2

AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO OOEC?AO??? ? IOEUeIIIIEIA?? ?i.O.A.ssIIANUeEIAI

NAEACIAIEI Oaoyia Oae?en?aia

OAeE: 616.24-002:547:586.2.001.6

AOAEOEAI?NOUe I?AIA?AOO OAEII A EI?AEOe?? NENOAIE AAIINOACO I?E
CAOAI?THAAIIssO EAAAIUe

14.01.27 — ioeueiiiieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? ooec?ao??? ? ioeueiiiieia?? ?i. O.A.
ssiianueeiai AII Oe?a?ie (aee?aeoi? — aeaaeai?e AII Oe?a?ie, aeieoi?
iaaee/ieo iaoe,

i?ioani? TH.?. Oauaiei).

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Aaa?enthe Aieiaeeie? Einoyioeiiae/,
caa?aeoaa/ ee?i?ei-ooieoe?iiaeueiei a?aeae?eaiiyi ?inoeoooo ooec?ao??? ?
ioeueiiiieia??

?i. O.A.ssiianueeiai AII Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eaneoey Ieueaa ?ea??ii?aia;
caa?aeoaa/ea eaoaae?e iaae?ao??? ?1 Ee?anueei? iaaee/ii? aeaaeai??
i?neyaeeieiiii? ina?oe IIC Oe?a?ie;

aeieoi? iaaee/ieo iaoe, i?ioani? Na?ioe?oeueeee Aiaoie?e Noai?neaaiae/,
caa?aeoaa/ eaoaae?e aini?oaeueii? oa?ai?? ?2 Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo

?i. I.I. Aiaiiieueoey.

I?ia?aeia onoaiiaa:

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, eaoaae?a ooec?ao??? oa
ioeueiiiieia??.

Caoeno a?aeaoaeaoueny «18» n?/iy 1999 ?. i 14-00 aiaeei?

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.552.01 i?e ?inoeooo?
ooec?ao??? ? ioeue-iiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie (252000,
i. Ee?a, INI-650, oca?c I?ioan?a ss?, 7).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
ooec?ao??? ? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie (252000, i.
Ee?a, oca?c I?ioan?a ss?, 7).

Aaoi?aoa?ao ?ic?neaiee «17» a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee AE.A. Aaaioe?aa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

AEOOAEUeI?NOUe OAIE. A iaoiaaiac? cia/ii? e?eueeino? caoai?thaaiue
i?aai?a aeeoaiiy aaaeeeao ?ieue a?ae?a?a? neiae?ii a?ia?eiaaoeyoe??
e?ia?. Iei noi?iaiaeaeothoueny iiaaiii??, a?iioiiano?oeoeai?
caoai?thaaiiy, ai?ei? i?ioeane (Iaea?aae/ A.Y., 1985; Aeaieeia E.I.,
1989). Ua a?eueoa cia/aiiy neiae?ii a?ia?eiaaoeyoe?? ia? i?e
o?iiaiaiaie?? eaaaiaai? a?oa??? oa iia’ycai?e c iath eaaaiaa?e
a?ia?oaic?? (Neiae?oeaa N.A., Aaeyeia I.A., 1986; Naaaeueaa A.N.,
1990). Ii?ooaiiy nenoaie cai?oaiiy e?ia? ? /anoei oneeaaeiaiiyi
o??o?a?/ieo ao?o/aiue ia a?iioao e eaaaiyo (Palevsky H.I., 1990;
Mozer K.M., 1992). Ana oea coiiaeth? aeooaeuei?noue ?ic?iaee iiaeo
e?ea?nueeeo i?aia?ao?a a?iieiaaoeyoe?eii? oa aioeaa?aaaioii? ae??.

A ?acoeueoao? ai?aeai?ieia?/ieo aeine?aeaeaiue, i?iaaaeaieo a 70-?–80-?
?iee, aoa iii?/aiee ae?ae iecueeee ??aaiue o?iiaic?a ? o?iiaiaiaie?e o
iaoeaioe?a ocaa??aeaey A?aieaiae??, ssiii?? oa aeayeeo ?ioeo e?a?i
(Dyerberg J., Band H.O., 1979; Kromhout D., 1983). A ianooiiiio aoei
anoaiiaeaii, ui i?e/eiith cieaeaiiy cai?oaiiy e?ia? ? aaeeaaiiy c
?aeath aaeeei? e?eueeino? ii?nueei? ?eae oa i’yna ii?nueeeo
nnaaoe?a, ye? i?noyoue aaeeeo e?euee?noue iiaaa-3 iie?iaiane/aieo
aee?ieo eeneio (IIAEE) — aeeicaiaioa?iiai? oa aeieicaaaena?iiai?
(Ahmed A.A., 1984; Hirai A., 1984). I?e oeueiio ci?ie noaio
cai?oath/i? nenoaie e?ia? iia’ycai? ye ?c ciaioaiiyi ?? a’yceino?
(Kovayashi S., 1981), aeoeaaoe??th o?a?eiie?co (Schmidt E.B., Dyerberg
J., 1994), ciaioaiiyi i?ieiaaoeyoe?eiiai aieeao o?eae?oea?eae?a
(Bradon G.A., 1990), oae e aieeaii ia ??aaiue o?iiaiaa?aaaoe??
(Bradlow B.F., 1983).

Iaea?eueoei /eiii aea/aiee aieea iiaaa-3 IIAEE ia noai aa?aaaoe?eii?
caeaoiino? o?iiaioeeo?a, yea coiiaeaia ?o eiieo?aioieie a?aeiioaiiyie
aei a?ao?aeiiiai? eeneioe i?e aeeth/aii? a no?oeoo?o ee?oeiieo iaia?ai
(Weber P., Fisher S., 1986). E??i oeueiai, oa?iaio iaoaaie?cio
a?ao?aeiiiai? eeneioe oeeeeiieneaaiaca aeo?a/a?oueny e ia ieeneaiiy
iiaaa-3 IIAEE, a ?acoeueoao? /iai ciaioo?oueny i?iaeoeoe?y iiooaeiiai
?iaeoeoi?o aa?aaaoe?? o?iiaioeeo?a o?iiaienaio A2 (iaoaaie?o
a?ao?aeiiiai? eeneioe) ? ca?eueoo?oueny ai?no a e?ia? o?iiaienaio A3
(iaoaaie?o iiaaa-3 IIAEE), yeee ia ia? o?iiaiaa?aaaoe?eii?
aeoeaiino? (Srivastava K.C., 1985). Iaoai?cie aieeao iiaaa-3 IIAEE ia
?io? eaiee cai?oath/i? nenoaie e?ia? aea/ai? iaaeinoaoiuei.

O O?aioe??, NOA oa ?yae? ?ioeo e?a?i a oaia??oi?e /an aeionea?oueny
e?ea?nueeee i?aia?ao MaxEPA, yeee i?noeoue 30 % iiaaa-3 IIAEE. A ?in??
ae?iaey?oueny i?aia?ao Yeeiiie i?eaeecii aiaeia?/iiai neeaaeo.

A ?inoeooo? ooec?ao??? ? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII
Oe?a?ie ?ic?iaeaiee i?aia?ao Oaeii, yeee i?noeoue 45 % iiaaa-3 IIAEE
(aeicaieaiee aei iaaee/iiai canoinoaaiiy Oa?iaeieia?/iei
eii?oaoii IIC Oe?a?ie). I?aia?ao ia? ia?aaaae ia?aae MaxEPA
oa Yeeiiieii ? ca ye?niei neeaaeii, ine?eueee i?noeoue iaioo
e?euee?noue IIAEE eeano iiaaa-6, ye? iathoue eiieo?aioi? aeanoeaino?
ii a?aeiioaiith aei eeano iiaaa-3 IIAEE.

Oey ?iaioa ? o?aaiaioii aenia?eiaioaeueiiai oa ee?i?/iiai aea/aiiy
i?aia?aoo.

IAOA ?IAIOE: aea/eoe aieea iiaiai e?ea?nueeiai i?aia?aoo Oaeii ia
iieacieee aaiinoaco o oai?eo ia caoai?thaaiiy eaaaiue.

CAAAeAIIss AeINE?AeAEAIIss:

1. Aeine?aeeoe a?iieiaaoeyoe?eio ae?th i?aia?aoo Oaeii ia
aenia?eiaioaeuei?e iiaeae? caiaeueiiai i?ioeano a eaaaiyo.

2. Aea/eoe aieea i?aia?aoo Oaeii ia noai aa?aaaoe?eii? ooieoe??
o?iiaioeeo?a o oai?eo ia caoai?thaaiiyo eaaaiue a i?iaao in vitro.

3. Aecia/eoe iiaeeeaino? ei?aeoe?? noaio cai?oath/i? nenoaie e?ia? i?e
canoinoaaii? i?aia?aoo Oaeii o oai?eo ia caoai?thaaiiy eaaaiue ?c
neiae?iiii a?ia?eiaaoeyoe?? a ee?i?/ieo oiiaao.

IAOEIAA IIAECIA ?IAIOE.

Aea/aiee aieea ?ic?iaeaiiai ca i?ea?iaeueii? oaoiieia??th iiaiai
(iaoaio Oe?a?ie N 7180A, IIE-5 A61E35/60 a?ae 16.03.95 ?.) e?ea?nueeiai
i?aia?aoo Oaeii ia iieacieee cai?oath/i? nenoaie e?ia? ia
aenia?eiaioaeuei?e iiaeae? caiaeueiiai i?ioeano a eaaaiyo, o oai?eo ia
caiaeuei? caoai?thaaiiy i?aai?a aeeoaiiy a i?iaao in vitro oa a
ee?i?/ieo oiiaao. Aeiaaaeaia iayai?noue o i?aia?aoo Oaeii
a?iieiaaoeyoe?eii? oa aioeaa?aaaioii? ae??.

I?AEOE*IA CIA*AIIss ?ACOEUeOAO?A ?IAIOE, AI?IAAAeAEAIIss A I?AEOEEO.

Aeiaaaeaia iiaeeea?noue iiaeaethaaiiy neiae?iio a?ia?eiaaoeyoe?? e?ia?
i?e caiaeueiiio i?ioean? a eaaaiyo a aenia?eiaio? ia uo?ao. Oey iiaeaeue
iiaea aooe aeei?enoaia a ?iaio? ii aea/aiith iiaeo e?ea?nueeeo
i?aia?ao?a a?iieiaaoeyoe?eii? oa aioeaa?aaaioii? ae??.

I?iaaaeaia ?iaioa ? o?aaiaioii i?ia?aie iaoeiaeo aeine?aeaeaiue
ii ?ic?iaoe? i?aia?aoo Oaeii, yeee i?eeiyoee aei ae?iaieoeoaa AO
«Ee?anueeee a?oai?iiee caaiae». Ai?iaaaeaeaiiy a i?aeoeeo c o?aooaaiiyi
eiai a?iieiaaoeyoe?eii? oa aioeaa?aaaioii? ae?? ia? ni?eyoe i?aeaeuaiith
aoaeoeaiino? e?eoaaiiy oai?eo ia caoai?thaaiiy i?aai?a aeeoaiiy c
neiae?iiii a?ia?eiaaoeyoe?? e?ia?.

?acoeueoaoe ?iaioe ai?iaaaeaeaii a ?inoeooo? ooec?ao??? ? ioeueiiiieia??
?i. O.A. ssiianueeiai AII Oe?a?ie oa Ee?i?/i?e e?ea?i? iaooiia?a?iaii?
i?iieneiaino? IIC Oe?a?ie.

AI?IAAOe?ss ?IAIOE. Iniiai? iieiaeaiiy aeena?oaoe?? aeiiia?aeaeenue ia
?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? «Iiaua aeinoeaeaiey a
?aiiae aeeaaiinoeea e oa?aiee ainiaeeoaeueiuo caaieaaaiee i?aaiia
aeuoaiey, i?aaeoi?aaeaeaiea o?iiecaoeee caaieaaaiee» (Oa?ueeia, 8-9
/a?aiy 1995 ?.), Iaoe?iiaeueiiio eiia?an? ii oai?iaai i?aai?a
aeeoaiiy (Iiainea??nuee, 1-4 eeiiy 1996 ?.), iaoeiai-i?aeoe/i?e
eiioa?aioe?? ?inoeoooo ooec?ao??? ? ioeueiiiieia?? ?i. O.A.ssiianueeiai
AII Oe?a?ie (eenoiiaae, 1996 ?.).

IOAE?EAOe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 iaoeiaeo
i?aoeue.

EIIE?AOIEE INIAENOEE AIANIE AeENA?OAIOA

Iniaenoee aianie caeeth/a?oueny o ?ic?iaoe? an?o iaoeiaeo ?acoeueoao?a.
Aenia?eiaioaeuei? aeine?aeaeaiiy aoee i?iaaaeai? ca aaciina?aaeiueith
iniaenoith o/anoth aaoi?a. An? oai?? ciaoiaeeeenue i?ae iniaenoei
niinoa?aaeaiiyi aeena?oaioa. Naiino?eii i?iaaaeaiee aiae?c
aenia?eiaioaeueieo ? ee?i?/ieo aeaieo, noaoenoe/ia ia?iaea iaoa??aeo.
Aeneiaeth?ii ue?o iiaeyeo i?ioani?o ?inoeoooo ooec?ao??? ?
ioeueiiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie ?.?.Noneiao, e.i.i.
N.I.Ieaiiao, e.i.i. N.?.Eauaiei, a oaeiae ni?a?ia?oieeai eaai?aoi???
a?io?i?? ?inoeoooo na?oeaai-noaeeiii? o??o?a?? I.N.Caaei?iaei?e oa
I.N.Ineiaiei ca ni?eyiiy o aeeiiaii? ?iaioe.

IANssA ? NO?OEOO?A AeENA?OAOe??.

Aeena?oaoe?y aeeeaaeaia ia 130 noi??ieao iaoeiiieniiai oaenoo,
?ethno?iaaia 4 oaaeeoeyie ? 13 iaethieaie. Neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, aeaio ?icae?e?a iniaenoeo aeine?aeaeaiue,
cae?i/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo e?oa?aoo?e,
yeee i?noeoue 197 aeaea?ae ?ioi?iaoe??.

CI?NO ?IAIOE

IAOA??AEE ? IAOIAeE AeINE?AeAEAIUe. Iiaeaethaaiiy ianiaoeeo?/iiai
caiaeueiiai i?ioeano a eaaaiyo aoei i?iaaaeaia ca iaoiaeeeith
I.A.Caoa?ueaaneie oa I.I.Aie/eiaa (1952) ia 15 aacii?iaeieo uo?ao
ianith 250-300 a. Nooue iaoiaeeee caeeth/a?oueny a ?iieaioaoe?? a
i?ina?o o?aoa? ?ii?iaeiiai o?ea (ieanoeeiai? ieoee).

Aea/aiiy aieeao i?aia?aoo Oaeii ia iieacieee cai?oath/i? nenoaie e?ia? o
oai?eo ia caoai?thaaiiy eaaaiue a i?iaao in vitro oa a ee?i?/ieo
oiiaao aoei i?iaaaeaia o 67 oai?eo (/ieia?e?a — 45, ae?iie — 22) o
a?oe? a?ae 22 aei 74 ?ie?a. ?iciiae?e oai?eo a caeaaeiino? a?ae
iicieia?/ii? oi?ie caoai?thaaiiy iaaaaeaiee a oaaeeoe? 1.

A?eueo?noue ianoaaeaieo (38,8 %) neeaee oai?? ia o?ii?/iee iano?oeoeaiee
a?iio?o. Ne?ae a?aei?oeoe, ui o?ii?/iee iano?oeoeaiee a?iio?o ye noiooi?
caoai?thaaiiy niinoa??aaany o aaaaoueio oai?eo c ?ioeie iicieia?/ieie
oi?iaie.

Oai?? ciaoiaeeeenue ia ianoaaeaii? oa e?eoaaii? a
ee?i?ei-ooieoe?iiaeueiiio,

Oaaeeoey 1 — ?iciiae?e oai?eo a caeaaeiino? a?ae oa?aeoa?o caoai?thaaiiy

Oa?aeoa? caoai?thaaiiyE?euee?noue oai?eo
aan.%O?ii?/iee iano?oeoeaiee a?iio?o2638,8Ooaa?eoeueic
eaaaiue1420,9Aii??ia ieaa?e913,4 Aino?a iiaaiii?y68,9 O?a?icoth/ee
aeueaaie?o46,0 A?iioiaeoaoe/ia oai?iaa3 4,5Ia?aeiia
eaaaiaaa a?ia?oaic?y34,5O?ii?/ia iinoaiaie?/ia eaaaiaaa a?ia?oaic?y

2

3,0Anueiai67100

1-io oa?aiaaoe/iiio oa o??o?a?/iiio a?aeae?eaiiyo ?inoeoooo.

Ae?aaiic caoai?thaaiiy aoa anoaiiaeaiee ia i?aenoaa? aeaieo ee?i?/iiai,
?aioaaiieia?/iiai iaoiae?a, aeaeo?iea?ae?ia?ao??, aoiea?ae?ia?ao?? ?
eaai?aoi?ieo aeine?aeaeaiue, a iaiao?aeieo aeiaaeeao — a?iioieia?/iiai
oa ?ioeo ae?aaiinoe/ieo iaoiae?a.

Oai?ei, ye? iinooiaee a noaoe?iia?, i?ecia/aee oa?ai?th o
a?aeiia?aeiino? c oa?aeoa?ii iniiaiiai caoai?thaaiiy, a oaeiae
e?eoaaiiy, ni?yiiaaia ia ciaioaiiy na?oeaai? aeaeiiiainaoe?? (na/ia?ii?
caniae, ia?eoa?e/i? aaciae?eyoaoi?e).

Aea/aiiy aieeao i?aia?aoo Oaeii ia iieacieee cai?oath/i? nenoaie e?ia? a
ee?i?/ieo oiiaao i?iaiaeeee i?ney e?ea?aeaoe?? aeoeaiino? caiaeueiiai
i?ioeano ? noaa?e?caoe?? ooieoe?iiaeueiiai noaio ea?ae?i?ani??aoi?ii?
nenoaie. Oaeii i?ecia/aee ia oii? i?aeo?eioth/i? oa?ai??.

I?e oeueiio i?aia?aoe, ye? cae?eniththoue aieea ia noai cai?oath/i?
nenoaie e?ia? (ani??ei oa ?io? ianoa?i?aei? i?ioecaiaeuei? caniae,
ei?oeeinoa?i?aee, ae?i??eaeaiie oa ?io? aioeaa?aaaioe, aaia?ei), ia
canoiniaoaaeenue.

Aiae?c noaio cai?oath/i? nenoaie e?ia? i?iaiaeeee c aeei?enoaiiyi
ianooiieo oano?a:

1. *ano cai?oaiiy e?ia? ca iaoiaeii Ath?ea?a (nae).

2. I?io?iia?iiaiai /ano (nae).

3. O?iia?iiaiai /ano (nae).

4. Ai?noo o?a?eiiaaio (a/e) ca iaoiaeeeith ?.A. ?ooaa?aa.

5. Aioeeiaaoeyoe?eiiai oanoo c ?ic?aooieii aiie?ooaee e?eai? ia 8-e
oaeeei? oa ?iaeaeno ?iaeoeaaoe?? o?iia?io.

6. Aoaiieiaiai oanoo (oi.iae.) ca iaoiaeeeith A.I. Aaeoaee.

7. Ai?noo ?ic/eiiiai o?a?eio (oi. iae.) ca iaoiaeeeith A.I.Aaeoaee.

8. Aa?aaaoe?eii? caeaoiino? o?iiaioeeo?a ca oi?o?eiaaieie
?aeiiaiaeaoe?yie aei aa?aaiiao?o «Chrono-log» (Eaiaaea, 1983)
(Cardinal).

A nee?eiiia? i?ia??ee c 3,8 % ?ic/eiii oeeo?aoo iao??th iaae?aee e?ia ii

5 ie o eiaeio, i?ney /iai iaeio na??th i?ia??ie caeeoaee ye
eiio?ieueio, a ?ioo aeiaeaaaee i?aia?ao Oaeii a aeic? 0,1 ie. Aeica
i?aia?aoo aoea aecia/aia, aeoiaey/e c ?acoeueoao?a iiia?aaeiueiai
aea/aiiy oa?iaeie?iaoeee iiaaa-3 IIAEE c oei ?ic?aooieii, uia eiai
eiioeaio?aoe?y a e?ia? neeaaeaea a na?aaeiueiio 2 %, ui a?aeiia?aea?
na?aaeiueioa?aiaaoe/i?e aeic? (I.A. Iuae, I.A. A?aoeeaineee, 1991).
Aeine?aeaeaiiy i?iaiaeeee i?ney ia??iaeo aeaioaiaeeiii? ?ieoaaoe?? c
aeei?enoaiiyi noaiaea?oieo iaai??a ?iaeoeoi??a aa?aaaoe?? o?iiaioeeo?a.

A yeino? iciae a?ia?aa?aaaoe?? o?iiaioeeo?a o a?aeiia?aeue ia ae?th
?iaeoeoi?a AAeO a aeic? 2 ieiieue/e ?icaeyaeaee a?aenooi?noue oace
aeacaa?aaaoe?? ia e?ea?e, i?e oeueiio iieaciee aa?aaaoe?? (A)
aei??aithaaa noia?iiio ?iaeaeno aa?aaaoe?? o?iiaioeeo?a (N?AO).

sse ??cei ae?aaeaio a?ia?aa?aaaoe?th o?iiaioeeo?a o?aeooaaee iiyao
ae?oai? oaee? aa?aaaoe??, i?e oeueiio aaee/eia N?AO ia?aaeuoaaea
iieaciee A.

Aeico ?iaeoeoi?a, ui aei??aithaaea 5 ieiieue/e,
aeei?enoiaoaaee o aeiaaeeo io?eiaiiy ii?iaeueii? e?eai? o a?aeiia?aeue
ia aeico 2 ieiieue/e aeey aecia/aiiy iiaeeeaeo ii?ooaiue aa?aaaoe?eii?
caeaoiino? o?iiaioeeo?a. A ii?i? ia e?ea?e aa?aaaoe?? o a?aeiia?aeue ia
aeico 5 ieiieue/e AAeO ia niinoa??aa?oueny oaca aeacaa?aaaoe??.
?acoeueoaoe aeine?aeaeaiue ia?iaethaaee iaoiaeaie aa?aoe?eii?
noaoenoeee.

AEA*AIIss A?IIEIAAOEssOe?EII? Ae?? I?AIA?AOO OAEII IA AENIA?EIAIOAEUeI?E
IIAeAE? CAIAEUeIIAI I?IOeANO A EAAAIssO

Iiaeaethaaiiy ianiaoeeo?/iiai caiaeueiiai i?ioeano a eaaaiyo aoei
i?iaaaeaia ia 15 aacii?iaeieo uo?ao. I?ae ao??iei ia?eicii aoa
i?iaaaeaiee ?ic??c iiaa?oiaaeo oeaiei ii ia?aaei?e iiaa?oi? oe?, ooii
a?aenaia?iaoaaee o?aoath ? i?ney ioieoe?? ?? aieeith aaeeeiai ae?aiao?o
a ?? i?ina?o aaiaeeany noa?eeueiee oiaoie ieanoeeiai? ieoee (eanee)
ae?aiao?ii 0,25 ii ? aeiaaeeiith 2,5 ni. C iaoith iiia?aeaeaiiy
a?aeoa?eoaaiiy ?ii?iaeiiai o?ea ieoea cae??iethaaeanue a ?ai? oeyoii
i?aeoeaaiiy aei i’yciaiai eineooo. ?aio caoeaaee.

1-o a?oio (eiio?ieueio) neeaee ?ioaeoi? uo?e (7 oaa?ei), 2-o a?oio —
uo?e, ye? i?ney iia?aoeaiiai ao?o/aiiy io?eioaaee cae/aeiee ?aoe?ii
oa?/oaaiiy (7), 3-th a?oio — uo?e, yeei ia i?ioyc? 30 ae?a i?ney
iia?aoe?? aaiaeeee i?aia?ao Oaeii a aeic? 0,1 a/ea iane o?ea per os.

Caa?? e?ia? aeey aeine?aeaeaiue i?iaiaeeee iaeiiiiiaioii o an?o oaa?ei
/a?ac 1 i?nyoeue i?ney ii/aoeo aenia?eiaioo oeyoii ioieoe?? na?oey a
oiiaao ao??iiai ia?eico. Aeey aeine?aeaeaiiy iaae?aee ii 5 ie e?ia? c
3,8 % ?ic/eiii oeeo?aoo iao??th o ni?aa?aeiioaii? inoaiiueiai aei e?ia?
1:9.

Iayai?noue caiaeueiiai i?ioeano a eaaaiyo aoei i?aeoaa?aeaeaia
?acoeueoaoaie iaoiii?oieia?/ieo aeine?aeaeaiue, ui na?ae/eee i?i
iayai?noue iiaaiii?? oa a?iio?oo. O 25 % oaa?ei caiaeuei? ci?ie
noi?iaiaeaeoaaeenue ai?eieie oneeaaeiaiiyie.

I?e i?e?ineii?/iiio aeine?aeaeaii? oeaiei eaaaiue niinoa??aaeanue
iayai?noue iiaaiii?/ieo aiaieu, cii aaciia?o?yii? oeaieie ?c cai?uaiiyi
ia?aioeie eaaaiue niieo/iioeaieiieie aeaiaioaie. A?eueo?noue aeueaaie
aoee caiiaiai? aeiioii c aaeeeith e?euee?noth aeueaaiey?ieo iae?ioaa?a.
No?iee aeueaaie aoee o?a?ioeciaai?, iaa?yee?.

?acoeueoaoe aea/aiiy a?iieiaaoeyoe?eii? ae?? iiaaa-3 IIAEE ia iiaeae?
caiaeueiiai i?ioeano a eaaaiyo iaaaaeai? a oaaeeoe? 2.

sse aeaeii c oaaeeoe? 2, iiaeaeue caiaeueiiai i?ioeano a eaaaiyo
noi?iaiaeaeoaaeanue ?icaeoeii neiae?iio a?ia?eiaaoeyoe??, i?i ui
na?ae/eoue a??ia?aeia ciaioaiiy /ano cai?oaiiy e?ia?, ca?eueoaiiy
cai?oath/i? aeoeiino? ca aeaieie aooieiaaoeyoe?eiiai oanoo. Ciaioaiiy
/ano cai?oaiiy e?ia? ? ca?eueoaiiy aiie?ooaee aooieiaaoeia?aie
na?ae/eoue, a iniiaiiio, i?i i?enei?aiiy ooai?aiiy aeoeaii? e?iayii?
i?io?iia?iace (o?iiaiieanoeio) ? ia?iuoaaiiy aeoeaiino?
o?iia?io

Ii?o/ c oeei niinoa??aa?oueny cieaeaiiy aioeeiaaoeyoe?eieo aeanoeainoae
e?ia?, ia ui aeaco? nei?i/aiiy o?iia?iiaiai /ano (Aa?aaeai C.N., 1980).

Ca?eueoaiiy i?iaeoeo?a ia?aeiaaoeyoe?? (?ic/eiiee o?a?ei) na?ae/eoue
i?i ?ioaineo?eaoe?th aioo??oiueinoaeeiiiai cai?oaiiy e?ia? (Aiea?aa
E.I., 1989).

I?aeaeuaiiy aeoeaiino? o?iia?iiaiai eiiieaeno (nei?i/aiiy o?iia?iiaiai
/ano), ??aiy ai?noo o?a?eiiaaio a ieaci? yaeythoueny iioaioe?eieie
oaeoi?aie, ye? ni?eythoue ?icaeoeo a?ia?eiaaoeyoe?? e?ia?.

A a?oi? oaa?ei, ye? i?eeiaee i?ney iia?aoeaiiai ao?o/aiiy i?aia?ao
Oaeii, iciaee neiae?iio a?ia?eiaaoeyoe?? e?ia? aoee ae?aaeai? cia/ii
iaioith i??ith. Cie?aia, iieacieee /ano cai?oaiiy e?ia?, o?iia?iiaiai
/ano, ??aiy o?a?eiiaaio aoee aeeae/eie aei aiaeia?/ieo a
eiio?ieuei?e a?oi?.

?acthioth/e io?eiai? aeai?, iiaeia caeeth/eoe, ui iiaeaethaaiiy
caiaeueiiai i?ioeano a eaaaiyo uo??a noi?iaiaeaeo?oueny ?icaeoeii
neiae?iio a?ia?eiaaoeyoe?? e?ia?. Canoinoaaiiy i?aia?aoo Oaeii
a aeic? 0,1 a/ea iane o?ea per os ia i?ioyc? 30 ae?a i?ney
iia?aoeaiiai ao?o/aiiy cia/ii ciaioo? ae?aaeai?noue.

Oaaeeoey 2 — Iieacieee cai?oath/i? nenoaie e?ia? ia iiaeae? caiaeueiiai
i?ioeano a eaaaiyo i?ney e?eoaaiiy i?aia?aoii Oaeii

Iieacieee

Eiio?ieueia

a?oia

(n=7)

Aeine?aeia a?oia aac

e?eoaaiiy

(n=8)

Aeine?aeia a?oia c e?eoaaiiyi

(n=7)*an cai?oaiiy (nae)31,0 1,115,7 0,5*25,0 0,8***I?io?iia?iiaee
/an (nae) 19,4 0,2 8,0 0,3* 12,1 0,5*** O?iia?iiaee /an
(nae)18,00,34,80,3*13,70,8*** O?a?eiiaai (a/e)1,96 0,12,88 0,16*2,25
0,11***Aooieiaaoeyoe?eiee oano ia 8 oa.( % )

46,7 1,29

57,7 1,43*

54,0 1,08*Aoaiieiaee oano:

neaai iiceoeaiee

iiceoeaiee

1

6

8

7?ic/eiiee o?a?ei:

++

+++

++++

2

3

2

8

7

I?ei?oee:

1) * — ??cieoey c iieacieeaie eiio?ieueii? a?oie a??ia?aeia (?<0,05) 2) + - ??cieoey c iieacieeaie oaa?ei 2-? a?oie a??ia?aeia (?<0,05) neiae?iio a?ia?eiaaoeyoe??, ui i?aeoaa?aeaeo? iayai?noue o i?aia?aoo a?iieiaaoeyoe?eieo aeanoeainoae ? coiiaeth? iaiao?aei?noue eiai aea/aiiy a ee?i?/ieo oiiaao. AIEEA I?AIA?AOO OAEII IA IIEACIEEE CAI?OATH*I? NENOAIE E?IA? O OAI?EO IA CAOAI?THAAIIss EAAAIUe. AEA*AIIss AIEEAO I?AIA?AOO OAEII IA ??AAIUe AA?AAAOe?? O?IIAIOeEO?A A I?IAAO IN VITRO C iaoith aea/aiiy aieeao i?aia?aoo Oaeii ia ??aaiue aa?aaaoe?? o?iiaioeeo?a in vitro ianoaaeaiee 51 oai?ee (33 /ieia?ee oa 18 ae?iie) o a?oe? a?ae 22 aei 74 ?ie?a. C ieo o?ii?/iee a?iio?o aoa ae?aaiinoiaaiee o 19, iiaaiii?y - o 6, ooaa?eoeueic eaaaiue - o 10, aii??ia ieaa?e - o 9, o?a?icoth/ee aeueaaie?o - o 4, a?iioiaeoaoe/ia oai?iaa - o 3. sse noiooi? caoai?thaaiiy, ?oai?/ia oai?iaa na?oey niinoa??aaeanue a 12 aeiaaeeao, a?ia?oii?/ia oai?iaa - a 7, ?aaiaoe/i? aaaee na?oey a 3, ae?eyoaoe?eia ea?ae?ii?iiao?y - a 2. O?iiaiaiaie?/i? oa o?iiaioe/i? oneeaaeiaiiy a aiaiiac? a?aei?/aee 12 oai?eo (o?iiaioeaa?o - 7, ?inoeueo - 2, ?ioa?eo i?iea?aeo - 3). O 11 oai?eo aoei aeyaeaii ca?eueoaiiy aaiaoie?eoo a?eueoa 55 % oa aenieee ??aaiue aaiiaeia?io. I?e aeine?aeaeaii? ooieoe?? ciai?oiueiai aeeoaiiy cia/i? ci?ie niinoa??aaeenue o 9 oai?eo, iii??i? - o 31, iacia/i? - o 11. Ca aeaieie aoiea?ae?ia?ao?? iciaee o?ii?/iiai eaaaiaaiai na?oey aoee aeyaeai? a 12 aeiaaeeao. Aeine?aeaeaiiy i?iaiaeeee /a?ac 1 oeaeaeaiue i?ney a?aei?ie i?aia?ao?a, ye? cae?eniththoue aieea ia noai cai?oath/i? nenoaie e?ia? (ani??ei, eo?aioee, noa?i?aee, neieoia??i, oai?e?i). C 51 ianoaaeaiiai oai?iai o 30 in?a aoea aeyaeaia a?ia?aa?aaaoe?y o?iiaioeeo?a, o 9 - ii?iaeueiee noai ? o 12 niinoa??aaeenue iciaee aeacaa?aaaoe??, coiiaeai?, ai/aaeaeue, i?neyae??th iaaeeeaiaio?a. Ioe?iea aieeao i?aia?aoo Oaeii ia noai aa?aaaoe?? aoea i?iaaaeaia o oai?eo c a?ia?aa?aaaoe??th ? ii?iaa?aaaoe??th (39 in?a). Ine?eueee aaee/eia aa?aaaoe?? ? e?euee?nii-ye?niei iieacieeii, ioe?iea ?acoeueoao?a i?iaiaeeeanue a eiaeiiio eiie?aoiiio aeiaaeeo. O 5 oai?eo (12,8 % a?ae caaaeueiiai /enea oai?eo) o aeo?aeiiio noai? aoea aeyaeaia cia/ii ae?aaeaia a?ia?aa?aaaoe?y o?iiaioeeo?a, i?i ui na?ae/eei nooo?aa c?inoaiiy N?AO o ii??aiyii? c iieacieeii A. Oaeei /eiii, e?eaa aa?aaaoe?? iaea aeaioacieo oa?aeoa?: i?ney ia?oi? oaee? aa?aaaoe?? ianooiaea a?eueo ae?aaeaia ae?oaa oaeey. O 25 (64,1%) iaoe??io?a niinoa??aaeanue a?ia?aa?aaaoe?y o?iiaioeeo?a, ui i?iyaeyeinue a?aenooi?noth oace aeacaa?aaaoe?? i?e aeei?enoaii? ?iaeoeoi?o AAeO a eiioeaio?aoe?? 2 ieiieue/e. I?e oeueiio aaee/eia N?AO aei??aithaaea iieacieeo A. A 9 aeiaaeeao (23,1%) aoee ca?a?no?iaai? ii?iaeuei? e?ea? aa?aaaoe?? o?iiaioeeo?a, ia yeeo ca oaeeath aa?aaaoe?? ianooiaea cai?ioiy oaeey aeacaa?aaaoe?? ? iieaciee A ia?aaeuoaaa aaee/eio iieacieea N?AO. O 5 (12,8%) oai?eo e i?ney aeiaeaaaiiy i?aia?aoo Oaeii a?aei?/aia a?ia?aa?aaaoe?y o?iiaioeeo?a, a o 1 (2,6%) oai?iai caa??aaeanue cia/ii ae?aaeaia ?o a?ia?aa?aaaoe?y . Oaeei /eiii, a eiio?ieuei?e na??? i?ia??ie a?ia?aa?aaaoe?y ??ciiai nooiaith aoea ca?a?no?iaaia o 30 oai?eo (76,96,7) %, a i?ney aeiaeaaaiiy i?aia?aoo Oaeii a aeic? 0,1 ie a?ia?aa?aaaoe?y aeyaeyeanue eeoa o 6 iaoe??io?a (15,45,8) %, ?<0,001. A oe?eiio, a i?iaao in vitro Oaeii a aeic? 0,1 ie ia 5 ie oeeo?aoii? e?ia? cia/ii ciaioea aa?aaaoe?eio caeaoi?noue o?iiaioeeo?a o 82,0 % oai?eo. ?acoioth/e io?eiai? aeai? iiaeia caeeth/eoe, ui Oaeii a i?iaao in vitro ia? ae?aaeai? aioeaa?aaaioi? aeanoeaino?, ui coiiaeth? iaiao?aei?noue iiaeaeueoiai aea/aiiy eiai a oiiaao ee?i?ee. AEA*AIIss A?IIEIAAOEssOe?EII? OA AIOEAA?AAAIOII? Ae?? OAEIIO A EE?I?*IEO OIIAAO Ianoaaeaii 16 oai?eo c o?ii?/iei eaaaiaaei na?oeai (12 /ieia?e?a ? 4 ae?iee o a?oe? a?ae 30 aei 62 ?ie?a). C ieo o 7 aoa ae?aaiinoiaaiee o?ii?/iee iano?oeoeaiee a?iio?o, o 4 - o?a?icii-eaaa?iiciee ooaa?eoeueic eaaaiue, o 3 - ia?aeiia eaaaiaaa a?ia?oaic?y, o 2 - o?ii?/ia i?neyaiaie?/ia eaaaiaaa a?ia?oaic?y. Eaaaiaaa iaaeinoaoi?noue III nooiaith niinoa??aaeanue o 3 iaoe??io?a, II nooiaith - o 9 ? I nooiaith - o 4. Iaaeinoaoi?noue e?iaiia?ao IIA noaae?? iaea i?noea a 11 aeiaaeeao, IIA noaae?? - a 5. I?e iinooieaii? aei noaoe?iia?o oai?ei i?ecia/aee ca iieacaiiyie a?iioie?oe/i?, i?ioecaiaeuei? caniae, na/ia?ii?, ea?ae?io?iii? i?aia?aoe. I?ney noaa?e?caoe?? noaio ea?ae?i?ani??aoi?ii? nenoaie ia oii? i?aeo?eioth/i? oa?ai?? (na/ia?ii? caniae, ia?eoa?e/i? aaciae?eyoaoi?e) i?iaiaeeee aeine?aeaeaiiy noaio cai?oath/i? nenoaie e?ia?. Aecia/aiiy iieaciee?a i?iaaaeaia o aeo?aeiiio noai? oa /a?ac 4 oeaei? i?ney i?ecia/aiiy Oaeiio per os a aeic? 4,0 a eiaeiiai aeiy (a ia??iae aeine?aeaeaiiy i?aia?aoe a?iieiaaoeyoe?eii? oa aioeaa?aaaioii? ae?? a eiiieaen? i?aeo?eioth/i? oa?ai?? ia aeei?enoiaoaaeenue). Aeica Oaeiio aoea ia?aia ia i?aenoaa? aeaieo e?oa?aoo?e (Strasser T.H., Fisher S., 1985) i?i iioeiaeueio oa?aiaaoe/io eiioeaio?aoe?th iiaaa-3 IIAEE a e?i?aeieo o?aeoe?yo e?ia? (2 - 2,5 %) c o?aooaaiiyi ?acoeueoao?a aeine?aeaeaiiy oa?iaeie?iaoeee i?aia?aoo Oaeii, i?iaaaeaiiai a ee?i?oe?. Aeeiai?eo iieaciee?a aaiinoaco a i?ioean? e?eoaaiiy ?ethno?o? oaaeeoey 3. sse aeaeii c oaaeeoe?, iieacieee aaiinoaco o aeo?aeiiio noai? na?ae/eee i?i iayai?noue a?ia?eiaaoeyoe?? e?ia? (ca?eueoaiee ai?no o?a?eiiaaio, ?ic/eiiiai o?a?eio, ci?ie aoaiieiaiai oanoo) ? a 12 aeiaaeeao aiai?eee i?i iayai?noue a?ia?-aa?aaaoe?? o?iiaioeeo?a. A i?ioean? e?eoaaiiy oai?eo niinoa??aaeinue a??ia?aeia ciaioaiiy aiie?ooaee aooieiaaoeyoe?eiiai oanoo, cieaeaiiy ??aiy o?a?eiiaaio a e?ia?, ciaioaiiy iciae i?ioeano ia?aeiaaoeyoe?? (aoaiieiaee oano, ?ic/eiiee o?a?ei). A 5 aeiaaeeao c 12-oe niinoa??aaeany iiceoeaia aeeiai?ea oanoo c AAeO-?iaeoeiaaiith aa?aaaoe??th o?iiai-oeeo?a. I?ney e?eoaaiiy Oaeiiii niinoa??aaeanue oaeiae iiceoeaia aeeiai?ea ee?i?/iiai noaio oai?eo: a 9 aeiaaeeao a?aei?/aia ciaioaiiy nooiaith caaeooe, ui c iaea?eueoith a??ia?aei?noth iia'ycaia c iie?ioaiiyi ?aieia?/ieo aeanoeainoae e?ia? oa ciaioaiiyi ca ?aooiie oeueiai eaaaiaai-noaeeiiiai iii?o. ?acthioth/e ?acoeueoaoe aea/aiiy aieeao Oaeiio ia iieacieee cai?oath/i? nenoaie e?ia? o oai?eo ia caoai?thaaiiy eaaaiue a i?iaao in vitro ? a ee?i?/ieo oiiaao iiaeia caeeth/eoe, ui i?aia?ao ia? a?iieiaaoeyoe?ei? oa aioeaa?aaaioi? aeanoeaino?. Io?eiai? ?acoeueoaoe aeathoue i?aenoaao ?aeiiaiaeoaaoe canoinoaaiiy i?aia?aoo Oaeii a eiiieaeniiio e?eoaaii? oai?eo ia caoai?thaaiiy eaaaiue c neiae?iiii a?ia?eiaaoeyoe?? e?ia?. Oaaeeoey 3 - Aeeiai?ea iieaciee?a aaiinoaco o oai?eo c o?ii?/iei eaaaiaaei na?oeai a i?ioean? e?eoaaiiy i?aia?aoii Oaeii (n = 16) IieacieeeA?oia ianoaaeaieo aei e?eoaaiiyA?oia ianoaaeaieo i?ney e?eoaaiiy ?AEA: iA(%) ??O 97.0 1.9 1.74 0.06 91.5 1.2 1.63 0.05 0.05O?iia?iiaee /an10.6 0.511.0 0.5Aoaiieiaee oano: iiceoeaiee neaai iiceoeaiee iaaaoeaiee 2 (12.5 %) 12 (75 %) 2 (12.5 %) - 10 (62.5 %) 6 (37.5 %)?ic/eiiee o?a?ei: +++ ++ + - 2 (12.5 %) 12 (75 %) 2 (12.5 %) - - 8 (50 %) 6 (37.5 %) 2 (12.5 %)Ieaciaiee e?cen140.2 21.6126.4 18.5I?io?iia?iiaee ?iaeaen86.6 1.582.0 1.4O?a?eiiaai4.5 0.23.7 0.2 0.05AAeO-eiaeoeiaaia aa?aaaoe?y o?iiaioeeo?a: a?ia?aa?aaaoe?y 12 (75 %) 7 (43.8 %) AENIIAEE 1. Aenia?eiaioaeueia iiaeaeue caiaeueiiai i?ioeano a eaaaiyo, caniiaaia ia aaaaeaii? ?ii?iaeiiai o?ea a a?iio ca iaoiaeeeith I.A.Caoa?ueaaneie e I.I.Aie/eiaa, noi?iaiaeaeo?oueny ?icaeoeii neiae?iio a?ia?eiaaoeyoe?? e?ia?. 2. Canoinoaaiiy i?aia?aoo Oaeii a aeic? 0,1 a/ea iane o?ea oaa?ei per os ia iiaeae? caiaeueiiai i?ioeano a eaaaiyo aeicaiey? cia/ii ciaioeoe nooi?iue ae?aaeaiino? neiae?iio a?ia?eiaaoeyoe??. 3. O oai?eo ia caoai?thaaiiy eaaaiue c yaeuaie a?ia?eiaaoeyoe?? o?iiaioeeo?a Oaeii in vitro ni?ey? ii?iae?caoe?? aa?aaaoe?eii? caeaoiino? o?iiaioeeo?a a na?aaeiueiio a 80 % aeiaaee?a. 4. Canoinoaaiiy Oaeiio a eiiieaeniiio e?eoaaii? oai?eo ia caoai?thaaiiy eaaaiue, oneeaaeiai? o?ii?/iei eaaaiaaei na?oeai, aeicaiey? ciaioeoe ae?aaeai?noue neiae?iio a?ia?eiaaoeyoe?? e?ia?, i?i ui na?ae/aoue ci?ie iieaciee?a aooieiaaoeyoe?eiiai, aoaiieiaiai oano?a, ai?noo o?a?eiiaaio, ?ic/eiiiai o?a?eio, oanoo c AAeO-?iaeoeiaaiith aa?aaaoe??th o?iiaioeeo?a. 5. Iiceoeaia aeeiai?ea ee?i?/iiai noaio oai?eo a ii?aeiaii? c iie?ioaiiyi iieaciee?a aaiinoaco, a oaeiae a?aenooi?noue iia?/ieo yaeu aeicaieythoue ?aeiiai-aeoaaoe canoinoaaiiy i?aia?aoo Oaeii a eiiieaeniiio e?eoaaii? oai?eo ia caoai?thaaiiy eaaaiue c neiae?iiii a?ia?eiaaoeyoe??th e?ia?. I?AEOE*I? ?AEIIAIAeAOe?? 1. A eiiieaeniiio e?eoaaii? oai?eo ia caoai?thaaiiy eaaaiue, ii?aeiaieie c ?icaeoeii neiae?iio a?ia?eiaaoeyoe?? e?ia?, ?aeiiaiaeo?oueny canoinoaaiiy i?aia?aoo Oaeii a aeic? ii 1,0 a (2 eainoee) per os 4 ?ace ia aeaiue i?ney ?ae?. 2. Aaaaeaiiy ?ii?iaeiiai o?ea a a?iio ca iaoiaeeeith I.A.Caoa?ueaaneie e I.I.Aie/eeia, ii?o/ c ?icaeoeii caiaeueiiai i?ioeano a eaaaiyo o uo??a, aeicaiey? io?eiaoe iiaeaeue neiae?iio a?ia?eiaaoeyoe?? e?ia?. Oey iiaeaeue iiaea aooe aeei?enoaia a iaoeiai-aeine?aeieo ?iaioao ii aea/aiith iiaeo e?ea?nueeeo i?aia?ao?a a?iieiaaoeyoe?eii? ae??. NIENIE ?IA?O, IAAe?OEIAAIEO CA OAIITH AeENA?OAOe?? 1. Iiaaa-3 IIAEE. Iiaue eaea?noaaiiue i?aia?ao Oaeii / TH.E. Oauaiei, A.E. Aaa?enthe, A.E. ss/iee, I.A. Ii?iciaa, N.E. Eauaiei, I.Ae. Ii?neay, O.A. ssoieoea, ss.A. Aecthaeee, A.E. Ei?aeia, O.A. Inaae/oe, E.I. Eaaeai, E.O. E?oaeiaa, I.O.Ianu?iaa.- Eeaa: I?ann-ss?ia?ea, 1996.- 124 n. 2. Canoinoaaiiy iiaiai e?ea?nueeiai i?aia?aoo Oaeii i?e neiae?ii? a?ia?eiaaoeyoe?? e?ia? ia aenia?eiaioaeuei?e iiaeae? caiaeueiiai i?ioeano eaaai?a / TH.?. Oauaiei, A.E. Aaa?enthe, A.?. ss/iee, I.A. Ii?iciaa, A.?. Ei?aeia, O.A. Inaae-/oe, A.I. Aeouei?ia, N.?. Eauaiei // E?ee.- 1995.- N 5.- N. 98-102 3. Ii?iciaa I.A., Eauaiei N.E. Aeeyiea i?aia?aoa Oaeii ia aa?aaaoeeiiioth niiniaiinoue o?iiaioeeoia in vitro o aieueiuo n o?iie/aneei eaai/iui na?aeoeai // Oe?a?inueeee ea?ae?ieia?/iee aeo?iae.- 1996.- N 3.- N. 189. 4. A?iie?iie?i?aeai?/ia, a?iieiaaoeyoe?eia oa aioeaa?aaaioia ae?y iiaiai e?ea?nueeiai i?aia?aoa Oaeii a aenia?eiaio? / TH.?. Oauaiei, A.E. Aaa?enthe, A.?. Ei?aeia, I.A. Ii?iciaa, A.?. ss/iee, N.?. Eauaiei, O.A. 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A ?iaio? iaaaaeaia aea/aiiy aieeao ia iieacieee aaiinoaco i?e caoai?thaaiiyo eaaaiue iiaiai e?ea?nueeiai i?aia?aoo Oaeii, yeee i?aaenoaaey? niaith noi?o c aenieei ai?noii iiaaa-3 iie?iaiane/aieo aee?ieo eeneio. Aeine?aeaeaiiy i?iaaaeai? ia aenia?eiaioaeuei?e iiaeae? caiaeueiiai i?ioeano a eaaaiyo, a i?iaao in vitro ? a ee?i?/ieo oiiaao. A ?acoeueoao? anoaiiaeaia a?iieiaaoeyoe?eia oa aioeaa?aaaioia ae?y Oaeiio, ui aeicaiey? ?aeiiaiaeoaaoe eiai canoinoaaiiy a eiiieaeniiio e?eoaaii? oai?eo ia caoai?thaaiiy eaaaiue c neiae?iiii a?ia?eiaaoeyoe?? e?ia?. Eeth/ia? neiaa: caoai?thaaiiy eaaaiue, neiae?ii a?ia?eiaaoeyoe??, iiaaa-3 iie?iaiane/ai? aee?i? eeneioe, Oaeii. Naeaciaiei O.O. Yooaeoeaiinoue i?aia?aoa Oaeii a ei??aeoeee nenoaiu aaiinoaca i?e caaieaaaieyo eaaeeo.- ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.27 - ioeueiiiieiaey.- Einoeooo ooeceao?ee e ioeueiiiieiaee ei. O.A.ssiianeiai AII Oe?aeiu, Eeaa, 1998. A ?aaioa i?aaenoaaeaiu ?acoeueoaou eco/aiey aeeyiey ia iieacaoaee aaiinoaca i?e caaieaaaieyo eaaeeo iiaiai eaea?noaaiiiai i?aia?aoa Oaeii, i?aaenoaaeythuaai niaie nianue n aunieei niaea?aeaieai iiaaa-3 iieeiaianuuaiiuo aee?iuo eeneio. Enneaaeiaaiey i?iaaaeaiu a yenia?eiaioaeueiie iiaeaee ainiaeeoaeueiiai i?ioeanna a eaaeeo, a i?iaao in vitro e a eeeie/aneeo oneiaeyo. A ?acoeueoaoa onoaiiaeaii aeiieiaaoeyoeeiiiia e aioeaa?aaaioiia aeaenoaea Oaeiia, /oi iicaieyao ?aeiiaiaeiaaoue aai i?eiaiaiea a eiiieaeniii ea/aiee aieueiuo caaieaaaieyie eaaeeo n neiae?iiii aeia?eiaaoeyoeee e?iae. Eeth/aaua neiaa: caaieaaaiey eaaeeo, neiae?ii aeia?eiaaoeyoeee, iiaaa-3 iieeiaianuuaiiua aee?iua eeneiou, Oaeii. Seleznenko T.F. Effectiveness of medication Tecom in correction of hemostasis in lung diseases. – Manuscript. Dissertation is to be submitted for a degree of Candidate of Medical Sciences in 14.01.27 specialty – pulmonology. Institute of Phthysiatry and Pulmonology named after F.G. Yanovsky of Medical Sciences Academy, Kyiv, 1998. The influence of new medication Tecom being a combination of high concentrated omega-3 polyunsaturated fatty acids on the hemostasis parameters in lung diseases was investigated. The investigation was performed in experimental model of inflammation in lungs, in tests in vitro and in clinic. As a result it has been determined that Tecom has hypocoagulative and antiaggregative activity and may be recommended for complex treatment of patients with lung diseases with syndrome of hypercoagulation of blood. Key words: lung diseases, syndrome of hypercoagulation, omega-3 polyunsaturated fatty acids, Tecom.

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