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Ефективність специфічної та неспецифічної гіпосенсибілізації при полінозах у дітей: Автореф. дис… канд. мед. наук / Е. Еврипіду, Нац. мед. ун-т ім.

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IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO

?iai? I.I.Aiaiiieueoey

Aa?ei?aeo Ae?aaea

OAeE: 616-056.3-616-053.2-615-373.36

AOAEOEAI?NOUe NIAOeEO?*II? OA IANIAOeEO?*II?

A?IINAINEA?E?CAOe?? I?E IIE?IICAO O Ae?OAE

14.01.10 – iaae?ao??y

AAOI?AOA?AO

Aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

Eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

Aeena?oaoe?eia ?iaioa aeeiiaia a Ee?anuee?e iaaee/i?e aeaaeai??

i?neyaeeieiiii? ina?oe ?iai? I.E.Ooieea IIC Oe?a?ie (i.Ee?a).

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?,

Eaneoey Ieueaa ?ea??ii?aia,

Caa?aeoth/a eaoaae?ith iaae?ao??? ?1
Ee?anueei? iaaee/ii?

Aeaaeai?? i?neyaeeieiiii? ina?oe ?iai?
I.E.Ooieea

IIC Oe?a?ie (i.Ee?a).

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Oyaeea Ieaenaiae?a Aanee?aia,

caa?aeoth/a eaoaae?ith iaae?ao??? ?1
Iaoe?iiaeueiiai

iaaee/iiai oi?aa?neoaoo ?iai?
I.I.Aiaiiieueoey IIC

Oe?a?ie;

Aeieoi? iaaee/ieo iaoe, i?ioani?

Iicaeaanueeee Aiaoie?e Oaiaeiniae/,

?inoeooo iaae?ao???, aeooa?noaa oa
a?iaeieia?? AII

Oe?a?ie, caa?aeoth/ee a?aeae?eii
ioeueiiiieia??.

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC

Oe?a?ie, eaoaae?a oieoaeueii?
iaae?ao??? ?1, i.Aei?i?i-

iao?ianuee.

Caoeno a?aeaoaeaoueny “30” aa?aniy 1999?. ) 10 aiae. Ia can?aeaii?

Niaoe?ae?ciaaii? ?aaee Ae 26.003.02 i?e Iaoe?iiaeueiiio iaaee/iiio
oi?aa?neoao?

?i. I.I.Aiaiiieueoey (252004, i.Ee?a, aoeuea. O.Oaa/aiea, 17, aoaeeoi??y

Oa?aiaaoe/ii? ee?i?ee).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? oi?aa?neoaoo
(252057

I.Ee?a-57, aoe.Ciieia?/ia, 3).

Aaoi?aoa?ao ?ic?neaie “14” o?aaiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

?aaee Ae 26.003.02

Aeieoi? iaaee/ieo iaoe Nae?eae N.A,

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie

E?eoaaiiy aea?a?eiiai ?ei?oo ? ia nueiaiaei? aeooaeueiith i?iaeaiith
iaae?ao???. Aea?a?eiee ?ei?o – iaea?eueo /anoa oi?ia aoii?/ieo
caoai?thaaiue. Eiai iioe?ai?noue o iiioeyoe?? neeaaea? a?ae 5 aei 20% o
??cieo e?a?iao na?oo. (European allergy white paper, 1997). Ca inoaii?
?iee ia a?eueo ?aii?e a?e ci?noeany i?e caoai?thaaiino? iie?iicii, yeee
a Aiae?? i?eiaaea? ia 5-15 ?ie?a, o Aeai?? ia- 10-19 ?ie?a. Ca aeaieie
?a?iiaenueei? i?ia?aie ISAAC, caoai?thaai?noue naciiiei aea?a?eiei
?ei?oii ca inoaii? aeanyoee?ooy c?inea a 2-3 ?ace. A??ia?aeiei
iiyniaiiyi aeaiiai oaeoo aaaaeathoue caa?oaeiaiiy iaaeieeoiueiai
na?aaeiaeua.

Iayai?noue aea?a?eiiai ?ei?oo cia/ii iia??oo? ye?noue aeeooy oai?iai.
Aaaaeathoue, ui ye?noue aeeooy aeeoeie c oyaeeei ia?aa?aii naciiiiai
aea?a?eiiai ?ei?oo (NA?) a?aeiia?aea? yeino? aeeooy oai?iai
a?iio?aeueiith anoiith (Smith, 1983). Oiio ?ic?iaea aoaeoeaii?
eiiieaenii? oa?ai?? aea?a?eiiai ?ei?oo yaey? niaith aeooaeueio i?iaeaio,
ui ia? ia o?eueee iaaee/ia, aea e nioe?aeueia cia/aiiy.

Aeooaeuei?noue aeaii? i?iaeaie c?inoa? a ca’yceo c aoaii?noth ?icaeoeo
nainea?e?caoe?? o ae?oae, a oaeiae iiaeeea?noth o?ainoi?iaoe?? “iaeeo
?ani??aoi?ieo aea?aic?a” o a?iio?aeueio anoio. ?nio? aeoiea, ui
aoaeoeaia iaaeeeaiaioicia oa?ai?y iie?iico iiaea caiia?aoe oi?ioaaiith
a?iio?aeueii? anoie ye iaea?eueo oyaeei? oi?ie ?ani??aoi?iiai aea?aico
(Ii?ioeia TH.A.,1981, Aaeeai?oaa I.Ae. ? ni?aaao. 1985).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?eia ?iaioa aeeiiaia a ?aieao iniiaieo iaoeiaeo
aeine?aeaeaiue eaoaae?e iaae?ao??? ?1 EIAII. “Ee?i?ei-iaoiaaiaoe/i?
aa??aioe ? aoaeoeai?noue oa?ai?? ?ani??aoi?ieo aea?aic?a o ae?oae o
a?eiaiio aniaeo?”, ? aea?aeaaii? ?a?no?aoe??: E A 01013633?.

Iaoa ?iaioe: oaeineiiaeaiiy iaoiae?a aoaeoeaiiai eiiieaeniiai e?eoaaiiy
naciiiiai aea?a?eiiai ?ei?oo o ae?oae c aeei?enoaiiyi ia?aaenaciiii?
niaoeeo?/ii? ?ioiioa?ai?? ? iaaeeeaiaioicieo cania?a o ia??iae?
caaino?aiiy.

Ie?ai? oe?eueia? caaaeaiiy:

· Aea/eoe ee?i?/i? iniaeeaino? naciiiiai aea?a?eiiai ?ei?oo o ae?oae
?aa?iio.

· Ioe?ieoe aoaeoeai?noue ? aaciaeo ei?aoaaeeia – aioea?noai?iiiai
i?aia?aoo iiaiai iieie?iiy – o oa?ai?? ae?oae c naciiiei aea?a?eiei
?ei?oii.

· Iaa?oiooaaoe iieacaiiy aei i?ecia/aiiy acaeanoeia a?ae?ioei?eaea –
iacaeueiiai ni?ay oa aecia/eoe eiai i?noea a oa?aiaaoe/iiio aeai?eoi?
ae?oae c NA?.

· Ioe?ieoe aoaeoeai?noue ? aaciaeo niaoeeo?/ii? ?ioiioa?ai?? NA? o
ae?oae.

· ?ic?iaeoe oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai ?ei?oo o ae?oae
c a?aooaaiiyi aaaeeino? ia?aa?ao caoai?thaaiiy.

Iaoeiaa iiaecia ?iaioe

Aeiaaaeaii aoaeoeai?noue ? a?aeiinio aaciaeo niaoeeo?/ii? ?ioiioa?ai??
ieeeiaeie aea?aaiaie a?o/eciyiiai ae?iaieoeoaa o ae?oae c NA?, aecia/aii
?? i?noea a eiiieaeniiio e?eoaaii? ? i?io?eaeoeoe? caaino?aiue NA?.

Aea/aii ee?i?/i? iniaeeaino? naciiiiai aea?a?eiiai ?ei?oo a
?aa?ii?.(Ee?a ? Ee?anueea iaeanoue).

Aia?oa a Oe?a?i? aecia/aii ?acoeueoaoeai?noue canoinoaaiiy
aioea?noai?iieo i?aia?ao?a iiaiai iieie?iiy – ei?aoaaeeia ? acaeanoeia
a?ae?ioei?eaea o eiiieaeni?e oa?ai?? ae?oae c NA?.Aia?oa canoiniaaii
i?eoeioiao??th aeey aea/aiiy aioo??oiueiiacaeueiiai iii?o o ae?oae.
Cai?iiiiiaaii oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai ?ei?oo a
caeaaeiino? a?ae aaaeeino? ia?aa?ao caoai?thaaiiy.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a.

?ic?iaeaii eiiieaeniee oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai
?ei?oo o ae?oae c aeei?enoaiiyi ia?aaenaciiii? niaoeeo?/ii?
?ioiioa?ai?? oa aoaiiei canoinoaaiiyi iaaeeeaiaio?a a caeaaeiino? a?ae
aaaeeino? caoai?thaaiiy, ui caaacia/o? aenieo aoaeoeai?noue (86,2%)
e?eoaaiiy. O 36,2% ae?oae ?c NA? i?ney i?iaaaeaiiy N?O caaino?aiue ia
niinoa??aaeiny. O 69,8% ae?oae o ia??iae? caaino?aiiy aaeaeiny aeinyaoe
iiceoeaieo ?acoeueoao?a, aeei?enoiaoth/e aioea?noai?ii? i?aia?aoe iiaiai
iieie?iiy–ei?aoaaeei ? acaeanoeia a?ae?ioei?eae i?noeaai ? ia?i?aeueii o
aeaeyae? iiiioa?ai?? aai a niieo/aii?.

O iaoe??io?a c neeueii ae?aaeaieie aai ??ciiiai?oieie neiioiiaie
iaiao?aeia eiia?iiaaia oa?ai?y, ui aeeth/a? ianoa?i?aei? (e?iiiie) ?
noa?i?aei? oii?eaeuei? caniae.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo.

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a i?aeoeeo OAeNE
“Ioiaaeeo”,i?nueeith aeeoy/ith ee?i?/iith e?ea?iath ? 2 i.Ee?aa,
iaeaniith aeeoy/ith ee?i?/iith e?ea?iath i.Iieoaae, i?i ui na?ae/aoue
a?aeiia?aei? aeoe ai?iaaaeaeaiiy.

Iaoa??aee aeena?oaoe?? aeeeaaeathoueny o iaa/aeueiiio i?ioean? ia
eaoaae?? iaae?ao??? ? 1 Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe.

Iniaenoee aianie aeena?oaioa.

Aaoi? naiino?eii ?ic?iaeea i?ia?aio ? iaoiaeieia?th aeine?aeaeaiiy,
i?iaiaeeea ianoaaeaiiy ? e?eoaaiiy oai?eo. ?acoeueoaoe aeine?aeaeaiiy
io?eiai? iniaenoi aeena?oaioii, naiino?eii i?iaaaeaii aiae?c ia?aeiiiai
iaoa??aeo, noi?iiaai? aieiai? iieiaeaiiy oa aeniiaee ?iaioe.

Ai?iaaoe?y oa iioae?eiaaii?noue ?acoeueoao?a ?iaioe

Iniiai? iieiaeaiiy ?iaioe aeeeaaeai? ia XVI-XVII ui??/ieo eiia?anao
?a?iiaenueei? Anioe?aoe?? Aea?aieia?a oa ?ioiieia?a (1997, 1998), ia VII
oa VIII iaoe?iiaeueieo eiia?anao c oai?ia i?aai?a aeeoaiiy (Iineaa
1997,1998), ), ?-io iaoe?iiaeueiiio eiia?an? ii ee?i?/i?e ?ioiieia?? oa
aea?aieia?? (Aeoooa, 1998), ia I-io i?aeia?iaeiiio iaaee/iiio eiia?an?
nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue,1997), ia iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeuei?noue ieoaiue i?e?io??o?a?? aooa ? caoai?thaaiue
aa?oi?o aeeoaeueieo oeyo?a” (Ee?a 1997), OO eiioa?aioe?? iieiaeeo a/aieo
EIAII (Ee?a, 1997).

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 11 iaoeiaeo i?aoeue, a oiio
/ene? /ioe?e iaoeia? noaoo? o aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie.

Ianya ? no?oeoo?a aeena?oaoe??: aeena?oaoe?y aeeeaaeaia ia 131
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, /ioe?ueio ?icae?e?a aeanieo aeine?aeaeaiue, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, iaeyaeo e?oa?aoo?e, ui aeeth/a? 243
aeaea?aea. ?iaioa ?ethno?iaaia 17 oaaeeoeyie ? 13 iaethieaie.

CI?NO ?IAIOE

Ia’?eo ? iaoiaee aeine?aeaeaiiy:

Aeey ae??oaiiy iinoaaeaieo caaaeaiue i?ae niinoa?aaeaiiyi ciaoiaeeeiny
136 ae?oae c naciiiei aea?a?eiei ?ei?oii o a?oe? a?ae 5 aei 14 ?ie?a.
Eiiieaenia ianoaaeaiiy ae?oae i?iaaaeaia a 1993-1998 ??. ia aac?
i?nueei? aeeoy/i? niaoe?ae?ciaaii? e?ea?i? ?14 i. Ee?aa. (c 1997 ?.
Oe?a?inueea aeeoy/a niaoe?ae?ciaaia e?ea?iy “Ioiaoaeeo”),
eiinoeueoaoeaii? iie?ee?i?ee ? eiia?oe?eiiai ia’?aeiaiiy “Vitanal”.

Niaoe?aeuei? iaoiaee aea?aieia?/iiai oa ?ioiieia?/iiai aeine?aeaeaiiy
aeeth/aee oe??i? nea?eo?eaoe?ei? oanoe a?ia?/ooeeaino? iaaaeiiai oeio
ca caaaeueiii?eeiyoith iaoiaeeeith (A.Ae. Aaei ,1976, Nieieiaa O.N. ?
ni?aaao., 1989). Ei?enooaaeenue aiaeii-nieueiaeie ieeeiaeie aea?aaiaie
a?o/eciyiiai ae?iaieoeoaa o 85 ae?oae ? eaiaaenueeiai ae?iaieoeoaa – o
37 ae?oae. A?o/eciyiee ae?iaiee – iaea i?aei?e?inoai “?ioiieia”, i.
A?iieoey, eaiaaenueeee -Ben Card Allergy laboratory Antario (Tirosin
absorbit tree vaxin, Tirosin absorbit grass vaxin, Suspal allergenic
extract presesoneus).

E?euee?nio ioe?ieo O- ? A-nenoai ?ioi?oaoo i?iaiaeeee ca aeiiiiiaith
?aaeoe?? ?icaoeiooai?aiiy (A-?OE ca Jondel e. a. , 1972, EAC-POK ca
Dolen, 1970).

Ca iaoiaeeeith Zimatibul a.a (1978) aecia/aee e?euee?noue
oaio?e?i/ooeeaeo ? oaio?e?i?acenoaioieo ee?oei. Eiioeaio?aoe?th
ne?iaaoeiaeo ?ioiiaeiaoe?i?a G, A, M aecia/aee iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? ii Iancini e. a. (1965).

Aecia/aiiy eiioeaio?aoe?? ne?iaaoeiaiai JgA i?iaiaeeee ca aeiiiiiaith
aiae?caoi?a Ioeueoeneai LP-400 (O?aioe?y, Neiao? Ae?aaiinoeea Ianoa?)
iaoiaeii ?ioiioa?iaioiiai aiae?co (?OA).

Aeey aei??o aioo??oiueiiacaeueiiai oeneo aeei?enoiaoaaee iaoiae
i?eoeioiao??? (Rosana Gianico, Carlos A. A. Oliviera 1996, S. B.
Phangoo, R. A Watson and N. B Pride 1996). Iaoiaeeea ? aeoaea i?inoith,
c?o/iith aeey aeeoy/iai a?eo ? aeei?enoiao?oueny aia?oa ia Oe?a?i?.

Aeey i?ae?aooieo aiceiio?e?a o nae?ao? aeei?enoiaoaaee oeeoieia?/iee
iaoiae aeine?aeaeaiiy iiniaiai nae?aoo .

Aecia/aiiy ooieoe?? ciai?oiueiai aeeoaiiy (OAAe) i?iaiaeeee ia aia?ao?
(spirometr Masterscope, Master Labpro, Medizintechnik mit system Jaeger
TOENNIES). Aoee ianoaaeai? 87 ae?oae. O ae?oae c eaaeith ? na?aaeiueith
aaaee?noth iie?iico OAAe aoea a iaaeao ii?ie. O 16 (59,2%) ?c 27 ae?oae
?c aaaeeith oi?iith NA? i?io?aei?noue a?iio?a aoea cieaeaia.

Noaoenoe/ia ia?iaea ?acoeueoao?a, io?eiaieo i?e i?iaaaeaii?
aeine?aeaeaiiy, cae?enithaaeany iaoiaeaie aa??aoe?eii? noaoenoeee c
?ic?aooieii na?aaei?o a?eoiaoe/ieo cia/aiue (I) ? /anoioii?
oa?aeoa?enoeee ?iciiae?e?a aeine?aeaeoaaieo ia?aiao??a (?).
I?iaiaeeeanue ioe?iea aeinoia??iino? io?eiaieo iieaciee?a ? ?o
?icoiaeaeaiue oeyoii ia/eneaiiy na?aaei?o iioeaie iio?aeieo aaee/ei (m)
? e?eoa??th Nothaeaioa (t-?iciiae?ee). I?i?iaeueiee ??aaiue cia/eiino?
?acoeueoao?a neeaaeaa 95% (?0,05p0,05p0,05 A?ia?a-i?y

Iini-aeioee223

13,610

45,59

40,99

40,98

36,45

22,7P0,05P

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