I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

EUeA?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

?i. AeAIEEA AAEEOeUeEIAI

ssAI?NUeEA Ienaia Iao??aia

OAeE:
615.3:(546.47+547.7892).07.014].002.

Aeine?aeaeaiiy

oaeaoii? niieoee oeeieo c 2-ia?eaioiaaico?acieii

oa ?ic?iaea e?ea?nueeeo oi?i ia ?? iniia?

15.00.01 – oaoiieia?y e?e?a oa i?iieneiaa oa?iaoe?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa oa?iaoeaaoe/ieo iaoe

Euea?a – 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia ia eaoaae?? caaaeueii?, a?iiai?aai?/ii? oa o?ceiei?aeii?
o?i?? Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea
Aaeeoeueeiai.

Iaoeia? ea??aieee: aeieoi? oa?iaoeaaoe/ieo iaoe, i?ioani?

Ieiea Aiaoie?e Oaaei?iae/

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai,
caa?aeoaa/ eaoaae?e caaaeueii?, a?iiai?aai?/ii? oa o?ceiei?aeii? o?i??;

eaiaeeaeao oa?iaoeaaoe/ieo iaoe, aeioeaio

Ca?oia Ethaia ?aaai?aia

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea Aaeeoeueeiai,
aeioeaio eaoaae?e oaoiieia?? e?e?a c eo?nii caaiaenueei? oaoiieia??
e?e?a.

Io?oe?ei? iiiiaioe: aeieoi? oa?iaoeaaoe/ieo iaoe, i?ioani?

Aieiae?i A’y/aneaa Ieaenaiae?iae/

Caii??cueeee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e oaoiieia??
e?e?a;

aeieoi? oa?iaoeaaoe/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee

*a?iae Ieaenaiae? Iaoiae?eiae/

Euea?anueeee iaoeiai-aeine?aeiee ?inoeooo iaoieia?? e?ia? oa
o?ainooc?eii? iaaeeoeeie IIC Oe?a?ie, caa?aeoaa/ eaai?aoi??? a?io?i??
e?ia?.

I?ia?aeia i?aai?caoe?y: Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y (i.
Oa?e?a),

eaoaae?a aioa/ii? oaoiieia?? e?e?a.

Caoeno a?aeaoaeaoueny ______________ 1998 ?. i ____ aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 35.600.02 o Euea?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i. Aeaieea Aaeeoeueeiai ca
aae?anith: 290000, INI, i. Euea?a, aoe. Iaea?nueea, 69.

C aeena?oaoe??th iiaeia iciaeiieoenue o iaoeia?e a?ae?ioaoe?
oi?aa?neoaoo (290000, i. Euea?a, aoe. N?/iaeo No??eueoe?a, 6).

Aaoi?aoa?ao ?ic?neaiee ________________ 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee E 35.600.02

aeioeaio Aanthe
A.Ae.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ??aaiue aeeooy oa noai caei?ia’y ianaeaiiy a
cia/i?e i??? iia’ycai? c ?icaeoeii aaoa?eia?ii? iaaeeoeeie.

Iio?aae ia?iaeiiai ainiiaea?noaa coiiaeee aeieeiaiiy oa no??ieee
?icaeoie ie?aiiai iai?yieo oa?iaoeaaoe/ii? iaoee – aaoa?eia?ii?
oa?iaoe??. I?iaeoeoeai?noue a?o/eciyiiai oaa?eiieoeoaa ciaoiaeeoueny o
i?yi?e caeaaeiino? a?ae eiiieaeno caoiae?a, ni?yiiaaieo ia i?io?eaeoeeo
oa e?eoaaiiy caoai?thaaiue oaa?ei. Iaei??th c i?e/ei aaeeeeo aeiiii?/ieo
caeoe?a o aaeoc? ? c?inoaiiy iaie?aeiino? oaa?ei, ni?e/eiaii? ??cieie
a?iaeieia?/ieie caoai?thaaiiyie, cie?aia aiaeiiao?eoii aaeoa??aeueii? oa
a?eaeiai? ao?ieia??.

A?eueo?noue ?nioth/eo a?o/eciyieo aaoa?eia?ieo cania?a aeey e?eoaaiiy
aiaeiiao?eoo ia a?aeiia?aeathoue no/aniei aeiiaai c iaeyaeo
oa?aiaaoe/ii? aoaeoeaiino? oa aeiiii?/ieo iieaciee?a. Oiio aeooaeueiith
i?iaeaiith ? iiooe iiaeo a?ieia?/ii aeoeaieo ?a/iaei ?c oe?ieei niaeo?ii
i?ioea?eaeiai? oa i?ioei?e?iaii? ae?? ? noai?aiiy ia ?o iniia?
?aoe?iiaeueieo e?ea?nueeeo oi?i c iaoith canoinoaaiiy o aaoa?eia?i?e
i?aeoeoe?. Iaea?eueo ?aoe?iiaeueieie ?a/iaeiaie cacia/aiiai niaeo?o ae??
? iio?aei? 2-ia?eaioiaaico?acieo c iaeyaeo ia ?o iaeo oiene/i?noue ?
aenieo aeiiii?/io aeinooii?noue.

I?aoe? I.Ae.Eeoaei/oea (1965), A.I.E?oiae?aea (1975), A.A. Aeaaeeoaaa
(1988), ?.I.Iooaeuenueei? (1994), A.A.Aieiae?ia (1997) oa aeaye? ?io?,
i?enay/ai? aea/aiith oa?iaeieia?/ieo, oieneeieia?/ieo, i?e?ia?ieia?/ieo
oa oaoiieia?/ieo aeanoeainoae e?ea?nueeeo cania?a ia iniia?
2-ia?eaioiaaico?acieo. O ca’yceo c oeei, neioac oa aea/aiiy aeanoeainoae
iiaeo a?ieia?/ii aeoeaieo ?a/iaei, iio?aeieo 2-ia?eaioiaaico?acieo, ?
aeooaeueiei ? ia?niaeoeaiei.

Oeeieia? nie? 2-ia?eaioiaaico?acieo caneoaiaothoue ia iniaeeao oaaao c
iaeyaeo ia ?o aaaeeeao ?ieue a iai?iieo i?ioeanao i?aai?cio, ui
aeei?enoiao?oueny aeey i?eaiooaaiiy cania?a eieaeueii? ae??, i?ecia/aieo
aeey e?eoaaiiy caoai?thaaiue oe??e ? neeciaeo ??cii? ao?ieia??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa aeeiiaia o a?aeiia?aeiino? c ieaiii i?iaeaie „Oa?iaoe?y” IIC
Oe?a?ie ? ? o?aaiaioii eiiieaenii? iaoeiai-aeine?aeii? ?iaioe
Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (? aea?ae?a?no?aoe??
01.91.00.19.91.6, oeo? oaie ?I 10.06.0001.91).

Iaoa oa caaaeaiiy aeine?aeaeaiiy. Iaoith ?iaioe aoei io?eiaiiy
eiiieaenii? nie? oeeieo c 2-ia?eaioiaaico?acieii, aeine?aeaeaiiy ??
a?ieia?/ii? aeoeaiino?, iaoeiaa iaa?oiooaaiiy neeaaeo oa ii?aoethaaiiy
oaoiieia?? e?ea?nueeeo oi?i c aeacaiith ?a/iaeiith aeey aaoa?eia???.

Aeey aeinyaiaiiy iinoaaeaii? iaoe iaiao?aeii aoei ae??oeoe oae?
caaaeaiiy:

– ii?aoethaaoe niin?a iaea?aeaiiy oeeieiai? nie? 2-ia?eaioiaaico?acieo
oa aeine?aeeoe ?? o?ceei-o?i?/i? aeanoeaino?;

– ?ic?iaeoe iaoiaeeee ye?niiai oa e?euee?niiai aiae?co oeeieiai? nie?
2-ia?eaioiaaico?acieo ye noanoaioe??;

– aeine?aeeoe oiene/i?noue oa i?noeaaiiiae?acithaaeueio ae?th oeeieiai?
nie? 2-ia?eaioiaaico?acieo;

– anoaiiaeoe niaeo? i?ioei?e?iaii? oa i?ioea?eaeiai? aeoeaiino?
oeeieiai? nie? 2-ia?eaioiaaico?acieo;

– ii?aoethaaoe iioeiaeueiee neeaae oa ?aoe?iiaeueio oaoiieia?th
noniaic?? oa aaa?iaeueieo iaee/ie ?c oeeieiaith n?eeth
2-ia?eaioiaaico?acieo, i?eaeaoieo aeey e?eoaaiiy oaa?ei;

– ii?aoethaaoe iaoiaeeee ye?niiai oa e?euee?niiai aecia/aiiy oeeieiai?
nie? 2-ia?eaioiaaico?acieo o e?ea?nueeeo oi?iao;

– i?iaanoe i?e?ia?ieia?/i? aeine?aeaeaiiy cai?iiiiiaaieo e?ea?nueeeo
oi?i;

– anoaiiaeoe oa?i?ie i?eaeaoiino? ii?aoeueiaaieo e?ea?nueeeo oi?i ia
iniia? aeine?aeaeaiiy ?o o?ceei-o?i?/ieo aeanoeainoae, ci?ie ai?noo
ae?th/i? ?a/iaeie o i?ioean? caa??aaiiy, niaoeeo?/ii? aeoeaiino?;

– anoaiiaeoe a?ieia?/io aeinooii?noue oeeieiai? nie?
2-ia?eaioiaaico?acieo o aaa?iaeueieo noiiceoi??yo o aeine?aeao in vivo;

– aea/eoe oa?iaeieia?/i? aeanoeaino? cai?iiiiiaaieo cania?a caoenoo
oaa?ei;

– ii?aoethaaoe ii?iaoeaii-oaoi?/io aeieoiaioaoe?th ia noniaic?th oa
aaa?iaeuei? iaee/ee ?c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo aeey
canoinoaaiiy o aaoa?eia???.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa i?iaaaeaii eiiieaenia
o?ceei-o?i?/ia, i?e?ia?ieia?/ia, oieneeieia?/ia, oaoiieia?/ia oa
oa?iaeieia?/ia aeine?aeaeaiiy oeeieiai? nie? 2-ia?eaioiaaico?acieo.

Cai?iiiiiaaii iioeiaeueiee neeaae, oaoiieia?th oa iaoiaeeee aiae?co
e?ea?nueeeo oi?i: noniaic?? oa aaa?iaeueieo iaee/ie, ui i?noyoue ye
iniiaio ae?th/o ?a/iaeio oeeieiao n?eue 2-ia?eaioiaaico?acieo.
Anoaiiaeaii niaeo? niaoeeo?/ii? aeoeaiino? oa oa?i?ie i?eaeaoiino?
ii?aoeueiaaieo cania?a caoenoo oaa?ei.

Neeaaeaii ii?iaoeaii-oaoi?/io aeieoiaioaoe?th ia noniaic?th oa
aaa?iaeuei? iaee/ee ?c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo aeey
canoinoaaiiy o aaoa?eia???.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Ai?iaaaeaeai? o i?aeoeeo
aaoa?eia??? OO 46.15.086–95 ia noniaic?th „Ia?eaioiae?iaen” (aeo
ai?iaaaeaeaiiy a?ae 07.11.1997?.) oa OO O 46 15.206.97 ia „Noiiceoi???
Ia?eaaai” (aeo ai?iaaaeaeaiiy a?ae 18.07.1998?.). Caoaa?aeaeai?
Aea?aeaaiei aeaia?oaiaioii aaoa?eia?ii? iaaeeoeeie I?i?noa?noaa
aa?ii?iieneiaiai eiiieaeno Oe?a?ie Ianoaiiaa ii canoinoaaiith noniaic??
„Ia?eaioiae?iaen” aeey e?eoaaiiy aea?iaoieia?/ieo caoai?thaaiue nnaaoe?a
(1995?.) oa Ianoaiiaa ii canoinoaaiith noiiceoi???a „Ia?eaaai” (a?ae
04.03.1997?., ?15-14/77).

Iniaenoee aianie caeiaoaa/a:

– cae?eniaii iiooe oa aiae?c aeaieo e?oa?aoo?e;

– ii?aoeueiaaii niin?a iaea?aeaiiy oeeieiai? nie? 2-ia?eaioiaaico?acieo
oa aea/aii ?? o?ceei–o?i?/i? aeanoeaino?;

– ?ic?iaeaii iaoiaeeee ye?niiai oa e?euee?niiai aiae?co oeeieiai? nie?
2-ia?eaioiaaico?acieo ye noanoaioe??;

– ii?aoeueiaaii neeaae ? oaoiieia?th noniaic?? oa aaa?iaeueieo iaee/ie
?c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo;

– ?ic?iaeaii iaoiaeeee ye?niiai oa e?euee?niiai aecia/aiiy ae?th/i?
?a/iaeie a ii?aoeueiaaieo e?ea?nueeeo oi?iao;

– anoaiiaeaii oa?i?ie i?eaeaoiino? cai?iiiiiaaieo e?ea?nueeeo oi?i;

– aea/aii a?ieia?/io aeinooii?noue oeeieiai? nie? 2-ia?eaioiaaico?acieo
c aaa?iaeueieo iaee/ie o aeine?aeao in vivo;

– neeaaeaii oaoi?/i? oiiae ia noniaic?th „Ia?eaioiae?iaen” aeey
canoinoaaiiy o aaoa?eia?i?e iaaeeoeei?;

– neeaaeaii oaoi?/i? oiiae ia aaa?iaeuei? iaee/ee „Ia?eaaai” aeey
canoinoaaiiy o aaoa?eia?i?e iaaeeoeei?.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe?eii?
?iaioe aeiiia?aeaeenue ia ?-io Eiia?an? Na?oiai? Oaaea?aoe??
oe?a?inueeeo oa?iaoeaaoe/ieo oiaa?enoa (Euea?a, 1994);
iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 20-??//th canioaaiiy
Aea?aeaaii? iaoeiai-aeine?aeii? eiio?ieueii? onoaiiae aaoa?eia?ieo
i?aia?ao?a ? ei?iiaeo aeiaaaie a Oe?a?i? (Euea?a, 1996); ???-o?e
I?aeia?iaei?e iaoeiai-i?aeoe/i?e eiioa?aioe?? „I?iaeaie aaoa?eia?iiai
ianeoaiaoaaiiy ae??aieo aeiiaoi?o oaa?ei” (Ee?a, 1998); IV-io
?a?iiaenueeiio eiia?an? c oa?iaoeaaoe/ieo aeenoeeie?i (I?eai, ?oae?y,
1998); can?aeaii? eaoaae?e caaaeueii?, a?iiai?aai?/ii? oa o?ceiei?aeii?
o?i?? Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea
Aaeeoeueeiai (Euea?a, 1998).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 13 ?ia?o, o oiio
/ene? 4 noaoo? o aeo?iaeao, 7 o ca??ieeao iaoeiaeo i?aoeue, 2 oacao
aeiiia?aeae.

No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 171
noi??ioe? iaoeiiieno (a oiio /ene? 121 noi??iie oaenoo), neeaaea?oueny
?c anooio, iaeyaeo e?oa?aoo?e, 4-io ?icae?e?a aenia?eiaioaeueieo
aeine?aeaeaiue, aeniiae?a, nieneo e?oa?aoo?e, yeee aeeth/a? 168
aeaea?ae, o oiio /ene? 55 ca?oa?aeieo aaoi??a oa 6 aeiaeaoe?a.

?iaioa ?ethno?iaaia 27 oaaeeoeyie (15 noi??iie) ? 12 ?enoieaie (9
noi??iie).

INIIAI? ?ACOEUeOAOE AeENA?OAOe?EII? ?IAIOE

Niiniae iaea?aeaiiy oa iaoiaee aiae?co oeeieiai? nie?

2-ia?eaioiaaico?acieo

Aeo?aeieie ?a/iaeiaie aeey neioaco oeeieiai? nie? 2-ia?eaioiaaico?acieo
aoee oaoi?/iee 2-ia?eaioiaaico?acie, yeee iiia?aaeiuei
ia?ae?enoae?ciaoaaee ?c noi?oae aoaiie-aiaea i/euaia (4:3) aai
aoeaoii-aiaea i/euaia (2:1), iao??th a?ae?ieneae oa oeeieo noeueoao.
?aaeoe?y a?aeaoaaeany o nie?oiai-aiaeiiio na?aaeiaeu? ca noaiith:

Neioaciaaia n?eue – na?oeiaeiaoee aii?oiee ii?ioie c aenieith
caeaoi?noth aei ieeiooai?aiiy, Ooiie=296(N, ia?ic/eiia o aiae?, nie?o?,
?ic/eiia o aeeiaoeenoeueoieneae? (AeINI), ?ic/eiao eoa?a, oei?ioi?i?,
i?e iaa??aaii? – o ia?neeia?e oa ieeaeia?e ie?yo. Aeey i?aeoaa?aeaeaiiy
no?oeoo?e io?eiaii? niieoee, aea/aee niaeo?e II? nie? oa aeo?aeii?
?a/iaeie – 2-ia?eaioiaaico?acieo (?ic/eiiee – AeINI, i?eeaae Gemini-300,
o?i?/i? ci?uaiiy iiaeaii o i. /. a?aeiinii oao?aiaoeeneeaio).
Niaeo?aeuei? oa?aeoa?enoeee ?a/iaei iaaaaeai? o oaae. 1.

Aeey ye?niiai aiae?co oeeieiai? nie? 2-ia?eaioiaaico?acieo i?iaiaeeee
?aaeoe?? c eueiaeiaith aoeaoaoiith eeneioith oa oa?ioe?ai?aeii (??)
eae?th. E?euee?nia aecia/aiiy i?iaiaeeee iaoiaeii cai?ioiiai
eiiieaeniiiiao?e/iiai oeo?oaaiiy (a?aeiinia iioeaea aecia/aiue 1,96%) oa
iaoiaeii iiey?ia?ao?? (a?aeiinia iioeaea aecia/aiue 2,14%).

Oaaeeoey 1

Oa?aeoa?enoeee niaeo??a II? 2-ia?eaioiaaico?acieo

oa eiai oeeieiai? nie?

7,13o, J=7,5Aoe, 7,24o, 7,62ae, J=8,1 Aoe (8I; 2(N6I4)

Iaa?oiooaaiiy neeaaeo ? oaoiieia?? e?ea?nueeeo oi?i

c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo

Noniaic?y ia iniia? oeeieiai? nie? 2-ia?eaioiaaico?acieo

Ca ?acoeueoaoaie i?e?ia?ieia?/iiai aeine?aeaeaiiy oeeieiai? nie?
2-ia?eaioiaaico?acieo anoaiiaeaii oe?ieee niaeo? ?? ooia?oeeaeii? oa
aioei?e?iaii? ae??. Oiio iaie ii?aoeueiaaii neeaae ? oaoiieia?th
noniaic?? c aeine?aeaeoaaiith a?ieia?/ii aeoeaiith ?a/iaeiith,
i?eaeaoii? aeey ciai?oiueiai canoinoaaiiy a aea?iaoieia?/i?e i?aeoeoe? o
oaa?ei. Aeey i?eaiooaaiiy aoaeoeaiiai i?ioea?eaeiaiai caniao aaaeeeaa
cia/aiiy ia? iaea?aeaiiy oiieiaeenia?niiai inaaeo. Iaea?aeaiiy noniaic??
iaoiaeii o?i?/ii? eiiaeainaoe?? caaacia/o? aenieee nooi?iue
aeenia?niino? /anoeiie oeeieiai? nie? 2-ia?eaioiaaico?acieo, yeee a
naith /a?ao, aieeaa? ia noaa?euei?noue e?ea?nueeiai caniao. Oeeieiaa
n?eue 2-ia?eaioiaaico?acieo, yea ooai?th?oueny aiane?aeie o?i?/ii?
aca?iiae?? a?ae?io?e?co?oueny eiiiiiaioaie, ui aoiaeyoue aei neeaaeo
noniaic??, a naia: nie?oii aoeeiaei, ae?oea?eiii ? aeeiaeneaeii.
Inoaii?e caaacia/o? oaeiae i?iieeiaiiy a?ieia?/ii aeoeaii? ?a/iaeie aei
aeeaeiieo oa??a oe??e, ui aaaeeeai i?e aea?iaoii?eicao. Ae?oea?ei
iaiao?aeiee aeey noai?aiiy iioeiaeueii? a’yceino? aeenia?n?eiiai
na?aaeiaeua, yea aieeaa? ia e?iaoe/io noaa?euei?noue noniaic?? a
i?ioean? caa??aaiiy. Neeaae noniaic?? (o %): oeeieiaa n?eue
2-ia?eaioiaaico?acieo 5,0; nie?o aoeeiaee 30,0; ae?oea?ei 20,0;
aeeiaeneae 5,0; aiaea i/euaia 40,0. Noniaic?th iaea?aeoaaee oeyoii
ceeaaiiy iiia?aaeiuei i?eaioiaaieo ?ic/ei?a iao???ai? nie?
2-ia?eaioiaaico?acieo oa oeeieo noeueoaoo. Aiane?aeie o?i?/ii?
aca?iiae?? (?aaeoe?? iai?io) ooai?thaaany oiieiaeenia?niee inaae
oeeieiai? nie? 2-ia?eaioiaaico?acieo. Iaea?aeaiee can?a eaaei
?anoniaiaeo?oueny, ui caaacia/o? ??aiii??i?noue iaianaiiy eiai ia
o?aaeaio iiaa?oith oe??e. C iaoith noaiaea?oecaoe?? e?ea?nueei? oi?ie,
ii?aoeueiaaii iaoiaeeeo ioe?iee yeino?, yea aeeth/a? aecia/aiiy
i?aaiieaioe/ieo oa?aeoa?enoee, oioiaeiino? oa e?euee?niiai ai?noo
ae?th/i? ?a/iaeie. Aeey i?iaaaeaiiy e?euee?niiai aecia/aiiy
iiaeeo?eoaaee iaoiaeeee cai?ioiiai eiiieaeniiiiao?e/iiai oeo?oaaiiy oa
iiey?ia?ao??, ye? aoee iiia?aaeiuei ii?aoeueiaai? aeey noanoaioe??.
A?aeiini? iioeaee aecia/aiue noaiiaeyoue a?aeiia?aeii 3,43 oa 4,27 %.
Aeey anoaiiaeaiiy iiaiioe i?ioiaeaeaiiy o?i?/ii? ?aaeoe?? o i?ioean?
io?eiaiiy noniaic?? ciaoiaeeee ianiao /anoeo iaca’ycaiiai oeeieo
iaoiaeii iiey?ia?ao??. Ca i?aaii-eaioe/ieie oa o?ceei-o?i?/ieie
iieacieeaie noaiaea?oeciaaia noniaic?y a?aeiia?aea? iaiao?aeiei aeiiaai
(oaae. 2).

Oaaeeoey 2

I?aaiieaioe/i? oa o?ceei-o?i?/i? iieacieee yeino? noniaic??

Iacaa iieacieea Cia/aiiy

I?aaiieaioe/i? oa?aeoa?enoeee Aonoa noniaic?y a?eiai aai neaaiaeiaoiai
eieuei?o, iaeii??aeii? eiinenoaioe??, aeia?a ?anoniaiaeo?oueny

?ici??e /anoeiie oeeieiai? nie? 2-ia?eai-oiaaico?acieo 0,9–1,0 iei

?aeaioe/i?noue oeeieiai? nie? 2-ia?eai-oiaaico?acieo (ye?ni? ?aaeoe??)
Iiceoeaia

Ianiaa /anoea a?eueiiai oeeieo ia 100 a noniaic??, a 0,02–0,04

Ianiaa /anoea ae?th/i? ?a/iaeie ia 100 a noniaic??, a 4,5–5,2

Anoaiiaeaii, ui o?ceei-o?i?/i? iieacieee yeino? oa niaeo? aioei?e?iaii?
aeoeaiino? aeey ii?aoeueiaaii? noniaic?? i?ioyaii 15 i?nyoe?a
caeeoathoueny i?aeoe/ii iaci?iieie.

Aaa?iaeuei? e?ea?nuee? oi?ie c oeeieiaith n?eeth

2-ia?eaioiaaico?acieo

C iaeyaeo ia aiaoiii-ii?oieia?/i? iniaeeaino? aoaeiae noaoaaeo i?aai?a o
oaa?ei (cie?aia ei??a), aeaieo e?oa?aoo?e oa ca ocaiaeaeaiiyi c
aaoa?eia?ieie e?ea?yie, ye e?ea?nueeo oi?io ie aea?aee aaa?iaeuei?
iaee/ee. E?euee?noue ae?th/i? ?a/iaeie – oeeieiai? nie?
2-ia?eaioiaaico?acieo (0,75a) – ia iaeio iaee/eo caaaeueiith ianith (10
( 0,2) a, aoea anoaiiaeaia aenia?eiaioaeueii, aa?o/e ca iniiao
?acoeueoaoe i?e?ia?ieia?/ieo ? oa?iaeieia?/ieo aeine?aeaeaiue,
aoaeoeai?noue oa o?eaae?noue e?eoaaiiy oaa?ei, a?aenooi?noue
?aoeeaeea?a. Iaea?eueo ?aoe?iiaeueii aiooaaoe noiiceoi??? (iaee/ee) aeey
aaoa?eia?ii? i?aeoeee ia aeinooiieo iie?eiiiiiaioieo iniiaao
e?iio?eueii? oa a?ae?io?eueii? i?e?iaee.

Neeaae eiiiiiaio?a ia iaeio iaee/eo: oeeieiai? nie?
2-ia?eaioiaaico?acieo 0,75; aeeiaeneaeo 0,5; iniiae aei 10,0. Neeaae
e?ii-o?eueii? iniiae (a %): ia?ao?io oaa?aeiai 10,0; naeiiano 60,0;
ianea eaeai 30,0. Aeey cai?iiiiiaaii? iniiae aecia/aee: Ooiie=35,92(N,
/an iiaii? aeaoi?iaoe?? 169,8 n, cia/aiiy eeneioiiai /enea 1,99,
cia/aiiy ?I=6,81. Iaee/ee aiooaaee iaoiaeaie aeea/oaaiiy oa aeeeaaiiy
(eiao?oe??io cai?uaiiy nie? aeey cai?iiiiiaaii? iniiae 0,78). Aea/aee
aieea ae?th/i? ?a/iaeie ia o?ceei-o?i?/i? oa no?oeoo?ii-iaoai?/i?
iieacieee iaee/ie ia e?iio?euei?e iniia?: Ooiie=36,72(N, /an iiaii?
aeaoi?iaoe?? – 147,8 n, cia/aiiy ?I=5,84. Oeeieiaa n?eue ciaioo? /an
iiaii? aeaoi?iaoe??, ui iiynith?oueny ci?iaie o no?oeoo?iaaiino? nenoaie
? i?aeoaa?aeaeo?oueny ?aieia?/ieie oa?aeoa?enoeeaie.

Aeey ianiaiai i?eaiooaaiiy aaoa?eia?ii? aaa?iaeueii? e?ea?nueei? oi?ie
aee?e ia ?aeiiaiaeothoueny /a?ac ?o iano?ee?noue. A?ae?ioiai? iniiae
??aeei aeei?enoiaothoue aeey aaa?iaeueieo noiiceoi???a /e iaee/ie, oiio
ui aiie ooai?ththoue iaaniieooaai? oi?ie (oaeaeea ieaaeaiiy ?
aeo?eaiiy). Oe? iaaaoeai? aeanoeaino? onoaathoueny i?e aeei?enoaii?
a?ae?io?eueieo iniia. Iae/ano?oa aeey i?eaiooaaiiy aaa?iaeueieo
e?ea?nueeeo oi?i aeei?enoiaothoue aeaeaoeii-ae?oea?eiiao oa IAI-iniiae.
Inoaii? aeyaeeenue iai?eaeaoieie aeey i?eaiooaaiiy iaee/ie, ine?eueee
nai? iie?aoeeaiieneaee aca?iiae?thoue ?c ae?th/ith ?a/iaeiith (ci?ia
caaa?aeaiiy noiiceoi?ii? iniiae o i?ioean? caa??aaiiy, ??cea ci?ia
cia/aiiy ?I noiiceoi???a oaea i?ioyaii 1-ai i?nyoey caa??aaiiy).
AEaeaoeii-ae?oea?eiiaa iniiaa oa?aeoa?eco?oueny: iia?eueiei ?ic/eiaiiyi
o nae?aoao neeciaeo, iinooiiaei aea?eueiaiiyi e?ea?nueeeo ?a/iaei ?
i?ieiiaoaaiiyi ?o ae??. Niaoeeo?ea aeaieo iaee/ie ye e?ea?nueei? oi?ie,
i?ecia/aii? aeey canoinoaaiy o aaoa?eia?i?e i?aeoeoe?, aeiaaaea
iiaeeo?eoaaoe neeaae io?oeeiaeueii? aeaeaoeii-ae?oea?eiiai? iniiae, c
iaoith ca?eueoaiiy i?oaeieo aeanoeainoae iaee/ie, ui caaacia/oaaei a
iaeneiaeueio c?o/i?noue i?e aeei?enoaii? e?ea?nueei? oi?ie.
Aeia?eiaioaeueiei oeyoii anoaiiaeaii, ui iaec?o/i?oeie o aeei?enoaii? ?
iaee/ee ia aeaeaoeii-ae?oea?eiia?e iniia? ianooiiiai neeaaeo (a
/anoeiao): aeaeaoeia iaaee/ia 2,0; ae?oea?ei 5,7; aiaea i/euaia 2,3.
Cai?iiiii-aaiee neeaae iniiae ca oa?aeoa?enoe/ieie iieacieeaie
a?aeiia?aea? iaiao?aeiei aeiiaai: /an ?ic/eiaiiy 50,3 oa, cia/aiiy
?I=6,20. Aeine?aeaeoaaee aieea oeeieiai? nie? 2-ia?eaioiaaico?acieo ia
oaoiieia?/i? ? o?ceei-o?i?/i? iieacieee a?ae?io?eueieo iaee/ie: /an
?ic/eiaiiy 29,98 oa, cia/aiiy ?I=5,81. C iaoith ii??aiyiiy ieanoe/ieo
aeanoeainoae aeaeaoeii-ae?oea?eiiai? iniiae io?oeeiaeueiiai oa
iaio?oeeiaeueiiai neeaaeo, a oaeiae anoaiiaeaiiy iiaeeeaiai aieeao
ae?th/i? ?a/iaeie ia no?oeoo?ii-iaoai?/i? aeanoeaino? iniia
aeei?enoiaoaaee i?eeaae „Oaici Oano”. Aei??thaaee neeo ?ic?eao
aeaeaoeii-ae?oea?eiiaeo ieanoeiie (aeiaaeeia – 8,0 ni, oe?eia – 4,0 ni,
aenioa – 0,5 ni), oiaoi aaee/eio cciai? i?eeeaaeaii? neee i?e ye?e
ieanoeiea, i?aeaeath/enue nii/aoeo iaeneiaeuei?e aeaoi?iaoe??,
?ic?eaa?oueny. ?acoeueoaoe aeine?aeaeaiue i?aaenoaaeai? ia ?en. 1.

?en. 1. ?acoeueoaoe aeine?aeaeaiiy ieanoe/ieo aeanoeainoae ieanoeiie ia
aeaeaoeii-ae?oea?eiiaeo iniiaao:

1– io?oeeiaeueia aeaeaoeii-ae?oea?eiiaa iniiaa;

2– noiiceoi?ia iana ?c oeeieiaith n?eeth 2-ia?eaioiaaico?acieii ia
iniia? 1;

3– iaio?oeeiaeueia (cai?iiiiiaaia) aeaeaoeii-ae?oea?eiiaa iniiaa;

4– noiiceoi?ia iana ?c oeeieiaith n?eeth 2-iaeaioiaaico?acieo ia iniia?
3.

Anoaiiaeaii, ui o?ceei-o?i?/i? iieacieee yeino? oa niaeo? aioei?e?iaii?
aeoeaiino? aeey ii?aoeueiaaieo a?ae?io?eueieo iaee/ie caeeoathoueny
i?aeoe/ii iaci?iieie i?ioyaii 18 i?nyoe?a. Oiio o OO ia iaee/ee
„Ia?eaaai” cacia/aiee iieaciee „Oa?i?i i?eaeaoiino?” 18 i?nyoe?a i?e
oaiia?aoo?? 25(N.

I?e?ia?ieia?/ia aeine?aeaeaiiy oeeieiai? nie?

oa ii?aoeueiaaieo ia ?? iniia? e?ea?nueeeo oi?i

Aeine?aeaeaiiy i?iaiaeeee ia eaoaae?? i?e?ia?ieia?? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai. Ia iniia?
i?e?ia?ieia?/ieo aeine?aeaeaiue anoaiiaeaii, ui ca aaee/eiith cii
cao?eiee ?inoo iaoiaaiieo a?ea?a ? aaeoa??e oeeieiaa n?eue
2-ia?eaioiaaico?acieo ia? noaoenoe/ii aeinoia??io ia?aaaao ia?aae
2-ia?eaioiaaico?acieii. Aeine?aeaeoaai? i?e?ii?aai?cie a?aeiinyoueny aei
aeae?a, ye? oaeaeei i?enoiniaothoueny aei ae?? aioei?e?iaieo cania?a ?
na?aae aeae?eaieo i?e ae?aaiinoe/ieo aeine?aeaeaiiyo ooai?a,
cono??/a?oueny aaeeeee a?aenioie oi?i, ?acenoaioieo aei aioea?ioeei- oa
o?i?ii?aia?ao?a, ui coiiaeth? iio?aao a ?o iino?eiiio iiiiaeaii?.

Aioei?e?iaia ae?y aaa?iaeueieo e?ea?nueeeo oi?i aea/aeanue ia
noaiaea?oieo ooaiao i?e?ii?aai?ci?a – iioaioe?eieo caoaeieeao caiaeueieo
i?ioean?a o oaa?ei ? ethaeae. An? aeine?aeaeoaai? i?e?ii?aai?cie
iiaeooue ciaoiaeeoenue ia neecia?e iaieiioe? noaoaaeo oeyo?a o oaa?ei ye
iaoiaaii? aai ye i?aaenoaaieee ?aceaeaioii? /e o?aiceoi?ii? i?e?ioei?e,
a?aeiinyoueny aei i?e?ii?aai?ci?a-iii?ooi?no?a ? i?e iaaieo oiiaao
iiaeooue ni?e/eieoe iaoieia?/iee i?ioean. Iae?e iin?a?a i?iaiaeeee c
a?aooaaiiyi iaeneiaeueiiai ?inoo aeine?aeaeoaaieo eoeue-oo? ia
na?aaeiaeu?: aaeoa??aeueieo – /a?ac 24 aiae, aeoeiii?oeao?a oa a?ea?a –
/a?ac 48-72 aiae. Iae?e ?inoo cae?enithaaee iae?i- oa i?e?ineii?/ieie
iaoiaeaie. ?acoeueoaoe aeine?aeaeaiiy iaaaaeai? a oaae. 3.

Oaaeeoey 3

Ioe?iea i?ioei?e?iaii? oa i?ioea?eaeiai? aeoeaiino? aaa?iaeueieo iaee/ie

c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo

Aeaee Eiio?ieue Aeine?aei? iin?ae

(e?euee?noue a?ae?io?eueia iniiaa e?iio?eueia iniiaa

i?e?ii?aai?ci?a eieii?e a eiio?ieueieo iin?aao) ieaoeaai c Zn-2MAO*
ieaoeaai c Zn-2MAO

Micrococcus lisodeikticus 1600 1625 0 + 0

Staphylococcus aureus 155 120 0*** + 0

Micobacterium smegmatis 1500 1625 0 + 0

Bacillus subtilis H–24 +** + 0 + 0

Esherichia coli Jm–109 1360 1200 230 + +

Proteus vulgaris + + 0 + +

Pseudomonas aureginosa 1560 1500 300 + +

Klebsiella ozaonae 800 720 0 + 0

Candida albicans 1800 796 0 + 0

Noccardia asteroides 436 + + 0 + 0

Streptomyces griseus + + 0 + 0

Trichophyton rubrum + + 0 + 0

Microsporum lanosum + 1625 0 + 0

Aspergillus niger + + 0 + 0

* Zn-2MAO – oeeieiaa n?eue 2-ia?eaioiaaico?acieo; ** „+” –
nooe?eueiee ??no i?e?ii?aa-i?ci?a, ui ia i?aeaea?oueny iae?eo; ***
„0” – a?aenooi?noue ?inoo i?e?ii?aai?ci?a.

Anoaiiaeaii aaeoa??i- oa ooia?oeeaeiee aoaeo oeeieiai? nie?
2-ia?eaioiaaico?acieo o aaa?iaeueieo iaee/eao ye ia a?ae?io?euei?e, oae
? e?iio?euei?e iniiaao ia a?ai „+” oa eainoeueiaai? a?ai „–” aaeoa???, a
oaeiae iniaeea? a?oie i?e?ii?aai?ci?a: aeoeiii?oeaoe oa Noccardia
asteroides, iai?oeaey?i? a?eae ?iaeo Candida, i?oeaey?i? a?eae ?iaeo
Trichophyton, Microsporum oa Aspergillus.

Oieneeieia?/ia aea/aiiy oeeieiai? nie?

2-ia?eaioiaaico?acieo oa ii?aoeueiaaieo e?ea?nueeeo oi?i

Oieneeieia?/i? aeine?aeaeaiiy i?iaiaeeee ia aac? Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. Aeaieea Aaeeoeueeiai ?
Aea?aeaaiiai iaoeiai-aeine?aeiiai eiio?ieueiiai ?inoeoooo aaoi?aia?ao?a
? ei?iiaeo aeiaaaie.

I?e aea/aii? aino?i? oiene/iino? oeeieiai? nie? 2-ia?eaioiaaico?acieo
anoaiiaeaii, ui ?? iaeii?aciaa ia?i?aeueia aaaaeaiiy ieoai (ianith o?ea
20–25 a) oa uo?ai (ianith o?ea 150–160 a) o aeic? a?aeiia?aeii 1000 oa
3000 ia/ea iane o?ea ia aeeeeeaei caaeaae? eaai?aoi?ieo oaa?ei.
Iaeii?aciaa ia?i?aeueia aaaaeaiiy uo?ai iaee/ie o aeic? 3000 ia/ea iane
o?ea oa 4,0 ie noniaic?? oaeiae ia aeeeeeaei caaeaae? eaai?aoi?ieo
oaa?ei.

Aea?a?coth/a ? nainea?e?coth/a ae?y e?ea?nueeeo cania?a
aeine?aeaeoaaeanue ia uo?ao ? e?ieyo. Iaea?aeai? ?acoeueoaoe
i?aeoaa?aeeee a?aenooi?noue oiene/ii? ae?? ii?aoeueiaaieo e?ea?nueeeo
oi?i ia oe??o ? neecia? iaieiiee eaai?aoi?ieo oaa?ei. LD50 i?e iaoe??i?e
aie?eaoe?? oa oe??ii-i?aeueiee eiao?oe??io aeey iaee/ie ? noniaic??
aecia/eoe ia aaeaeiny /a?ac iecueeo oiene/i?noue cania?a. Aeoiaey/e c
io?eiaieo ?acoeueoao?a, oeeieiaa n?eue 2-ia?eaioiaaico?acieo –
iaeioiene/ia ?a/iaeia, a ii?aoeueiaai? ia ?? iniia? e?ea?nuee? oi?ie
iiaeia a?aeianoe aei a?oie iaeioiene/ieo cania?a.

Oa?iaeie?iaoe/ia aeine?aeaeaiiy aaa?iaeueieo iaee/ie

Aeey i?iaaaeaiiy aeine?aeaeaiue aiooaaee iaee/ee ia
aeaeaoeii-ae?oea?eiia?e iniia? cai?iiiiiaaiiai neeaaeo ianith (0,27 (
0,03) a, ai?no oeeieiai? nie? c ?ic?aooieo ia iaeio iaee/eo noaiiaea
(0,0296(0,0021) a. Ia’?eoii aeine?aeaeaiue aoee 7 a?oi oaa?ei ii 5
uo??a-naiie o eiaei?e. Iaee/ee aaiaeeee ?io?aaaa?iaeueii. Eiio?ieai aoee
7 a?oi oaa?ei, yeei aaiaeeee iaee/ee-ieaoeaai. I?ney aeaeai?oaoe?? /a?ac
1; 2,5; 3,5; 5; 6; 8 ? 24 aiae. a?ae iiiaioo aaaaeaiiy aaa?iaeueieo
iaee/ie aeine?aei?e ? eiio?ieuei?e a?oi? oaa?ei aeey aeine?aeaeaiiy
a?aee ianooii? i?aaie: aieiaiee iicie, ia/?ieo, naeac?ieo, ie?ee oa
i?oao c ai?noii (caeeoee ?icoiieaii? iaee/ee).

=881,0). ?acoeueoaoe aeine?aeaeaiiy i?aaenoaaeai? ia ?en. 2.

?en. 2. Aeeiai?ea ?iciiae?eo a /an? ii i?aaiao i?e aaa?iaeueiiio niinia?
aaaaeaiiy o oi?i? aeaeaoeii-ae?oea?eiiaeo iaee/ie oeeieiai? nie?
2-ia?eaioiaaico?acieo.

Anoaiiaeaii, ui oeeieiaa n?eue 2-ia?eaioiaaico?acieo iia?eueii
aea?eueiy?oueny ?c e?ea?nueei? oi?ie (aei 8 aiae). Iniiaia e?euee?noue
aeine?aeaeoaaii? ?a/iaeie caeeoa?oueny o i?noe? aaaaeaiiy, i?aeo?eioth/e
iaeneiaeueio oa?aiaaoe/io eiioeaio?aoe?th. I?noeaaa (eieaeueia) ae?y
aaa?iaeueieo iaee/ie ?c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo ?
iaei??th c oiia ?o aoaeoeaiino? o oa?ai?? aiaeiiao?eoo a?eaeiai? oa
aaeoa??aeueii? ao?ieia??.

Aea/aiiy niaoeeo?/ii? aoaeoeaiino? noniaic?? oa aaa?iaeueieo iaee/ie

Oa?iaeieia?/i? aeine?aeaeaiiy i?iaiaeeee ia aac? Aea?aeaaiiai
iaoeiai-aeine?aeiiai eiio?ieueiiai ?inoeoooo aaoi?aia?ao?a ? ei?iiaeo
aeiaaaie. O oaa?ei (o oiio /ene? ? na?enueeeo) /anoi cono??/athoueny
a?eaeia? o?aaeaiiy oe??e, na?aae yeeo no?eao/ee eeoae – caoai?thaaiiy,
ui iaaoei oe?ieiai ?iciianthaeaeaiiy ? aaaeei i?aeaea?oueny e?eoaaiith.
Caoaeieee no?eao/iai eeoath – a?eae ?iaeo Trichophyton ? Microsporum,
/ooeea? aei ae?? oeeieiai? nie? 2-ia?eaioiaaico?acieo. Aeine?aeaeoaaee
aoaeoeai?noue canoinoaaiiy noniaic?? „Ia?eaioiae?iaen” i?e aeaiiio
caoai?thaaii? o oaa?ei (cie?aia o niaae oa aaeeei? ?iaaoi? ooaeiae).
Anoaiiaeaii, ui ii?yae c i?ioea?eaeiaith ae??th, noniaic?y i?iyaey?
ae?aaeaiee i?ioecaiaeueiee aoaeo. Nei?i/othoueny oa?i?ie e?eoaaiiy
oaa?ei, iiai?noth a?aeiiaeth?oueny oa?noyiee iie?ea. Noniaic?y aoaeoeaia
iaa?oue o aeiaaeeao, eiee o?aaeaiiy oe??e aeinyaa? 30 % ieiu? iiaa?oi?
o?ea.

Aea/aii niaoeeo?/io aoaeoeai?noue iaee/ie c oeeieiaith n?eeth
2-ia?eaioiaaico?acieo i?e i?io?eaeoeoe? oa e?eoaaii? aiaeiiao?eoo
aaeoa??aeueii? oa a?eaeiai? ao?ieia?? o aaeeei? ?iaaoi? ooaeiae.
Anoaiiaeaii, ui o ii??aiyii? c io?oeeiaeueiei caniaii – iaee/eaie
oo?acie?aeiio, cai?iiiiiaai? iaie iaee/ee c oeeieiaith n?eeth
2-ia?eaioiaaico?acieo i?iyaeythoue aeuo (ia 18,5–25,0 %) oa?aiaaoe/io
aeoeai?noue. A ?acoeueoao? ciaioo?oueny e?euee?noue aaaaeaiue
e?ea?nueeiai caniao oa nei?i/o?oueny o?eaae?noue e?eoaaiiy.

A E N I I A E E

1. Ii?aoeueiaaii iaoiaeeeo iaea?aeaiiy oaeaoii? niieoee oeeieo c
2-ia?eaioiaaico?acieii. Ooai?aiiy na?aaeiuei? nie? oa /enoioo
neioaciaaii? niieoee i?aeoaa?aeaeaii niaeo?aie II?.

2. ?ic?iaeaii iaoiaeeee ye?niiai oa e?euee?niiai aiae?co noanoaioe?? –
oeeieiai? nie? 2-ia?eaioiaaico?acieo iaoiaeaie cai?ioiiai
eiiieaeniiiiao?e/iiai oeo?oaaiiy, iiey?ia?ao?? oa niaeo?ioioiiao???.
A?aeiinia iioeaea iaoiae?a aiae?co ia ia?aaeuo? 2,2 %.

3. A ?acoeueoao? aecia/aiiy aino?i? oiene/iino? oa i?iaaaeaiiai
i?e?ia?ieia?/iiai aeine?aeaeaiiy ia noaiaea?oieo ooaiao i?e?ii?aai?ci?a
anoaiiaeaii, ui oeeieiaa n?eue 2-ia?eaioiaaico?acieo iaeaaeeoue aei
a?oie iaeioiene/ieo ?a/iaei ? i?iyaey? oe?ieee niaeo? i?ioea?eaeiai? oa
i?ioei?e?iaii? aeoeaiino?.

4. Ia iniia? eiiieaenieo no?oeoo?ii-iaoai?/ieo, oaoiieia?/ieo,
i?e?ia?ieia?/ieo oa oa?iaeieia?/ieo aeine?aeaeaiue ?ic?iaeaii
iioeiaeueiee neeaae ? oaoiieia?th noniaic?? „Ia?eaioiae?iaen” oa
aaa?iaeueieo iaee/ie „Ia?eaaai”, iniiaiith ae?th/ith ?a/iaeiith yeeo ?
oeeieiaa n?eue 2-ia?eaioiaaico?acieo.

5. Aeey noaiaea?oecaoe?? ii?aoeueiaaieo e?ea?nueeeo oi?i ? anoaiiaeaiiy
oa?i?io ?o i?eaeaoiino? iiaeeo?eiaaii iaoiaeeee ye?niiai oa e?euee?niiai
aecia/aiiy ai?noo oeeieiai? nie? 2-ia?eaioiaaico?acieo o noniaic?? oa
aaa?iaeueieo iaee/eao iaoiaeaie cai?ioiiai eiiieaeniiiiao?e/iiai
oeo?oaaiiy, iiey?ia?ao?? oa niaeo?ioioiiao???. Cai?iiiiiaai? iaoiaeeee
a?aecia/athoueny aeia?ith ?ai?iaeoeoeai?noth ?acoeueoao?a oa
/ooeea?noth.

6. Anoaiiaeaii, ui o i?ioean? caa??aaiiy noniaic?? oa aaa?iaeueieo
iaee/ie i?ioyaii 15 oa 18 i?nyoe?a a?aeiia?aeii, ?o iniiai?
o?ceei-o?i?/i? aeanoeaino? oa niaeo? i?ioei?e?iaii? ? i?ioea?eaeiai?
aeoeaiino? i?aeoe/ii ia ci?iththoueny.

7. Aeyaeaii aenieo oa?aiaaoe/io aoaeoeai?noue noniaic??
„Ia?eaioiae?iaen” i?e e?eoaaii? aea?iaoieia?/ieo caoai?thaaiue oe??e o
oaa?ei, aeeeeeaieo a?eaaie ?iaeo Trichophyton ? Microsporum oa cia/io
aoaeoeai?noue aaa?iaeueieo iaee/ie „Ia?eaaai” aeey i?io?eaeoeee oa
e?eoaaiiy aiaeiiao?eoo aaeoa??aeueii? ? a?eaeiai? ao?ieia?? o aaeeei?
?iaaoi? ooaeiae. A ?acoeueoao? oa?iaeieia?/ieo aeine?aeaeaiue
anoaiiaeaii a?aenooi?noue i?noeaaiiiae?acithaaeueii? ae?? oa
iaoe?aeeea?noue ii?aoeueiaaieo cania?a.

8. Ia iniia? oa?iaeie?iaoe/ieo aeine?aeaeaiue anoaiiaeaii, ui
aaa?iaeuei? iaee/ee c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo ia
aeaeaoeii-ae?oea?eiia?e iniia? ia i?iyaeythoue
i?noeaaiiiae?acithaaeueiiai aieeao ? ? caniaii i?noeaai? (eieaeueii?)
ae??.

9. Ca ?acoeueoaoaie i?iaaaeaieo aeine?aeaeaiue i?aeaioiaeaii
ii?iaoeaii-oaoi?/io aeieoiaioaoe?th ia ii?aoeueiaai? e?ea?nuee? oi?ie.
?ic?iaeai? oa caoaa?aeaeai? OO 46.15.086–95 ia noniaic?th
„Ia?eaioiae?iaen”, „Ianoaiiaa ii canoinoaaiith noniaic?? Ia?eaioiae?iaen
aeey e?eoaaiiy aea?iaoieia?/ieo caoai?thaaiue o nnaaoe?a” oa OO O 46
15.206.97 ia „Noiice-oi??? Ia?eaaai aeey aaoa?eia???” ? „Ianoaiiaa ii
canoinoaaiith noiiceoi???a Ia?eaaai o aaoa?eia?i?e iaaeeoeei?”.

Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe??:

1. ssai?nueea I.I. Aeine?aeaeaiiy a?ieia?/ii? aeoeaiino? iio?aeieo
2-ia?eaioiaaico?acieo oa ii?aoethaaiiy ia ?o iniia? iiaeo e?ea?nueeeo
oi?i // Oa?iaoeaao. aeo?iae.– 1997.– ?2.– N. 101–104.

2. ssai?nueea I.I. Oaoiieia?y oa e?euee?nia aecia/aiiy o caniaao caoenoo
oaa?ei oeeieiai? nie? 2-ia?eaioiaaico?acieo (Iia?aeiieaiiy ia?oa) //
A?niee iaoe. aeine?aeaeaiue.– 1998.– ? 7-8.– N. 34–36.

3. ssai?nueea I.I., Ca?oia E.?., Aa/einueea ?.TH. Aeine?aeaeaiiy oa
ioe?iea yeino? iacae c oeeieiaith n?eeth 2-ia?eaioiaaico?acieo
(Iia?aeiieaiiy ae?oaa) // A?niee iaoe. aeine?aeaeaiue.– 1998.– ? 7-8.–
N. 36–38.

4. Yavors’ka O., Zarooma L. New medicine for treatment of endometritis
in animals // European journal of pharmaceutical sciences (Official
Journal of the European Federation for Pharmaceutical Sciences).– 1998.–
Vol. 6, Suppl. 1.– ?. S77.

5. ssai?nueea I.I. Iiaa e?ea?nueea oi?ia aeey e?eoaaiiy a?eaeiaeo
o?aaeaiue oe??e // ?ioaeoe?ei? oai?iae. ?acoeueoaoe iaoeiai-aeine?aeii?
?iaioe, aeena?oaoe?eieo aeine?aeaeaiue: Ca. ?ia?o / Euea?a. aea?ae.
iaae. oi-o.– Euea?a, 1994.– Aei.I. – N. 55–56.

6. Canoinoaaiiy noniaic?? „Ia?eaioiae?iaen” i?e a?eaeiaeo caoai?thaaiiyo
/ I.?.Na?a?-?iei, A.O.Ieiea, ?.E.Aaaeinue?aa, A.A.?aaai/oe,
A.I.Iaeei?anueeee, I.I.ssai?nueea // Oai aea.– N. 56–57.

7. Ieiea A.O., Ei?i?e/oe I.I., ssai?nueea I.I. Aeine?aeaeaiiy
i?ioea?eaeiai? ae?? eiii-eaenieo niieoe iaaaoecieo // ?ioaeoe?ei?
oai?iae. ?acoeueoaoe iaoeiai-aeine?aeii? ?iaioe, aeena?oaoe?eieo
aeine?aeaeaiue: Ca. ?ia?o / Euea?a. aea?ae. iaae. oi-o.– Euea?a, 1995.–
Aei. 3.– N.42.

8. Iao?oeia A.A., Ca?oia E.?., ssai?nueea I.I. Ioe?iea yeino?
i?ioea?eaeiai? noniaic?? „Ia?eaioiae?iaen” // Oai aea.– N. 43.

9. Canoinoaaiiy i?aia?aoo „Ia?eaioiae?iaen” aeey e?eoaaiiy o?eoio?o?? /
A.O.Ieiea, A.A.Iao?oeia, I.I.ssai?nueea, I.?.Na?a??iei, ?.E.Aaaeinue?aa,
A.A.?aaai/oe, ?.E.Iaeueie/oe, A.I.Iaeei?anueeee // Oai aea.– N. 44.

10. Aeine?aeaeaiiy ooaa?eoeinoaoe/ii? aeoeaiino? eiiieaenii? niieoee
iaaaoecieo in vitro / I.I.ssai?nueea, ?.A.?eueieoeueeee, E.I.
ssai?nueea, A.I.Ai?ioei // ?ioaeoe?ei? oai?iae. ?acoeueoaoe
iaoeiai-aeine?aeii? ?iaioe, aeena?oaoe?eieo aeine?aeaeaiue: Ca. ?ia?o /
Euea?a. aea?ae. iaae. oi-o.– Euea?a, 1996.– Aei.4.– N. 33.

11. Noai?aiiy iiaiai i?ioeaiaeiiao?eoiiai i?aia?aoo Ia?eaaai ? aea/aiiy
eiai oa?aiaaoe/ii? ae?? / I.A.Einaiei, I.I.ssai?nueea, A.A.?aaai/oe,
?.I.Iaoa?aaa, E.?.Ca?oia, I.I.Iaeiaiinueea // Ca??iee i?aoeue
ni?a?ia?oiee?a ?inoeoooo: Aei 20-??//y canioaaiiy Aea?aeaaii?
iaoeiai-aeine?aeii? eiio?ieueii? onoaiiae aaoa?eia?ieo i?aia?ao?a ?
ei?iiaeo aeiaaaie a Oe?a?i? / Aea?ae. iaoeiai-aeine?aeiee eiio?ie. ?i-o
aaoi?aia?ao?a ? ei?iiaeo aeiaaaie.– Euea?a, 1996.– N. 51–52.

12. Ieiea A., Iao?oeia A., ssai?nueea I. Noniaic?y „Ia?eaioiae?iaen” –
iiaee can?a aeey e?eoaaiiy aea?iaoii?eic?a // ? Eiia?an Na?oiai?
Oaaea?aoe?? oe?a?inueeeo oa?iaoeaaoe/ieo oiaa?enoa (Euea?a, 27-29 o?aaiy
1994 ?.): Oace aeiiia.– Euea?a, 1994.– N. 134–135.

13. Ia?eaioiae?iaen – i?ioea?eaeiaee i?aia?ao aeey i’yni?aeieo /
?.E.Aaaeinue?aa, A.A.?aaai/oe, ?.E.Iaeueie/oe, I.A.Aana?aa, I.I.
ssai?nueea // I?iaeaie aaoa?eia?iiai ianeoaiaoaaiiy ae??aieo aeiiaoi?o
oaa?ei: Ca. iaoa??ae?a ??? I?aeia?iaeii? iaoeiai-i?aeoe/ii? eiioa?aioe??
(8-9 aeiaoiy 1998 ?., i. Ee?a, Oe?a?ia).– Ee?a, 1998.– N. 88–89.

ssai?nueea I.I. Aeine?aeaeaiiy oaeaoii? niieoee oeeieo c
2-ia?eaioiaaico?acieii oa ?ic?iaea e?ea?nueeeo oi?i ia ??
iniia?.–?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa oa?iaoeaaoe/ieo
iaoe ca niaoe?aeuei?noth 15.00.01 – oaoiieia?y e?e?a oa i?iieneiaa
oa?iaoe?y. – Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. Aeaieea
Aaeeoeueeiai, Euea?a, 1998.

Aeena?oaoe?y i?noeoue ?acoeueoaoe aenia?eiaioaeueieo aeine?aeaeaiue
uiaei io?eiaiiy oaeaoii? niieoee oeeieo c 2-ia?eaioiaaico?acieii,
i?aeoaa?aeaeaiiy ?? no?oeoo?e, aiae?co, aea/aiiy oiene/iino? oa
a?ieia?/ii? aeoeaiino?. A ?iaio? iaaaaeaii ?acoeueoaoe aeine?aeaeaiue ii
iaa?oiooaaiith neeaaeo, oaoiieia??, aiae?co oa aea/aiith oa?iaeieia?/ii?
? i?e?ia?ieia?/ii? aeoeaiino? e?ea?nueeeo cania?a ia iniia? oeeieiai?
nie? 2-ia?eaioi-aaico?acieo: i?ioea?eaeiai? noniaic?? „Ia?eaioiae?iaen”
? aaa?iaeueieo iaee/ie „Ia?ea-aai” aeey i?io?eaeoeee oa e?eoaaiiy
aiaeiiao?eoo.

Eeth/ia? neiaa: oaeaoia niieoea oeeieo c 2-ia?eaioiaaico?acieii, aiae?c,
noniaic?y, aaa?iaeuei? iaee/ee, oa?iaeieia?/i?, i?e?ia?ieia?/i?
aeine?aeaeaiiy, i?ioea?eaeiaee, i?ioeaiaeiiao?eoiee can?a.

ssai?neay I.I. Enneaaeiaaiea oaeaoiiai niaaeeiaiey oeeiea n
2-ia?eaioiaaicoeacieii e ?ac?aaioea eaea?noaaiiuo oi?i ia aai
iniiaa.–?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa oa?iaoeaaoe/aneeo
iaoe ii niaoeeaeueiinoe 15.00.01 – oaoiieiaey eaea?noa e i?iiuoeaiiay
oa?iaoeey. – Eueaianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei.
Aeaieea Aaeeoeeiai, Eueaia, 1998.

Aeenna?oaoeey niaea?aeeo ?acoeueoaou yenia?eiaioaeueiuo enneaaeiaaiee ii
iieo/aieth oaeaoiiai niaaeeiaiey oeeiea n 2-ia?eaioiaaicoeacieii,
iiaeoaa?aeaeaieth aai no?oeoo?u, aiaeeco, eco/aieth oiene/iinoe e
aeieiae/aneie aeoeaiinoe. A ?aaioa i?eaaaeaiu ?acoeueoaou enneaaeiaaiee
ii iainiiaaieth ninoaaa, oaoiieiaee, aiaeeco e eco/aieth
oa?iaeieiae/aneie e iee?iaeieiae/aneie aeoeaiinoe eaea?noaaiiuo n?aaenoa
ia iniiaa oeeieiaie niee 2-ia?eaioiaaicoeaciea: i?ioeaia?eaeiaie
noniaicee „Ia?eaioiaeeiaen” e aaaeiaeueiuo iaei/ae „Ia?eaaai” aeey
i?ioeeaeoeee e ea/aiey yiaeiiao?eoa.

Eeth/aaua neiaa: oaeaoiia niaaeeiaiea oeeiea n 2-ia?eaioiaaicoeacieii,
aiaeec, noniaicey, aaaeiaeueiua iaei/ee, oa?iaeieiae/aneea,
iee?iaeieiae/aneea enneaaeiaaiey, i?ioeaia?eaeiaia,
i?ioeaiyiaeiiao?eoiia n?aaenoai.

Yavors’ka O.P. Studies of zink complex of 2-merkaptobenzothiazole and
elaboration of the medicinal forms on its basis. – Manuscript.

Dissertation for scientific degree of Candidate of Pharmacy in
speciality 15.00.01 – technology of drug and manufacture pharmacy.– The
Lviv State Medical University after Danylo Halytskiy, Lviv, 1998.

The thesis contains results of experimental research on deriving of zinc
complex of 2-merkaptobenzothiazole, confirmation of its structure,
analysis, study of toxicity and biological activity. The work also
reports findings of the study of substantiating of its composition,
technology, analysis and assessment of pharmacological and
microbiological effects of the remedies on the basis of zinc salt of
2-merkaptobenzothiazole: antifungial suspension „Merkaptodimex” and
vaginal bacilli „Merkaben” for prevention and treatment of endometritis.

Key words: zink complex of 2-merkaptobenzothiazole, analysis,
suspension, vaginal bacilli, pharmacological, microbiological research,
antifungial, antiendometritis remedies.

I?aeienaii aei ae?oeo 18.11.98. Oi?iao 60(84 1/16

Iai?? ae?oea?nueeee. Ae?oe Riso. 1,0. Oi. ae?oe. a?e. 1.

Iae.-aeae. A?e. 1,25. Iaeeaae 100.

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