai??
Oe?a?ie, aeieoi? a?ieia?/ieo iaoe i?ioani? E.I.Aa?ai??iei

Io?oe?ei? iiiiaioe:

caneoaeaiee ae?y/ iaoee oa oaoi?ee Oe?a?ie, Eao?aao Aea?aeaaii? i?ai??
Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? Aaca?ia Aieiaeeie? A?eai?iae/,
caa?aeoaa/ eaai?aoi??? ee?i?/ii? aoae?ieia?? oa aanoeaoeieia??
Ee?anueeiai IAe? ioiea?eiaieia??;

aeieoi? iaaee/ieo iaoe, i?ioani? Aethi?i Ieaa Aaea??eiae/, caa?aeoaa/
eaoaae?e ioi?eiiea?eiaieia?? Iaeanueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

I?ia?aeia onoaiiaa: Ee?anueea aea?aeaaia iaaee/ia aeaaeai?y
i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea, eaoaae?a ioi?eiiea?eiaieia??, IIC
Oe?a?ie, i.Ee?a.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “___15_”__a?oaeiy 1998 ?. i 14
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.611.01
Ee?anueeiai iaoeiai-aeine?aeiiai ?inoeoooo ioiea?eiaieia?? ?i. i?io.
I.N.Eieii?e/aiea (i.Ee?a, aoe.Ciieia?/ia, 3).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ioiea?eiaieia?? ?i. i?io.
I.N.Eieii?e/aiea.

Aaoi?aoa?ao ?ic?neaii “_12_”_eenoiiaaea_ 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe A.?.?iceeaaeea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue oaie

?aaaieioaoeiy oai?eo c i?eaeoooaaoinoth, yea aeeeeeaia o?iii/iei aiieiei
na?aaeiii ioeoii (OANI), ? nioeiaeueii aaaeeeaith i?iaeaiith. Ianeiaeee
OANI iiaeooue aooe ?icieie: aai o i?ioean caeo/athoueny ani no?oeoo?e
na?aaeiueiai aooa, aai aii iineoue aieueo-iaio iaiaaeaiee oa?aeoa?
(I.A.?aaeiuaiei, A.A.Inueeia, 1979; I.A.I?aia?aaeaineee, I.A.Ieoaiueeei,
1979; TH.A.Nooei, 1980; Feldman, 1977; Dygle, 1977; Lim, Birk, 1977;
Groves, 1979; Fish, 1994).

Aiaeiiaeaiiy c?oeiiaaieo no?oeoo? na?aaeiueiai aooa, neooiai? ooieoei?
i?e OANI oa eiai ianeiaeeao – aeooaeuei? ieoaiiy ioiao?i? (A.N.Naaei,
1981; I.E.Iaoyeeia, 1982; TH.A.Nooei, 1985; A.Ae.Aonaeia, 1986; Frausse
et al., 1985; Lau, Tos, 1987; Plester, 1987; Moszynsky, 1985; Saiki et
al., 1987).

Inoi?e/ii aeey ia?oeo aoaiia ?ic?iaee oaoiiee o??o?a?/ieo ao?o/aiue ia
na?aaeiueiio aoni c i?eaiaeo OANI oa?aeoa?ia oaiaeaioeiy eeoa aei
eieaiaeaoei? aiieiiai ina?aaeeo oa iiia?aaeaeaiiy iioaioeieii?
iiaeeeainoi aioo?ioiuei/a?aiieo oneeaaeiaiue (E.N.THcaeieaae/, 1983;
A.I.Aueiaa, 1985; E.A.Noaeueiao, 1985; Goodhill, 1979; Falsen, 1983;
Rauchjass, 1985), a aeey no/anieo – caa?aaeaiiy aai iie?ioaiiy neooiai?
ooieoei? (O.A.Aiaaeaiiaa, 1980; A.A.Enueeea e niaao., 1981; E.I.Iao?iaa
e niaao., 1983; A.A.Enueeea, 1983; A.A.Neo/aiei, 1986; Ojala et al.,
1982; Schindler, 1983; Ojala et al., 1983; Schwalen, 1986; Pernin et
al., 1987; Palva, 1987; Mulfau, 1987; Hicks, Wright, 1988; Charachon,
1988).

Aeey ooieoeiiiaeueiiai ?acoeueoaoo iia?aoei? aeoaea aaaeeeaei ?
caiiuaiiy c?oeiiaaieo no?oeoo? na?aaeiueiai aooa aiiieanoe/iei
iaoa?iaeii, aeonoe/ii, iaoaii/ii oa aiieiai/ii aeanoeainoi yeiai
iaeaioe/ii aai aeecueei aei i?e?iaeiio (Palva, 1972, 1979; M.Portmann,
1982), a oaeiae iaaeieia oienaoeiy iaoa?iaeo, yeee caiiuo? c?oeiiaaio
no?oeoo?o, c noniaeiiie aiaoiii/ieie ooai?aiiyie (N.E.Iinoiaie,
A.O.Aiy?neee, 1979; Patterson, 1967; Wolf, 1981; Siedentop, 1983).

Aeai? iaoa?iaeia, ye? canoiniaothoueny o
?aeiino?oeoeaii-aiaeiiaethaaeueiie oi?o?ai? na?aaeiueiai aooa, aeineoue
aaeeeee. Oea aooio?ainieaioaoe — oanoeiy, o?yu, noiiea aaie, aee?iaa
oeaieia (Imai, 1984), i’yciaa oeaieia (Strauss, 1984), oei?a (Paris et
al., 1979), einoeiaa oeaieia (Belussi, Passali, 1984; Kirtape, 1984),
neeciaa iaieiiea (E.E.Iioaiia, 1964; TH.A.Nooei, 1964); aeio?ainieaioaoe
— aeaiiia?aeiciaaia einoea (TH.A.Nooei e niaao., 1989), o?yuiaa oeaieia
(A.I.Neoieeia, 1974; Kirtape et al., 1984), iiaoueiaa ieanoeiea
(A.I.Neoieeia, 1974; A.E.?iaeei, 1981); enaiio?ainieaioaoe
(I.A.I?aia?aaeaineee, I.E.Iaoyeeia, 1978, 1982); iiieaioaoe — ?icii
aeaee aiiaeoeaii? oa aiiiia?oii? ea?aiiee (N.I.Oa/eiaoaeee, 1988;
Yamato, 1985), iaoaee oa ?o nieaae (Palva et al., 1980; Yamato, 1980),
ieanoiane oa iieiia?e (TH.A.Nooei, 1981; Kirtape, 1985; Bagot, 1994).

Oienaoeiy o?ainieaioaoia oa iiieaioaoia iiae /an o??o?a?/ieo ao?o/aiue
ia na?aaeiueiio aoni caeienith?oueny ca aeiiiiiaith ianooiieo caniaia:
oe?iiethth/eo oa iiaeo?eioth/eo i?ioacia (Gersdorff et al., 1981, 1983),
ae?ioyieo iii?ieo aeaiaioia oa ea?eania (N.Ae.Aa?aieaeca, 1985; Yamato,
1980), ?a/iaei, ui ?icniieoothoueny (I.Portmann, 1979, 1981; Gersdorff,
1981, 1983), oaiiiiia (Gersdorff, 1983; Hause, 1979). Aea nooo?aei
iaaeieieii aeacaieo iaoa??ae?a ? iaiaoiaeiinoue ?o ianooiiiai aeaeaeaiiy
oa iiaeeeainoue iiai/ii? aei? ?a/iaei, ui ?icniieoothoueny (Wolf, 1983;
Harris, 1993).

Iaeaieueo aoaeoeaiei caniaii, ui aeicaiey? caeienithaaoe iaaeieio
oienaoeith oeaiei oa aeaiaioia o ii?iaeieiao iaaeoi iaeeo ?icii?ia, ?
eeae (Sidentop, Harris, 1985; Epstein et al., 1986; Marquet, 1989). O
?aeiino?oeoeaii-aiaeiiaethaaeueiie oi?o?ai? canoiniaoaaeenue ?icii
eeaeiai eiiiiceoei?: eeae Eieieieueoeaaa (E.ss.?icao, 1958),
oeiaiae?eeaoe (A.ss.Ioaeaaeca, 1990; Coover et al., 1959),
iaoeeiaoae?eeaoe (Braunwald, 1962; N.E.Iinoiaie e niaao., 1970; Ave,
1980). Oe?ieiai ?iciianthaeaeaiiy o aio/eciyiie
?aeiino?oeoeaii-aiaeiiaethaaeueiie oi?o?ai? aiie ia io?eiaee aianeiaeie
nai?o, ae?aaeaieo o ?iciie ii?i, iaaeieieia: oiene/iinoi, aea?aaiiinoi,
caeaoiinoi aeeeeeaoe ?aaeoeaia caiaeaiiy aae aei aiaeoi?aiaiiy oa
iae?ico oeaiei (A.A.Aeoiaaneee, 1976; A.A.Ioaeaaeca, 1990; A.I.Eieioa,
1991).

Nooo?aee ?icaeoie oaoiieiai? eeaeiai? oienaoei? oeaiei iia’ycaiee c
?ic?iaeith oa ai?iaaaeaeaiiyi aiieiai/iiai eeath ia iniiai oia?eiiaaio,
a oaeiae c aea/aiiyi eiai aiieiai/ieo aeanoeainoae (Epstein et al.,
1986).

Iniiaieie ia?aaaaaie aiieiai/ii? aaeaaceaii? eiiiiceoei? ia?aae
oeiaiae?eeaoaie ? oa, ui aiia neeaaea?oueny aeeeth/ii c oiciieiai/ieo
eiiiiiaioia, a i?e neeathaaiii aiaeoai?th?oueny iaoaiici ii?iaeueiiai
cn?aeaiiy e?iai. Ooai?aiiy oia?eiiaeo aieieii ia iiaa?oii ?aie ?
caeeth/iei aoaiii cn?aeaiiy e?iai — ia?aoai?aiiy ?ic/eiiiai aieea ieacie
e?iai oia?eiiaaia o ia?ic/eiiee — oia?ei. Nioea oia?eia neoaeeoue
iao?eenii aeey «a?inoaiiy» oia?iaeanoia i ooai?aiiy oia?ee eieaaaio, ui
ni?ey? iioeiaeueiiio caai?iith ?ai (Kaeser, Dum, 1988). C’?aeioth/ee
oeaieie oia?eiiaee eeae o iiaeaeueoiio cacia? iiaiiai ?icuaieaiiy, i?e
oeueiio ia ooai?ththoueny ?a/iaeie, ni?iiiaei? oeiaeeeai aieeaaoe ia
oeaieie (Yoshida, Hirano, 1989; Vedurg, Ohksen, 1990; Yabe, 1990).

Oei a?eueo, oia?eiiaee eeae, aeaioiaeaiee c e?iai naiiai oai?iai,
aeeeth/a? ?ecee ia?aaea/i ai?onieo (aaiaoeo A, NIIAe) aai aaeoa?iaeueieo
iioaeoeie (E.I.Aa?aiaaiei e niaao., 1990; Luchini et al., 1990; Schwarz,
1991, Weisman et al., 1987).

I?ioa aiaeiii iaoiaeeee io?eiaiiy aooioia?eiiaeo eeaeiaeo eiiiiceoeie oa
?o neeaae iathoue aeayei iaaeieiee:

a) iaiaoiaeiinoue io?eiaiiy aiaeiinii aaeeeeo ia’?iia e?iai a?ae
iaoei?ioa (50-100 ie), ui iaiaaeo? canoinoaaiiy eeath o aeioae oa inia c
ii?ooaiiyie o nenoaii cn?aeaiiy e?iai oa oia?eiieico (Tolnay S. et al.,
1987);

a) iacia/ia eieueeinoue o i?aia?aoao eeath aioei?ioaieioe/ieo oa
aioeoia?eiieioe/ieo ?a/iaei, ui caoeuathoue eiai aiae eiceno
i?ioa?iacaie e?iai oa oeaiei, a oaeiae aiaenooiinoue o ?o neeaaei
aioeaaeoa?iaeueieo oa iioiinoeioethth/eo eiiiiiaioia, ui caaacia/othoue
i?enei?aio ?aia?aoeith oeaiei (Kostening et al., 1986).

a) canoinoaaiiy iie?ia??a o?a?eio, ye? aeioneathoue a?aeii? caei?aeiii?
o??ie, o ?aeiino?oeoeaii-a?aeiiai?e o??o?a?? aeiiii?/ii iaaeioe?eueii a
ca’yceo c ?o aenieith oe?iith.

Aeeeaaeaia aeua i noaei iniiaith aeey i?iaaaeaiiy oei?? ?iaioe.

Ca`ycie c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Aeena?oaoe?y ? neeaaeiaith /anoeiith iaoeiai-aeine?aeii? oaie
Ee?anueeiai IAe? ioiea?eiaieia?? ?i. i?io. I.N.Eieii?e/aiea “?ic?iaeoe
iia? iaoiaee o??o?a?/iiai e?eoaaiiy oai?eo ia o?ii?/iee ai?eiee
na?aaei?e ioeo, ni?yiiaai? ia a?aeiiaeaiiy aiaoii?? oa ooieoe??
na?aaeiueiai aooa” (? aea?ae?a?no?aoe?? A? UA01004163?).

Iaoa ?iaioe. ?ic?iaeoe neeaae oa niin?a io?eiaiiy aooio?a?eiiai?
eeaeiai? eiiiiceoe?? (AOEE), aenia?eiaioaeueii iaa?oiooaaoe ??
canoinoaaiiy i?e ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?yo ia aon? o oai?eo
ia o?ii?/iee ai?eiee na?aaei?e ioeo. Aea/eoe aoaeoeai?noue
cai?iiiiiaaii? aooio?a?eiiai? eeaeiai? eiiiiceoe?? i?e neooia?aeiiaieo
iia?aoe?yo o oai?eo ia OANI.

Caaea/? aeineiaeaeaiiy

1. ?ic?iaeoe iaoiae io?eiaiiy aooio?a?eiiai? eeaeiai? eiiiiceoe??.

2. ?ic?iaeoe niinia noa?eeicaoei? eiiiiiaio?a AOEE.

3. O iiaeaeueieo aeine?aeao aea/eoe iaoaii/io iioeiinoue c’?aeiaiiy
oeaiei AOEE oa aeine?aeeoe ?? aeanoeaino?.

4. A aenia?eiaio? ia oaa?eiao aeineiaeeoe caeaoi?noue eiiiiceoe??
noeioethaaoe ?aia?aoeai? i?ioeane a oeaieiao.

5. Ioe?ieoe ?acoeueoaoe ?aeiino?oeoeaii-aiaeiiaethaaeueieo iia?aoeie ia
aoni ?c canoinoaaiiyi AOEE oa o?a?eiiaiai eeath «Tissucol» o??ie «Immuno
AG» o oai?eo ia OANI.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa noai?aii aooio?a?eiiao eeaeiao eiiiiceoe?th, yea i?noeoue:
o?a?eiiaai, iaea?aeaiee ?c e?ia? oai?iai, o?iia?i, ?ia?a?oi?e i?ioaie?co
? o?a?eiie?co – eiio?eeae, -ai?iieai?iiiao eeneioo, a oaeiae
aioeaaeoa??aeuei? i?aia?aoe oa e?cioeei.

?ic?iaeaii niin?a noa?ee?caoe?? eiiiiiaio?a AOEE oeyoii ?o
-ii?ii?ithaaiiy a aeic? 75 A?, yeee ia aieeaa? ia ?o a?ieia?/i?
aeanoeaino?.

Aia?oa anoaiiaeaia noi?ni?noue iie?ia?o o?a?eio c aioeaaeoa??aeueieie
i?aia?aoaie oa e?cioeeiii.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a

Canoinoaaiiy iaea?aeaii? aooio?a?eiiai? eeaeiai? eiiiiceoe?? aeey
c’?aeiaiiy a?iieanoe/ieo iaoa??ae?a i?e
?aeiino?oeoeaii-a?aeiiaethaaeueieo iia?aoe?yo ia aon? o oai?eo ia OANI
ciaioo? ?ecee i?neyiia?aoe?eieo oneeaaeiaiue, aeicaiey? a?aeiiaeoeny
a?ae o?aaeeoe?eii? oaiiiiaaee neooiaiai i?ioiaeo, caaacia/o? a?eueo
no?ee? ii?oieia?/i? oa ooieoe?iiaeuei? ?acoeueoaoe, ciaioo? oa?i?i
ia?aaoaaiiy oai?iai a noaoe?iia?? o na?aaeiueiio ia 4,5 – 5 aei?a.

Ai?iaaaeaeaiiy o i?aeoeeo

Noai?aii aooio?a?eiiao eeaeiao eiiiiceoe?th aeey
?aeiino?oeoeaii-a?aeiiaethaaeueieo iia?aoe?e ia aon? (iaoaio ?in?? ?
2030187 ca 1995 ?.). ?ic?iaeaii iiaee iaoiae
?aeiino?oeoeaii-a?aeiiaethaaeueieo iia?aoe?e ia aon? (iaoaio Oe?a?ie ?
94128300 ca 1997 ?.). ?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeaii a
ee?i?/io i?aeoeeo Ee?anueeiai IAe? ioiea?eiaieia??, eaoaae?e
ioiea?eiaieia?? Ee?anueei? aea?aeaaii? iaaee/ii? aeaaeai??
i?neyaeeieiiii? ina?oe, eaoaae? ioiea?eiaieia?? oaeoeueoao?a i?aeaeuaiiy
eaae?o?eaoe?? e?ea??a Aeiiaoeueeiai iaaee/iiai ?inoeoooo oa Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo..

Iniaenoee aianie caeiaoaa/a

Ee?i?/iee iaeyae, a?aea?? oai?eo, aecia/aiiy ooieoe?iiaeueiiai noaio
neooiai? o?oae, a oaeiae aoae?ieia?/io oa?aeoa?enoeeo oai?eo, o??o?a?/i?
ao?o/aiiy o oai?eo ia o?ii?/iee ai?eiee na?aaei?e ioeo aaoi? i?iaiaeeea
naiino?eii o a?aeae?eaii? oeiiaiiieanoeee Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ioiea?eiaieia?? ?i. I.N.Eieii?e/aiea.

Aaoi?ii ni?eueii c? ni?a?ia?oieeaie eaai?aoi??? a?io?i?? EIAe?
ioiea?eiaieia?? ?ic?iaeaia iaoiaeeea io?eiaiiy oa neeaae aooio?a?eiiai?
eeaeiai? eiiiiceoe??. Aaoi? iniaenoi o eaai?aoi?ieo aeine?aeaeaiiyo
aea/eea aaeaaceai? aeanoeaino? eiiiiceoe?? i?e c’?aeiaii? ??cieo oei?a
a?iieanoe/ieo iaoa??ae?a, ui aeei?enoiaothoueny a
?aeiino?oeoeaii-a?aeiiai?e o??o?a?? aooa. Aaoi?ii iniaenoi ?ic?iaeaia
iaoiaeeea noa?ee?caoe?? eiiiiiaio?a AOEE.

I?e?ia?ieia?/i? aeanoeaino? eiiiiceoe?? aea/aeeny ni?eueii c?
ni?a?ia?oieeaie eaai?aoi??? i?e?ia?ieia?? EIAe? ioiea?eiaieia??.

A?noieia?/i? aeine?aeaeaiiy ii aea/aiith ?aia?aoeaieo i?ioean?a i?e
oeiiaiiieanoeoe? oanoe?aeueiei eeaioai ?c canoinoaaiiyi AOEE a
aenia?eiaio? ia e?ieyo i?iaiaeeeeny ni?eueii c ni?a?ia?oieeaie eaoaae?e
a?noieia?? oa aia??ieia?? Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.
I.I.Aiaiiieueoey. I?e oeueiio aaoi?ii naiino?eii i?iaiaeeeeny iia?aoeai?
ao?o/aiiy ia i?aeaeine?aeieo oaa?eiao.

Aeena?oaioea iniaenoi i?iaaea noaoenoe/iee aiae?c io?eiaieo
?acoeueoao?a, iaienaea an? ?icae?ee aeena?oaoe??, noi?ioethaaea aeniiaee
? i?aeoe/i? ?aeiiaiaeaoe??.

Aaoi?ii iniaenoi ?ic?iaeaia iaoiaeeea canoinoaaiiy aooio?a?eiiai?
eeaeiai? eiiiiceoe?? i?e ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?yo ia aon? o
oai?eo ia OANI oa iieacaia ?? aoaeoeai?noue.

Ai?iaaoeiy ?acoeueoao?a aeena?oaoe??

Iaoa?iaee aeena?oaoeieii? ?iaioe aeiiiaiaeaeenue oa iaaiai?thaaeenue ia
iaoeiaeo eiioa?aioeiyo Ee?anueeiai IAeI ioiea?eiaieiai? IIC Oe?a?ie
(i.Ee?a, 1990, 1992, 1993, 1994, 1995, 1996, 1998 ??.), ia thaieaeiie
iaoeiai-i?aeoe/iie eiioa?aioei? «Nia?aiaiiua i?iaeaiu
ioi?eiiea?eiaieiaee», i?enay/aiie 95-?i//th oa 100-??//th c aeiy
ia?iaeaeaiiy i?ioani?a I.N.Eieii?e/aiea (i.Ee?a, 1993, 1998), ia
can?aeaii? Politzer Society, Punta-Ala (Italy, 1995); Congress
International en O.R.L., A?thnnaeue, 1997.

Ai?iaaoe?eiee caoeno aeena?oaoe?? a?aeaoany 8 n?/iy 1998 ?ieo ia
can?aeaii? i?iaeaiii? eii?n?? “O?c?ieia?y ? iaoieia?y i?aaio neooa oa
aanoeaoey?iiai aia?aoo” Ee?anueeiai IAe? ioiea?eiaieia?? ?i. i?io.
I.N.Eieii?e/aiea.

Ioae?eaoe??

Ca oaiith aeena?oaoe?? iioae?eiaaii 6 aeo?iaeueieo ?ia?o ? 3 – a ca??eao
iaoeiaeo i?aoeue, io?eiaii 2 iaoaioe (iaoaio ?in?? oa iaoaio Oe?a?ie).

Ia’?i oa no?oeoo?a ?iaioe

Aeena?oaoe?y aeeeaaeaia ia 175 noi??ieao ae?oeiaaiiai oaenoo,
neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, /ioe?ueio ?icae?e?a aeanieo
niinoa?aaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e,
iieaae/eea e?oa?aoo?e, yeee iae?/o? 315 aeaea?ae, c ieo 129 – ?iicaiieo
aaoi??a. ?iaioa ?ethno?iaaia 21 oaaeeoeath ? 32 iaethieaie.

CIINO ?IAIOE

Iaoa?iaee i iaoiaee aeineiaeaeaiiy

Oey ?iaioa ? ?acoeueoaoii aenia?eiaioaeueiiai oa ee?i?/iiai
aeine?aeaeaiiy.

O?a?eiiaai – iniiaiee eiiiiiaio AOEE, iaea?aeoaaee c ieacie e?ia? oai?eo
ca?aeii c ?ic?iaeaieie iaoiaeaie a eaai?aoi??? a?io?i?? (E.I.Aa?ai??iei
? ni?aaao., 1991). A ?iaio? aeei?enoiaoaaee o?iia?i – i?aia?ao
Eaoianueeiai i?aei?e?inoaa ii ae?iaieoeoao aaeoa??aeueieo i?aia?ao?a;
?ia?a?oi? i?ioaie?co – eiio?eeae (o??ie VEB (I?ia//eia));
-ai?iieai?iiiaa eeneioa (-AEE) a?o/eciyiiai ae?iaieoeoaa; e?cioeei
Ieaeinueeiai ae?iaieoeoaa (Eeoaa); aioea?ioeee: ea?aai?oeee?i,
aii?oeee?i, aaioai?oeei, iie?i?enei – a?o/eciyiiai ae?iaieoeoaa. Ai?no
o?a?eiiaaio a ieaci? e?ia? oa i?aia?aoao aecia/aee niaeo?ioioiiao?e/iei
iaoiaeii ca A.A.Aae?oea?ii oa ni?aaao. (1983). Eiioeaio?aoe?th
o?a?iiaeoeio aecia/aee ?ioiioa?iaioiei iaoiaeii (Coevin, 1985);
e?euee?nia aecia/aiiy XIII oaeoi?a i?iaiaeeee ?aae?i?ioiieia?/iei
iaoiaeii (Lazard et al., 1972).

I?e?ia?ieia?/i? aeine?aeaeaiiy iieyaaee o aecia/aii? aeaeiaiai neeaaeo
i?e?ioei?e na?aaeiueiai aooa ca iaoiaeeeith N.I.Iaaaoeia, I.E.Oii?ii?
(1992). ?aeaioeo?eaoe?th noao?eieie?a i?iaiaeeee ca ii?oieia?/ieie,
oeieoi??aeueieie, eoeueoo?aeueieie oa a?io?i?/ieie aeanoeainoyie.
?aeaioeo?eaoe?th a?aiiaaaoeaieo aaeoa??e i?iaiaeeee ca eoeueoo?aeueieie
oa a?io?i?/ieie aeanoeainoyie ca?aeii aecia/ieeai Aa?a? (A.E.Iie?ianeee,
1985). Aecia/aiiy /ooeeaino? caoaeieea aei aioea?ioee?a aeeiioaaee ca
iaoiaeeeith N.I.Iaaaoeia oa I.E.Oii?ii? (1982) ca aeiiiiiaith
iine?aeiaieo na??eieo ?icaaaeaiue i?aia?ao?a o aeeaeeueieo eoeueoo?ao.
Ca i?i?iaeueio eiioeaio?aoe?th i?eai?/aiiy (IEI) i?eeiaee iaeiaioo
aeico, o i?enooiino? yei? ia a?aei?/aeiny ?inoo i?e?ii?aai?ci?a.
I?i?iaeueio eiioeaio?aoe?th aioea?ioee?a anoaiiaethaaee oeyoii
ia?an?aaiiy i?e a?aenooiino? aeaeeiiai ?inoo ia oaa?aeeo aeeaeeueieo
eoeueoo?ao. Iai?ae?euee?nia aecia/aiiy /ooeeaino? iocaeieo oa
na?aeaaeae?eaieo ooai?a caoaeiee?a ai?eieo caiaeaiue aooa aei
aioea?ioee?a i?iaiaeeee ca aeiiiiiaith iaia?iaeo aeene?a. A caeaaeiino?
a?ae ae?aiao?o ciie i?eai?/aiiy ?inoo i?e?ii?aai?ci?a iaaeiei aeene?a ?o
iiae?eyee ia /ooeea?, iii??ii /ooeea? oa no?ee?.

Iaoiaeeea aecia/aiiy aioei?e?iaii? aeoeaiino? AOEE a?oioo?oueny ia
aeanoeaino? aioea?ioee?a aeeooiaeoaaoe o aaa?, ca?aaeaiee oano-i?e?iaii.
Aonoioo i?e?iaii? caa?neie aecia/aee ca iioe/iei noaiaea?oii iooiino? ia
5 IAe c iine?aeiaieie ?icaaaeaiiyie a?ae 10-3 aei 10-4 i?e?iaieo ee?oei
a 1 ie. Aeei?enoiaoaaee aeaa oa?e aaa?o. I?ney canoeaaiiy ae?oaiai oa?o
aaa?o ia eiai iiaa?oith ca aeiiiiiaith o?aoa?aoo, ?ici?uaiiio i?ae aeiii
/aoee Iao??, anoaiiaethaaee noa?eeuei? neeyi? oeee?iae?e ae?aiao?ii 0,6
ni ? aenioith 0,7 ni oae, uia aiie eeoa oi?eaeeny aaa?o. Aeeaaeaee 4
oeee?iae?e ia eiaeio /aoeo. Ia?oee i?noea aooio?a?eiiaee eeae c
aioea?ioeeii, ae?oaee – e?cioeei ? aooio?a?eiiaee eeae, o?ao?e –
aooio?a?eiiaee eeae, /aoaa?oee – AOEE c on?ia eiiiiiaioaie. ?icaaaeaiiy
aioea?ioee?a aoei oaeei: ea?aai?oeee?i – 25 iea/ie, aaioai?oeei – 10
iea/ie, iie?i?enei – 300 IAe, aii?oeee?i – 10 iea/ie; ?icaaaeaiiy
e?cioeeio – 0,2 a/ie.

Aecia/aiiy i?ieiiaiaaii? ae?? aioea?ioee?a o neeaae? eiiiiceoe?? aoei
oaeiae caniiaaii ia iinooiia?e aeeooc?? aioea?ioee?a ? e?cioeeio c
iie?ia?ii? iao?eoe? o?a?eio o aeeaeeueia na?aaeiaeua, ca?aaeaia
oano-i?e?iaaie.

Iaoiaeeea aecia/aiiy iaoai?/ii? i?oeiino? c’?aeiaiiy a?iieanoe/ieo
iaoa??ae?a aeeiiaia ia eaai?aoi?i?e onoaiiaoe? ca noaiith,
cai?iiiiiaaiith Siedentop et al. (1985). Aeine?aeaeoaaee aaeaaceai?
aeanoeaino? aooio?a?eiiai? eeaeiai? eiiiiceoe?? c oaeeie a?iieanoe/ieie
iaoa??aeaie: e?noea, oe??a, i’yciaa oeaieia, i’yciaa oanoe?y, ieiuath 1
ni2, io?eiaieo o aenia?eiaioaeueieo oaa?ei – e?ie?a ii?iaee “Oeioeea”.
Iaaeo i?oeiino? aeine?aeaeoaaee ia 5, 15 oa 60 oaeeeiao ? ?ic?aoiaoaaee
ca I.N.Iaeniaei (1971).

Oeiiaiiieanoeeo a aenia?eiaio? aeeiioaaee ia e?ieyo ii?iaee “Oeioeea”
i?ae aioo??oiuei/a?aaiei o?iiaioaeiaei cia/oeaiiyi ca iaoiaeeeith
I.A.?aaeiuaiei (1963), yea iieyaaea o noai?aii? iiaeae? oeiiaiiieanoeee
I oeio ca O.Aoeueooaeiii (1972). Aenia?eiaioaeuei? aeine?aeaeaiiy
aeeiiai? ia 22 e?ieyo. Oaa?eie aeaiaeeeeny c aenia?eiaioo ia 3, 7, 15,
30, 60 aeiao i?ney iia?aoe??. On? i?e?ia?noieia?/i? aeine?aeaeaiiy
i?iaaaeai? o Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?i. aeaae.
I.I.Aiaiiieueoey IIC Oe?a?ie, ia eaoaae?? a?noieia?? oa aia??ieia?? ca
o/anoth i?io. TH.I.*aeeianueeiai oa anenoaioa I.I.A?aaiaiai.

Aeey aeyaeaiiy o?a?eio a i?noeyo neeathaaiiy c??ce oa?aoaaee
oinoi?ii-aieueo?aiiaei aaiaoienee?iii ca iaoiaeii Iaei??. Aeey aea/aiiy
i?ioean?a a?aeiiaeaiiy niieo/iioeaieiii? iniiae aa?aaaiii? ia?aoeiee
aoea aeei?enoaia iaoiaeeea oa?aoaaiiy ca Aai A?cii oa Novelli (1979).

Iaoa??aeii aeey i?e?ia?noieia?/ieo aeine?aeaeaiue aoee o?aaiaioe, ui
aeeth/aee aeaiaioe ciai?oiueiai oa na?aaeiueiai aooa. E?noeia? aeiee
o?enoaaee o 10 % ?ic/ei? oi?iae?io ?c ai?noii 3 % ae?iaoeenoeueoieneaeo
ai?iaeiaae aeiae. I?ney oeueiai aiie aoee aeaeaeueoeeiiaai? o 5% ?ic/ei?
aeeiao???ai? nie? aoai?iia?ai?ioao?aioeoiai? eeneioe ia i?ioyc? 10
aei?a. O?aaiaioe, ui aeeth/aee aa?aaaiio ii?iaeieio, aa?aaaiio ia?aoeieo
oa neooiaee i?io?ae, caeeaaee o ia?ao?i. Na??? c??c?a caaoiaoee 8 iei
i?iaiaeeee /a?ac na?aaei? aooi ia?iaiaeeeoey?ii aa?aaaii?e ia?aoeioe?,
oa?aoaaee aaiaoienee?iii oa aiceiii, a oaeiae aco?-II aiceiii ca
Iaeneiiaei.

Ee?i?/i? aeine?aeaeaiiy i?iaaaeai? i?e ianoaaeaii? oa iia?aoeaiiio
e?eoaaii? 164 oai?eo ia OANI (70 iaoe??io?a /ieia?/i? noao? oa 94 –
ae?ii/i?). Oai?? aoee iiae?eai? ia 3 ee?i?/i? a?oie. 1-a a?oia
(eiio?ieueia) – 60 iaoe??io?a, yeei aoea aeeiiaia i???iaiieanoeea ? I
oei oeiiaiiieanoeee, a oaeiae II aoai oa IV oei oeiiaiiieanoeee ca
o?aaeeoe?eieie iaoiaeeeaie. O 2-o a?oio oa?eoee 55 in?a, yeei aoee
aeeiiai? aeuacaaaeai? oeie oeiiaiiieanoeee ?c canoinoaaiiyi aeey
c’?aeiaiiy o?ainieaioao?a AOEE. O 3-th a?oio oa?eoee 49 oai?eo ?c
iaeiioeiiaeie iia?aoe?yie, yeei aeey c’?aeiaiiy o?ainieaioao?a aoa
canoiniaaiee o??iiaee i?aia?ao “Tissucol” aano??enueei? o??ie “IMMUNO
AG”.

Ianoaaeaiiy oa e?eoaaiiy oai?eo ia OANI i?iaiaeeeinue o a?aeae?eaii?
oeiiaiiieanoeee Ee?anueeiai IAe? ioiea?eiaieia?? ?i. i?io.
I.N.Eieii?e/aiea. A ?iaio? ie ei?enooaaeeny oaeeie iaoiaeaie ee?i?/iiai
ianoaaeaiiy oai?eo: aoae?ieia?/ia ianoaaeaiiy, yea neeaaeaeiny c
aecia/aiiy ni?eeiyooy oai?oii? (OI) oa ?iciiaii? (?I) iiae,
eaia?oiiaeueiiai (i?iae Aaaa?a, ??ia, A?iaa, Oaaea??/a) oa
aoae?iiao?e/iiai aeine?aeaeaiiy. Oiiaeueia ii?iaiaa oa iaaeii?iaiaa
aoae?iiao??y i?iaiaeeeany o caoei?cieueiaai?e eaia?? ia aia?ao? IA-31
(I?ia//eia). Ia iiai?e aoae?ia?ai? o?enoaaeenue ??ai? 100 %
?ica??eeaino? iiaiiai oanoo oa 50 % ?ica??eeaino? /eneiaiai oanoo. ?c
iaaeii?iaiaeo iaoiae?a aeei?enoiaoaaee aecia/aiiy ??aiy aeeneiioi?oo ii
an?e oiiaeuei?e oeae? oa aeeoa?aioe?ei? ii?iae neee caoeo ca iaoiaeii
Ethoa?a aeey /anoio 500 oa 2000 Aoe.

Ooieoe?iiaeuei? ?acoeueoaoe ?aeiino?oeoeaii-a?aeiiaethaaeueieo iia?aoe?e
ioe?ithaaeenue ca i?e?inoii neooo ii iia?o?yi?e i?ia?aeiino? ia 5
iniiaieo iiaieo /anoioao, a oaeiae ca aaee/eiith caeeoeiaiai
e?noeiai-iia?o?yiiai ?ioa?aaeo o oaeiio ae /anoioiiio ae?aiacii?.
??aaiue nioe?aeueii-aaeaeaaoiiai neooo aecia/aee ca iaoiaeeeith
A.A.Aaca?iaa, A.?.?iceeaaeee (1989). Ee?i?/ia oa ooieoe?iiaeueia ioe?iea
aoaeoeaiino? iia?aoe?e i?iaiaeeeany aaciina?aaeiuei i?e aeienoe? oai?iai
?c a?aeae?eaiiy, a oaeiae o oa?i?ie a?ae 6 i?nyoe?a aei 1,5 ?ie?a. I?e
ioineii?? oa ioii?e?ineii?? aei iia?aoe?? caa?oaee oaaao ia noai oe??e
no?iie neooiaiai i?ioiaeo, iayai?noue oa oa?aeoa? aeae?eaiue, noai
neeciai? iaieiiee aa?aaaiii? ii?iaeieie, ai?aea?i?caoe?th ?? no?iie.
E?euee?nio ioe?ieo aaioeeyoe?eii? ooieoe?? neooiai? o?oae i?iaiaeeee ca
iaoiaeii I?eea?a oa N?aeaioiia o iiaeeo?eaoe?? TH.I.Nooei oa
TH.A.?oaeaiei (1976). I?io?aei?noue neooiai? o?oae aecia/aee ca iaoiaeii
A.A.Aiy/aea ?c canoinoaaiiyi i?ia Oieia?, Aaeuenaeueae, Iie?ooea?a oa
eaoaoa?ecaoe?? neooiai? o?oae.

Aeey noaoenoe/ii? ia?iaee ?acoeueoao?a aeine?aeaeaiue aoee canoiniaai?
iaoiaee aa??aoe?eii? noaoenoeee, ye? aeathoue iiaeeea?noue aeyaeoe
caeiiii??iino?, ui eaaeaoue a iniia? aeine?aeaeoaaieo yaeu. Aeey oeueiai
?ic?aoiaoaaeenue na?aaeiueia?eoiaoe/i? iieacieee (M) oa ?o iioeaee (m)
ca aeiiiiiaith ia?niiaeueiiai eiiiuethoa?a o??ie IBM (NOA).
Aeinoia??i?noue ioe?ithaaeany ca eiao?oe??ioii aeinoia??iino? ??cieoe?
(t) oa oaaeeoeath e?eoa??th Nouethaeaioa.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy

I. ?ic?iaea iaoiaeeee iaea?aeaiiy AOEE oa ?? aenia?eiaioaeueia

iaa?oiooaaiiy

Ia?oee aoai ?iaioe iieyaaa o ?ic?iaoe? i?inoiai iaoiaeo aeae?eaiiy
iniiaiiai eiiiiiaioa o?a?eiiai? eiiiiceoe?? – o?a?eiiaaio ?c iaaaeeeeo
ia’?i?a ieacie e?ia? oai?eo. 18 ie e?ia?, yeo a?aee ?c eieoaai? aaie,
iaeeaaee o iie?aoeeaiiao i?ia??eo, yea i?noeea 2 ie aioeeiaaoeyioa –
3,8% ?ic/ei oeeo?aoo iao??th, oaeaeei ia?ai?ooaaee, i?ney oeueiai
oeaio?eooaoaaee 15 oa i?e 3000 ia/oa. Aei iaea?aeaii? (8-10 ie) ieacie
aeiaeaaaee ii e?aieyi iie?aoeeaiae?eieue-6000, e?ioeaaa eiioeaio?aoe?y –
4,6 %. Noniaic?th aeo?eioaaee i?e oaiia?aoo?? 20-230 N i?ioyaii
30 oa, i?ney oeueiai oeaio?eooaoaaee 15 oa i?e 3000 ia/oa.

Inaae, yeee i?noea o?a?eiiaai, ?ic/eiyee a 0,25-0,5 ie 0,06 I oeeo?aoa
iao??th (caeaaeii a?ae ai?noo o?a?eiiaaio). A na?aaeiueiio ai?no
o?a?eiiaaio neeaaeaa 15-30 ia a i?ia?. Iaea?aeaiee i?aia?ao o?a?eiiaai
i?noea XIII oaeoi? cn?aeaiiy e?ia?, yeee caaacia/oaaa ooai?aiiy i?oeii
“i?ioeoiai“ caonoeo o?a?eio. Eiai e?euee?noue eieeaaeany a?ae 6,6o10-3
aei 1,4o10-2 Iiieue ioo?anoeeio/1 oa/ie. A i?aia?ao? o?a?eiiaaio
ciaoiaeeoueny oaeiae o?a?iiaeoei – a?eie, yeee noeioeth? aaeaac?th
o?a?iaeano?a aei o?a?eio. Eiai ??aaiue a ??cieo i?aia?aoao eieeaaany
a?ae 150 aei 400 iea/ie.

O?a?eiiaai aoa ia?oei eiiiiiaioii AOEE. Ae?oaee – a?eeiaee eiiiiiaio
AOEE – o?iia?i c aeoeai?noth 50 NIH iaeeieoeue. Eiai ?ic/eiyee a 0,5 ie
0,44 % ?ic/eio CaCl2.

Aei neeaaeo AOEE aeeth/aee oaeiae iie?ooieoe?iiaeueiee ?ia?a?oi?
Eoi?ooea – eiio?eeae, neioaoe/iee ?ia?a?oi? o?a?eiie?co, -AEE,
aioea?ioee oa oaeoi? ianiaoeeo?/iiai ?ioi?oaoo – e?cioeei.

A ?ic?iaeai?e eiiiiceoe?? ni?aa?aeiioaiiy eiiiiiaio?a (a) neeaaeaei:

o?a?eiiaai — 0,015 – 0,030

o?iia?i, NIH iae. — 50 – 100

eiio?eeae (KIE) — 200 – 400

-AEE — 0,02 – 0,04

aioea?ioee (ea?aai?oeee?i) — 0,02 – 0,04

e?cioeei — 0,02 – 0,04.

Ia?oee eiiiiiaio eeaeiai? eiiiiceoe?? neeaaeaany c o?a?eiiaaio +
eiio??eae + -AEE + aioea?ioee + e?cioeei. Ae?oaee eiiiiiaio – o?iia?i +
CaCl2.

A niaoe?aeuei?e na??? aeine?ae?a aoei aeiaaaeaii, ui ii?aeiaiiy an?o
eiiiiiaio?a ia aieeaa? ia ooieoe?iiaeuei? aeanoeaino? o?a?eiiaaia ?
o?iia?ia.

Aooiaaiiee o?a?eiiaai ia oiio /e ?ioiio aoai? aeae?eaiiy, ia aeeaey/enue
ia noa?eeuei? oiiae, iiaea aooe ?io?eiaaiei ?c ciai?oiueiai na?aaeiaeua.
Noa?eeuei?noue o?iia?io aeey i?noeaaiai canoinoaaiiy ia aa?aioo?oueny
i?iieneiaei ?aaeaiaioii.

A?aoiaoth/e, ui aeai? i?aia?aoe ? oa?iieaa?eueieie aenieiiieaeoey?ieie
a?eeaie, ie ?ic?iaeee iaoiae noa?ee?caoe??
-ii?ii?iaiiyi a?eeiaeo eiiiiiaio?a AOEE.

Iaoiaeeea noa?ee?caoe?? AOEE iieyaaea o i?aeai?? iioeiaeueii? aeice
-ii?ii?iaiiy. Noa?ee?caoe?y eiiiiceoe?? i?iaiaeeeany ca iaoiaeeeith
I.TH.Oaoe?anueei? oa ni?aaao. (1993) ia oaeaaaiaoa?aiaaoe/iiio aia?ao?
“AAAO-?” c aeaea?aeii Ni60.

Ioe?ieo aoaeoeaiino? noa?ee?caoe?? i?iaiaeeee ca aeiiiiiaith
aaeoa??ieia?/iiai iaoiaeo. I?ney ii?ii?iaiiy ia’?eoo aeine?aeaeaiiy
aeicaie 15 oa 30 A? ia i?ioyc? 10 oa 15 oa aen?aaeany nii?iaa iaee/ea.
I?e i?aeaeuaii? aeice a?eueo 45 A? ?inoo i?e?ii?aai?ci?a ia a?aei?/aee.
Aeey a?eueoi? iaaiino? noa?ee?caoe? AOEE ie ia?aee aeico -ii?ii?iaiiy 75
A? c aeniiceoe??th 25 oa.

I?ney noa?ee?caoe?? eiiiiceoe?? iaiao?aeii aoei ioe?ieoe ia o?eueee
aoaeo noa?ee?caoe??, aea e aieea -ii?ii?iaiiy ia a?io?i?/i? aeanoeaino?
eiiiiceoe??, eiie?aoii ia aeanoeaino? o?a?eiiaaio oa o?iia?ia. Ie
aea/aee oaeaee?noue cn?aeaiiy o?a?eiiaaia oa o?iia?ia i?ney
-ii?ii?iaiiy, a oaeiae aieea ??cieo aeic -ii?ii?iaiiy ia ai?no
cn?aea?iiai o?a?eiiaaio. O iaoeo aeine?aeao oaeaee?noue cai?oaiiy
o?a?eiiaaio o?iia?iii i?ney -ii?ii?iaiiy ia ci?ieeany ?
noaiiaeea: eiio?ieue — 10, 10, 10, 15, 15 n, i?ney ii?ii?iaiiy aeicith
75 A? – 10, 10, 11, 14, 15 n (p > 0,05). Ai?no o?a?eiiaaio i?ney
ii?ii?iaiiy oaeiae nooo?ai ia a?ae??ciyany a?ae eiio?ieth: 20, 22, 24,
24 22 ia – o aeine?aeao oa 20, 22, 26, 23, 20 ia – o eiio?ie? (p >
0,05).

Aaaaeaiiy aioea?ioee?a ? e?cioeeio o iie?ii?oio iao?eoeth o?a?eio iiaei
ci?ieoe aioeaaeoa??aeuei? aeanoeaino? aeacaieo i?aia?ao?a. Ie aea/eee
aeoeai?noue aioea?ioee?a ? e?cioeeia o neeaae? eiiiiceoe??.

Ioe?ithth/? i?ioei?e?iaio aeoeai?noue aioea?ioee?a oa e?cioeeia ca
ae?aiao?ii cii cao?eiee ?inoo oano-i?e?ia?a, ie anoaiiaeee, ui aiia
i?aeoe/ii ia a?ae??ciy?oueny a?ae aeoeaiino? oeeo i?aia?ao?a o neeaae?
iie?ia?a o?a?eio. Ae?aiao? cii cao?eiee ?inoo S.aureus noaiiaea aeey
e?cioeeio 10,0 0,3 ii, ea?aai?oeee?io – 17,0 0,5 ii, aaioai?oeeio –
20,0 0,3 ii, a aeey oeeo aea i?aia?ao?a o neeaae? eiiiiceoe?? –
10,0 0,2 ii; 18,0 0,2 ii; 21,0 0,3 ii a?aeiia?aeii (p > 0,05).

Aaaaeaiiy e?cioeeio i?aeaeueei i?ioei?e?iaio aeoeai?noue aioea?ioee?a o
neeaae? eiiiiceoe??. Oae, ae?aiao? ciie cao?eiee ?inoo cieioenoiai
noao?eieieo e?cioeeiii noaiiaea 10,0 0,3 ii, aaioai?oeeiii – 20,0 0,3
ii, iie?ia?ii o?a?eio ? e?cioeeiii – 10,0 0,2 ii, iie?ia?ii o?a?eio ?
aaioai?oeeiii – 21,0 0,3 ii, iie?ia?ii o?a?eio, e?cioeeiii oa
aaioai?oeeiii – 25,0 0,5 ii.

Cai?ii? eiiiiiaioe eiiiiceoe?? (e?cioeei, aioea?ioeee) i?ney neeathaaiiy
ciaoiaeyoueny o iie?ia?i?e iao?eoe? o?a?eio, iiaie? aeeooiaeothoue o
ioi/oth/a na?aaeiaeua, i?iyaeyth/e aioeaaeoa??aeueio oa i?ioecaiaeueio
ae?th. Oaeei /eiii, eeaeiaee oa? ? aeaii e?ea?nueeeo i?aia?ao?a.
Iinooiiaa aeeooc?y aaioai?oeeio ? e?cioeeio ?c iie?ia?ii? iao?eoe?
o?a?eio caaacia/o? a?aenooi?noue ?inoo oano-i?e?ia?a (S.aureus, E.coli,
P.aeruginosa) ia i?ioyc? 10 aei?a. I?e canoinoaaii? ea?aai?oeee?io ?
e?cioeeio ia aeyaeaii ?inoo S.aureus ia i?ioyc? 10 aei?a, E.coli – ia
i?ioyc? 9 aei?a, P.aeruginosa – ia i?ioyc? 7 aei?a. Oaeei /eiii, AOEE
i?ney neeathaaiiy iiaea i?aeo?eioaaoe oa?aiaaoe/io eiioeaio?aoe?th
aioeaaeoa??aeueieo i?aia?ao?a ia i?ioyc? 7-10 aei?a.

Iaeiei ?c ?icae?e?a iaoi? ?iaioe aoei aea/aiiy aaeaaceaieo aeanoeainoae
eiiiiceoe?? c ??cieie a?iieanoe/ieie iaoa??aeaie o ii??aiyii? ?c
o?a?eiiaei eea?i «Tissucol», a oaeiae i?ney -ii?ii?iaiiy eiiiiceoe?? a
aeic? 75 A?.

I?iaaaeai? aenia?eiaioe na?ae/aoue, ui i?oei?noue c’?aeiaiiy aeaio
o?aaiaio?a oanoe?aeueii? oeaieie AOEE, yeo aoei oa ia aoei ii?ii?iaii,
nooo?ai ia a?ae??ciythoueny ? noaiiaeyoue: aei noa?ee?caoe?? ca 5 oa –
15,0 3,0 I/ni2; 15 oa – 75,0 2,5 I/ni2; 60 oa – 230,0 1,5 I/ni2;
i?ney noa?ee?caoe?? – 13,2 2,5 I/ni2; 70,0 3,0 I/ni2; 220,0 1,0 I/ni2
a?aeiia?aeii (p > 0,05).

sse na?ae/aoue ?acoeueoaoe aeine?aeaeaiiy, i?oei?noue c’?aeiaiiy ?ioeo
a?iieanoe/ieo iaoa??ae?a AOEE oa eea?i «Tissucol» ? i?eaeecii
iaeiaeiaith. Oae, iaaea i?oeiino? neeathaaiiy a?iieanoe/ieo iaoa??ae?a
aeey AOEE a ?yae? o?yu + o?yu; oe??a + oe??a; e?noea + e?noea; oanoe?y +
oanoe?y; i’yc + i’yc noaiiaeoue 5,5; 5,1; 6,0; 6,5; 6,3 I/ni2
a?aeiia?aeii, a aeey eeath «Tissucol» — 6,2; 5,9; 5,8; 6,5; 7,0 I/ni2
a?aeiia?aeii (p > 0,05).

Niaoe?aeuei? aeine?aee aoee i?enay/ai? aenia?eiaioaeueiiio aea/aiith
aieeao AOEE ia ?aia?aoeai? i?ioeane a oeaieiao.

I?iaaaeai? i?e?ia?noieia?/i? aeine?aeaeaiiy uiaei a?aeiiaeaiiy
aa?aaaiii? ia?aoeiee i?e oeiiaiiieanoeoe? ?c canoinoaaiiyi
oanoe?aeueiiai eeaioy a aenia?eiaio? ia e?ieyo ii?iaee “Oeioeea”,
o?eniaaiiai ca aeiiiiiaith AOEE, iieacaee, ui o?ainieaioao iaae?eii
oo?eioaaany ia i?noe? o an?o aeiaaeeao ? ia ci?uoaaany o ii??aiyii? ?c
eiio?ieai, aea iaee i?noea 3 aeiaaeee ci?uaiiy eeaioy. A?eueo ?aii?e
ii/aoie ?aaaia?aoe?? ai?aea?i?no oa ai?oae?th neeciai? iaieiiee ie
a?aei?oeee ia 3-7 aeiao i?ney iia?aoe?? o aeine?aei?e a?oi? (o
eiio?ieuei?e a?oi? – ia 7-15 aeiao), ui o iaeaooiueiio i?ecaiaeeei aei
iiyae a?eueo i?aeieo ?oaoe?a o ii??aiyii? c eiio?ieueiith a?oiith.
Canoiniaoth/e AOEE, ie a?aei?oeee a?eueo iia?eueio aeano?oeoe?th
aieieienoiai inoiao eeaioy, ?aiiaeaethaaiiy a?aeaoaaeiny iia?euei?oa, ui
i?ecaiaeeei aei oi?ioaaiiy a?eueo oiieeo io/e?a eieaaaiiaeo aieieii, ui
iaee, ye i?aaeei, aii?yaeeiaai?oo i???ioaoe?th, i?ae o eiio?ie?.
Ci?uaiiy eeaio?a i?e iia?aoe?? aac eeath aeeeeeaei ??cea iineeaiiy
i?ie?oa?aoeaieo i?ioean?a o niieo/i?e oeaiei? ? ooai?aiiy oianoeo a?oaeo
?oaoe?a.

II. Ee?i?/ia canoinoaaiiy AOEE

Ee?i?/i? ?acoeueoaoe ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?e c i?eaiaeo
OANI aea/ai? o 164 oai?eo. ?iciiae?e oai?eo ca oeiii iia?aoeaiiai
ao?o/aiiy oa canoiniaaiiio eeath i?eaaaeaiee a oaae.

Oaaeeoey

?iciiae?e oai?eo ca oeiii iiapaoeaiiai ao?o/aiiy oa canoiniaaiiio eeath

OeiiaiiieanoeeaA?oie oai?eoE?euee?noue

oai?eoEiio?ieue (1-a a?oia)AOEE

(2-a a?oia)“O?nnoeie” (3-a a?oia)I??eiaiieanoeea e 1-e oei
oeiiaiiieanoeee20171653II-e aoai oeiiaiiieanoeee22231863IV-e oei
oeiiaiiieanoeee18151548Anueiai:605549164Iiia?aaei? ianoaaeaiiy oai?iai,
ui iinooiaa ia e?eoaaiiy aei noaoe?iia?o, aeeth/aei ioe?ieo nea?a oa
aiaiiaco, ioineii?th, aoae?iiao??th, ioii?e?ineii?th, aeine?aeaeaiiy
ooieoe?? neooiai? o?oae, na?ieia?/ia, aaeoa??ieia?/ia aeine?aeaeaiiy, a
oaeiae aeine?aeaeaiiy noaio iina, iaaeieiiiniaeo ii?iaeiei, iiniai? oa
?ioiai? /anoei aeioee ? ai?oai?.

I?e iaeyae? aeioee oa iina o 36 iaoe??io?a aeyaeai? noiooi?
caoai?thaaiiy EI?-i?aai?a: o 10 – o?ii?/iee oiicee?o, o 12 – aee?eaeaiiy
iiniai? ia?aoeiee, o 6 – o?ii?/iee neio?o, o 2 – a?ia?o?io?/iee ?ei?o.
On?i oai?ei c aeyaeaiith iaoieia??th i?iaaaeaia a?aeiia?aeia
eiina?aaoeaia /e o??o?a?/ia e?eoaaiiy.

Iaoiaeeea oa ?acoeueoaoe oeiiaiiieanoeee ?c canoinoaaiiyi AOEE.
Iia?aoeaiee i?aeo?ae aei no?oeoo? na?aaeiueiai aooa cae?enithaaany
aiaeiiaaoaeueii. On? o??o?a?/i? ao?o/aiiy aeeiioaaeeny i?ae iia?aoe?eiei
i?e?ineiiii ?c canoinoaaiiyi i?noeaai? ?io?eueo?aoe?eii? aianoac?? oe??e
ciai?oiueiai neooiaiai i?ioiaeo 2 % ?ic/eiii iiaiea?io c aeiaeaoeii aei
iueiai 0,1 % ?ic/eio aae?aiae?io o ni?aa?aeiioaii? 10:1. ?c ciai?oiueiai
oa?o oanoe?? aeneiaiai i’yco oi?ioaaany iaiao?aeii? oi?ie oa ?ici???a
o?ainieaioao aeey a?aeiiaeaiiy aeaoaeoa aa?aaaiii? ia?aoeiee. ?aiueia?
iiaa?oi? aenoooaaee a?ae e?ia?, i?ney /iai o?ainieaioao oeeaaeaee ia
i?aeaioiaeaia i?noea. Iine?aeiaii i?aei?iath/e e?a? o?ainieaioaoo,
iaiineee a i?noey eiai c’?aeiaiiy c i?aeeaaeeie oeaieiaie ??aio
e?euee?noue 1-ai oa 2-ai eiiiiiaio?a AOEE, ye? ciaoiaeeeenue o aeaio
iaeii?aciaeo oi?eoeao, i?ney /iai eeaiioue oeeaaeaee ia iiia?aaei?
i?noea. Oae o?enoaaee o?ainieaioao ii onueiio ia?eiao?o. I?e o?enaoe??
o?ainieaioao?a o?a?eiiaei eea?i “Tissucol” aeei?enoiaoaaee o??iiao
nenoaio “Aeoieiaeaeaeo”, yea aeicaieyea iaeii/anii iiaeaaaoe ??aio
e?euee?noue 1-ai oa 2-ai eiiiiiaio?a eeath.

I?e aeeiiaii? II aoaio oeiiaiiieanoeee ie aeei?enoiaoaaee eeaeia?
eiiiiceoe?? aeey o?enaoe?? eiethiaee aei aie?aee /e aei ieanoeiee
no?ai?ioey, a oaeiae aeey o?enaoe?? eiethiaee aei aioo??oiuei? iiaa?oi?
iaioeiiaiaeueii? iaia?aie.

I?e aeeiiaii? IV oeio oeiiaiiieanoeee eeaeiaeie eiiiiceoe?yie
i?iaiaeeeany o?enaoe?y oanoe?? aeneiaiai i’yco aei e?noeiaiai
aa?aaaiiiai e?eueoey ? oaeiae aei a?aeiia?aeii? ae?eyiee iaae?aeueii?
no?iee aa?aaaiii? ii?iaeieie.

O an?o oai?eo, o yeeo i?e oeiiaiiieanoeoe? aeei?enoiaoaaee AOEE ? eeae
“Tissucol”, oe??o neooiaiai i?ioiaeo o?enoaaee aei i?aeeaaei? e?noee
aeuacaaaeaieie eiiiiceoe?yie.

I?e aeeiiaii? i??eiaiieanoeee oa I oeio oeiiaiiieanoeee iacia/ia
iioiauaiiy neeciai? iaieiiee ia iaae?aeuei?e no?ioe? aa?aaaiii?
ii?iaeieie aoei o 23 iaoe??io?a 2 oa 3-? a?oie, cia/ii iioiauaia — o 10.
O eiio?ieuei?e a?oi? o 16 oai?eo neeciaa iaieiiea aoea iacia/ii
iioiauaia, o 4 a?aei?/aeiny ?? cia/ia iioiauaiiy oa iaaaeeea e?euee?noue
neeciai-ai?eieo aeae?eaiue.

A?aeaeaeai? ?acoeueoaoe ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?e ia aon?
aea/aeeny iaie a no?iee a?ae 6 i?n. aei 1,5 ?iee.

A 1-e (eiio?ieuei?e) a?oi? 6 /ieia?e aoee aeienai? c iaiiaiith
ai?aea?i?caoe??th iaioeiiaiaeueii? iaia?aie, o 5 iaoe??io?a ooai?eeeny
no?ee? ia?oi?aoe?? iaioeiiaiaeueiiai eeaioy, o ?ioeo 15 iaioeiiaiaeueia
iaia?aia aoea n??iai eieuei?o, ?ooeeaa. O iaoe??io?a 2-? oa 3-? a?oi ie
ia niinoa??aaee iiae?aieo oneeaaeiaiue. A 1 aeiaaeeo o iaoe??ioa 2-?
a?oie oa 2 iaoe??io?a 3-? a?oie iaioeiiaiaeueia iaia?aia aoea iaiaaeaii
?ooeeaa.

Na?aaei? aaee/eie iia?o?yiii?iaaaeaieo oii?a o iaoe??io?a 2-? oa 3-?
a?oi aei iia?aoe?? noaiiaeee: 34,4 0,9 aeA oa 33,2 0,8 aeA
a?aeiia?aeii, o eiio?ieuei?e a?oi? niinoa?aaeaiue – 34,1 0,9 aeA. O
a?aeaeaeaiiio i?neyiia?aoe?eiiio ia??iae? aiie aeinoia??ii (p < 0,05) ciaioeeeny aei 15,3 0,9 aeA oa 13,3 0,9 aeA o iaoe??io?a 2-? oa 3-? a?oi a?aeiia?aeii; o eiio?ieuei?e a?oi? oeae iieaciee noaiiaea 26,9 0,9 aeA. ?ioo oaiaeaioe?th iaee na?aaeiueinoaoenoe/i? iieacieee e?noeiaii?iaaaeaieo oii?a: aei iia?aoe?? aiie noaiiaeee o oai?eo 2-? oa 3-? a?oi 9,8 0,2 aeA oa 10,2 0,2 aeA, o a?aeae?eaiiio i?neyiia?aoe?eiiio ia??iae? – 9,6 0,3 aeA oa 9,4 0,3 aeA a?aeiia?aeii; o eiio?ieuei?e a?oi? niinoa?aaeaiue oe? iieacieee aoee oaeeie: aei iia?aoe?? – 9,5 0,2 aeA, i?ney iia?aoe?? – 9,3 0,2 aeA (p > 0,05).

Ie niinoa??aaee aeinoia??ia ciaioaiiy ii?ia?a e?noeiai-iia?o?yiiai
?ioa?aaeo ia aeine?aeaeoaaieo /anoioao o oai?eo 2-? oa 3-? a?oi: aei
iia?aoe?? oe? iieacieee aei??aithaaee 24,21,5 aeA oa 22,11,2 aeA, i?ney
iia?aoe?? – 8,61,2 aeA oa 8,01,5 aeA a?aeiia?aeii (p < 0,05); o eiio?ieuei?e a?oi? niinoa?aaeaiue: aei iia?aoe?? – 22,51,4 aeA, i?ney iia?aoe?? – 16,51,4 aeA (p < 0,05). A?eueo ae?aaeaia, aeinoia??ia ciaioaiiy ii?ia?a e?noeiai-iia?o?yiiai ?ioa?aaeo o a?aeaeaeaiiio i?neyiia?aoe?eiiio ia??iae? ia aeine?aeaeoaaieo /anoioao o oai?eo 2–? oa 3-? a?oie (8,6 1,2 aeA oa 8,0 1,5 aeA a?aeiia?aeii) o ii??aiyii? c eiio?ieueiith a?oiith (16,5 1,4 aeA) (p < 0,05), iiaea na?ae/eoe i?i e?aua a?aeiiaeaiiy caoeii?ia?aeii? nenoaie, ia ui aeacothoue ? ii?oieia?/i? ?acoeueoaoe. I?e iaeyae? oai?eo, ui iinooieee ia II aoai oeiiaiiieanoeee, o an?o aoei aeyaeaii oe?eo ? ?ooiio iaioeiiaiaeueio iaia?aio. I?ney a?aeoa?oaaiiy iaaoioeiiaiaeueiiai eeaioy o 17 iaoe??io?a 2-? ? 3-? a?oi aoei ciaeaeaii iiai?noth caa?aaeaia ? ?ooiia no?ai?ioea, a o 24 aoea caa?aaeaia eeoa eiai ieanoeiea. O 10 in?a eiio?ieueii? a?oie aoei caa?aaeaia no?ai?ioea, o 12 – o?eueee eiai iniiaa. O oai?eo 2-? oa 3-? a?oi eeae canoiniaoaaee aeey a?eueo iaae?eii? o?enaoe?? aanoeaoey?iiai e?ioey i?ioaco aei aie?aee no?ai?ioey aai aei eiai iniiae. O?aaeeoe?eia oaiiiiaaea neooiaiai i?ioiaeo ia aeeiioaaeany, oiio ui oe??a ciai?oiueiai neooiaiai i?ioiaeo o?enoaaeany aei i?aeeaaei? e?noee ca aeiiiiiaith eeath. Ui noino?oueny ooieoe?iiaeueieo ?acoeueoao?a II aoaio oeiiaiiieanoeee, eiee i?ae iiia?aaeiuei noi?iiaaiith iaioeiiaiaeueiith iaia?aiith ? aie?aeith (/e iniiaith) no?ai?ioey anoaaeyeany eieoiaea, oi canoinoaaiiy eeaeiaeo eiiiiceoe?e aeyaeeinue a?eueo aoaeoeaiei. Oea e c?icoi?ei, ai iaa?oue iacia/ia ci?uaiiy oeiiaiaeueiiai /e no?ai?ioeaaiai e?ioey eieoiaee i?ecaiaeeoue aei iiaii? /e /anoeiai? ao?aoe neooo, io?eiaiiai i?ae /an iia?aoe??. I?i oea na?ae/aoue io?eiai? iaie a?aeaeaeai? ?acoeueoaoe: na?aaeiy aaee/eia EI? i?e canoinoaaii? AOEE ? eeath "Tissucol" noaiiaeea 16,8 1,3 aeA; 16,2 1,3 aeA a?aeiia?aeii, oiae? ye o eiio?ieuei?e a?oi? oeae iieaciee noaiiaea 23,3 1,5 aeA (p < 0,05). Aaaeeeaei ? ieoaiiy i?i iiaeeeaee aieea eeaeiai? eiiiiceoe?? ia ooieoe?th caoeini?eeiath/iai aia?aoo caaeoee o oeo aeiaaeeao, eiee eeae iaiineee ia ieanoeieo no?ai?ioey, o?enoth/e anoaiiaeaiee ia ia? e?iaoeue eieoiaee. sse na?ae/aoue io?eiai? iaie aeai?, na?aaeiy aaee/eia ii?ia?a e?noeiaii?iaaaeaieo caoe?a i?ney canoinoaaiiy AOEE oa eeath "Tissucol" (aei iia?aoe?? – 14,8 0,6 aeA oa 15,1 0,6 aeA; i?ney iia?aoe?? – 13,9 0,7 aeA oa 14,8 0,7 aeA a?aeiia?aeii; o a?aeaeaeaiiio ia??iae? – 13,1 0,5 aeA ? 13,2 0,6 aeA a?aeiia?aeii) nooo?ai ia a?ae??ciyeeny (p > 0,05). Oea, a oaeiae aeai? i?i aeine?aeaeaiiy
ooieoe?? caaeoee iaii?iaiaeie oanoaie, aeaco? ia a?aenooi?noue
oiene/iiai aieeao eiiiiiaio?a eiiiiceoe?? ia aioo??oi? aooi. O an?o
oai?eo aei oa i?ney iia?aoe?? cia/aiiy oanoo Ethoa? aoei a iaaeao 1,0 –
1,5 aeA. SiSi-oanoa – a?ae 0 aei 30 % iiceoeaieo a?aeiia?aeae.

Ee?i?/ia ioe?iea oai?eo, yeei aoa aeeiiaiee IV oei oeiiaiiieanoeee,
i?iaiaeeeany i?e aini?oae?caoe??, o iaeaeeae/iio oa a?aeaeaeaiiio
i?neyiia?aoe?eiiio ia??iae?.

O 21 oai?iai 2-? oa 3-? a?oi ie aeyaeee, ui oeiiaiaeueiee ioa?? neooiai?
o?oae aoa a?aee?eoee, aeae?eaiue ia aoei, ooieoe?y neooiai? o?oae aoea I
oa II nooiaith. O 9 iaoe??io?a 2-? ? 3-? a?oi ioa?? neooiai? o?oae aoa
cae?eoee ?oaoeai, i?ae yeei ciaoiaeeeany neeciaa iaieiiea. O
eiio?ieuei?e a?oi? o 12 iaoe??io?a ioa?? neooiai? o?oae aoa a?aee?eoee,
a o 6 – cae?eoee oiieei ?ooeeaei ?oaoeai, i?ae yeei aoea neeciaa
iaieiiea.

Na?aaei? aaee/eie iia?o?yiii?iaaaeaieo oii?a o iaoe??io?a 2-? oa 3-?
a?oi aei iia?aoe?? noaiiaeee: 62,4 0,9 aeA oa 61,7 0,9 aeA
a?aeiia?aeii, o eiio?ieuei?e a?oi? niinoa?aaeaiue – 59,3 0,8 aeA. O
a?aeaeaeaiiio i?neyiia?aoe?eiiio ia??iae? aiie aeinoia??ii (p < 0,05) ciaioeeeny aei 43,7 0,9 aeA oa 42,5 0,9 aeA o iaoe??io?a 2-? oa 3-? a?oi a?aeiia?aeii; o eiio?ieuei?e a?oi? oeae iieaciee noaiiaea 51,8 0,8 aeA. Na?aaeiueinoaoenoe/i? iieacieee e?noeiaii?iaaaeaieo oii?a aei iia?aoe?? noaiiaeee o oai?eo 2-? oa 3-? a?oi 10,9 1,3 aeA oa 11,1 1,1 aeA, o a?aeae?eaiiio i?neyiia?aoe?eiiio ia??iae? – 11,1 1,3 aeA oa 11,5 1,1 aeA a?aeiia?aeii; o eiio?ieuei?e a?oi? niinoa?aaeaiue oe? iieacieee aoee oaeeie: aei iia?aoe?? – 12,0 1,4 aeA, o a?aeaeaeaiiio i?neyiia?aoe?eiiio ia??iae? – 13,0 1,1 aeA. sse na?ae/aoue ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue, na?aaeiy aaee/eia EI? aei iia?aoe?? noaiiaeea: o oai?eo 2-? a?oie – 51,5 0,9 aeA, 3-? a?oie – 50,6 1,6 aeA, a eiio?ieuei?e a?oi? – 47,3 1,1 aeA; o a?aeaeaeaiiio ia??iae? i?ney IV oeio oeiiaiiieanoeee ?c canoinoaaiiyi AOEE ? "Tissucol" oeae iieaciee noaiiaea 32,6 0,8 aeA oa 31,0 1,3 aeA o 2-e oa 3-e a?oiao a?aeiia?aeii, oiae? ye o eiio?ieuei?e a?oi? – 38,8 0,9 aeA. Iniiaiith i?e/eiith iaaaoeaieo ooieoe?iiaeueieo ?acoeueoao?a i?e IV oei? oeiiaiiieanoeee ? noai?aiiy iaiiaiioe?iii? iia?o?yii? ii?iaeieie, eiee aiane?aeie c?iuaiiy iaioeiiaiaeueiiai eeaioy c i?iiiioi??aeueiith no?ieith ia aaea?oueny caa?aaoe iia?o?yiee i?ino?? iaae i?oith a?eia caaeoee. Iaei??th c i?e/ei, ui i?ecaiaeyoue aei oeueiai, ? ci?uaiiy oeiiaiiieanoe/iiai eeaioy i?ae /an iia?aoe??, eiee a?i cnoaa?oueny iaae?aeueii ? oi?ea?oueny i?iiiioi??aeueii? no?iee. Canoinoaaiiy eeaeiai? eiiiiceoe?? aeey o?enaoe?? e?a?a o?ainieaioaoo o a?aeiia?aeiiio iieiaeaii? aeicaiey? o cia/i?e i??? oieeiooe oeeo iaaaaeaieo oneeaaeiaiue. AENIIAEE 1. ?ic?iaeaii aooio?a?eiiao eeaeiao eiiiiceoe?th, ui a?ae??ciy?oueny a?ae ?nioth/eo iayai?noth o i?e aioea?ioee?a ? e?cioeeia, ye? o oa?aiaaoe/ieo eiioeaio?aoe?yo caa??aathoue naith aioei?e?iaio aeoeai?noue ia i?ioyc? 7 – 10 aei?a. 2. Cai?iiiiiaaiee iaoiae noa?ee?caoe?? eiiiiceoe?? -ii?ii?iaiiyi o aeic? 75 A? ia aieeaa? ia i?oei?noue eeaeiaiai c'?aeiaiiy oeaiei, a oaeiae ia a?io?i?/io oa?aeoa?enoeeo eiiiiceoe??. 3. A aenia?eiaio? ia e?ieyo iieacaii, ui, caaaeyee canoinoaaiith AOEE aeey o?enaoe?? oeiiaiiieanoe/iiai o?ainieaioaoo c oanoe?? ne?iiaaiai i’yco, ?aaaia?aoeaii-?aia?aoeai? i?ioeane o i?noe? eeaeiaiai niieo/aiiy i?ioiaeyoue o a?eueo ?aii? oa?i?ie, i?ae o eiio?ie?, a ia?aa?a i?ioean?a ?aaaia?aoe?? ia i?ecaiaeeoue aei ooai?aiiy a?oai? ?oaoeaai? oeaieie. 4. AOEE ia aeeeeea? i?eai?/aiiy ooieoe?? caaeoee i?e eiioaeo? c iniiaith no?ai?ioey. 5. Canoinoaaiiy AOEE aeicaiey? iie?aueoe ii?oieia?/i? oa ooieoe?iiaeuei? ?acoeueoaoe, ciaioeoe ?ecee i?neyiia?aoe?eieo oneeaaeiaiue ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?e ia aon? o oai?eo ia OANI. 6. Aeine?aeaeaiiy a?io?i?/ieo oa aaeaaceaieo aeanoeainoae cai?iiiiiaaii? iaie AOEE, a oaeiae ?acoeueoaoe ee?i?/iiai canoinoaaiiy i?e oeiiaiiieanoeoe? na?ae/aoue i?i oa, ui aiia ia iinooia?oueny iioe?aiiio ca ei?aeiiii o?a?eiiaiio eeath ”Tissucol” o??ie “Immuno”, a ?? aeei?enoaiiy ? aeioe?eueiei oaeiae aeiiii?/ii. I?aeoe/i? ?aeiiaiaeaoe??. 1. C iaoith i?aeaeuaiiy aoaeoeaiino? o??o?a?/iiai e?eoaaiiy oai?eo ia OANI ?aeiiaiaeo?oueny aeei?enoiaoaaoe AOEE aeey c’?aeiaiiy a?iieanoe/ieo iaoa??ae?a. 2. Noa?ee?caoe?th eiiiiceoe?? ?aeiiaiaeo?oueny i?iaiaeeoe -ii?ii?iaiiyi a aeic? 75 A?. 3. I?e aeei?enoaii? AOEE ?aeiiaiaeo?oueny iaiineoe ii /a?c? I oa II eiiiiiaioe eiiiiceoe?? o ??ai?e e?eueeino? a i?noey c`?aeiaiiy a?iieanoe/ieo iaoa??ae?a. 4. Canoinoaaiiy AOEE aeey o?enaoe?? oe??e ciai?oiueiai neooiaiai i?ioiaeo aei i?aeeaaei? e?noee ia caaa?oaeueiiio aoai? iia?aoe?? aeicaiey? a?aeiiaeoeny a?ae eeane/ii? oaiiiiaaee. NIENIE I?AOeUe OA AEIAOIAe?A, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. I?eiaiaiea oea?eiiaiai eeay “TISSUCOL” i?e oeiiaiiieanoeea // AEo?iae ooiuo, iiniauo e ai?eiauo aieaciae. – 1991. – ?4 – N.55-56. (Ni?aaao.: Nooei TH.A., Ai?enaiei I.I.). 2. Iaoaie/aneay i?i/iinoue niaaeeiaiey aeiieanoe/aneeo iaoa?eaeia oea?eiiaui eeaai // AEo?iae ooiuo, iiniauo e ai?eiauo aieaciae. – 1992. – ?1 – N.24-26. (Ni?aaao.: Eecei A.E.) 3. I?eiaiaiea ?acee/iuo oeiia iaaeeoeeineiai eeay a ioi?eiiea?eiaieiaee // AEo?iae ooiuo, iiniauo e ai?eiauo aieaciae. – 1993. – ?5-6. – N.67-72. 4. I?eiaiaiea aooioea?eiiaie eeaaaie eiiiiceoeee i?e ?aeiino?oeoeaii-ainnoaiiaeoaeueiuo iia?aoeeyo ia ooa // No/ani? i?iaeaie ioi?eiiea?eiaieia??. Ca. iaoe. i?aoeue, i?enay/aieo 95-??//th c aeiy ia?iaeaeaiiy i?io. I.N.Eieii?e/aiea. – Ee?a: 1993. – N.143-144. 5. Ninoaa aeey niaaeeiaiey aeiieanoe/aneeo iaoa?eaeia a ioioe?o?aee (iaoaio ?innee ? 2030183 io 10.03.95) (Ni?aaao. Nooei TH.A., Aa?aiaaiei E.I., Eecei A.E., *a?iaoa E.E.). 6. Ii?oieiaey ainnoaiiaeoaeueiuo i?ioeannia i?e oeiiaiiieanoeea oanoeeaeueiui eineooii a yenia?eiaioa n eniieueciaaieai aooioea?eiiaie eeaaaie eiiiiceoeee. A ei.: Iaoa?eaeu XV Ana?inneeneiai nuacaea ioi?eiiea?eiaieiaia, 25-29 naioya?y 1995 a. – NIa. – Oii 1. N.448-453 . 7. I?eiaiaiea aooioea?eiiaie eeaaaie eiiiiceoeee i?e oeiiaiiieanoeea. A ei.: Oace VIII c’?caeo ioi?eiiea?eiaieia?a Oe?a?ie, 5-10 /a?aiy 1995 ?. – Ee?a. – N. 330. 8. Can?a oeiiaiiieanoeee (Iaoaio Oe?a?ie ? 94128300 a?ae 20.02.97) (Ni?aaao.: Nooei TH.I., Ai?enaiei I.I., Iie?uoe A.N.). 9. Aooioea?eiiaay eeaaaay eiiiiceoeey e aa i?eiaiaiea i?e ?aeiino?oeoeaiuo iia?aoeeyo ia ooa // Iaoa?. iaoe.-i?aeo. eiio., i?enay/aii? 100-??//th c aeiy ia?iaeaeaiiy i?io. I.N.Eieii?e/aiea, 30 aa?aciy – 2 ea?oiy 1998 ?. – Ee?a, 1998. – N.690-697. 10. Autofibrin glue composition in otosurgery – Politzer society meeting. – Punta-Ala, Italy. – August 29 - september 2, 1995. – S.40-41. (Ni?aaao.: Sushko Y.A., Borisenko O.N.). 11. I?eeiyoi aei ae?oeo: Schatkovskaya N.Y., Soushko Y.A., Veremeenko K.N., Kizim A.I., Borissenko O.N. Autofibrin glue composition and its utilisation during reconstructive operations on ear // Revue de Laryngologie. Oaoe?anueea I.TH. – Aenia?eiaioaeueii-ee?i?/ia iaa?oiooaaiiy canoinoaaiiy aooio?a?eiiai? eeaeiai? eiiiiceoe?? i?e ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?yo ia aon?. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.19 – ioi?eiiea?eiaieia?y. – Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ioiea?eiaieia?? ?i. i?io. I.N.Eieii?e/aiea IIC Oe?a?ie, Ee?a, 1998. Aeena?oaoe?y i?enay/aia i?iaeai? iaa?oiooaaiiy canoinoaaiiy iie?ia??a o?a?eio i?e ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?yo ia aon? o oai?eo ia o?ii?/iee ai?eiee na?aaei?e ioeo. Aia?oa ?ic?iaeaiee neeaae, iaoiaeeea io?eiaiiy oa canoinoaaiiy a ee?i?oe? i?e ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?yo ia aon? eeaeiai? eiiiiceoe?? c e?ia? iaoe??ioa. Aea/ai? ?? a?io?i?/i?, i?e?ia?ieia?/i? oa aaeaaceai? aeanoeaino?. Aaaaeai? aei eiiiiceoe?? aioea?ioee oa e?cioeei caa??aathoue naith aeoeai?noue, ia ii?oooth/e aeanoeainoae iniiae eiiiiceoe?? (o?a?eiiaaio ? o?iia?io). Aeiaaaeaii, ui noa?ee?caoe?y eiiiiceoe?? aaia-ii?ii?iaiiyi ia ii?ooo? ?? iniiaieo aeanoeainoae. A aenia?eiaio? ia i?aeaeine?aeieo oaa?eiao aeiaaaeaii, ui ii?oieia?/i? i?ioeane a?aeiiaeaiiy aa?aaaiii? ia?aoeiee ?c canoinoaaiiyi AOEE i?ioiaeyoue o a?eueo ?aii? oa?i?ie, i?ae o eiio?ie?. Ee?i?/i? aeine?aeaeaiiy, i?iaaaeaii? i?e e?eoaaii? 164 oai?eo ia o?ii?/iee ai?eiee na?aaei?e ioeo, aeicaieeee anoaiiaeoe, ui ?acoeueoaoe iia?aoe?e ?c canoinoaaiiyi AOEE oa o?a?eiiaiai eeath “Tissucol” e?au?, i?ae o eiio?ieuei?e a?oi? niinoa?aaeaiue. Canoinoaaiiy o?a?eiiaeo iie?ia??a aeicaieeei ciaioeoe ?ecee i?neyiia?aoe?eieo oneeaaeiaiue, caaacia/eoe a?eueo no?ee? ii?oieia?/i? oa ooieoe?iiaeuei? ?acoeueoaoe o a?aeaeaeaiiio ia??iae? i?ney ?aeiino?oeoeaii-a?aeiiaieo iia?aoe?e ia aon?. Eeth/ia? neiaa: o?ii?/iee ai?eiee na?aaei?e ioeo, oeiiaiiieanoeea, a?ieia?/i? iie?ia?e o?a?eio. Oaoeianeay I.TH. Yenia?eiaioaeueii-eeeie/aneia iainiiaaiea i?eiaiaiey aooioea?eiiaie eeaaaie eiiiiceoeee i?e ?aeiino?oeoeaii-ainnoaiiaeoaeueiuo iia?aoeey ia ooa. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.19 – ioi?eiiea?eiaieiaey. – Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo ioiea?eiaieiaee ei. i?io. A.E.Eieiiee/aiei, IC Oe?aeiu, Eeaa, 1998. Aeenna?oaoeey iinayuaia i?iaeaia iainiiaaiey i?eiaiaiey iieeia?ia oea?eia i?e ?aeiino?oeoeaii-ainnoaiiaeoaeueiuo iia?aoeeyo ia ooa o aieueiuo o?iie/aneei aiieiui n?aaeiei ioeoii. Aia?aua ?ac?aaioai ninoaa, iaoiaeeea iieo/aiey e i?eiaiaiea a eeeieea i?e ?aeiino?oeoeaii-ainnoiiaeoaeueiuo iia?aoeeyo ia ooa eeaaaie eiiiiceoeee ec e?iae iaoeeaioa. Eco/aiu aa aeioeie/aneea, iee?iaeieiae/aneea e aaeaaceaiua naienoaa. Aaaaeaiiua a eiiiiceoeeth aioeaeioee e eecioeei nio?aiyao naith aeoeaiinoue, ia ia?ooay naienoa iniiau eiiiiceoeee (oea?eiiaaia e o?iiaeia). Aeieacaii, /oi noa?eeecaoeey eiiiiceoeee aaiia-eo/aie ia ia?ooaao aa iniiaiuo naienoa. A yenia?eiaioa ia iiaeiiuoiuo aeeaioiuo aeieacaii, /oi ii?oieiae/aneea i?ioeannu ainnoaiiaeaiey aa?aaaiiie ia?aiiiee n i?eiaiaieai AOEE i?ioiaeyo a aieaa ?aiiea n?iee, /ai a eiio?iea. Eeeie/aneea enneaaeiaaiey, i?iaaaeaiiua i?e ea/aiee 164 aieueiuo o?iie/aneei aiieiui n?aaeiei ioeoii iicaieeee onoaiiaeoue, /oi ?acoeueoaou iia?aoeee n i?eiaiaieai AOEE e oea?eiiaiai eeay “Tissucol” eo/oa, /ai a eiio?ieueiie a?oiia iaaethaeaiee. I?eiaiaiea oea?eiiauo iieeia?ia iicaieeei oiaiueoeoue ?ene iineaiia?aoeeiiiuo ineiaeiaiee, iaania/eoue aieaa noieeea ii?oieiae/aneea e ooieoeeiiaeueiua ?acoeueoaou a ioaeaeaiiii ia?eiaea iinea ?aeiino?oeoeaii-ainnoaiiaeoaeueiuo iia?aoeee ia ooa. Eeth/aaua neiaa: o?iie/aneee aiieiue n?aaeiee ioeo, oeiiaiiieanoeea, aeieiae/aneea iieeia?u oea?eia. Shatkovskaya N.Yu. Experimental and clinic substantiation of autofibrin glue composition application during reparative-and-plastic operations on the ear. – Manuscript. Dissertation for obtaining scientific degree of Candidate of Science (Medicine) in speciality 14.01.19. – Otolaryngology, - Kiev Research Institute of Otolaryngology named after Prof. Kolomiychenko, Ministry of Public Health of Ukraine, Kiev, 1998. The dissertation concerns the problem of fibrin polymers application during reparative-and-plastic operations on the ear of the patients with chronic suppurative inflammation of middle ear. For the first time the structure, methods of obtaining from patient’s blood and utilization of glue composition during reparative-and-plastic operation on the ear were developed. Its biochemical, microbiological and adhesive characteristics were studied. Antibiotics and lysozime injected into the composition preserve their activity without breaking the qualities of the composition basis (fibrinogen and thrombin). It was proved that sterilization of the composition by gamma-rays doesn’t break its basic qualities. It was estimated on experimental animals that morphological recovery processes of tympanic membrane due to AFGC utilization occur faster than during control conditions. Clinic research of 164 patients with chronic suppurative inflammation of middle ear established that the results of operations with AFGC application and fibrin glue “Tissucol” are much more better than in the control group of patients. The utilization of fibrin-polymers made it possible to decrease the risk of post-operation complication and ensure stable morphological and functional results after the operations on the ear. Key words: chronic purulent otitis media, tympanoplastic, biological polymers of fibrin. I?aeienaii aei ae?oeo 26.10.98 Oi?iao 60o90/16. Oe?aae 100 i?. Cai. ? 481 Oei. NAO Ee?a, aoe.Oano?anueea, 8

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