2

OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Eiiae?ia Ieueaa Aanee?aia

OAeE 616.12-008.331.1-085.225.2

Aeeoa?aioe?eiaaia i?ecia/aiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai
oa?iaioo oa aeieaoi??a ?aoeaioi??a aia?ioaiceia II i?e ??cieo noaae?yo
anaioe?aeueii? a?ia?oaic??

14.01.11 — ea?ae?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Eaoiaoc ?aai E?iae?aoiae/, Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e aioo??oi?o
oai?ia, EOE oa NI.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeueiaa Ieueaa Ieeiea?aia,
Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia ?1;

eaiaeeaeao iaaee/ieo iaoe, aeioeaio Oonoaaeue Ieeiea Oaaei?iae/,
Oa?e?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe, caa?aeoaa/
eaoaae?e ea?ae?ieia?? oa ooieoe?iiaeueii? ae?aaiinoeee.

I?ia?aeia onoaiiaa:

?inoeooo ea?ae?ieia?? ?iai? aeaaeai?ea I.Ae. No?aaeanea AII Oe?a?ie,
a?aeae?e a?ia?oii?/ii? oai?iae.

Caoeno a?aeaoaeaoueny “_14__” aeiaoiy 1999 ?. i _13 — 30__ aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ( 310022,

i. Oa?e?a, i?. Eai?ia, 4.)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?. Eai?ia,
4.)

Aaoi?aoa?ao ?ic?neaiee “ _3_ “ _aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee, e.i.i, aeioeaio. E.?. Ia/a?aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aeniea ?iciianthaeaeai?noue a?oa??aeueii?
a?ia?oaic?? (AA) a Oe?a?i? (ca?aeii aeaieo ai?aeai?ieia?/ieo
aeine?aeaeaiue aiia neeaaea? aei 20% ianaeaiiy), ca?eueoaiiy ia oii?
i?aeaeuaiiai a?oa??aeueiiai oeneo ?eceeo nia?oiino?, aeieeiaiiy
?oai?/ii? oai?iae na?oey (?ON), ?inoeueoo, na?oeaai? iaaeinoaoiino?
(NI), o?ii?/ii? ie?eiai? iaaeinoaoiino?, iia’ycai? c oeei iaaee/i? oa
nioe?aeuei? i?iaeaie, a oaeiae aeiiii?/i? cao?aoe iaoiiaeththoue
iino?eiee ?ioa?an aei i?iaeai iaoiaaiaco oa e?eoaaiiy aeaiiai
caoai?thaaiiy. (?.I.Ni??iiaa, 1998, V.J.Dzau, G. Gibbons, 1991, S.
MacMahon et al., 1997).

A ca’yceo c oni?oaie iieaeoey?ii? a?ieia?? oa aenia?eiaioaeueii?
iaaeeoeeie noaei iiaeeeaei aea/aiiy iaei??? c iaea?eueo oe?eaaeo i?iaeai
a oe?e iaeano? — ?ie? aiaeioae?aeueii? aeenooieoe?? a iaoiaaiac? AA
(P.M. Vanhoutte, 1993, C.J. Ferro, D.J. Webb, 1997).

A ?acoeueoao? aaaaoi/enaeueieo aeine?aeaeaiue aoei anoaiiaeaii, ui
aiaeioae?aeuei? ee?oeie neioacothoue oa aea?eueiththoue a?ieia?/ii
aeoeai? ?a/iaeie, ye? eiio?ieththoue oiion oa ??no aeaaeaiueeii’yciai?
ioneoeaoo?e noaeei. Oe? noanoaioe?? aeeth/athoue iiooaei?
aaciaeeeaoaoi?e oa ?ia?a?oi?e oaeoi??a ?inoo — ieneae acioo (NO),
iao??eo?aoe/iee iaioeae oeio N, i?inoaoeeee?i, iaaeaaii a?aee?eoee
iaioeae aae?aiiiaaeoe?i oa aiaeioae?i-1 (AO-1) — iaeei c naieo
iiooaeieo na?aae a?aeiieo ia nueiaiaeiyoi?e aeaiue aacieiino?eeoi??a
(I.I. Ai?aa/aaa e ae?., 1991, C.B. Treasure, 1993, J.C. Burnett, 1997).

A ee?i?/ieo oiiaao ii?ooaiiy aiaeioae?aeueii? ooieoe?? ? ?ieue a ieo
AO-1 ? nenoaie NO iaea?eueo aea/aii i?e aoa?ineea?ic?. Aeey AA ia
nueiaiaeiyoi?e aeaiue a?aeiii, ui i?aeaeuaiiy a?oa??aeueiiai oeneo (AO)
o oaeeo oai?eo anioe?th?oueny c iia??oaiiyi aiaeioae?e-caeaaeii?
aaci?aeaenaoe??. Aeenooieoe?y aiaeioae?y iiaea aooe aeyaeaia i?e
canoinoaaii? oaeeo aaii?no?a, ye aoeaoeeoie?i aai a?aae?e?i?i, ye?
ae?thoue ia ??ai? ??ciiiai?oieo ?aoeaioi??a oa oeyo?a ia?aaea/?
i?aeee?oeiiiai neaiaea (A.Lerman, 1995).

E??i oeueiai, AA oaeiae oa?aeoa?eco?oueny no?oeoo?ieie ii?ooaiiyie
noaeei, ye? i?eaiaeyoue aei i?aeaeuaiiy ni?aa?aeiioaiiy oiaueia
no?iee/aioo??oi?e ae?aiao? noaeeie. Oe? no?oeoo?i? ii?ooaiiy a??ia?aeii
yaeythoueny e?eoe/ieie aeey i?aeo?eiee oa i?ia?anoaaiiy a?ia?oaic??,
iacaeaaeii a?ae ?? ao?ieia??. A oeueiio ca’yceo aaaeeeai i?aee?aneeoe,
ui ?ai?i-aia?ioaiceiiaa nenoaia a?a? eeth/iao ?ieue a iiaeoeyoe??
noaeeiii? no?oeoo?e i?e a?ia?oaic?? (M. Caulfield et al., 1994, J.
Beige, 1997).

I?aia?aoe, ye? canoiniaothoue aeey e?eoaaiiy AA, iiaeii? ia o?eueee
aoaeoeaii cieaeoaaoe ??aaiue AO, aea e iiceoeaii aieeaaoe ia i?ioeane
?aiiaeaethaaiiy noaeei oa na?oey. Oae, ?ia?a?oi?e
aia?ioaiceiia?aoai?thth/iai oa?iaioo (AIO), ye aoei iieacaii a
??ciiiai?oieo aeine?aeaeaiiyo, ia o?eueee aoaeoeaii cieaeothoue ??aaiue
AO, aea e ca ?aooiie aeieaaee ooai?aiiy aia?ioaiceio II oa i?aeaeuaiiy
ai?noo a?aaeee?i?io (ui i?eaiaeeoue aei aea?eueiaiiy ieneaeo acioo oa
i?inoaoeeee?io) aeyaeythoue ni?eyoeea? aoaeoe ia ooieoe?th aiaeioae?y
(K.B. Brosnihan et al., 1996, D.J. Campbell et al., 1996).

Ia a?aei?io a?ae ?ia?a?oi??a AIO aioaaii?noe ?aoeaioi??a aia?ioaiceia II
caaacia/othoue niaoeeo?/io aeieaaeo ?aoeaioi??a aia?ioaiceio II ia?oiai
oeio ? ia i?aeaeuothoue ??aaiue a?aaeee?i?io (K. Tsunoda et al., 1993,
C.I. Johnston et al., 1997). Iaeiae, aei oaia??oiueiai /ano ia aea/aii
ii??aiyiee aieea ?ia?a?oi??a AIO oa aeieaoi??a ?aoeaioi??a aia?ioaiceia
II ia iieacieee, ye? oa?aeoa?ecothoue ooieoe?th aiaeioae?th o oai?eo c
AA ? ia ?ic?iaeaii aeeoa?aioe?eiaai? noaie i?ecia/aiiy oeeo i?aia?ao?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iaoa??aee
aeena?oaoe?? aeieeaathoue c ieaiiaeo iaoeiai-aeine?aeieo ?ia?o
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. Aeena?oaoe?eia
?iaioa ? neeaaeiaith /anoeiith iaoeiai-aeine?aeieo ?ia?o eaoaae?e
“Iaoieia?y na?oeaai-noaeeiii? nenoaie” ? Aea?ae. ?a?no?aoe??
01950023462.

Iaoa aeine?aeaeaiiy. ?ic?iaea noai aeeoa?aoe?eiaaiiai i?ecia/aiiy
?ia?a?oi?a AIO aiaeai?eea iaeaaoa oa aioaaii?noa ?aoeaioi??a
aia?ioaiceia II eica?oaia ia iniia? aea/aiiy ?o aieeao ia
aeaeo?iea?ae?ia?ao?/i? oa aaiiaeeiai?/i? ia?aiao?e ? iieacieee, ye?
oa?aeoa?ecothoue ooieoe?th aiaeioae?y o oai?eo c ??cieie oi?iaie AA aeey
i?aeaeuaiiy aoaeoeaiino? oa?ai?? oa iie?auaiiy i?iaiico caoai?thaaiiy.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe ee?i?/io aoaeoeai?noue oa aacia/i?noue oa?ai?? aiaeai?eea
iaeaaoii (?ai?oae) ? eica?oaiii (eicaa?) o oai?eo c ??cieie ee?i?/ieie
oi?iaie AA.

2. Aecia/eoe ??ai? AO-1 oa aoi?eiiiai ianaiaeaea?a NO – oeAIO oa
ioe?ieoe ni?aa?aeiioaiiy aacieiino?eeoi?ieo (AO-1) ? aaciaeeeaoaoi?ieo
(oeAIO) oaeoi??a i?e ??cieo ee?i?/ieo oi?iao AA.

3. Anoaiiaeoe aieea ia aiaeioae?aeueio aeenooieoe?th ?i?aa?oi?a AIO
aiaeai?eea iaeaaoa oa aioaaii?noa ?aoeaioi??a aia?ioaiceia II eica?oaia
ia i?aenoaa? aeeiai?ee ??ai?a AO-1 ? oeAIO i?ae aieeaii oa?ai?? aeaieie
i?aia?aoaie o oai?eo c AA.

4. Aeine?aeeoe aeeiai?eo aeaeo?iea?ae?ia?ao?/ieo iieaciee?a ?
aaiiaeeiai?/ieo ia?aiao??a o oai?eo c AA i?ae aieeaii oa?ai?? aiaeai?eea
iaeaaoii oa eica?oaiii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aea/aia ii??aiyeueia ee?i?/ia
aoaeoeai?noue oa aacia/i?noue oa?ai?? ?i?a?a?oi?a AIO aiaeai?eea iaeaaoa
oa aeieaoi?a ?aoeaioi??a aia?ioaiceia II eica?oaia o oai?eo c ??cieie
ee?i?/ieie oi?iaie AA. Anoaiiaeaia caeaaei?noue ee?i?/ieo i?iya?a oa
??ai?a AO a?ae nooiaith aiaeioae?aeueii? aeenooieoe??, yeo ioe?ithaaee
ii ??aiyi AO-1 ? oeAIO, oa iiaeeea?noue iie?auaiiy ooieoe?? aiaeioae?th
i?ae aieeaii oa?ai?? i?aia?aoaie, ui aea/aeenue. Iieacaii iiceoeaiee
aieea aeieaoi??a ?ai?i-aia?ioaiceiiai? nenoaie ia aaiiaeeiai?/i? oa
aeaeo?iea?ae?ia?ao?/i? iieacieee, ui i?iyaeyany aeey aiaeai?eea iaeaaoa
a a?eueo?e /anoio? ii?iae?caoe?? e?ioeaai? /anoeie oeoii/eiaiai
eiiieaeno AEA ? a a?eueo cia/ouiio cieaeaii? caaaeueiiai ia?eoa?e/iiai
iii?o noaeei, a aeey eica?oaia — a a?eueo cia/eiiio iie?auaii?
aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai ?iaeaena. Aeyaeaii, ui ??ai? AO
oa noaae?y AA a cia/i?e i??? aecia/athoueny ai?noii AO-1 ? oeAIO, a
oaeiae ?o ni?aa?aeiioaiiyi – i?aeaeuaiiy eiioeaio?aoe?? aacieiino?eeoi?a
AO-1 oa aeniaaeaiiy iiaeeeaino? eiiiainaoi?iiai neioaco aaciaeeeaoaoi?a
NO aecia/a? nooi?iue aiaeioae?aeueii? aeenooieoe?? ?, ye iane?aeie,
??ai? AO oa noaae?th AA. Oa?ai?y aeieaoi?aie ?ai?i-aia?ioaiceiiai?
nenoaie ni?ey? iie?auaiith ooieoe?? aiaeioae?y.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iieacaia aeniea ee?i?/ia
aoaeoeai?noue oa?ai?? AA aeieaoi?aie ?ai?i-aia?ioaiceiiai? nenoaie i?e
a?eueo?e aacia/iino? eica?oaia a ii??aiyii? c aiaeai?eea iaeaaoii.
Aeyaeaii, ui ni?aa?aeiioaiiy aacieiino?eeoi??a oa aaciaeeeaoaoi??a
(AO-1/oeAIO) ia ?aii?o noaae?yo caoai?thaaiiy ciaoiaeeoueny a ?aieao
ii?iaeueieo cia/aiue, oiae? ye i?ia?anoaaiiy AA noi?iaiaeaeo?oueny
i?aeaeuaiiyi aeaiiai ni?aa?aeiioaiiy. Oa?ai?y aeieaoi?aie
?ai?i-aia?ioaiceiiai? nenoaie i?eaiaeeoue aei iie?auaiiy aeaiiai
ni?aa?aeiioaiiy, i?e/iio i?e iii??i?e oa aaaee?e oi?i? AA aieea
aiaeai?eea iaeaaoa ia aiaeioae?aeueio aeenooieoe?th ? a?eueo cia/ouei ca
?aooiie a?eueoiai i?aeaeuaiiy ai?noo a ieaci? aoi?eiiiai ianaiaeaea?a
ieneaea acioa — oeAIO ?, a?aeiia?aeii, a?eueoiai cieaeaiiy
ni?aa?aeiioaiiy AO-1/oeAIO.

Aeyaeaii, ui canoinoaaiiy aiaeai?eea iaeaaoa a ii??aiyii? c eica?oaiii o
oai?eo c AA a?eueo iieacaii o iaoe??io?a c? ci?iaie e?ioeaai? /anoeie
oeoii/eiaiai eiiieaeno AEA, iniaeeai ?oai?/iiai iioiaeaeaiiy, ? i?e
iaiao?aeiino? oaeaeeiai cieaeaiiy caaaeueiiai ia?eoa?e/iiai iii?o
noaeei, oiae? ye aeei?enoaiiy eica?oaia ia? ia?aaaae o oai?eo c aenieei
?eceeii iani?eyoeeaiai ia?aa?ao caoai?thaaiiy, yeee iiaea aooe
?ic?aoiaaii ca aeiiiiiaith aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai
?iaeaena.

Aeai?, io?eiai? i?e aeeiiaii? ?iaioe, aeei?enoiaothoueny a
iaaeaaia?/iiio i?ioean? ia eaoaae?? aioo??oi?o oai?ia, EOE oa NI
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. ?acoeueoaoe
aeine?aeaeaiiy ai?iaaaeaeaii a i?aeoeeo ?iaioe ?inoeoooo oa?ai?? AII
Oe?a?ie, aei?iaeii? ee?i?/ii? e?ea?i? ?2 ICAe, i?nueei? ee?i?/ii?
e?ea?i? ?27 i. Oa?eiaa, i?nueei? ee?i?/ii? e?ea?i? ?28 i. Oa?eiaa,
Oa?e?anueei? iaeanii? nooaeaionueei? e?ea?i?, i?nueei? ee?i?/ii? e?ea?i?
?11 i. Oa?eiaa.

Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai iniaenoi i?iaiae?ciaaia iaoeiaa
e?oa?aoo?a ii i?iaeai?, ui aea/aeanue, i?iaaaeaii
ee?i?ei-?ino?oiaioaeueia ianoaaeaiiy, a oiio /ene? oeueo?acaoeiaa
ianoaaeaiiy oa ia?iaea aeaieo aeaeo?iea?ae?ia?ao?? c aeei?enoaiiyi
i?ea?iaeueii? iaoiaeeee. ?ic?iaeaia noaia aeeoa?aioe?eiaaiiai
i?ecia/aiiy aiaeai?eea iaeaaoa ? eica?oaia a caeaaeiino? a?ae oi?ie oa
nooiaith a?oa??aeueii? a?ia?oaic??. Aaoi?ii i?iaaaeaia noaoenoe/ia
ia?iaea ? aiae?c io?eiaieo ?acoeueoao?a c aeei?enoaiiyi no/anieo
iaoaiaoe/ieo iaoiae?a oa eiii’thoa?ii? oaoi?ee. Caeiaoaa/ai naiino?eii
iaienai? an? ?icae?ee ?iaioe, noi?ioeueiaaii aeniiaee oa i?aeoe/i?
?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aeaeeny oa iaaiai?thaaeeny ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo
iieiaeeo a/aieo (Oa?e?a, 1996, 1997), can?aeaiiyo Oa?e?anueeiai
iaoeiai-iaaee/iiai oiaa?enoaa (Oa?e?a, 1998), iaoeiai-i?aeoe/i?e
eiioa?aioe??, i?enay/ai?e i?iaeaiai aei?iaeiuei? iaaeeoeeie (Oa?e?a,
1997) oa iaoeiai-i?aeoe/i?e eiioa?aioe?? “Iia? ai?eciioe ee?i?ee
aioo??oi?o caoai?thaaiue” (Oa?e?a, 1998).

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 6 ?ia?o (3 noaoo? o
iaoeiaeo aeo?iaeao oa 3 noaoo? a ca??ieeao iaoeiaeo i?aoeue).

No?oeoo?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia 160
noi??ieao ae?oeiaaiiai oaenoo, ?ethno?iaai? 10 iaethieaie oa 11
oaaeeoeyie ? neeaaeathoueny c? anooio, iaeyaeo e?oa?aoo?e, 4 ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e. Nienie aeei?enoaii? e?oa?aoo?e i?noeoue 205 aeaea?ae, c
yeeo 46 a?o/eciyieo oa 159 ca?oa?aeieo.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

A ianoaaeaiiy aoei aeeth/aii 120 oai?eo c anaioe?aeueiith
a?oa??aeueiith a?ia?oaic??th, ye? ciaoiaeeeenue ia noaoe?iia?iiio
e?eoaaii? a ea?ae?ieia?/iiio a?aeae?eaii? i?nueei? ee?i?/ii? e?ea?i? ?27
i.Oa?eiaa a ia??iae c 1996 ii 1998 ?iee.

Aeei?enoiaoaaee eeaneo?eaoe?th ??ai?a AO o aei?ineeo ? noaae?e AA ii
nooiai? iioeiaeaeaiiy i?aai?a-i?oaiae, cai?iiiiiaai?e AIIC oa
i?aeia?iaeiei oiaa?enoaii ii aea/aiith a?ia?oaic??.

Oai?eo ianoaaeoaaee i?e iinooieaii? (aei i?ecia/aiiy a?iioaiceaii?
oa?ai??) oa ia 20 aeaiue e?eoaaiiy. I?iaiaeeeinue ?ooeiia eaai?aoi?ia
ianoaaeaiiy, a oiio /ene? aecia/aiiy ai?noo aeaeo?ie?o?a e?ia? oa
neai?ioeiaiai e?aao?i?io. Aecia/aiiy ai?noo eae?y ? iao??y i?iaiaeeee a
ieaci? e?ia? (aac iayaiino? iciae aaiie?co) iaoiaeii iieoi’yii?
oioiiao??? c iiaoaeiaith eae?a?iai/ieo e?eaeo. E?aaoei?i ne?iaaoee
aecia/aee oi?o?eiaaiei iaoiaeii eieuei?iai? ?aaeoe?? ssnna ca
aeiiiiiaith iaai??a ?aaeoea?a.

?a?no?aoe?th AEA niieith i?iaiaeeee a 12 noaiaea?oieo a?aeaaaeaiiyo c
aeei?enoaiiyi i?e iaiao?aeiino? aeiaeaoeiaeo a?aeaaaeaiue.

Aeine?aeaeaiiy nei?ioeeai? caeaoiino? i?iea?aea ? ia?aiao??a
aaiiaeeiai?ee i?iaiaeeeinue iaoiaeii oeueo?acaoeiai? aoiea?ae?ia?ao?? ca
aeiiiiiaith aia?aoa OE-628 (Oe?a?ia) a I- oa A-?aaeeiao. ?ic?aoiaoaaee
iaea?eueo iieacia? aaiiaeeiai?/i? ia?aiao?e: e?ioeaai-nenoie?/iee ia’?i
(ENI), e?ioeaai-ae?anoie?/iee ia’?i (EAeI) ? o?aeoe?th aeeeaeo (OA)
e?aiai oeoii/ea (EO).

Iieacieee, ui oa?aeoa?ecothoue ooieoe?th aiaeioae?y, aecia/aee a ieaci?
e?ia? ?aae?i?ioiieia?/iei (AO-1) oa ?ioiioa?iaioiei (oeAIO) iaoiaeii ca
aeiiiiiaith a?aeiia?aeieo iaai??a. An? ?aaeoeae aeei?enoiaoaaeenue
ca?aeii ?ino?oeoe?? aeey i?iaaaeaiiy aiae?c?a.

Noaoenoe/ia ia?iaea aeaieo i?iaiaeeeanue ca?aeii i?aaee ia?iaee
iaaee/ii-a?ieia?/ii? ?ioi?iaoe?? ca aeiiiiiaith noaoenoe/ii? i?ia?aie
STATISTICA FOR WINDOWS (StatSoft, NOA). An? io?eiai? aeai? iiaeaii o
aeaeyae? na?aaeiueiai a?eoiaoe/iiai (I) eiai noaiaea?oia aeaa?aoe?y
(SD).

?acoeueoaoe aeanieo aeine?aeaeaiue

Na?aae ianoaaeaieo 120 oai?eo aoei 68 /ieia?e?a (57%) oa 52 ae?iee
(43%), na?aaei?e a?e ianoaaeaieo iaoe??io?a neeaa 51,26,1 ?iee;
na?aaeiy o?eaae?noue caoai?thaaiiy – 6,12,3 ?iee.

A caeaaeiino? a?ae ??ai?a AO i?e iinooieaii? aei noaoe?iia?o iaoe??ioe
?iciiae?eyeenue ianooiiei /eiii: i’yea AA aoea aeyaeaia o 71 iaoe??ioa
(59,2%), i?e oeueiio na?aaei? oeeo?e AO neeaee: nenoie?/iee AO 162,414,7
ii.?o.no., ae?anoie?/iee — 100,35,3 ii.?o.no.; iii??ia ? aaaeea AA
niinoa??aaeanue o 49 (40,8%) iaoe??io?a c ianooiieie na?aaei?ie oeeo?aie
AO: nenoie?/iee — 188,516,1 ii.?o.no., ae?anoie?/iee — 109,28,3
ii.?o.no.

O?eueee 14 iaoe??io?a (11,7%) iaee I noaae?th caoai?thaaiiy. O inoaii?o
a?aei?/aeenue o? aai ?io? iciaee o?aaeaiiy i?aai?a-i?oaiae ??ciiai
nooiaith ae?aaeaiino?, a?aeiia?aeii o 61 (50,8%) iaoe??ioa aoea
anoaiiaeaia II-aa oa o 45 (37,5%) iaoe??io?a – III-oy noaae?y
caoai?thaaiiy.

Oneeaaeaio niaaeeia?noue c aieo iaio aaouee?a aaeaeiny aeyaeoe o 18
(15%) iaoe??io?a, c aieo ?iaee/?a ae?oaiai nooiaiy nii??aeiaiino? – o 9
(7,5%) iaoe??io?a. Iaee??iiy ??ciiai nooiaiy aeyaeyeinue o 70,6%
/ieia?e?a (48 iaoe??io?a) oa o 63,5% ae?iie (33 iaoe??ioee). Oeoe?iaee
ae?aaao II oeio niinoa??aaany o 11 (9,2%) iaoe??io?a. Iaeeee a
oaia??oi?e /an 34 (28,3%) iaoe??ioa, 9 (7,5%) aoee iae?yie a ieioeiio.

I?e iinooieaii? a noaoe?iia? iaoe??ioe aeiaaeeiaei /eiii aoee ?icae?eai?
ia 2 a?oie: iaoe??ioai 1-? a?oie, a yeo aa?eoee 62 oai?eo, i?ecia/aee
aiaeai?eea iaeaao (?ai?oae) a ii/aoeia?e aeic? 10 ia ia aeiao, a oai?ei
2-? a?oie, a yeo aa?eoee 58 iaoe??io?a – eica?oai (Eicaa?) a ii/aoeia?e
aeic? 50 ia ia aeiao. A?oie aoee ci?anoaai? ii iniiaiei
ee?i?ei-aeaiia?ao?/iei iieacieeai. ??ai? AO a a?oi? 1 neeaee:
nenoie?/iee 177,416,8 ii.?o.no., ae?anoie?/iee — 105,28,3 ii.?o.no.; a
a?oi? 2 — nenoie?/iee — 175,715,6 ii.?o.no., ae?anoie?/iee — 106,49,7
ii.?o.no.

Ee?i?/ia aoaeoeai?noue oa aacia/i?noue oa?ai??, ui i?iaiaeeeanue,
ioe?ithaaeanue ia 5, 10, 15 oa 20 aeaiue ia?aaoaaiiy a noaoe?iia??,
aeai? i?aaenoaaeaii a oaaeeoe? 1.

?acoeueoaoe, i?aaenoaaeai? a oaaeeoe?, na?ae/aoue i?i aenieo
aoaeoeai?noue e?eoaaiiy a iaio a?oiao oai?eo. I?e oeueiio i? ii iaeiiio
c iieaciee?a, ye? aeei?enoiaoaaeenue aeey ioe?iee ee?i?/ii?
aoaeoeaiino?, ia aoei iaea?aeaii a??ia?aeieo a?aei?iiinoae i?ae a?oiaie.
A oie aea /an aacia/i?noue oa?ai?? a?ae??ciyeanue. O iaoe??io?a, ye?
io?eioaaee eica?oai, ia a?aei?io a?ae iaoe??io?a, ye? io?eioaaee
aiaeai?eea iaeaao, ia aoei a?aei?/aii eaoeth, ?icaeoeo a?ia?eae?ai??,
cia/eii? a?iioaic?? oa aia?iiaa?ioe/ieo iaa?ye?a.

Iaeiae, aiai?y/e i?i iia?/i? aoaeoe, ye? ?icaeaaeenue ia oii? i?eeiio
aiaeai?eea iaeaaoa, iio??aii i?aee?aneeoe, ui a?aei?/aia a?ia?eae?ai?y
ia aoea ee?i?/ii cia/eiith, oae? neiioiie, ye iia??oaiiy niaeo aai
cieaeaiiy aiaoeoo ia iio?aaoaaee a?aei?ie i?aia?aoa, a?iioaic?y o an?o
aeiaaeeao aoea “a?iioaic??th ia?oi? aeice”.

Iia?/i? aoaeoe, ye? iio?aaoaaee a?aei?ie i?aia?aoa, ?icaeeenue o 5
(8,1%) iaoe??io?a a a?oi? 1 oa o 1 (1,7%) iaoe??ioa a a?oi? 2,
a?aei?iiino? iaa??ia?aei?, p<0.10. Ioe?iea aacia/iino? oa?ai?? i?iaiaeeeanue oaeiae ca aeiiiiiaith aa?aaeueii-?aeoeiaiai? oeaee (A?O) e?ea?ai oa iaoe??ioii, i?e oeueiio a??ia?aeii e?aua ia?aiinei?noue i?aia?aoa a?aei?/aeanue a a?oi? iaoe??io?a, ye? io?eioaaee eica?oai. Iaeiei c aaaeeeaeo iiiaio?a e?eoaaiiy AA, ii?yae c ii?iae?caoe??th AO ? caeaoi?noue i?aia?ao?a aieeaaoe ia aiaeioae?aeueio aeenooieoe?th ? i?ioeane ?aiiaeaethaaiiy noaeei. Aea/aiiy ai?noo AO-1 iieacaei, ui eiai ??aaiue a ieaci? e?ia? caei?iaeo in?a (eiio?ieueia a?oia) neeaa 6,12,1 ia/ie i?ioe 7,12,1 ia/ie a ieaci? e?ia? oai?eo c AA (n=72), a?aei?ie a??ia?aei?, p<0.05. Oaeei /eiii, o oai?eo c AA a oe?eiio iiaeia aiai?eoe i?i aiaeioae?aeueio aeenooieoe?th c ia?aaaaith aacieiino?eeoi?iiai eaioethaa, iaeiei c iaoai?ci?a ?aae?caoe?? yeiai ? i?aeaeuaiiy ??aiy AO-1 a ieaci?. Oaaeeoey 1. Ee?i?/ia aoaeoeai?noue ? aacia/i?noue oa?ai?? aiaeai?eea iaeaaoii ? eica?oaiii o oai?eo AA. IieacieeeA?oia 1 (n=62)A?oia 2 (n=58)AAe neno (MD), ia 20-e aeaiue 150,18,4 ii.?o.no.*149,37,5 ii.?o.no.*AAe ae?ano (MD), ia 20-e aeaiue90,33,2 ii.?o.no.*89,43,8 ii.?o.no.*Ii?iae?caoe?y ??aiae AAe neno, n (%), ia 20-e aeaiue AAe ae?ano n (%), ia 20-e aeaiue 49 (79) 51 (82,3) 47 (81) 50 (86,2)I?aeaeuaiiy aeice a i?ioean? e?eoaaiiy, n (%) 31 (50) 29 (50)Aeiaeaoeiaa i?ecia/aiiy aioea?ia?oaiceaieo i?aia?ao?a, n, % 13 (21) 16 (27,6)Ioe?iea aoaeoeaiino? e?eoaaiiy ii A?O e?ea?ai - aeia?a, n, % - caaeia?eueia n, % 41 (66,1) 21 (33,9) 38 (82,8) 21 (33,9)Ioe?iea aoaeoeaiino? e?eoaaiiy ii A?O iaoe??ioii - aeia?a, n, % - caaeia?eueia n, % - iacaaeia?eueia n, % 49 (66,1) 12 (19,4) 1 (1,6) 48 (82,2) 10 (17,2) -E?euee?noue iia?/ieo aoaeo?a, n, %16 (25,8)6 (10,3) †Ioe?iea aacia/iino? e?eoaaiiy ii A?O e?ea?ai - aeia?a, n, % - caaeia?eueia n, % - iacaaeia?eueia n, % 42 (67,7) 15 (24,2) 5 (8,1) 52 (89,7) ‡ 5 (9,6) † 1 (1,7)Ioe?iea aacia/iino? e?eoaaiiy ii A?O iaoe??ioii - aeia?a, n, % - caaeia?eueia n, % - iacaaeia?eueia n, % 44 (71) 13 (21) 5 (8) 50 (86,2) † 7 (12,1) 1 (1,7)I?ei?oee: 1. A?O – a?coaeueii-?aeoeiaiaa oeaea. 2. * - p<0.001 a ii??aiyii? c aeaieie aei e?eoaaiiy; † - p<0.05 i?e ii??aiyii? ?acoeueoao?a i?ae a?oiaie; ‡ - p<0.01 i?e ii??aiyii? ?acoeueoao?a i?ae a?oiaie. O?eaae?noue ia?aa?ao caoai?thaaiiy aaaaoi a /iio aecia/a? noai aiaeioae?th noaeei ? o?aaeaiiy i?aai?a-i?oaiae. Aiae?c eiioeaio?aoe?? AO-1 a ieaci? a caeaaeiino? a?ae o?eaaeino? caoai?thaaiiy iieacaa, ui o iaoe??io?a c o?eaae?noth oai?iae iaioa 1 ?ieo (n=11) ??aaiue AO-1 neeaa 6,32,1 ia/ie, ui cia/eii ia a?ae??ciyeinue a?ae eiio?ieueieo cia/aiue (p>0.20). O iaoe??io?a c o?eaae?noth AA a?ae 1 ?ieo aei 5 ?ie?a (n=38)
ai?no AO-1 aoa 7,92,4 ia/ie, ui aoei aeinoia??ii aeua, /ei a eiio?ie?
(p<0.01), aea a??ia?aeii ia a?ae??ciyeinue a?ae cia/aiue a a?oi? iaoe??io?a c o?eaae?noth AA iaioa 1 ?ieo (p<0.10). Iaoe??ioe c o?eaae?noth caoai?thaaiiy a?eueoa 5 ?ie?a iaee ??aaiue AO-1 9,73,0 ia/ie, ui aoei ia o?eueee a??ia?aeii aeua, /ei a eiio?ie? (p<0.001), aea ? a a?oi? oai?eo c o?eaae?noth AA iaioa 1 ?ieo (p<0.01) oa n o?eaae?noth AA a?ae 1 ?ieo aei 5 ?ie?a (p<0.01). Ai?no oeAIO (aoi?eiiiai ianaiaeaea?a NO) a eiio?ieuei?e a?oi? neeaa 6,91,6 iiieue/e, a a a?oi? oai?eo c AA a oe?eiio - 6,71,9 iiieue/e, a?aei?ie iaa??ia?aei? (p>0.20).

Aiae?c i?aea?oi iieacaa, ui i?e a?aenooiino? aeinoia??ieo a?aei?i i?ae
eiio?ieueiith a?oiith oa a?oiith oai?eo c AA a oe?eiio o iaoe??io?a c
o?eaae?noth caoai?thaaiiy aei 1 ?ieo (n=11) ??aaiue oeAIO a??ia?aeii
i?aeaeuoaaany — 9,42,7 iiieue/e, p<0.01. I?e o?eaaeino? caoai?thaaiiy a?ae 1 ?ieo aei 5 ?ie?a (n=38) eiioeaio?aoe?y oeAIO neeaea 7,71,9 iiieue/e, cia/eii ia a?ae??ciyth/enue a?ae oaei? a a?oi? eiio?ieth (p<0.10), a oie aea /an a??ia?aeii cieaeoth/enue a ii??aiyii? c a?oiith iaoe??io?a c o?eaae?noth caoai?thaaiiy iaioa 1 ?ieo (p<0.05). O iaoe??io?a c o?eaae?noth caoai?thaaiiy a?eueoa 5 ?ie?a ??aaiue oeAIO ??aiyany 5,41,2 iiieue/e, ui aoei ia o?eueee aeinoia??ii ieae/a, /ei a a?oiao c o?eaae?noth caoai?thaaiiy iaioa 1 ?ieo (p<0.001) ? a?ae 1 ?ieo aei 5 ?ie?a (p<0.001), aea ? ieae/a, i?ae a a?oi? eiio?ieth (p<0.001). A ca’yceo c oei, ui a iaoiaaiac? AA i?ia?aeia ?ieue iaeaaeeoue ii?ooaiith ni?aa?aeiioaiiy aaciaeeeaoaoi?ieo oa aacieiino?eeoi?ieo iaoai?ci?a, iaie aoei aeiaeaoeiai i?iaiae?ciaaii ni?aa?aeiioaiiy AO-1/oeAIO, yea neeaei a eiio?ieuei?e a?oi? 0,910,28, a a a?oi? oai?eo c AA - 1,10,31, ui aoei a??ia?aeii aeua, /ei a a?oi? eiio?ieth. O iaoe??io?a c o?eaae?noth caoai?thaaiiy iaioa 1 ?ieo oea a?aeiioaiiy neeaei 0,710,19, ui aoei a??ia?aeii ieae/a, /ei a eiio?ie? (p<0.05). Oaea cieaeaiiy aeaiiai a?aeiioaiiy na?ae/eoue i?i ia?aaaao aaciaeeeaoaoi?ieo iaoai?ci?a a ii/aoeia?e noaae?? caoai?thaaiiy oa i?i iayai?noue oa caaeia?eueiee noai eiiiainaoi?ieo iaoai?ci?a ia ?aii?o noaae?yo caoai?thaaiiy. I?e o?eaaeino? caoai?thaaiiy a?ae 1 ?ieo aei 5 ?ie?a a?aeiioaiiy AO-1/oeAIO a??ia?aeii i?aeaeuo?oueny ia o?eueee a ii??aiyii? c a?oiith iaoe??io?a c o?eaae?noth caoai?thaaiiy aei 1 ?ieo (p<0.001), aea ? a ii??aiyii? c eiio?ieueiith a?oiith (p<0.01) ? noaiiaeoue 1,090,22. I?iaaaeaiee a iiaeaeueoiio aiae?c i?aea?oi iieacaa, ui o oai?eo c I noaae??th (n=11) caoai?thaaiiy (iciaee o?aaeaiiy i?aai?a-i?oaiae a?aenooi?) ??aaiue AO-1 neeaa 6,82,2 ia/ie, a??ia?aeii ia a?ae??ciyth/enue a?ae cia/aiue a a?oi? eiio?ieth (p>0.20). O oai?eo c II
(n=34) noaae??th AA (aeyaeythoueny iciaee o?aaeaiiy i?aai?a-i?oaiae) —
8,62,5 ia/ie, ui aoei a??ia?aeii aeua, /ei a eiio?ie? (p<0.001) ? a a?oi? iaoe??io?a c I noaae??th caoai?thaaiiy (p<0.05). I?e III noaae?? caoai?thaaiiy (n=27) niinoa??aa?oueny iiaeaeueoa i?aeaeuaiiy ??aiy AO-1 aei 9,32,8 ia/ie, ui a??ia?aeii a?ae??ciy?oueny c ai?noii AO-1 a ieaci? ye a a?oi? eiio?ieth (p<0.001), oae ? a a?oi? iaoe??io?a c I noaae??th caoai?thaaiiy (p<0.02). Oaiaeaioe?y aei iiaeaeueoiai i?aeaeuaiiy ??aiy AO-1 i?e III noaae?? caoai?thaaiiy ia aeinyaea noaoenoe/ii cia/eieo a?aei?i. Ai?no oeAIO i?e I noaae?? caoai?thaaiiy neeaa 7,62,1 iiieue/e, ui i?e aeaye?e oaiaeaioe?? aei i?aeaeuaiiy a ii??aiyii? c eiio?ieueiith a?oiith ia aeinyaei noaoenoe/ii a??ia?aeieo a?aei?i (p>0.20), oiae? ye i?e II
noaae?? caoai?thaaiiy ??aaiue oeAIO cia/eii cieaeoaaany – aei 6,01,9
iiieue/e – ia o?eueee a ii??aiyii? c a?oiith iaoe??io?a c I-th noaae??th
caoai?thaaiiy (p<0.05), aea ? a ii??aiyii? c a?oiith eiio?ieth (p<0.05). I?e III noaae?? caoai?thaaiiy eiioeaio?aoe?y oeAIO i?iaeiaaeo? cieaeoaaoeny ? neeaaea? 5,51,2 iiieue/e, ui a??ia?aeii ieae/a, /ei a a?oi? eiio?ieth (p<0.001) ? a a?oi? iaoe??io?a c I-th noaae??th caoai?thaaiiy (p<0.02), iaeiae cia/ii ia a?ae??ciy?oueny a?ae cia/aiue o iaoe??io?a c II-th noaae??th AA (p>0.20).

A?aeiioaiiy AO-1/oeAIO i?e I-e noaae?? oai?iae neeaei 0,880,19, ui ia
a?ae??ciyeinue a??ia?aeii a?ae eiio?ieueii? a?oie. I?e II-e noaae?? oea
a?aeiioaiiy aeinoia??ii c?inoa? aei 1,390,39, ye a ii??aiyii? c
eiio?ieueiith a?oiith (p<0.001), oae ? a ii??aiyii? c a?oiith iaoe??io?a c I-th noaae??th oai?iae (p<0.001). O iaoe??io?a c III-th noaae??th caoai?thaaiiy oea a?aeiioaiiy ua a?eueo i?aeaeuo?oueny - 1,650,48, ui a??ia?aeii a?ae??ciy?oueny a?ae a?oie eiio?ieth oa a?oie c I-th noaae??th oai?iae (p<0.001), a oaeiae a?ae a?oie iaoe??io?a c II-th noaae??th caoai?thaaiiy (p<0.05). Aiae?c ai?noo AO-1 c i’yeith AA (n=42) iieacaa iayai?noue oaiaeaioe?? aei i?aeaeuaiiy ??aiy AO-1 (?en.1) a ieaci? e?ia? - 6,82,8 ia/ie, iaeiae oe? a?aei?ie ia yaeythoueny noaoenoe/ii cia/eieie a ii??aiyii? c a?oiith eiio?ieth (p>0.20). Eiioeaio?aoe?y AO-1 a ieaci? e?ia? iaoe??io?a c
iii??iith oa aaaeeith AA (n=30) neeaea 8,43,6 ia/ie. Oe? cia/aiiy aoee
a??ia?aeii aeueie ia o?eueee a ii??aiyii? c a?oiith eiio?ieth (p<0.01), aea ? a ii??aiyii? c aeaieie, ye? aoei io?eiaii a a?oi? I (p<0.05). ’ wmetafile8010009000003fc0800000b0035000000000005000000090200000000050000 000102ffffff000400000004010d000400000002010200050000000c024301e201030000 001e00040000002701ffff030000001e00040000002701ffff050000000b020000000003 0000001e00050000000102ffffff000500000009020000000015000000fb02e8ff000000 000000bc02000000cc0000001254696d6573204e657720526f6d616e00cc00040000002d 01000010000000fb02edff000000000000bc02000000cc00000022417269616c00cc0004 0000002d010100040000002d010000040000002d01010010000000fb0210000700000000 00bc02000000cc0102022253797374656d00cc040000002d010200040000002701ffff03 0000001e00040000002d010100050000000102ffffff0005000000090200000000070000 0016044301e20100000000040000002d010200040000002701ffff030000001e00040000 002d010100050000000102ffffff00050000000902000000000700000016044301e20100 0000000700000015047b00d90145008301040000002d010200040000002701ffff030000 001e00040000002d010100050000000102ffffff00050000000902000000000700000016 044301e20100000000040000002d010200040000002701ffff030000001e00040000002d 010100050000000102ffffff00050000000902000000000700000016043f01de01040004 00040000002d010200040000002701ffff030000001e00040000002d0101000500000001 02ffffff00050000000902000000000700000016041b01760120002e00040000002d0102 00040000002701ffff030000001e00040000002d010100050000000102ffffff00050000 000902000000000700000016041a0177011e002e0009000000fa02000001000000000000 002200040000002d01030007000000fc020000000000000000040000002d010400050000 000902ffffff00050000000102000000000400000004010d0004000000020102000e0000 002403050046007100650071006500190146001901460071000e00000024030500b2005e 00d2005e00d2001901b2001901b2005e000e000000240305001f0132003e0132003e0119 011f0119011f0132000800000026060f000600ffffffff000009000000fa020500000000 00ffffff002200040000002d01050007000000fc020100000000000000040000002d0106 000400000007010400050000000102ffffff000500000009020000000035000000420105 000000280000000800000008000000010001000000000020000000c40e0000c40e000002 0000000200000000000000ffffff003366666699333333cc99999966cccccc3366666699 333333cc99999966cccccc0a30333d30330d0a464c41472330333d040000002d01070004 0000002d010700090000001d062100f000bf001f005a006500040000002d010700050000 0009020100000005000000010201000000040000002d01060004000000f0010700040000 002d010300040000002d01040004000000070101000800000026060f000600ffffffff01 0007000000fc020100000000008020040000002d0107000e0000002403050065005a0084 005a00840019016500190165005a00040000002d01040004000000f00107000800000026 060f000600ffffffff0000040000002d010500040000002d010600040000000701040005 0000000102ffffff00050000000902000000003500000042010500000028000000080000 0008000000010001000000000020000000c40e0000c40e00000200000002000000000000 00ffffff0099666666cc3333336699999933cccccc99666666cc3333336699999933cccc ccc304f7d81bc023c35057e8498e000057040000002d010700040000002d010700090000 001d062100f000c1001f005800d200040000002d01070005000000090201000000050000 00010201000000040000002d01060004000000f0010700040000002d010300040000002d 01040004000000070101000800000026060f000600ffffffff010007000000fc02010000 0000008020040000002d0107000e00000024030500d2005800f1005800f1001901d20019 01d2005800040000002d01040004000000f00107000800000026060f000600ffffffff00 00040000002d010500040000002d0106000400000007010400050000000102ffffff0005 000000090200000000350000004201050000002800000008000000080000000100010000 00000020000000c40e0000c40e0000020000000200000000000000ffffff0099666666cc 3333336699999933cccccc99666666cc3333336699999933ccccccc304f7d81bc023c350 57e8498e000057040000002d010700040000002d010700090000001d062100f0009e001f 007b003e01040000002d0107000500000009020100000005000000010201000000040000 002d01060004000000f0010700040000002d010300040000002d01040004000000070101 000800000026060f000600ffffffff010007000000fc020100000000008020040000002d 0107000e000000240305003e017b005d017b005d0119013e0119013e017b00040000002d 01040004000000f001070009000000fa02000000000000000000002200040000002d0107 0007000000fc020000ffffff000000040000002d010800040000002d0102000400000027 01ffff030000001e00040000002d010100040000002d010400040000002d010300050000 00010200000000050000000902ffffff000700000016041b01760120002e00040000002d 010700040000002d010800040000002d010200040000002701ffff030000001e00040000 002d010100040000002d010400040000002d010300050000000102000000000500000009 02ffffff000700000016044301e2010000000009000000fa020000010000000000000022 00040000002d01090004000000f001030005000000140221002f00050000000102ffffff 000400000004010d00040000000201010005000000130219012f00050000001402190129 0005000000130219012f00050000001402fd002900050000001302fd002f000500000014 02e2002900050000001302e2002f00050000001402c6002900050000001302c6002f0005 0000001402ab002900050000001302ab002f000500000014028f0029000500000013028f 002f000500000014027400290005000000130274002f0005000000140258002900050000 00130258002f000500000014023d0029000500000013023d002f00050000001402210029 0005000000130221002f0005000000140219012f0005000000130219017401040000002d 01000005000000140220012f0005000000130219012f0005000000140220019b00050000 00130219019b000500000014022001080105000000130219010801050000001402200174 0105000000130219017401040000002d010700040000002d010800040000002d01020004 0000002701ffff030000001e00040000002d010000040000002d010400040000002d0109 00050000000102ffffff00050000000902ffffff000700000016044301e2010000000004 0000002d010100040000002d010700040000002d010800040000002d0102000400000027 01ffff030000001e00040000002d010100040000002d010400040000002d010900050000 000102ffffff00050000000902ffffff000700000016044401e301ffffffff0500000009 02000000000400000004010d00040000000201010009000000320a0e0115000100000030 000b0009000000320af20015000100000031000b0009000000320ad70015000100000032 000b0009000000320abb0015000100000033000b0009000000320aa00015000100000034 000b0009000000320a840015000100000035000b0009000000320a690015000100000036 000b0009000000320a4d0015000100000037000b0009000000320a320015000100000038 000b0009000000320a160015000100000039000b00040000002d010700040000002d0108 00040000002d010200040000002701ffff030000001e00040000002d010100040000002d 010400040000002d010900050000000102ffffff00050000000902000000000700000016 044301e20100000000040000002d010000040000002d010700040000002d010800040000 002d010200040000002701ffff030000001e00040000002d010000040000002d01040004 0000002d010900050000000102ffffff00050000000902000000000700000016044401e3 01ffffffff040000002d010700040000002d010800040000002d010200040000002701ff ff030000001e00040000002d010000040000002d010400040000002d0109000500000001 02ffffff00050000000902000000000700000016044301e20100000000040000002d0101 0007000000fc020100000000008020040000002d0103000400000004010d000400000002 010200070000001b047c00d90145008301040000002d010700040000002d010800040000 002d010200040000002701ffff030000001e00040000002d010100040000002d01030004 0000002d010900050000000102ffffff00050000000902000000000700000016047b00d9 0145008301040000002d010700040000002d010800040000002d010200040000002701ff ff030000001e00040000002d010100040000002d010300040000002d0109000500000001 02ffffff00050000000902000000000700000016047b00d9014500830109000000fa0200 0001000000000000002200040000002d010a0004000000f0010900040000002d01040004 000000f0010300050000000902ffffff00050000000102000000000400000004010d0004 00000002010200070000001b045b0095014f008901050000000902000000000500000001 02ffffff000400000002010100040000002e01180009000000320a5b009a0104000000c5 d22d31040000002e010000040000002d010700040000002d010800040000002d01020004 0000002701ffff030000001e00040000002d010100040000002d010400040000002d010a 00050000000102ffffff00050000000902000000000700000016047b00d9014500830104 0000002d010700040000002d010800040000002d010200040000002701ffff030000001e 00040000002d010100040000002d010400040000002d010a00050000000102ffffff0005 0000000902000000000700000016047b00d9014500830109000000fa0200000100000000 0000002200040000002d01030004000000f0010a000800000026060f000600ffffffff00 00040000002d010500040000002d0106000400000007010400050000000102ffffff0005 000000090200000000350000004201050000002800000008000000080000000100010000 00000020000000c40e0000c40e0000020000000200000000000000ffffff003366666699 333333cc99999966cccccc3366666699333333cc99999966cccccc0a33363d2a31350d0a 464c4147232a31040000002d010900040000002d010900090000001d062100f0000b000b 006a008901040000002d0109000500000009020100000005000000010201000000040000 002d01060004000000f0010900040000002d010300040000002d01040004000000070101 000800000026060f000600ffffffff010007000000fc020100000000008020040000002d 010900050000000102000000000400000004010d000400000002010200070000001b0476 0095016a008901040000002d01040004000000f0010900050000000102ffffff00040000 0002010100040000002e01180009000000320a76009a0104000000f6c3ccd4040000002e 010000040000002d010700040000002d010800040000002d010200040000002701ffff03 0000001e00040000002d010100040000002d010400040000002d010300050000000102ff ffff00050000000902000000000700000016047b00d90145008301040000002d01070004 0000002d010800040000002d010200040000002701ffff030000001e00040000002d0101 00040000002d010400040000002d010300050000000102ffffff00050000000902000000 000700000016044301e20100000000040000002d010400040000002d01070004000000f0 010300040000002701ffff050000000c024301e201030000001e00050000000102ffffff 0005000000090200000000040000002701ffff050000000b0200000000030000001e0005 0000000102ffffff0005000000090200000000040000002701ffff030000000000000000 000000000000fffffff0ee3c006400874e00000000000000000000000000000000000000 00 ’ wmetafile801000900000349040000080015000000000005000000090200000000050000 000102ffffff000400000004010d000400000002010200050000000c024001e001030000 001e00040000002701ffff030000001e00040000002701ffff050000000b020000000003 0000001e00050000000102ffffff000500000009020000000015000000fb02e8ff000000 000000bc02000000cc0000001254696d6573204e657720526f6d616e00cc00040000002d 01000010000000fb02edff000000000000bc02000000cc00000022417269616c00cc0004 0000002d010100040000002d01000010000000fb021000070000000000bc02000000cc01 02022253797374656d00cc040000002d010200040000002701ffff030000001e00040000 002d010000050000000102ffffff00050000000902000000000700000016044001e00100 000000040000002d010200040000002701ffff030000001e00040000002d010000050000 000102ffffff00050000000902000000000700000016044001e00100000000040000002d 010200040000002701ffff030000001e00040000002d010000050000000102ffffff0005 0000000902000000000700000016043c01dc0104000400040000002d0102000400000027 01ffff030000001e00040000002d010000050000000102ffffff00050000000902000000 000700000016041901740120002d00040000002d010200040000002701ffff030000001e 00040000002d010000050000000102ffffff000500000009020000000007000000160418 0175011e002d0009000000fa02000001000000000000002200040000002d010300070000 00fc020000000000000000040000002d010400050000000902ffffff0005000000010200 0000000400000004010d0004000000020102000e000000240305004e0070007900700079 0017014e0017014e0070000e00000024030500ba005d00e5005d00e5001701ba001701ba 005d000e00000024030500260131005101310051011701260117012601310009000000fa 02000000000000000000002200040000002d01050007000000fc020000ffffff00000004 0000002d010600040000002d010200040000002701ffff030000001e00040000002d0100 00040000002d010400040000002d01030005000000010200000000050000000902ffffff 000700000016041901740120002d00040000002d010500040000002d010600040000002d 010200040000002701ffff030000001e00040000002d010000040000002d010400040000 002d01030005000000010200000000050000000902ffffff000700000016044001e00100 00000009000000fa02000001000000000000002200040000002d01070004000000f00103 0005000000140221002e00050000000102ffffff000400000004010d0004000000020101 0005000000130217012e00040000002d0101000500000014021701280005000000130217 012e00050000001402fc002800050000001302fc002e00050000001402e0002800050000 001302e0002e00050000001402c5002800050000001302c5002e00050000001402aa0028 00050000001302aa002e000500000014028e0028000500000013028e002e000500000014 027300280005000000130273002e000500000014025800280005000000130258002e0005 00000014023c0028000500000013023c002e000500000014022100280005000000130221 002e0005000000140217012e0005000000130217017201040000002d0100000500000014 021e012e0005000000130217012e000500000014021e019a0005000000130217019a0005 00000014021e010601050000001302170106010500000014021e01720105000000130217 017201040000002d010500040000002d010600040000002d010200040000002701ffff03 0000001e00040000002d010000040000002d010400040000002d010700050000000102ff ffff00050000000902ffffff000700000016044001e00100000000040000002d01010004 0000002d010500040000002d010600040000002d010200040000002701ffff030000001e 00040000002d010100040000002d010400040000002d010700050000000102ffffff0005 0000000902ffffff000700000016044101e101ffffffff05000000090200000000040000 0004010d00040000000201010009000000320a0c0114000100000030000b000900000032 0af10014000100000031000b0009000000320ad50014000100000032000b000900000032 0aba0014000100000033000b0009000000320a9f0014000100000034000b000900000032 0a830014000100000035000b0009000000320a680014000100000036000b000900000032 0a4d0014000100000037000b0009000000320a310014000100000038000b000900000032 0a160014000100000039000b00040000002d010500040000002d010600040000002d0102 00040000002701ffff030000001e00040000002d010100040000002d010400040000002d 010700050000000102ffffff00050000000902000000000700000016044001e001000000 00040000002d010000040000002d010500040000002d010600040000002d010200040000 002701ffff030000001e00040000002d010000040000002d010400040000002d01070005 0000000102ffffff00050000000902000000000700000016044101e101ffffffff040000 002d010500040000002d010600040000002d010200040000002701ffff030000001e0004 0000002d010000040000002d010400040000002d010700050000000102ffffff00050000 000902000000000700000016044001e00100000000040000002d010400040000002d0105 0004000000f0010700040000002701ffff050000000c024001e001030000001e00050000 000102ffffff0005000000090200000000040000002701ffff050000000b020000000003 0000001e00050000000102ffffff0005000000090200000000040000002701ffff030000 00000000000000000000000a001e00294000000000000000000000000000000000000000 00000000000000000000000000 Ai?no oeAIO, a naith /a?ao, o iaoe??io?a c i’yeith AA ia a?ae??ciyany a?ae eiio?ieueii? a?oie ? neeaa 7,02,3 iiieue/e, a o iaoe??io?a c iii??iith oa aaaeeith AA - 5,71,8 iiieue/e, ui aoei a??ia?aeii ieae/a, /ei a a?oi? eiio?ieth (p<0.01). Ni?aa?aeiioaiiy AO-1/oeAIO o iaoe??io?a c i’yeith AA neeaei 0,930,21 (?en.2), a o iaoe??io?a c iii??iith oa aaaeeith AA – 1,420,33, a?aei?ie i?ae a?oiaie a??ia?aei?, p<0.001. A ?acoeueoao? i?iaaaeaiiai ei?aeyoe?eiiai aiae?co i?ae ??aiyie AO-1 ? AO aoei aeyaeaii iiceoeaiee ei?aeyoe?eiee ca’ycie: i?ae ??aiai AO-1 ? nenoie?/iei AO (r=0.72, p<0.001) e iiae?aia, oi/ ? ia oaea neeueia ei?aeyoe?eia caeaaei?noue) i?ae ??aiyie AO-1 oa ae?anoie?/iei AO (r=0.61, p<0.02). I?iaaaeaiee ei?aeyoe?eiee aiae?c ia iieacaa caeaaeiino? ai?noo oeAIO a?ae AO a ianoaaeai?e a?oi? iaoe??io?a a oe?eiio (r=-0.26, p<0.20 aeey nenoie?/iiai AO ? r=-28, p<0.10 aeey ae?anoie?/iiai AO). A oie aea /an ei?aeyoe?eiee aiae?c, i?iaaaeaiee a a?oiao oai?eo c ??ciith o?eaae?noth caoai?thaaiiy iieacaa, ui a a?oi? iaoe??io?a c aeaai?noth AA aei 1 ?ieo ??aaiue oeAIO i?yii ei?aethaaa c ??aiai AO – nenoie?/iiai c r=0.54, p<0.05 ? ae?anoie?/iiai – c r=0.68, p<0.01. O iaoe??io?a c o?eaae?noth caoai?thaaiiy a?eueoa 5 ?ie?a niinoa??aaeanue cai?ioiy ei?aeyoe?eia caeaaei?noue i?ae ??aiyie oeAIO ? AO – aeey nenoie?/iiai r=-0.49, p<0.05 ? aeey ae?anoie?/iiai - r=-0.59, p<0.02. Aeeiai?eo iieaciee?a, ui aea/aeenue, a i?ioean? e?eoaaiiy i?aaenoaaeaii a oaaeeoe? 2. Oaaeeoey 2. Aeeiai?ea iieaciee?a, ye? oa?aeoa?ecothoue ooieoe?th aiaeioae?y o oai?eo AA a i?ioean? e?eoaaiiy (MSD). IieacieeA?oia 1 (n=38)A?oia 2 (n=34)aei e?eoaaiiyi?ney e?eoaaiiyaei e?eoaaiiyi?ney e?eoaaiiyAO-1 (ia/ie)7,082,236,342,017,192,296,642,13OeAIO (iiieue/e)6,591,996,862,336,732,096,892,26AO-1/oeAIO1,090,310,910,19**1, 070,240,940,17* I?ei?oee: * - p < 0.02, ** - p<0.01 i?e ii??aiyii? ?acoeueoao?a c aeaieie aei e?eoaaiiy. sse ne?aeo? c ?acoeueoao?a, ui i?eaaaeaii a oaaeeoe?, a iaio a?oiao i?ney e?eoaaiiy a?aei?/aeanue oaiaeaioe?y aei cieaeaiiy ??aiy AO-1 ? i?aeaeuaiiy ??aiy oeAIO. Iaeiae, a??ia?aei? a?aei?ie aoei io?eiaii i?e aea/aii? a?aeiioaiiy AO-1/oeAIO, yea oa?aeoa?eco? ca’ycie i?ae i?iaeoeoe??th aacieiino?eeoi?ieo ? aaciaeeeaoaoe?eieo noanoaioe?e. Oaeei /eiii, aeieaoi?e ?ai?i-aia?ioaiceiiai? nenoaie – ?i?a?a?oi? aia?ioaiceiia?aoai?thth/iai oa?iaioo aiaeai?ee oa aioaaii?no ?aoeaioi??a aia?ioaiceia II eica?oai – ciaiooaaee nooi?iue aiaeioae?aeueii? aeenooieoe??. Iaeiae, a??ia?aei?noue io?eiaieo ?acoeueoao?a aoea aeuith a a?oi? iaoe??io?a, ye? e?eoaaeenue aiaeai?eeii. Aea/aiiy aieeao oa?ai??, ui i?iaiaeeeanue, ia iieacieee AEA ioe?ithaaeinue ia i?aenoaa? aeeiai?ee e?ioeaai? /anoeie oeoii/eiaiai eiiieaena. Oae, cieaeaiiy naaiaioa ST a 1-e a?oi? aei e?eoaaiiy a?aei?/aeinue o 9 (14,5%) iaoe??io?a, i?ney e?eoaaiiy – o 6 (9,7%), i?e oeueiio e?euee?noue a?aeaaaeaiue ia iaeiiai oai?iai a?aeiia?aeii neeaea 3,20,6 ? 1,40,3 (p<0.01). A a?oi? 2 cieaeaiiy naaiaioa ST aei e?eoaaiiy aoei ca?a?no?iaaii o 8 (13,8%) iaoe??io?a, a i?ney e?eoaaiiy – o 6 (10,3%). E?euee?noue a?aeaaaeaiue ia iaeiiai oai?iai i?e oeueiio neeaea 3,40,7 i?ioe 2,10,5 (p<0.01 i?e ii??aiyii? aeaieo aei ? i?ney e?eoaaiiy, p<0.01 i?e ii??aiyii? aeaieo i?ae a?oiaie). ?iaa?n?y coaoey O aei e?eoaaiiy niinoa??aaeanue a a?oi? 1 o 5 (8,1%) iaoe??io?a, i?ney e?eoaaiiy – 2 (3,2%), e?euee?noue a?aeaaaeaiue ia iaeiiai oai?iai i?e oeueiio neeaea 2,90,4 i?ioe 0,90,2 (p<0.01). A a?oi? 2 e?euee?noue oai?eo c ?iaa?n??th coaoey O cia/iei /eiii ia ci?ieeinue – 4 (6,9%) i?ioe 2 (3,4%), oae aea, ye ? e?euee?noue a?aeaaaeaiue ia iaeiiai oai?iai - 2,70,5 i?ioe 1,70,4. Aeey ioe?iee aieeao oa?ai?? ia i?iaiic caoai?thaaiiy iaie aoea aea?aia oeaea i?iea?ae?aeueiiai iioeiaeaeaiiy CIIS (a?ae aia. Cardiac Infarction Injury Score), aeniea ?ioi?iaoeai?noue yei? o oai?eo c AA aoea iieacaia P.M.Rautaharja et al., 1987. Na?aaei? cia/aiiy CIIS o an?e a?oi? iaoe??io?a c AA neeaee 17,43,4. I?e oeueiio a a?oiao oai?eo, ye? io?eioaaee aiaeai?ee aai eica?oai, aei ii/aoeo e?eoaaiiy oe? cia/aiiy neeaee 16,94,1 oa 17,84,3 (a?aei?ie ia a??ia?aei?, p>0.20). I?ney eo?no e?eoaaiiy a a?oi? iaoe??io?a, ye?
io?eioaaee aiaeai?ee, niinoa??aaeanue oaiaeaioe?y aei cieaeaiiy aeaiiai
iieacieea a ii??aiyii? c aeaieie aei e?eoaaiiy aei 15,45,1, yea ia
aeinyaea noaoenoe/ii aeinoia??ieo a?aei?i. A oie aea /an a a?oi?
iaoe??io?a, ye? io?eioaaee eica?oai, cieaeaiiy aeaiiai iieacieea aoei
a??ia?aeiei — 15,94,9 (p<0.05). Oaeei /eiii, ?ecee eaoaeueiiai aeoiaeo a?ae na?oeaai-noaeeiieo i?e/ei a??ia?aeii cieaeoaaany a a?oi? iaoe??io?a, ye? io?eioaaee eica?oai, ia a?aei?io a?ae a?oie iaoe??io?a, ye? e?eoaaeenue aiaeai?eeii, aea oea cieaeaiiy iineei eeoa oa?aeoa? oaiaeaioe??. A ??ciiiai?oiiio o?aaeaii? i?aai?a-i?oaiae i?e AA na?oeth a?aeaiaeeoueny iniaeeaa oaaaa ia o?eueee ye aeeoo?ai aaaeeeaiio i?aaio, aea e c o?aooaaiiyi /anoioe o?aaeaiiy – iaeaea 70% iaoe??io?a c AA iathoue o?aaeaiiy na?oey. ?nioaaaoa o?eaaeee /an iiiyooy “a?ia?oii?/ia na?oea” oa a?eueo oi/ia “?aiiaeaethaaiiy na?oey”, yea cai?iiiiiaaii a inoaii? ?iee, ia’?aeiothoue eiiieaeni? ii?oieia?/i? oa no?oeoo?i? ci?ie e?aeo a?aeae?e?a na?oey (a ia?oo /a?ao e?aiai oeoii/ea), ye? i?iaiaeyoue aei ?o a?ia?o?io?? ? aeeeaoaoe?? ii?iaeiei, ui noa? i?e/eiith ?icaeoeo NI ? ? oaeoi?ii ?eceeo ?icaeoeo na?oeaai-noaeeiieo oneeaaeiaiue, aeeth/ath/e ?aioiao nia?oue. A oeueiio ca’yceo ie??i aeeiai?ee AEA iaie aoei i?iaiae?ciaai? ci?ie aaiiaeeiai?/ieo iieaciee?a a i?ioean? e?eoaaiiy aiaeai?eeii ? eica?oaiii (oaaeeoey 3). Oaaeeoey 3. Ci?ie aaiiaeeiai?/ieo iieaciee?a i?ae aieeaii oa?ai?? aiaeai?eea iaeaaoii ? eica?oaiii (MSD). IieacieeeA?oia 1 (n=62)A?oia 2 (n=58)Aei e?eoaaiiy i?ney e?eoaaiiy aei e?eoaaiiy i?ney e?eoaaiiy EAeI, ie133,78,7130,57,9*134,18,4130,98,7*ENI, ie50,95,949,15,351,36,149,65,9OA, %62,44,162,84,961,94,862,45,1CIIN, aeei/n/ci-5147365142371†149485146191*‡ I?ei?oee: * - p < 0.05, † - p<0.001 i?e ii??aiyii? ?acoeueoao?a aei ? i?ney e?eoaaiiy, ‡ - p<0.01 i?e ii??aiyii? ?acoeueoao?a i?ae a?oiaie. Aea?ai? iaie aeey aiae?co iieacieee a?aeia?aaeothoue aieea i?aia?ao?a ia ia?aaeiaaaioaaeaiiy (EAeI) ? i?neyiaaaioaaeaiiy (caaaeueiee ia?eoa?e/iee ii?? noaeei – CIIN). A?aeiia?aeii iiaeia aiai?eoe i?i oa, ui e?eoaaiiy oai?eo c AA ?ia?a?oi?aie AIO aai aioaaii?noaie ?aoeaioi??a aia?ioaiceia II ni?eyoeeai aieeaa? ia no?oeoo?ii-ooieoe?iiaeueiee noai na?oey ca ?aooiie cieaeaiiy ia?aae- oa i?neyiaaaioaaeaiiy. Oeae aieea i?iyaey?oueny aaea a ia?o? oeaei? e?eoaaiiy, i?e oeueiio i?ecia/aiiy ?ia?a?oi??a AIO a ii??aiyii? c aioaaii?noaie ?aoeaioi??a aia?ioaiceia II i?eaiaeeoue aei a?eueoiai cieaeaiiy i?neyiaaaioaaeaiiy. Cieaeaiiy CIIN ? aaaeeeaei oaeoi?ii caiia?aaiiy ?aiiaeaethaaiith noaeei. Iaea?eueo? ci?ie a?aei?/aii naia c aieo CIIN. A i?ioean? e?eoaaiiy a?aeaoaaeiny a??ia?aeia cieaeaiiy CIIN a iaio a?oiao, a?eueo cia/ia a a?oi? oai?eo, ye? e?eoaaeenue aiaeai?eeii. I?e a?aenooiueino? a??ia?aeieo a?aei?i a aeaiiio iieacieeo i?ae a?oiaie aei ii/aoeo oa?ai?? a e?ioe? eo?no e?eoaaiiy CIIN aoa a??ia?aeii ieae/ei a a?oi? oai?eo, ye? i?eeiaee aiaeai?ee. AENIIAEE 1. Ee?i?/ia aoaeoeai?noue aiaeai?eea iaeaaoa ? eica?oaia a oa?ai?? oai?eo c AA, yea ioe?ithaaeanue ii nooiaith cieaeaiiy a?oa??aeueiiai oeneo, e?eueeino? iaoe??io?a c ii?iae?caoe??th a?oa??aeueiiai oeneo, e?eueeino? iaoe??io?a c iaiao?aei?noth aeiaeaoeiaiai i?ecia/aiiy aioea?ia?oaiceaieo i?aia?ao?a oa aa?aaeueii-?aeoeiaia?e oeae? a??ia?aeii ia a?ae??ciyeanue. I?e oeueiio eica?oai aeinoia??ii e?aua ia?aiineany iaoe??ioaie ? aeeeeeaa iaioo e?euee?noue iia?/ieo ?aaeoe?e. 2. Ai?no AO-1 o oai?eo c AA i?aeaeuo?oueny, iniaeeai ii i??? i?ia?anoaaiiy caoai?thaaiiy ? ia?inoaiiy iciae o?aaeaiiy i?aai?a-i?oaiae oa i?yii ei?aeth? c ??aiyie nenoie?/iiai ? ae?anoie?/iiai a?oa??aeueiiai oeneo. Ci?ie aoi?eiiiai ianaiaeaea?a ieneaeo acioa – oeAIO iinyoue iae?iaeiee oa?aeoa?, eiiiainaoi?ii i?aeaeuoth/enue ia ?aii?o noaae?yo caoai?thaaiiy aac iciae o?aaeaiiy i?aai?a-i?oaiae ? cieaeoth/enue ii i??? i?ia?anoaaiiy caoai?thaaiiy. 3. Ia ?aii?o noaae?yo AA a?aeiioaiiy aacieiino?eeoi?e/aaciaeeeaoaoi?e (AO-1/oeAIO) ca ?aooiie eiiiainaoi?iiai i?aeaeuaiiy ??aiy oeAIO oo?eio?oueny a ?aieao ii?iaeueieo cia/aiue, oiae? ye i?ia?anoaaiiy AA noi?iaiaeaeo?oueny i?aeaeuaiiyi aeaiiai a?aeiioaiiy. 4. Oa?ai?y aiaeai?eea iaeaaoii ? eica?oaiii a oe?eiio i?eaiaeeoue aei a??ia?aeiiai ciaioaiiy a?aeiioaiiy AO-1/oeAIO, ye ca ?aooiie cieaeaiiy AO-1, oae ? ca ?aooiie i?aeaeuaiiy ai?noo oeAIO. I?e iii??i?e oa aaaee?e AA aieea aiaeai?eea iaeaaoa ia aiaeioae?aeueio aeenooieoe?th ? a?eueo cia/iei ca ?aooiie a?eueoiai i?aeaeuaiiy ai?noo a ieaci? e?ia? aoi?eiiiai ianaiaeaea?a NO – oeAIO ?, a?aeiia?aeii, a?eueoiai cieaeaiiy ni?aa?aeiioaiiy AO-1/oeAIO. 5. Aieea oa?ai?? aeieaoi?aie ?ai?i-aia?ioaiceiiai? nenoaie ia ci?ie e?ioeaai? /anoeie oeoii/eiaiai eiiieaeno AEA a?eueo ae?aaeaiee aeey aiaeai?eea iaeaaoa ? i?iyaey?oueny a ciaioaii? e?eueeino? a?aeaaaeaiue c aeai?an??th naaiaioa ST e ?iaa?n??th coaoey O. Cieaeaiiy ?eceeo iani?eyoeeaiai aeoiaeo ii aeaiei aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai ?iaeaena a??ia?aeii aeua ia oii? oa?ai?? eica?oaiii. 6. Oa?ai?y aeieaoi?aie ?ai?i-aia?ioaiceiiai? nenoaie iiceoeaii aieeaa? ia aaiiaeeiai?/i? iieacieee aaea a ia?o? oeaei? e?eoaaiiy ? i?eaiaeeoue aei ciaioaiiy ia?aae- ? i?neyiaaaioaaeaiiy, ui ioe?ithaaeenue ii ??aiyi EAeI ? CIIN, i?e/iio oa?ai?y aiaeai?eea iaeaaoii a ia?o? oeaei? e?eoaaiiy noi?iaiaeaeo?oueny a?eueo ae?aaeaiei cieaeaiiyi CIIN a ii??aiyii? c oa?ai??th eica?oaiii. I?AEOE*I? ?AEIIAIAeAOe?? 1. E?eoaaiiy AA ?ia?a?oi?aie AIO ia? ia?aaaao a ii??aiyii? c e?eoaaiiyi aioaaii?noaie ?aoeaioi??a aia?ioaiceia II o iaoe??io?a c? ci?iaie e?ioeaai? /anoeie oeoii/eiaiai eiiieaena AEA (aeai?an?y naaiaioa ST, ?iaa?n?y coaoey O), iniaeeai ?oai?/iiai aaiaco oa i?e iaiao?aeiino? oaeaeeiai cieaeaiiy i?neyiaaaioaaeaiiy (ia?eoa?e/iiai iii?o noaeei). 2. E?eoaaiiy AA aioaaii?noaie ?aoeaioi??a aia?ioaiceia II a ii??aiyii? c e?eoaaiiyi ?ia?a?oi?aie AIO ia? ia?aaaao o iaoe??io?a c iani?eyoeeaei i?iaiicii caoai?thaaiiy – aenieei ?eceeii eaoaeueiiai aeoiaeo a?ae na?oeaai-noaeeiieo i?e/ei, yeee iiaea aooe ioe?iaii ca aeiiiiiaith aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai ?iaeaena. 3. Aeiaeaoeiaa ioe?iea aaaeeino? ??cieo noaae?e AA iiaea aooe i?iaaaeaia c o?aooaaiiyi nooiaith aiaeioae?aeueii? aeenooieoe??. I?aeaeuaiiy ai?noo aacieiino?eeoi?a – AO-1 a?aeia?aaea? i?ia?anoaaiiy caoai?thaaiiy oa ia?inoaiiy iciae o?aaeaiiy i?aai?a-i?oaiae, i?yii ei?aethth/e c ??aiyie nenoie?/iiai oa ae?anoie?/iiai a?oa??aeueiiai oeneo. I?aeaeuaiiy eiioeaio?aoe?? ieneaea acioa oa?aeoa?ii aeey ?aii?o noaae?e caoai?thaaiiy aac iciae o?aaeaiiy i?aai?a-i?oaiae, a cieaeaiiy a?aeaoaa?oueny ii i??? i?ia?anoaaiiy caoai?thaaiiy. Aeey ?aii?o noaae?e AA, a?aeiia?aeii, oa?aeoa?ia ii?iaeueia a?aeiioaiiy AO-1/oeAIO, a aeey i?ia?anoth/eo oi?i – i?aeaeuaia. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. I.A. Eiiaeeia. I?anni?iue yooaeo yiaeioaeeia a aaiaca a?oa?eaeueiie aeia?oaicee. // A?a/aaiay i?aeoeea.- 1998.- ?5- N.56-58. 2. I.A.Eiiaeeia. Eeeie/aneay yooaeoeaiinoue oa?aiee ynnaioeeaeueiie aeia?oiiee eiaeaeoi?aie aiaeioaiceii?aa?auathuaai oa?iaioa, aioaaiienoaie ?aoeaioi?ia aiaeioaiceia II. //A?a/aaiay i?aeoeea.- 1999.- ?1- N.71-73. 3. I.A.Eiiaeeia. Aeieaoi?u ?aoeaioi?ia aiaeioaiceia II a oa?aiee a?oa?eaeueiie aeia?oaicee – ?acoeueoaou eeeie/aneeo enneaaeiaaiee.// A?noiee i?iaeai a?ieia?? ? iaaeeoeeie.- 1999.- N6.- N. 12-17. 4. Eiaaeue N.I., Ianeyaaa E.A., Aaeiaie A.I., Ieeineaaneee Ae.E., Iunie/aiei I.A., Eiiaeeia I.A. Eco/aiea yooaeoeaiinoe eicaa?a a ea/aiee aieueiuo aeia?oiie/aneie aieaciueth. //Na. iao/. o?. OAIO "Nia?aiaiiua i?iaeaiu eeeieee aioo?aiieo aieaciae", Oa?ueeia, 1997. - N. 84-87. 5. *a?aaaoia A.A., Ia/a?aiei E.E., Eiiiiaiei E.A., Ai?ciaa A.TH., Eiiaeeia I.A. Aiciiaeiinoe i?eiaiaiey eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa a ea/aiee aieueiuo o?iie/aneie eoaie/aneie aieaciueth na?aeoea. // Na. iao/. o?. OAIO "Nia?aiaiiua i?iaeaiu eeeieee aioo?aiieo aieaciae", Oa?ueeia, 1997. - N.188-193. 6. I.A.Eiiaeeia. ?ieue aioaaiienoia ?aoeaioi?ia aiaeioaiceia II (oeia AO1) a ea/aiee a?oa?eaeueiie aeia?oaicee. //: Na. iao/. o?. OAIO “Iiaua ai?eciiou eeeieee aioo?aiieo aieaciae”, Oa?ueeia, 1998.- N.216. AIIOAOe?ss Eiiae?ia I.A. Aeeoa?aioe?eiaaia i?ecia/aiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai oa?iaioo oa aeieaoi??a ?aoeaioi??a aia?ioaiceia II i?e ??cieo noaae?yo anaioe?aeueii? a?ia?oaic??. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 - ea?ae?ieia?y. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. I?iaaaeai? aeine?aeaeaiiy i?enay/ai? aieeao oa?ai?? aiaeai??eii ? eica?oaiii ia ooieoe?th aiaeioae?y, aeaeo?i- oa aoiea?ae?ia?ao?/i? iieacieee o oai?eo c AA, a oaeiae ee?i?/i?e aoaeoeaiino? ? aacia/iino? oa?ai??, yea i?iaiaeeeanue. I?e ci?anoaai?e ee?i?/i?e aoaeoeaiino?, aacia/i?noue oa?ai?? eica?oaiii aoea aeuith. Ia ?aii?o noaae?yo AA a?aeiioaiiy aacieiino?eeoi?e/aaciaeeeaoaoi?e (AO-1/oeAIO) ca ?aooiie eiiiainaoi?iiai i?aeaeuaiiy ??aiy oeAIO ciaoiaeeoueny a ?aieao ii?iaeueieo cia/aiue, oiae? ye i?ia?anoaaiiy AA noi?iaiaeaeo?oueny i?aeaeuaiiyi aeaiiai ni?aa?aeiioaiiy. Oa?ai?y aiaeai?eea iaeaaoii ? eica?oaiii i?eaiaeeoue aei a??ia?aeiiai ciaioaiiy a?aeiioaiiy AO-1/oeAIO, ye ca ?aooiie cieaeaiiy ??aiy AO-1, oae ? ca ?aooiie i?aeaeuaiiy ai?noo oeAIO. Cieaeaiiy ?eceeo iani?eyoeeaiai aeoiaeo ca aeaieie aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai ?iaeaena a??ia?aeii aeua ia oii? oa?ai?? eica?oaiii. Oa?ai?y aeieaoi?aie ?ai?i-aia?ioaiceiiai? nenoaie iiceoeaii aieeaa? ia aaiiaeeiai?/i? iieacieee aaea a ia?o? oeaei? e?eoaaiiy ? i?eaiaeeoue aei ciaioaiiy ia?aae- ? i?neyiaaaioaaeaiiy, i?e/iio oa?ai?y aiaeai?eeii noi?iaiaeaeo?oueny a?eueo ae?aaeaiei cieaeaiiyi caaaeueiiai ia?eoa?e/iiai iii?o a ii??aiyii? c oa?ai??th eica?oaiii. Eeth/ia? neiaa: a?oa??aeueia a?ia?oaic?y, ?ia?a?oi?e aia?ioaiceiia?aoai?thth/iai oa?iaioa, aioaaii?noe ?aoeaioi??a aia?ioaiceia II, aiaeioae?i-1, ieneae acioa, oeeee?/iee aoaiicei-3”,5”-iiiioinoao. AIIIOAOeEss Eiiaeeia I.A. Aeeooa?aioee?iaaiiia i?eiaiaiea eiaeaeoi?ia aiaeioaiceii?aa?auathuaai oa?iaioa e aeieaoi?ia ?aoeaioi?ia aiaeioaiceia II i?e ?acee/iuo noaaeeyo ynnaioeeaeueiie aeia?oaicee. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 - ea?aeeieiaey. Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. I?iaaaeaiiua enneaaeiaaiey iinayuaiu aeeyieth oa?aiee eiaeaeoi?aie AIO e aeieaoi?aie ?aoeaioi?ia aiaeioaiceia II ia ooieoeeth yiaeioaeey, yeaeo?i- e yoiea?aeeia?aoe/aneea iieacaoaee o aieueiuo n AA, a oaeaea eeeie/aneie yooaeoeaiinoe e aaciianiinoe i?iaiaeeiie oa?aiee. Iieacaii, /oi i?e niiinoaaeiie eeeie/aneie yooaeoeaiinoe, aaciianiinoue oa?aiee eica?oaiii auea auoa. Oae, a a?oiia iaoeeaioia, iieo/aaoeo yiaeai?ee, /a?ac 20 aeiae ea/aiey nenoiee/aneia AAe. nieceeinue n 177,416,8 ii.?o.no. aei 150,18,4 ii.?o.no. (p<0.001), aeeanoiee/aneia AAe – n 105,28,3 ii.?o.no. aei 90,33,2 ii.?o.no. (p<0.001). A a?oiia iaoeeaioia, iieo/aaoeo eica?oai, nenoiee/aneia AAe nieceeinue n 175,715,6 ii.?o.no. aei 149,37,5 ii.?o.no. (p<0.001) e aeeanoiee/aneia AAe – n 106,49,7 ii.?o.no. (p<0.001). Eiee/anoai iiai/iuo yooaeoia a a?oiia iaoeeaioia, iieo/aaoeo yiaeai?ee, ninoaaeei 25,8% (16 iaoeeaioia) i?ioea 10,3% (6 iaoeeaioia) a a?oiia aieueiuo, iieo/aaoeo eica?oai (p<0.05). Auyaeaii, /oi ia ?aiieo noaaeeyo AA niioiioaiea aacieiino?eeoi?u/aaciaeeeaoaoi?u (YO-1/oeAIO) ca n/ao eiiiainaoi?iiai iiauoaiey o?iaiy oeAIO oaea?aeeaaaony a i?aaeaeao ii?iaeueiuo cia/aiee, oiaaea eae i?ia?anne?iaaiea AA nii?iaiaeaeaaony iiauoaieai aeaiiiai niioiioaiey. A eiio?ieueiie a?oiia niioiioaiea YO-1/oeAIO ninoaaeei 0,910,28. O iaoeeaioia n aeeeoaeueiinoueth AA iaiaa 1 aiaea yoi niioiioaiea auei aeinoiaa?ii ieaea - 0,910,28 (p<0.05), ca n/ao iiauoaiey o?iaiy oeAIO. I?e aeeeoaeueiinoe caaieaaaiey io 1 aiaea aei 5 eao niioiioaiea YO-1/oeAIO aeinoiaa?ii iiauoaaony (ca n/ao iiauoaiey o?iaiy YO-1 e nieaeaiey niaea?aeaiey oeAIO) ia oieueei ii n?aaiaieth n a?oiiie iaoeeaioia n aeeeoaeueiinoueth caaieaaaiey aei 1 aiaea (p<0.001), ii e ii n?aaiaieth n eiio?ieueiie a?oiiie e ninoaaeyao 1,010,22. Auyaeaia iieiaeeoaeueiay ei??aeyoeeiiiay caaeneiinoue iaaeaeo niaea?aeaieai YO-1 e o?iaiai nenoiee/aneiai AAe (r=0.72, p<0.001), e oaeay aea (oioy ianeieueei iaiaa au?aaeaiiay) caaeneiinoue iaaeaeo o?iaiyie YO-1 e aeeanoiee/aneei AAe (r=0.61, p<0.02). A oi aea a?aiy ei??aeyoeeiiiue aiaeec, i?iaaaeaiiue a a?oiiao aieueiuo n ?acee/iie aeeeoaeueiinoueth caaieaaaiey, iieacae, /oi a a?oiia iaoeeaioia n aeeeoaeueiinoueth caaieaaaiey aei 1 aiaea o?iaaiue oeAIO i?yii ei??aee?iaae n o?iaiai AAe – nenoiee/aneiai n r=0.54, p<0.05 e aeeanoiee/aneiai – n r=0.68, p<0.01. O iaoeeaioia n aeeeoaeueiinoueth aieaa 5 eao iaaethaeaeanue ia?aoiay ei??aeyoeeiiiay caaeneiinoue iaaeaeo o?iaiyie oeAIO e AAe – aeey nenoiee/aneiai n r=0.49, p<0.05 e aeey aeeanoiee/aneiai n r=0.59, p<0.02. Oa?aiey yiaeai?eea iaeaaoii e eica?oaiii a oeaeii i?eaiaeeo e aeinoiaa?iiio oiaiueoaieth niioiioaiey YO-1/oeAIO, eae ca n/ao nieaeaiey o?iaiy YO-1, oae e ca n/ao iiauoaiey niaea?aeaiey oeAIO. I?e oia?aiiie e oyaeaeie AA aeeyiea yiaeai?eea iaeaaoa ia yiaeioaeeaeueioth aeenooieoeeth yaeyaony aieaa cia/eiui ca n/ao aieueoaai iiauoaiey niaea?aeaiey a ieacia aoi?e/iiai iannaiaeaea?a NO – oeAIO e, niioaaonoaaiii, aieueoaai nieaeaiey niioiioaiey YO-1/oeAIO. Nieaeaiea ?enea iaaeaaii?eyoiiai enoiaea ii aeaiiui yeaeo?iea?aeeia?aoe/aneiai i?iaiinoe/aneiai eiaeaena aeinoiaa?ii auoa ia oiia oa?aiee eica?oaiii. N?aaeiea cia/aiey aeaiiiai eiaeaena a a?oiiao aieueiuo, iieo/aaoeo yiaeai?ee eee eica?oai, aei ia/aea ea/aiey ninoaaeee 18,94,1e 17,84,3 (?acee/ey iaaeinoiaa?iu, p>0.20). Iinea eo?na ea/aiey a a?oiia
iaoeeaioia, iieo/aaoeo yiaeai?ee, iaaethaeaeanue oaiaeaioeey e
nieaeaieth aeaiiiai iieacaoaey ii n?aaiaieth n aeaiiuie aei ea/aiey
(15,45,1), ia aeinoeaay noaoenoe/anee aeinoiaa?iuo ?acee/ee. A oi aea
a?aiy a a?oiia iaoeeaioia, iieo/aaoeo eica?oai, nieaeaiea aeaiiiai
iieacaoaey auei aeinoiaa?iui — 15,94,9 (p<0.05). Oa?aiey aeieaoi?aie ?aiei-aiaeioaiceiiaie nenoaiu ieacuaaao iieiaeeoaeueiia aeeyiea ia aaiiaeeiaie/aneea iieacaoaee oaea a ia?aua iaaeaee ea/aiey e i?eaiaeeo e oiaiueoaieth i?aae- e iinoiaa?ocee, i?e/ai oa?aiey yiaeai?eea iaeaaoii a ia?aua iaaeaee ea/aiey nii?iaiaeaeaaony aieaa au?aaeaiiui nieaeaiei iauaai ia?eoa?e/aneiai nii?ioeaeaiey ninoaeia ii n?aaiaieth n oa?aieae eica?oaiii. Eeth/aaua neiaa: a?oa?eaeueiay aeia?oaicey, eiaeaeoi?u aiaeioaiceii?aa?auathuaai oa?iaioa, oeaio?aeueiay aaiiaeeiaieea, aioaaiienou ?aoeaioi?ia aiaeioaiceia II, yiaeioaeei-1, ieneae acioa, oeeeee/aneee aoaiicei-3”,5”-iiiioinoao. ANNOTATION Lomakina O.V. Differential using of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonist in different stages of essential hypertension. – Manuscript. Thesis on competition of a scientific degree of the candidate of medical science on the speciality 14.01.11 – cardiology. Kharkov state medical university, Kharkov, Ukraine, 1999. The conducted research are devoted to study influence of therapy with enalapril and losartan on endothelial function, ECG and echocardiographic parameters, as well its clinical efficacy and safety in patients with essential hypertension. Were shown that efficacy of these drugs was equivalent, than losartan possess higher safety. In early stage of hypertension vasoconstrictors/vasodilatators (ET-1/cGMP) ratio is near normal because compensation increasing of cGMP level, then progression of arterial hypertension leads to increasing of such ratio. Therapy with enalapril and losartan leads to significant decreasing of ET-1/cGMP ratio as consequence of decreasing of ET-1 level and increasing of cGMP concentration. Decreasing of unfavorable outcome by ECG index is more pronounced with losartan. Renin-angiotensin system blockers have positive influence on hemodynamic parameters already during first weeks of treatment and lead to declining of pre- and afterloud. In this case enalapril more effective in afterloud reduction. Key words: arterial hypertension, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonist, endothelin-1, nitric oxide, cyclic guanosin-3”,5”-monophosphat.

Похожие записи