IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO

?iai? I.I.Aiaiiieueoey

Aa?ei?aeo Ae?aaea

OAeE: 616-056.3-616-053.2-615-373.36

AOAEOEAI?NOUe NIAOeEO?*II? OA IANIAOeEO?*II?

A?IINAINEA?E?CAOe?? I?E IIE?IICAO O Ae?OAE

14.01.10 – iaae?ao??y

AAOI?AOA?AO

Aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

Eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

Aeena?oaoe?eia ?iaioa aeeiiaia a Ee?anuee?e iaaee/i?e aeaaeai??

i?neyaeeieiiii? ina?oe ?iai? I.E.Ooieea IIC Oe?a?ie (i.Ee?a).

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?,

Eaneoey Ieueaa ?ea??ii?aia,

Caa?aeoth/a eaoaae?ith iaae?ao??? ?1
Ee?anueei? iaaee/ii?

Aeaaeai?? i?neyaeeieiiii? ina?oe ?iai?
I.E.Ooieea

IIC Oe?a?ie (i.Ee?a).

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Oyaeea Ieaenaiae?a Aanee?aia,

caa?aeoth/a eaoaae?ith iaae?ao??? ?1
Iaoe?iiaeueiiai

iaaee/iiai oi?aa?neoaoo ?iai?
I.I.Aiaiiieueoey IIC

Oe?a?ie;

Aeieoi? iaaee/ieo iaoe, i?ioani?

Iicaeaanueeee Aiaoie?e Oaiaeiniae/,

?inoeooo iaae?ao???, aeooa?noaa oa
a?iaeieia?? AII

Oe?a?ie, caa?aeoth/ee a?aeae?eii
ioeueiiiieia??.

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC

Oe?a?ie, eaoaae?a oieoaeueii?
iaae?ao??? ?1, i.Aei?i?i-

iao?ianuee.

Caoeno a?aeaoaeaoueny “30” aa?aniy 1999?. ) 10 aiae. Ia can?aeaii?

Niaoe?ae?ciaaii? ?aaee Ae 26.003.02 i?e Iaoe?iiaeueiiio iaaee/iiio
oi?aa?neoao?

?i. I.I.Aiaiiieueoey (252004, i.Ee?a, aoeuea. O.Oaa/aiea, 17, aoaeeoi??y

Oa?aiaaoe/ii? ee?i?ee).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? oi?aa?neoaoo
(252057

I.Ee?a-57, aoe.Ciieia?/ia, 3).

Aaoi?aoa?ao ?ic?neaie “14” o?aaiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

?aaee Ae 26.003.02

Aeieoi? iaaee/ieo iaoe Nae?eae N.A,

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie

E?eoaaiiy aea?a?eiiai ?ei?oo ? ia nueiaiaei? aeooaeueiith i?iaeaiith
iaae?ao???. Aea?a?eiee ?ei?o — iaea?eueo /anoa oi?ia aoii?/ieo
caoai?thaaiue. Eiai iioe?ai?noue o iiioeyoe?? neeaaea? a?ae 5 aei 20% o
??cieo e?a?iao na?oo. (European allergy white paper, 1997). Ca inoaii?
?iee ia a?eueo ?aii?e a?e ci?noeany i?e caoai?thaaiino? iie?iicii, yeee
a Aiae?? i?eiaaea? ia 5-15 ?ie?a, o Aeai?? ia- 10-19 ?ie?a. Ca aeaieie
?a?iiaenueei? i?ia?aie ISAAC, caoai?thaai?noue naciiiei aea?a?eiei
?ei?oii ca inoaii? aeanyoee?ooy c?inea a 2-3 ?ace. A??ia?aeiei
iiyniaiiyi aeaiiai oaeoo aaaaeathoue caa?oaeiaiiy iaaeieeoiueiai
na?aaeiaeua.

Iayai?noue aea?a?eiiai ?ei?oo cia/ii iia??oo? ye?noue aeeooy oai?iai.
Aaaaeathoue, ui ye?noue aeeooy aeeoeie c oyaeeei ia?aa?aii naciiiiai
aea?a?eiiai ?ei?oo (NA?) a?aeiia?aea? yeino? aeeooy oai?iai
a?iio?aeueiith anoiith (Smith, 1983). Oiio ?ic?iaea aoaeoeaii?
eiiieaenii? oa?ai?? aea?a?eiiai ?ei?oo yaey? niaith aeooaeueio i?iaeaio,
ui ia? ia o?eueee iaaee/ia, aea e nioe?aeueia cia/aiiy.

Aeooaeuei?noue aeaii? i?iaeaie c?inoa? a ca’yceo c aoaii?noth ?icaeoeo
nainea?e?caoe?? o ae?oae, a oaeiae iiaeeea?noth o?ainoi?iaoe?? “iaeeo
?ani??aoi?ieo aea?aic?a” o a?iio?aeueio anoio. ?nio? aeoiea, ui
aoaeoeaia iaaeeeaiaioicia oa?ai?y iie?iico iiaea caiia?aoe oi?ioaaiith
a?iio?aeueii? anoie ye iaea?eueo oyaeei? oi?ie ?ani??aoi?iiai aea?aico
(Ii?ioeia TH.A.,1981, Aaeeai?oaa I.Ae. ? ni?aaao. 1985).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.

Aeena?oaoe?eia ?iaioa aeeiiaia a ?aieao iniiaieo iaoeiaeo
aeine?aeaeaiue eaoaae?e iaae?ao??? ?1 EIAII. “Ee?i?ei-iaoiaaiaoe/i?
aa??aioe ? aoaeoeai?noue oa?ai?? ?ani??aoi?ieo aea?aic?a o ae?oae o
a?eiaiio aniaeo?”, ? aea?aeaaii? ?a?no?aoe??: E A 01013633?.

Iaoa ?iaioe: oaeineiiaeaiiy iaoiae?a aoaeoeaiiai eiiieaeniiai e?eoaaiiy
naciiiiai aea?a?eiiai ?ei?oo o ae?oae c aeei?enoaiiyi ia?aaenaciiii?
niaoeeo?/ii? ?ioiioa?ai?? ? iaaeeeaiaioicieo cania?a o ia??iae?
caaino?aiiy.

Ie?ai? oe?eueia? caaaeaiiy:

· Aea/eoe ee?i?/i? iniaeeaino? naciiiiai aea?a?eiiai ?ei?oo o ae?oae
?aa?iio.

· Ioe?ieoe aoaeoeai?noue ? aaciaeo ei?aoaaeeia — aioea?noai?iiiai
i?aia?aoo iiaiai iieie?iiy — o oa?ai?? ae?oae c naciiiei aea?a?eiei
?ei?oii.

· Iaa?oiooaaoe iieacaiiy aei i?ecia/aiiy acaeanoeia a?ae?ioei?eaea —
iacaeueiiai ni?ay oa aecia/eoe eiai i?noea a oa?aiaaoe/iiio aeai?eoi?
ae?oae c NA?.

· Ioe?ieoe aoaeoeai?noue ? aaciaeo niaoeeo?/ii? ?ioiioa?ai?? NA? o
ae?oae.

· ?ic?iaeoe oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai ?ei?oo o ae?oae
c a?aooaaiiyi aaaeeino? ia?aa?ao caoai?thaaiiy.

Iaoeiaa iiaecia ?iaioe

Aeiaaaeaii aoaeoeai?noue ? a?aeiinio aaciaeo niaoeeo?/ii? ?ioiioa?ai??
ieeeiaeie aea?aaiaie a?o/eciyiiai ae?iaieoeoaa o ae?oae c NA?, aecia/aii
?? i?noea a eiiieaeniiio e?eoaaii? ? i?io?eaeoeoe? caaino?aiue NA?.

Aea/aii ee?i?/i? iniaeeaino? naciiiiai aea?a?eiiai ?ei?oo a
?aa?ii?.(Ee?a ? Ee?anueea iaeanoue).

Aia?oa a Oe?a?i? aecia/aii ?acoeueoaoeai?noue canoinoaaiiy
aioea?noai?iieo i?aia?ao?a iiaiai iieie?iiy — ei?aoaaeeia ? acaeanoeia
a?ae?ioei?eaea o eiiieaeni?e oa?ai?? ae?oae c NA?.Aia?oa canoiniaaii
i?eoeioiao??th aeey aea/aiiy aioo??oiueiiacaeueiiai iii?o o ae?oae.
Cai?iiiiiaaii oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai ?ei?oo a
caeaaeiino? a?ae aaaeeino? ia?aa?ao caoai?thaaiiy.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a.

?ic?iaeaii eiiieaeniee oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai
?ei?oo o ae?oae c aeei?enoaiiyi ia?aaenaciiii? niaoeeo?/ii?
?ioiioa?ai?? oa aoaiiei canoinoaaiiyi iaaeeeaiaio?a a caeaaeiino? a?ae
aaaeeino? caoai?thaaiiy, ui caaacia/o? aenieo aoaeoeai?noue (86,2%)
e?eoaaiiy. O 36,2% ae?oae ?c NA? i?ney i?iaaaeaiiy N?O caaino?aiue ia
niinoa??aaeiny. O 69,8% ae?oae o ia??iae? caaino?aiiy aaeaeiny aeinyaoe
iiceoeaieo ?acoeueoao?a, aeei?enoiaoth/e aioea?noai?ii? i?aia?aoe iiaiai
iieie?iiy–ei?aoaaeei ? acaeanoeia a?ae?ioei?eae i?noeaai ? ia?i?aeueii o
aeaeyae? iiiioa?ai?? aai a niieo/aii?.

O iaoe??io?a c neeueii ae?aaeaieie aai ??ciiiai?oieie neiioiiaie
iaiao?aeia eiia?iiaaia oa?ai?y, ui aeeth/a? ianoa?i?aei? (e?iiiie) ?
noa?i?aei? oii?eaeuei? caniae.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo.

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a i?aeoeeo OAeNE
“Ioiaaeeo”,i?nueeith aeeoy/ith ee?i?/iith e?ea?iath ? 2 i.Ee?aa,
iaeaniith aeeoy/ith ee?i?/iith e?ea?iath i.Iieoaae, i?i ui na?ae/aoue
a?aeiia?aei? aeoe ai?iaaaeaeaiiy.

Iaoa??aee aeena?oaoe?? aeeeaaeathoueny o iaa/aeueiiio i?ioean? ia
eaoaae?? iaae?ao??? ? 1 Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe.

Iniaenoee aianie aeena?oaioa.

Aaoi? naiino?eii ?ic?iaeea i?ia?aio ? iaoiaeieia?th aeine?aeaeaiiy,
i?iaiaeeea ianoaaeaiiy ? e?eoaaiiy oai?eo. ?acoeueoaoe aeine?aeaeaiiy
io?eiai? iniaenoi aeena?oaioii, naiino?eii i?iaaaeaii aiae?c ia?aeiiiai
iaoa??aeo, noi?iiaai? aieiai? iieiaeaiiy oa aeniiaee ?iaioe.

Ai?iaaoe?y oa iioae?eiaaii?noue ?acoeueoao?a ?iaioe

Iniiai? iieiaeaiiy ?iaioe aeeeaaeai? ia XVI-XVII ui??/ieo eiia?anao
?a?iiaenueei? Anioe?aoe?? Aea?aieia?a oa ?ioiieia?a (1997, 1998), ia VII
oa VIII iaoe?iiaeueieo eiia?anao c oai?ia i?aai?a aeeoaiiy (Iineaa
1997,1998), ), ?-io iaoe?iiaeueiiio eiia?an? ii ee?i?/i?e ?ioiieia?? oa
aea?aieia?? (Aeoooa, 1998), ia I-io i?aeia?iaeiiio iaaee/iiio eiia?an?
nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue,1997), ia iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeuei?noue ieoaiue i?e?io??o?a?? aooa ? caoai?thaaiue
aa?oi?o aeeoaeueieo oeyo?a” (Ee?a 1997), OO eiioa?aioe?? iieiaeeo a/aieo
EIAII (Ee?a, 1997).

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 11 iaoeiaeo i?aoeue, a oiio
/ene? /ioe?e iaoeia? noaoo? o aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie.

Ianya ? no?oeoo?a aeena?oaoe??: aeena?oaoe?y aeeeaaeaia ia 131
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e, /ioe?ueio ?icae?e?a aeanieo aeine?aeaeaiue, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e, iaeyaeo e?oa?aoo?e, ui aeeth/a? 243
aeaea?aea. ?iaioa ?ethno?iaaia 17 oaaeeoeyie ? 13 iaethieaie.

CI?NO ?IAIOE

Ia’?eo ? iaoiaee aeine?aeaeaiiy:

Aeey ae??oaiiy iinoaaeaieo caaaeaiue i?ae niinoa?aaeaiiyi ciaoiaeeeiny
136 ae?oae c naciiiei aea?a?eiei ?ei?oii o a?oe? a?ae 5 aei 14 ?ie?a.
Eiiieaenia ianoaaeaiiy ae?oae i?iaaaeaia a 1993-1998 ??. ia aac?
i?nueei? aeeoy/i? niaoe?ae?ciaaii? e?ea?i? ?14 i. Ee?aa. (c 1997 ?.
Oe?a?inueea aeeoy/a niaoe?ae?ciaaia e?ea?iy “Ioiaoaeeo”),
eiinoeueoaoeaii? iie?ee?i?ee ? eiia?oe?eiiai ia’?aeiaiiy “Vitanal”.

Niaoe?aeuei? iaoiaee aea?aieia?/iiai oa ?ioiieia?/iiai aeine?aeaeaiiy
aeeth/aee oe??i? nea?eo?eaoe?ei? oanoe a?ia?/ooeeaino? iaaaeiiai oeio
ca caaaeueiii?eeiyoith iaoiaeeeith (A.Ae. Aaei ,1976, Nieieiaa O.N. ?
ni?aaao., 1989). Ei?enooaaeenue aiaeii-nieueiaeie ieeeiaeie aea?aaiaie
a?o/eciyiiai ae?iaieoeoaa o 85 ae?oae ? eaiaaenueeiai ae?iaieoeoaa — o
37 ae?oae. A?o/eciyiee ae?iaiee — iaea i?aei?e?inoai “?ioiieia”, i.
A?iieoey, eaiaaenueeee -Ben Card Allergy laboratory Antario (Tirosin
absorbit tree vaxin, Tirosin absorbit grass vaxin, Suspal allergenic
extract presesoneus).

E?euee?nio ioe?ieo O- ? A-nenoai ?ioi?oaoo i?iaiaeeee ca aeiiiiiaith
?aaeoe?? ?icaoeiooai?aiiy (A-?OE ca Jondel e. a. , 1972, EAC-POK ca
Dolen, 1970).

Ca iaoiaeeeith Zimatibul a.a (1978) aecia/aee e?euee?noue
oaio?e?i/ooeeaeo ? oaio?e?i?acenoaioieo ee?oei. Eiioeaio?aoe?th
ne?iaaoeiaeo ?ioiiaeiaoe?i?a G, A, M aecia/aee iaoiaeii ?aae?aeueii?
?ioiiaeeooc?? ii Iancini e. a. (1965).

Aecia/aiiy eiioeaio?aoe?? ne?iaaoeiaiai JgA i?iaiaeeee ca aeiiiiiaith
aiae?caoi?a Ioeueoeneai LP-400 (O?aioe?y, Neiao? Ae?aaiinoeea Ianoa?)
iaoiaeii ?ioiioa?iaioiiai aiae?co (?OA).

Aeey aei??o aioo??oiueiiacaeueiiai oeneo aeei?enoiaoaaee iaoiae
i?eoeioiao??? (Rosana Gianico, Carlos A. A. Oliviera 1996, S. B.
Phangoo, R. A Watson and N. B Pride 1996). Iaoiaeeea ? aeoaea i?inoith,
c?o/iith aeey aeeoy/iai a?eo ? aeei?enoiao?oueny aia?oa ia Oe?a?i?.

Aeey i?ae?aooieo aiceiio?e?a o nae?ao? aeei?enoiaoaaee oeeoieia?/iee
iaoiae aeine?aeaeaiiy iiniaiai nae?aoo .

Aecia/aiiy ooieoe?? ciai?oiueiai aeeoaiiy (OAAe) i?iaiaeeee ia aia?ao?
(spirometr Masterscope, Master Labpro, Medizintechnik mit system Jaeger
TOENNIES). Aoee ianoaaeai? 87 ae?oae. O ae?oae c eaaeith ? na?aaeiueith
aaaee?noth iie?iico OAAe aoea a iaaeao ii?ie. O 16 (59,2%) ?c 27 ae?oae
?c aaaeeith oi?iith NA? i?io?aei?noue a?iio?a aoea cieaeaia.

Noaoenoe/ia ia?iaea ?acoeueoao?a, io?eiaieo i?e i?iaaaeaii?
aeine?aeaeaiiy, cae?enithaaeany iaoiaeaie aa??aoe?eii? noaoenoeee c
?ic?aooieii na?aaei?o a?eoiaoe/ieo cia/aiue (I) ? /anoioii?
oa?aeoa?enoeee ?iciiae?e?a aeine?aeaeoaaieo ia?aiao??a (?).
I?iaiaeeeanue ioe?iea aeinoia??iino? io?eiaieo iieaciee?a ? ?o
?icoiaeaeaiue oeyoii ia/eneaiiy na?aaei?o iioeaie iio?aeieo aaee/ei (m)
? e?eoa??th Nothaeaioa (t-?iciiae?ee). I?i?iaeueiee ??aaiue cia/eiino?
?acoeueoao?a neeaaeaa 95% (?<0,05) (Ia?eia A.I. Iieyeia E.A., 1974). Ia?iaea ?acoeueoao?a i?iaaaeaia c aeei?enoaiiyi iaeao?a noaoenoe/ieo i?ia?ai Statistica 5.0, SPSS 7.5. ?acoeueoaoe ianoaaeaiiy ? ?o iaaiai?aiiy: I?iaaaeaii eiiieaenia ianoaaeaiiy 136 ae?oae c aea?a?eiei ?ei?oii o a?oe? a?ae 5 aei 14 ?ie?a. Ianoaaeai? ae?oe ?iciiae?eai? ia i?aea?oie a caeaaeiino? a?ae i?iaaaeaiiai e?eoaaiiy: 47 ae?oyi i?iaiaeeeany niaoeeo?/ia ?ioiioa?ai?y, i?ae /an naciiiiai caaino?aiiy, 29 ae?oae e?eoaaeeny o?eueee iacaeueiei ni?a?i acaeanoeia a?ae?ioei?eaea , 26 ae?oae iaea?aeoaaee ia?i?aeueii ei?aoaaeei , o 55 ae?oae aei aeuaaeacaieo i?aia?ao?a i?e?aeioaaee a?aeiia?aeii aei aeiia i?aeia?iaeiiai eiinainono c ae?aaiinoeee oa e?eoaaiiy ?ei?o?a i?noeaa? e?iiiie , oii?eaeuei? noa?i?aee aai ?io? iaaeeeaiaioe. Oai??, ui iaea?aeoaaee neiioiiaoe/io oa?ai?th - 20 ae?oae (aaeacie?i, iaoo?c?i ? ?io? i?aia?aoe), neeaaeaee eiio?ieueio a?oio. Ae?aaiic naciiiiai aea?a?eiiai ?ei?oo noaaeee ia i?aenoaa? aea?aieia?/iiai aiaiiaco, oeiiaeo ee?i?/ieo neiioii?a ? niaoe?aeueieo iaoiae?a aeine?aeaeaiiy. Noa?aiii c?a?aiee aiaiiac aeicaiey? cae/aeii cai?aeic?eoe ae?aaiic iie?iico. Ia? cia/aiiy iaoyaeaia aea?aieia?/ieie caoai?thaaiiyie niaaeeia?noue. O 69,1% ae?oae niinoa??aaany iaoyaeaiee n?iaeiee aiaiiac, /ano?oa ii iaoa?einuee?e (63.8 % ), i?ae ii aaouee?anuee?e e?i?? (22.4%), aai ii iaio e?i?yo (13.8%) . *an iiyae neiioii?a, ?o ae?aci?noue, o?eaae?noue ia?aa?ao a ni?anoaaeaii? c i?iaaaeaiei aea?aieia?/iei aeine?aeaeaiiyi aeicaieeee aeae?eeoe oae? oaee? iie?iico: · aaniyii-e?oiy - 74 aeeoeie ( 54.5 %) · e?oiy -33 ae?oae (24.2% ) · in?iiy- 29 ae?oae (21.3% ) Na?aae ianoaaeaieo ae?oae ia?aaaaeaee oeii/eee (61,7%). E?eoe/iei a?eii oi?ioaaiiy caoai?thaaiiy aoa oe?eueiee, a naia-i?aioaa?oao oa ioaa?oao. E?euee?noue aeiaaee?a NA? c?inoaea c? ca?eueoaiiyi ?ie?a aeeooy, ui ni?aiaaea? c aeaieie e?oa?aoo?e (Aberg, 1989, Schafer and Ring ,1995). Aiaiiac ia?oiai ?ieo aeeooy na?ae/eoue i?i oa, ui aeiiioaieie ia?iaeeeeny 86,7% ae?oae, a iaaeiiioaieie -13,3%. ??ciiiai?oi? aeaee iaoieia?? aaa?oiino? ? iieia?a a?aecia/aeeny o 15,3%, ia?eiaoaeueia aioeaoaeiiao?y - o 12,7% ae?oae.Ia ooo/iiio aeaiaeiaoaaii? ciaoiaeeeeny 50,8 % ae?oae, ia ci?oaiiio – 19,5% , ia i?e?iaeiiio aeaiaeiaoaaii? –29,7%. Oaeei /eiii, aea?a?ei? ?aaeoe?? ia??aeei oi?iothoueny ia oii? ia?eiaoaeueii? iaoieia??. Ia? cia/aiiy oa?aeoa? aeaiaeiaoaaiiy ae?oae ia ia?oiio ?ioe? aeeooy. A?aeiii, ui ia oi?ioaaiiy aea?a?eieo caoai?thaaiue aieeaathoue iiia?aaei? ? noiooi? oai?iae, iniaeeai a ?aiiueiio a?oe? (Aaeaaiee?i ?.?.,1994,Nieieiaa O.N.,1986). Ia ia?oiio ?ioe? aeeooy ae?oae, ye? niinoa??aaeenue, caoai?thaaiiy a?iioieaaaiaaiai aia?aoo aeyaeyeenue o 74,1%, ui iia'ycaii c iniaeeainoyie aeeoaeueii? oa ?ioiii? nenoai ? noeeuei?noth aei /anoeo A?A?, ui iiaeooue oneeaaeithaaoeny a?iio?oaie aai iiaaiii?yie. Aea?aieia?/iee aiaiiac na?ae/eoue i?i oa, ui a 40,5% ae?oae aecia/aeeny ??ciiiai?oi? aeaee ae?aoac?a, oi/a aiaoeaoi?ii /ano?oa anueiai noaaeany ae?aaiic “aenoaeaoeaii-eaoa?aeueiee ae?aoac” (AEAe). C noiooi?o caoai?thaaiue o ianooii? ?iee caa?oathoue ia naaa oaaao iiaoi?i? caoai?thaaiiy a?iioieaaaiaaiai aia?aoo (40,5%), caoai?thaaiiy EI?-i?aai?a (16,9%), oeoieiai-eeoeiaiai o?aeoo (11,8%) aeeoy/? ?ioaeoe?? (30,8%). Iiaoi?i? a??onii-aaeoa??aeuei? ?ioaeoe?? aeeoaeueiiai aia?aoo iiaeooue neoaeeoe aeaea?aeii aeiaeaoeiai? nainea?e?caoe??, ui ocaiaeaeo?oueny c aeoieith E.E.Ceiia’?aa ? ni?aaao. (1988). A ee?i?/i?e ea?oei? naciiiiai aea?a?eiiai ?ei?oo a?aoiaoaaee oae? neiioiie: /oaiiy, naa?a?ae o iin?, ?eii?ay, iiae?aciaiiy i/ae, neueiciaeae?eaiiy, oioioia?y, eaoaeue, a?ia?ai?y iiniaeioeiaiai e?eueoey. O ae?oae, ui ia?aaoaaee i?ae niinoa?aaeaiiyi, ?cieueiaaiee ?ei?o cono??/aany ??aeei. O 85 ae?oae - (62.2 %) aea?a?eia caiaeaiiy iioe?thaaeiny ia iiniaeioeo, ai?oaiue, ?anoao??a? o?oae, oiaoi i?io?eaei o aeaeyae? aea?a?eii? ??iineioniiao??. ?cieueiaaiee aea?a?eiee ?ei?o /ano?oa niinoa??aaany o i?aee?oe?a. O 16 ae?oae (13.2%) NA? noi?iaiaeaeoaaany a?iioiniaciii. Ca oyaee?noth ia?aa?ao iaoieia?? oai?? ?iciiae?eyeeny oaeei /eiii: · eaaeee ia?aa?a o 48 ae?oae (35.3%) · na?aaeiuei? oyaeeino? o 61 aeeoeie (44.8%) · oyaeeee ia?aa?a o 27 ae?oae ( 19.9%) O 95 ae?oae i?iaiaeeeany ?eiineii?y. Aeyaeyee iaa?ye neeciaeo iaieiiie ii?iaeieie iina, iaa?ye na?aaei?o ? ieaei?o iiniaeo ?aeiaei. Neeciaa iaieiiea /ano?oa iaea ae?aei-n??ee eie?? ?c ia?io?iaei iaethieii ? aeeneo/ith iiaa?oiath, ??aeoa niinoa??aaeeny ae?aei-?iaeaaee /e neithoiee eie?? neeciai? iaieiiee. A?ia?ai?y neeciai? iaieiiee /ano?oa aeyaeyeany iaeii/anii c A?C. Oa?aeoa? nae?aoo ia?aaaaeii i?ici?ee, aiaeyienoee, a cia/i?e e?eueeino?, ??aeoa – aonoee, o iacia/i?e e?eueeino?. O 53 ae?oae i?iaiaeeee oeeoieia?/ia aeine?aeaeaiiy iiniaiai nae?aoo. I?noeaaa aiceiio?e?y aeyaeyeanue o 43,5% ae?oae c aea?a?eiei ?ei?oii . Aeine?aeaeaiiy caaaeueiiai aiae?co e?ia? ia aeyaeei oeiiaeo aeey aaeoa??aeueieo ?ioaeoe?e “caiaeueieo” ci?i. Oi?ioea e?ia? a?aeiia?aeaea a?eo. Aiceiio?e?y ia?eoa?e/ii? e?ia? aecia/aeany o 60,2% ae?oae. A?aeiioaiiy aei aiceiio?e?? ia?eoa?e/ii? e?ia? ye iieacieea aoii??, iaiaeiicia/ia . Iao? niinoa?aaeaiiy na?ae/aoue i?i aenieo /anoioo aeyaeaiiy aiceiio?e?? e?ia?, iniaeeai, i?e aaaaoie?aoieo aeine?aeaeaiiyo. Eiao?oe??io ei?aeyoe?? i?ae aiceiio?e??th ia?eoa?e/ii? e?ia? ? caaaeueieie ??aiyie Jg A neeaa r=0,358 (?<0,05 ), i?ae aiceiio?e??th oa niaaeeiaith noeeuei?noth aei aea?a?? r=0,452 (p<0,01), oiaoi aiceiio?e?y iiaea neoaoaaoe aeineoue ?ioi?iaoeaiei iieacieeii iayaiino? aea?a??, ui ni?aiaaea? c aeaieie e?oa?aoo?e ( Lowell, 1978, Eaneoey I.?., 1982 ). A oaaeeoe? 1 iaaaaeai? ?acoeueoaoe nea?eo?eaoe?eieo oe??ieo oano?a c ieeeiaeie aea?aaiaie a?o/eciyiiai ae?iaieoeoaa (III”?ioiieia”), ye? na?ae/aoue, ui aeey ae?oae c iie?iicii oa?aeoa?ia iie?aea?a?y ? iaea?eueoa /enei iiceoeaieo ?aaeoe?e ae?aaeaii? ?ioaineaiino? aecia/a?oueny ia aea?aaie ceaeiaeo o?aa- einoa? i?yiee, ?aea?an ianiaeuiee, ?aea ca??ia, oeiio??aea, eieoaeeue eoeiaeo o?aa. Iaea?eueoith oaeeath iie?iico aeey ae?oae i. Ee?aa ? Ee?anei? iaeano? ? aaniyii-e?oiy (54,5%). Iaeiei ?c aaiaoe/ieo ia?ea??a aoii?? ? i?aeaeuaiee ??aaiue caaaeueiiai ?g A o ne?iaaooe? e?ia? (Aeaeoiaeia A.A. ? ni?aaao., 1990).Ie aeyaeee i?aeaeuaiiy ??aiy caaaeueiiai Ig E o 61,5 % ae?oae c NA?, ui ni?aiaaea? c aeaieie ?ioeo aaoi??a (Norman, 1985) Ioe?ithth/e ??aaiue caaaeueiiai Jg A o ae?oae aa?oi i?aee?aneeoe, ui eiai i?aeaeuaiiy aacoiiaii na?ae/eoue i?i aoii?th ( Vanacore, 1996 ). I?ioa, ca e?oa?aoo?ieie aeaieie, o iieiaeie ae?oae c aea?a?eiei ?ei?oii ??aaiue caaaeueiiai Jg A o ne?iaaooe? e?ia? iiaea caeeoaoeny a iaaeao ii?ie . A?aeiii, ui caaaeueiee ??aaiue Jg A c a?eii ca?eueoo?oueny (U.Wahn, 1998). Aeey ae??oaiiy caaaeaiue i?i aoaeoeai?noue ? aaciaeo niaoeeo?/ii? oa?ai?? i?e NA? ie i?iaaee N?O oa i?iaiae?coaaee ?? ?acoeueoaoe a eaoaiiac? o 47 ae?oae. A?eueo?noue ae?oae neeaaeaee oeii/eee oe?eueiiai a?eo (32 ?c 47). I?e iinoaiiaoe? ae?aaiico NA? a?aoiaoaaany n?iaeiee aea?aieia?/iee aiaiiac (niaaeeiaa noeeuei?noue aei aea?a?? aoea i?enooiy o 84% ae?oae), ee?i?/ia ea?oeia (/oaiiy, iniaeeai ia?ieneciaeueia, naa?a?ae, iiae?aciaiiy ii?iaeieie iina, ??ii?ay, caeiaeai?noue iino, eio?? /anoi noi?iaiaeaeo? eii’thieoea?o, naa?a?ae ? iiae?aciaiiy i/ae, oioioia?y). Ii oyaeeino? caoai?thaaiiy ?iciiae?e oai?eo aeaeyaeaa o oaeee niin?a: eaaeee nooi?iue oyaeeino?: - 19 ae?oae, na?aaei?e -18 ae?oae, oyaeeee -10 ae?oae. O 9 ae?oae oe??e a?oie, i?e caaino?aii? iie?iico, e??i ?ei?oo,niinoa??aaany a?iioinianoe/iee neiae?ii. O 47 ae?oae niinoa??aaeeny iiceoeai? NOI c ??ciiiai?oieie aea?aaiaie ? ??ciiiai?oii? ?ioaineaiino? a 275 aeiaaeeao, oaeei /eiii iiiiaea?a?y ?a?no?oaaeany ??aeei. Cia/ii /ano?oa a?aecia/aeany nainea?e?caoe?y aei aeae?eueeio ieeeiaeo aea?aai?a. ?acoeueoaoe, io?eiai? a iaoiio aeine?aeaeaii?, na?ae/aoue i?i aenieo aoaeoeai?noue N?O o ae?oae ?c NA?. Iiceoeaiee ee?i?/iee ?acoeueoao io?eiaii o 91,3% ae?oae, i?e/iio o 17 ae?oae (36,2%) i?ney i?iaaaeaiiy eo?no e?eoaaiiy caaino?aiue iie?iico a ia??iae oea?o?iiy ia niinoa??aaeiny, o ?ioeo ae?oae ee?i?/ia neiioiiaoeea cia/ii ciaioeeany, a iio?aaa a iaaeeeaiaioici?e oa?ai?? cieceeany. I?ae aieeaii N?O a??ia?aeii i?aeaeuoaaeany e?euee?noue AAN-?OE - 24,1+1,6 aei e?eoaaiiy i?ioe 28,8+1,4 i?ney e?eoaaiiy, a oaeiae ??aaiue oaio?e?i-?acenoaioieo ee?oei, 33,7+3,2, (?<0,05) i?ioe 43,3+2,2 (? <0,05), ???ia/aeiny noaoenoe/ii cia/eia ca?eueoaiiy ??aiy Jg G (a?aeiia?aeii c 724,8+30,9 aei 808,8+20,1 , ?<0,05) i?inoaaeoaaeany oaiaeaioe?y aei ca?eueoaiiy A-?OE, oaio?e?i-/ooeeaeo ee?oei , a oaeiae ??aiy ?ioiiaeiaoe?i?a A ? I. Caaaeueiee ??aaiue Jg A aei e?eoaaiiy ia?aaeuoaaa ii?io o 12 ae?oae ?c 18 ianoaaeaieo. I?ney e?eoaaiiy i?aeaeuaiee ai?no JgA caa??aaany o?eueee a 5 ae?oae. Cieaeaiiy Jg A o aeeiai?oe? o eiaeiiai eiie?aoiiai oai?iai niinoa??aaeiny o 72,3% oai?eo, i?i ui na?ae/eoue oaeiae aeinoia??ia ??cieoey na?aaei?o aaee/ei (82,3+18,9 aei e?eoaaiiy i?ioe 41,3+7,1 i?ney iueiai, ?<0.05). Caa?oa?ii oaaao ia oa, ui a?eueo aenieo aoaeoeai?noue, ca aeaieie e?oa?aoo?e, aea? iiaoi?ia canoinoaaiiy N?O (?aayeeia A.A.,1989). O iaoiio niinoa?aaeaii? i?ioeaio a?aei?iieo ? aa?ieo ?acoeueoao?a o eaoaiiac? aia?oa i?iaaaeaiiai N?O (72,4%) aoa aeuei, i?ae i?e iiaoi?ieo eo?nao oa?ai?? (54,5%). I?ioa, yeui a?aooaaoe, ui na?aae aia?oa i?ie?eiaaieo 41% neeaee ae?oe c eaaeei ia?aa?aii NA? ( 15 ?c 34), a na?aae i?ie?eiaaieo iiaoi?ii ?o ia aoei, oi caaaeueiee aeniiaie i?i aoaeoeai?noue iiaoi?ieo eo?n?a N?O iiaea aooe i?aeoaa?aeaeaiee. O ae?oae ?c na?aaeiueith aaaee?noth ? oyaeeei ia?aa?aii iie?iico eo?ne ia?aaenaciiii? N?O aeioe?eueii iiaoi?thaaoe. O iaoiio aeine?aeaeaii? iia?/i? ?aaeoe?? N?O ca?a?no?iaai?, a oe?eiio, o 6 ae?oae ?c 47 (12,7%). C ieo o?eueee a 1 aeeoeie aeiaaeiny i?eieieoe ?ioiioa?ai?th. Oea ua ?ac i?aeoaa?aeaeo? aeoieo a?o/eciyieo aaoi??a i?i a?aeiinio aaciaeo aeaiiai iaoiaeo oa?ai?? a ?oeao niaoe?ae?noa-aea?aieiaa. (Aouei ?.N.,1997,Iooeee A.I.,1998, Caeeia N.A., 1998) Ca aeaieie e?oa?aoo?e a?aeiii, ui e?au? ?acoeueoaoe N?O aeinyaathoueny o aeiaaeeo iiiiaea?a??, aea oaea neooaoe?y cono??/a?oueny ae?ae ??aeei. Oiio ie ei?enooaaeeny i?eeiyoei i?aaeeii N?O- ia canoiniaoaaoe a?eueoa 3 aea?aai?a a?ae?aco. Aoaeoeai?noue N?O i?e NA? o ae?oae iieacaia o iaoeo aeine?aeaeaiiyo ? o aaaaoueio e?oa?aoo?ieo iia?aeiieaiiyo (Kupa A.,1992, Naeeiia Y.E.,1989), i?e aeinoaoi?e aaciaoe? aeaiiai iaoiaeo o aeiaaeeo eiai aeeiiaiiy niaoe?ae?noii-aea?aieii, aea? iiaio i?aenoaao i?ecia/aoe ia?aaenaciiio N?O o ae?oae c iaoith iiia?aaeaeaiiy naciiiiai caaino?aiiy. *ei ?ai?oa aiia i?ecia/a?oueny, oei a?eueoa a??ia?aei?noue iiceoeaiiai ee?i?/iiai aoaeoo. Aei?a/ii i?eaaaeaoe, ui ia aeoieo ?.N. Aoueia (1997) ? aaaaoueio ?ioeo aaoi??a, N?O aeyaey? oaeo oa?aiaaoe/io ae?th, yea iioe?th?oueny ia an? aoaie aea?a?/ii? a?aeiia?ae? ? a?aenooiy o a?aeiieo oa?iaeieia?/ieo i?aia?ao?a, o oiio /ene? oeo, ui iathoue iie?ooieoe?iiaeueio aeoeai?noue (Caeeia N.A., 1998). Cieaeaiiy a aeeiai?oe? e?eoaaiiy i?noeaai? ? caaaeueii? aiceiio?e??, cieaeaiiy ??aiy Jg A, a oaeiae aeeiai?ea iieaciee?a ee?oeiii? eaiee ?ioi?oaoo, iiaeooue ?icaeyaeaoenue ye i?aeoaa?aeaeaiiy iiceoeaieo ?ioiieo c?ooaiue aiane?aeie N?O. Oeaio?aeueia i?noea a iaaeeeaiaioici?e oa?ai?? NA? caeiathoue inoaii?i /anii aioea?noai?ii? i?aia?aoe iiaiai iieie?iiy, aei yeeo a?aeiinyoueny acaeanoei ? ei?aoaaeei. Aia?oa ia Oe?a?i? ie aecia/aee ee?i?/io aoaeoeai?noue ? aaciaeo ei?aoaaeeia o ae?oae ?c NA?. C iiaeaieo aeaieo (oaae.2) i/aaeaeii, ui i?ae aieeaii ei?aoaaeeia oaeaeei cieeathoue /oaiiy, ??ii?ay, naa?a?ae, a oaeiae neiioiie aea?a?eiiai caiaeaiiy i/ae ? iiniaeioee, iaioa ae?aaeaiee aieea i?aia?aoo ia caeeaaeai?noue iino (?<0,05). Oaaeeoey 2. Aeeiai?ea /anoioe ee?i?/ieo neiioii?a a i?ioean? e?eoaaiiy ei?aoaaeeiii (a aaeao) Neiioi-ieE-noue aeioaeAei e?eoaaiiy i?ney e?eoaaiiy ?(1,4)?(2,5)?(3,6)0-1(1)2(2)3(3)0-1(4)2(5)3(6)Aan. %Aan. %aan. %aan. %aan.%aan %*oaiiy 172 11,767 41,188 47,0614 11,82 82,31 5,9p<0,01p<0,05p<0,01 Naa?a?ae 142 14,35 35,77 5012 85,61 7,21 7,2p<0,01p<0,05p<0,05 ?eii?ay 123 253 256 5011 91,72 8,30 0p<0,001p<0,05p<0,05 Iacaeueia A?ia?a-i?y 111 91 99 824 36,44 36,42 18,2p<0,05p>0,05p<0,01 Iiae?ac-iaiiy I/ae 182 11,12 11,114 77,89 507 38,92 11,1p<0,05P<0,05 p<0,01 Neueici-aeae?eai-iy 172 11,82 11,813 76,48 47,18 47,11 5,8p<0,05 P<0,05p<0,01 Oioi-oia?y 101 102 207 707 700 03 30p<0,01p<0,05 p<0,05 Eaoaeue 112 18,24 36,45 45,48 72,72 18,21 9,1p<0,01 p>0,05p<0,01 Caeea-aeaii?noue Iino 91 11,13 33,45 55,55 55,51 11,13 33,4p<0,05 P<0,05p>0,05 A?ia?a-i?y

Iini-aeioee223

13,610

45,59

40,99

40,98

36,45

22,7P<0,05 p>0,05P<0,05 Aoaeoeai?noue i?aia?aoo o e?ea?aeaoe?? aino?eo neiioii?a NA? i?aeoaa?aeaeo?oueny aeaieie ?eiineii??, cieaeaiiyi i?noeaai? aiceiio?e?? (c 30,3+6,3 aei 7,0+3,2, ?<0,01). A oe?eiio, iiceoeaia ae?y ei?aoaaeeia a?aecia/a?oueny a 92,3% ae?oae, oi/a ye iiiioa?ai?y a?i aeei?enoiao?oueny i?e eaaeiio ia?aa?ao caoai?thaaiiy (25,7%). Ei?aoaaeei aeia?a eiia?io?oueny c ?ioeie e?ea?nueeeie i?aia?aoaie. Eiai iiaeia canoiniaoaaoe aeiaaino?ieiai. O iaoiio aeine?aeaeaii? o?eaae?noue eo?no ia ia?aaaaeaea 2 i?nyoe?. Ca aeaieie e?oa?aoo?e (Gambardella R., 1993, Pechadre J.C. et al. 1991 ), i?e iaiao?aeiino? i?aia?ao iiaeia canoiniaoaaoe i?ioyaii 6-12 i?nyoe?a. I?ae aieeaii ei?aoaaeeia cieaeo?oueny ae?aaeai?noue oe??ieo oano?a ia a?ia?/ooeea?noue aei ieeeiaeo aea?aai?a , ui i?aeoaa?aeaeo? aioeaea?a?eio ae?th i?aia?aoo. Ie ia a?aecia/aee niieeaino?, iani?eyoeeaiai aieeao ia i?ciaaaeuei? iiaeeeaino? ? ineoiiioi?i? ooieoe?? a aeiaeiiio c aeiaaee?a canoinoaaiiy ei?aoaaeeia o aeaeyae? iiiioa?ai?? oa o eiiieaen? c ?ioeie i?aia?aoaie. Aiaeia?/ii, naaeaoeaia ae?y ia ca?a?no?iaaia i?e i?noeaaiio canoinoaaii? acaeanoeia. I?noeaaa canoinoaaiiy acaeanoeia a?ae?ioei?eaea ii aoaeoeaiino? iaiinooia?oueny ia?i?aeueiiio eo?no ei?aoaaeeia.( iae.1) Iii?oiee aoaeo niinoa??aa?oueny ia 5-7 aeaiue e?eoaaiiy. Caa?oa? ia naaa oaaao iiceoeaiee aieea acaeanoeia a?ae?ioei?eaeo ia caeiaeai?noue iino, i?ioiaeei?noue iiniaeo oiae?a (?<0,001) E??i noa'?eoeaiiai ciaioaiiy nea?a niinoa??aa?oueny noaoenoe/ii cia/eia cieaeaiiy aioo??oiueiiiniaiai iii?o. Aei canoinoaaiiy aeea?aiaeeeo iiniaee ii?? neeaaeaa 56,06+2,58, i?ney canoinoaaiiy i?aia?aoo 44,32+2,9 (?<0,001). Iaeee aieea ia?i?aeueieo aioea?noai?iieo i?aia?ao?a ia caeiaeai?noue iino ? ?oi?i aieiaiei iaaeie?eii, oiio iiceoeaia ae?y acaeanoeia ia “aeieaaeiee?a” aecia/a? eiai ia?aaaao. C a?eueoith a??ia?aei?noth, aoaeo iia'ycaiee c i?noeaaith ae??th ia eieaeueia neoi/aiiy ee?oei-aiceiio?e?a, aacio?e?a, iaeo?io?e?a, ui oa?aeoa?ii aeey NA?. Iai?yiei na?ae/aiiyi oiio neoaeeoue cieaeaiiy nae?aoi?ii? aiceiio?e?? (9,2+4,3 i?ioe 32,2+10,4 , ?<0,05).Niinoa??aaeinue oaeiae cieaeaiiy caaaeueiiai ??aiy ne?iaaoeiaiai Jg A i?ae aieeaii aioea?noai?iieo cania?a, i?ioa oeae oaeo aaaeei ca'ycaoe o?eueee c aieeaii i?aia?aoo. C a?eueoith a??ia?aei?noth aeeiai?ea Jg A a?aeaeaa? ia?aa?a naiiai iaoieia?/iiai i?ioeano. Aeinoia??ieo ci?i ?ioeo iieaciee?a aoii?aeueii? eaiee ?ioi?oaoo i?ae aieeaii aioea?noai?iieo i?aia?ao?a ia aeyaeaii. Aieiaiei i?eioeeiii iaaeeeaiaioicii? oa?ai?? NA? o aeaiee /an ? iiaoaiiee i?aeo?ae aei i?ecia/aiiy i?aia?ao?a o caeaaeiino? a?ae aaaeeino? ia?aa?ao caoai?thaaiiy. Aea?? i?aia?ao?a a?oioo?oueny ia iniaeeainoyo iaoiaaiaco (?aaeoe?y a?ia?/ooeeaino? iaaaeiiai oeio, ui aecia/a? iniaeeaino? caiaeaiiy) ? neiioiiao NA?, ye? ia?aaaaeathoue. ( Internacional consensus report on diagnosis and management of rhinitis. Allergy, 1994; 49: Suppl. 19 : 1-34). Ia? cia/aiiy a?e oai?iai, noiooi? caoai?thaaiiy, noaaeaiiy iaoe??io?a ? aeeiiaiiy ieie i?ecia/aiiai ?aaeeio, iniaeeai o ae?oae oe?eueiiai a?eo. C iaeyaeo ia aeuaaeeeaaeaia, ie i?iiiio?ii ?ic?iaeaiee iaie oa?aiaaoe/iee aeai?eoi e?eoaaiiy naciiiiai aea?a?eiiai ?ei?oo ia iniia? aea/aieo i?aia?ao?a . AENIIAEE 1.Niaoeeo?/ia ?ioiioa?ai?y ? aoaeoeaiei iaoiaeii e?eoaaiiy ae?oae c NA?, i?i ui na?ae/eoue iiaia cieeiaiiy (36,2%) aai cieaeaiiy naciiieo caaino?aiue, ciaioaiiy ae?aaeaiino? ee?i?/ieo neiioii?a. ?acoeueoaoeai?noue N?O caeaaeeoue a?ae aaaeeino? ia?aa?ao NA?, nooiaith ae?aaeaiino? iie?aea?a??, no?ie?a i?ecia/aiiy e?eoaaiiy.I?ae aieeaii N?O a?aei?/a?oueny iiceoeaia aeeiai?ea iieaciee?a ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo, cieaeaiiy caaaeueiiai ??aiy IgA a ne?iaaooe? e?ia?, ui iiaea na?ae/eoe i?i ciaioaiiy nainea?e?caoe??. Iia?/i? ?aaeoe?? ia N?O a?aei?/aeeny o 12,7% ae?oae, c ieo caaaeuei? o 8,5%, i?noeaa? o 4,2%. A?aei?ia niaoeeo?/ii? ?ioiioa?ai?? i?iaiaeeeanue eeoa o 1 aeeoeie ?c 47, ui e?eoaaeenue. 2.Iieacaiiyie aei i?ecia/aiiy N?O ? aa?eo?eaoe?y ae?aaiico NA?, iayai?noue naciiieo caaino?aiue o?eaae?noth ia iaioa 3 i?nyoe?a, ye? iio?aaothoue uiaeaiii? oa?iaeioa?ai??, iaiaaeaia /enei ?ioaineaieo iiceoeaieo ?aaeoe?e ia ieeeia? aea?aaie (aaaeaii ia a?eueoa 3). 3.Ia?oo e?i?th iaaeeeaiaioicii? oa?ai?? i?e caaino?aii? NA? neeaaeathoue aioea?noai?ii? caniae iiaiai iieie?iiy – ei?aoaaeei ? acaeanoeia a?ae?ioei?eae, ye? iiceoeaii aieeaathoue ia ee?i?/i? neiioiie caoai?thaaiiy – /oaiiy, naa?a?ae o iin?, ?eii?ath, iiae?aciaiiy i/ae, neueiciaeae?eaiiy, oioioia?th, eaoaeue. Aoaeo i?aeneeth?oueny i?e ii?aeiaiiio aeei?enoaii?. Naaeaoeaiee aoaeo ei?aoaaeeio ? acaeanoeio a aeaiiio aeine?aeaeaii? ia ca?a?no?iaaiee. O 3,4% ae?oae, ye? e?eoaaeeny acaeanoeiii, a?aei?/aeanue iia?/ia ae?y a aeaeyae? a??eioe a ?io?, /oaiiy, iiniai? e?iaioa/?. 4.I?noeaaee aioea?noai?iiee i?aia?ao iiaiai iieie?iiy- acaeanoeia a?ae?ioei??ae-i?ecia/a?oueny ye ia?oa e?i?y iaaeeeaiaioiciiai e?eoaaiiy NA?.I?ae aieeaii acaeanoeia a?ae?ioei?eaea, a aeaeyae? iacaeueiiai ni?ay, niinoa??aa?oueny iiceoeaia aeeiai?ea ee?i?/ieo neiioii?a NA?, cieaeaiiy i?noeaai? aiceiio?e??, ciaioaiiy aioo??oiueiiacaeueiiai iii?o. 5.Naciiiee aea?a?eiee ?ei?o o ae?oae i.Ee?aa ? Ee?anueei? iaeano? oa?aeoa?eco?oueny niaaeeiaith noeeuei?noth (69,1%), iayai?noth i?aeaeuaiiai ??aiy Ig A a ne?iaaooe? e?ia? (61,5%), caaaeueiith oa i?noeaaith aiceiio?e??th, ia?aaaaith ?iciianthaeaeaii? ?eiineioniiao?? a ii?aeiaii? c i/ieie neiioiiaie (62,2%) iaae ?cieueiaaiei ?ei?oii. E?eoe/iei a?eii aeieeiaiiy NA? ? i?aioaa?oaoiee ia??iae. Iaea?eueoa /enei iiceoeaieo ?aaeoe?e ae?aaeaii? ?ioaineaiino? a?aei?/a?oueny ia aea?aaie ceaeiaeo o?aa. 6.?ic?iaeaiee oa?aiaaoe/iee aeai?eoi naciiiiai aea?a?eiiai ?ei?oo c i?aeeeth/aiiyi ia?aaenaciiii? niaoeeo?/ii? ?ioiioa?ai?? oa iiaoaiiiai aeei?enoaiiy iaaeeeaiaioicieo cania?a a caeaaeiino? a?ae aaaeeino? ia?aa?ao caoai?thaaiiy caaacia/o? aenieo aoaeoeai?noue e?eoaaiiy (86,2%). A ia??iae caaino?aiiy o 69,8% ae?oae aaeaeiny iaiaaeeoeny eeoa aioea?noai?iieie i?aia?aoaie iiaiai iieie?iiy. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aa?eo?eaoe?y ae?aaiico naciiiiai aea?a?eiiai ?ei?oo, iayai?noue naciiieo caaino?aiue o?eaae?noth ia iaio 3 i?nyoe?a, ye? iio?aaothoue uiaeaiii? oa?iaeioa?ai??, iaiaaeaia e?euee?noue ?ioaineaieo iiceoeaieo ?aaeoe?e ia ieeeia? aea?aaie (aaaeaii ia a?eueoa 3) ? i?aenoaaith aeey i?iaaaeaiiy niaoeeo?/ii? ?ioiioa?ai?? o ae?oae i?e a?aenooiino? caaaeueiii?eeiyoeo i?ioeiieacaiue. 2. Ia?oo e?i?th iaaeeeaiaioicii? oa?ai?? i?e caaino?aii? naciiiiai aea?a?eiiai ?ei?oo neeaaeathoue aioea?noai?ii? i?aia?aoe iiaiai iieie?iiy. Acaeanoeia a?ae?ioei?eae o aeaeyae? iacaeueiiai ni?ay ? ei?aoaaeei aeey ia?i?aeueiiai aeei?enoaiiy iiaeooue i?ecia/aoenue ye iiiioa?ai?y aai ii?aeioaaoenue c ?ioeie i?aia?aoaie aeey ca?eueoaiiy aoaeoeaiino? e?eoaaiiy.Eo?n aioea?noai?iieo i?aia?ao?a iiaea aooe iiaeiaaeaiee aei 6 i?nyoe?a i?ney cieeiaiiy ee?i?/ieo neiioii?a caaino?aiiy NA? c i?io?eaeoe/iith oe?eeth. 3. Iayai?noue ae?aaeaieo oa ??ciiiai?oieo neiioii?a iie?iico (ia?aaaaeaiiy eii’thieoeaaeueiiai ? a?iioinianoe/iiai neiae?ii?a ), yaey?oueny iieacaiiyi aeey i?ecia/aiiy eiia?iiaaii? oa?ai?? caaino?aiue naciiiiai aea?a?eiiai ?ei?oo, yea aeeth/a? e?iiiie aeey i?noeaaiai aeei?enoaiiy, oii?eaeuei? noa?i?aee ? neiioiiaoe/i? caniae. 4. Ca?aeii c i?aeia?iaeiei eiinainonii c aeeaaiinoeee oa e?eoaaiiy ?ei?o?a, ?aeiiaiaeo?oueny canoinoaaiiy iiaoaiii? oa?ai?? NA? a caeaaeiino? a?ae aaaeeino? ee?i?/ieo ceiioii?a. Oeae i?eioeei aoei iieeaaeaii a iniiao noai?aiiai aeai?eoio. Cai?iiiiiaaiee aeai?eoi e?eoaaiiy NA? caaacia/o? aenieo aoaeoeai?noue eiai canoinoaaiiy. O 32,6 % ae?oae, i?ney eo?no ia?aaenaciiii? niaoe?o?/ii? ?ioiioa?ai?? ( N?O ), caaino?aiue NA? i?ae /an oea?o?iiy ia niinoa??aaeiny, o 36,2% neiioiie ?ei?oo aoee iaei ae?aaeaieie, aeey ?o e?ea?aeaoe?? aoei aeinoaoiuei i?noeaaiai canoinoaaiiy acaeanoeia a?ae?ioei?eaeo. O ?aooe ae?oae aeei?enoiaoaaeenue ?io? i?aia?aoe aeacaii? noaie, aea o?eueee o 12,4% - oii?eaeuei? noa?i?aee. ?acoeueoaoe oa?iaeioa?ai?? caeaaeaee a?ae nooiaith aaaeeino? NA?. NIENIE ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. No/ani? aniaeoe ae?aaiinoeee ? e?eoaaiiy aea?a?/iiai ?ei?oo o ae?oae o na?oe? i?aeia?iaeiiai eiinainona 1994 ?ieo // ?ioiieia?y oa aea?aieia?y –1998.-?1.- C.109-114. 2. No/ania oyaeaiiy i?i naciiiee aea?a?/iee ?ei?o ( iie?iic ) o ae?oae //E?ee Oe?a?ie-1999.-? 2.-N.69-72. 3. Aoaeoeai?noue ? aacia/i?noue niaoe?o?/ii? a?iinainea?e?caoe?? i?e aea?a?/iiio ?ei?o? o ae?oae. //E?ee Oe?a?ie -1999.-? 3. C.69-72 4. Aoaeoeai?noue i?noeaaiai canoinoaaiiy aea?aiaeeea iacaeueiiai ni?ath i?e aea?a?/iiio ?ei?o? o ae?oae .//?ioiieia?y oa aea?aieia?y 1998.- ? 4. C.86-90. 5. Niaoe?o?/ia oa ianiaoe?o?/ia a?iinainea?e?caoe?y i?e iie?iicao o ae?oae. //Ca??iee iaoeiaeo i?aoeue OO tha?eaeii? eiioa?aioe?? iieiaeeo a/aieo EIAII –1997-C.349-353. 6. Aoaeoeai?noue niaoe?o?/ii? oa ianiaoe?o?/ii? a?iinainea?e?caoe?? i?e iie?iicao o ae?oae. // 1 I?aeia?iaeiee eiia?an nooaeaio?a oa iieiaeeo a/aieo –1997-C.74-75 7. Aoaeoeai?noue niaoe?o?/ii? oa ianiaoe?o?/ii? a?iinain?a?e?caoe?? i?e iie?iicao o ae?oae. // C*?cae ooec?ao??a ? ioeueiiiieia?a Oe?a?ie –1998- C.81 8. Aoaeoeai?noue niaoe?o?/ii? oa ianiaoe?o?/ii? a?iinain?a?e?caoe?? i?e iie?iicao o ae?oae. // 7 iaoe?iiaeueiee eiia?an c oai?ia i?aai?a aeeoaiiy Iineaa,1997 ?. C15. 9. Aoaeoeai?noue ianiaoe?o?/ii? a?iinainea?e?caoe?? o e?eoaaii? aea?a?/iiai ?ei?oo o ae?oae. // Aeooaeuei? ieoaiiy i?e?io??o?a?? aooa oa caoai?thaaiue aa?oi?o aeeoaeueieo oeyo?a .-1997- C.96-97. 10. The epidemiological monitoring of bronchial asthma children in Kiev city. //Allergy European journal of allergy and clinical immunology 1998,N 43, volume 53, P.188 11.Effectiveness of claritin in the treatment of seasonal allergic rhinitis ( pollinosis ) in the children. //Allergy European journal of allergy and clinical immunology.-1997.-N 37. Volume 52. P.211 AIIOAOe?ss Ae?aaea Aa?ei?aeo. Aoaeoeai?noue niaoe?o?/ii? oa ianiaoe?o?/ii? a?iinainea?e?caoe?? i?e iie?iicao o ae?oae.-?oeiien. Aeena?oaoe?y ia caeiaoooy a/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.10. – Iaae?ao??y. – Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i.I.I.Aiaiiieueoey,Ee?a, 1999. Aeena?oaoe?y i?enay/aia eiiieaeni?e oa?ai?? naciiiiai aea?a?eiiai ?ei?oo o ae?oae c aeeth/aiiyi niaoe?o?/ii? ?ioiioa?ai?? oa iiaoaiiiai canoinoaaiiy iaaeeeaiaio?a a caeaaeiino? a?ae aaaeeino? caoai?thaaiiy. Aoaeoeaiei iaoiaeii e?eoaaiiy ? niaoe?o?/ia ?ioiioa?ai?y,i?ae aieeaii yei? niinoa??aa?oueny ia o?eueee iie?auaiiy ia?aa?ao NA?,aea e ?ioiieia?/ia ia?aaoaeiaa. Cai?iiiiiaaiee oa?aiaaoe/iee aeai?eoi caaacia/o? aenieo aoaeoeai?noue ( 86,2% ) e?eoaaiiy. O 69.8% ae?oae o ia??iae? caaino?aiiy aaeaeiny aeinyaiooe iiceoeaieo ?acoeueoao?a,canoiniaoth/e aioea?noai?ii? i?aia?aoe iiai? aaia?aoe?? – ei?aoaaeei oa acaaeanoeia a?ae?ioei?eae – i?noeaai oa ia?i?aeueii o aeaeyae? iiiioa?ai?? aai a ii?aeiaii? c ?ioeie i?aia?aoaie.O iaoe??io?a c aeoaea ae?aaeaieie aai ??ciia?/ieie neiioiiaie iaiao?aeia eiiieaenia oa?ai?y. Eeth/ia? neiaa: a?iinainea?e?caoe?y, niaoe?o?/ia ?ioiioa?ai?y,naciiee aea?a?eiee ?ei?o, iie?iic, aioea?noai?ii? i?aia?aoe, oa?aiaaoe/iee aeai?eoi. AIIIOAOeEss Yeeaaea Ya?eieaeo. Yooaeoeaiinoue niaoeeoe/aneie e ianiaoeeoe/aneie aeiinaineaeeecaoeee i?e iieeeiicao o aeaoae.-?oeiienue Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.10 – Iaaeeao?ey.- Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei. A.A. Aiaiiieueoea, Eeaa, 1999. Oeaeueth aeenna?oaoeeiiiie ?aaiou yaeeinue oniaa?oainoaiaaiea iaoiaeia eiiieaeniie oa?aiee naciiiiai aeea?ae/aneiai ?eieoa (NA?) o aeaoae n eniieueciaaieai i?aaenaciiiie niaoeeoe/aneie eiioiioa?aiee e iaaeeeaiaioiciuo n?aaenoa a ia?eiaea iaino?aiey. Aeey auiieiaiey iinoaaeaiiuo caaea/ iiae iaaethaeaieai iaoiaeeeinue 136 aeaoae n NA? a aic?anoa io 5 aei 14 eao. Aeeaaiic NA? aa?eoeoee?iaai ia iniiaaiee aeea?aieiae/aneiai aiaiiaca, oeie/iuo eeeie/aneeo neiioiiia e niaoeeaeueiuo iaoiaeia enneaaeiaaiey. Niaoeeaeueiua iaoiaeu aeea?aieiae/aneiai e eiioiieiae/aneiai enneaaeiaaiey aeeth/aee eiaeiua nea?eoeeaoeeiiiua oanou aeia?/oanoaeoaeueiinoe iaiaaeeaiiiai oeia n iueueoeaauie aeea?aaiaie ioa/anoaaiiiai i?iecaiaenoaa, ii?aaeaeaiea iieacaoaeae eeaoi/iiai e aoii?aeueiiai eiioiiiai ioaaoa, iauee o?iaaiue nuai?ioi/iiai Jg E, ecia?aiea aioo?eiacaeueiiai nii?ioeaeaiey iaoiaeii ieeoeioiao?ee, enneaaeiaaiea OAAe, oeeoieiae/aneia enneaaeiaaiea nae?aoa. Naciiiue aeea?ae/aneee ?eieo o aeaoae a.Eeaaa e Eeaaceie iaeanoe oa?aeoa?ecoaony ianeaaenoaaiiie i?aae?aniieiaeaiiinoueth (69,1%), iaee/eai iiauoaiiiai o?iaiy JgE a nuai?ioea e?iae (61,5%), iauae e ianoiie yiceiioeeeae, i?aiaeaaeaieai ?ani?ino?aiaiiie ?eiineioniiaoee a ni/aoaiee n aeaciuie neiioiiaie (62,2%) iaae eciee?iaaiiui ?eieoii. E?eoe/aneei aic?anoii aicieeiiaaiey NA? yaeyaony i?aioaa?oaoiue ia?eiae. Iaeaieueoaa /enei iiceoeaiuo eiaeiuo ?aaeoeee au?aaeaiiie eioaineaiinoe ioia/aaony ia aeea?aaiu ceaeiauo o?aa. I?iaiaeece?iaaiu ?acoeueoaou e aaciianiinoue i?aaenaciiiie niaoeeoe/aneie eiioiioa?aiee a eaoaiiaca. Niaoeeoe/aneay eiioiioa?aiey yaeyaony yooaeoeaiui iaoiaeii ea/aiey aeaoae n NA?, i /ai naeaeaoaeuenoaoao iieiia en/aciiaaiea (36,2%) eee nieaeaiea naciiiuo iaino?aiee, oiaiueoaiea au?aaeaiiinoe eeeie/aneeo neiioiiia. ?acoeueoaoeaiinoue NEO caaeneo io oyaeanoe oa/aiey NA?, noaiaie au?aaeaiiinoe iieeaeea?aee, n?ieia iacia/aiey ea/aiey. Iiae aeeyieai NEO ioia/aaony iieiaeeoaeueiay aeeiaieea iieacaoaeae eeaoi/iiai e aoii?aeueiiai eiioieoaoa, nieaeaiea iauaai o?iaiy JgE a nuai?ioea e?iae, /oi iiaeao naeaeaoaeuenoaiaaoue ia oiaiueoaiee naineaeeecaoeee. Iiai/iua ?aaeoeee ia NEO ioia/aeenue o 12,7% aeaoae, ec ieo iauea o 8,5%, ianoiua -4,2%. Ioiaia niaoeeoe/aneie eiioiioa?aiee i?iecaaaeaia oieueei o 1 ?aaaiea ec 47 ea/eaoeony. Iieacaieyie aeey iacia/aiey niaoeeoe/aneie eiioiioa?aiee yaeythony aa?eoeeaoeey aeeaaiica naciiiiai aeea?ae/aneiai ?eieoa, iaee/ea naciiiuo iaino?aiee aeeeoaeueiinoueth ia iaiaa 3 ianyoeaa, o?aaothueo aaeaaeiaaiie oa?iaeioa?aiee, ia?aie/aiiia /enei eioaineaiuo iieiaeeoaeueiuo ?aaeoeee ia iueueoeaaua aeea?aaiu (aeaeaoaeueii ia aieaa 3). I?iaiaeece?iaaiu ?acoeueoaou ea/aiey aeaoae n NA? aioeaenoaieiiuie i?aia?aoaie iiaiai iieieaiey- ei?aoaaeeiii ia?i?aeueii e acaeanoeiii (ianoii), a aeaea iiiioa?aiee e a ni/aoaiee. I?aia?aou iieiaeeoaeueii aeeytho ia eeeie/aneea neiioiiu caaieaaaiey- /eoaiea, coae a iino, ?eii?ath, ?acae?aaeaiea aeac, neaciioaeaeaiea, oioioiaeth, eaoaeue.Yooaeo oneeeaaaony i?e ni/aoaiiii i?eiaiaiee.Naaeaoeaiue yooaeo ei?aoaaeeia e acaeanoeia a ianoiyuai enneaaeiaaiee ia ca?aaeno?e?iaai. O 3,4% aeaoae , eioi?ua ea/eeenue acaeanoeiii,ioia/aeenue iiai/iua aeaenoaey acaeanoeia a aeaea ai?a/e a ?oo, /eoaiey, iiniaiai e?iaioa/aiey. Ianoiue aioeaenoaieiiue i?aia?ao iiaiai iieieaiey-acaeanoeia aeae?ioei?eae iacia/aaony eae ia?aay eeiey iaaeeeaiaioiciiai ea/aiey NA?. Ianoiia i?eiaiaiea acaeanoeia aeae?ioei?eaea ii yooaeoeaiinoe ia onooiaao ia?i?aeueiiio eo?no ei?aoaaeeia. Ia?auaao ia naay aieiaiea iieiaeeoaeueiia aeeyiea acaeanoeia aeae?ioei?eaea ia caeiaeaiiinoue iina, i?ioiaeeiinoue iiniauo oiaeia Iiieii noauaeoeaiiai oiaiueoaiey aeaeia iaaethaeaaony noaoenoe/anee cia/eiia nieaeaiea aioo?eiiniaiai nii?ioeaeaiey (niioaaonoaaiii 56,06+2,58 e 44,32+2,9, ?<0,001), nieaeaiea nae?aoi?iie yiceiioeeee (9,2+4,3 i?ioea 32,2+10,4 , ?<0,05). Iaeia aeeyiea ia?i?aeueiuo aioeaenoaieiiuo n?aaenoa ia caeiaeaiiinoue iina yaeyaony eo aeaaiui iaaeinoaoeii, iiyoiio iieiaeeoaeueiia aeaenoaea acaeanoeia ia “aeieaaeieeia” ninoaaeyao aai i?aeiouanoai. I?aaeeiaeaiiue oa?aiaaoe/aneee aeai?eoi NA? iaania/eaaao aunieoth yooaeoeaiinoue ea/aiey. O 32.6% aeaoae iinea eo?na i?aaenaciiiie NEO iaino?aiey NA? a ia?eiae oeaaoaiey ia iaaethaeaeinue, o 36.2% neiioiiu ?eieoa auee iaei au?aaeaiiuie, a aeey eo eeeaeaeaoeee aeinoaoi/ii auei ianoiiai i?eiaiaiey aeea?aiaeeea aeae?ioei?eaea.O inoaeueiuo aeaoae i?eiaiyeenue ae?oaea i?aia?aou oeacaiiie noaiu, ii oieueei o 12,4% -oiieeaeueiua noa?ieaeu. ?acoeueoaou oa?iaeioa?aiee caaenaee io noaiaie oyaeanoe NA?. Eeth/aaua neiaa: aeiinaineaeeecaoeey, niaoeeoe/aneay eiioiioa?aiey, aioeaenoaieiiua i?aia?aou, iieeeiic, naciiiue aeea?ae/aneee ?eieo. ANNOTATION Evripidou Eliada. Efficiency of specific and non specific immunotherapy of pollinosis to the children.”manuscript Thesis for medical science candidate degree in speciality 14.01.10 - pediatrics.-The National Medical University named A.A. Bogomolets, Kiev, 1999. The dissertation is devoted to the complex therapy of seasonal allergic rhinitis of the children with the inclusion of specific immunotherapy and the graduate application of medical preparation depending on the depth of the disease. An effective method of treatment is specific immunotherapy , which under its influence the reorganization is observed not only improving of current seasonal allergic rhinitis(SAR) , but also immunological changes Offered therapeutical algorithm witch ensures high efficiency treatment (86,2 %). At 69,8 % of children in period of a peaking it was possible to achieve positive result, using antihistamine preparations of a new generation -loratadin & azelastine-hydrochloride localy and per-os as monotherapy or in a combination with other preparations.Patients with hardly expression or diverse symptoms the therapy needed to be combinational. Key words: specific immunotherapy, seasonal allergic rhinitis, pollinosis, antihistamine preparations, therapeutical algorithm IA?AE?E NEI?I*AIUe AEAe-aenoaeaoeaiee eaoa?aeueiee ae?aoac A?A?-aino?a ?ani??aoi?ia a??onia ?ioaeoe?y ANEO-aino?ee noaiicoth/ee ea?eiaio?aoa?o N?O-niaoe?o?/ia ?ioiioa?ai?y NA?-naciiiee aea?a?eiee ?ei?o NOI-nea?eo?eaoe?ei? oe??i? i?iae ISAAC-International study of asthma and allergies in childhood IgA- ?ioiiaeiaoe?i eeano A IgM- ?ioiiaeiaoe?i eeano I IgG - ?ioiiaeiaoe?i eeano G IgE - ?ioiiaeiaoe?i eeano A

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