18

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea

EIAENUe Oaoyia Ieaenaiae??aia

OAeE:616.832-004.2-08

AOAEOEAI?NOUe CANOINOAAIIss

A?IA?AA?E*II? IENEAAIAOe?? OA AAIINI?AOe??

A EIIIEAENIIIO E?EOAAII? OAI?EO

IA ?ICN?ssIEE NEEA?IC

14.01.15 — ia?aia? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao?

?i. I.I. Aiaiiieueoey IIC Oe?a?ie

IAOEIAEE EA??AIEE:

aeieoi? iaaee/ieo iaoe, i?ioani? A?ie/oe Noaiai I?eaio?eiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I. Aiaiiieueoey IIC Oe?a?ie,
eaoaae?a ia?aiaeo oai?ia, caa?aeoaa/ eaoaae?e.

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, i?ioani? Naiinthe ?aai Caoa?iae/, Ee?anueea
iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie,
eaoaae?a o?c?ioa?ai?? oa eo?i?oieia??, caa?aeoaa/ eaoaae?e;

aeieoi? iaaee/ieo iaoe, i?ioani? Iyao Aiaae?ia ?aai?aia, ?inoeooo
ee?i?/ii? ?aae?ieia?? IOe?I AII Oe?a?ie, caa?aeoaa/ a?aeae?eii.

I?IA?AeIA ONOAIIAA:

?inoeooo aa?iioieia?? AII Oe?a?ie, a?aeae?e ee?i?/ii? o?c?ieia?? oa
iaoieia?? ia?aiai? nenoaie (i. Ee?a).

Caoeno a?aeaoaeaoueny “27” o?aaiy 1999 ?ieo i 10-00 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.613.01 i?e Ee?anuee?e
iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie
(254112, i. Ee?a, aoe. Aei?iaiaeeoeueea, 9, aoae. ?3).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueei?
iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie
(i. Ee?a, aoe. Aei?iaiaeeoeueea, 9).

Aaoi?aoa?ao ?ic?neaiee “ 24 ” ea?oiy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiae. iaae. iaoe, aeioeaio I.?. ?iiaiaiei

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue i?iaeaie. ?icn?yiee neea?ic caeia? iaeia c i?ia?aeieo
i?noeue na?aae aeai??e?i?coth/eo caoai?thaaiue oeaio?aeueii? ia?aiai?
nenoaie ethaeeie (J. Hallpike et. al., 1983). Ia oa?eoi??? Oe?a?ie
ca?a?no?iaaii a?eueoa 10 oeny/ oai?eo ia ?icn?yiee neea?ic, 33% c ieo ?
?iaae?aeaie I a?oie, ye? iio?aaothoue noi?iiiueiai iaaeyaeo (N.E.
?aoooaiei oa ni?aaao., 1993; A.A.Caiaaeithe, 1993). O?aaeaiiy in?a
iieiaeiai a?eo, ?iciianthaeaeai?noue oeueiai aaaeeiai caoai?thaaiiy ?
eiai “iiieiaeaeaiiy” ?iaeyoue i?iaeaio aea/aiiy ?N aaaeeeaith ?
aeooaeueiith.

O ca’yceo c a?aenooi?noth ao?io?iiieo cania?a ? iaaecae/aeiith
neeaaei?noth iaoiaaiaco e?eoaaiiy ?icn?yiiai neea?ico aei oaia??oiueiai
/ano ? aeineoue neeaaeiith i?iaeaiith ee?i?/ii? iaa?ieia?? (I.A.
Oiiaeea??ai oa ni?aaao., 1987; TH.I. Naa/aiei oa ni?aaao., 1990; A.I.
Ea?eia, 1992; I.I. ss?io, 1992; I.I. Aecthaa, 1993, 1995; N.E.
?aoooaiei oa ni?aaao., 1993; ?.?. Aon?a oa ni?aaao., 1997; N.I. A?ie/oe
oa ni?aaao., 1995, 1997, 1998; Nieieiaa E.?., 1997, 1998; W. Sibley et
al., 1989; A.F. Helfi, 1994; C.M. Poser, 1997; S.Podobnik et al., 1998).

A?aoiaoth/e iniiai? eaiee iaoiaaiaco, caeeoa?oueny aeooaeueiei
iiaeaeueoa aea/aiiy ii?ooaiue ?ioiii? nenoaie, a?eeiaiai iai?io ?
nenoaie aaiinoaco a ??ci? ia??iaee ia?aa?ao ?N ? i?e ??ciiio nooiai?
eiai oyaeeino? (O.E. Aeueii?ia oa ni?aaao., 1997; Ae.?. Oooeueiai oa
ni?aaao., 1997; I.M.Minderhould, 1994; P.K. Coyle, 1996; P. Stinissen,
1997; M. Blinkerberg et al., 1998). Oea aeanoue iiaeeea?noue ?ic?iaee
iiaeo i?aeoiae?a aei aeeoa?aioe?eiaaiiai e?eoaaiiy oai?eo.

Aeei?enoaiiy ei?oeeinoa?i?ae?a oa ?ioiiiiaeoethth/eo i?aia?ao?a ia
aei?aaaeaei iaae?e ee?i?oeeno?a (A.ss. Ia?ao?i oa ni?aaao., 1991; P.F.
Kirk, 1994; G. Edan, 1997).

Aeey i?aeneeaiiy oa?aiaaoe/ii? aoaeoeaiino? iaaeeeaiaioicii? oa?ai??, a
oaeiae oieeiaiiy iia?/ieo ae?e e?ea?nueeeo cania?a o ee?i?/i?e i?aeoeoe?
ana /ano?oa noaee canoiniaoaaoeny iaiaaeeeaiaioici? iaoiaee e?eoaaiiy:
a?ia?aa?e/ia ieneaaiaoe?y ? aaiini?aoe?y. I?aea?oioyi aeey aeei?enoaiiy
a?ia?aa?e/ii? ieneaaiaoe?? (AAI) a eiiieaeniiio e?eoaaii? ?N ? aeai?
noiniaii iaaeinoaoiino? i?e aeaiiio caoai?thaaii? ee?oeiieo iaoai?ci?a
?ioi?oaoo, ii?ooaiue iaoaaie?cio a?ieia?/ii aeoeaieo ?a/iaei ? ?icaeoie
eaoaioiiai AeAC-neiae?iio.

O e?oa?aoo?? ? iia?aeiieaiiy i?i oni?oia canoinoaaiiy AAI i?e e?eoaaii?
?N o ee?i?eao ?in??, A?ei?on?? oa a e?a?iao aeaeueiueiai ca?oa?aeaey
(A.?. Aieiae?i oa ni?aaao., 1985; O.I. ??iieaiei oa ni?aaao., 1987;
I.A.Eooeueeee, 1992; A.?.Eo?iai oa ni?aaao., 1995; C. Confavreux et al.,
1986; G. Meneghetti et al., 1990; F. Ruscha, 1990; Q.L. Liu, 1994; X.Xu,
1997). Eeoa ie?ai? ioae?eaoe?? ia Oe?a?i? i?enay/ai? canoinoaaiith
oeueiai iaoiaeo e?eoaaiiy i?e ?N (N.E. ?aoooaiei oa ni?aaao., 1993;).
Iaiao?aeii cacia/eoe, ui aei oaia??oiueiai /ano ia ae?iaeai? /?oe?
ia’?eoeai? e?eoa??? eiio?ieth ca ?acoeueoaoaie e?eoaaiiy iaoiaeii AAI.
Ia aeei?enoiaoaaeanue oaeiae iiaeeea?noue i?aeneeaiiy e?eoaaeueii? ae??
eenith a ii?aeiaii? c i?aeoe??iei aaaaeaiiyi aaia?eio a iaeeo aeicao.
Oiio aeineoue aeooaeueiei ? aea/aiiy aoaeoeaiino? oa ?ic?iaea eiie?aoieo
ee?i?ei-eaai?aoi?ieo iieacaiue uiaei canoinoaaiiy AAI a ii?aeiaii? c
aaia?ei?caoe??th a iaeeo aeicao.

Aeoea?caoe?y aooi?ioiieo ?aaeoe?e c iiyaith eeii?a aooi?aaeoeaieo
e?ioioeeo?a oa Oe?E, iaeiie/aiiy a e?ia? i?iaeoeo?a iaoaaie?cio i?e ?N
aea? i?aenoaao aeey oe?ieiai aeei?enoaiiy aaiini?aoe?? (AN) i?e
e?eoaaii? oeueiai caoai?thaaiiy (A.?. O?aueinueeee oa ni?aaao., 1988;
A.?. Aieiae?i oa ni?aaao., 1986; I.I. Nei?iiaoeue oa ni?aaao., 1991;
A.?. Eo?iai oa ni?aaao., 1995; N.Metalnikova et al., 1988).

Iiaeeea?noue aeinyaiaiiy ?ioiinoeioethth/iai aoaeoo oeyoii ii?aeiaiiy AN
c OOI e?ia? i?e e?eoaaii? oai?eo ia ?N aei oaia??oiueiai /ano a
e?oa?aoo?? ia iaaiai?thaaeanue. Oea aeeeoo? iaiao?aei?noue aea/aiiy
aoaeoeaiino? AN a ii?aeiaii? c OOI e?ia? i?e e?eoaaii? oai?eo ia ?N.

Aeineoue ia?niaeoeaiei iai?yieii i?e e?eoaaii? ?N ? ai?iaaaeaeaiiy a
i?aeoeeo iiaiai eeano oa?iaeieia?/ieo i?aia?ao?a, ye? ni?yiiaai? ia
??ci? eaiee iaoiaaiaco. Aei oaeeo i?aia?ao?a iaeaaeeoue a?o/eciyiee
i?aia?ao eaoa?ii — aiaeia Intron et Roferon, ?aaoa?iia oa ?ioeo
aaiii?iaeaia?ieo ?aeiia?iaioieo a-2b-?ioa?oa?ii?a, io?eiaieo oeyoii
eeiioaaiiy aaio ?ioa?oa?iio ethaeeie a aaeoa??yo. Aeiaaaeaia
?ioiiiiaeoethth/a oa i?ioea??onia ae?y i?aia?aoo i?e ??cieo
caoai?thaaiiyo (A.I. ?oaeaiei oa ni?aaao., 1995; A.Ae.Aiae oa ni?aaao.,
1995; A.E. Ai?iioeiaa, 1995). ?acii c oei, a ioae?eaoe?yo inoaii?o ?ie?a
aena?oeth?oueny aeei?enoaiiy ?aaoa?iio oa aaoaoa?iio i?e e?eoaaii?
oai?eo ia ?N (I.I.Aecthaa, 1993; ?.I.Caaae?oei oa ni?aaao., 1996; W.
Cendrowski, 1996; W.J.Clark, 1996; D.C. Mohr, 1996; F.E.Munschauer,
1997). Oiio iiaeaeueoa aea/aiiy ee?i?/ii? aoaeoeaiino? a?o/eciyiiai
i?aia?aoo eaoa?iio a ii??aiyeueiiio aniaeo? c aaceniith oa?ai??th oa
iaiaaeeeaiaioicieie iaoiaeaie i?e e?eoaaii? oai?eo ia ?N i?iaeiaaeo?
caeeoaoeny aeooaeueiei.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa aeeiiaia
ca?aeii iniiaiiai ieaio iaoeiai-aeine?aeii? ?iaioe eaoaae?e ia?aiaeo
oai?ia Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i. I.I. Aiaiiieueoey
“Aea/aiiy aoaeoeaiino? ??cieo iaoiae?a e?eoaaiiy oai?eo ia ?icn?yiee
neea?ic ? ?ic?iaea ia oe?e iniia? iiaeo i?aeoiae?a aei
aeeoa?aioe?eiaaiiai e?eoaaiiy caoai?thaaiiy” oeo? 111.26.00.027.24 ?
aea?ae?a?no?aoe?? 0194V017984.

Iaoa aeine?aeaeaiiy: aecia/eoe aoaeoeai?noue canoinoaaiiy a?ia?aa?e/ii?
ieneaaiaoe?? oa aaiini?aoe?? a eiiieaeniiio e?eoaaii? oai?eo ia ?N o
ii??aiyii? c iaaeeeaiaioiciith oa?ai??th a caeaaeiino? a?ae ee?i?/iiai
ia?aa?ao, nooiaiy oyaeeino?, iniaeeainoae ?ioiiiai noaoono oa
a?io?i?/ieo ii?ooaiue.

Caaea/i aeine?aeaeaiiy:

1. Aea/eoe iniaeeaino? ee?i?/iiai ia?aa?ao ?N a caeaaeiino? a?ae oi?ie,
nooiaiy oyaeeino? oa o?eaaeino? caoai?thaaiiy c o?aooaaiiyi aaeueii?
ioe?iee iaa?ieia?/ieo ii?ooaiue ca NRS oeaeith.

2. Ioe?ieoe iniaeeaino? ?ioiiiai i?io?eth, aeayeeo a?io?i?/ieo
ia?aiao??a, nenoaio aaiinoaco o oai?eo ia ?N o aca?iica’yceo c oeiii
ia?aa?ao, nooiaiai oyaeeino? oa o?eaae?noth caoai?thaaiiy.

3. Aecia/eoe aoaeoeai?noue canoinoaaiiy AAI a ii?aeiaii? c iaeeie
aeicaie aaia?eio a eiiieaeniiio e?eoaaii? oai?eo ia ?N.

4. Aea/eoe aoaeoeai?noue canoinoaaiiy AN a ii?aeiaii? c OOI e?ia? i?e
eiiieaeniiio e?eoaaii? oai?eo ia ?N.

5. Aeine?aeeoe aoaeoeai?noue canoinoaaiiy i?aia?aoo eaoa?ii a
eiiieaeniiio e?eoaaii? oai?eo ia ?N.

6. I?iaanoe aiae?c oa?aiaaoe/ii? aoaeoeaiino? iaiaaeeeaiaioicieo
iaoiae?a e?eoaaiiy a ii??aiyii? c eaoa?iiii ? aaceniith oa?ai??th.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

1. Aia?oa o oai?eo ia ?icn?yiee neea?ic (?N) aeaoaeueii aea/ai?
iniaeeaino? nenoaie aaiinoaco oa ??aiy na?aaei?o iieaeoe o aca?iica’yceo
c oeiii ia?aa?ao, nooiaiai oyaeeino? oa o?eaae?noth caoai?thaaiiy.

2. Ae?noaei iiaeaeueoiai ?icaeoeo aea/aiiy iniaeeainoae ?ioiiiai
i?io?eth c aeyaeaiiyi aeenaaeaino ?ioiieiiiaoaioieo ee?oei o caeaaeiino?
a?ae ee?i?/iiai ia?aa?ao, nooiaiy oyaeeino? oa o?eaaeino? caoai?thaaiiy.

3. Aia?oa aeaia ioe?iea oa?aiaaoe/ii? aoaeoeaiino? a?ia?aa?e/ii?
ieneaaiaoe?? a ii?aeiaii? c iaeeie aeicaie aaia?eio, aaiini?aoe?? a
ii?aeiaii? c OOI e?ia? a ii??aiyii? c iaaeeeaiaioiciith oa?ai??th i?e
??cieo oeiao ia?aa?ao oa nooiaiyo oyaeeino? ?N.

4. Aia?oa iaa?oioiaaiee aeeoa?aioe?eiaaiee i?aeo?ae aei i?ecia/aiiy
a?ia?aa?e/ii? ieneaaiaoe?? oa aaiini?aoe?? oai?ei ia ?N.

5. Aia?oa aecia/ai? iniiai? ee?i?ei-?ioiieia?/i? e?eoa??? i?ecia/aiiy
i?aia?aoo eaoa?ii i?e ?N c ai?iaaaeaeaiiyi a ee?i?/io i?aeoeeo aeaiiai
niiniao oa?ai??.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Ia i?aenoaa?
ee?i?ei-?ioiieia?/ieo, ee?i?ei-a?io?i?/ieo ia?aiao??a ?ic?iaeai?
aeeoa?aioe?eiaai? i?aeoiaee aei i?ecia/aiiy a?ia?aa?e/ii? ieneaaiaoe?? a
ii?aeiaii? c iaeeie aeicaie aaia?eio, aaiini?aoe?? a ii?aeaiii? c OOI
e?ia? a eiiieaeniiio e?eoaaii? oai?eo ia ?N. Aeiaaaeaia iaiao?aei?noue
aeeth/aiiy i?aia?aoo eaoa?ii aei i?ia?aie eiiieaenii? oa?ai?? oai?eo c
ii/aoeiaeie noaae?yie ?N ?ai?ooth/ei ia?aa?aii ? i?eai?/aiiyi
O-ee?oeiii? eaiee ?ioi?oaoo. ?ic?iaeai? ee?i?ei-eaai?aoi?i? e?eoa???
aoaeoeaiino? canoinoaaiiy aeaieo iaoiaeee.

?acoeueoaoe ianoaaeaiue ? iaoiaee e?eoaaiiy ai?iaaaeaeai? a i?aeoeeo
?iaioe iaa?ieia?/ieo a?aeae?eaiue Oe?EE ?4, Oe?EE ?18, OeIEE i. Ee?aa,
Aieeinueei? IEE, a?aeae?eaiiy ?aai?iaoe?? Oe?EE ?4. Iaoa??aee ?iaioe
ai?iaaaeaeai? a o/aiaee i?ioean eaoaae?e ia?aiaeo oai?ia, ?aai?iaoieia??
oa iaaeeoeeie eaoano?io IIO. Ai?iaaaeaeaiiy i?aeoaa?aeaeai?
a?aeiia?aeieie aeoaie.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaiae?ciaaii aeecueei
400 i?ei??iee?a no/anii? iaoeiai? e?oa?aoo?e ii oai? aeena?oaoe??,
i?iaaaeaiee iaoaioii-?ioi?iaoe?eiee iiooe, eiiieaenia ee?i?/ia,
?ioiieia?/ia oa a?io?i?/ia ianoaaeaiiy oai?eo. Ca?? aeaieo, ia?iaeo
ia?aeiii? aeieoiaioaoe??, ee?i?/iee i?aea?? oai?eo oa i?aeaioiaeo
iaoa??aeo aeey a?io?i?/ieo, ?ioiieia?/ieo aeine?aeaeaiue, a oaeiae
aecia/aiiy ??aiy NI i?iaiaeeeeny aaoi?ii naiino?eii. Ca
aaciina?aaeiueith o/anoth i?iaaaeai? ?ioiieia?/i? oa ?io? a?io?i?/i?
ianoaaeaiiy oai?eo ia aac? Oe?a?inueeiai oeaio?o ee?i?/ii? ?ioiieia??
IIC Oe?a?ie oa a?io?i?/ii? eaai?aoi??? Oe?EE ?4, ?ic?iaeai? iaoiaee
e?eoaaiiy. Noaoenoe/ia ia?iaea ?acoeueoao?a i?iaaaeaia aaciina?aaeiuei
aaoi?ii. Aiae?c io?eiaieo ?acoeueoao?a, ii??aiyiiy c aeaieie e?oa?aoo?e,
iaienaiiy ?icae?e?a aeena?oaoe?? oa aeniiae?a aeeiiai? naiei aaoi?ii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Aeena?oaoe?y ai?iaiaaia ?
?aeiiaiaeiaaia aei caoenoo ia can?aeaii? ai?iaaoe?eii? ?aaee “Ia?aia?
oai?iae ? ineo?ao??y” ca o/anoth /eai?a ?aaee, ni?a?ia?oiee?a eaoaae?e
ia?aiaeo oai?ia, ineo?ao???, aianoac?ieia??, ?aai?iaoieia?? ? iaaeeoeeie
eaoano?io Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i. aeaae. I.I.
Aiaiiieueoey. Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ia VIII
?anioae?eainueeiio c’?cae? iaa?iiaoieia?a ? ineo?ao??a (i. Oa?e?a,
10.10.90), i?nuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? iaa?iiaoieia?a ?
ineo?ao??a “Aeooaeuei? ieoaiiy iaoiaaiaco ? e?eoaaiiy noaeeiieo ?
aeai??e?i?coth/eo caoai?thaaiue ia?aiai? nenoaie” (i. Ee?a, 06.06.95),
ia 29 I?aeia?iaeiiio Aeoiaenueeiio neiiic?oi? (i. Aeoa?iaiee,
07.11.-08.11.1997), I Iaoe?iiaeueiiio eiia?an? iaa?iiaoieia?a ?
ineo?ao??a (i. Oa?e?a, 20.05.-23.05.1997), II I?aeia?iaeiiio iaaee/iiio
eiia?an? nooaeaio?a ? iieiaeeo a/aieo (i. Oa?iii?eue,
06.05.-08.05.1998).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 9 iaoeiaeo
i?aoeue, o oiio /ene? 8 iniaenoi. Na?aae ieo — 4 noaoo? a iaoeiaeo
aeo?iaeao, 3 c yeeo — aac ni?aaaoi??a, 2 — o ca??ieeao iaoeiaeo i?aoeue,
3 oac?a aeiiia?aeae.

No?oeoo?a ? ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 150 noi??ieao
ae?oeiaaiiai oaenoo, neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e,
caaaeueii? oa?aeoa?enoeee oai?eo, iaoiae?a ?o ianoaaeaiiy ? e?eoaaiiy,
aeaio aeaa aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo e?oa?aoo?e (145 a?o/eciyieo, 83 ca?oa?aeieo
i?ei??ieee). ?iaioa ?ethno?iaaia 30 oaaeeoeyie, 23 ?enoieaie.

Ci?no ?iaioe

Iaoa??ae, iaoiaee aeine?aeaeaiiy ? e?eoaaiiy. Aeey aeinyaiaiiy
iinoaaeaii? o ?iaio? iaoe ? caaaeaiue aoa ianoaaeaiee 101 oai?ee ia ?N.
A?e ianoaaeaieo eieeaaany a?ae 16 aei 55 ?ie?a, o oiio /ene? aei 20
?ie?a aoei 15 oai?eo (14,8%), a?ae 20 aei 29 ?ie?a — 40 (39,6%), a?ae 30
aei 39 ?ie?a — 27 (26,7%), a?ae 40 aei 49 ?ie?a — 11 (10,8%), noa?o? 50
?ie?a — 8 oai?eo (7,9%). Oaeei /eiii, iaea?eueoa e?euee?noue oai?eo aoea
o a?oe? 20-29 ?ie?a (39,6%) oa 30-39 ?ie?a (26,7%). *ieia?e?a aoei 57, a
ae?iie — 44. Ca o?eaae?noth caoai?thaaiiy oai?? aoee ?iciiae?eai? oaeei
/eiii: aei 1 ?ieo — 14 oai?eo, a?ae 1 aei 3 — 23, a?ae 3 aei 5 — 22,
a?ae 5 aei 10 — 26, a?eueoa 10 ?ie?a — 16 oai?eo. Ioaea, eeoa o 14
oai?eo i?e aini?oae?caoe?? aei iaa?ieia?/iiai noaoe?iia?o o?eaae?noue
caoai?thaaiiy aoea a iaaeao iaeiiai ?ieo, o 45 oai?eo — a?ae 1 aei 5
?ie?a.

Ianoaaeaiiy oai?eo ia ?N i?iaiaeeee ca ?aeeiith noaiith c aeei?enoaiiyi
oi?iae?ciaaieo ea?o. An? oai?? iaee aacnoii?aiee ae?aaiic ca e?eoa??yie
I.A. Oiiaeea??aia (1987).

I?iaiaeeeinue aeaoaeueia iaa?ieia?/ia ianoaaeaiiy ?c caeo/aiiyi iaoiae?a
niaoe?aeueiiai ia?aee?i?/iiai aeine?aeaeaiiy aino?ioe ci?o, i/iiai aeia
oa iie?a ci?o, a ie?aieo aeiaaeeao — yaea?ii-iaai?oii-?ac?iainii?
oiiia?ao?? aieiaiiai iiceo. Ae?aaeai?noue iaa?ieia?/ieo neiioii?a
ioe?ithaaee ca oeaeith NRS, cai?iiiiiaaiith J. Sipe et al. (1984), o
aaeao. Iaeneiaeueia e?euee?noue aae?a — 100 na?ae/eea i?i a?aenooi?noue
ci?i o iaa?ieia?/iiio noaoon?; a?ae 70 aei 98 — i?i iaa?ieia?/i?
ii?ooaiiy eaaeiai nooiaiy oyaeeino?; a?ae 40 aei 69 — i?i iaa?ieia?/i?
ii?ooaiiy na?aaeiueiai nooiaiy oyaeeino?; a?ae 10 aei 39 — i?i oyaee?
iaa?ieia?/i? ii?ooaiiy.

Aeine?aeaeoaaany ??aaiue a?eea oi?o?eiaaiei iaoiaeii ca a?o?aoaiiaith
?aaeoe??th oa eiai o?aeoe?e ca A.?. Ao?a?/ai (1972). ??aaiue na?aaei?o
iieaeoe (NI) aecia/aee ca iaoiaeii I.?. Aaa???eyi (1985), a iniia? yeiai
eaaeeoue aaeueo?eueo?aoe?eia ?iciiae?eaiiy ieacie, ? ioe?ithaaee oeyoii
aeaoaeoe?? ia niaeo?ioioiiao?? NO-26 “Eiii” a oiiaieo iaeeieoeyo (IAe).

Aecia/aee oaeiae e?euee?noue o?a?eiiaaio a ieaci? e?ia?, oiea?aioi?noue
ieacie aei aaia?eio iaoiaeii Aa?inaia, aeoea?ciaaiee /an noaa?e?ciaaii?
ieacie, i?iaiaey/e ?aaeoe?th ?aeaeueoe?o?eaoe?? ? i?iaeoeoe o?a?eiie?co,
a?aoiaoth/e iayai?noue o?a?eiiaaio A oa ca aeiiiiiaith aoaiieiaiai
oanoo.

E?euee?noue O- ? A-e?ioioeeo?a aecia/aee ca ?o caeaoi?noth ooai?thaaoe
?icaoee c a?eo?ioeeoaie aa?aia ca iaoiaeeeaie S. Stell (1974) ? A.
Basten (1972). Noaiiioeyoe?? O-ee?oei O-oaeia?e ? O-noi?ani?e aecia/aee
ca iaoiaeii Shre A. et al. (1978) ia i?aenoaa? a?aeiioaiiy aei
oaio?e?io, O-noi?ani?e — oaio?e?i/ooeea?, O-oaeia?e —
oaio?e?i?acenoaioi?. Ai?no iniiaieo eean?a ?ioiiaeiaoe?i?a aecia/aee
iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? (G. Mancini, 1965). Aeey aecia/aiiy
oee?eoethth/eo ?ioiieo eiiieaen?a aeei?enoiaoaaee iaoiae, iniiaaiee ia
?o naeaeoeai?e i?aoeei?oaoe??.

O caeaaeiino? a?ae canoiniaaieo iaoiae?a e?eoaaiiy an? ianoaaeai? oai??
aoee ?iciiae?eai? ia /ioe?e a?oie. Eiio?ieueia a?oia aeeth/aea 30 oai?eo
ia ?N c aeei?enoaiiyi o?aaeeoe?eii? (aacenii?) oa?ai?? ca noaiith,
?ic?iaeaiith ia eaoaae?? ia?aiaeo oai?ia IIO.

Aei ia?oi? a?oie iaeaaeaa 41 oai?ee ia ?N. Aeey e?eoaaiiy ?i
canoiniaoaaee a?ia?aa?e/io ieneaaiaoe?th (AAI), yeo i?iaiaeeee a
iaeiii?ni?e aa?ieaia?? oeio “Iea” c ?aaeeiii ?cii?an?? 1,6 — 1,7 Aoa,
aeniiceoe??th 50-60 oaeeei. Ia eo?n e?eoaaiiy i?ecia/aee 10 naain?a.
E??i eo?no e?eoaaiiy AAI c iaoith iie?auaiiy ?aieia?/ieo aeanoeainoae
e?ia? aaiaeeee aaia?ei aeicith 5000 IAe i?aeoe??ii a iaaeieiioieiao
ae?eyieo o?e/? ia aeiao aai aeicith 2500 IAe /ioe?e ?ace ia aeiao i?ae
eiio?ieai /ano cai?oaiiy e?ia?.

Ae?oao ee?i?/io a?oio neeaaeaee 10 oai?eo ia ?N, yeei a eiiieaeniiio
e?eoaaii? canoiniaoaaee aaiini?aoe?th a ii?aeiaii? c OOI e?ia?.
Aaiini?aoe?th i?iaiaeeee ia aia?ao? OAA-1 ca aaii-aaiiciei eiioo?ii. Ie
aeei?enoiaoaaee ni?aaioe NEI-1E, EAO oa ea?aieie. Anueiai ia eo?n oai??
io?eioaaee 3 naaine aaiini?aoe?? /a?ac aeaiue. I?ae naainaie AN oai?ei
i?iaiaeeee o?aeoe?eii oeueo?ao?ieaoiaa ii?ii?iaiiy e?ia? ia aia?ao?
“Oioii” i?e aeiaaeei? oaee? 254 ii i?ioyaii 2 aiaeei. Ca iaeei naain
a?aee 100-120 ie e?ia?.

O?aoy ee?i?/ia a?oia aeeth/aea 20 oai?eo, yeei a eiiieaeniiio e?eoaaii?
i?ecia/aee eaoa?ii. I?aia?ao aaiaeeee aioo??oiueii’yciai aeicith 1 iei.
IAe aea?/? ia aeiao i?ioyaii 20 aei?a.

Eiio?ieueio a?oio i?e eaai?aoi?ieo aeine?aeaeaiiyo neeaaeaee 20
ianoaaeaieo (12 /ieia?e?a ? 8 ae?iie), a?eii a?ae 18 aei 35 ?ie?a aac
ee?i?/ieo iciae i?aai?/iiai o?aaeaiiy oeaio?aeueii? ia?aiai? nenoaie.

Ee?i?/i? a?oie aoee ii??aiyi? ca aeaiia?ao?/ieie iieacieeaie, nooiaiai
oyaeeino? caoai?thaaiiy, a oaeiae ae?aaeai?noth iaa?ieia?/iiai
aeao?oeeoo ca oeaeith NRS.

Ioe?ieo aoaeoeaiino? oa?ai?? cae?enithaaee ca nenoaiith:

— cia/ia iie?auaiiy, eiee ?aa?an iaa?ieia?/ii? neiioiiaoeee a?aeaoaaany
ia 20 aae?a ? a?eueoa ca noiaaeueiith oeaeith NRS (Sipe J. at al., 1984)
, c iiceoeaiith aeeiai?eith eaai?aoi?ieo iieaciee?a (I i?aea?oia);

— iii??ia iie?auaiiy — o aeiaaeeao ?aa?ano iaa?ieia?/ii? neiioiiaoeee < 20 aae?a ? iie?ioaiiy aeayeeo eaai?aoi?ieo iieaciee?a (II i?aea?oia); - e?eoaaiiy aac aoaeoo, eiee a?aeiiaeaiiy iaa?ieia?/ieo ooieoe?e ia niinoa??aaeinue, ia ?a?no?oaaeenue oaeiae iiceoeai? ci?ie eaai?aoi?ieo ia?aiao??a (III i?aea?oia). ?acoeueoaoe aeine?aeaeaiue aoee noaoenoe/ii ia?iaeai? iaoiaeaie aa??aoe?eii? noaoenoeee c aeei?enoaiiyi e?eoa??th Nouethaeaioa ia i?e?i-AII “Aeaeo?ii?ea IE-61”. ?acoeueoaoe aeanieo aeine?aeaeaiue Ca ?acoeueoaoaie i?iaaaeaieo aeine?aeaeaiue aoee aeae?eai? o?e iniiai? ee?i?/i? oi?ie ?N: oea?aa?i-ni?iaeueia (63,4%), ni?iaeueia (19,8%) ? oea?aa?aeueia (16,8%), a ?aieao oea?aa?aeueii? oi?ie - i/iee ? iici/eiaee aa??aioe. Aeae?eaiiy o??? /e ?ioi? oi?ie caoai?thaaiiy ia ia??iae ianoaaeaiiy oai?iai a?oiooaaeinue ia ia?aaaaeaii? iaa?ieia?/ieo ii?ooaiue, a ie?aieo aeiaaeeao - eieae?caoe?? aeai??e?i?coth/eo ina?aaee?a ca aeaieie iaai?oii-?aciiainii? oiiia?ao??, oi/a a aeayeeo ianoaaeaieo (5) aiie aeyaeeenue noaee?i?/ieie. Oiio eia?/ii, ui oai?? c oea?aa?i-ni?iaeueiith oi?iith ?N iaee a?eueo ae?aciee iaa?ieia?/iee aeao?oeeo o ii??aiyii? c oea?aa?aeueiith oa ni?iaeueiith oi?iaie caoai?thaaiiy. Oei ia?aa?ao ?N ia? aaaeeeaa cia/aiiy aeey aeai?o aeeoa?aioe?eiaaii? oa?ai??. Na?aae a?oie oai?eo ?ai?ooth/ei oeiii ia?aa?ao (58,4%) ie aeae?eeee ?ai?ooth/i-i?ia?anoth/ee (27,7%) ? aeia?iye?niee (2,97%) aa??aioe. I?e i?ia?anoth/iio oei? ia?aa?ao (41,5%) caa?oaee oaaao ia eiai ia?aeii?noue (19,8%) /e aoi?eii?noue (21,9%). Aiae?coth/e aa??aioe ia?aa?ao ?N o eiaeiiai ie?aiiai oai?iai, ie ia?aeiiaeenue, ui oei ia?aa?ao iiaea ci?ithaaoenue ? eiai aecia/aiiy a?aeiia?aea? ee?i?/i?e neooaoe?? ia iiiaio ianoaaeaiiy iaoe??ioa. Naia oei iiaeia iiynieoe ??ci? aeai? e?oa?aoo?e uiaei /anoioe ??cieo aa??aio?a ia?aa?ao. Ie aecia/eee oaeiae, ui o?e /e ?io?e ee?i?/i?e oi?i? caoai?thaaiiy a?aeiia?aea? iaea?eueo oa?aeoa?iee oei ia?aa?ao: oea?aa?i-ni?iaeuei?e - ?ai?ooth/ee, /ano?oa oea ?ai?ooth/i-i?ia?anoth/ee aa??aio, ni?iaeuei?e - i?ia?anoth/ee, aeey oea?aa?aeueii? oi?ie /anoioa aeyaeaiiy ??cieo aa??aio?a ia?aa?ao nooo?ai ia a?ae??ciyeanue. A?eueo aeaoaeueii nooi?iue ae?aaeaiino? iaa?ieia?/iiai aeao?oeeoo i?e ??cieo oeiao ia?aa?ao, eiai aa??aioao ? nooiai? oyaeeino? caoai?thaaiiy aeiiiiaaaea ioe?ieoe noiaaeueia oeaea NRS. Oae, i?e nooiaiyo oyaeeino? caoai?thaaiiy a?ae I ii V, ae?aaeai?noue iaa?ieia?/iiai aeao?oeeoo aoea a iaaeao 34,1±1,7 ? 81,2±2,3 aae?a. O oai?eo ?ai?ooth/ei ia?aa?aii iaa?ieia?/iee noaoon ioe?ithaaany o 46,2±3,2 aaee, a i?ia?anoth/ei - 50,2±3,1 aaee. Nooo?a? a?aei?iiino? niinoa??aaeenue o?eueee i?e ioe?ioe? aa??aio?a ia?aa?ao (i?e ?ai?ooth/i-i?ia?anoth/iio aa??aio? iaa?ieia?/iee aeao?oeeo neeaaeaa 38,2±2,5 aaee, i?e aeia?iye?niiio - 72,3±1,5 aaee). Oe? aeai? aeiiiiaaathoue i?e ioe?ioe? aeeiai?ee iaoieia?/iiai i?ioeano, eiai i?iaiicoaaii?, ui, ia iaoo aeoieo, iaoeia aaaeeeaa cia/aiiy aeey aeai?o i?ia?aie e?eoaaiiy oai?eo. O ca’yceo c ??ciiiai?aaeai?noth ?ioiiiaoieia?/ieo ci?i i?e ?N aeine?aeaeaiiy ?ioiiiai noaoono ia? ia?oi/a?aiaa cia/aiiy aeey ?ic?iaee aoaeoeaieo iaoiae?a e?eoaaiiy oai?eo ia ?N. Oiio ie aaaaeaee aeioe?eueiei aea/eoe ?ioiiee noaoon oai?eo ia ?N o caeaaeiino? a?ae oeio ia?aa?ao, eiai oace, nooiaiy oyaeeino? oa o?eaaeino? caoai?thaaiiy. Aeyaeee, ui e?euee?noue O-e?ioioeeo?a o oai?eo ia ?N o noaae?? ?ai?n?? i?e ?ai?ooth/iio ia?aa?ao nooo?ai ia ci?ithaaeanue (46±3%; 610±25; p>0,05). E?euee?noue Oe cieaeoaaeanue aeinoia??ii eeoa a noaae??
caaino?aiiy (32±2%; 546±20; p<0,05). Iaea?eueo ae?aaeaia O-e?ioiiai?y niinoa??aaeanue i?e i?ia?anoth/iio ia?aa?ao ?N (30±2%; p<0,001; 445±21; p<0,01). I?e c?inoaii? oyaeeino? oa o?eaaeino? caoai?thaaiiy e?euee?noue Oe oaeiae i?ia?aneaii ciaiooaaeanue. Ioe?ieo noaio ee?oeiiiai ?ioi?oaoo ia iiaeia i?iaanoe aac aea/aiiy e?eueeino? noaiiioeyoe?e O-e?ioioeeo?a - Oo ? On, ?o aeenaaeaino. Ca aeaieie iaoeo aeine?aeaeaiue, iaea?eueo ae?acii a noaae?? caaino?aiiy i?e ?ai?ooth/iio ia?aa?ao cieaeoaaeanue e?euee?noue Oo (21±2%; 300±23; p<0,05), a On - i?e i?ia?anoth/iio ia?aa?ao (8±0,4%; 120±6; p<0,05). ? oi/a cieaeaiiy ??aiy Oo o ianoaaeaieo oai?eo aeyaeyeinue aaea ia ?aii?o noaae?yo caoai?thaaiiy ? i?e eaaoeo eiai nooiaiyo, ?o ciaioaiiy ie aaaaea?ii i?iaiinoe/ii iaio iani?eyoeeaei o ii??aiyii? c iaae?iiyi On. Oae? ci?ie, ia iaoeie aeaieie, aeieeaee o oai?eo o a?eueo i?ci? no?iee, c o?eaae?noth caoai?thaaiiy a?eueoa o?ueio ?ie?a, i?e c?inoaii? eiai nooiaiy oyaeeino?. Oea iiaeia iiynieoe oei, ui i?ia?anoaaiiy caoai?thaaiiy oa eiai o?ii?caoe?y iia’ycai? c i?eai?/aiiyi naia O-noi?ani?ii? noaiiioeyoe?? ? aeeaoei ?icaeoeii aooi?ioiieo ii?ooaiue. A eiai caaino?aiiy iiaea a?aeaoaaoenue i?e oeeee?/ieo ci?iao aooi?ioiiiai ? ?ioiiaeao?oeeoiiai noai?a ? a?eueoiio cieaeaii? ??aiy Oo. Aeey ioe?iee nooiaiy i?ia?aae??ioiino? caoai?thaaiiy oa eiai aino?ioe ia? cia/aiiy oaeiae oaeee iieaciee ye oaaioeeoa?iee ?iaeaen, eio?ee neoaeeoue aeey ioe?iee ooieoe?iiaeueiiai noaio iaeo?io?e?a ? i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino?. O? ciaiooaaany a noaae?? caaino?aiiy i?e ?ai?ooth/iio ia?aa?ao (aei 39±2%, p<0,05) ? i?e c?inoaii? nooiaiy oyaeeino? caoai?thaaiiy (p<0,05). Cieaeaiiy oaaioeeoa?iiai ?iaeaeno a noaae?? caaino?aiiy iiaeia iiynieoe c?inoaiiyi aooi?ioiieo i?iya?a ? aeieoaaiiyi ?aoeaioi??a iaeo?io?e?a oee?eoethth/eie a e?ia? ?ioiieie eiiieaenaie ? cieaeaiiyi i?e?iaeii? aioe?ioaeoe?eii? ?acenoaioiino? aiane?aeie eiioaeoo c eiia??iei a??oniei caoaeieeii. Iieacieee aoii?aeueiiai ?ioi?oaoo a?aoiaoaaeenue i?e ioe?ioe? aeoeaiino? iaoieia?/iiai i?ioeano oa iiaiioe aeinyaiooi? ?ai?n??. Iaea?eueoa c?inoaiiy A-e?ioioeeo?a (35±2,8%, 420±25, p<0,05), Oe?E (0,14±0,021, p<0,05) ie aeyaeee o oai?eo i?e caaino?aii? caoai?thaaiiy. Ie io?eiaee oaeiae iaea?eueoa i?aeaeuaiiy Ig G a noaae?? caaino?aiiy (aei 14,3±0,63, p<0,05), ui iiynith?oueny c oi/ee ci?o ?ioiiaaiaco ?o oaeaeoei neioacii i?e i?enooiino? aioeaaio a e?ia? (aoi?eii?e ?ioii?e a?aeiia?ae?) oa a?eueoei ia??iaeii iieo?iciaaeo o ii??aiyii? c Ig M. Oaeei /eiii, noeoii?noue ?ioiieia?/ieo aeine?aeaeaiue iaiao?aeii a?aoiaoaaoe i?e ioe?ioe? aino?ioe, oa?aeoa?o, nooiaiy i?ia?aae??ioiino? oa eiiiainaoe?? aeai??e?i?coth/iai i?ioeano. Aiie iathoue neoaeeoe iaeieie c iniiaieo eaai?aoi?ieo e?eoa???a aoaeoeaiino? iaoiae?a e?eoaaiiy. Aeyaeai? ci?ie a?eeiaiai iai?io aeacoaaee ia c?inoaiiy iaoaaie?/ieo ii?ooaiue o i??e?iia?e iaieiioe? ? a i?aai?ci? a oe?eiio. Ca iaoeie aeaieie, caaaeueiee ??aaiue a?eea caeeoaany o iaaeao ii?ie. Aiae?coth/e ??aaiue a?eeiaeo o?aeoe?e, ie aeyaeee iciaee aeenaeiaoe?iai??: cieaeaiiy a2-o?aeoe?? ia aoei nooo?aei (aei 8,0±1,0%; p. >0,05), aea aeinoia??ii
i?aeaeuoaaany ??aaiue g-aeiaoe?iiai? o?aeoe?? (aei 20,3±1,5%; p<0,05). Oe? ii?ooaiiy iaea?eueo ae?aaeaieie aoee a noaae?? caaino?aiiy. Naia o oai?eo oe??? eaoaai??? niinoa??aaeinue cia/ia i?aeaeuaiiy ??aiy Ig G. Oeei i?aeoaa?aeaeo?oueny iieiaeaiiy i?i oa, ui naia o?aeoe?y g-aeiaoe?i?a neeaaea?oueny ia?aaaaeii c ?ioiiaeiaoe?i?a. Caneoaiao? ia oaaao aea/aiiy iieaciee?a, ye? a?aeia?aaeathoue iayai?noue eaoaaie?/ieo i?ioean?a o i??e?iia?e iaieiioe? ? a i?aai?ci? a oe?eiio - iaioeae?a na?aaeiuei? iieaeoey?ii? iane. Aei na?aaei?o iieaeoe ye iieaciee?a “iaoaaie?/ii? ?ioieneeaoe??” a i?aai?ci? ca inoaii? ?iee i?eaa?iooa oaaaa aaaaoueio aeine?aeiee?a. ?o ??aaiue aea/aany i?e ??cieo caoai?thaaiiyo, aino?eo ?ioieneeaoe?yo ? ia aeine?aeaeoaaany i?e ?icn?yiiio neea?ic?. Ie aeyaeee ci?ie ??aiy NI o 38 oai?eo ia ?N. O noaae?? caaino?aiiy ??aaiue NI ca?eueooaaany a 2,5 ?ace ii??aiyii c eiio?ieai (0,620±0,16 IAe, p<0,05). Iaioa oeae iieaciee c?inoaa i?e i?ia?anoth/iio ia?aa?ao. ??aaiue NI ca?eueooaaany oaeiae i?e i?ia?anoaaii? ?N, a oaeiae c?inoaii? nooiaiy oyaeeino? caoai?thaaiiy (p<0,05). Oiaoi, i?aeneeaiiy eaoaaie?/ieo i?ioean?a o aiaieuao aeai??e?i?caoe?? ia aieeaa? ia ??aaiue caaaeueiiai a?eea. Oiio NI, ye? a?aeia?aaeathoue oe? ii?ooaiiy, iiaeooue neoaeeoe aeiaeaoeiaei ? aaaeeeaei eaai?aoi?iei e?eoa???i aeey aeai?o iaoiae?a oa?ai?? ? ioe?iee aoaeoeaiino? e?eoaaiiy. A?aoiaoth/e aca?iica’ycie nenoai ?ioi?oaoo ? aaiinoaco, ie aaaaeaee aeioe?eueiei aea/eoe aaii?aieia?/i? iieacieee o oai?eo ia ?N c o?aooaaiiyi oeio ia?aa?ao, eiai oace ? nooiaiy oyaeeino? caoai?thaaiiy. Iao? aeai? iieacothoue, ui a noaae?? caaino?aiiy caoai?thaaiiy aeyaeythoueny iciaee AeAC-neiae?iio, i?i ui na?ae/eei aeinoia??ia i?aeaeuaiiy ??aiy o?a?eiiaaio (aei 8,3±0,8 a/e, p<0,05), i?aeaeuaiiy oiea?aioiino? aei aaia?eio (aei 3,6±0,3 oa., p<0,05) ? iiyaa i?iaeoeo?a aeaa?aaeaoe?? o?a?eiiaaio (o?a?eiiaai A, iiceoeaiee aoaiieiaee oano). Oaeei /eiii, aeoeai?noue aeai??e?i?coth/iai i?ioeano ? nooi?iue eiai eiiiainaoe?? iiaeia ioe?ithaaoe c o?aooaaiiyi ia?aiao??a eiaaoeia?aie, a aeyaeai? iciaee eaoaioiiai AeAC-neiae?iio c i?aeaeuaiiyi o?a?eiiaaio ? i?iaeoeo?a eiai aeaa?aaeaoe?? iiaeooue neoaeeoe e?eoa???i aeey aeai?o iaoiae?a e?eoaaiiy. Oae? iniaeeaino? oa caaaeuei? caeiiii??iino? ?ioii-aaii?aieia?/ieo ? iaoaaie?/ieo ii?ooaiue i?e ??cieo oeiao ia?aa?ao, noaae?yo ? nooiaiyo oyaeeino? caoai?thaaiiy iaie aoee aeyaeai?. A?aoiaoth/e aeai? i?iaaaeaieo aeine?aeaeaiue, ie i?iaaee aiae?c aoaeoeaiino? canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? a ii?aeiaii? c iaeeie aeicaie aaia?eio (I a?oia), aaiini?aoe?? a ii?aeiaii? c OOI e?ia? (II a?oia) oa eaoa?iio (III a?oia) a ii??aiyeueiiio aniaeo? c aaceniith oa?ai??th (a?oia eiio?ieth). Oaeei /eiii, an? ianoaaeai? aoee ?iciiae?eai? ia 4 a?oie. O caeaaeiino? a?ae ?acoeueoao?a e?eoaaiiy a iaaeao eiaeii? a?oie aoee aeae?eai? 3 i?aea?oie: I oa - cia/ia iie?auaiiy, II aa - iii??ia iie?auaiiy, III y - e?eoaaiiy aac aoaeoo. Ie aea/eee aoaeoeai?noue canoinoaaiiy AAI a ii?aeiaii? c iaeeie aeicaie aaia?eio i?e e?eoaaii? 41 oai?iai ia ?N. Aiae?c ?acoeueoao?a e?eoaaiiy iieacaa, ui iaeaea o iieiaeie oai?eo oe??? a?oie (48,8% ianoaaeaieo) niinoa??aaeinue cia/ia iie?auaiiy c /anoeiaei, a a aeayeeo aeiaaeeao - iiaiei ?aa?anii i?aeoe/ii an?o iaa?ieia?/ieo ooieoe?e ca noiaaeueiith oeaeith. Ca aeaieie NRS oeaee iaa?ieia?/iee noaoon iie?iooaaany c 54,6±3,3 aei 79,2±4,5 aae?a (p<0,05) i?e cia/iiio iie?auaii?, a o an??? a?oie - c 51,7±2,9 aei 69,4±3,0 aae?a (p<0,05). Oaeiae ?acoeueoaoe e?eoaaiiy ?noioii ia caeaaeaee a?ae oeio ia?aa?ao ? aeo?aeiiai nooiaiy oyaeeino? caoai?thaaiiy. I?e ioe?ioe? ?ioiiiai noaoono oai?eo ie aeyaeee iiceoeaiee aieea AAI a ii?aeiaii? c aaia?eiii ia iieacieee O-ee?oeiiiai ?ioi?oaoo. Oi/a, caaaeueiee ??aaiue O-e?ioioeeo?a o ieo eieeaaany a iaaeao ii?ie, niinoa??aaeanue ii?iae?caoe?y aeenaaeaino noaiiioeyoe?e, a naia - i?aeaeuoaaany a?aeiiniee ??aaiue Oo (c 21±2 aei 30±4%, p<0,05), a oiio /ene? ?o aaniethoia e?euee?noue (c 390±28 aei 599±32, p<0,05). O oai?eo oe??? i?aea?oie niinoa??aaeanue oaeiae ii?iae?caoe?y a?aeiiniiai ??aiy On (aei 12±1,2%, p<0,05) ? ?o aaniethoiiai /enea (aei 254±15, p<0,001). O oai?eo, ui aeienaeenue c? cia/iei iie?auaiiyi AAI a ii?aeiaii? c aaia?eiii noaa?e?coaaea aeaye? iieacieee aoii?aeueiiai ?ioi?oaoo (Ae), iniaeeai o iaoe??io?a c iaae?aaeaiith aeoeaaoe??th aei e?eoaaiiy. O ieo iie?iooaaeenue oaeiae ?aieia?/i? aeanoeaino? e?ia?, ciaiooaaany ??aaiue o?a?eiiaaio (c 10,76±0,82 a/e aei 6,4±0,7 a/e, p<0,001) oa i?iaeoeo?a eiai aeaa?aaeaoe??, ca?eueooaaeanue o?eaae?noue /ano ?aeaeueoe?o?eaoe?? (c 1,1±0,08 oa. aei 1,5±0,1 oa., p<0,05). A?io?i?/ia ianoaaeaiiy oai?eo, ui e?eoaaeenue AAI a ii?aeiaii? c aaia?eiii, aeyaeei aeayeee iiceoeaiee aieea oa?ai?? ia a?eeiaee iai?i ? aeaoieneeaoe?ei? yeino? iaoiaeo, cie?aia, niinoa??aaeanue oaiaeaioe?y aei ca?eueoaiiy ??aiy caaaeueiiai a?eea (c 74,5±4 aei 78,5±3 a/e, p>0,05), ciaioeany ??aaiue NI (c
0,590±0,1 aei 0,300±0,1 IAe, p<0,05). ?acii c oei, aeyaeaiee ? iaaaaeaiee aoaeo oa?ai?? - c?inoaiiy aeenaeiaoe?iai??. Oaeei /eiii, aeey ioe?iee aoaeoeaiino? canoinoaaiiy AAI a ii?aeiaii? c aaia?eiii, e??i ee?i?/ieo aeaieo, aaaeeeai a?aoiaoaaoe e?eueeino? Oo ? On, Ae, ??aaiue caaaeueiiai a?eea ? eiai o?aeoe?e, NI, eiioeaio?aoe?th ne?iaaoi/iiai o?a?eiiaaio oa iayai?noue i?iaeoeo?a eiai aeaa?aaeaoe??. I?iaaaeai? ee?i?ei-eaai?aoi?i? aeine?aeaeaiiy aeiaaee, ui AAI iiaea aooe canoiniaaia oai?ei ia ?N iacaeaaeii a?ae nooiaiy oyaeeino? ? ia?aa?ao caoai?thaaiiy, aeeth/ath/e ? noaae?th caaino?aiiy. I/aaeaeii, aoaeoeai?noue iaoiaeo i?aeaeuoaaeanue ca ?aooiie ii?aeiaiiy c i?aeoe??iei aaaaeaiiyi aaia?eio a iaeeo aeicao. Eaai?aoi?iei iieacaiiyi aei canoinoaaiiy AAI a ii?aeiaii? c aaia?ei?caoe??th e?ia? ? aeenaaeain noaiiioeyoe?e ee?oeiiiai ?ioi?oaoo c ia?aaaaeiei ciaioaiiyi ??aiy On, ia??cei ae?aaeaiee A-e?ioioeeoic, c?inoaiiy ??aiy o?a?eiiaaio oa ?ioeo iciae eaoaioiiai AeAC-neiae?iio. Aoaeoeai?noue canoinoaaiiy AN a ii?aeiaii? c OOI e?ia? ie aea/eee a 10 oai?eo ia ?N. Iaaaeeea e?euee?noue iaoe??io?a iia’ycaia c? neeaaei?noth oa a?ii?caee?noth iaoiaeeee i?iaaaeaiiy AN. ?acoeueoaoe ee?i?/iiai ianoaaeaiiy iieacaee, ui canoinoaaiiy AN a ii?aeiaii? c OOI e?ia? a eiiieaeniiio e?eoaaii? o?eueee o iaeiiai oai?iai i?eaaei aei cia/iiai iie?auaiiy noaio c a?aeiiaeaiiyi ?ooiaeo ii?ooaiue, ii?iae?caoe?? oiiono i’yc?a, ciaioaiiyi ae?aaeaiino? aoaen??, iie?auaiiyi iaa?ieia?/iiai noaoono ca oeaeith NRS c 56,0 aei 76,0 aae?a. O 5 oai?eo niinoa??aaeinue iii??ia iie?auaiiy, a ua a 4 - e?eoaaiiy i?ieoei aac aoaeoo. Iaa?ieia?/iee noaoon ca oeaeith NRS nooo?ai ia ci?ithaaany o an??? a?oie ? ca?eueooaaany c 48,1±3,0 aei 52,7±1,8 aae?a (p>0,05). Iiceoeaiee ee?i?/iee aoaeo niinoa??aaany o?eueee o oai?eo
?ai?ooth/ei ia?aa?aii o noaae?? caaino?aiiy.

Aiae?c eaai?aoi?ieo iieaciee?a iieacaa, ui AN a ii?aeiaii? c OOI e?ia?
aeinoia??ii cieaeoaaea ia?aiao?e aooi?ioiiiai i?ioeano — aeoeaiaaii?
aoii?aeueii? eaiee: e?euee?noue A-e?ioioeeo?a c 33±2,6% aei 18±1,2%
(p<0,001), Oe?E - c 0,13±0,01 aei 0,10±0,01 (p<0,01). I?e aeei?enoaii? oeueiai iaoiaeo oa?ai?? oaeiae cieaeoaaany ??aaiue O-e?ioioeeo?a (c 48±2,3 aei 38±2,4%, p<0,02) ? ?o aaniethoia e?euee?noue (c 820±51 aei 670±39, p<0,05), oiio i?e ae?aaeai?e aeo?aei?e O-e?ioiiai?? aoaeoeai?noue e?eoaaiiy AN a ii?aeiaii? c OOI e?ia? ciaiooaaeanue. I?e a?io?i?/iiio ianoaaeaii? oai?eo ie aeyaeee oaeiae aeinoia??ia cieaeaiiy ??aiy NI c 0,590±0,090 IAe aei 0,340±0,05 IAe (p<0,05) ? g-aeiaoe?i?a c 19,7±0,78 IAe aei 16,5±0,52 IAe (p<0,01). E??i aieeao oa?ai?? ia iieacieee ee?oeiiiai ?ioi?oaoo, i?ney e?eoaaiiy iaee i?noea ua e oae? iaaaaeai? aoaeoe ye cieaeaiiy ??aiy caaaeueiiai a?eea ? a2-aeiaoe?i?a (p<0,05). E?eoaaiiy nooo?ai ia aieeaaei ia iieacieee eiaaoeia?aie. Oaeei /eiii, aiae?coth/e aeeiai?eo ee?i?ei-eaai?aoi?ieo aeaieo o i?ioean? e?eoaaiiy AN a ii?aeiaii? c OOI e?ia?, ie i?eeoee aei aeniiaeo, ui iieacaiiy aei oeueiai iaoiaeo aeineoue iaiaaeai?: oeae iaoiae oa?ai?? aeioe?eueii canoiniaoaaoe oai?ei ia ?N o noaae?? caaino?aiiy caoai?thaaiiy i?e iaaeinoaoi?e aoaeoeaiino? iaaeeeaiaioicii? oa?ai??, a oaeiae o aeiaaeeao, eiee niinoa??aa?oueny aeoeaaoe?y aoii?aeueii? eaiee ?ioi?oaoo (ca?eueoaiiy e?eueeino? A-e?ioioeeo?a ? Oe?E), O-ee?oeiiee ?ioi?oao ia??cei i?eai?/aiee ? ca?eueoaiee ??aaiue NI. No/anieie iaaeeeaiaioicieie iaoiaeaie e?eoaaiiy ?N ? canoinoaaiiy i?aia?ao?a a?oie ?ioa?oa?ii?a. A aeinooii?e e?oa?aoo?? ua ia aena?oeaiee ?ioiinoeioethth/ee aoaeo canoinoaaiiy a?o/eciyiiai a-2b-?ioa?oa?iio-eaoa?iio i?e e?eoaaii? oai?eo ia ?N o ii??aiyeueiiio aniaeo? c aaceniith oa?ai??th oa iaiaaeeeaiaioicieie iaoiaeaie e?eoaaiiy. ?acoeueoaoe ee?i?/iiai ianoaaeaiiy iieacaee, ui canoinoaaiiy eaoa?iio a eiiieaeniiio e?eoaaii? 20 oai?eo ia ?N o 45% aeiaaee?a i?ecaiaeeoue aei cia/iiai iie?auaiiy ee?i?ei-iaa?ieia?/iiai noaoono oa eaai?aoi?ieo iieaciee?a, ua o 30% niinoa?aaeaiue iaei i?noea iii??ia iie?auaiiy, ? eeoa o 25% aeiaaee?a aoaeoo ia niinoa??aaeinue. Aeiaeaoeiaa aeeth/aiiy a i?ia?aio e?eoaaiiy eaoa?iio aeceaaei iiceoeaiee oa?aiaaoe/iee aoaeo c a?aeiiaeaiiyi iaa?ieia?/ieo ooieoe?e, iniaeeai o oai?eo c ii/aoeiaeie nooiaiyie oyaeeino? ?N ? ?ai?ooth/ei ia?aa?aii caoai?thaaiiy. Iaa?ieia?/iee noaoon ca oeaeith NRS iie?aueany c 52,2±3,4 aei 64,9±2,9 aae?a (p<0,05), o I i?aea?oi? - aei 80,9n3,5 aae?a (p<0,05). Oa?ai?y c aeeth/aiiyi eaoa?iio i?e aoaeoeaiiio e?eoaaii? ni?eyea ca?eueoaiith a?aeiiniiai ai?noo O-e?ioioeeo?a (c 32±2 aei 53±2%, p<0,001) ? i?aeaeuoaaea ?o aaniethoia /enei (c 550±32 aei 670±37, p<0,05), ciaiooaaea aeenaaeain noaiiioeyoe?e. I?e/iio c?ooaiiy iieaciee?a aaniethoii? e?eueeino? noaiiioeyoe?e aoei a?eueoei aeey Oo (p<0,05). ??aaiue O? ca?eueooaaany c 33±2 aei 48±2 (p<0,001). Oaeei /eiii, i?aia?ao eaoa?ii iiaea canoiniaoaaoenue i?e e?eoaaii? oai?eo ?ai?ooth/ei ia?aa?aii ?N, ia ii/aoeiaeo noaae?yo caoai?thaaiiy, ?ioiieia?/i? ii?ooaiiy yeeo i?iyaeythoueny O-e?ioiiai??th c iacia/iei i?eai?/aiiyi O-noi?ani?ii? eaiee ? cieaeaiiyi oaaioeeoa?iiai ?iaeaeno. Ii??aiyeueiee aiae?c ?acoeueoao?a e?eoaaiiy o an?o a?oiao aeyaea, ui iaea?eueo aoaeoeaiei ? canoinoaaiiy a eiiieaeni?e oa?ai?? AAI a ii?aeiaii? c iaeeie aeicaie aaia?eio oa eaoa?iio. Cia/ia aoaeoeai?noue canoinoaaiiy oeeo iaoiae?a iiynith?oueny iiceoeaiei aieeaii ia a?aeiiaeaiiy iaa?ieia?/ieo ooieoe?e oa ?ioiinoeioethth/eie aeanoeainoyie. ?ioiinoeioethth/? aoaeoe AAI, aieiaiei /eiii, noinoaaeenue ii?iae?caoe?? aeenaaeaino noaiiioeyoe?e O-ee?oeiiiai ?ioi?oaoo c ia?aaaaeiei aieeaii ia O-noi?ani?io noaiiioeyoe?th, a eaoa?iio - ia O-oaeia?io noaiiioeyoe?th oa ??aaiue oaaioeeoa?iiai ?iaeaeno. AAI a ii?aeiaii? c iaeeie aeicaie aaia?eio ni?eyea ii?iae?caoe?? aaii?aieia?/ieo ii?ooaiue c e?ea?aeaoe??th iciae AeAC-neiae?iio. I?e e?eoaaii? iaoiaeaie AAI a ii?aeiaii? c aaia?eiii ? eaoa?iiii cia/ia iie?auaiiy niinoa??aaeinue a?aeiia?aeii o 48,8% ? 45% aeiaaee?a, a e?euee?noue iaoe??io?a, aeienaieo aac aoaeoo, a?aeiia?aeii nei?i/oaaeanue aei 19,5% ? 25%. Canoinoaaiiy o?eueee aacenii? oa?ai?? ni?eyei cia/iiio iie?auaiith o 30% niinoa?aaeaiue, a AN a ii?aeiaii? c OOI e?ia? - eeoa a iaeiiai oai?iai (10%). Ii?iae?caoe?y aoii?aeueieo ii?ooaiue i?e canoinoaaii? AN ia ca?eueooaaea ?? oa?aiaaoe/ii? aoaeoeaiino?, iaaooue, aiane?aeie iaaaoeaiiai aieeao oeueiai iaoiaeo ia O-ee?oeiiee ?ioi?oao, yeee ia eiiiainoaaany iaa?oue i?iaaaeaiiyi OOI e?ia?. E?eoaaiiy ?icn?yiiai neea?ico i?iaeiaaeo? caeeoaoenue iaei??th c iaeneeaaei?oeo i?iaeai ee?i?/ii? iaa?ieia??, a aeine?aeaeaiiy, ye? i?iaiaeyoueny a oeueiio iai?yieo, ? iiaeaeueoei, oi/ ? iacia/iei e?ieii aeey ae??oaiiy oe??? i?iaeaie. Aeniiaee 1. ?icn?yiee neea?ic oa?aeoa?eco?oueny aaoa?iaaii?noth iaa?ieia?/ieo ii?ooaiue, ye? oi?iothoue oae? ee?i?/i? oi?ie caoai?thaaiiy: oea?aa?i-ni?iaeueio (63,4%), ni?iaeueio (19,8%) oa oea?aa?aeueio (19,8%), a iaaeao yeeo aeae?eai? oae? aa??aioe ia?aa?ao: ?ai?ooth/i-i?ia?anoth/ee, ia?aeiii- oa aoi?eiii-i?ia?anoth/ee ? aeia?iye?niee. C /anii i?ia?anoaaiiy ?N oi?ia ? oei ia?aa?ao iiaeooue ci?ithaaoenue. 2. Nooi?iue oyaeeino? ?N i?e ??cieo ee?i?/ieo oi?iao ? ??cieo aa??aioao ia?aa?ao caoai?thaaiiy iiaeia ia’?eoeaii ioe?ieoe iaoiaeii iaoaiaoe/ii-noaoenoe/ii? ia?iaee ae?aaeaiino? iaa?ieia?/iiai aeao?oeeoo c aeei?enoaiiyi NRS oeaee; aaeueia ioe?iea iaa?ieia?/ieo ii?ooaiue aea? iiaeeea?noue aecia/eoe a?inioe?aeueiee iioaioe?ae oai?iai, i?iaiicoaaoe ooieoe?iiaeueiee aeo?ae i?ney e?eoaaiiy. 3. Aeine?aeaeaiiy ?ioiiiai i?io?eth, a?eeiaiai iai?io oa ??aiy na?aaei?o iieaeoe (NI) o aca?iica’yceo c oeiii ee?i?/iiai ia?aa?ao ?N ? nooiaiai eiai oyaeeino? aeiiiiaaa? aecia/eoe aino?ioo oa i?ia?aae??ioi?noue aeai??e?i?coth/iai i?ioeano; aeniea ?ioi?iaoeai?noue ?ioii-a?io?i?/ieo aeine?aeaeaiue aeicaiey? ?aeiiaiaeoaaoe ?o ye e?eoa??? aeai?o iaoiae?a oa?ai?? oa ioe?iee ?? aoaeoeaiino?. 4. Aeoeai?noue aeai??e?i?coth/iai i?ioeano oa nooi?iue eiai eiiiainaoe?? o?nii aca?iica’ycai? c ii?ooaiiyi iieaciee?a aaiinoaco, cie?aia, c ?icaeoeii iciae eaoaioiiai AeAC-neiae?iio; ca iayaiino? oeeo ci?i aeioe?eueii aei eiiieaenii? oa?ai?? aeeth/aoe aaia?ei o iaeeo aeicao. 5. Canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? (AAI) a ii?aeiaii? c iaeeie aeicaie aaia?eio i?aeaeuo? aoaeoeai?noue aacenii? oa?ai??; i?e/iio iiceoeaia aeeiai?ea e?eoaaiiy ia caeaaeeoue a?ae oeio ia?aa?ao oa nooiaiy oyaeeino? ?N. Oeae iaoiae oa?ai?? ia o?eueee ca?eueoo? caaaeueio noio aae?a iaa?ieia?/iiai noaoono ca oeaeith NRS, aea e ni?ey? ii?iae?caoe?? aeenaaeaino noaiiioeyoe?e ee?oeiiiai ?ioi?oaoo, aeayeeo ii?ooaiue a?eeiaiai iai?io oa iie?ioo? ?aieia?/i? aeanoeaino? e?ia?. 6. I?iaaaeaiiy aaiini?aoe?? (AN) a ii?aeiaii? c OOI e?ia? i?e eiiieaeniiio e?eoaaii? oai?eo ia ?N ia? aooe aeeoa?aioe?eiaaiei: oaeo oa?ai?th aeioe?eueii i?ecia/aoe oai?ei c ?ai?ooth/ei ia?aa?aii caoai?thaaiiy a noaae?? caaino?aiiy, iniaeeai i?e aeoeaaoe?? aoii?aeueii? eaiee ?ioi?oaoo c iaoith cieaeaiiy eiioeaio?aoe?? Oe?E ? ??aiy NI; o aeiaaeeao i?eai?/aiiy O-ee?oeiii? eaiee ?ioi?oaoo ? iayaiino? iciae eaoaioiiai AeAC-neiae?iio i?ecia/aiiy oeueiai iaoiaeo e?eoaaiiy nooo?ai ia aieeaa? ia a?aeiiaeaiiy iaa?ieia?/ieo ooieoe?e. 7. Aeeth/aiiy eaoa?iio aei i?ia?aie eiiieaenii? oa?ai?? oai?eo ia ?N aeyaeeinue iaea?eueo aoaeoeaiei i?e e?eoaaii? iaoe??io?a c ii/aoeiaeie nooiaiyie oyaeeino? oa ?ai?ooth/ei ia?aa?aii caoai?thaaiiy; i?aia?ao ?aeiiaiaeo?oueny i?ecia/aoe i?e aeyaeaii? O-e?ioiiai?? oa cieaeaii? oaaioeeoa?iiai ?iaeaeno. 8. I?iaaaeai? ee?i?ei-?ioiieia?/i? oa ee?i?ei-a?io?i?/i? ni?anoaaeaiiy aoaeoeaiino? ??cieo iaoiae?a e?eoaaiiy ?N cana?ae/eee aeineoue aenieo oa?aiaaoe/io aoaeoeai?noue AAI a ii?aeiaii? c iaeeie aeicaie aaia?eio; i?ecia/aiiy eaoa?iio aeyaeeinue iaea?eueo aoaeoeaiei i?e e?eoaaii? oai?eo c ii/aoeiaeie noaae?yie caoai?thaaiiy; AN a ii?aeiaii? c OOI e?ia? aei?aaaeaii canoiniaoaaoe i?e e?eoaaii? iaoe??io?a ?c caaino?aiiyi aeai??e?i?coth/iai i?ioeano c aeoeaaoe??th aoii?aeueii? eaiee ?ioi?oaoo oa i?aeaeuaiiyi ??aiy NI. I?aeoe/i? ?aeiiaiaeaoe?? 1. C iaoith i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia ?icn?yiee neea?ic aaaeeeai i?iaiaeeoe iiaia eiiieaenia ee?i?ei-?ioiieia?/ia ? a?io?i?/ia ianoaaeaiiy oai?eo. Aeey oeueiai a i?aeoeeo ?iaioe iaa?ieia?/ieo a?aeae?eaiue iaiao?aeii ai?iaaaeaeoaaoe eiiieaen ee?i?ei-eaai?aoi?ieo aeine?aeaeaiue, yeee aeeth/a? aaeueio ioe?ieo ae?aaeaiino? iaa?ieia?/iiai aeao?oeeoo ca NRS oeaeith, o?aooaaiiy oeio ia?aa?ao oa eiai oace, nooiaiy oyaeeino?, iieaciee?a ?ioiiiai noaoono, eiaaoeia?aie oa a?eeiaiai iai?io, o oiio /ene? ??aaiue na?aaeiueiiieaeoey?ieo iaioeae?a. 2. ?ic?iaeaio iaoiaeeeo AAI a ii?aeiaii? c aaia?ei?caoe??th e?ia? iaiao?aeii oe?iei canoiniaoaaoe a i?aeoeeo e?eoaaiiy oai?eo ia ?N, iacaeaaeii a?ae oeio ia?aa?ao oa nooiaiy oyaeeino? caoai?thaaiiy. Ne?ae a?aoiaoaaoe ?ioiinoeioethth/ee aoaeo iaoiaeo, iiceoeaiee aieea eiai ia ?aieia?/i? aeanoeaino? e?ia? oa aeineoue cia/iee nooi?iue a?aeiiaeaiiy iaa?ieia?/iiai aeao?oeeoo ca oeaeith NRS. 3. Aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy oai?eo ia ?N ia ii/aoeiaeo noaae?yo caoai?thaaiiy i?e ?ai?ooth/iio ia?aa?ao aeioe?eueii canoiniaoaaoe a eiiieaeni?e oa?ai?? i?aia?ao eaoa?ii, yeee aieiae?? ?ioiinoeioethth/eie yeinoyie c ia?aaaaeiei aieeaii ia O-oaeia?io eaieo ?ioi?oaoo ? i?aeaeuo? i?e?iaeio aioe?ioaeoe?eio ?acenoaioi?noue. 4. Iiaeiii i?iaiaeeoenue aeeoa?aioe?eiaaia canoinoaaiiy aaiini?aoe?? a ii?aeiaii? c OOI e?ia?. ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue aeathoue i?aenoaao ?aeiiaiaeoaaoe iaoiae eeoa a noaae?? caaino?aiiy caoai?thaaiiy, iniaeeai i?e aeoea?caoe?? aoii?aeueii? eaiee ?ioi?oaoo oa i?aeaeuaii? ??aiy NI ? aac iayaiino? iciae ae?aaeaii? O-e?ioiiai??. Nienie i?aoeue, iioae?eiaaieo ca oaiith aeena?oaoe?? 1. Eiaenue O.I. E?eoaaiiy aaiini?aoe??th oai?eo ?icn?yiei neea?icii // Oe?. a?niee ineoiiaa?ie.-Oa?e?a, 1997.-O. 5, aei. 2(13).-n. 34-35. 2. Eiaenue O.I., Oi?/ I.I. Aoaeoeai?noue canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? o eiiieaeniiio e?eoaaii? oai?eo ia ?icn?yiee neea?ic // Oe?. a?niee ineoiiaa?ie.-Oa?e?a, 1997.-O. 5, aei. 2(13).-n. 32-34. 3. Eiaenue O.I. Canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? a eiiieaeniiio e?eoaaii? oai?eo ia ?icn?yiee neea?ic // Oe?a?inueeee iaoeiai-iaaee/iee iieiae?aeiee aeo?iae.-1998.-?1.-n. 27-29. 4. Eiaenue O.I. Aoaeoeai?noue canoinoaaiiy eaoa?iio o e?eoaaii? oai?eo ia ?icn?yiee neea?ic // Oa?iaeie. a?niee.-1998.-?4.-n. 54-55. 5. Eiaenue O.I. Aoaeoeai?noue canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? a eiiieaeniiio e?eoaaii? oai?eo ia ?icn?yiee neea?ic // Aeooaeuei? ieoaiiy iaoiaaiaco oa e?eoaaiiy noaeeiieo ? aeai??e?i?coth/eo caoai?thaaiue ia?aiai? nenoaie: Iaoa??aee iaoeiai-i?aeo. eiio. iaa?iiao., Ee?a, 7 /a?aiy 1995 ?.-Ee?a, 1995.-n. 159-160. 6. Eiaenue O.I. Aei ieoaiiy i?i ??aaiue na?aaei?o iieaeoe o oai?eo ia ?icn?yiee neea?ic // Aeooaeuei? ieoaiiy iaoiaaiaco oa e?eoaaiiy noaeeiieo ? aeai??e?i?coth/eo caoai?thaaiue ia?aiai? nenoaie: Iaoa??aee iaoeiai-i?aeo. eiio. iaa?iiao., Ee?a, 7 /a?aiy 1995 ?.-Ee?a, 1995.-n. 142-143. 7. Eiaenue O.I. ??aaiue na?aaei?o iieaeoe o oai?eo ?icn?yieo neea?icii // VIII c’?cae iaa?iiaoieia?a, ineo?ao??a oa ia?eieia?a Oe?a?inueei? ?N?, Oa?e?a, 10-12 aeiaoiy 1990 ?.: Oace aeiiia?aeae.-Oa?e?a, 1990.-n. 231-232. 8. Eiaenue O.I. Aoaeoeai?noue canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? o eiiieaeniiio e?eoaaii? oai?eo ia ?icn?yiee neea?ic // II I?aeia?iaeiee eiia?an nooaeaio?a ? iieiaeeo a/aieo, Oa?iii?eue, 6-8 o?aaiy 1998 ?.: Oace aeiiia?aeae.-Oa?iii?eue, 1998.-n. 9. Kobys T.O. Efficiency of use of Lapheron in treatment of patients with Multiple Sclerosis // 29th Danube Symposium of Neurological Sciences and Continuing Education Dubrovnik, 8-11 October 1997, Crotia: Poster Astracts.-Dubrovnik, 1997.-p. 131. Aiioaoe?y Eiaenue O.I. Aoaeoeai?noue canoinoaaiiy a?ia?aa?e/ii? ieneaaiaoe?? oa aaiini?aoe?? o eiiieaeniiio e?eoaaii? oai?eo ia ?icn?yiee neea?ic. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.15 - ia?aia? oai?iae. Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie, Ee?a, 1999. Aeine?aeaeaia aoaeoeai?noue a?ia?aa?e/ii? ieneaaiaoe?? (AAI) a ii?aeiaii? c i?aeoe??iei aaaaeaiiyi aaia?eio a iaeeo aeicao, aaiini?aoe?? (AN) a ii?aeiaii? c oeueo?ao?ieaoiaei ii?ii?iaiiyi (OOI) e?ia? a eiiieaeniiio e?eoaaii? oai?eo ia ?icn?yiee neea?ic (?N). I?iaaaeaia eiiieaenia ee?i?ei-?ioiieia?/ia oa ee?i?ei-a?io?i?/ia ianoaaeaiiy oai?eo ia ?N i?ney e?eoaaiiy. Aoaeoeai?noue iaoiaeee aea/aia a ii??aiyeueiiio aniaeo? c e?eoaaeueiei aoaeoii eaoa?iio oa aacenii? oa?ai??. Oaeineiiaeaiee aeeoa?aioe?eiaaiee i?aeo?ae aei aeai?o iaoiae?a e?eoaaiiy ?N c o?aooaaiiyi oeio ia?aa?ao, nooiaiy oyaeeino?, noiaaeueii? oeaee (NRS) oa ?ioii-a?io?i?/ieo ii?ooaiue. ?ic?iaeai? i?aeoe/i? ?aeiiaiaeaoe?? ii canoinoaaiith AAI, AN oa eaoa?iio a eiiieaeniiio e?eoaaii? oai?eo ia ?N. Eeth/ia? neiaa: ?icn?yiee neea?ic, ee?i?ei-?ioiieia?/ia oa ee?i?ei-a?io?i?/ia ianoaaeaiiy, aoaeoeai?noue, a?ia?aa?e/ia ieneaaiaoe?y, aaia?ei, aaiini?aoe?y, eaoa?ii. Annotation Kobys T.O. Efficiency of use of hyperbaric oxygenation and hemosorbcy in complex treatment of patients with multiple sclerosis. - Manuscript. Dissertation of candidate of medical sciences on the speciality 14.01.15 - nervous diseases. Kyiv Medical Academy for Post-Graduated Education named after P. Shupyk, Health Ministry of Ukraine, Kyiv, 1999. It has been studied efficiency of hyperbaric oxygenation (HBO) together with heparin hypodermic injection in little doses, of hemosorbcy (HS) together with blood ultraviolet exposing ray irradiation (UVI) in complex treatment of patients with multiple sclerosis (MS). The complex clinical-immunological and clinical-biochemical examination of patients with MS after treatment was performed. Efficiency of the methods has been studied in relative aspect with treatment effect of lapheron and basis therapy. The differentiated approach to a choice of the treatment method of MS has been improved taking into account a type of a current, dangerous degree, hundred mark scale (NRS) and immuno-biochemical violations. The practical recommendations of use of HBO, HS and lapheron in complex treatment of patients with multiple sclerosis have been worked. Key words: multiple sclerosis, clinical-immunological and clinical-biochemical examination, efficiency, hyperbaric oxygenation, heparin, hemosorbcy, lapheron. Aiiioaoeey. Eiaunue O.A. Yooaeoeaiinoue i?eiaiaiey aeia?aa?e/aneie ieneaaiaoeee e aaiini?aoeee a eiiieaeniii ea/aiee aieueiuo ?annayiiui neea?icii. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.15 - ia?aiua aieacie. Eeaaneay iaaeeoeeineay aeaaeaiey iineaaeeieiiiiai ia?aciaaiey ei. I.E. Ooieea IC Oe?aeiu, Eeaa, 1999. I?iaaaeaii eiiieaeniia eeeieei-eiioiieiae/aneia e eeeieei-aeioeie/aneia ianeaaeiaaiea 101 aieueiiai ?annayiiui neea?icii. Onoaiiaeaiu iaeaieaa oa?aeoa?iua aa?eaiou oa/aiey caaieaaaiey a i?aaeaeao iniiaiuo eeeie/aneeo oi?i: oea?aa?i-nieiaeueiie, oea?aa?aeueiie e nieiaeueiie. Iieacaii, /oi oi?ia e oei oa/aiey ?annayiiiai neea?ica i?e aai i?ia?anne?iaaiee iiaoo eciaiyoueny. A aeeiaieea i?iaaaeaia iaoaiaoeei-noaoenoe/aneay ia?aaioea noaiaie au?aaeaiiinoe iaa?ieiae/aneiai aeaoeoeeoa n iiiiuueth noiaaeueiie oeaeu (NRS) i?e ?acee/iuo eeeie/aneeo oi?iao e aa?eaioao aai oa/aiey. O aieueiuo ?N onoaiiaeaiu ia?ooaiey eiioiiiai noaoona, aaeeiaiai iaiaia e iieacaoaeae eiaaoeia?aiiu ai acaeiinayce n oeiii oa/aiey, noaaeeae caaieaaaiey e noaiaiueth oyaeanoe. A noaaeee iaino?aiey caaieaaaiey auyaeai aeenaaeain eiioiieiiiaoaioiuo eeaoie O-eeaoi/iiai caaia, aeoeaaoeey aoii?aeueiiai eiioieoaoa, i?eciaee eaoaioiiai AeAN-neiae?iia e iiauoaiea o?iaiy n?aaeieo iieaeoe, ioia?aaeathuaa iaoaaiee/aneea ia?ooaiey a ieaeeiiaie iaiei/ea e a i?aaiecia a oeaeii. Enneaaeiaaia yooaeoeaiinoue i?eiaiaiey aeia?aa?e/aneie ieneaaiaoeee (AAI) a ni/aoaiee n iiaeeiaeiui aaaaeaieai aaia?eia a iaeuo aeicao, aaiini?aoeee a ni/aoaiee n oeueo?aoeieaoiaui iaeo/aieai (OOI) e?iae, eaoa?iia a eiiieaeniii ea/aiee aieueiuo ?annayiiui neea?icii. I?iaaaeaii eiiieaeniia eeeieei-eiioiieiae/aneia e eeeieei-aeioeie/aneia ianeaaeiaaiea aieueiuo ?N iinea ea/aiey. Yooaeoeaiinoue iaoiaeee eco/aia a n?aaieoaeueiii aniaeoa n ea/aaiui yooaeoii eaoa?iia e iaaeeeaiaioiciie aaceniie oa?aiee. Onoaiiaeaia aeinoaoi/ii aunieay oa?aiaaoe/aneay yooaeoeaiinoue AAI a ni/aoaiee n iaeuie aeicaie aaia?eia ca n/ao oiaiueoaiey noaiaie au?aaeaiiinoe iaa?ieiae/aneiai aeaoeoeeoa ii oeaea NRS, eiioiinoeioee?othueo naienoa n ii?iaeecaoeeae aeenaaeaina iieacaoaeae eeaoi/iiai eiioieoaoa e i?aeiouanoaaiiui aeeyieai ia O-noi?anni?iia caaii. I?e i?eiaiaiee iaoiaea auyaeaii oeo/oaiea ?aieiaee e?iae ca n/ao oiaiueoaiey i?eciaeia eaoaioiiai AeAN-neiae?iia e iieiaeeoaeueiia aeeyiea ia iaeioi?ua iieacaoaee aaeeiaiai iaiaia, a oii /enea ii?iaeecaoeey o?iaiy n?aaeiaiieaeoey?iuo iaioeaeia. Iieacaii, /oi ?acoeueoaou ea/aiey nouanoaaiii ia caaenaee io oeia oa/aiey caaieaaaiey e enoiaeiie noaiaie oyaeanoe. Auyaeaii, /oi i?eiaiaiea eaoa?iia iaeaieaa yooaeoeaii i?e ?aieooe?othuai oa/aiee, ia ?aiieo noaaeeyo caaieaaaiey. Oaeaea onoaiiaeaiu eiioiinoeioee?othuea naienoaa i?aia?aoa, n i?aeiouanoaaiiui aeeyieai ia O-oaeia?iia caaii e oaaioeeoa?iue eiaeaen. ?acoeueoaou i?iaaaeaiiuo enneaaeiaaiee iieacaee iaiaoiaeeiinoue aeeooa?aioee?iaaiiiai i?eiaiaiey AN a ni/aoaiee n OOI e?iae. Onoaiiaeaii, /oi i?eiaiaiea aeaiiiai iaoiaea ii?aaaeaii oieueei i?e iaino?aiee caaieaaaiey n aeoeaecaoeeae aoii?aeueiiai caaia eiioieoaoa e iiauoaieai o?iaiy A-eeioioeeoia e OeEE, a oaeaea i?e oaaee/aiee eiee/anoaa n?aaeiaiieaeoey?iuo iaioeaeia e ionoonoaee au?aaeaiiie O-eeioiiaiee. N?aaieoaeueiue aiaeec ?acoeueoaoia ea/aiey ai anao a?oiiao onoaiiaee aeinoaoi/ii aunieoth yooaeoeaiinoue i?eiaiaiey a eiiieaeniie oa?aiee AAI a ni/aoaiee n iiaeeiaeiui aaaaeaieai aaia?eia a iaeuo aeicao e eaoa?iia. I?e eniieueciaaiee yoeo iaoiaeia a n?aaieoaeueiii aniaeoa n aaceniie iaaeeeaiaioiciie oa?aieae iieacaii oaaee/aiea /enea iaoeeaioia ni cia/eoaeueiui oeo/oaieai ca n/ao nie?auaiey /enea aieueiuo n oia?aiiui oeo/oaieai e auienaiiuo aac yooaeoa. I?iaaaeaiiua eeeieei-eiioiieiae/aneea e eeeieei-aeioeie/aneea niiinoaaeaiey yooaeoeaiinoe ?aciuo iaoiaeia ea/aiey iicaieeee oniaa?oainoaiaaoue aeeooa?aioee?iaaiiue iiaeoiae e auai?o i?ia?aii ea/aiey. ?ac?aaioaiu i?aeoe/aneea ?aeiiaiaeaoeee ii i?eiaiaieth AAI a ni/aoaiee n aaaaeaieai aaia?eia a iaeuo aeicao, AN a ni/aoaiee n OOI e?iae e eaoa?iia a eiiieaeniii ea/aiee aieueiuo ?N. Eeth/aaua neiaa: ?annayiiue neea?ic, eeeieei-eiioiieiae/aneia e eeeieei-aeioeie/aneia ianeaaeiaaiea, yooaeoeaiinoue, aeia?aa?e/aneay ieneaaiaoeey, aaia?ei, aaiini?aoeey, eaoa?ii.

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