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Експериментальне вивчення нових лікарських форм Лоратадину для лікування алергічних ринітів та дерматитів: Автореф. дис… канд. біол. наук / Р.Ф. Єрь

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AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OA?IAEIEIA?? OA OIENEEIEIA??

??ueiiaiei ?eiia Ooao?aia

OAeE:615.218.615.651.

Aenia?eiaioaeueia aea/aiiy iiaeo e?ea?nueeeo oi?i

Ei?aoaaeeio aeey e?eoaaiiy aea?a?eieo ?ei?o?a oa

aea?iaoeo?a

14.03. 05 – oa?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a eaai?aoi??? ?ioiioa?iaeieia?? oa aea?aieia??
Aea?aeaaiiai iaoeiaiai oeaio?o e?ea?nueeeo cania?a

Iaoeiaee ea??aiee: eaiaeeaeao a?ieia?/ieo iaoe, Aaeaeaiaea Ieaenaiae?
A?eoi?iae/,

Aea?aeaaiee iaoeiaee oeaio? e?ea?nueeeo cania?a, noa?oee iaoeiaee
ni?a?ia?oiee, caa?aeoaa/ eaai?aoi??? ?ioiioa?iaeieia?? oa aea?aieia??

Io?oe?ei? iiiiaioe: Aeieoi? a?ieia?/ieo iaoe, Ni?aae Ieeiea sseiaeaae/,
?inoeooo i?e?ia?ieia?? oa a??onieia?? IAI Oe?a?ie, caa?aeoaa/ a?aeae?eo
?ioa?oa?iia oa ?ioiiiiaeoeyoi??a

eaiaeeaeao iaaee/ieo iaoe, A?eaaeue?a Ay/aneaa Aai?a?eiae/,

?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie, noa?oee iaoeiaee
ni?a?ia?oiee a?aeae?eo iaoio?c?ieia??

I?ia?aeia onoaiiaa: Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao

IIC Oe?a?ie, eaoaae?a
oa?iaeieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny “14” aeiaoiy 1999 ?ieo i 13 aiaeei?

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.550.01 i?e ?inoeooo?
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, Ee?a, aoe. A.Iioue?,
14).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie ( 252057, Ee?a, aoe.A.Iioue?,
14).

Aaoi?aoa?ao ?ic?neaiee “12” aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Ae26.550.01.,

eaiaeeaeao a?ieia?/ieo iaoe
?.A.Aeaiiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aea?a?/i? caoai?thaaiiy iaeaaeaoue aei iaeieo c
iaea?eueo iioe?aieo oai?ia ? ioiieththoue aei 10-20% ianaeaiiy.
Caaaeath/e ia aaaeeeao ?ieue a?noai?io o ?icaeoeo aea?a??, a e?eoaaii?
aea?a?/ieo caoai?thaaiue oe?iei aeei?enoiaothoueny aioea?noai?ii? caniae
(E.N Aouei, 1992; 1997)

Iaaaaeai? aoaeoe eeane/ieo aioea?noai?iieo i?aia?ao?a (aeeiaae?ie,
noi?anoei, oaaaaee oa i.) noeioethaaee oe?eani?yiiaaio ?ic?iaeo iiai?
aaia?aoe?? aeieaoi??a I1-?aoeaioi??a a?noai?io (oa?oaiaaeei, anoai?cie,
ei?aoaaeei, oeaoa?ecei, aaanoei oa ?i.), ui iathoue aenieo
nii??aeiai?noue aei I1-?aoeaioi??a a?noai?io, aea ia iathoue nooo?aiai
aieeao ia ?io? oeie ?aoeaioi??a (TH.A. ?aaeueeei, 1996; ?.I. Oaeoia,
1998).

Ei?aoaaeei ? iaeiei c aoaeoeaieo i?ioeaea?a?eieo e?ea?nueeeo cania?a,
yeee ia? oe?iea canoinoaaiiy. Oeae i?aia?ao a oaia??oi?e /an
aeei?enoiao?oueny o oaaeaoiaai?e e?ea?nuee?e oi?i? oa o aeaeyae? ne?iio
(R.G. Dokhorn, 1987; R.G. Davies, 1996) Iaeiae, c o?aooaaiiyi no/anieo
oaiaeaioe?e aei iioei?caoe?? iaaeeeaiaioicii? oa?ai?? oa aaaaoiieaiiaeo
ia?aaaa iaoe??ieo oa iacaeueieo e?ea?nueeeo oi?i, iaea?eueo
aeioe?eueiith aaaaea?oueny ?ic?iaea a?o/eciyiiai i?aia?aoo ia iniia?
Ei?aoaaeeio o aeaeyae? aaey. Iaiao?aei?noue noai?aiiy e?eoaaeueieo
cania?a ia iniia? Ei?aoaaeeio o aeaeyae? aae?a ia noooaa cia/aiiy aeey
aea?iaoieia?? oa ioi?eiiea?eiaieia??, ui i?iaeeeoiaaii aino?ith
iio?aaith aoaeoeaii? oa?iaeioa?ai?? aea?a?eiiai caiaeaiiy. Oea coiiaeaii
oei, ui a no/ani?e aea?iaoieia?? oa ioi?eiiea?eiaieia?? aeey
ciai?oiueiai canoinoaaiiy aeei?enoiaothoueny ei?oeeinoa?i?aei?
i?aia?aoe, aeiaai/ania i?noeaaa canoinoaaiiy yeeo o oi?i? iac? aea?
oei/aniaee aoaeo ? iiaea i?ecaanoe aei oneeaaeiaiue o aeaeyae? ao?io??
oe??e oa neeciai? iaeiiee (A.A. Anoaoiaa, 1986).

O oaia??oi?e /an aaenooi iiae?ai a?o/eciyi i?aia?aoe, oiae? ye iio?aaa
a ieo aeoaea aeniea.

Ca`ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?th
aoei aeeiiaii o a?aeiia?aeiino? aei ieaio iaoeiai-aeine?aeieo ?ia?o
Aea?aeaaiiai iaoeiaiai oeaio?o e?ea?nueeeo cania?a ca oaiith
“Oa?iaeieia?/ia, oaoiieia?/ia oa aiae?oe/ia aeine?aeaeaiiy ii noai?aiith
iacaeueiiai aaeth c Ei?aoaaeeiii” ( ? aea?aeaaii ?a?no?aoe?? 0196.
U023304) ? “Oa?iaeieia?/ia ? oaoiieia?/ia aeine?aeaeaiiy oaaeaoie c
Ei?aoaaeeiii. Noai?aiiy e?ea?nueeiai i?aia?aoo Ei?aoaaeei” ( ?
aea?aeaaii ?a?no?aoe?? 0196. U001577).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith oe??? ?iaioe aoei oa?iaeieia?/ia
aeine?aeaeaiiy aaea c Ei?aoaaeeiii aeey aea?iaoieia oa ioi?eiiea?eiaieia
(“Ei?aaea?i” oa “Ei?ecai”) aecia/aiiy

iniaeeainoae ?oiuei? oa?iaeie?iaoeee oa oa?iaeiaeeiai?ee ca oiia
o?ainaea?iaeueiiai oa iacaeueiiai oeyo?a aaaaeaiiy ii??aiyii c
o?aaeeoe?eiith e?ea?nueeith oi?iith – oaaeaoeaie “Ei?aoaaeeio”.

Aeoiaey/e c iinoaaeaii? iaoe, aoei aecia/aii oae? caaea/?:

1) aeine?aeeoe oa?iaeie?iaoeeo oa a?iaeinooii?noue Ei?aoaaeeio i?e
aaaaeaii? o?ainaea?iaeueii oa iacaeueii eea?nueeeo oi?i o aeaeyae aae?a
oa ii??aiyiiy o c oaaeaoeaie “Ei?aoaaeei”;

2) aea/eoe oa?iaeieia?/io aeoeai?noue (i?ioeaea?a?eio, i?ioecaiaeueio oa
aioea?noai?iio) iiaeo e?ea?nueeeo oi?i Ei?aoaaeeio ca oiia ??cieo oeyo?a
aaaaeaiiy ii??aiyii c oaaeaoeaie “Ei?aoaaeeio” oa ?ioeie
aioea?noai?iieie i?aia?aoaie;

3) aeine?aeeoe aieea o?ainaea?iaeueiiai oa iacaeueiiai aaea Ei?aoaaeeio
ca oiia ?cieo oeyoa aaaaeaiiy ii?aiyii c oaaeaoeaie ia a?io?i?/io oaco
iaoiaaiaco aea?a?/ieo ?aaeoe?e: ai?no a?iaaiieo ai?i?a (a?noai?io ?
na?ioii?io) oa eaeeio?e?i?a A4, N4 oa A4 o e?ia? oa i?aaiao-i?oaiyo
oaa?ei.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa i?iaaaeaii eiiieaenia
ii??aiyeueia aeine?aeaeaiiy oa?iaeie?iaoeee oa oa?iaeiaeeiai?ee
e?ea?nueeeo oi?i Ei?aoaaeeio (oaaeaoie oa aae?a aeey aea?iaoieia?? oa
ioi?eiiea?eiaieia??) o caeaaeiino? a?ae aeaeo e?ea?nueei? oi?ie oa oeyoo
o aaaaeaiiy.

Iieacaii, ui Ei?aoaaeei i?e iaoe??iiio oa iacaeueiiio oeyoao aaaaeaiiy
ni?e/eith? cia/ii a?eueo ae?aaeaiee, o ii??aiyii? c oaaeaoeaie,
oa?aiaaoe/iee aoaeo.

I?iaaaeaii aiae?c caeaaeiino? oa?iaeieia?/ii? aeoeaiino? e?ea?nueeeo
oi?i Ei?aoaaeeio a?ae a?iaeinooiiino? ae?th/i? ?a/iaeie a oiiaao ??cieo
oeyo?a aaaaeaiiy.

Anoaiiaeaii, ui a oiiaao aenia?eiaioaeueieo aea?a?/ieo ?aaeoe?e
aaaeeeaith eaieith o iaoai?ci? ?aae?caoe?? oa?iaeieia?/ii? ae??
Ei?aoaaeeio ? ii?iae?caoe?y eaeeio?e?iiaiai aaeaino oa ??aiy a?iaaiieo
ai?i?a o e?ia? oa i?aaiao-i?oaiyo oaa?ei.

Aia?oa i?iaaaeaii oa?iaeieia?/ia oa oa?iaeie?iaoe/ia aeine?aeaeaiiy
iiaeo e?ea?nueeeo oi?i – aae?a c Ei?aoaaeeiii oa iieacaii
ia?niaeoeai?noue ?o ee?i?/iiai canoinoaaiiy a aea?iaoieia?? oa
ioi?eiiea?eiaieia??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Ia iniia? ?acoeueoao?a
aeiee?i?/iiai aeine?aeaeaiy iiaeo e?ea?nueeeo oi?i Ei?aoaaeeio,
ee?i?/ii? ai?iaaoe?? oaaeaoie “EII-Ei?aoaaeei”, 0,01 (“Ei?aoaaeei”),
“EII-Ei?aaea?i”, aaey (“Ei?aaea?i”), ? “EII-Ei?ecai”, aaey iacaeueiiai
(“Ei?ecai”), i?aia?aoe io?eiaee aeica?e ia iaaee/ia canoinoaaiiy
(?a?no?aoe?eia iina?ae/aiiy ?

?/97/37/10; ?/98/20/1; ?/98/15/6). Ae?iaieoeoai i?aia?ao?a ia iniia?
Ei?aoaaeeia cae?eniaii AAO “Ee?aiaaei?aia?ao”.

Ai?iaaaeaeaiiy iiaeo eea?nueeeo oi?i aeicaieeoue ?icoe?eoe iiiaieeaoo?o
a?o/eciyieo aioea?noai?iieo i?aia?ao?a iiaiai iieie?iiy aeey
canoinoaaiiy a aea?iaoieia?? oa ioi?eiiea?eiaieia??.

?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue ai?iaaaeaeaii o
iaa/aeueiee i?ioean eaoaae? oa?iaeieia??, o?c?ieia?? oa iaoieia??
Oe?a?inueei? Oa?iaoeaaoe/ii? Aeaaeai?? (i. Oa?e?a), a oaeiae
aeei?enoiaoaathoueny ia i?aeoe/ieo caiyooyo ia eaoaae?? oa?iaeieia??
iaaee/iiai oaeoeueoaoo Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii naiino?eii i?iaaaeai
iaoaioii-?ioi?iaoe?eiee iiooe, aaeoai?ai aenia?eiaioaeuei? iiaeae?
iaoieia??, aeeiiaii oa?iaeieia?/i?, o?c?ieia?/i? oa a?io?i?/i?
aeine?aeaeaiiy, i?iaaaeaii noaoenoe/io ia?iaeo oa aiae?c ?acoeueoao?a
aeine?aeaeaiiy.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeaii
? iaaiai?aii ia: oa?iaeieia?/i?e eii?n?? A/aii? ?aaee Aea?aeaaiiai
iaoeiaiai oeaio?o e?ea?nueeeo cania?a (Oa?e?a, 1998); ia VI ?inneeneii
iaoeeiiaeueiii eiia?anna “*aeiaae e eaea?noai” (Iineaa, 1999); ia
Ana?inneeneie iao/iie eiioa?aioeee “Aeooaeueiua i?iaeaiu
yenia?eiaioaeueiie e eeeie/aneie oa?iaeieiaee” (Naieo-Iaoa?ao?a, 1999);
ia V ccae? oa?iaoeaao?a Oe?aie

Ioae?eaoe??. Ca oaiith eaiaeeaeaonueei? aeena?oaoe?? iioae?eiaaii 8
iaoeiaeo ?ia?o. Na?aae ieo 6 noaoae a iaoeiaeo aeo?iaeao (c ieo
2-naiino?eii), 2 oace aeiiia?aeae a iaoa??aeao iaoeiai-i?aeoe/ieo
eiioa?aioe?e.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia
149 noi??ieao oa neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, iaoiae?a
aeine?aeaeaiiy, 5 aeaa aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a,
nieneo e?oa?aoo?e oa aeiaeaoeo. ?iaioa aeeth/a? 32 oaaeeoe?, 1 ?enoiie
oa 12 i?e?ioioia?ao?e. A?ae?ia?ao?y i?noeoue 200 iaeiaioaaiue ?ia?o, c
yeeo 126 a?o/eciyieo oa 74 ?iicaiieo aeaea?aea.

INIIAIEE CI?NO ?IAIOE

Ia’?eoe oa iaoiaee aenia?eiaioaeueieo aeine?aeaeaiue. Ia`?eoaie
oa?iaeieia?/ieo aeine?aeaeaiue aoee: aae? “Ei?aaea?i” oa “Ei?ecai” o
ii??aiyii? c oaaeaoeaie “Ei?aoaaeei”, aeaioiaeaieie ia iniia?
noanoaioe?? ei?aoaaeeio o??ie CHEMO IBERICA S. A. (?niai?y).

“Ei?ecai” canoiniaoaaee ?io?aiacaeueii. A yeino? i?aia?aoa ii??aiyiiy
aeei?enoiaoaaee oaaeaoee “Ei?aoaaeei”, oaaeaoee Terfed-60 (o??ia “Cipla”
LTD, ?iae?y), Aeeiaae?ie (Aeeiaae, ?in?y)- i?e ia?i?aeueiiio aaaaeaii?;
i?e aea/aii i?noeaai? ae?? – i?aia?ao Aea?aiaeee (Asta Medica,
I?ia//eia) o aeaeyae? aa?icieth aeey ?icieeaiiy a iinia? oiaee.

“Ei?aaea?i” iaiineee ia o?aaeaio ae?eyieo oe??e. A yeino? i?aia?aoo
ii??aiyiiy aeei?enoiaoaaee oaaeaoee “Ei?aoaaeei”, oaaeaoee Terfed-60
(o??ia “Cipla” LTD, ?iae?y), Aeeiaae?ie (Aeeiaae, ?in?y)- i?e
ia?i?aeueiiio aaaaeaii?; i?e aea/aiiy i?noeaai? ae?? – i?aia?ao
Oaienoee-aaeue (Zyma, Oaaeoea??y ).

A aeine?aeaeaiiyo ii aea/aiith i?ioeaea?a?eii? ae?? iiaeo e?ea?nueeeo
oi?i a?aeoai?thaaeenue iiaeae? aea?a?/ieo ?aaeoe?e (aiao?eaeoe/iiai)
“iaaaeiiai” oa “oiia?eueiaiiai” oeia ia ii?nueeeo naeieao oa aeeo uo?ao.

Noaia naineaecaoe oa aaaaeaiiy i?aia?aoa i?eaaaeai a oaae.1.

Ioe?ieo oa?iaeieia/ii aeoeaiino? aaea “Ei?aaea?i” oa “Ei?ecai” oa
?ioaineaiino? aea?a?/ieo ?aaeoee i?iaiaeeee c aeei?enoaiiyi iaoiae?a, ui
aeyaeythoue iciaee ?icaeoeo aea?a?/iiai i?ioeano in vivo oa in vitro.

Aiaoeaeoe/io aeoeainoue ioeiaaee ca iaoiaeii caaaeueii aiaoeaen (A.A.
Aacaiia, 1995), aeoeaii oe??ii aiao?eaen? oa ?aaeoe? iai?yii?
aeaa?aioeyoe?? oeaieiieo aacio?e?a (?IAeOA) ? i?iaiaeeee ia
naineaeciaaieo ii?iaeueiith eiiy/ith ne?iaaoeith (IEN) ii?nueeeo naeieao
(E. Eaaa?, 1990).

Aeey a?aeoai?aiiy aenia?eiaioaeueiiai aea?a?/iiai ?ei?oo-?aaeoe??
“oiia?eueiaiiai” oeio, oaa?ei nainea?e?coaaee 2,4-aeei?o?ioei?aaicieii
(AeIOA) ca iaoiaeii (Ae.?. Caaieioiee, 1977). Ioe?ieo oa?aiaaoe/ii?
aoaeoeaiino? aaey “Ei?ecai” oa i?aia?aoa ii??aiyiiy i?iaiaeeee oeyoii
aecia/aiiy ae?aaeaiino? caiaeueii? ?aaeoe?? neeciai? iaieiiee iina (A.N.
?aaai oa ni?aaao., 1970), aecia/aiiy e?eueeino? ?ioiieiiiaoaioieo ee?oei
o cieaao c iino o i?aeaeine?aeieo oaa?ei (A.N. I?aia?aaeainueeee oa
ni?aaao., 1969; A. ?iae?eaaoe, 1986) oa ca aeiiiiiaith i?iaieaoe?eiiai
iacaeueiiai oanoo (A.N. A?oneeianueeee, 1974).

Aeey a?aeoai?aiiy aenia?eiaioaeueiiai aea?a?/iiai eiioaeoiiai
aea?iaoeoo (AEAe) – ?aaeoe?? “oiia?eueiaiiai” oeio, oaa?ei
nainea?e?coaaee AeIOA ca iaoiaeii (I.I. Caeeai, A.A. Eaaeaaa, 1965).
Niaoeeo?/io oa?iaeieia?/io aeoeai?noue aaey “Ei?aaea?i” aea/aee ca
aioeaea?a?eiith oa i?ioecaiaeueiith ae??th. Aoei aeei?enoaii: iaoiae
iaoe??ieo aie?eaoe?e, i?iaa i?noeaai? eaeeioeeoa?ii? ?aaeoe??
(Eoi/einean TH.E., 1972).

Aea/aiiy a?io?i?/ieo iieaciee?a aeeth/aei aecia/aiiy eiioeaio?aoe?e
a?noai?io oa na?ioii?io o e?ia? ? oeaieiao eaaai?a, oe??e oa neecia?e
iino (A.A. Iaiueoeeia, 1987); aecia/aiiy eaeeio?e?i?a (EO) A4, EO N4 oa
EO A4 a e?ia? ? oeaieiao (iaa?? o??ie “NEOGEN Corporat?on”, NOA,
eaai?aoi?iee eiiieaen “N?ea?-?ioii”).

Aeey i?aeoaa?aeaeaiiy io?eiaieo aoaeo?a aaea c Ei?aoaaeeiii i?iaiaeeee
iaoiii?oieia?/ia aeine?aeaeaiiy oeaieie eaaai?a, oe??e ? neeciai?
iaieiioe? iina (A.A. Ia?eoeia, 1969).

Oaaeeoey 1

NOAIA NAINEAIEICAOeII OA AAAAeAIIss I?AIA?AOIA

Aeine?aeaeaiiy oa?iaeie?iaoeee oa a?iaeinooiiino? Ei?aoaaeeio i?iaiaeeee
iaoiaeii ??aeeiii? o?iiaoia?ao?? (E.A. Aeaaeeiaa oa ni?aaao., 1999)

Io?eiai? ?acoeueoaoe ia?iaeaii iaoiaeii aa??aoe?eii? noaoenoeee ca
aeiiiiiaith e?eoa??th Nouethaeaioa (TH.E. Eaaiia, 1990)

Onueiai a aenia?eiaioao aoei aeei?enoaii 30 e?ie?a ii?iaee Oeioeea, 220
ii?nueeeo naeiie oa 50 aeeo uo??a.

?ACOEUeOAOE AeINE?AeAEAIIss OA ?O IAAIAI?AIIss

1. Aeine?aeaeaiiy oa?iaeie?iaoeee Ei?aoaaeeio a i?aai?ci? a caeaaeiino?
a?ae oeyoo aaaaeaiiy. ?acoeueoaoe aeine?aeaeaiue oa?iaeie?iaoeee
Ei?aoaaeeio (iae. 1.) i?ney aaaaeaiiy eiai o ?cieo e?ea?nueeeo oi?iao
na?ae/aoue i?i ?ica?aeiino? a i?ioeanao aniieooaaiiy, ?iciiae?eo oa
ae?i?iaoe?? a caeaaeiino? a?ae oeyoo aaaaeaiiy. Aaeiinia aiaeinooiinoue
aeey io?aiacaeueiiai oeyoo aaaaeaiiy aoea 110%, aeey o?ainaea?iaeueiiai
oeyoo – 70%. Ia iae. 1 aeaeii, ui iaeaeueo aenieee ?aaiue ei?aoaaeeio o
e?ia niinoa?aaany i?e canoinoaaii iacaeueiiai aaeth-1,27iea/ie; aeey
oaaeaoie “Ei?aoaaeei”-1,04iea/ie- /a?ac aiaeeio iney aaaaeaiiy;
oa?iaeieeiaoea o?ainaea?iaeueiiai aaeth-noooai aae?ciyeany –
iaeneiaeueiee ?aaiue Ei?aoaaeeio niinoa?aaany /a?ac 4 aiaeeie neeaaeaa
0,64iea/ie.

Canoinoaaiiy i?aia?aoo o oi?i? aaey ?io?aiacaeueii ca aeaieie
oa?iaeie?iaoeee iiae?aia c aeei?enoaiiyi oaaeaoie, aea noai?th?
aeiaeaoeia? ia?aaaae, ui iieyaathoue o oaeaeeiio ? aaciina?aaeiueiio
aoaeo? o i?noe? aaaaeaiiy, o a?eueo aenie?e a?iaeinooiiino? oe???
e?ea?nueei? oi?ie oa i?ieiiaiaaiino? ca ?aooiie aeueo iecueei?
oaeaeeino? aeaaaeaiiy.

?en. 1. Eiioeaio?aoeey Ei?aoaaeeia a ieacia e?iae e?ieeeia.

Iaicia/aiey: 1 – aaeue “Ei?ecai”; 2 – aaeue “Ei?aaea?i”; 3 – oaaeaoee
“Ei?aoaaeei” .

Ei?aoaaeei o oi?i? o?ainaea?iaeueiiai aaeth a?eueo iieacaiee i?e
oa?ai?? o?ii?/ieo aea?a?/ieo noai?a, oiio ui ?c an?o aeine?aeaeaieo oi?i
ia? iaea?eueo iecuee? cia/aiiy eiinoaio aniieooaaiiy, ?iciiae?eo oa
ae?i?iaoe??. Oiaoi oee?eoeyoe?y o neoaiiiio e?iaiia?ao i?aia?aoa i?e
oeueiio oeyoo aaaaeaiiy aeyaeeany iaea?eueo o?eaaeith.

Aecia/ai? a ?iaio? iniaeeaino? oa?iaeie?iaoeee Ei?aoaaeeio,
aeei?enoaiiai o oi?i? oaaeaoie, o?ainaea?iaeueiiai aaey aai iacaeueiiai
aaey, a?aee?eaathoue iia? iiaeeeaino? aeey aeeoa?aioe?eiaaiiai
canoinoaaiiy oeueiai i?aia?aoo i?e ??cieo aa??aioao aea?a?/ieo
caoai?thaaiue, aeacothoue ia ia?niaeoeai?noue noai?aiiy iiaeo
e?ea?nueeeo oi?i Ei?aoaaeeio aeey oe?eani?yiiaaiiai oa iioeiaeueiiai
eiai aeei?enoaiiy. Oe? iniaeeaino? oa?iaeie?iaoeee oa a?iaeinooiiino?
aeaee i?aenoaae i?eionoeoe iayai?noue iaiaeiaeiai? oa?iaeieia?/ii?
aeoeaiino? e?ea?nueeeo oi?i Ei?aoaaeeio.

2.Aeineaeaeaiiy ii iaa?oiooaaiith iioeiaeueii eiioeaio?aoe Ei?aoaaeeio a
eea?nueeeo oi?iao oa oiiaii-oa?aiaaoe/ieo aeic. Aeineaeaeaii aae c
aeth/ith ?a/iaeiith Ei?aoaaeei o eiioeaio?aoe 0,1%, 0,5% 1% aeey
aea?iaoieia oa 0,05%, 0,2% 0,5% aeey ioi?eiiea?eiaieia. I?e aea/aii
i?ioeaea?a/ii, i?ioecaiaeueii oa aioeanoaiiii aeoeaiino aaea c
Ei?aoaaeeiii anoaiiaeaia eieia caeaaeinoue “eiioeaio?aoey-aoaeo”. Aaeue
aeey oe?e, ui aiuo 1% Ei?aoaaeeio, oa aaeue aeey neeciai iaeiiee iino,
ui aiuo 0,5% Ei?aoaaeeio, aieiaethoue iaeaeueo ae?aaeaiei oa?aiaaoe/iei
aoaeoii.

I?e aea/aii i?ioeaea?a/ii oa aioeanoaiiii ae oaaeaoie “Ei?aoaaeei”
anoaiiaeaii aoaeoeaia aey oaaeaoie a aeic 1ia/ea (aeiaiaa aeica
ethaeeie). Niaoeeo/ia aeoeainoue aaeth aeey aea?iaoieia
aeineaeaeoaaeanue o aeic 5ia/ea, ai o?ainaea?iaeueia oi?ia i?aia?aoo
canoiniaooueny a aeic?, ui ia?aaeuothoue oaaeaoiaai a na?aaeiueiio a
5-10 ?aca (R.C. Wester, H.I. Maibach, 1983). Caaeii c ?acoeueoaoaie
aea/aiiy oa?iaeieiaoeee aaaaeaiiy iacaeueiiai aaeth i?iaiaeeeinue a oe
aea aeic, ui oaaeaoie–1ia/ea (iaeneiaeueia eiioeaio?aoey Ei?aoaaeeio a
e?ia niinoa?aaeany i?e canoinoaaii iacaeueiiai aaeth-1,27iea/ie; aeey
oaaeaoie “Ei?aoaaeei”-1,04iea/ie-/a?ac aiaeeio iney aaaaeaiiy).

3. Aea/aiiy niaoeeo?/ii? i?ioeaiao?eaeoe/ii? ae?? aaea “Ei?aaea?i” oa
“Ei?ecai” o ii??aiyii? c i?ioeaea?a?/ieie i?aia?aoaie 1-ai oa 2-ai
iieie?iiy. Anoaiiaeaii, ui aie?eaoe? aaey “Ei?aaea?i” ? aaaaeaiiy
?io?aiacaeueii aaey “Ei?ecai” ii?nueeei naeieai, nainea?e?ciaaiei IEN,
cieaeoaaee nooi?iue aiao?eaeoe/iiai oieo. Oaeee aoaeo i?aia?ao?a
aeaiiino?o? ?o i?ioeaiao?eaeoe/io aeoeai?noue ia iiaeae? aea?aiiaoieia??
– aiao?eaeoe/iee oie (aea?a?/ia ?aaeoe?y “iaaaeiiai” oeio). O iaeeiaaieo
oaa?ei iney aaaaeaiiy caaa?oaeueii aeice ioaineainoue aiaoeaeoe/iiai
oieo aeinyaaea 100% (caaeioei 100% oaa?ei). I?e canoinoaaii aaea
“Ei?aaea?i” e “Ei?ecai” e i?aia?aoa ii?aiyiiy oaaeaoie “Ei?aoaaeei” a
aeicao 5ia/ea, 1ia/ea e 1ia/ea aaeiiaaeii (oaae.1), aaei/aoueny
aeecueeee oa?aiaaoe/iee aoaeo 82,5%;85% e 82,5% aaeiiaaeii.

Canoinoaaiiy i?ioeaea?a/iiai i?aia?aoo Oa?oaiaaeei a iiaeae
aiaoeaeoe/iiai oieo iacia/ii iinooiaoueny ca aoaeoeainoth ae a aeic
4ia/ea (78%). Oa?aiaaoe/ia aoaeoeainoue Aeeiaae?ieo aeinyaaea a aeic
2ia/ea (58%).

Aoei aea/aii ni?iiiaei?noue ?io?aiacaeueiiai oa o?ainaea?iaeueiiai aae?a
ci?iaoe i?noeaa? i?iyae aiao?eaeoe/ieo ?aaeoe?e a iiaeae aeoeaii eiaeii
aiaoeaen (AEA), yea iaeaaeeoue aei aiao?eaeoe/ieo ?aaeoe?e, ui iathoue
i?noeaa? i?iyae. Aiia aaco?oueny ia iaoai?ci? i?aeaeuaii? i?iieeeeaino?
eai?ey??a. Ci?ie, ui niinoa??aaeenue a aenia?eiaio?, iiae?ai? aei
i?iya?a ae?acii? aea?a?/ii? aeneiee o ethaeeie. ?acoeueoaoe ?aaeoe??
AEA i?iaeaiiino?oaaee aoaeoeai?noue aaea “Ei?aaea?i” oa “Ei?ecai” i?e
aiao?eaeoe/i?e ?aaeoe?? “iaaaeiiai” oeio, ui aeyaeyeany i?noeaai. I?e
ii??aiyii? ?acoeueoao?a AEA, i?ney aaaaeaiiy aaey “Ei?aaea?i” ? oaaeaoie
Oa?oaiaaeeio niinoa??aaany iaeiaeiaee ca ae?aaeai?noth oa?aiaaoe/iee
aoaeo -70%, i?ney aaaaeaiiy aaey “Ei?ecai” – 90%. A oie /an ye i?e
aeei?enoaii? oaaeaoie “Ei?aoaaeei” aoaeo aeinyaaa 80%, a oaaeaoie
Aeeiaae?ie – 60%.

C iaoith aecia/aiiy caeaoiino? aaea “Ei?aaea?i” oa “Ei?ecai” cieaeoaaoe
o ii?nueeeo naeiie noai a?ia?/ooeeaino?, ui ?icaeaaany a ?acoeueoao?
nainea?e?caoe?? IEN, aoei aeei?enoaii ?aaeoe?th iai?yii? aeaa?aioeyoe??
oeaiueiaeo aacio?e?a (?IAeOA). Nainea?e?c?oe?y ii?nueeeo naeiie IEN
ni?ey? ?iaeoeoaaiith a i?aai?ci? neioaco niaoeeo?/ieo aioeo?e, ye?
iiaeooue noai?thaaoe ?ioii? eiiieaene, ui aea??eiai a?aaeathoue
ee?oeie-i?oai?. ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue iieacaee, ui o
nainea?e?ciaaieo ii?nueeeo naeiie (“iae?eiaaieo”) iieaciee ?IAeOA
aeoiaeea ca iaae? ii?ie-0,240,06 ( ii?ia-0,20). O a?oiao oaa?ei, ye?
io?eioaaee aaeue “Ei?aaea?i” oa i?aia?aoe ii??aiyiiy 2-ai iieie?iiy –
oaaeaoee Oa?oaiaaeei ? “Ei?aoaaeei”, iieaciee ?IAeOA a?aeiiaethaaany aei
ii?ie o 80% oaa?ei, “Ei?ecai” – o 90% oaa?ei. O a?oi? oaa?ei, ui
io?eioaaee oaaeaoee Aeeiaae?ie, iieaciee ?IAeOA a?aeiiaethaaany o 60%
oaa?ei. I?e oeueiio aeei?enoaiiy e?ea?nueeeo oi?i c Ei?aoaaeeiii ca oiia
??cieo oeyo?a aaaaeaiiy aeaiiino?o? ia?aaaao ?io?aiacaeueiiai aaey
“Ei?ecai”. Oa?iaeioa?aiaaoe/ia aeoeai?noue aaey “Ei?aaea?i” o ?IAeOA ia
a?ae??ciyeany a?ae oaei? o i?aia?ao?a ii??aiyiiy – “Ei?aoaaeei” oa
Oa?oaiaaeei, ? ia?aaeuoaaea aeoeai?noue Aeeiaae?ieo.

Ie??i aieeao ia ciai?oi? i?iyae caaaeueii? oa i?noeaai? ?aaeoe??
aiao?eaen?? aeine?aeaeai? aae? c Ei?aoaaeeiii ni?aaeythoue
oa?iaeieia?/iee aieea ia aea?eueiaiiy iecee iaae?aoi??a (a?noai?i,
na?ioii?i, eaeeio???ie).

I?iaaaeaia aeine?aeaeaiiy aeyaeei aioea?noai?iio aeoeai?noue aea/aieo
i?aia?ao?a (oaae.2).

Oaaeeoey 2.

Aieea aaeae “Ei?aaea?i” oa “Ei?ecai” ia eiioeaio?aoe?th a?noai?io o
e?ia? ? oeaiei? eaaai?a

o ii?nueeeo naeiie i?e aiao?eaeoe/iiio oioe? (n=10; M + m)

Oiiae aeineaeoEiioeaio?aoey anoaiioa e?ia, iea/ie a eaaaiyo, iea/100 ia
Iioaeoi oaa?eie5,1 + 0,619,5 + 2,2IEN (“iaeeiaai”)8,1 + 0,7**41,5 +
3,4**IEN + “Ei?aaea?i”5,6 + 0,4*21,6 + 2,3*IEN + “Ei?ecai”5,2 + 0,3*19,8
+ 2,6*IEN + “Ei?aoaaeei”5,4 + 0,3* 20,7 + 2,0*I?eioee:

1. IEN – naineaecaoey

2. * -? “Ei?aoaaeei” >
“Ei?aaea?i”.

Aeai aeineaeaeaiue cinoo na?oiiio o e?ia oa eaaaiyo aeeo uo?a
aae?ciyeeny a “eeiaaieo” oa “iaeeiaaieo” a?oiao oaa?ei. O “iaeeiaaieo”
oaa?ei niinoa?aaee aeinoia?ia cieaeaiiy na?ioii?io (ia 58%) o eaaaiyo
aaeiinii ioaeoiiai eiio?ieth, iaeii/anii cino na?ioiiio a ieaci e?ia ia
ciithaaany. A a?oi “eeiaaieo” oaa?ei niinoa?aaeanue ii?iaecaoey
eiioeaio?aoe na?ioiiio a eaaaiyo.

I?e ?icaeoeo aino?iai aiao?eaeoe/iiai oieo eiioeaio?aoe?y EO A4, EO A4
aeinoia??ii ca?eueoeeany ye o ne?iaaooe? e?ia? – 3,5 1,6 ?ace (?
aioo?oiueioeoieiai > o?ainaea?iaeueii.

3. Ia iiaeaeyo aea?a/ieo (aiaoeaeoe/iee oie, aea?a/iee ?eio, aea?a/iee
eiioaeoiee aea?iaoeo) ?aaeoee “iaaaeiiai” oa “oiiaeueiaiiai” oeia
anoaiiaeaii, ui aoaeoe i?ioeaea?aeii oa i?ioecaiaeueii ae
o?ainaea?iaeueiiai oa iacaeueiiai aaeae c Ei?aoaaeeiii iaoiiaeai iaaoeth
aeaeueiaiiy iaae?aoi?a aea?a – anoaiio, na?ioiiio oa eaeeio?ia A4, N4
oa A4.

4. Iia eea?nuee oi?ie – aae “Ei?ecai” oa “Ei?aaea?i”, ieacothoue inoeaao
neiioiiaoe/io aeth oa iaeii/anii aeyaeythoue eeoaaeueii-i?ioeaeoe/iee
aoaeo. Ii?oieia/ieie aeineaeaeaiiyie anoaiiaeaii iaeaea iiaio
aaenooinoue iciae aiaoeaeoe/iiai oieo o eaaai?ae oeaiei, aea?aeiiai
caiaeaiiy o oe? oa neeciae iaieiioe iino aenia?eiaioaeueieo oaa?ei, yeeo
eeoaaee o?ainaea?iaeueiei oa iacaeueiei aaeyie c Ei?aoaaeeiii.

5. Canoinoaaiiy i?aia?aoa “Ei?ecai” noai?th aeiaeaoeia ia?aaaae, ui
aeyaeythoueny o oaeaeeiio oa aaciina?aaeiueiio aoaeo o inoe aaaaeaiiy,
aeueo aeniee aiaeinooiiino oe eea?nueei oi?ie, i?ieiiaiaaiino ae ca
?aooiie iecueei oaeaeeino aeaaaeaiiy. Oea aeicaiey ?aeiiaiaeoaaoe
canoinoaaiiy iacaeueiiai aaey aeey eoi?oaaiiy aino?eo i?iyaa aea?a/ieo
i?ioeana aa?oio aeeoaeueieo oeyoa oei aeueoa, ui ca nooiaiyie ae?aciino
oa?iaeieia/ieo aoaeoa “Ei?ecai” ia?aaaaea oaaeaoee Oa?oaiaaeeia oa
Aeeiaae?iea: 85%, 78% oa 58% aaeiiaaeii.

6. Ii?aiyeueiee aiaec oa?iaeieia/ii aeoeaiino iieacaa ia?aaaaeaiiy aaea
c Ei?aoaaeeiii iaae i?aia?aoaie-aiaeiaaie aeey inoeaaiai canoinoaaiiy –
aa?icieai Aea?aiaeee Oaienoee-aaeai. Oa?iaeieia/ia aoaeoeainoue
“Ei?ecaio” oa Aea?aiaeeeo aei?aithaaea 90% oa 60% aaeiiaaeii;
“Ei?aaea?io” oa Oaienoee-aaeth – 77% oa 67% aaeiiaaeii.

7. Aae “Ei?aaea?i” oa “Ei?ecai” aoaeoeaieie oa aacia/ieie eea?nueeeie
oi?iaie, ye ai?iaaaeaeaii a iaaee/io i?aeoeeo a yeino i?ioeaea?aeieo,
i?ioecaiaeueieo oa aioeanoaiiieo i?aia?aoa.

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