AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OA?IAEIEIA?? OA OIENEEIEIA??

N?/aiiaa Ieaia A?eoi??aia

OAeE
615.32: 616-084-099: 632.95

AENIA?EIAIOAEUeIA IAA?OIOOAAIIss AEEI?ENOAIIss NEE?AI?O AeEss
I?IO?EAEOEEE ?IOIENEEAOe?? AeEI?O?II?OIE?ACIEII

14.03. 05 — oa?iaeieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
IIC Oe?a?ie

Iaoeiaee ea??aiee: Aeieoi? iaaee/ieo iaoe, i?ioani?,

Eoe’yi/oe A?eoi? Aeieo?iae/,

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?e oa?iaeieia??

Io?oe?ei? iiiiaioe: Aeieoi? iaaee/ieo iaoe, i?ioani?,

O?aioeociaa Noaea Ai?en?aia,

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.
I.I.Aiaiiieueoey,

i.Ee?a.

I?ia?aeia onoaiiaa: Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao

IIC Oe?a?ie, eaoaae?a
oa?iaeieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny “13” aeiaoiy 1999 ?ieo i 13 aiaeei?

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.550.01 i?e ?inoeooo?
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie (252057, Ee?a, aoe. A.Iioue?,
14).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie ( 252057, Ee?a, aoe.A.Iioue?,
14).

Aaoi?aoa?ao ?ic?neaiee “7” aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee Ae26.550.01.,

eaiaeeaeao a?ieia?/ieo iaoe
?.A.Aeaiiaa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Aeiiii?/i? ia?aoai?aiiy, ye? a?aeaoeeny a
Oe?a?i?, a?aeaeeeny ia ??ceiio niaae? aeayeeo aeae?a ae?iaieoeoaa.
Iaeiae, aaeeeee i?iieneiaee ?aa?ii Aeiiaano a?aeiineoueny aei oeo
?aa?ii?a e?a?ie, aea neiioeaio?iaaii ooieoe?iioth/? o?i?/i? caaiaee,
i?iieneia? ia’?aeiaiiy ? oaooe. Iniaeeai o?aaa a?aei?oeoe cia/iee
iioaioe?ae o?i?/iiai ae?iaieoeoaa a Aeiiaanueeiio ?aa?ii?. O?i?caoe?y
i?iieneiaeo aaeocae ia?iaeiiai ainiiaea?noaa ? iiaooo i?ecaiaeeoue aei
o?i?/iiai caa?oaeiaiiy na?aaeiaeua ? na?eicii caa?iaeaeo? caei?ia’th
ethaeae. A inoaii? ?iee a Oe?a?i? iaooeeueii c?inoa? o?i?caoe?y ?
n?euenueeiai ainiiaea?noaa aiane?aeie ?icoe?aiiy ani?oeiaioo ?
e?eueeino? ?a/iaei, cie?aia ianoeoeeaeieo i?aia?ao?a, i?ia?aeueieo
aeia?ea oa ?ioeo, ye? canoiniaothoueny a oe?e aaeoc? ia?iaeiiai
ainiiaea?noaa. Iacaaaeath/e ia oe?ieee eiiieaen i?aai?caoe?eieo ?
nai?oa?ii-a?a??i?/ieo caoiae?a i?e canoinoaaii? cania?a caoenoo ?ineei,
aino?? io?o?iiy ianoeoeeaeaie i?iaeiaaeothoue ?a?no?oaaoeny (A.A.
Iiaeaaa e niaao., 1997).

I?iaaaeaii aiae?c aino?eo io?o?iue ianoeoeeaeaie a Oe?a?i? ca inoaii?
a?n?i ?ie?a. I?e oeueiio a?aecia/athoueny aino?? ye a?oiia?
?ioieneeaoe?? n?euenueeiainiiaea?nueeeo i?aoe?aiee?a, oae ? iaeeie/i?
aeiaaeee, ye? aeieeathoue caeaa?eueoiai i?e ii?ooaii? oa?i?i?a aeoiaeo
ethaeae ia ia?iaeai? iiey, a oaeiae i?aeaeuaii? ii?i aeo?aoe ca oiia
?ioaineaiiai niiy/iiai aei?ii?iaiiy (A.I. Aaeai e niaao., 1998). Na?aae
i?aai?/ieo niieoe, ui oe?iei aeei?enoiaothoueny a i?iieneiaino? ?
n?euenueeiio ainiiaea?noa?, aaaeeeaa i?noea caeiathoue aeeeeiio?aei?
2,4-aeei?o?ioaiieo, cie?aia aeei?o?ii?oie?acie (AeIIE), i?iieneiaee
neioac yeiai ui??/ii c?inoa?. Oae, ia ?oaaaeainueeiio i/i «E?aneoaeue»
ui??/ii neioaco?oueny aeecueei 2200 o oe??? ?a/iaeie ia ??e, yea
a?ae??ciy?oueny oiene/i?noth ? iaaaciaeith aeieeiaiiy ? ?icaeoeo aino?eo
nia?oaeueieo io?o?iue in?a, ui eiioaeoothoue c iath ye a n?euenueeiio
ainiiaea?noa? i?e canoinoaaii? a yeino? o?i?/iiai caniao caoenoo
?ineei, oae ? a oiiaao eiai ae?iaieoeoaa oa aeei?enoaiiy a ??cieo
aaeocyo i?iieneiaino? (?. Iaaio, 1984; E.E. Eioiyioe, 1983 ).

A caaaeuei?e nenoai? i?io?eaeoe/ieo caoiae?a, ye? i?iaiaeyoueny ia
i?iieneiaeo i?aei?e?inoaao ii ae?iaieoeoao oiene/ieo ?a/iaei, /?eueia
i?noea caeiathoue caoiaee, iai?aaeai? ia cieaeaiiy ??aiy iaoieia??
o?i?/ii? ao?ieia??. 0aeiae, i?e iaaeio?eiaii? i?aaee oaoi?ee aaciaee,
aaa??eieo oa ?ioeo aeno?aiaeueieo neooaoe?yo iiaeeea? aino?? io?o?iiy
aeei?o?ioaiieueieie niieoeaie, ui ia??aeei cae?i/othoueny eaoaeueii.

Ine?eueee aaaeeeaith iaaee/iith caaea/ath ? aeine?aeaeaiiy e oieeiaiiy
?aaeueii? ? iioaioe?eii? iaaaciaee o?i?/ieo ?a/iaei aeey caei?ia’y
ethaeae, oi aeooaeueiith i?iaeaiith no/anii? oa?iaeieia?? ? oieneeieia??
? iiia?aaeaeaiiy ? e?eoaaiiy iaoieia?/ieo noai?a, aeeeeeaieo aieeaii ia
i?aai?ci enaiia?ioee?a o?i?/ii? i?e?iaee ??cii? aoaeiae. A oie aea /an a
a?naiae? i?aeoe/ieo e?ea??a iaia? aeinooiieo aenieiaoaeoeaieo ? ?acii c
oei aacia/ieo cania?a i?io?eaeoeee ? e?eoaaiiy aino?eo ? o?ii?/ieo
?ioieneeaoe?e aeei?o?ioaiieueieie niieoeaie, a oiio /ene? ? AeIIE.

Aiae?c aeaieo e?oa?aoo?e iieaco?, ui iioeiaeueiee can?a e?ea?nueei?
i?io?eaeoeee, aeei?enoaiee i?e ?ioieneeaoe?? AeIIE, iiaeiai eiia?ioaaoe
a nia? aeanoeaino? aioeieneaeaioa ? ?iaeoeoi?a iiiiieneaaiacii? nenoaie
ia/?iee (A.Ae. Eoeueyi/oe, 1988). Ca aeaieie A. ?. Aaiaa?ianueeiai oa
ni?aaao. (1987) aei i?aia?ao?a, ui aeyaeythoue oae? oa?iaeiaeeiai?/i?
aoaeoe, a?aeiinyoueny a?ioeaaiii?aee, ye? ca?aeii c ?acoeueoaoaie
aeine?aeaeaiue, ui i?iaiaeeeeny ?ai?oa o eaai?aoi??? eaoaae?e
oa?iaeieia?? Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (EAeIO)
(E.A. Naa/aieiaa, 1991), aeyaeythoue ae?aaeaio aioeieneaeaioio
aeoeai?noue ? caeaoi?noue ?iaeoeoaaoe iiiiieneaaiacio nenoaio ia/?iee ca
oiia aieeao ia i?aai?ci oaeeo aeno?aiaeueieo oaeoi??a, ye ?ioieneeaoe?y,
a?iien?y, ia?aa??a oa ?io?.

Aeeeaaeaia aeua noaei oai?aoe/iei iaa?oiooaaiiyi aeioe?eueiino?
ne?ei?iaiaiai aea/aiiy a?ioeaaiii?ae?a a yeino? iioaioe?eieo
i?io?eaeoe/ieo cania?a ca oiia aino?i? ?ioieneeaoe?? AeIIE ? anaa?/iiai
aeine?aeaeaiiy iaea?eueo aoaeoeaiiai c ieo caniao caoenoo i?e
AeIIE-?ioieneeaoe??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oey ?iaioa
aeeiioaaeany a?aeiia?aeii c ieaiii iniiaieo iaoeiaeo iai?yie?a EAeIO ca
oaiith: “ Oa?iaeieia?/ia ei?aeoe?y iaoaaie?/ieo i?ioean?a i?e
a?iiene/iiio neiae?ii?” (? aea?ae. ?a?no?aoe?? 0195/026228, 1995- 1998
??.). Ie?ai? o?aaiaioe aeine?aeaeaiiy aeeiioaaeeny a ?aieao eiieo?nii?
oaie I?i?noa?noaa iaoee ? oaoiieia?e Oe?a?ie “Aenia?eiaioaeueia ?ic?iaea
oeyo?a iaoiaaiaoe/ii? oa?ai?? ?oai?/ieo noai?a ia iniia? aioea?iienaio?a
oa aaeaioiaai?a” (i?iaeo ? 02.03./01187,
1997-1998 ??.), a oaeiae ia i?ioaiiy aaei?i?no?aoe?? ?oaaaeainueeiai
i?iieneiaiai ia’?aeiaiiy “E?aneoaeue” (eeno ? 1/734 a?ae 20.03.1996
?.).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei oai?aoe/ia oa
aenia?eiaioaeueia iaa?oiooaaiiy aeioe?eueiino? aeei?enoaiiy nee?ai?o i?e
i?io?eaeoe/iiio eiai aaaaeaii? ca oiia aino?i? ?ioieneeaoe?? AeIIE.

Aeey aeinyaiaiiy iinoaaeaii? iaoe i?iiiioaaeiny ae??oeoe oae? caaaeaiiy:

1. ?ic?iaeoe aenia?eiaioaeueio iiaeaeue aino?i? ?ioieneeaoe?? AeIIE
eaai?aoi?ieo oaa?ei, i?iaanoe ne?ei?ia cania?a e?ea?nueei? i?io?eaeoeee
na?aae a?ioeaaiii?ae?a ca aeaieo oiia aenia?eiaioo, a oaeiae ?ic?iaeoe
iioeiaeueiee aeiciaee ?aaeei i?io?eaeoe/iiai aaaaeaiiy iaea?eueo
aoaeoeaiiai a?ioeaaiii?aea.

2. Aea/eoe aieea nee?ai?o, canoiniaaiiai c i?io?eaeoe/iith iaoith, ia
iniiai? ia?aiao?e oieneeie?iaoeee AeIIE a a?ina?aaeiaeuao i?aai?cio.

3. Aeine?aeeoe ooieoe?iiaeueiee noai iiiiieneaaiacii? nenoaie ia/?iee
i?e ?ioieneeaoe?? AeIIE ? i?io?eaeoe/iiio aaaaeaii? nee?ai?o.

4. Aea/eoe aieea nee?ai?o ia e?iaoeeo a?eueii?aaeeeaeueieo ?aaeoe?e a
a?ina?aaeiaeuao i?aai?cio, a oaeiae ai?no eeth/iaeo i?iaeoeo?a
e?i?aeia?aieeneaiiy ? noai aioeieneaeaioii? nenoaie i?aai?cio a
aeeiai?oe? i?e aino??e (EAe50) AeIIE- ?ioieneeaoe??.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. A ?iaio? aia?oa oai?aoe/ii
iaa?oioiaaia ? aenia?eiaioaeueii i?aeoaa?aeaeaia aeioe?euei?noue ?
aoaeoeai?noue canoinoaaiiy a?ioeaaiii?aeo nee?ai?o, a oaeiae ?ic?iaeaiee
iioeiaeueiee aeiciaee ?aaeei eiai canoinoaaiiy a yeino? i?io?eaeoe/iiai
caniao i?e ?ioieneeaoe?? iaeiei c iaea?eueo oiene/ieo aeeeeueieo
iio?aeieo 2,4-aeei?o?ioaiieo — AeIIE. Aenia?eiaioaeueii aeiaaaeaii, ui a
iniia? iaoai?cio caoenii? ae?? nee?ai?o i?e aeei?o?ii?oie?acieuei?e
?ioieneeaoe?? eaaeeoue ni?iiiaei?noue a?ioeaaiii?aea ?ia?aoaaoe i?ioeane
e?i?aeia?aieeneaiiy a a?ina?aaeiaeuao aaea ia aoai? ?i?oe?aoe??
a?eueii?aaeeeaeueieo ?aaeoe?e c ianooiiei ?noioiei cieaeaiiyi ??aiy
ia?aeiieo oa aoi?eiieo i?iaeoeo?a ia?aeeniiai ieeneaiiy e?i?ae?a (IIE) c
iaeii/aniith ?aae?caoe??th i?ioaeoi?ii? ae?? o a?aeiioaii?
aioeieneaeaioii? oa iiiiieneaaiacii? nenoai caoenoo i?aai?cio.
Anoaiiaeaia ni?iiiaei?noue a?ioeaaiii?aeo iiaeeo?eoaaoe oieneeie?iaoeeo
AeIIE oeyoii i?enei?aiiy eiai ae?i?iaoe?? oa aene?aoe?? c na/ath.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Ia iniia? i?iaaaeaieo
aenia?eiaioaeueieo aeine?aeaeaiue ?ic?iaeaii oa iaae?oeiaaii “Iaoiaee/i?
?aeiiaiaeaoe?? ii canoinoaaiith iaoiaeo a?ioai?ethi?ianoeaioe?? o
oa?iaeieia??” (AII Oe?a?ie, IIC Oe?a?ie, Eoaainuee, 1997).

?acoeueoaoe ie?aieo o?aaiaio?a aeine?aeaeaiiy ai?iaaaeaeaii a i?aeoeeo
ioi?iie caei?ia’y ? ?iaioo iaoeiaeo onoaiia o oi?i? ?ioi?iaoe?eiiai
eenoa “Iioei?caoe?y oa?iaeioa?ai?? nee?ai?ii io?o?iiy
aeei?o?ii?oie?acieii” (Eoaainuee, 1998).

Iniiai? ?acoeueoaoe aeine?aeaeaiue, ye? a?aeia?aaeathoue aeioe?euei?noue
canoinoaaiiy nee?ai?o i?e oiene/ieo aaiaoeoao, ai?iaaaeaeaii a ?iaioo
oieneeieia?/iiai a?aeae?eaiiy Eoaainueei? iaeanii? ee?i?/ii? e?ea?i?,
aano?iaioa?ieia?/iiai a?aeae?eaiiy i. ?iaaiueee, eaoaae?e aini?oaeueii?
oa?ai?? ?2 EAeIO, a?aeae?eaiiy ?aai?iaoe?? oa ?ioaineaii? oa?ai??
i?nueei? ee?i?/ii? e?ea?i? ?3 i. Eoaainueea.

Iaoa??aee aeine?aeaeaiue aeei?enoiaothoueny a iaa/aeueiiio i?ioean? ia
eaoaae?ao oa?iaeieia?? ?aaii-O?aie?anueei? oa Aei?i?iiao?ianueei?
aea?aeaaieo iaaee/ieo aeaaeai?e, Eoaainueeiai oa Iaeanueeiai aea?aeaaieo
iaaee/ieo oi?aa?neoao?a, a oaeiae a iinoaeeieiii?e i?aeaioiaoe?
i?ia?ci??a i?e Eoaainueeiio iaeaniiio eiioiaeueiiio ae?iaie/iio
i?aei?e?inoa? “Oa?iaoe?y”.

Ca iaoa??aeaie aeine?aeaeaiue i?aeaioiaeaia oa iiaeaia o IAeOeIA Oe?a?ie
cayaea ia aeiao?ae “ Can?a aeaoieneeaoe?? aeei?o?ii?oie?aciea”
(?a?no?aoe?eiee ? 99010401 a?ae 26.01.1999 ?.), a oaeiae io?eiaii 2
iina?ae/aiiy EAeIO ia ?aoe?iiae?caoi?nuee? i?iiiceoe?? (? 3008 a?ae
14.03. 96 ?., ? 3145 a?ae 29.10. 98?).

Io?eiai? a ?iaio? aeai? aeei?enoaii i?e ieaioaaii? a?aeii/i? oaie a
?inoeooo? a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie ?
2.1.10.18 “O?ceei-o?i?/iee, iieaeoey?ii-a?ieia?/iee ? iaoaiaoe/iee
aiae?c iaea?eueo caaaeueieo ?en aca?iiae?? OA? c a?iiae?iiieaeoeaie”
(1998-2000 ??.) a /anoei? iiooeo caeaaeiino? i?ae o?i?/iith aoaeiaith ?
oa?iaeieia?/iith aeoeai?noth a?ioeaaiii?ae?a, a oaeiae ia eaoaae??
oa?iaeieia?? EAeIO i?e ieaioaaii? IAe? ia 1999-2003 ??. ca oaiith:
“Aenia?eiaioaeueia ?ic?iaea cania?a oa?iaeiei?aeoe?? aeno?aiaeueieo
noai?a i?aai?cio” (? aea?ae. ?a?no?aoe?? 0198U009100).

?acoeueoaoe aeine?aeaeaiue iiaeooue aooe iieeaaeai? a iniiao ieaioaaiiy
IAe? a iaeano? neioaco iiaeo i?aai?/ieo niieoe ye iioaioe?eieo
aioeaeioii-e?eoaaeueieo cania?a ? neoaeeoe aenia?eiaioaeueiei
iaa?oiooaaiiyi aeey iiaeaeueoeo aeine?aeaeaiue o aaeoc? iioei?caoe??
e?eoaaiiy oa i?io?eaeoeee aino?eo io?o?iue o?i?/ieie ?a/iaeiaie.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii i?iaaaeaii
iaoaioii-?ioi?iaoe?eiee iiooe. A i?ioean? iaea?aeaiiy ?acoeueoao?a
iaoeiaeo aeine?aeaeaiue, aeeeaaeaieo a aeena?oaoe?ei?e ?iaio?, iaienaiiy
iaeyaeo e?oa?aoo?e, an? aeaee aenia?eiaioaeueieo ?ia?o caeiaoaa/ai
i?iaaaeaii naiino?eii. Noaoenoe/ia ia?iaea, ocaaaeueiaiiy oa aiae?c
io?eiaieo aeaieo, ioi?ieaiiy ?o o aeaeyae? oaaeeoeue oa a?ao?e?a, a
oaeiae ?ic?iaea iniiaieo iieiaeaiue oa aeniiae?a c?iaeaii aeena?oaioii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? o?aaiaioe ?iaioe
aeiiia?aeaee ia International conference Environmental and Occupational
Health and Safety in Agriculture on the Boundary of Two Milllennia
(Eiav, 1998 y.), i?aeia?iaei?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeooaeuei? i?iaeaie aeia?a??ie ? oieneeieia??” (Ee?a, 1998 ?.), VI
eiia?an? i?aeia?iaeii? oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo oiaa?enoa
(Iaeana, 1996 ?.), , II Oe?a?inuee?e iaoeia?e eiioa?aioe?? c
i?aeia?iaeiith o/anoth “Aeooaeuei? i?iaeaie ee?i?/ii? oa?iaeieia??”
(A?iieoey, 1998 ?.), iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e
100-??//th c? aeiy canioaaiiy 4-i? i?nueei? e?ea?i? i. Eoaainueea
(Eoaainuee, 1995 ?.), a oaeiae ia can?aeaii? Eoaainueeiai a?aeae?eaiiy
Oe?a?inueeiai iaoeiaiai oiaa?enoaa oa?iaeieia?a (Eoaainuee, 1997, 1998
??.).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 11 iaoeiaeo ?ia?o, c
ieo 3 noaoo? a iaoeiaeo aeo?iaeao, 1 – a ca??oe? iaoeiaeo i?aoeue, 1
iaoiaee/i? ?aeiiaiaeaoe??, 1 ?ioi?iaoe?eiee eeno.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 124
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, iaoa??ae?a ? iaoiae?a aeine?aeaeaiiy, o?ueio ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a oa nieneo aeei?enoaieo
aeaea?ae. ?iaioo i?i?ethno?iaaii 13 oaaeeoeyie, 10 iaethieaie.
A?ae?ia?ao?y i?noeoue 122 a?o/eciyi? oa 100 ?iicaiieo aeaea?aea.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. Aeine?aee i?iaaaeaii ia 940 a?eeo
uo?ao noaaeiiai ?icaaaeaiiy, a oaeiae ia uo?ao e?i?? A?noa? ianith
160-220 a iaio noaoae, yeeo oo?eioaaee ia caaaeueiiio ?aaeei? oa?/oaaiiy
a?aa??th EAeIO. Aeey aeine?aeo oaa?ei a?aee i?ney i?ioiaeaeaiiy
ea?aioeio i?ioyaii 14 aei?a.

Aenia?eiaioaeueiith iiaeaeeth neoaoaaa iaoieia?/iee i?ioean, ui
?icaeaa?oueny o oaa?ei i?e aioo??oiueioeoieiaiio aaaaeaii? 1% aiaeiiai
?ic/eio iao???ai? nie? AeIIE a ??cieo aeicao, aea caeaa?eueoiai a
aeicao, a?aeiia?aeieo na?aaeiueinia?oaeueiei (EAe50). Iiaeaethaaiiy
aino?i? AeIIE-?ioieneeaoe?? i?iaiaeeee c o?aooaaiiyi aeaieo, io?eiaieo
?ai?oa a ?iaio? A.Ae. Eoe’yi/oea (1988). O yeino? ?ic/eiieea AeIIE
aeei?enoiaoaaee aiaeo aeenoeeueiaaio. Uo?ai ?ioaeoii? a?oie aaiaeeee
a?aeiinii eiio?ieth aaeaeaaoio e?euee?noue aeenoeeueiaaii? aiaee.

Aeey ne?ei?iao aeei?enoiaoaaee oaaeaoiaai? oi?ie a?ioeaaiii?aeieo
i?aia?ao?a (oeai?i, oeaeoi?i, eiiaaoeaa?i, eaa?oeaoei, nee?a?i?i,
nee?ai?) o aeaeyae? iaeieoaeieo ?ic/ei?a. A ?iaio? canoiniaoaaee nee?ai?
ia o?eueee o oaaeaoiaai?e e?ea?nuee?e oi?i? ae?iaieoeoaa Oa?e?anueei?
oa?iaoeaaoe/ii? o??ie “Caei?ia’y”, a e o aeaeyae? noanoaioe??.

I?e aecia/aii? iioeiaeueiiai aeiciaiai ?aaeeio canoinoaaiiy nee?ai?o ca
oiia iaoieia?? o?i?/ii? ao?ieia?? i?aia?ao aaiaeeee ia?i?aeueii o
aeaeyae? 1% iaeieoaeiiai aiaeiiai ?ic/eio a aeicao: 30, 165, 300 ia/ea a
??ciee /an: ca 30, 75 oa 120 oaeeei (eiaeia aeica a?aeiia?aeii) aei
aaaaeaiiy AeIIE (EAe50 oa a?eueoa). I?io?eaeoe/io aoaeoeai?noue
e?ea?nueeeo cania?a, ye? aea/aeeny i?e ne?ei?iao, ? aeic nee?ai?o
aecia/aee ye ??cieoeth i?ae a?aenioeii aeaeeaaiiy a a?oi? oaa?ei, yeei
aaiaeeee i?aia?ao, ? aeaeeaaiiyi a a?oi? aac eiai aaaaeaiiy (eiio?ieue),
ca ia?aa?aii ee?i?/ii? ea?oeie ?ioieneeaoe?? a aeeiai?oe? oa no?ieao
caaeaae? oaa?ei a?ae iiiaioo iaaeoiaeaeaiiy ianoeoeeaeo aei i?aai?cio.
Iioeiaeueio i?io?eaeoe/io aeico nee?ai?o ?ic?aoiaoaaee a?ao?/ii o
eii?aeeiaoao “aeica — aoaeo” ? “/an-aoaeo”.

I?e i?iaaaeaii? oieneeiiao?e/ieo aeine?aeaeaiue, a oaeiae aecia/aii?
?iaeaeno i?io?eaeoe/ii? aoaeoeaiino? (?IA) nee?ai?o ei?enooaaeenue
aeni?an-iaoiaeii aecia/aiiy na?aaeiuei? aoaeoeaii? aeice oa ?? iiieeee
(A.A. I?ici?ianeee e niaao., 1978). Aeey ia/eneaiiy aaee/eie ?IA
aeei?enoiaoaaee caaaeueiii?eeiyoee a aioeaeioieia?? iaoiaee/iee i?eeii:

?IA = EAe50 io?ooe i?e i?io?eaeoe/iiio aaaaeaii? i?aia?aoo (aeine?ae)
EAe50 io?ooe aac aaaaeaiiy i?aia?aoo (eiio?ieue).

Aeno?aiieyoe?th aeic AeIIE ? nee?ai?a, io?eiaieo a aenia?eiaio?, ia
ethaeeio i?iaiaeeee ca aeiiiiiaith iaoiaeo i?iaiicoaaiiy ?ciaoaeoeaii?
oa oiene/ii? aeic ?a/iaei, yeee cai?iiiioaaee TH.?. ?eaieiae?a oa ?.N.
?eaieiae?a (1979), ca eiinoaioaie a?ieia?/ii? aeoeaiino? (Ea).

?ioaineai?noue i?io?eaiiy a?eueii?aaeeeaeueieo i?ioean?a o e?ia? oa
aiiiaaiaoao ia/?iee ioe?ithaaee a?ioai?ethi?ianoeaioiei iaoiaeii ca
aeiiiiiaith ethi?iiiao?a EMILITE-1105 aano?i-i?iaoeueei-?in?enueeiai
ae?iaieoeoaa o??ie “A?i-O?i-Iae”. Niaeo?aeueiee ae?aiacii
oai?ethi?iiiao?a neeaaea? 350-950 ii, a ae?aiacii aei??thaaiue — 103 —
1010 oioii/ n.

Aeey ?iaeoeoe?? a?eueii?aaeeeaeueieo ?aaeoe?e aeei?enoiaoaaee 3% ?ic/ei
ia?aeeno aiaeith (A.I. Neaei?ee e niaao., 1989) ca oaeineiiaeaiith
ni?a?ia?oieeaie eaoaae?e oa?iaeieia?? EAeIO iaoiaeeeith (A.A. Eunaiei e
niaao., 1992). I?e aiae?c? io?eiaieo oai?ethi?iia?ai ioe?ithaaee
aiie?ooaeo ia?oiai (oaeaeeiai) niaeaoo na?o?iiy (I1).

Noai IIE ioe?ithaaee ca ai?noii a aiiiaaiaoao ia/?iee ??aiy ia?aeiieo
i?iaeoeo?a — ae??iiaeo eii’thaao?a (AeE), i?ii?aeieo — a?ae?iia?aeen?a
(AI), a oaeiae e?ioeaaeo — i?iaeoeo?a, ui ?aaaothoue c
2-o?iaa?a?oo?iaith eeneioith (OAE-aeoeai? i?iaeoeoe) a aeeiai?oe?: /a?ac
1, 3 oa 6 aiaeei a?ae iiiaioo aaaaeaiiy io?ooe a i?aai?ci.

Aecia/aiiy AeE (iiieue/a ne?i? oeaieie) i?iaiaeeee ca iaoiaeii
(E.Ae. Noaeueiay, 1977), yeee caniiaaiee ia ?aeaioeo?eaoe?? ni?yaeaieo
iiaea?eieo ca’yce?a c iaeneioiii aae?aiiy a OO-iaeano? i?e aeiaaeei?
oaee? 233 ii. ??aaiue AI (oiiai? iaeeieoe?, ui a?aeiia?aeathoue
cia/aiiyi NOo100) aecia/aee ca iaoiaeii (E.A. ?iiaiia, E.Ae. Noaeueiay,
1978), ui aaco?oueny ia ?a?no?aoe?? iioe/ii? aonoeie i?e 480 ii c
aeei?enoaiiyi o?ioe?iiaoo aiii?th. Ai?no OAE-aeoeaieo i?iaeoeo?a
(iiieue/a ne?i? oeaieie) aecia/aee ca ?aaeoe??th c 2-OAE c iaeneioiii
aae?aiiy iioe/iiai aei?ii?ithaaiiy i?e aeiaaeei? oaee? 540 ii (E.Ae.
Noaeueiay, A.A. Aa?oeaeee, 1977).

I?e aea/aii? ooieoe?iioaaiiy iniiaieo eiiiiiaio?a aioeieneaeaioii?
nenoaie caoenoo i?aai?cio (a aeeiai?oe?: /a?ac 1, 3 oa 6 aiaeei a?ae
iiiaioo iaaeoiaeaeaiiy AeIIE aei i?aai?cio) aecia/aee aeoeai?noue
iaeiiai c eeth/iaeo oa?iaio?a — eaoaeace (ieao/e) ca iaoiaeii, yeee
cai?iiiioaaee I.I. Ei?iethe oa ni?aaao. (1988). I?i caaacia/aii?noue
i?aai?cio aiaeiaaiieie aioeieneaeaioaie noaeeee ca noaiii ia?aeenii?
?acenoaioiino? a?eo?ioeeo?a (a?aenioie aaiie?co), yeo ioe?ithaaee
a?aeiia?aeii ?nioth/iai iaoiaea ( I.A. A?oeiiaa, 1988).

Aecia/aiiy ai?noo noeueoa?ae??eueieo a?oi a oe?euei?e e?ia? (iiieue/e)
i?iaiaeeee ca iaoiaeii I. A1lman (1959).

Ioe?ieo IAAeOI-caeaaeii? iiiiieneaaiacii? oa?iaioaoeaii? nenoaie
ia/?iee o eaai?aoi?ieo oaa?ei i?e ?ioieneeaoe?? AeIIE ? aeei?enoaii?
a?ioeaaiii?aea nee?ai?a cae?enithaaee ca aeiiiiiaith aecia/aiiy nooiaith
aeaiaoeethaaiiy ai?aeii??eio, i?i yeee noaeeee ii aeaaaeaiith iniiaieo
eiai iaoaaie?o?a (4-ai?iiaioei??eio oa N-aoeaoee-4-ai?iiaioei??eio
(iea/ie) c na/ath ca iaoiaeii, yeee cai?iiiioaaee I.A. Eaiiaiei oa O.A.
Iiiia (1981). I?eioeei aeaiiai iaoiaeo caniiaaiee ia ooai?aii? a
i?ioean? aca?iiae?? 4-ai?iiaioei??eio c oaiieii niieoee oeio ?iaeioaiieo
/a?aiiiai eieuei?o a eoaeiiio na?aaeiaeu? a i?enooiino? oa?eoe?aieaeo
eae?th.

Ine?eueee iaea?eueo ae?aaeai? iiaeeo?eaoe?? oeeoio?iio ?-450 i?e
io?o?ii? aeei?o?ioaiieueieie niieoeaie aeyaeai? o ia?o? aiaeeie ?icaeoeo
aeaiiai iaoieia?/iiai i?ioeano (A.Ae. Eoeueyi/oe, 1988 ?.), aene?aoe?th
iaoaaie?o?a ai?aeii??eio c na/ath aecia/aee /a?ac 6 oa 24 aiaeeie i?ney
io?o?iiy AeIIE. I?e aecia/aii? ai?noo iaoaaie?o?a ai?aeii??eio a na/?
uo??a ca oiia aenia?eiaioo aeei?enoiaoaaee noaiaea?oi? iai?ii? ee?oeie.
I?e oeueiio i?iaiaeeee aiaeia iaaaioaaeaiiy c ?ic?aooieo 2% aiaee a?ae
iane o?ea oaa?eie.

E??i oiai, noai i?ioean?a a?io?ainoi?iaoe?? AeIIE ia oe? canoinoaaiiy
nee?ai?o ioe?ithaaee ca o?eaae?noth iaaeeeaiaioiciiai nio o oaa?ei ca
oiia aioo??oiuei/a?aaeiiiai aaaaeaiiy 1% aiaeiiai ?ic/eio aaenaiaeo a
aeic? 70 ia/ea (A.Ae. ?icaiiaa, 1979).

O na??? oieneeie?iaoe/ieo aeine?aeaeaiue eiioeaio?aoe?th AeIIE a na/? oa
e?ia? aecia/aee ca aeiiiiiaith niaeo?ioioiiao?e/iiai iaoiaeo,
caniiaaiiiai ia ?aeaioeo?eaoe?? ianoeoeeaeo, yeee aeno?aaothoue c
a?inoano?ao?a iaoeeaoeeeaoiiii. Iioa?aiaaio niieoeo niaeo?ioioiiao?oaaee
ia NO-46 i?e aeiaaeei? oaee? 440 ii. Ai?no AeIIE ae?aoiaoaaee ii
eae?a?oaaeueiiio a?ao?eo. *ooeea?noue iaoiaeo — 0,5 iea ?a/iaeie o i?ia?
e?ia?, 1 iea — o i?ia? na/? (A.I. Ao?eaoeeay e niaao., 1978).

C iaoith iaeneiaeueii ei?aeoii? ioe?iee aieeao nee?ai?o ia ia?aiao?e
oieneeie?iaoeee AeIIE o a?ina?aaeiaeuao i?aai?cio aecia/aee ianooii?
iieacieee: iaeneiaeueio eiioeaio?aoe?th o e?ia? (Cmax,, ia/ie), /an
aeinyaiaiiy iaeneiaeueii? eiioeaio?aoe?? o e?ia? (tmax, aiae), ii/aoeiao
eiioeaio?aoe?th, ui caea?oueny o e?ia? (N0, ia/ie), eiinoaioo
ae?i?iaoe?? (Eae, aiae-1), ia??iae iai?aaeaaaeaiiy (t1/2, aiae), ianya
?iciiae?eo, ui caea?oueny (Vd, ie), caaaeueiee (Clt, ie/aiae),
?aiaeueiee (ClR, ie/aiae) oa aeno?a?aiaeueiee (ClER, ie/aiae) ee??aine,
ieiuo i?ae oa?iaeioa?aiaaoe/iith e?eaith (AUC, iea”aiae”ie-1).

Ia?ae?/ai? oieneeie?iaoe/i? iieacieee aecia/aee ca aeiiiiiaith
iaoiaee/ieo i?eeii?a, iienaieo o e?oa?aoo?? (A.I. Nieiaueaa e niaao.,
1980; E.A. Oieiaeia, A.I. sseiaeaa, 1985). Oae, aaee/eio Cmax
aecia/aee c ai?ieneiiaaiiai a?ao?eo ooieoe?? caeaaeiino? eiioeaio?aoe??
ianoeoeeaea o a?ina?aaeiaeuao a?ae /ano ye iaeneiaeueia cia/aiiy oe???
ooieoe??. Ia?aiao? tmax — oea /an, ui a?aeiia?aea? iaeneiaeuei?e
eiioeaio?aoe?? i?aia?aoo, yeee aea/a?oueny o a?inoano?ao?. Aeey
iaea?aeaiiy iaeneiaeueii? a??ia?aeiino? iieaciee Eae aecia/aee aeaiia
iaoiaeaie, a naia: ca e?iaoe/iith e?eaith o eii?aeeiaoao “lg C-t”, a
oaeiae ca oi?ioeith: Eae=2,303 o tgg.

Eeth/iaee oieneeie?iaoe/iee ia?aiao? — t1/2 oaeiae ioe?ithaaee ca
aeiiiiiaith e?eai? o eii?aeeiaoao “lg C-t” oa ca oi?ioeith: t1/2=ln 2/E
ae

Aaee/eio lgN0 aecia/aee ye oi/eo ia?aoeio c a?nnth i?aeeiao lgN
i?iaeiaaeaiiy i?yii? iiiiaeniiiaioe?eiiai cieaeaiiy eiioeaio?aoe?? AeIIE
o eii?aeeiaoao “lg C-t”. Iieaciee, ui oa?aeoa?eco? Vd ciaoiaeeee ?c
caeaaeiino? Vd=D/N0, aea D — aaaaeaia a i?aai?ci iaeii?aciaa aeica
io?ooe, yea a?aeiia?aea? na?aaeiueinia?oaeuei?e.

Eiiieaen oieneeie?iaoe/ieo eiinoaio, ui na?ae/aoue i?i oaeaee?noue
“i/euaiiy” i?aai?cio a?ae oiene/iiai aaaioo, cie?aia aaee/eie ClT oa
ClR, ?ic?aoiaoaaee ca oi?ioeaie: ClT =Vd x Eae oa ClR=Vd o Eae,
a?aeiia?aeii, a ClER — ye ??cieoeth i?ae caaaeueiei oa ?aiaeueiei
ee??ainaie.

An? aeei?enoai? i?e aeeiiaii? ?iaioe iaeeieoe? aei??thaaiue ? ia?aiao?e
iaaaaeaii o a?aeiia?aeiino? c i?aeia?iaeiith nenoaiith iaeeieoeue (A.
Eeii?ao, 1980). Io?eiai? oeeo?ia? ?acoeueoaoe ia?iaeyee noaoenoe/ii ca
aeiiiiiaith e?eoa??th No’thaeaioa (TH.E. Eaaiia, Ae.I. Iioi?aethe,
1990), a oaeiae iaia?aiao?e/iiai e?eoa??th O?oa?a (A.A. Aoaea?, 1978).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

A ?acoeueoao? i?iaaaeaieo oieneeiiao?e/ieo aeine?aeaeaiue anoaiiaeaii,
ui nooi?iue oiene/iino? AeIIE caeaaeeoue a?ae naciiiino? eiai aieeao ia
i?aai?ci oaa?ei ? noaiiaeoue 39,1 – 48,7 ia/ea. Aeno?aiieyoe?y aeaieo,
io?eiaieo a aenia?eiaio?, aeicaieeea aeyaeoe ?ic?aooieiao aaee/eio EAe50
AeIIE aeey ethaeeie, yea neeaaea? 6,3 ia/ea.

A?aoiaoth/e aaee/eio EAe50 ? oeyo iaaeoiaeaeaiiy io?ooe aei i?aai?cio,
iiaeia eiinoaooaaoe (a?aeiia?aeii aei AINO 12.1.007-76), ui AeIIE
a?aeiineoueny aei a?oie aenieiiaaacia/ieo (I eean iaaaciaee) niieoe aeey
ethaeeie.

A ?acoeueoao? ne?ei?iaiaeo aeine?aeaeaiue anoaiiaeaii, ui c on?o
a?ioeaaiii?aeieo i?aia?ao?a (oeaeoi?i, oeai?i, eiiaaoeaa?i, nee?a?i?i,
eaa?oeaoei oa nee?ai?), ye? aea/aeenue, iaea?eueoo i?io?eaeoe/io
aoaeoeai?noue (+83,4%) i?iyaea nee?ai?, i?ioaeoi?ia aeoeai?noue yeiai
?aae?coaaeany aenieei a?aenioeii aeaeeaaiiy aenia?eiaioaeueieo oaa?ei,
aeaaii?e?iiei aieeaii ia ia?aa?a ee?i?/ii? ea?oeie ?ioieneeaoe?? oa
no?iee caaeaae? uo??a.

Aeine?aeaeaiiyie ii ?ic?iaoe? iioeiaeueiiai aeiciaiai ?aaeeio
i?io?eaeoe/iiai canoinoaaiiy nee?ai?a ia iiaeae? aino?i? (EAe50)
ia?i?aeueii? ?ioieneeaoe?? AeIIE anoaiiaeaii, ui i?aia?ao aeyaey?
iaea?eueo ae?aaeaiee aoaeo i?e eiai aaaaeaii? a aeic? 165 ia/ea ca 75
oaeeei aei ii/aoeo iaaeoiaeaeaiiy ianoeoeeaeo aei i?aai?cio (oaae.1).

Oaaeeoey 1

I?IO?EAEOE*IA AOAEOEAI?NOUe NEE?AI?O I?E IA?I?AEUeIIIO AAAAeAII? O
??CIEO AeICIAEO ?AAEEIAO CA OIIA AINO?I? ?IOIENEEAOe?? UO??A AeIIE
(n=12)

Aeica*anAeaeeaaiiy, %nee?ai?o,

ia/eaaaaaeaiiy nee?ai?o, oaeeEiio?ieue I?io?eae-oeeaI?io?eae-oe/iee
aoaeo, %PX

30

30

75

12033,3

33,3

33,316,6

0

0-16,6

-33,3

-33,3>0, 025

>0, 025

>0, 025

165

30

75

12016,6

16,6

16,650,0

100,0

66,6+33,3

+83,4

+50,0>0, 025

<0, 025 <0, 025 300 30 75 12016,6 16,6 16,633,3 66,6 50,0+16,6 +50,0 +33,3>0, 025

<0, 025 >0, 025

I?ei?oea:

?X — ?ic?aoiaaii ca aeiiiiiaith oi/iiai iaoiaeo O?oa?a
aeey /ioe?ueioiieueii? oaaeeoe?.

O oiae? aenia?eiaioo aoei anoaiiaeaii aaee/eio ?IA nee?ai?o ca oiia
aino?i? ?ioieneeaoe?? AeIIE, yea neeaea 1,39.

Oaeiae iaei nain, c i?aeoe/ii? oi/ee ci?o, aecia/eoe ?ciaoaeoeaio aeico
nee?ai?o aeey ethaeeie. Aeoiaey/e c aeaieo, io?eiaieo a aenia?eiaio? ia
uo?ao, anoaiiaeaii, ui iaea?eueo aoaeoeaia aeica i?aia?aoo aeey uo??a
(165 ia/ea) a?aeiia?aea? aeic? 25,9 ia/ea aeey ethaeeie.

Ianooiiei aoaiii ?iaioe aoei aea/aiiy aieeao nee?ai?o ia oieneeie?iaoeeo
AeIIE o a?ina?aaeiaeuao i?aai?cio. C oe??th iaoith aea/aee ?yae
e?iaoe/ieo ia?aiao??a, ui oa?aeoa?ecothoue aene?aoi?ii-ae?i?iaoe?ei?
i?ioeane a i?aai?ci? io?o?ieo uo??a: Cmax; tmax; Vd; C0; T1|2; Kee; ClT;
ClR; ClER. ?acoeueoaoe, io?eiai? a aenia?eiaio?, ia?aeiieeai aeacothoue
ia oa, ui i?e ia?i?aeueiiio iaaeoiaeaeaii?, AeIIE a?ae??ciy?oueny
aaeeeith oaeaee?noth aniieooaaiiy c aeinyaiaiiyi iaaeoi aeniei?
eiioeaio?aoe?? ianoeoeeaeo o e?ia? oa aeinoaoiuei o?eaaeei /anii
oee?eoeyoe?? o nenoaiiiio e?iaiia?ao o oeeo eiioeaio?aoe?yo, a oaeiae
aenieei nooiaiai a?iaeinooiiino? (oaae. 2).

Oaaeeoey 2

IA?AIAO?E OIENEEIE?IAOEEE AeIIE O NE?IAAOOe? E?IA? OA NA*? UO??A CA OIIA
AINO?IAI IA?I?AEUeIIAI IO?O?IIss AeIIE OA CANOINOAAII? NEE?AI?O (n=8)

Oieneei -Ne?iaaoea e?ia?Na/ae?iaoe/i? ia?aiao?e?ici??i?noueAeIIE

Nee?ai? +

AeIIEAeIIENee?ai? +

AeIIECmaxia/ie0,0710,0480,0420,195tmaxaiae112424Vdie644,301851,85——C0ia/
ie0,0780,0270,1550,479t1/2aiae7,373,6328,8814,43Keeaiae-10,0940,1910,055
0,111ClTie/aiae60,56353,70——ClRie/aiae——48,76154,17ClERie/aiae11,80199,5
3——AUNiea”aiae”ie-1829,78141,362818,18431,53

Aiae?c oieneeie?iaoe/ieo ia?aiao??a, ye? oa?aeoa?ecothoue i?ioeane
aeaaaeaiiy c i?aai?cio, aeicaiey? c?iaeoe aeniiaie i?i oa, ui iaea?eueoa
/anoeia io?ooe aeaiaeeoueny c i?aai?cio o iaci?iiiio aeaeyae? /a?ac
ie?ee. Ioe?ithth/e ia?aiao?e oieneeie?iaoeee AeIIE a ne?iaaooe? e?ia?,
o?aaa caa?iooe oaaao ia ??cea ciaioaiiy (iaeaea o 2 ?ace) aaee/eie t1/2
? ca?eueoaiiy o 2,9 ?ace ianyao ?iciiae?eo, a oaeiae cieeiaiiy io?ooe c
e?ia? ia 48 aiaeei ?ai?oa o a?oi? oaa?ei, yeei c i?io?eaeoe/iith iaoith
aaiaeeee nee?ai?, o ii??aiyii? c eiio?ieueiith a?oiith (aac aaaaeaiiy
nee?ai?o). I?i oea ae na?ae/eoue ? ia/eneaia a ne?iaaooe? e?ia?
aeine?aeieo oaa?ei (i?io?eaeoeea nee?ai?ii) aaee/eia AUC, yea iaeaea a 6
?ac?a iaioa ca oaeee iieaciee a a?oi? eiio?ieth. Caoenia ae?y nee?ai?o
i?e ?ioieneeaoe?? AeIIE aeyaey?oueny oaeiae o ni?iiiaeiino? i?aia?aoo
ca?eueooaaoe ia 50,8% oaeaee?noue cieeiaiiy io?ooe c e?ia?. Oea
i?iyaey?oueny a ca?eueoaii? aaee/ei caaaeueiiai oa aeno?aie?eiaiai
ee??ain?a (aeea.oaae.2)

Aea/aiiy aeeiai?ee ai?noo AeIIE o na/? aeyaeei i?eioeeiia? a?aei?iiino?
o oaeaeeino? aeaaaeaiiy enaiia?ioeea c i?aai?cio (o aeine?aei?e a?oi? ia
36 aiae ?ai?oa ca eiio?ieue). Ia??iae iai?aaeaaaeaiiy i?e aaaaeaii?
nee?ai?o, ye ? o e?ia?, o 2 ?ace a?eueoee, i?ae o eiio?ieuei?e a?oi?
uo??a.

Aiae?coth/e e?iaoeeo AeIIE o na/?, ne?ae aeacaoe ia oa, ui oaeaee?noue
“i/euaiiy” i?aai?cio a?ae oiene/iiai aaaioo ca oiia aaaaeaiiy
a?ioeaaiii?aeo ia 50,5% a?eueoa, i?ae o eiio?ieuei?e a?oi?.

I?aeaeaath/e i?aenoiie ?acoeueoao?a aeine?aeaeaiue oieneeie?iaoeee AeIIE
ca oiia aeaiiai aenia?eiaioo, o?aaa a?aecia/eoe, ui iaeiei c oeyo?a
aeaoieneeaoe?? i?aai?cio ca aeiiiiiaith iiia?aaeiuei aaaaeaiiai nee?ai?o
? ni?iiiaei?noue i?aia?aoo ci?ithaaoe e?iaoeeo AeIIE ca oiia aino?iai
io?o?iiy oeyoii cieaeaiiy eiioeaio?aoe?? ianoeoeeaeo a e?ia? oa
ca?eueoaiiy ?? o na/?, a oaeiae i?enei?aiiy i?ioeano aeaaaeaiiy oeueiai
enaiia?ioeea c i?aai?cio.

Ine?eueee aea/aiiy a?io?ainoi?iaoe?? oiene/ieo aaaio?a ??cii? o?i?/ii?
aoaeiae oa aieea ia oeae i?ioean iioaioe?eieo i?ioaeoi?ieo cania?a ?
iaeiei c oeaio?aeueieo caaeaiue no/anii? oa?iaeieia???, oieneeieia?? oa
aioeaeioieia??, cie?aia, oi aoei aeioe?eueiei aea/eoe ni?iiiaei?noue
nee?ai?o iiaeeo?eoaaoe a?io?ainoi?iaoe?th AeIIE ca oiia aino?i?
?ioieneeaoe??.

C oe??th iaoith aoei i?iaaaeaii ie?aio na??th aenia?eiaioaeueieo
aeine?aeaeaiue ii aecia/aiith ai?noo aene?aoiaaieo c na/ath iaoaaie?o?a
ai?aeii??eio: 4-ai?iiaioei??eio oa N-aoeaoee-4-ai?iiaioei??eio i?ney
iaaaioaaeaiiy aeaiei ianoa?i?aeiei aiaeueaaoeeii.

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue aoei aeyaeaii, ui i?ae aieeaii
AeIIE a?aeaoaa?oueny ??cea i?eai?/aiiy iaoaaie?cio ai?aeii??eio ye /a?ac
6, oae ? /a?ac 24 aiaeeie, ui i?iyaey?oueny a cieaeaii? aene?aoe??
4-ai?iiaioei??eio ia 38,5% oa 29,7%, a?aeiia?aeii. A aene?aoe?? ?ioiai
iaoaaie?oo ai?aeii??eio — N-aoeaoee-4-ai?iiaioei??eio ca oiia
AeIIE-?ioieneeaoe??, niinoa??aa?oueny aiaeia?/ia ea?oeia.

Aenia?eiaioaeueii aeiaaaeaii, ui i?e canoinoaaii? a?ioeaaiii?aeo
aeaaaeaiiy c na/ath 4-ai?iiaioei??eio o io?o?ieo oaa?ei a cia/i?e i???
iineeth?oueny o ii??aiyii? c eiio?ieueiith a?oiith ia 362,9% ? 272,8%
/a?ac 6 oa 24 aiaeeie, a?aeiia?aeii. A?aoiaoth/e iano?eueee ae?aaeaia
i?aeneeaiiy aene?aoe?? ai?iiiio?aeiiai iaoaaie?oo ai?aeii??eio,
caea?oueny iiaeeeaei noaa?aeaeoaaoe i?i ni?iiiaei?noue a?ioeaaiii?aeo
aeyaeyoe ?iaeoeoth/ee aoaeo ii a?aeiioaiith aei oa?iaio?a
iiiiieneaaiacii? nenoaie ia/?iee. Noiaea ea?oeia niinoa??aa?oueny ? i?e
aiae?c? aeaieo, io?eiaieo i?e aecia/aii? nooiaith aene?aoe?? c na/ath
aoeaoeeueiaaiiai iio?aeiiai ai?aeii??eio ca oiia i?io?eaeoe/iiai
aaaaeaiiy a?ioeaaiii?aeo i?e io?o?ii? AeIIE.

Oaeei /eiii, ca oiia AeIIE-?ioieneeaoe?? niinoa??aa?oueny ae?aaeaia
i?eai?/aiiy ?aaeoe?e I oace a?io?ainoi?iaoe??: ai?ioaaiiy ?
aoeaoeethaaiiy c aeii?ioaaiiyi inoaiiuei?, ia iniia? /iai iiaeia c?iaeoe
aeniiaie i?i ii?ooaiiy ooieoe?iioaaiiy i?e?iniiaeueii? eaiee
aeaoieneeoth/i? nenoaie i?aai?cio.

Ianooiiei aoaiii ?iaioe aoei aea/aiiy ciaoeiaeaeoth/i? ooieoe?? ia/?iee
o uo??a, yeei aaiaeeee nee?ai? c i?io?eaeoe/iith iaoith ca oiia aino?iai
(EAe50) io?o?iiy AeIIE, ca aeiiiiiaith oaeiai ?ioaa?aeueiiai iieacieea
ooieoe?iioaaiiy iiiiieneaaiacii? nenoaie ye o?eaae?noue aaenaiaeiaiai
nio.

Anoaiiaeaii, ui i?e ?ioieneeaoe?? AeIIE a cia/i?e i??? ca?eueoo?oueny
o?eaae?noue aaenaiaeiaiai nio o io?o?ieo uo??a. Aaea /a?ac 1 aiaeeio
i?ney aaaaeaiiy ianoeoeeaeo aei i?aai?cio oaa?ei aeaiee iieaciee ia
138,0% a?eueoa o ii??aiyii? c aaee/eiith,yea aecia/a?oueny a a?oi?
?ioaeoieo uo??a. A ianooii? no?iee niinoa?aaeaiiy (3 oa 6 aiaeei)
aeyaey?oueny eeoa aeayea oaiaeaioe?y aei ciaioaiiy o?eaaeino? nio,
aeeeeeaiiai aa?a?oo?aoii, ia oe? aino?i? ?ioieneeaoe??.

Aiae?c aeaieo, io?eiaieo i?e aecia/aii? o?eaaeino? aaenaiaeiaiai nio o
oaa?ei, yeei aaiaeeee c i?io?eaeoe/iith iaoith nee?ai? ca oiia io?o?iiy
AeIIE, aeaco? ia oa, ui a?ioeaaiii?ae a??ia?aeii (?<0,001) ciaioo? aeai?eioth/ee aoaeo aa?a?oo?aoo o an? no?iee aea/aiiy. Ioe?ithth/e aieea nee?ai?o ia noai nenoaie aeaoieneeaoe?? i?aai?cio i?e AeIIE-?ioieneeaoe??, ia iiaeia ia?eoe oaaaith ? oie oaeo, ui i?ney 6 aiaeei a?ae ii/aoeo io?o?iiy o?eaae?noue aaenaiaeiaiai nio o oaa?ei, yeei aaiaeeee nee?ai?, aoea iaioa, i?ae o ?ioaeoieo uo??a. I?e/eiith oeueiai iiaea aooe ni?iiiaei?noue nee?ai?o ?aae?coaaoe aeanoeaino? ?iaeoeoi?a oa?iaio?a iiiiieneaaiacii? nenoaie ia/?iee. Aeoiaey/e c oeueiai, oa aeeeaaeaieo aeua ?acoeueoao?a aeine?aeaeaiiy, ? oe?eeii eia?/iei noaa?aeaeaiiy i?i oa, ui a iniia? iaoai?cio aeaoieneeoth/iai aoaeoo nee?ai?o eaaeeoue eiai ni?iiiaei?noue ?iaeoeoaaoe oa?iaioe iiiiieneaaiacii? nenoaie ia/?iee, na?aae yeeo iniaeeai o?aaa aeae?eeoe oeeoio?ii ?-450. Ianooiio na??th aeine?aeaeaiue aoei i?enay/aii aea/aiith aieeao nee?ai?o ia e?iaoeeo a?eueii?aaeeeaeueieo ?aaeoe?e, i?ioeane e?i?aeia?aieeneaiiy oa noai aioeieneaeaioii? nenoaie i?aai?cio a oiiaao ?ioieneeaoe?? AeIIE. Anoaiiaeaii, ui aino?a ?ioieneeaoe?y AeIIE noi?iaiaeaeo?oueny aeinoaoiuei ?noioiith ?i?oe?aoe??th a?eueii?aaeeeaeueieo i?ioean?a o ne?iaaooe? e?ia? oaa?ei (a 3 ?ace o ii??aiyii? c ?ioaeoieie oaa?eiaie) a on? no?iee aeine?aeaeaiiy (aeea. oaae.3). O?aaa a?aei?oeoe, ui ca oiia aino?i? ?ioieneeaoe?? AeIIE, iniaeeai /a?ac 3 oa 6 aiaeei i?ney ii/aoeo io?o?iiy, a aeine?aei?e a?oi? (i?io?eaeoeea nee?ai?ii) a?aeaoaa?oueny cieaeaiiy iaaeneaaeiai na?o?iiy ne?iaaoee e?ia? iaeaea o 2 ?ace a ii??aiyii? c eii?ieueieie oaa?eiaie (aac aaaaeaiiy i?aia?aoo). Aea/aiiy aeeiai?ee oaeaeeino? ?aaeeeaeiooai?aiiy o ia/?ioe? iieacaei, ui o oeueiio i?aai? Oaaeeoey 3 AIEEA NEE?AI?O IA AeEIAI?EO CI?IE ?IOAINEAIINO? IAAeNEAAEIAI NA?O?IIss (NE?IAAOEA E?IA? OA AIIIAAIAO IA*?IEE) OA AI?NO I?IAeOEO?A E?I?AeIA?AIEENEAIIss (IA*?IEA) I?E AINO??E ?IOIENEEAOe?? (EAe50) AeIIE (n=6-8) OiiaeNoaoenoe/-iee?ioaeoi? oaa?eieNo?iee aeine?aeaeaiiy, aiaeeieaeine?aeoiieaciee136AIIE?OOAeA OAEAeEIAI NIAEAOO AOE (NE?IAAOEA , OIOII/NAE) AeIIE M ±m 0,63 0,11 1,89* 0,37 1,94* 0,19 2,01* 0,30 Nee?ai? + AeIIEM ±m 0,63 0,11 1,30* 0,12 1,08*/** 0,13 1,02*/** 0,09 AIIE?OOAeA OAEAeEIAI NIAEAOO AOE (IA*?IEA, OIOII/NAE) AeIIE M ±m 0,38 0,03 1,75* 0,22 1,90* 0,26 1,63* 0,20 Nee?ai? + AeIIE M ±m 0,38 0,03 1,00*/** 0,18 1,20*/** 0,20 1,23* 0,24 Ae??IIA? EII’THAAOE (IIIEUe/A NE?I? OEAIEIE) AeIIE M ±m 0,181 0,016 0,446* 0,040 0,303* 0,010 0,425* 0,040 Nee?ai? + AeIIEM ±m 0,181 0,016 0,176** 0,014 0,135*/** 0,006 0,166** 0,013 A?Ae?IIA?AEENE E?I?Ae?A (OIIAI? IAeEIEOe?) AeIIEM ±m 3,3 0,28,0* 0,6 2,8 0,2 1,8* 0,2 Nee?ai? + AeIIE M ±m 3,3 0,2 4,3*/** 0,2 1,6*/** 0,1 1,3*/** 0,1 OAE-AEOEAI? I?IAeOEOE (IIIEUe/A NE?I? OEAIEIE) AeIIE M ±m 115,4 10,6174,7* 6,4 193,9* 11,7 237,2* 11,3 Nee?ai? + AeIIE M ±m 115,4 10,6 40,6*/** 3,9 58,7*/** 3,0 79,0*/** 7,3 I?ei?oea: *- a?aei?iiino? a??ia?aei? o ii??aiyii? c a?oiith ?ioaeoieo oaa?ei (P<0,05); **- a?aei?iiino? a??ia?aei? o ii??aiyii? c eiio?ieai, oiaoi aac canoinoaaiiy i?aia?aoo (P<0,05). i?ae aieeaii AeIIE a?eueii?aaeeeaeuei? ?aaeoe?? i?io?eathoue cia/ii iaio ?ioaineai?oa, i?ae o e?ia?. Iaiao?aeii a?aei?oeoe, ui ?ioaineai?noue iaaeneaaeiai na?o?iiy o aiiiaaiao? ia/?iee io?o?ieo uo??a a e?eueea ?ac?a (iniaeeai /a?ac 3 aiaeeie i?ney aaaeaiiy AeIIE) ia?aaa?oo? iieaciee, ui aecia/a?oueny a a?oi? ?ioaeoieo oaa?ei. I?io?eaeoe/ia ae canoinoaaiiy nee?ai?o ca oiia aino?iai io?o?iiy ianoeoeeaeii i?ecaiaeeoue aei noaoenoe/ii a??ia?aeiiai (?<0,05) cieaeaiiy ??aiy a?eueieo ?aaeeeae?a o ia/?ioe?. Iayai?noue ae?aaeaii? aioe?aaeeeaeueii? aeoeaiino? o nee?ai?o iia'ycaia, iiaeeeai, c? ni?iiiaei?noth i?aia?aoo iiia?aaeaeaoe ?i?oe?aoe?th a?eueii?aaeeeaeueiiai IIE i?e AeIIE-?ioieneeaoe?? oaeiae ? ia a?eueo i?ci?o aoaiao aaaaoinooi/aoiai e?i?aeia?aieeneaiiy. C iaoith c'ynoaaiiy iiaeaeueoeo, iiaeeeaeo iaoai?ci?a caoenii? ae?? a?ioeaaiii?aeo ca aeaieo oiia aenia?eiaioo aoei i?iaaaeaii na??th aeine?aeaeaiue ii aea/aiith aeeiai?ee ai?noo AeE, AI oa OAE-aeoeaieo i?iaeoeo?a o ia/?ioe?. Iieacaii, ui aieea AeIIE aaea /a?ac 1 aiaeeio i?ney ii/aoeo ?ioieneeaoe?? i?ecaiaeeoue aei ??ceiai (iaeaea a 2,5 ?ace) i?aeaeuaiiy ??aiy AeE o ii??aiyii? c ?ioaeoieie oaa?eiaie. A oie aea /an a?ioeaaiii?ae iiai?noth oa noaa?eueii iiia?aaeaeo? ooai?aiiy oeeo ia?aeiieo i?iaeoeo?a e?i?aeia?aieeneaiiy o an? no?iee aeine?aeaeaiiy. Iaeneiaeueiee ??aaiue AI o ia/?ioe? i?e io?o?ii? AeIIE ?aeaioeo?eo?oueny o iaea?eueo ?aii? no?iee ?ioieneeaoe?? (1 aiaeeia). ??cea cieaeaiiy ??aiy AI o a?eueo i?ci? no?iee aea/aiiy (3 oa 6 aiaeei) iiaeia iiynieoe iineeaiiei ?oi?i aeo?a/aiiyi ia ooai?aiiy e?ioeaaeo i?iaeoeo?a e?i?aeia?aieeneaiiy (nie?oe, eaoiie, aeueaeaa?aee), ye? ?aaaothoue c 2-OAE. Ioe?iea aieeao nee?ai?o ia ai?no AI o ia/?ioe? uo??a i?e aino??e ?ioieneeaoe?? AeIIE iieacaea, ui a?ioeaaiii?ae aeyaey? ae?aaeaio i?ioaeoi?io ae?th o an? no?iee niinoa?aaeaiiy a?aeiinii i?ii?aeieo i?iaeoeo?a IIE (aeea.oaae.3). A ca'yceo c oei, ui AI a?aeiinyoueny aei iaaeoi eaa?eueieo i?iaeoeo?a IIE, ? ?o ai?no o a?ina?aaeiaeuao i?e io?o?ii? AeIIE ia iiaea neoaoaaoe ae?aaiinoe/iei iieacieeii, ui a?aeia?aaea? oyaee?noue ia?aa?ao aeaiiai iaoieia?/iiai i?ioeano, iaei aacnoii?aiee ?ioa?an ioe?ieoe aeeiai?eo ai?noo e?ioeaaeo eiiiiiaio?a i?ioeano IIE ye iaea?eueo noaa?eueieo i?iaeoeo?a ca oiia aenia?eiaioo, ui aea/a?oueny. Ae?enii, ye iieacaee ?acoeueoaoe aeine?aeo, ai?no OAE-aeoeaieo i?iaeoeo?a i?ae aieeaii AeIIE iiiioiiii ca?eueoo?oueny o an? no?iee niinoa?aaeaiiy. I?io?eaeoe/ia ae aaaaeaiiy nee?ai?o i?ecaiaeeoue aei ??ceiai ciaioaiiy aiae?co?ieo i?iaeoeo?a o o? ae no?iee aea/aiiy (aeea. oaae.3). Ine?eueee ia?aeenia ii?ooaiiy no?oeoo?ii-ooieoe?iiaeueiiai noaio a?iiaia?ai i?ecaiaeeoue aei cieaeaiiy e?eueeino? oa aeoeaiino? aiaeiaaiieo aioeieneaeaio?a, caeaoieo ??cei iaiaaeoaaoe aai iiia?aaeaeaoe iioeiaeaeoth/o ae?th i?iaeoeo?a IIE ia ee?oeie i?aai?a oa oeaiei, aoei aeioe?eueiei aea/eoe aeaye? iieacieee noaio aioeieneaeaioii? nenoaie caoenoo i?aai?cio ca oiia ?ioieneeaoe?? ianoeoeeaeii oa i?e canoinoaaii? nee?ai?o. Anoaiiaeaii, ui i?e ?ioieneeaoe?? AeIIE ia? i?noea ae?aaeaia cieaeaiiy ai?noo iaeiiai c eeth/iaeo oa?iaio?a aioeieneaeaioii? nenoaie – eaoaeace o ne?iaaooe? e?ia? uo??a, a oaeiae ??aiy oeieiaeo a?oi o an? no?iee niinoa?aaeaiiy. I?e i?io?eaeoe/iiio canoinoaaii? nee?ai?o ca aeaieo oiia aenia?eiaioo aeoeai?noue eaoaeace (iniaeeai a ia?oo aiaeeio AeIIE-?ioieneeaoe??) ? ??aaiue noeueoa?ae??eueieo a?oi i?aeoe/ii ia a?ae??ciythoueny a?ae ??aiy a a?oi? ?ioaeoieo oaa?ei (?>0,05). Io?eiai?
aeai? na?ae/aoue i?i ni?iiiaei?noue i?aia?aoo iiia?aaeaeaoe ii?ooaiiy
ooieoe?iioaaiiy oa?iaioaoeaii? eaiee oaeaeeiai ?aaaoaaiiy
aioeieneaeaioii? nenoaie i?aai?cio, ??cea i?eai?/aiiy yei?
a?aeaoaa?oueny i?ae aieeaii AeIIE. Aeniea ieenethaaeueii-a?aeiiaia
aeoeai?noue nee?ai?o caaacia/o? “ae?aioth/ee” caoeno noeueoa?ae??eueieo
a?oi, iiia?aaeaeath/e ?o aeieoaaiiy oa ooai?aiiy aeenoeueo?aeieo
ca’yce?a ca oiia aeei?o?ioaiieueii? ?ioieneeaoe??.

Aeine?aeaeaiiy ii aeyaeaiith noaio ia?aeenii? ?acenoaioiino?
a?eo?ioeeo?a ye ?ioaa?aeueiiai iieacieea caaacia/aiiino? i?aai?cio
aiaeiaaiieie aioeieneaeaioaie ca oiia aino?iai aieeao AeIIE iieacaee, ui
i?e aeaiiio iaoieia?/iiio i?ioean? a?aeaoaa?oueny cia/ia (?<0,001) ca?eueoaiiy a?aenioeo aaiie?co a?eo?ioeeo?a o an? no?iee niinoa?aaeaiiy (1, 3 oa 6 aiaeei). I?io?eaeoe/ia canoinoaaiiy nee?ai?o ni?ey? ii?iae?caoe?? ia?aeenii? no?eeino? iaia?ai a?eo?ioeeo?a iaa?oue o ?aii? no?iee ?ioieneeaoe??, aeinyaath/e ??aiy aeo?aeieo aaee/ei /a?ac 3 oa 6 aiaeei (?>0,05).

Ae?aaeaiee iaia?aiinoaa?e?coth/ee aoaeo nee?ai?o, iaaooue, iia’ycaiee c
eiai ni?iiiaei?noth ?iaeoeaoaaoe a?ae?ieneeuei? ?aaeeeaee oa ?ia?aoaaoe
ooai?aiiy noia?ieneae-?aaeeeaeo, a oaeiae i?aeaeuoaaoe aoaeoeai?noue
oa?iaioaoeaii? aioeieneaeaioii? nenoaie caoenoo i?aai?cio.

Oaeei /eiii, ia i?aenoaa? io?eiaieo aenia?eiaioaeueieo aeaieo iiaeeeai
ae?eoe aeniiaeo i?i oai?aoe/ia iaa?oiooaaiiy oa aenia?eiaioaeueia
i?aeoaa?aeaeaiiy caoenieo aeanoeainoae nee?ai?o, yeee canoiniaoaaany c
i?io?eaeoe/iith iaoith i?e aino??e ?ioieneeaoe?? AeIIE. Iaoai?ci ae??
a?ioeaaiii?aeo eaaeeoue a eiai ni?iiiaeiino? aeyaeyoe i?ioaeoi?iee aoaeo
a?aeiinii aeaio oeaio?aeueieo eaiie ?noioieo oeyo?a aeaoieneeaoe??:
iiiiieneaaiacii? oa aioeieneaeaioii? nenoai caoenoo i?aai?cio. Oea
?aae?co?oueny iiaeeo?eaoe??th oieneeieeoaoeee AeIIE aei iineeaiiy
i?ioean?a ae?i?iaoe??, a a e?ioeaaiio i?aenoieo, aenieei aeaeeaaiiyi ?
aeaaii?e?iiei aieeaii ia ia?aa?a ee?i?/ii? ea?oeie ?ioieneeaoe?? oaa?ei,
yeei c i?io?eaeoe/iith iaoith aaiaeeee nee?ai?.

AENIIAEE

1. Ia i?aenoaa? i?iaaaeaieo eiiieaenieo oieneeiiao?e/ieo aeine?aeaeaiue
c aeei?enoaiiyi eiinoaio a?ieia?/ii? aeoeaiino? anoaiiaeaii, ui AeIIE
a?aeiineoueny aei a?oie aenieioiene/ieo (I eean iaaaciaee) niieoe aeey
oaieie?iaieo, a oiio /ene? aeey ethaeeie. Iaea?eueo aeniea oiene/i?noue
AeIIE ?aae?co?oueny a e?oi?e ia??iae ?ieo.

2. ?acoeueoaoe ne?ei?iaiaeo aeine?aeaeaiue aeicaieeee anoaiiaeoe, ui ?c
on?o a?ioeaaiii?aeieo i?aia?ao?a (oeaeoi?i, oeai?i, eiiaaoeaa?i,
nee?a?i?i, eaa?oeaoei oa nee?ai?), ye? aea/aeenue, iaea?eueoo
i?io?eaeoe/io aeoeai?noue ca oiia aino?i? (EAe84)
aeei?o?ii?oie?acieueii? ?ioieneeaoe?? aeyaey? nee?ai?, ui i?iyaey?oueny
noia?aenioeiaei aeaeeaaiiyi uo??a, a oaeiae aeaaii?e?iiei aieeaii ia
ee?i?/io ea?oeio oiene/iiai i?ioeano oa no?iee caaeaae? oaa?ei.

3. ?ic?iaeaii iioeiaeueiee ?aaeei aeicoaaiiy nee?ai?o, ca?aeii yeiio
a?ioeaaiii?ae aeyaey? iaea?eueo aenieo caoenio aeoeai?noue i?e
ia?i?aeueiiio aaaaeaii? a aeic? 165 ia/ea ca 75 oaeeei aei ii/aoeo
iaaeoiaeaeaiiy AeIIE aei oeoieo uo??a. I?e oeueiio aaee/eia ?iaeaeno
i?io?eaeoe/ii? aoaeoeaiino? i?aia?aoo neeaaea? 1,39.

4. Aenia?eiaioaeueii aeiaaaeaii ae?aaeaio ni?iiiaei?noue nee?ai?o
iiaeeo?eoaaoe oieneeie?iaoe/i? ia?aiao?e AeIIE o e?ia? oa na/?:
ii/aoeiao oa iaeneiaeueio eiioeaio?aoe??, ui caeathoueny, eiinoaioo
ae?i?iaoe??, ia??iae iai?aaeaaaeaiiy, ianya ?iciiae?eo, ui caea?oueny,
caaaeueiee, ?aiaeueiee oa aeno?a?aiaeueiee ee??aine ca oiia aino?iai
io?o?iiy AeIIE. Oea i?iyaey?oueny cia/iei cieaeaiiyi eiioeaio?aoe??
ianoeoeeaeo a e?ia? oa ?? ca?eueoaiiyi o na/?, a oaeiae i?enei?aiiyi
i?ioean?a ae?i?iaoe?? oa aene?aoe?? io?ooe c i?aai?cio oaa?ei.

5. Nee?ai?, canoiniaaiee c i?io?eaeoe/iith iaoith ca oiia aino?i?
(EAe50) ?ioieneeaoe?? AeIIE, ei?aao? aeeiai?eo
i?iieneaeaioii-aioeieneaeaioiiai ni?aa?aeiioaiiy a a?ina?aaeiaeuao
i?aai?cio oeyoii ?aae?caoe?? ae?aaeaieo aioe?aaeeeaeueieo aeanoeainoae,
a oaeiae ciaioaiiy i?iaeoeoe?? ae??iiaeo eii’thaao?a, a?ae?iia?aeen?a oa
OAE-aeoeaieo i?iaeoeo?a i?ioeano e?i?aeia?aieeneaiiy.

6. Oa?iaeiei?aeoe?y ii?ooaiue ooieoe?iioaaiiy aioeieneaeaioii? nenoaie
caoenoo i?aai?cio nee?ai?ii ?aae?co?oueny ?noioiei iiia?aaeaeaiiyi
cieaeaiiy aeoeaiino? eaoaeace ? ??aiy noeueoa?ae??eueieo a?oi o e?ia? c
iaeii/aniei i?aeaeuaiiyi ia?aeenii? ?acenoaioiino? a?eo?ioeeo?a oaa?ei,
io?o?ieo AeIIE.

7. Anoaiiaeaii, ui a iniia? caoenii? ae?? nee?ai?o i?e aino?iio
io?o?ii? AeIIE ii?yae c aioeieneaeaioieie aeanoeainoyie a?ioeaaiii?aeo
eaaeeoue eiai ni?iiiaei?noue ?iaeoeoaaoe iiiiieneaaiacio nenoaio
ia/?iee, i?i ui na?ae/eoue cia/ia ca?eueoaiiy a aeeiai?oe?
eiioeaio?aoe?? i?iaeoeo?a ?aaeoe?? I oace a?io?ainoi?iaoe??
ai?aeii??eio: 4-ai?iiaioei??eio oa N-aoeaoee-4-ai?iiaioei??eio a na/?, a
oaeiae ciaioaiiy o?eaaeino? aaenaiaeiaiai nio.

NIENIE I?AOeUe, IAAe?OEIAAIEO CA OAIITH AeENA?OAOe??

1. N?/aiiaa I.A. Ii??aiyeueia oa?iaeioa?aiaaoe/ia aoaeoeai?noue
e?ea?nueeeo cania?a i?e aino??e ?ioieneeaoe?? aeei?o?ii?oie?acieii
//E?ee. -1998. -? 3.- N. 74-76.

2. Ne/aiiaa A.A. Aeeyiea neeeai?a ia i?ioeann ia?aeeniiai ieeneaiey
eeieaeia i?e ino?ie eioieneeaoeee aeeieo?ii?oie?acieii // A?niee i?iaeai
a?ieia?? ? iaaeeoeeie. – 1998.- ? 21.- N. 131-135.

3. N?/aiiaa I.A. Aieea nee?ai?o ia aeaye? iieacieee noaio
aioeieneaeaioii? nenoaie i?aai?cio i?e aino??e ?ioieneeaoe??
aeei?o?ii?oie?acieii// Oe?a?inueeee iaaee/iee aeueiaiao. – 1998. — ? 6.
– N.114-116.

4. Iaoiaee/aneea ?aeiiaiaeaoeee ii eniieueciaaieth iaoiaea
aeioaieethieienoeaioeee a oa?iaeieiaee /A.Ae. Eoeueyi/oe, A.A. Noaoaiia,
E.A. Naa/aieiaa, A.A. Eunaiei, E.A. Naiaiiaa, A.A. Ne/aiiaa,
E.I. Aaeioniaa / Iiae ?aae. i?io. A.Ae. Eoeueyi/oea. — Eoaaine,
1997. –18 n.

5. Ne/aiiaa A.A., Eoeueyi/oe A.Ae. Oai?aoe/aneia iainiiaaiea
oeaeaniia?aciinoe i?eiaiaiey oeaeoieia i?e ino?ii io?aaeaiee
aeeieo?ioaiieueiuie niaaeeiaieyie // Iaoa?eaeu THaeeaeiie
iao/ii-i?aeoe/aneie eiioa?aioeee, iinayuaiiie 100-eaoeth ni aeiy
iniiaaiey 4-e ai?iaeneie aieueieoeu a. Eoaainea. — Eoaaine, 1995. — O 1.
— N. 22.

6. Naiaiiaa ?.I., Naa/aieiaa E.A, N?/aiiaa I.A. A?ioai?ethi?i?noeaioe?y,
ye aaciaee iaoiae aea/aiiy iaoai?cio iioeiaeaeoth/i? ae?? aeno?aiaeueieo
/eiiee?a // VI eiia?an na?oiai? oaaea?aoe?? Oe?. e?ea?nueeeo oiaa?enoa.
-Oac. aeii. — Iaeana, 1996. — N. 235.

7. Ne/aiiaa A.A. Aeeyiea eeieia ia oa/aiea aeeieo?ii?oie?acieueiie
eioieneeaoeee o e?un // THa?eaeiee ca??iee oac.iieiaeeo a/aieo oa
niaoe?ae?no?a /Iiae ?aae. aeaae. A.A. Eiaaoieeiaa. — Eoaaine, 1996. — N.
149.

8. Ne/aiiaa A.A., Ai?oeueei I.A., Eunaiei A.A. Aeeyiea
aeeieo?ii?oie?aciea ia iaeioi?ua iieacaoaee ninoiyiey aioeieneaeaioiie
nenoaiu i?aaiecia//I?aeia?. iaoeiai-i?aeoe/ia eiioa?aioe?y “Aeooaeuei?
i?iaeaie aeia?a??ie ? oieneeieia??”.- Ee?a, 1998.- N. 239-241.

9. Ne/aiiaa A.A., Eunaiei A.A. I?ioeeaeoeea ino?ie eioieneeaoeee n
iiiiuueth aeioeaaiiieaea neeeai?a// Abstracts international Conference:
Environmental and Occupational Health and Safety in Agriculture on the
Bodary of Two Millennia, 1998, Kiev, Ukraine. — Kiev, 1998.- ?. 76-77.

10. Ne/aiiaa A.A. Ne?eieiaiaia enneaaeiaaiea eaea?noaaiiuo n?aaenoa n
iioaioeeaeueiie i?ioaeoi?iie aeoeaiinoueth i?e ino?ie eioieneeaoeee
aeeieo?ii?oie?acieii (AeIIE) // Iao-ee Oe?.iaoeiai? eiioa?aioe??
”Aeooaeuei? i?iaeaie ee?ie/ii? oa?iaeieia??”.- A?iieoey, 1998.- N.
253-254 .

11. Iioei?caoe?y oa?iaeioa?ai?? nee?ai?ii io?o?iiy aeei?o?ii?oie?acieii
/A.Ae. Eoe’yi/oe, A.?. Ioo?ioeaa, I.A. N?/aiiaa, Ae.N. E?aaaoeue,
E.E. Ieinueeee/ ?ioi?iaoe?eiee eeno i?i iiaiaaaaeaiiy a
nenoai? ioi?iie caei?ia’y. — Eoaainuee, 1998. – 3 n.

AIIOAOe??

Ne/aiiaa A.A. Yenia?eiaioaeueiia iainiiaaiea eniieueciaaiey neeeai?a
aeey i?ioeeaeoeee eioieneeaoeee aeeieo?ii?oie?acieii. – ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo
iaoe ii niaoeeaeueiinoe 14.03.05 – oa?iaeieiaey. – Einoeooo oa?iaeieiaee
e oieneeieiaee AII Oe?aeiu, Eeaa, 1999.

Aeenna?oaoeey iinayuaia oai?aoe/aneiio e yenia?eiaioaeueiiio
iainiiaaieth oeaeaniia?aciinoe i?eiaiaiey neeeai?a a ea/anoaa
i?ioeeaeoe/aneiai n?aaenoaa i?e eioieneeaoeee iaeiei ec iaeaieaa
oiene/iuo aeeeeueiuo i?iecaiaeiuo 2,4-aeeieo?ioaiiea –
aeeieo?ii?oie?acieii (AeIIE).

Ia iniiaaiee oieneeiiao?e/aneeo enneaaeiaaiee n eniieueciaaieai eiinoaio
aeieiae/aneie aeoeaiinoe onoaiiaeaii, /oi AeIIE ioiineony e a?oiia
aunieioiene/iuo (I eeann iianiinoe) niaaeeiaiee aeey oaieie?iaiuo, a oii
/enea e /aeiaaea. Iaeaieaa aunieoth oiene/iinoue ianoeoeeae i?iyaeyao a
eaoiee ia?eiae a?aiaie, iaeiaiueooth – ceiie.

I?iaaaeaiu ne?eieiaiaua enneaaeiaaiey ii eco/aieth iaeaieaa yooaeoeaiuo
iioaioeeaeueiuo n?aaenoa eaea?noaaiiie i?ioeeaeoeee, i?eiaiyaiuo a
oneiaeyo ino?ie AeIIE-eioieneeaoeee. Auyaeaii, /oi ec anao eco/aiiuo
aeioeaaiiieaeiuo i?aia?aoia (oeaiei, oeaeoiei, eiiaaoeaaei, neeeaeiei,
eaa?oeaoei e neeeai?) iaeaieueooth i?ioeeaeoe/aneoth aeoeaiinoue
(+83,4%) ieacuaaao neeeai?.

?ac?aaioai iioeiaeueiue aeiciaue ?aaeei i?eiaiaiey neeeai?a a
eco/aaiuo oneiaeyo yenia?eiaioa. Eiaeaen i?ioeeaeoe/aneie yooaeoeaiinoe
ninoaaee 1,39

Onoaiiaeaia au?aaeaiiay niiniaiinoue neeeai?a iiaeeoeoee?iaaoue
oieneeieeiaoe/aneea ia?aiao?u AeIIE a e?iae e ii/a: eaaeothuothny
ia/aeueioth e iaeneiaeueioth eiioeaio?aoeee, eiinoaioo yeeieiaoeee,
ia?eiae iieoauaaaeaiey, eaaeothueeny iauai ?ani?aaeaeaiey, iauee,
ii/a/iue e aiaii/a/iue eee?ainu. Yoi i?iyaeyaony ?aceei nieaeaieai
eiioeaio?aoeee AeIIE a e?iae e oaaee/aieai aa a ii/a, a oaeaea
onei?aieai i?ioeannia yeeieiaoeee e yene?aoeee ianoeoeeaea ec i?aaiecia
aeeaioiuo.

Aeey noaeaeaiey i ninoiyiee aeaoieneoee?othuae nenoaiu i?aaiecia a
oneiaeyo ino?ie eioieneeaoeee AeIIE e i?eiaiaiey neeeai?a eco/aee
ninoiyiea IAAeOI-caaeneiie iiiiieneaaiaciie nenoaiu ia/aie. N yoie
oeaeueth ii?aaeaeyee niaea?aeaiea yene?aoe?oaiuo n ii/ie iaoaaieeoia
aieaeiie?eia: 4-aieiiaioeie?eia e N-aoeaoee-4-aieiiaioeie?eia iinea
iaa?ocee aeaiiui aiaeueaaoeeii. Aeieacaii, /oi iiae aicaeaenoaeai
oiene/aneiai aaaioa i?ienoiaeeo ?aceia oaiaoaiea ?aaeoeee I oacu
aeio?ainoi?iaoeee: aieie?iaaiey e aoeaoeee?iaaiey n i?aiaeaaeaieai
iineaaeiae, eae /a?ac 6 /ania, oae e, iniaaiii, /a?ac 24 /ana.
I?ioeeaeoe/aneia i?eiaiaiea neeeai?a aucuaaao oaaee/aiea (a 4-5 ?ac)
eiioeaio?aoeee yene?aoe?oaiuo n ii/ie iaoaaieeoia aieaeiie?eia ii
n?aaiaieth n a?oiiie eiio?ieueiuo aeeaioiuo (aac aaaaeaiey i?aia?aoa).

A yenia?eiaioa oaeaea onoaiiaeaii, /oi i?e eioieneeaoeee AeIIE a
cia/eoaeueiie noaiaie oaaee/eaaaony aeeeoaeueiinoue aaenaiaeiaiai nia o
io?aaeaiiuo e?un. Aiaeec aeaiiuo, iieo/aiiuo i?e ii?aaeaeaiee
aeeeoaeueiinoe aaenaiaeiaiai nia o aeeaioiuo, eioi?ui aaiaeeee n
i?ioeeaeoe/aneie oeaeueth neeeai? a oneiaeyo io?aaeaiey AeIIE oeacuaaao
ia oi, /oi aeioeaaiiieae nouanoaaiii e aeinoiaa?ii (?<0,001) oiaiueoaao aeai?eie?othuee yooaeo aa?aeoo?aoa ai ana n?iee eco/aiey. Iieo/aiiua ?acoeueoaou naeaeaoaeuenoaotho i oii, /oi aeioeaaiiieae iaeaaeaao au?aaeaiiie i?ioaeoi?iie aeoeaiinoueth a ioiioaiee oa?iaioia iee?iniiaeueiiai ieeneaiey a eco/aaiuo oneiaeyo yenia?eiaioa. Aeaiiia iieiaeaiea iaoei naia yenia?eiaioaeueiia iiaeoaa?aeaeaiea a iiuoao ii eco/aieth i?ioeannia N-aeaiaoeee?iaaiey aieaeiie?eia, ii?aaeaeaieth aeeeoaeueiinoe aaenaiaeiaiai nia o aeeaioiuo, a oaeaea i?e i?e eiiieaeniie ioeaiea aeeyiey neeeai?a ia ?yae oieneeieeiaoe/aneeo ia?aiao?ia yaea a eco/aaiuo oneiaeyo. Eco/aii aeeyiea neeeai?a ia eeiaoeeo naiaiaeii?aaeeeaeueiuo ?aaeoeee, i?ioeannu eeieaeia?aieeneaiey e ninoiyiea aioeieneaeaioiie nenoaiu i?aaiecia a oneiaeyo eioieneeaoeee AeIIE a aeeiaieea: /a?ac 1, 3 e 6 /ania io iiiaioa iinooieaiey yaea a i?aaieci. Onoaiiaeaii, /oi ino?ay eioieneeaoeey AeIIE nii?iaiaeaeaaony aeinoaoi/ii nouanoaaiiie eieoeeaoeeae naiaiaeii?aaeeeaeueiuo i?ioeannia a nuai?ioea e?iae e ia/aie yenia?eiaioaeueiuo aeeaioiuo n iineaaeothuae eioaineoeeaoeeae i?ioeannia eeieaeia?aieeneaiey. Yoi i?iyaeyaony cia/eoaeueiui oaaee/aieai ia?ae/iuo (aeeaiiaua eiiuthaaou), i?iiaaeooi/iuo (aeae?iia?aeene) e eiia/iuo (OAE-aeoeaiuo) i?iaeoeoia ia?aeeniiai ieeneaiey eeieaeia (IIE) a ia/aie e?un ai ana eco/aaiua n?iee. Ia?yaeo n yoei i?ienoiaeeo nouanoaaiiia oaiaoaiea ooieoeeiie?iaaiey aioeieneaeaioiie nenoaiu caueou i?aaiecia. Yoi i?iyaeyaony ?aceei oiaiueoaieai niaea?aeaiey iaeiiai ec eeth/aauo oa?iaioia aeaiiie nenoaiu – eaoaeacu a nuai?ioea e?iae e?un, a oaeaea nieaeaieai o?iaiy oeieiauo a?oii a e?iae ai ana n?iee enneaaeiaaiey (P<0,001). Eco/aiea ninoiyiey ia?aeeniie ?acenoaioiinoe y?eo?ioeeoia, yaeythuaeny eioaa?aeueiui iieacaoaeai iaania/aiiinoe i?aaiecia yiaeiaaiiuie aioeieneaeaioaie, auyaeei aanueia cia/eoaeueiia (?<0,001) oaaee/aiea i?ioeaioa aaiieeca yoeo oi?iaiiuo yeaiaioia e?iae ai ana n?iee iaaethaeaiey. Yenia?eiaioaeueii aeieacaii, /oi a iniiaa i?ioaeoi?iiai iaoaiecia aeaenoaey neeeai?a i?e AeIIE-eioieneeaoeee eaaeeo niiniaiinoue aeioeaaiiieaea eiaeae?iaaoue i?ioeannu eeieaeia?aieeneaiey a aein?aaeao oaea ia yoaia eieoeeaoeee naiaiaeii?aaeeeaeueiuo ?aaeoeee n iineaaeothuei nouanoaaiiui nieaeaieai o?iaiy eco/aaiuo i?iaeoeoia IIE n iaeiia?aiaiiui i?aaeoi?aaeaeaieai oaiaoaiey ooieoeeiie?iaaiey eeth/aauo caaiueaa aioeieneaeaioiie nenoaiu: eaoaeacu e noeueoaeae?eeueiuo a?oii auniei- e ieceiiieaeoey?iuo aeiiieaeoe. E?iia oiai, aeioeaaiiieae i?aaeoi?aaeaeaao eciaiaiey ia?aeeniie onoie/eainoe y?eo?ioeeoia a oneiaeyo ino?ie AeIIE-eioieneeaoeee. Eeth/aaua neiaa: neeeai?, aeeieo?ii?oie?acie, eioieneeaoeey, i?ioeeaeoeea, oieneeieeiaoeea, aioeieneaeaioiay e iiiiieneaaiaciay nenoaiu. N?/aiiaa I.A. Aenia?eiaioaeueia iaa?oiooaaiiy aeei?enoaiiy nee?ai?o aeey i?io?eaeoeee ?ioieneeaoe?e aeei?o?ii?oie?acieii. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.03.05 – oa?iaeieia?y. – ?inoeooo oa?iaeieia?? oa oieneeieia?? AII Oe?a?ie, Ee?a, 1999. A aeena?oaoe?? oai?aoe/ii oa aenia?eiaioaeueii iaa?oioiaaia aeioe?euei?noue aeei?enoaiiy nee?ai?o a yeino? i?io?eaeoe/iiai caniao i?e ?ioieneeaoe?? iio?aeiei 2,4-aeei?o?ioaiieo – aeei?o?ii?oie?acieii (AeIIE). Aea/aii aieea nee?ai?o ia oieneeie?iaoeeo AeIIE a a?ina?aaeiaeuao i?aai?cio oa ooieoe?iiaeueiee noai iiiiieneaaiacii? nenoaie ia/?iee i?e AeIIE-?ioieneeaoe??. Aeiaaaeaia iiaeeo?eoth/a cae?ai?noue a?ioeaaiii?aeo ia e?iaoeeo AeIIE oa ?iaeooee?oth/a iiiiieneaaiacio nenoaio ia/?iee aeoeai?noue ca oiia aino?iai aieeao AeIIE ia i?aai?ci. E??i oiai, aea/aii aieea nee?ai?o ia e?iaoeeo a?eueii?aaeeeaeueieo ?aaeoe?e, i?ioeane e?i?aeia?aieeneaiiy oa noai aioeieneaeaioii? nenoaie i?aai?cio a aeeiai?oe? i?e aino??e ?ioieneeaoe?? AeIIE. Aenia?eiaioaeueii aeiaaaeaia aeioe?euei?noue oa aoaeoeai?noue aeei?enoaiiy nee?ai?o ye aioeieneaeaioa c aaiaoii?ioaeoi?ieie aeanoeainoyie. Anoaiiaeaia aeniea iaia?aiinoaa?e?coth/a aeoeai?noue a?ioeaaiii?aea. Eeth/ia? neiaa: nee?ai?, aeei?o?ii?oie?acie, ?ioieneeaoe?y, i?io?eaeoeea, oieneeie?iaoeea, aioeieneaeaioia oa iiiiieneaaiacia nenoaie. Sichanova E.V. Experimental substantiation of use silibor for preventive maintenance intoxication by dinitroortocresol. - Manuscript. Thesis on competition of a scientific degree of the candidate of medical sciences on a speciality 14.03.05 - pharmacology. - Institute of pharmacology and toxicology AMS of Ukraine, Kiev, 1999. In the dissertation an expediency of utilizations of silibor substantiate theoretically and experimently as remedy of prophylaxis in the intoxication of 2,4-dinitrofenol - dinitroortocresol’s derivative. Besides the action silibor on toxicokinetics of DNOK in biomediums of an organism and functional condition monooxygenase system of a liver for want of DNOK-intoxication’s is investigated. The ability bioflavonoid is proved to render modifying influence to a kinetics DNOK and to induce monooxygenase a system of a liver in conditions of acute action DNOK on an organism. The thesis is devoted to study of influence silibor on a kinetics freeradical of responses, processes lipidperoxidation and condition antioxidant system of an organism in dynamics for want of acute intoxication’s by dinitroortocresol (DNOK). Expediency and effectiveness of use silibor as antioxidant with protector of liver by properties experimentally is proved. Is established high membrane stabilizer activity investigated bioflavonoid, including in a ratio hepatocytar membrane. Key words: silibor, dinitroortocresol, intoxication, prophylaxic, toxicokinetic, antioxidant and monooxygenase system.

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