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Диференційоване призначення інгібіторів ангіотензинперетворюючого ферменту та блокаторів рецепторів ангіотензина II при різних стадіях есенціальної гі

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2

OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

Eiiae?ia Ieueaa Aanee?aia

OAeE 616.12-008.331.1-085.225.2

Aeeoa?aioe?eiaaia i?ecia/aiiy ?ia?a?oi??a aia?ioaiceiia?aoai?thth/iai
oa?iaioo oa aeieaoi??a ?aoeaioi??a aia?ioaiceia II i?e ??cieo noaae?yo
anaioe?aeueii? a?ia?oaic??

14.01.11 – ea?ae?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Eaoiaoc ?aai E?iae?aoiae/, Oa?e?anueeee
aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e aioo??oi?o
oai?ia, EOE oa NI.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Eiaaeueiaa Ieueaa Ieeiea?aia,
Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia ?1;

eaiaeeaeao iaaee/ieo iaoe, aeioeaio Oonoaaeue Ieeiea Oaaei?iae/,
Oa?e?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe, caa?aeoaa/
eaoaae?e ea?ae?ieia?? oa ooieoe?iiaeueii? ae?aaiinoeee.

I?ia?aeia onoaiiaa:

?inoeooo ea?ae?ieia?? ?iai? aeaaeai?ea I.Ae. No?aaeanea AII Oe?a?ie,
a?aeae?e a?ia?oii?/ii? oai?iae.

Caoeno a?aeaoaeaoueny “_14__” aeiaoiy 1999 ?. i _13 – 30__ aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ( 310022,

i. Oa?e?a, i?. Eai?ia, 4.)

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ( 310022, i. Oa?e?a, i?. Eai?ia,
4.)

Aaoi?aoa?ao ?ic?neaiee “ _3_ “ _aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee, e.i.i, aeioeaio. E.?. Ia/a?aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aeniea ?iciianthaeaeai?noue a?oa??aeueii?
a?ia?oaic?? (AA) a Oe?a?i? (ca?aeii aeaieo ai?aeai?ieia?/ieo
aeine?aeaeaiue aiia neeaaea? aei 20% ianaeaiiy), ca?eueoaiiy ia oii?
i?aeaeuaiiai a?oa??aeueiiai oeneo ?eceeo nia?oiino?, aeieeiaiiy
?oai?/ii? oai?iae na?oey (?ON), ?inoeueoo, na?oeaai? iaaeinoaoiino?
(NI), o?ii?/ii? ie?eiai? iaaeinoaoiino?, iia’ycai? c oeei iaaee/i? oa
nioe?aeuei? i?iaeaie, a oaeiae aeiiii?/i? cao?aoe iaoiiaeththoue
iino?eiee ?ioa?an aei i?iaeai iaoiaaiaco oa e?eoaaiiy aeaiiai
caoai?thaaiiy. (?.I.Ni??iiaa, 1998, V.J.Dzau, G. Gibbons, 1991, S.
MacMahon et al., 1997).

A ca’yceo c oni?oaie iieaeoey?ii? a?ieia?? oa aenia?eiaioaeueii?
iaaeeoeeie noaei iiaeeeaei aea/aiiy iaei??? c iaea?eueo oe?eaaeo i?iaeai
a oe?e iaeano? – ?ie? aiaeioae?aeueii? aeenooieoe?? a iaoiaaiac? AA
(P.M. Vanhoutte, 1993, C.J. Ferro, D.J. Webb, 1997).

A ?acoeueoao? aaaaoi/enaeueieo aeine?aeaeaiue aoei anoaiiaeaii, ui
aiaeioae?aeuei? ee?oeie neioacothoue oa aea?eueiththoue a?ieia?/ii
aeoeai? ?a/iaeie, ye? eiio?ieththoue oiion oa ??no aeaaeaiueeii’yciai?
ioneoeaoo?e noaeei. Oe? noanoaioe?? aeeth/athoue iiooaei?
aaciaeeeaoaoi?e oa ?ia?a?oi?e oaeoi??a ?inoo – ieneae acioo (NO),
iao??eo?aoe/iee iaioeae oeio N, i?inoaoeeee?i, iaaeaaii a?aee?eoee
iaioeae aae?aiiiaaeoe?i oa aiaeioae?i-1 (AO-1) – iaeei c naieo
iiooaeieo na?aae a?aeiieo ia nueiaiaeiyoi?e aeaiue aacieiino?eeoi??a
(I.I. Ai?aa/aaa e ae?., 1991, C.B. Treasure, 1993, J.C. Burnett, 1997).

A ee?i?/ieo oiiaao ii?ooaiiy aiaeioae?aeueii? ooieoe?? ? ?ieue a ieo
AO-1 ? nenoaie NO iaea?eueo aea/aii i?e aoa?ineea?ic?. Aeey AA ia
nueiaiaeiyoi?e aeaiue a?aeiii, ui i?aeaeuaiiy a?oa??aeueiiai oeneo (AO)
o oaeeo oai?eo anioe?th?oueny c iia??oaiiyi aiaeioae?e-caeaaeii?
aaci?aeaenaoe??. Aeenooieoe?y aiaeioae?y iiaea aooe aeyaeaia i?e
canoinoaaii? oaeeo aaii?no?a, ye aoeaoeeoie?i aai a?aae?e?i?i, ye?
ae?thoue ia ??ai? ??ciiiai?oieo ?aoeaioi??a oa oeyo?a ia?aaea/?
i?aeee?oeiiiai neaiaea (A.Lerman, 1995).

E??i oeueiai, AA oaeiae oa?aeoa?eco?oueny no?oeoo?ieie ii?ooaiiyie
noaeei, ye? i?eaiaeyoue aei i?aeaeuaiiy ni?aa?aeiioaiiy oiaueia
no?iee/aioo??oi?e ae?aiao? noaeeie. Oe? no?oeoo?i? ii?ooaiiy a??ia?aeii
yaeythoueny e?eoe/ieie aeey i?aeo?eiee oa i?ia?anoaaiiy a?ia?oaic??,
iacaeaaeii a?ae ?? ao?ieia??. A oeueiio ca’yceo aaaeeeai i?aee?aneeoe,
ui ?ai?i-aia?ioaiceiiaa nenoaia a?a? eeth/iao ?ieue a iiaeoeyoe??
noaeeiii? no?oeoo?e i?e a?ia?oaic?? (M. Caulfield et al., 1994, J.
Beige, 1997).

I?aia?aoe, ye? canoiniaothoue aeey e?eoaaiiy AA, iiaeii? ia o?eueee
aoaeoeaii cieaeoaaoe ??aaiue AO, aea e iiceoeaii aieeaaoe ia i?ioeane
?aiiaeaethaaiiy noaeei oa na?oey. Oae, ?ia?a?oi?e
aia?ioaiceiia?aoai?thth/iai oa?iaioo (AIO), ye aoei iieacaii a
??ciiiai?oieo aeine?aeaeaiiyo, ia o?eueee aoaeoeaii cieaeothoue ??aaiue
AO, aea e ca ?aooiie aeieaaee ooai?aiiy aia?ioaiceio II oa i?aeaeuaiiy
ai?noo a?aaeee?i?io (ui i?eaiaeeoue aei aea?eueiaiiy ieneaeo acioo oa
i?inoaoeeee?io) aeyaeythoue ni?eyoeea? aoaeoe ia ooieoe?th aiaeioae?y
(K.B. Brosnihan et al., 1996, D.J. Campbell et al., 1996).

Ia a?aei?io a?ae ?ia?a?oi??a AIO aioaaii?noe ?aoeaioi??a aia?ioaiceia II
caaacia/othoue niaoeeo?/io aeieaaeo ?aoeaioi??a aia?ioaiceio II ia?oiai
oeio ? ia i?aeaeuothoue ??aaiue a?aaeee?i?io (K. Tsunoda et al., 1993,
C.I. Johnston et al., 1997). Iaeiae, aei oaia??oiueiai /ano ia aea/aii
ii??aiyiee aieea ?ia?a?oi??a AIO oa aeieaoi??a ?aoeaioi??a aia?ioaiceia
II ia iieacieee, ye? oa?aeoa?ecothoue ooieoe?th aiaeioae?th o oai?eo c
AA ? ia ?ic?iaeaii aeeoa?aioe?eiaai? noaie i?ecia/aiiy oeeo i?aia?ao?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iaoa??aee
aeena?oaoe?? aeieeaathoue c ieaiiaeo iaoeiai-aeine?aeieo ?ia?o
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. Aeena?oaoe?eia
?iaioa ? neeaaeiaith /anoeiith iaoeiai-aeine?aeieo ?ia?o eaoaae?e
“Iaoieia?y na?oeaai-noaeeiii? nenoaie” ? Aea?ae. ?a?no?aoe??
01950023462.

Iaoa aeine?aeaeaiiy. ?ic?iaea noai aeeoa?aoe?eiaaiiai i?ecia/aiiy
?ia?a?oi?a AIO aiaeai?eea iaeaaoa oa aioaaii?noa ?aoeaioi??a
aia?ioaiceia II eica?oaia ia iniia? aea/aiiy ?o aieeao ia
aeaeo?iea?ae?ia?ao?/i? oa aaiiaeeiai?/i? ia?aiao?e ? iieacieee, ye?
oa?aeoa?ecothoue ooieoe?th aiaeioae?y o oai?eo c ??cieie oi?iaie AA aeey
i?aeaeuaiiy aoaeoeaiino? oa?ai?? oa iie?auaiiy i?iaiico caoai?thaaiiy.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe ee?i?/io aoaeoeai?noue oa aacia/i?noue oa?ai?? aiaeai?eea
iaeaaoii (?ai?oae) ? eica?oaiii (eicaa?) o oai?eo c ??cieie ee?i?/ieie
oi?iaie AA.

2. Aecia/eoe ??ai? AO-1 oa aoi?eiiiai ianaiaeaea?a NO – oeAIO oa
ioe?ieoe ni?aa?aeiioaiiy aacieiino?eeoi?ieo (AO-1) ? aaciaeeeaoaoi?ieo
(oeAIO) oaeoi??a i?e ??cieo ee?i?/ieo oi?iao AA.

3. Anoaiiaeoe aieea ia aiaeioae?aeueio aeenooieoe?th ?i?aa?oi?a AIO
aiaeai?eea iaeaaoa oa aioaaii?noa ?aoeaioi??a aia?ioaiceia II eica?oaia
ia i?aenoaa? aeeiai?ee ??ai?a AO-1 ? oeAIO i?ae aieeaii oa?ai?? aeaieie
i?aia?aoaie o oai?eo c AA.

4. Aeine?aeeoe aeeiai?eo aeaeo?iea?ae?ia?ao?/ieo iieaciee?a ?
aaiiaeeiai?/ieo ia?aiao??a o oai?eo c AA i?ae aieeaii oa?ai?? aiaeai?eea
iaeaaoii oa eica?oaiii.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aea/aia ii??aiyeueia ee?i?/ia
aoaeoeai?noue oa aacia/i?noue oa?ai?? ?i?a?a?oi?a AIO aiaeai?eea iaeaaoa
oa aeieaoi?a ?aoeaioi??a aia?ioaiceia II eica?oaia o oai?eo c ??cieie
ee?i?/ieie oi?iaie AA. Anoaiiaeaia caeaaei?noue ee?i?/ieo i?iya?a oa
??ai?a AO a?ae nooiaith aiaeioae?aeueii? aeenooieoe??, yeo ioe?ithaaee
ii ??aiyi AO-1 ? oeAIO, oa iiaeeea?noue iie?auaiiy ooieoe?? aiaeioae?th
i?ae aieeaii oa?ai?? i?aia?aoaie, ui aea/aeenue. Iieacaii iiceoeaiee
aieea aeieaoi??a ?ai?i-aia?ioaiceiiai? nenoaie ia aaiiaeeiai?/i? oa
aeaeo?iea?ae?ia?ao?/i? iieacieee, ui i?iyaeyany aeey aiaeai?eea iaeaaoa
a a?eueo?e /anoio? ii?iae?caoe?? e?ioeaai? /anoeie oeoii/eiaiai
eiiieaeno AEA ? a a?eueo cia/ouiio cieaeaii? caaaeueiiai ia?eoa?e/iiai
iii?o noaeei, a aeey eica?oaia – a a?eueo cia/eiiio iie?auaii?
aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai ?iaeaena. Aeyaeaii, ui ??ai? AO
oa noaae?y AA a cia/i?e i??? aecia/athoueny ai?noii AO-1 ? oeAIO, a
oaeiae ?o ni?aa?aeiioaiiyi – i?aeaeuaiiy eiioeaio?aoe?? aacieiino?eeoi?a
AO-1 oa aeniaaeaiiy iiaeeeaino? eiiiainaoi?iiai neioaco aaciaeeeaoaoi?a
NO aecia/a? nooi?iue aiaeioae?aeueii? aeenooieoe?? ?, ye iane?aeie,
??ai? AO oa noaae?th AA. Oa?ai?y aeieaoi?aie ?ai?i-aia?ioaiceiiai?
nenoaie ni?ey? iie?auaiith ooieoe?? aiaeioae?y.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iieacaia aeniea ee?i?/ia
aoaeoeai?noue oa?ai?? AA aeieaoi?aie ?ai?i-aia?ioaiceiiai? nenoaie i?e
a?eueo?e aacia/iino? eica?oaia a ii??aiyii? c aiaeai?eea iaeaaoii.
Aeyaeaii, ui ni?aa?aeiioaiiy aacieiino?eeoi??a oa aaciaeeeaoaoi??a
(AO-1/oeAIO) ia ?aii?o noaae?yo caoai?thaaiiy ciaoiaeeoueny a ?aieao
ii?iaeueieo cia/aiue, oiae? ye i?ia?anoaaiiy AA noi?iaiaeaeo?oueny
i?aeaeuaiiyi aeaiiai ni?aa?aeiioaiiy. Oa?ai?y aeieaoi?aie
?ai?i-aia?ioaiceiiai? nenoaie i?eaiaeeoue aei iie?auaiiy aeaiiai
ni?aa?aeiioaiiy, i?e/iio i?e iii??i?e oa aaaee?e oi?i? AA aieea
aiaeai?eea iaeaaoa ia aiaeioae?aeueio aeenooieoe?th ? a?eueo cia/ouei ca
?aooiie a?eueoiai i?aeaeuaiiy ai?noo a ieaci? aoi?eiiiai ianaiaeaea?a
ieneaea acioa – oeAIO ?, a?aeiia?aeii, a?eueoiai cieaeaiiy
ni?aa?aeiioaiiy AO-1/oeAIO.

Aeyaeaii, ui canoinoaaiiy aiaeai?eea iaeaaoa a ii??aiyii? c eica?oaiii o
oai?eo c AA a?eueo iieacaii o iaoe??io?a c? ci?iaie e?ioeaai? /anoeie
oeoii/eiaiai eiiieaeno AEA, iniaeeai ?oai?/iiai iioiaeaeaiiy, ? i?e
iaiao?aeiino? oaeaeeiai cieaeaiiy caaaeueiiai ia?eoa?e/iiai iii?o
noaeei, oiae? ye aeei?enoaiiy eica?oaia ia? ia?aaaae o oai?eo c aenieei
?eceeii iani?eyoeeaiai ia?aa?ao caoai?thaaiiy, yeee iiaea aooe
?ic?aoiaaii ca aeiiiiiaith aeaeo?iea?ae?ia?ao?/iiai i?iaiinoe/iiai
?iaeaena.

Aeai?, io?eiai? i?e aeeiiaii? ?iaioe, aeei?enoiaothoueny a
iaaeaaia?/iiio i?ioean? ia eaoaae?? aioo??oi?o oai?ia, EOE oa NI
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. ?acoeueoaoe
aeine?aeaeaiiy ai?iaaaeaeaii a i?aeoeeo ?iaioe ?inoeoooo oa?ai?? AII
Oe?a?ie, aei?iaeii? ee?i?/ii? e?ea?i? ?2 ICAe, i?nueei? ee?i?/ii?
e?ea?i? ?27 i. Oa?eiaa, i?nueei? ee?i?/ii? e?ea?i? ?28 i. Oa?eiaa,
Oa?e?anueei? iaeanii? nooaeaionueei? e?ea?i?, i?nueei? ee?i?/ii? e?ea?i?
?11 i. Oa?eiaa.

Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai iniaenoi i?iaiae?ciaaia iaoeiaa
e?oa?aoo?a ii i?iaeai?, ui aea/aeanue, i?iaaaeaii
ee?i?ei-?ino?oiaioaeueia ianoaaeaiiy, a oiio /ene? oeueo?acaoeiaa
ianoaaeaiiy oa ia?iaea aeaieo aeaeo?iea?ae?ia?ao?? c aeei?enoaiiyi
i?ea?iaeueii? iaoiaeeee. ?ic?iaeaia noaia aeeoa?aioe?eiaaiiai
i?ecia/aiiy aiaeai?eea iaeaaoa ? eica?oaia a caeaaeiino? a?ae oi?ie oa
nooiaith a?oa??aeueii? a?ia?oaic??. Aaoi?ii i?iaaaeaia noaoenoe/ia
ia?iaea ? aiae?c io?eiaieo ?acoeueoao?a c aeei?enoaiiyi no/anieo
iaoaiaoe/ieo iaoiae?a oa eiii’thoa?ii? oaoi?ee. Caeiaoaa/ai naiino?eii
iaienai? an? ?icae?ee ?iaioe, noi?ioeueiaaii aeniiaee oa i?aeoe/i?
?aeiiaiaeaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aeaeeny oa iaaiai?thaaeeny ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo
iieiaeeo a/aieo (Oa?e?a, 1996, 1997), can?aeaiiyo Oa?e?anueeiai
iaoeiai-iaaee/iiai oiaa?enoaa (Oa?e?a, 1998), iaoeiai-i?aeoe/i?e
eiioa?aioe??, i?enay/ai?e i?iaeaiai aei?iaeiuei? iaaeeoeeie (Oa?e?a,
1997) oa iaoeiai-i?aeoe/i?e eiioa?aioe?? “Iia? ai?eciioe ee?i?ee
aioo??oi?o caoai?thaaiue” (Oa?e?a, 1998).

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 6 ?ia?o (3 noaoo? o
iaoeiaeo aeo?iaeao oa 3 noaoo? a ca??ieeao iaoeiaeo i?aoeue).

No?oeoo?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia 160
noi??ieao ae?oeiaaiiai oaenoo, ?ethno?iaai? 10 iaethieaie oa 11
oaaeeoeyie ? neeaaeathoueny c? anooio, iaeyaeo e?oa?aoo?e, 4 ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e. Nienie aeei?enoaii? e?oa?aoo?e i?noeoue 205 aeaea?ae, c
yeeo 46 a?o/eciyieo oa 159 ca?oa?aeieo.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy

A ianoaaeaiiy aoei aeeth/aii 120 oai?eo c anaioe?aeueiith
a?oa??aeueiith a?ia?oaic??th, ye? ciaoiaeeeenue ia noaoe?iia?iiio
e?eoaaii? a ea?ae?ieia?/iiio a?aeae?eaii? i?nueei? ee?i?/ii? e?ea?i? ?27
i.Oa?eiaa a ia??iae c 1996 ii 1998 ?iee.

Aeei?enoiaoaaee eeaneo?eaoe?th ??ai?a AO o aei?ineeo ? noaae?e AA ii
nooiai? iioeiaeaeaiiy i?aai?a-i?oaiae, cai?iiiiiaai?e AIIC oa
i?aeia?iaeiei oiaa?enoaii ii aea/aiith a?ia?oaic??.

Oai?eo ianoaaeoaaee i?e iinooieaii? (aei i?ecia/aiiy a?iioaiceaii?
oa?ai??) oa ia 20 aeaiue e?eoaaiiy. I?iaiaeeeinue ?ooeiia eaai?aoi?ia
ianoaaeaiiy, a oiio /ene? aecia/aiiy ai?noo aeaeo?ie?o?a e?ia? oa
neai?ioeiaiai e?aao?i?io. Aecia/aiiy ai?noo eae?y ? iao??y i?iaiaeeee a
ieaci? e?ia? (aac iayaiino? iciae aaiie?co) iaoiaeii iieoi’yii?
oioiiao??? c iiaoaeiaith eae?a?iai/ieo e?eaeo. E?aaoei?i ne?iaaoee
aecia/aee oi?o?eiaaiei iaoiaeii eieuei?iai? ?aaeoe?? ssnna ca
aeiiiiiaith iaai??a ?aaeoea?a.

?a?no?aoe?th AEA niieith i?iaiaeeee a 12 noaiaea?oieo a?aeaaaeaiiyo c
aeei?enoaiiyi i?e iaiao?aeiino? aeiaeaoeiaeo a?aeaaaeaiue.

Aeine?aeaeaiiy nei?ioeeai? caeaoiino? i?iea?aea ? ia?aiao??a
aaiiaeeiai?ee i?iaiaeeeinue iaoiaeii oeueo?acaoeiai? aoiea?ae?ia?ao?? ca
aeiiiiiaith aia?aoa OE-628 (Oe?a?ia) a I- oa A-?aaeeiao. ?ic?aoiaoaaee
iaea?eueo iieacia? aaiiaeeiai?/i? ia?aiao?e: e?ioeaai-nenoie?/iee ia’?i
(ENI), e?ioeaai-ae?anoie?/iee ia’?i (EAeI) ? o?aeoe?th aeeeaeo (OA)
e?aiai oeoii/ea (EO).

Iieacieee, ui oa?aeoa?ecothoue ooieoe?th aiaeioae?y, aecia/aee a ieaci?
e?ia? ?aae?i?ioiieia?/iei (AO-1) oa ?ioiioa?iaioiei (oeAIO) iaoiaeii ca
aeiiiiiaith a?aeiia?aeieo iaai??a. An? ?aaeoeae aeei?enoiaoaaeenue
ca?aeii ?ino?oeoe?? aeey i?iaaaeaiiy aiae?c?a.

Noaoenoe/ia ia?iaea aeaieo i?iaiaeeeanue ca?aeii i?aaee ia?iaee
iaaee/ii-a?ieia?/ii? ?ioi?iaoe?? ca aeiiiiiaith noaoenoe/ii? i?ia?aie
STATISTICA FOR WINDOWS (StatSoft, NOA). An? io?eiai? aeai? iiaeaii o
aeaeyae? na?aaeiueiai a?eoiaoe/iiai (I) eiai noaiaea?oia aeaa?aoe?y
(SD).

?acoeueoaoe aeanieo aeine?aeaeaiue

Na?aae ianoaaeaieo 120 oai?eo aoei 68 /ieia?e?a (57%) oa 52 ae?iee
(43%), na?aaei?e a?e ianoaaeaieo iaoe??io?a neeaa 51,26,1 ?iee;
na?aaeiy o?eaae?noue caoai?thaaiiy – 6,12,3 ?iee.

A caeaaeiino? a?ae ??ai?a AO i?e iinooieaii? aei noaoe?iia?o iaoe??ioe
?iciiae?eyeenue ianooiiei /eiii: i’yea AA aoea aeyaeaia o 71 iaoe??ioa
(59,2%), i?e oeueiio na?aaei? oeeo?e AO neeaee: nenoie?/iee AO 162,414,7
ii.?o.no., ae?anoie?/iee – 100,35,3 ii.?o.no.; iii??ia ? aaaeea AA
niinoa??aaeanue o 49 (40,8%) iaoe??io?a c ianooiieie na?aaei?ie oeeo?aie
AO: nenoie?/iee – 188,516,1 ii.?o.no., ae?anoie?/iee – 109,28,3
ii.?o.no.

O?eueee 14 iaoe??io?a (11,7%) iaee I noaae?th caoai?thaaiiy. O inoaii?o
a?aei?/aeenue o? aai ?io? iciaee o?aaeaiiy i?aai?a-i?oaiae ??ciiai
nooiaith ae?aaeaiino?, a?aeiia?aeii o 61 (50,8%) iaoe??ioa aoea
anoaiiaeaia II-aa oa o 45 (37,5%) iaoe??io?a – III-oy noaae?y
caoai?thaaiiy.

Oneeaaeaio niaaeeia?noue c aieo iaio aaouee?a aaeaeiny aeyaeoe o 18
(15%) iaoe??io?a, c aieo ?iaee/?a ae?oaiai nooiaiy nii??aeiaiino? – o 9
(7,5%) iaoe??io?a. Iaee??iiy ??ciiai nooiaiy aeyaeyeinue o 70,6%
/ieia?e?a (48 iaoe??io?a) oa o 63,5% ae?iie (33 iaoe??ioee). Oeoe?iaee
ae?aaao II oeio niinoa??aaany o 11 (9,2%) iaoe??io?a. Iaeeee a
oaia??oi?e /an 34 (28,3%) iaoe??ioa, 9 (7,5%) aoee iae?yie a ieioeiio.

I?e iinooieaii? a noaoe?iia? iaoe??ioe aeiaaeeiaei /eiii aoee ?icae?eai?
ia 2 a?oie: iaoe??ioai 1-? a?oie, a yeo aa?eoee 62 oai?eo, i?ecia/aee
aiaeai?eea iaeaao (?ai?oae) a ii/aoeia?e aeic? 10 ia ia aeiao, a oai?ei
2-? a?oie, a yeo aa?eoee 58 iaoe??io?a – eica?oai (Eicaa?) a ii/aoeia?e
aeic? 50 ia ia aeiao. A?oie aoee ci?anoaai? ii iniiaiei
ee?i?ei-aeaiia?ao?/iei iieacieeai. ??ai? AO a a?oi? 1 neeaee:
nenoie?/iee 177,416,8 ii.?o.no., ae?anoie?/iee – 105,28,3 ii.?o.no.; a
a?oi? 2 – nenoie?/iee – 175,715,6 ii.?o.no., ae?anoie?/iee – 106,49,7
ii.?o.no.

Ee?i?/ia aoaeoeai?noue oa aacia/i?noue oa?ai??, ui i?iaiaeeeanue,
ioe?ithaaeanue ia 5, 10, 15 oa 20 aeaiue ia?aaoaaiiy a noaoe?iia??,
aeai? i?aaenoaaeaii a oaaeeoe? 1.

?acoeueoaoe, i?aaenoaaeai? a oaaeeoe?, na?ae/aoue i?i aenieo
aoaeoeai?noue e?eoaaiiy a iaio a?oiao oai?eo. I?e oeueiio i? ii iaeiiio
c iieaciee?a, ye? aeei?enoiaoaaeenue aeey ioe?iee ee?i?/ii?
aoaeoeaiino?, ia aoei iaea?aeaii a??ia?aeieo a?aei?iiinoae i?ae a?oiaie.
A oie aea /an aacia/i?noue oa?ai?? a?ae??ciyeanue. O iaoe??io?a, ye?
io?eioaaee eica?oai, ia a?aei?io a?ae iaoe??io?a, ye? io?eioaaee
aiaeai?eea iaeaao, ia aoei a?aei?/aii eaoeth, ?icaeoeo a?ia?eae?ai??,
cia/eii? a?iioaic?? oa aia?iiaa?ioe/ieo iaa?ye?a.

Iaeiae, aiai?y/e i?i iia?/i? aoaeoe, ye? ?icaeaaeenue ia oii? i?eeiio
aiaeai?eea iaeaaoa, iio??aii i?aee?aneeoe, ui a?aei?/aia a?ia?eae?ai?y
ia aoea ee?i?/ii cia/eiith, oae? neiioiie, ye iia??oaiiy niaeo aai
cieaeaiiy aiaoeoo ia iio?aaoaaee a?aei?ie i?aia?aoa, a?iioaic?y o an?o
aeiaaeeao aoea “a?iioaic??th ia?oi? aeice”.

Iia?/i? aoaeoe, ye? iio?aaoaaee a?aei?ie i?aia?aoa, ?icaeeenue o 5
(8,1%) iaoe??io?a a a?oi? 1 oa o 1 (1,7%) iaoe??ioa a a?oi? 2,
a?aei?iiino? iaa??ia?aei?, p0.20). O iaoe??io?a c o?eaae?noth AA a?ae 1 ?ieo aei 5 ?ie?a (n=38)
ai?no AO-1 aoa 7,92,4 ia/ie, ui aoei aeinoia??ii aeua, /ei a eiio?ie?
(p0.20).

Aiae?c i?aea?oi iieacaa, ui i?e a?aenooiino? aeinoia??ieo a?aei?i i?ae
eiio?ieueiith a?oiith oa a?oiith oai?eo c AA a oe?eiio o iaoe??io?a c
o?eaae?noth caoai?thaaiiy aei 1 ?ieo (n=11) ??aaiue oeAIO a??ia?aeii
i?aeaeuoaaany – 9,42,7 iiieue/e, p0.20). O oai?eo c II
(n=34) noaae??th AA (aeyaeythoueny iciaee o?aaeaiiy i?aai?a-i?oaiae) –
8,62,5 ia/ie, ui aoei a??ia?aeii aeua, /ei a eiio?ie? (p0.20), oiae? ye i?e II
noaae?? caoai?thaaiiy ??aaiue oeAIO cia/eii cieaeoaaany – aei 6,01,9
iiieue/e – ia o?eueee a ii??aiyii? c a?oiith iaoe??io?a c I-th noaae??th
caoai?thaaiiy (p0.20).

A?aeiioaiiy AO-1/oeAIO i?e I-e noaae?? oai?iae neeaei 0,880,19, ui ia
a?ae??ciyeinue a??ia?aeii a?ae eiio?ieueii? a?oie. I?e II-e noaae?? oea
a?aeiioaiiy aeinoia??ii c?inoa? aei 1,390,39, ye a ii??aiyii? c
eiio?ieueiith a?oiith (p0.20). Eiioeaio?aoe?y AO-1 a ieaci? e?ia? iaoe??io?a c
iii??iith oa aaaeeith AA (n=30) neeaea 8,43,6 ia/ie. Oe? cia/aiiy aoee
a??ia?aeii aeueie ia o?eueee a ii??aiyii? c a?oiith eiio?ieth (p0.20). I?ney eo?no e?eoaaiiy a a?oi? iaoe??io?a, ye?
io?eioaaee aiaeai?ee, niinoa??aaeanue oaiaeaioe?y aei cieaeaiiy aeaiiai
iieacieea a ii??aiyii? c aeaieie aei e?eoaaiiy aei 15,45,1, yea ia
aeinyaea noaoenoe/ii aeinoia??ieo a?aei?i. A oie aea /an a a?oi?
iaoe??io?a, ye? io?eioaaee eica?oai, cieaeaiiy aeaiiai iieacieea aoei
a??ia?aeiei – 15,94,9 (p0.20). Iinea eo?na ea/aiey a a?oiia
iaoeeaioia, iieo/aaoeo yiaeai?ee, iaaethaeaeanue oaiaeaioeey e
nieaeaieth aeaiiiai iieacaoaey ii n?aaiaieth n aeaiiuie aei ea/aiey
(15,45,1), ia aeinoeaay noaoenoe/anee aeinoiaa?iuo ?acee/ee. A oi aea
a?aiy a a?oiia iaoeeaioia, iieo/aaoeo eica?oai, nieaeaiea aeaiiiai
iieacaoaey auei aeinoiaa?iui – 15,94,9 (p

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