?INOEOOO IAAe?AO???, AEOOA?NOAA OA A?IAEIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

IEOE?IA EA?ENA AIEIAeEIE??AIA

OAeE 618.14-002-036-08-084

Ae?AAIINOEEA, EE?I?EA OA E?EOAAIIss AAI?OAEUeIIAI AIAeIIAO??ICO,
II?AeIAIIAI

C O?II?*IEIE CAIAEUeIEIE I?IOeANAIE

14.01.01- aeooa?noai ? a?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie

IAOEIA? EA??AIEEE:

aeieoi? iaaee/ieo iaoe, i?ioani?

EAUEINUeEEE IAO?I OAAe?EIAE*

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie,

caa?aeoaa/ eaoaae?e aeooa?noaa oa a?iaeieia??

aeieoi? iaaee/ieo iaoe

OeEIEOI AIAOIE?E A?EAI?IAE*

?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie,

ea??aiee eaai?aoi?ii-aeine?aeiiai a?aeae?eo

IO?Oe?EI? IIIIAIOE:

aeieoi? iaaee/ieo iaoe, i?ioani?

AANAAe?I A?EOI? IEEIEAEIAE*

Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie,

caa?aeoaa/ eaoaae?e aeooa?noaa oa a?iaeieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

EIOAIAAE* ?AAAI?ss A?EOI??AIA

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I. E. Ooieea

IIC Oe?a?ie,

caa?aeoaa/ea eaoaae?e aeooa?noaa oa a?iaeieia??

I?IA?AeIA ONOAIIAA:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i I. I. Aiaiiieueoey IIC Oe?a?ie

(i. Ee?a), eaoaae?a aeooa?noaa oa a?iaeieia??.

Caoeno aeena?oaoe?? a?aeaoaeaoueny » 26 «___n?/iy___1999 ?. i 13
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.533.01 ii
caoenoo aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaoe ca
niaoe?aeueiinoyie «Iaae?ao??y, Aeooa?noai ? a?iaeieia?y» i?e ?inoeooo?
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i. Ee?a, aoe.
Iaio?euenueeiai, 8).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (252050, i. Ee?a, aoe.
Iaio?euenueeiai, 8).

Aaoi?aoa?ao ?ic?neaiee «30» aa?aniy 1998 ?ieo

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efefefefefefefefefefefefefefefefefefefefffffffffffffffffffffffefefefefef
efefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefef
efefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefef
efefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefef
efefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefefef
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efefefefefefefefefefefefefefefefefefefefefefe000400000007010100030000000
000

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee Eaaoi?ia
E. A.

11

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aaiioaeueiee aiaeiiao?iic, ii?aeiaiee c o?ii?/ieie
caiaeueieie i?ioeanaie — iaeia c iaea?eueo aaaeeeaeo no/anieo
iaaeeei-nioe?aeueieo i?iaeai. C iaeiiai aieo, iaeaeaa caoai?thaaiiy
iin?aeathoue aaaeo/? i?noey (caiaeuei? caoai?thaaiiy — ae?oaa, a
aaiioaeueiee aiaeiiao?iic — o?ao?) a no?oeoo?? a?iaeieia?/ii?
caoai?thaaiino? (ss.I.Nieueneee e niaao., 1990; I.O.Eaueineee, 1991;
I.E. Aaeen, 1992; E.E.Eaaithoa e niaao., 1992; A.ss.Aieioa e niaao.,
1995; A.I.Caii?iaeai, I.?.Oeaaaeueneee, 1996; A.I.No?eaeaeia,
A.E.Aeaauaeia, 1996; A.I. Aanaae?i, 1997; ?. A. Eioaiaa?/, 1997; P.Y.
Lu, S.J.Ory, 1995). C ?ioiai aieo, aeiaaio?eaaeee, no?eeee ia?aa?a
caoai?thaaiiy, /ano? ?aoeeaeeae, ae?aaeaiee aieueiaee neiae?ii,
ii?ooaiiy iaino?oaeueii? ooieoe??, aaeeea /anoioa iaie?aeiino?, aenieee
a?aenioie iaiaaeaiiy i?aoeacaeaoiino? oa iiaaeiaeecaoeiy ae?iie
aecia/athoue iaaee/io i nioe?aeueio cia/ei?noue oe??? i?iaeaie (A.I.
Aaneaeia, 1990; E.A. Aeoeaiei , 1991; E.A. Aaeaiyi, 1992; I.N. Aeaeeaei,
1993; I.I.Eocueieia, 1993; H.D.Barlow, 1996; I.A.Brosens, 1996).

?acii c oei, aei oeueiai /ano ia ?nio? ?aeeieo i?aeoiae?a aei
ae?aaiinoeee aaiioaeueiiai aiaeiiao?iico naia a ii?aeiaii? c o?ii?/ieie
caiaeueieie i?ioeanaie, caeeoathoueny aeeneon?eieie oa iaeaea
iaae??oaieie ieoaiiy iaoiaaiaco, ui noai?th? a?aeii? o?oaeiiu? i?e
aeai?? iaoiae?a i cania?a oa?ai?? (I.O.Eaueineee, 1991; Di Gesu A. et
al., 1989) .

Iaeii/anii a?aecia/a?oueny a?aenooi?noue ?aoe?iiaeueieo, iaoeiai
iaa?oioiaaieo ?aeiiaiaeaoe?e uiaei oaeoeee eiina?aaoeaiiai aai
o??o?a?/iiai e?eoaaiiy aaiioaeueiiai aiaeiiao?iico a ii?aeiaii? c
o?ii?/ieie caiaeueieie i?ioeanaie.

sse iaaee/ia i?iaeaia, aaiioaeueiee aiaeiiao?iic iin?aea? iniaeeaa
i?noea, ine?eueee i?e iueiio ii?ooo?oueny ye nenoaiiee, oae i i?noeaaee
?ioi?oao. sseui a inoaii? ?iee aniaeoe aea/aiiy caaaeueiiai ?ioi?oaoo
aeaaeae? oe?oa aena?oeththoueny a e?oa?aoo??, oi i?noeaaee ?ioi?oao oa
noai i?e?iaeiiai a?ioeaiico i?oae o iaoe??ioie i?e aaiioaeueiiio
aiaeiiao?iici ?ic?iaeaii iaaeinoaoiuei. Iiaeia ia?ae?/eoe eeoa ie?ai?
i?aoe? a oe?e aaeoc? (N.A.Ia?/oe, 1992; I.I. Eocueieia, 1993; D.Vinatier
et al. 1992).

I?eaa?oa? aei naaa oaaao iayai?noue /anoeo caiaeueieo i?ioean?a o
iaoe??ioie c aaiioaeueiei aiaeiiao?iicii i iaoyaeai?noue iaeiiai ?ioei,
ui noai?th? oiiae aeey ?ioiieia?/ii? aeacaaeaioaoei? oa ?icaeoeo
eaiaeeaeico. C oe??? oi/ee ci?o caoai?thaaiiy i?aeoe/ii ia aea/aeiny.

Aeuaiaaaaeaia aecia/a? iaiao?aei?noue iiaeaeueoiai ??ciia?/iiai
iiaeeaeaiiai aea/aiiy aaiioaeueiiai aiaeiiao?iico a ii?aeiaii? c
o?ii?/ieie caiaeueieie i?ioeanaie oa oaeineiiaeaiiy iaoiae?a eiai
ae?aaiinoeee oa e?eoaaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oey ?iaioa ?
o?aaiaioii iaoeiai-i?aeoe/ii? i?ia?aie eaoaae?e aeooa?noaa ? a?iaeieia??
e?eoaaeueiiai oaeoeueoaoo Eoaainueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo (? aea?ae. ?a?no?aoe?? 01910027181).

Iaoa ?iaioe:

Iaoeiai iaa?oiooaaoe ? ?ic?iaeoe ee?i?ei-eaai?aoi?i? iaoiaee
ae?aaiinoeee oa e?eoaaiiy aaiioaeueiiai aiaeiiao?iico, ii?aeiaiiai c
o?ii?/ieie caiaeueieie i?ioeanaie ia i?aenoaa? ii??aiyeueiiai aea/aiiy
ai?iiiaeueiiai aiiainoaco, i?noeaaiai ?ioi?oaoo, aaa?iaeueiiai
a?ioeaiico ? ai?iaaaeeoe ?o a e?eoaaeueio i?aeoeeo.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe iniaeeaino? ee?i?/iiai ia?aa?ao aaiioaeueiiai aiaeiiao?iico,
ii?aeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie.

2. Aecia/eoe oa?aeoa? ai?iiiaeueiiai aaeaino (ca eiioeaio?aoe??th
i?ieaeoeio, ano?aae?ieo, i?iaanoa?iio, oanoinoa?iio oa ei?oecieo a
ne?iaaooe? e?ia?) o ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c
o?ii?/ieie caiaeueieie i?ioeanaie.

3. Ioa?aeoa?ecoaaoe noai i?noeaaiai ?ioi?oaoo ca aeaieie nae?aoe?? JgA,
SJgA, JgG, JgM a oea?a?eaeueiiio neec? o ae?iie c aai?oaeueiei
aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie.

4. Aea/eoe oa?aeoa? a?eaeiaiai ian?iai?iiy noaoaaeo i?aai?a i?e
aai?oaeueiiio aiaeiiao??ic?, ii?aeiaiiio c o?ii?/ieie caiaeueieie
i?ioeanaie.

5. Aeine?aeeoe noai naenoaeueii? ooieoe?? iiae?oaei?o ia?, ae?iea a yeeo
no?aaea? aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie
caiaeueieie i?ioeanaie.

6. Ia i?aenoaa? iaea?aeaieo ?acoeueoao?a ?ic?iaeoe ? ai?iaaaeeoe a
i?aeoeeo ?aeiiaiaeaoe?? ii ee?i?ei-eaai?aoi?i?e, ?ino?oiaioaeuei?e
ae?aaiinoeoe? ? aeeoa?aioe?eiaaiiio eiina?aaoeaiiio e?eoaaiith oai?eo c
aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie
i?ioeanaie aai?oae?e.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa ia iniia? aea/aiiy
iniaeeainoae ee?i?/iiai ia?aa?ao aaiioaeueiiai aiaeiiao?iico,
ii?aeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie, anoaiiaeaii, ui i?e
niieo/aii? aaiioaeueiiai aiaeiiao?iico c o?ii?/ieie caiaeueieie
i?ioeanaie niinoa??aathoueny a?eueo ae?aaeai? ii?ooaiiy iaino?oaeueii?
ooieoe??, aaia?ae?caoe?y aieth, noeeuei?noue aei ?aoeeaeoaaiiy, ci?ie
a?ioeaiico noaoaaeo i?aai?a, iecueea aoaeoeai?noue aacenii? oa?ai??.

Anoaiiaeaii, ui ii?aeiaiiy aaiioaeueiiai aiaeiiao?iico c o?ii?/ieie
caiaeueieie i?ioeanaie oa?aeoa?eco?oueny i?eioeeiiai ?ioeie ci?iaie
i?noeaai? ?ioiieia?/ii? ?aaeoeaiino? o aeaeyae? ??ceiai cieaeaiiy ai?noo
o oea?a?eaeueiiio neec? JgA, SJgA, JgG.

Aeiaaaeaii, ui o iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c
o?ii?/ieie caiaeueieie i?ioeanaie, a?aeaoaa?oueny ii?ooaiiy
ai?iiiaeueiiai aiiainoaco: a?ia?ano?iaai?y, a?ia?i?iaanoa?iiai?y oa
a?ia?i?ieaeoeiai?y o oie?eoe?iiao oaco oeeeeo. E??i oiai, aecia/a?oueny
aeai?an?y ooieoe?? ei?e iaaeie?iee?a.

Aia?oa i?iaaaeaia aeaeiaa ?aeaioeo?eaoe?y i?e a?eaeiaiio ian?iai?ii?
noaoaaeo oeyo?a o ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c
o?ii?/ieie caiaeueieie i?ioeanaie aai?oae?e, oa aea/aia aoaeoeai?noue
i?aia?aoo i?iaoooeei i?e e?eoaaii? oaeeo oai?eo.

Ia i?aenoaa? iaea?aeaieo aeaieo ?ic?iaeai? ? ai?iaaaeaeai? a i?aeoeeo
oaeineiiaeai? noaie aeeoa?aioe?eiaaiiai eiiieaeniiai e?eoaaiiy
iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie
caiaeueieie i?ioeanaie.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Io?eiai? aeai? aeaee
iiaeeea?noue ?ic?iaeoe oa ?aeiiaiaeoaaoe aeey ee?i?/ii? i?aeoeee
ae?aaiinoe/i? e?eoa??? aaiioaeueiiai aiaeiiao?iico, ii?aeiaiiai c
o?ii?/ieie caiaeueieie i?ioeanaie.

Ia i?aenoaa? anoaiiaeaieo iaoai?ci?a ?icaeoeo ii?ooaiue i?e?iaeiiai
a?ioeaiico i?oae, ai?iiiaeueiiai aiiainoaco, cieaeaiiy i?noeaaiai
?ioi?oaoo ?ic?iaeaii caaaeuei? i?eioeeie oa nenoaio ei?aeoe??, ye?
ia?aaeaa/athoue ye ii?iae?caoe?th ai?iiiaeueiiai oa ?ioiieia?/iiai
aaeaino, oae i e?ea?aeaoe?th a?eaeiaiai ian?iai?iiy noaoaaeo i?aai?a.

Anoaiiaeaii, ui cai?iiiiiaaia eiiieaenia noaia e?eoaaiiy caaacia/o?
a?eueo aenieee ??aaiue aoaeoeaiino?, cieaeo? /anoioo ?aoeeaeea?a oa
ni?ey? i?aeaeuaiith ineoinioe?aeueii? aaeaioaoe?? iiae?oaei?o ia? oa
a?aeiiaeaiith nioe?aeueii? ooieoe?? ae?iie.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy a i?aeoeeo. ?acoeueoaoe
aeine?aeaeaiiy oa ?ic?iaeai? iaoiaeeee ae?aaiinoeee ? e?eoaaiiy
ai?iaaaeaeai? a ?iaioo ae?ii/eo eiinoeueoaoe?e oa a?iaeieia?/ieo
a?aeae?eaiue i?noa Eoaainueea oa ?yaeo iaeanieo oeaio??a: Eueaiaa,
Caii??aeaey, Oa?eiaa, Noi.

Oai?aoe/i? iieiaeaiiy oa i?aeoe/i? ?aeiiaiaeaoe?? aeena?oaoe?eii? ?iaioe
aeeth/ai? a oeeee eaeoe?e oa i?aeoe/ieo caiyoue c a?iaeieia?? aeey
nooaeaio?a ia eaoaae?? aeooa?noaa oa a?iaeieia?? Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ? ia eaoaae?? aeooa?noaa oa
a?iaeieia?? iaaee/iiai oaeoeueoaoo Noinueeiai aea?aeaaiiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. Ieaioaaiiy ? i?iaaaeaiiy on?o
aeine?aeaeaiue aeeiiaii aeena?oaioii ca ia??iae c 1993 aei 1997?.
Iniaenoee aianie aaoi?a a caeiaooo? aeaieo ? iniiaiei ? iieyaa? o
naiino?eii c?a?aiiio iaoa??ae? ? aeeiiaii? a?eueoino? iaoiaeee,
ocaaaeueiaii? oa iaoeiaiio iaa?oiooaaii? oaeineiiaeaiiy iaoiae?a
ae?aaiinoeee oa ei?aeoe?? ii?ooaiue caei?ia’y i?e aeine?aeaeoaai?e
iaoieia??, i?iaaaeaii? aiae?co ia?aeiii? aeieoiaioaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeeeaaeai? ia tha?eaei?e eiioa?aioe??, i?enay/ai?e 60-??//th
Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai ?inoeoooo (Aeiiaoeuee, 1993);
Ieaioi? i?aae?iiy aeooa?ia-aiiaeieiaia Oe?a?ie «Ai?eii-caiaeuei?
i?ioeane a no/ani?e aeooa?nueei-a?iaeieia?/i?e i?aeoeoe?» (Caii??aeaey,
1995); O c’?cae? aeooa?ia-aiiaeieiaia Oe?a?ie (Iaeana, 1996); ia
iaoeiaeo eiioa?aioe?yo iieiaeeo a/aieo Noinueeiai aea?aeaaiiai
oi?aa?neoaoo (Noie, 1996, 1997).

?acoeueoaoe aeine?aeaeaiue iaaiai?ai? ia can?aeaiiyo eaoaae?e aeooa?noaa
oa a?iaeieia?? e?eoaaeueiiai oaeoeueoaoo oa a/aii? ?aaee Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (1997).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iaae?oeiaaii 7 iaoeiaeo ?ia?o,
c ieo: 3 – o i?ia?aeieo aeo?iaeao, 1 – o ca??ieeao iaoeiaeo i?aoeue, 3 –
o oacao iaoeiaeo eiioa?aioe?e oa eiia?an?a.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 155
noi??ieao iaoeiiieno, neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, aeaae
i?enay/ai?e iaoiaeai aeine?aeaeaiiy, i’yoe aeaa aeanieo aeine?aeaeaiue,
aiae?co oa ocaaaeueiaiith ?acoeueoao?a aeine?aeaeaiiy, aeniiae?a,
i?aeoe/ieo ?aeiiaiaeaoe?e oa nieneo aeei?enoaieo aeaea?ae, ye?e aeeth/a?
162 a?o/eciyieo ? 87 ca?oa?aeieo aeaea?ae, ye? caeiathoue 31 noi??ieo.
?iaioa ?ethno?iaaia 28 oaaeeoeyie ? 7 ?enoieaie, ye? caeiathoue 35
noi??iie.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeey ?ica’ycaiiy iinoaaeaieo caaea/
eiiieaenii ianoaaeaii 154 ae?iee, c ieo 94 — c aai?oaeueiei
aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie aai?oae?e
(iniiaia a?oia), 20 ae?iie — c o?ii?/iei caiaeueiei i?ioeanii aai?oae?e
(eiio?ieueia a?oia) ? 40 i?aeoe/ii caei?iaeo ae?iie.

Ioe?ieo nooiaiy ?iciianthaeaeaiinoi i?ioeano aeeiioaaee ca
eeaneo?eaoe??th, cai?iiiiiaaiith A.I. No?eaeaeiaui (1977) ?
aaeineiiaeaiith I.O. Eaueinueeei (1991). Aeey aa?eo?eaoe?? aai?oaeueiiai
aiaeiiao?iico aeei?enoai? niaoe?aeuei? aeine?aeaeaiiy, oae? ye
eieueiineiiiy, a?noa?inaeuei?iaia?ao?y, a?noa?ineii?y c ae?aaiinoe/iei
aeoe??aaiiyi aiaeioea?a?ena ? aiaeiiao??y c ianooiiei ii?oieia?/iei
aea/aiiyi aeoe??ao, eaia?ineiiiy c ioieoeieiith a?iin??th oa ianooiiei
ii?oieia?/iei aeine?aeaeaiiyi a?iioaoo, yaea?ii-iaai?oii-?aciiainio
oiiia?ao?th (ssI?), oeueo?icaoeiaa neaioaaiiy (OCAe).

Ooieoe?iiaeueiee noai a?iioaeaii-a?iio?ca?ii-y?/ieeiai? nenoaie aea/aii
ca aeiiiiiaith aecia/aiiy a ne?iaaooe? e?ia? ai?iii?a
?aae?i?ioiieia?/iei iaoiaeii c aeei?enoaiiyi ?aaaaio?a o??ie
«Cea-Ire-Sorin» (O?aioe?y) aeey aecia/aiiy i?ieaeoeio oa ?aaaaio?a
ae?iaieoeoaa ?inoeoooo i?aai?/ii? o?i?? «Aaea?onue»aeey ano?aae?ieo,
i?iaanoa?iio, oanoinoa?iio oa ei?oecieo.

Noai i?noeaaiai ?ioi?oaoo ioe?ithaaee ca ai?noii a oea?a?eaeueiiio neec?
IgA, SIgA, IgG, IgM ca iaoiaeeeith G.Manchini et al. (1965) c
aeei?enoaiiyi aioene?iaaoee a?o/eciyiiai ae?iaieoeoaa aei ie?aieo
?ioiiaeiaoe?i?a.

Aeey ae?aaiinoeee a?eaeiaiai ian?iai?iiy noaoaaeo oeyo?a aeei?enoai?
aaeoa??ineii?/iee, aaeoa??ieia?/iee ? eoeueoo?aeueiee iaoiaee
aeine?aeaeaiiy c aeei?enoaiiyi aeni?an — ae?aaiinoeee «I?eeoeueo-N»
(O?ieyiae?y).

?aeaioeo?eaoe?th eaiae?ae, ui aeniaaeeny, i?iaiaeeee oeyoii iiaoaeiae
a?io?i?/ieo ?yae?a (2% oeoe?o c iiieaaeaie: aetheica, naoa?ica,
iaeueoica, eaeoica, aaeaeoica).

Noai naenoaeueiiai caei?ia’y ianoaaeaieo iaoe??ioie aecia/aee ca
aeiiiiiaith niaoe?aeueieo naenieia?/ieo aeine?aeaeaiue. Aeey aea/aiiy
ee?i?/ieo i?iya?a ? iaoai?ci?a ?icaeoeo naenoaeueieo ?iceaae?a o ae?iie
canoinoaaee no?oeoo?iee aiae?c ?.E. Aioi?ai? (1977, 1983), a oaeiae
nenoaiii-no?oeoo?iee aiae?c naenoaeueii? aa?iii?? iiae?oaei?o ia?, ui
aoa ?ic?iaeaiee A.A.E?eooaeai (1985). Aeey ioe?iee naenoaeueii? ooieoe??
iiae?oaeaey aeei?enoiaoaaee iieooaaeueiee naenoaeueii? oi?ioee /ieia?ea
(NO*) ? naenoaeueii? oi?ioee ae?iee (NOAE), yeee ?ic?iaeaii A.N.
Aaneeue/aiei ? ?.E.Aioi?aith (1975, 1977).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. Aiae?c noaiiaeaiiy
iaino?oaeueii? ooieoe?? iieacaa, ui o ae?iie iniiaii? a?oie iaei i?noea
cai?ci?ea iaia?oa. Oea na?ae/eoue i?i ii?ooaiiy iae?iaoii?aeueieo
noinoie?a i?ae ei?ith aieiaiiai iiceo, aiiioaeaionii, a?iio?cii oa
y?/ieeaie i?ae /an noaoaaiai aeic??aaiiy. Aiaeia?/i? aeai? caeiaoo? ?
ae?oaeie aeine?aeieeaie (I.N. Aeaeeaei, 1993; A.A. Aecthaa, 1996; A.I.
No?eaeaeia, A.E. Aeaauaeia, 1996; A .I. Aeoeyaaa e niaao., 1997; A.
Palatynski, 1990; N.P. West, 1990).

E??i oeueiai, i?eaa?oa? aei naaa oaaao oaeo o?eaaeiai noaiiaeaiiy
iaino?oaeueii? ooieoe??, ui oaeiae i?aeoaa?aeaeo? ai?iiiaeueiee
aeenaaeain a i?a — , ? ioaa?oaoiiio a?oe? oaeeo ae?iie.

Aea/aiiy iniaeeainoae iaino?oaeueiiai oeeeeo iieacaei, ui a iiiaio
ianoaaeaiiy ia ii?ooaio iaino?oaeueio ooieoe?th iaee eeoa 3,2%
iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie
caiaeueieie i?ioeanaie (p<0,05) a ii??aiyii? c a?oiith caei?iaeo ae?iie, oa a?oiith eiio?ieth. Oa?aeoa?ecoth/e ii?ooaiiy iaino?oaeueii? ooieoe?? o iaoe??ioie iniiaii? a?oie, iaiao?aeii caa?iooe oaaao ia oa, ui o a?eueoino? c ieo niinoa??aaeinue ii?ooaiiy ?? ii oeio aeueaiaeeniaii?a? - 86,2%, a?ia?iie?iaii?a? - 55,3% , ia?aae- ? i?neyiaino?oaeueieo aeae?eaiue - 56,4%. Aiae?c ?ai?iaeoeoeaiiai caei?ia’y ianoaaeaieo iniiaii? a?oie iieacaa, ui aiii aoei ii?ooaiei o 41,5 a?aenioe?a ae?iie. Ia?aeiia iaie?aei?noue a?aecia/aeany o 18,1% aeiaaee?a, aoi?eiia - o 22,4 a?aenioe?a iaoe??ioie. I?ioa o a?eueoino? ae?iie iaoiaaiaoe/ieie ne?ae aaaaeaoe ia?aianai? aai?oe (55,5%). Aaa?oi?noue, ui cae?i/eeanue iieiaaie, a?aei?/aii o 42,5% ae?iie, iicaiaoeiao aaa?oi?noue cono??ee o 6,7% aeiaaee?a. I?iaaaeai? aeine?aeaeaiiy a?aeiia?aeathoue a?aeiiei aeaiei e?oa?aoo?e (A.I. Aaneaeia, 1990; I.I. Aeaie?ia, 1991; I.O. Eaueineee, 1991; A.A. A?iae , 1994), ca?aeii yeeo i?ney iieia?a cieea? i?ioa?ie ?aoeeoey?ieo aieieii a ca’yceo c i?ioeanaie ?aaaia?aoe?? ? a?aeaoaa?oueny aaciina?aaei?e eiioaeo i?ae aiaeiiao?i?i oa i?iiao???i, ui ? ni?ey? aeieeiaiith aiaeiiao?iico. A?aeiii, ui a aaiaci ?yaeo caoai?thaaiue aaaeeeaa cia/aiiy iathoue oai?iae, ia?aianai? a aeeoeinoa?, iniaeeai i?ae /an noaoaaiai aeic??aaiiy, a aaia?aoeaiiio a?oe?. Aea/aiiy niiaoe/iiai aiaiiaco iieacaei, ui o ae?iie iniiaii? a?oie a?aecia/a?oueny aenieee ?ioaeoe?eiee ?iaeaen o aeeoeinoa? oa aaeeea ieoiia aaaa o??o?a?/ieo ao?o/aiue ia i?aaiao /a?aaii? ii?iaeieie (iniaeeai aiaiaeaeoii?e) i?ae /an noaoaaiai aeic??aaiiy. Na?aae aeno?aaaiioaeueii? iaoieia?? iae/ano?oa cono??/aeeny ia?aia? oai?iae (71,3%) oa oeoieiai-eeoeiai caoai?thaaiiy (69,1%), na?aae yeeo oai?iae ia/?iee oa aeia/ieo oeyo?a (63,8%) ?iciiae?eyee ae?oaa i?noea c aea?a?/ieie oai?iaaie, a o?ao? i?noea iin?aeaee caoai?thaaiiy i?aai?a aeeoaiiy (53,2%), /aoaa?oa - na?oeaai-noaeeii? (45,7%) oa aiaeie?eii? caoai?thaaiiy (43,6%). Ioaea, oe? aeine?aeaeaiiy iieacaee, ui a?eueo?noue ianoaaeaieo ae?iie iaee iani?eyoeeaee i?aii?a?aeiee oii, ia ui i?eaa?oathoue oaaao ? ?io? aaoi?e (N.A. Ia?/oe, 1992; I.I. Eocueieia, 1993; D.G. Adamson, 1990; R. L . Barbieri, 1990) . Aecia/aiiy i?e/ei ?icaeoeo aiaeiiao?iico iieacaei iie?ao?ieia?/i?noue ?i?oe?eiaaieo /eiiee?a. Ca iaoeie aeaieie, o a?eueoino? ae?iie iniiaii? a?oie (64,9%) a aiaiiac? ia?aaaaeaee o?ii?/i? caiaeuei? i?ioeane a i?eaeaoeao iaoee, caiaeuei? i?ioeane i?ney aai?o?a (21,3%), i?neyiieiaia? caoai?thaaiiy (11,7%) oa caiaeuei? oneeaaeiaiiy aioo??oiueiiaoeiai? eiio?aoeaioe?? (2,1%). Aiae?c ?ai?oa aeei?enoiaoaaiiai e?eoaaiiy iieacaa, ui aaaaoi ae?iie iaiaa?oioiaaii i?eeiaee aioea?ioeee, a?inoeioeyoi?e, ui iiaei iaaaoeaii aieeiooe ia ?ioiio nenoaio oa a?ioeaiic i?oae. Oa?aeoa?ii, ui o?eaaeee /an ae?iee io?eioaaee i?ioecaiaeueia e?eoaaiiy aac nooo?aiai aoaeoo. Iaeiei ?c aeii?iaioieo ? iaea?eueo no?eeeo i?iya?a aaiioaeueiiai aiaeiiao?iico a ii?aeiaii? c o?ii?/ieie caiaeueieie i?ioeanaie aoa a?eue. Anoaiiaeaii, ui aieueiaee neiae?ii a ia??iae iai?oanoaoe?? a?aecia/aany o an?o iaoe??ioie ? iinea aaia?aeiciaaiee oa?aeoa?. O eiaeii? ae?oai? ae?iee iniiaii? a?oie a?eue noi?iaiaeaeoaaany aaaaoaoeaieie ?iceaaeaie (ioaeioith, aieiaie?oae?iiyi, aieiaiei aieai, i?aeaeuaiiyi a?oa??aeueiiai oeneo, oiui), ui ia aeoieo E. O. Oeiea?aai? ? ni?aaao. (1989) , I. I. Eocuei?ii? (1993) ,N. A. Oaae??ia (1991, 1994) ? iieacieeii aeeaeiieo iae?iaeeno?ioi/ieo i?ioean?a a oaciaeo ia?aiaeo nieao?iiyo. A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue aaeaeiny anoaiiaeoe aca?iio caeaoi?noue aaiioaeueiiai aiaeiiao?iico i o?ii?/ieo caiaeueieo i?ioean?a i?aeo?eioaaoe aeoeai?noue oa iaoyaeoaaoe ia?aa?a iaio iaoieia?/ieo i?ioean?a. Oae, iaie anoaiiaeaii, ui aaiioaeueiee aiaeiiao?iic aeeeeea? oa i?aeo?eio? aeoeai?noue o?ii?/iiai caiaeueiiai i?ioeano. A naith /a?ao, caaino?aiiy o?ii?/iiai caiaeueiiai i?ioeano ni?ey? aeoea?caoe?? aiaeiiao?iico. ?acoeueoaoe aeine?aeaeaiue ni?aiaaeathoue c aeaieie, iaaaaeaieie a e?oa?aoo?? (A. I. Aaneaeia , 1990) . I?eioeeiiai aaaeeeai a?aecia/eoe, ui iaeiei ?c eaioetha?a a iaoiaaiac? aaiioaeueiiai aiaeiiao?iico, ii?aeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie, ? ii?ooaiiy oeaio?aeueii? ?aaoeyoe?? aiiioaeaii-aiiioica?ii-y?/ieeiaeo aca?iia?aeiioaiue. Ia?o ca ana i?eaa?oathoue aei naaa oaaao caeiaoo? aeai? i?i iniaeeaino? nae?aoe?? i?ieaeoeio o iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie. Ca?aeii ?aeiiaiaeaoe?? AIIC (1986) aea/aiiy ??aiy i?ieaeoeio a ne?iaaooe? e?ia? ? ae??oaeueiei a o?aeoiaoe? iae?iaiaeie?eiieo ii?ooaiue o ae?iie (ss.N. AEa?iiaay, 1995; A.I. Caii?iaeai, I.?. Oeaaaeuenueeee, 1996; A. I. Aeoeyaaa e niaao., 1997) . Aacaeueiee ??aaiue i?ieaeoeio o ae?iie c aaiioaeueiei aiaeiiao??icii a ii?aeiaii? c o?ii?/ieie caiaeueieie i?ioeanaie aoa cia/ii aeua o oie?eoe?iia?e oac? iaino?oaeueiiai oeeeeo (?< 0,05) a ii??aiyii? c eiio?ieueiith oa a?oiith caei?iaeo iaoe??ioie. Ii?yae c ii?ooaiiyi nae?aoe?? i?ieaeoeio o aeine?aeaeoaaieo ciaeaeaii ii?ooaiiy aaeaino ae?ii/eo noaoaaeo ai?iii?a: i?aeaeuaiee ai?no ano?aae?ieo a iaeaea? oace iaino?oaeueiiai oeeeeo oa i?aeaeuaiiy ??aiy i?iaanoa?iio a oie?eoe?iiao oaco. Aeey anoaiiaeaiiy iiaeeeaiai acaaiica’yceo i?ae ci?iaie ??aiy i?ieaeoeio oa ano?aae?ieo o ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, ianoaaeai? a caeaaeiino? a?ae ??aiy i?ieaeoeio aoee ?iciiae?eai? ia aea? a?oie. A ia?oo a?oio aeeth/aii 84 ae?iee, o yeeo ??aaiue i?ieaeoeio ia a?ae??ciyany a?ae o?c?ieia?/ieo ii?i (211, 95 ± 10,6 iII/ie). Ae?oao a?oio neeaee 10 iaoe??ioie c i?aeaeuaiei ??aiai i?ieaeoeio (977,26 ± 48,9 iII/ie). Iaeii/anii o ae?iie aecia/aany ??aaiue ano?aae?ieo. Anoaiiaeaii, ui a ia?o?e a?oi? iieacieee i?ieaeoeio ia a?ae??ciyeenue a?ae oaeeo o caei?iaeo ae?iie, aea iacaaaeath/e ia oea ??aaiue ano?aae?ieo aoa i?aeaeuaiei (2,57 ± 0,1 i iieue/e) a ii??aiyii? c eiio?ieueiith a?oiith oa a?oiith caei?iaeo ae?iie (?< 0,05). I?ioa o iaoe?aioie c aai?oaeueiei aiaeiiao??icii a ii?aeiaii? c o?ii?/ieie caiaeueieie i?ioeanaie c i?aeaeuaiiei ai?noii i?ieaeoeio iaea i?noea oaiaeaioe?y aei cieaeaiiy ai?noo ano?aae?ieo (0,21 ±0,01 i iieue/e). Ia i?aenoaa? caeiaooeo ?acoeueoao?a iiaeia i?eionoeoe, ui a ?aaoeyoe?? iaino?oaeueiiai oeeeeo a?iioaeaion a?ae?a?a? ia?ieneaio ?ieue, oiae? ye ?aaoeyoe?y oeeee?/ii? nae?aoe?? aiiaaeio?iiei?a eiio?ieth?oueny ia?aaaaeii ia a?iio?ca?iiio ??ai? ai?noii ano?aae?ieo oa i?iaanoa?iio a ia?eoa??eiiio e?iaiia?ao. Oe? aeai? ocaiaeaeothoueny c aeaieie e?oa?aoo?e (A. I. Aeoeyaaa e niaao., 1997). I?eaa?oaei aei naaa oaaao cieaeaiiy ??aiy oanoinoa?iio oa ei?oecieo o iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, a ii??aiyii? c oaeeie o caei?iaeo ae?iie, ui iiaea na?ae/eoe i?i cieaeaiiy aaeaioaoe?eieo iiaeeeainoae i?aai?cio iaoe??ioie iniiaii? a?oie ? aeeeoo? iaiao?aei?noue iiaeoeyoe?? ie?aieo eaiie ye aiaeie?eiii?, oae i aaeaioaoe?eii? a?aeiia?ae? i?e aeine?aeaeoaai?e iaoieia??. Ioaea, iiaeia ocaaaeueieoe, ui a iniia? aiaeie?eiieo ii?ooaiue i?e aaiioaeueiiio aiaeiiao?iici, ii?aeiaiiio c o?ii?/ieie caiaeueieie i?ioeanaie eaaeaoue ??ci? ca /anii, i?iyaii i noooth aeieeath/eo ci?i iaoai?cie ii?ooaiiy aiiioaeaii-aiiioica?ii-y?/ieeiai-iaaeie?eiai? nenoaie, ye? i?eaiaeyoue aei aiia?ano?iaaiaii?, a?ia?i?iaanoa?iiai?? ? a?ia?i?ieaeo?iai?? o oie?eoe?iiao oaco oeeeeo oa cieaeaiiyi eiioeaio?aoe?? oanoinoa?iio oa ei?oecieo. Caeiaoo? iaie ?acoeueoaoe aeine?aeaeaiue i?i i?aeaeuaiiy ia/?ieiai? oa?iaioii? aeoeaiino? na?ae/aoue i?i ooieoe?iiaeueio iai?oao aaiaoiaieia?ii? nenoaie i?e aaiioaeueiiio aiaeiiao?iici a ii?aeiaii? c o?ii?/ieie caiaeueieie i?ioeanaie. A oaia??oi?e /an aeia?a aeiaaaeaia iaoiaaiaoe/ia ?ieue ?ioiieo /eiiee?a ye i?e aaiioaeueiiio aiaeiiao?iici, oae i i?e caiaeueieo i?ioeanao ae?ii/eo noaoaaeo i?aai?a (E.ss. Noi?oi e niaao., 1990; E.A. Aeoeaiei, 1991; E.A. Euaiei, 1991; I.O. Eaueineee, 1991; I.E. Aaeen, 1992; I.I. Eocueieia, 1993; W.P. Domowski et al., 1989; Ph. C. Galle, 1989; W. Kowalski, R. Czekanowski, 1989). Aeoiea i?i aaoiiiii?noue ooieoe?iioaaiiy nenoaie caoenoo, ui caaacia/o? i?noeaaee ?ioi?oao neeciaeo iaieiiie, aoea aia?oa cai?iiiiiaaia ss.N. Oaa?oeiaiii, E.A. Oacainiiii (1978), A.A. Caeeinueeei (1980). Oea ia o?eueee ia i?ioe?i/eoue caaaeuei?e eiioeaioe?? ?ioi?oaoo, aea e cia/ii ?icaeaa? ??. Nooo?aei eaioethaii i?iyao i?noeaaiai ?ioi?oaoo a ae?ii/eo noaoaaeo i?aaiao, a?ae /iai caeaaeeoue ?ai?iaeoeoeaia ooieoe?y, ? oe?/iee /eiiee. ?acii c oei, iiaeia ia?ae?/eoe eeoa ie?ai? ?iaioe i?i noai i?noeaaiai ?ioi?oaoo i?e aaiioaeueiiio aiaeiiao?iici, ii?aeiaiiio c o?ii?/ieie caiaeueieie i?ioeanaie aaiioaeie (I.I. Eocueieia, 1993) , oiio iao? aeine?aeaeaiiy iiiiaiththoue oeth i?iaaeeio. sse iieacaee i?iaaaeai? iaie aeine?aeaeaiiy, o oai?eo c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, aeyaeai? nooo?a? ii?ooaiiy i?noeaai? ?ioiieia?/ii? ?aaeoeaiino? o aeaeyae? cieaeaiiy ai?noo ?ioiiaeiaoe?i?a A, SA, oa G o oea?a?eaeueiiio neec? (oaae. 1), ui iaoiiaeth? iaiao?aei?noue aeei?enoaiiy o oaeeo oai?eo cania?a oa iaoiae?a i?aeaeuaiiy i?noeaai? ?ioiieia?/ii? ?aaeoeaiino?. Oaaeeoey1 - Ai?no oea?aieaeueieo ?ioiiaeiaoe?i?a (a/e) o ianoaaeaieo iaoe??ioie (Mm) IieacieeIniiaia a?oia (n - 94)Eiio?ieueia a?oia (n - 20)Caei?ia? iaoe??ioee (n - 40) JgA a/e0,22 0,01 # **0,56 0,03 # 0,36 0,02 SJgA a/e0,16 0,01 # **0,30 0,01 # 0,54 0,03 JgG a/e0,27 0,01 # **0,48 0,02 # 0,29 0,01 JgM a/e0,17 0,01 0,15 0,01 -I?ei?oee: 1. # p<0,05 - a ii??aiyii? c a?oiith caei?iaeo 2. ** p<0,05 - ii??aiyii? c eiio?ieueiith a?oiith Cieaeaiiy ?ioiieia?/ii? ?aaeoeaiino? i?aai?cio ii?ooo? i?e?iaeiee a?ioeaiic i?oae. I?e/iio, naia ii?ooaiiy ?ioiii? nenoaie iaoiiaeth? iaoiaaii?noue oa iii?ooi?noe/i?noue a?ea?a, ye? ?ai?oa aaaaeaeeny iaiaoiaaiieie (?.I. ?aa?iaa, 1989; I.A. Ia?oui/oe, 1991; A. Budak, A. Mucura, 1985; W. Mendeling, V. Kolovsky, 1989). Oea aoei i?aeoaa?aeaeaii oeioaaiiyi aaa?iaeueiiai nae?aoo ia eaiaeeaeic. Aeiaaaeaii, ui o 60,6 a?aenioea ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, aeyaeai? a?eae ?iaeo Candida i?e eoeueoo?aeueiiio aeine?aeaeaii?, oiae? ye i?e aaeoa??ineii?/iiio - eeoa o 36,2 % aeiaaee?a. Ioaea oi/i?noue ae?aaiinoeee a?ea?a ?iaeo Candida caeaaeeoue a?ae iaoiaeo oeioaaiiy. Aeaeiaa ?aeaioeo?eaoe?y ae??aeaeaeaiiae?aieo a?ea?a ca ?oiueith oeoe?ieioe/iith aeoeai?noth iieacaea, ui iae/ano?oa caoaeieeii eaiaeeaeico ? Candida albicans (55,3%), iaioa (22,3%) - Candida intermedia, oa iiae?eythoue i?ae niaith /anoioo (11,2%) - Candida krusei oa Candida viswanathii. Aa?oi aeiaeaoe, ui a?eae ?iaea Candida ?cieueiaaii a i?e?ieoeueoo?? cono??/aeeny ??aeei. *ano?oa iaea i?noea anioe?aoe?y a?ea?a ?iaea Candida c cieioenoei oa ai?aea?iaeueiei noao?eieieii - 38,0% ae?iie iniiaii? a?oie oa c eeoeiaith iaei/eith (Esch. coli) - 28,0%. Io?eiai? aeai? ni?aiaaeathoue c aeaieie e?oa?aoo?e (A.A. Aai?iaa, I.A. Ieenea? 1988., I.A. Ia?oui/oe 1991., A.E. Ie?caaaeaaaa 1992). Iaie aia?oa aeine?aeaeaii noai naenoaeueii? ooieoe?? iiae?oaei?o ia?, ae?iee yeeo no?aaeaeaee aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie. I?iaaaeai? aeine?aeaeaiiy iieacothoue, ui noai ?ai?iaeoeoeaiiai caei?ia’y c ineoio?aaioth/ei eiiiiiaioii ? /eiieeii naenoaeueii? aeenooieoe?? ? naenoaeueii? aeenaa?iii?? . Aeey ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, oeiiaith aoea a?iinaenoaeuei?noue, aea aiia iaea a?aeiiniee oa?aeoa?. ?iceaaee naenoaeueii? ooieoe?? o iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, coiiaeai? aieeaii nioe?aeueieo, ineoieia?/ieo oa nioe?aeueii-ineoieia?/ieo /eiiee?a ia oe? ai?iiiaeueieo oa ?ioiieia?/ieo ii?ooaiue, ui iia’ycaii c iniiaiith iaoieia??th o ae?iie. Ia i?aenoaa? caeiaooeo iaie aeaieo i?i aaaaoiii?iee iaoai?ci ii?ooaiue i?e aaiioaeueiiio aiaeiiao?iici, ii?aeiaiiio c o?ii?/ieie caiaeueieie i?ioeanaie, ie i?eeoee aei aeniiaeo, ui e?eoaaiiy ae?iie c iacaaiith iaoieia??th iio?aao? nenoaiiiai i?aeoiaeo. Aeeeaaeai? iaoa??aee aecia/eee iaiao?aei?noue aeeth/aiiy aei caaaeueiii?eeiyoiai a ee?i?oe? e?eoaaiiy aaiioaeueiiai aiaeiiao?iico, ii?aeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie, aioo??oiueinoaeeiiiai eaca?iiai ii?ii?iaiiy e?ia? (AEIE) oa i?iaoooeeio, ni?yiiaaieo ia ii?iae?caoe?th i?noeaaiai ?ioi?oaoo oa a?ioeaiico i?oae. Aoaeoeai?noue aeaii? oa?ai?? aea/aia o 94 ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie. A ca’yceo c oei, ui ai?iiiaeueia oa?ai?y aioo??oiueiai aiaeiiao??ico o?ea iaoee aeei?enoiao?oueny o?eueee i?e ae?oaiio nooiai? eiai iioe?aiiy, aeey ianoaaeaiiy aoee a?ae?a?ai? ae?iee c aeeoociei aiaeiiao??icii o?ea iaoee ae?oaiai nooiaiy, iiaaeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie. C ieo ia?oo a?oio neeaee 30 iaoe??ioie, ye? io?eioaaee caaaeueiii?eeiyoa e?eoaaiiy, ae?oao a?oio - 64 ae?iee, ye? io?eioaaee ii?yae c caaaeueiii?eeiyoei e?eoaaiiyi eiiieaenio oa?ai?th, iai?aaeaio ia i?aeaeuaiiy i?noeaaiai ?ioi?oaoo (AEIE), oa naiaoe?th o?ii?/ieo i/aa?a eaiaeeaeico i?ioea?eaeiaei i?aia?aoii i?iaoooeei. Aaa?iaeuei? noiiceoi??? i?iaoooeeio, eiaeia c yeeo i?noeoue 100 ia. iaoai?oeeio, i?ecia/aee ii iaei?e ia i?/ oi?iaeiaae 3 aai 6 aei?a, caeaaeii a?ae nooiaiy oyaeeino? oa o?eaaeino? ee?i?/ieo iciae eaiaeeaeico noaoaaeo oeyo?a. I?e iaaeinoaoi?e aoaeoeaiino? aaa?iaeueieo noiiceoi???a i?iaoooeeio i?ecia/aee oaaeaoee i?iaoooeeia per os ii 1 oaaeaooe? (100 ia.) 4 ?ace ca aeiao ai?iaeiaae 10 aei?a. Iaeii/anii a iaia’yceiaiio ii?yaeeo i?iaiaeeee naiaoe?th noaoaaiai ia?oia?a. Oa?aeoa?iith iniaeea?noth i?ioeaii?eioe/ii? ae?? iaoai?oeeio ? eiai aeai?/a ni?iiiaei?noue iacai?ioiuei ca’ycoaaoeny c a?ainoa??iii ee?oeiii? iaia?aie ae??aeaeaeaaeo oa ?ioeo a?ea?a, ii?oooy i?e oeueiio i?iieei?noue ee?oeie (A.A. Aai?iaa, I.A. Ieinea?, 1988; A. I. I?eeaineay, A.A. Ieeoca, 1994; A. Gosz, T. Mach, 1989; W. Gehring, W. Spate, 1990). Aeoaea aaaeeeaith ye?noth i?aia?aoo ? a?aenooi?noue aea?a?/ieo ?aaeoe?e (A.I. I?eeaineay, A. A. Ieeoca, 1994), ui aea? iiaeeea?noue a?eueo oe?ieiai canoinoaaiiy eiai o iaoe??ioie, o yeeo niinoa??aaaoueny i?aeaeuaia /ooeea?noue aei iaaeeeaiaio?a. AEIE i?iaiaeeee aae?e-iaiiiaei eaca?ii EAI-lll (c i?oei?noth ii?ii?iaiiy ia aeoiae? ?c na?oeiaiaeo 1,5 iAo). O?eaae?noue i?ioeaaeo?e caeaaeaea a?ae noaio iaoe??ioee ? i?iaeiaaeoaaeanue 20-40 oaeeei. E?euee?noue i?ioeaaeo? eieeaaeanue a?ae 5 aei 10. sse a?aeiii, iaeiei c i?ia?aeieo ? iaea?eueo no?eeeo aeya?a aaiioaeueiiai aiaeiiao?iico, ii?aeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie, ? aieueiaee neiae?ii. Aeai? ee?i?/iiai niinoa?aaeaiiy ca iaoe??ioeaie, ye? iaea?aeoaaee oa?ai?th ca cai?iiiiiaaiith iaie noaiith, na?ae/aoue i?i oa, ui o 62,5% ae?iie aeinyaiooi iiaiee ciaaiethth/ee aoaeo, o 31,3% aie? ciaioeeeny, o 61,1±10,1% iaoe??ioie aaea i?ney 2-3 naain?a a?aecia/aeiny iie?auaiiy caaaeueiiai noaio oa o 65,2±9,4% niinoa??aaany caniieithth/ee aoaeo. Ciaaiethth/ee aoaeo i?ae aieeaii AEIE c’yaeyany ia 4 aei? ?ai?oa, i?ae ca o?aaeeoe?eieie noaiaie e?eoaaiiy. I?i iiceoeaiee aoaeo ?ic?iaeaii? iaie noaie e?eoaaiiy na?ae/eei ? a?aeiiaeaiiy ooioe?iiaeueiiai noaio aiiioaeaii-aiiioica?ii-y?/ieeiai? nenoaie, i?i ui iiaeia aoei noaeeoe ii a?aeiiaeaiith iaino?oaeueii?, iaoeyoi?ii? ooieoe?e, oa ca aeaieie nae?aoe?? i?ieaeoeio, ano?aaeiieo, i?iaanoa?iio, oanoinoa?iio oa ei?oecieo a ieaci? e?ia? o an?o aeine?aeaeoaaieo iaoe??ioie. Anoaiiaeaii, ui a ae?oa?e a?oi? i?ney e?eoaaiiy ca cai?iiiiiaaiith noaiith a?aeiiaeaiiy iaino?oaeueiiai oeeeeo a?aeaoaaeiny o 73,5% aeiaaee?a, a oie /an ye a ia?o?e a?oi?, i?ney e?eoaaiiy ca o?aaeeoe?eiith noaiith aiaeia?/iee aoaeo aeinyaiooi eeoa o 43,3% (p<0,05). O?eaae?noue iaino?oaoe?? ciaioeeanue c 7 aei 3,4±1,2 aei?a. Iiae aieeaii eiiieaeniiai e?eoaaiiy niinoa??aaeeny oaeiae iiceoeai? ci?ie aiaeie?eiieia?/ieo iieaciee?a, ui na?ae/eei i?i aaeaeaaoi?noue aeei?enoaii? oa?ai??. O iaoe??ioie ia?oi? a?oie, o yeeo e?eoaaiiy i?iaiaeeee ca o?aaeeoe?eiith oi?iith, ??aaiue i?ieaeoeio oa ei?oecieo ia a?ae??ciyany a?ae aiaeia?/ieo iieaciee?a caei?iaeo ae?iie. A oie aea /an eiioeaio?aoe?y ano?iaai?a oi/ ? cieaeoaaeanue ii??aiyiii c iieacieeaie aei e?eoaaiiy, iaeiae ia aeinyaaea aaee/ei, oa?aeoa?ieo aeey caei?iaeo ae?iie, oi/a ??aaiue i?iaanoa?iio ae??n. Iaea?eueo cia/ei? iiceoeai? ci?ie a a?iioaeaii-a?iio?ca?ii-y?/ieeia?e nenoai? aoee o iaoe??ioie i?ney e?eoaaiiy ca cai?iiiiiaaiith iaie noaiith. I?e oeueiio ii?iae?ciaaany i?aeaeuaiee aei ii/aoeo e?eoaaiiy ??aaiue i?ieaeoeio, a eiioeaio?aoe?y ano?aae?ieo oa ei?oecieo ia a?ae??ciyeenue a?ae iieacieea caei?iaeo ae?iie; aenieee ai?no i?iaanoa?iio a e?ia? ei?aethaaa c aenieith aoaeoeai?noth e?eoaaiiy. A?eueo ae?aaeaiee aieea ia ooieoe?iiaeueiee noai aaiaoia?e?a?ii? nenoaie, ?? oa?iaioaoeaii? ooieoe?? ni?aaeea eiiieaenia oa?ai?y ca cai?iiiiiaaiith noaiith, i?i ui na?ae/eei a??ia?aeia cieaeaiiy iieaciee?a AnAO, AeAO, aaoa-e?iii?ioa?ae?a a ii??aiyii? c a?oiith iaoe??ioie, ui iaea?aeoaaee o?aaeeoe?eia e?eoaaiiy. Cai?iiiiiaaia iaie eiiieaenia e?eoaaiiy nooo?ai aieeaaei ia nae?aoe?th oea?aieaeueieo iioiiaeiaoeiiia (oaae. 2). O aeine?aeaeoaaieo iaoe??ioie nae?aoe?y oea?aieaeueieo ?ioiiaeiaoe?i?a A, SA, G noaoenoe/ii aeinoia??ii i?aeaeuoaaeany i i?ney cae?i/aiiy eo?no e?eoaaiiy ia a?ae??ciyeany a?ae oaeeo iieaciee?a o caei?iaeo in?a (p>0,05). Ie
aaaaea?ii, ui a ia?oo /a?ao cai?iiiiiaaiee iaie eiiieaen oa?ai??
caaacia/o? ii?iae?caoe?th ai?iiiaeueieo iieaciee?a ? a?ioeaiico.
Ianooiiei aoaiii ?aae?caoe?? e?eoaaeueiiai aoaeoo aeei?enoaii? oa?ai?? ?
ii?iae?caoe?y neioaco SIgA aiane?aeie onoiaiiy iniiaieo i?e/ei,
iaoiiaethth/eo ?icaeoie ? i?aeo?eieo ?ioiiaeao?oeeoo.

A oie aea /an o ae?iie, yeeo e?eoaaee ca o?aaeeoe?eiith noaiith,
niinoa??aaeany iiceoeaia aeeiai?ea nae?aoe?? oea?aieaeueieo
iioiiaeiaoeiiia, i?ioa an? iieacieee caeeoaeeny cia/ii ieae/eie, i?ae o
caei?iaeo ae?iie (p<0,05). Eiiieaenia e?eoaaiiy ca cai?iiiiiaaiith noaiith /eieei iioiiei?eaoth/o ae?th, cie?aia ni?eyei e?ea?aeaoe?? aeenaaeaino eaioetha?a i?noeaaiai ?ioi?oaoo, /ei, iiaeeeai, i iiynith?oueny a?eueo oaeaeea ee?i?/ia icaei?iaeaiiy iaoe??ioie. Oa?ai?y i?iaoooeeiii aoea aoaeoeaiith o 90,6 a?aenioe?a ae?iie c aaiioaeueiei aiaeiiao?iicii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie aai?oae?e. *a?ac 6 i?nyoe?a ?aoeeaeeae niinoa??aaeeny eeoa o 6,25% aeiaaee?a. I?ney i?iaaaeaiiai e?eoaaiiy ca cai?iiiiiaaiith noaiith a?aeaoaaeiny i?aeaeuaiiy ineoieia?/ii? aaeaioaoe?? iiae?oaei?o ia? oa a?aeiiaeaiiy naenoaeueii? ooieoe?? o ae?iie c aaiioaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie. Ineoinioeiaeueio aaeaioaoe?th iiae?oaeaey aeinyaiooi o 73,8 a?aenioe?a iiae?oaei?o ia?. Oaaeeoey 2 - Iieacieee i?noeaaiai ?ioi?oaoo o iaoe??ioie c aai?oaeueiei aiaeiiao??icii (AA), ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie (OCI) i?ney eiiieaenii? oa?ai?? (I ±m) A?oia ianoaaeaieo iaoe??ioieE?euee?noue ianoaaeaieo (n)JgA a/eSJgA a/eJgG a/eJgM a/e1.Iaoe??ioee c AA, ii?aeiaiei c OCI aei e?eoaaiiy940,22±0,01 # **0,16±0,01 # **0,27±0,01 # **0,17±0,012.Iaoe??ioee c AA, ii?aeiaiei c OCI i?ney e?eoaaiiy ca o?aaeeoe?eiith noaiith300,26±0,01 # *0,19±0,01 # *0,27±0,01 # **0,16±0,013.Iaoe??ioee c AA, ii?aeiaiei c OCI i?ney eiiieaenii? oa?ai?? ca i?iiiiiaaiith noaiith640,32±0,02 * **0,51±0,03 * **0,30±0,02 *0,05±0,003 *4.Caei?ia? iaoe??ioee400,36±0,020,54±0,030,29±0,01-I?ei?oee: 1. # p<0,05 — a ii??aiyii? c caei?iaeie iaoe??ioeaie 2. * p<0,05 — a ii??aiyii? c a?oiith iaoe??ioie aei e?eoaaiiy 3.** p<0,05 — a ii??aiyii? c a?oiith iaoe??ioie i?ney e?eoaaiiy ca o?aaeeoe?eiith noaiith Oaeei /eiii, aeei?enoaiiy a eiiieaeni?e oa?ai?? ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, AEIE oa i?iaoooeeio aeicaiey? nooo?ai cieceoe ee?i?/i? i?iyae caoai?thaaiiy, ni?ey? ii?iae?caoe?? aiaeie?eiii? ooieoe?? a?iio?ca, y?/iee?a, iieaciee?a i?noeaaiai ?ioi?oaoo, ii?iae?caoe?? i?e?ioei?e i?oae, i?aeaeuaiith ineoinioeiaeueii? aaeaioaoe?? iiae?oaei?o ia? oa a?aeiiaeaiith naenoaeueii? ooieoe?? ae?iie. Ioaea, noaia e?eoaaiiy ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, iiaea aooe ?aeiiaiaeiaaia aeey i?aeoe/ii? ioi?iie caei?ia’y. A E N I I A E E 1. I?e aai?oaeueiiio aiaeiiao??ic?, ii?aeiaiiio c o?ii?/ieie caiaeueieie i?ioeanaie, o ae?iie niinoa??aa?oueny neiae?ii "aca?iii? iaoyaeaiino?" ee?i?/iiai i?iyao, ui i?ecaiaeeoue aei o?eaaeiai ia?aa?ao iaio caoai?thaaiue oa aaia?ae?caoe?? aieth, ?iceaaeo iaino?oaeueii? ooieoe??, ?ai?iaeoeoeaiiai oa naenoaeueiiai caei?ia’y. 2. Ooieoe?iiaeueiee noai a?iioaeaii-a?iio?ca?ii-y?/ieeiai? nenoaie o iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, oa?aeoa?eco?oueny ii?ooaiiyi ai?iiiaeueiiai aiiainoaco a a?e a?ia?ano?iaai??, a?ia?i?iaanoa?iiai?? ? a?ia?i?ieaeo?iai?? o oie?eoe?iiao oaco oeeeea, oa cieaeaiiyi eiioeaio?aoe?? oanoinoa?iio ? ei?oecieo. 3. O iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, i?eai?/o?oueny i?noeaaee ?ioi?oao: a?aeaoaa?oueny cieaeaiiy ai?noo a oea?a?eaeueiiio neec? ?ioiiaeiaoe?i?a A, SA, G oa iiyaa IgM. 4. Aaiioaeueiee aiaeiiao?iic, ii?aeiaiee c o?ii?/ieie caiaeueieie i?ioeanaie, noi?iaiaeaeo?ony ii?ooaiiyi i?e?iaeiiai a?ioeaiico i?oae oa ni?ey? ?icaeoeo eaiaeeaeicii? ?ioaeoe?? o 60,6% aeiaaee?a. Iae/ano?oei caoaeieeii ? Candida albicans -o 55,3 a?aenioe?a ae?iie. Cono??/athoueny oaeiae ?io? aeaee eaiaeeae: Candida intermedia (22,3%), Candida krusei (11,2%) oa Candida viswanathii (11,2%). 5. Aeey ee?i?/ii? ea?oeie naenoaeueii? aeenooieoe?? ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie oeiiaith ? a?iinaenoaeuei?noue, aea aiia ia? a?aeiiniee oa?aeoa?. ?iceaaee naenoaeueii? ooieoe?? o iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie coiiaeai? aieeaii nioe?aeueieo, ineoieia?/ieo oa nioe?aeueii-ineoieia?/ieo /eiiee?a ia oe? ai?iiiaeueieo oa ?ioiieia?/ieo ii?ooaiue, ui iia’ycaii c iniiaiith iaoieia??th ae?iie . 6. Aeei?enoaiiy a eiiieaeni?e oa?ai?? ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, ii?yae c ai?iiiaeueieie oa i?ioecaiaeueieie i?aia?aoaie, AEIE oa i?iaoooeeio aeicaiey? nooo?ai cieceoe ee?i?/i? i?iyae caoai?thaaiiy, ni?ey? ii?iae?caoe?? aiaeie?eiii? ooieoe?? a?iio?ca, y?/iee?a, iieaciee?a i?noeaaiai ?ioi?oaoo, a?ioeaiico i?oae, i?aeaeuaiith ineoinioeiaeueii? aaeaioaoe?? iiae?oaei?o ia? oa a?aeiiaeaiith naenoaeueii? ooieoe?? ae?iie. I?AEOE*II ?AEIIAIAeAOeI? 1. Iayai?noue a aiaiiac? o?ii?/ieo caiaeueieo i?ioean?a a i?eaeaoeao oa iaooe?, i?neyaai?oieo oa i?neyiieiaiaeo oneeaaeiaiue oa caiaeueieo oneeaaeiaiue aioo??oiueiiaoeiai? eiio?aoeaioe?? iiaeooue na?ae/eoe i?i ?o ii?aeiaiiy c aai?oaeueiei aiaeiiao??icii. 2. Iniaeeainoyie ee?i?/iiai ia?aa?ao aai?oaeueiiai aiaeiiao??ico, iiaaeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie, ? a?eueo o?eaaeee ia?aa?a iaio caoai?thaaiue, aaia?ae?caoe?y aieth, noeeuei?noue aei ?aoeeaeeaoaaiiy, ii?ooaiiy i?e?iaeiiai a?ioeaiico i?oae, iecueea aoaeoeai?noue aacenii? oa?ai??, ui iiaea aooe aeei?enoaii a yeino? e?eoa???a aeeoa?aioe?aeueii? ae?aaiinoeee oeueiai caoai?thaaiiy. 3. Aei caaaeueiii?eeiyoiai ieaio ianoaaeaiiy iaoe??ioie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie ne?ae aeeth/aoe iaoiaeeee aea/aiiy noaio i?noeaaiai ?ioi?oaoo (aecia/aiiy ?ioiiaeiaoe?i?a A, SA, G oa M a oea?a?eaeueiiio neec?) oa ae?aaiinoeeo a?eaeiaiai ian?iai?iiy noaoaaeo oeyo?a. 4. Eiiieaen e?eoaaeueieo caoiae?a o oaeeo ae?iie iiaeiai aeeth/aoe ?acii c i?ioecaiaeueiith, ?icniieooth/ith, aioeno?ani?iith, ai?iiiaeueiith oa?ai??th canoinoaaiiy a yeino? nenoaiii? ?ioiiei?aeoe?? eaca?io oa?ai?th (AEIE) oa i?aia?aoe aeey ii?iae?caoe?? a?ioeaiico i?oae, cie?aia i?iaoooeei. Aaa?iaeuei? noiiceoi??? i?iaoooeeio, eiaeia c yeeo i?noeoue 100 mg iaoai?oeeio i?ecia/athoue ii iaei?e ia i?/ oi?iaeiaae 3 aai 6 aei?a, caeaaeii a?ae nooiaiy oyaeeino? oa o?eaaeino? ee?i?/ieo iciae eaiaeeaeico noaoaaeo oeyo?a. I?e iaaeinoaoi?e aoaeoeaiino? aaa?iaeueieo noiiceoi???a i?iaoooeeio i?ecia/athoue oaaeaoee i?iaoooeeia per os ii 1 oaaeaooe? (100 ia.) 4 ?ace ca aeiao ai?iaeiaae 10 aei?a. Iaeii/anii a iaiayceiaiio ii?yaeeo i?iaiaeyoue naiaoe?th noaoaaiai ia?oia?a. Aioo??oiueinoaeeiia eaca?ia ii?ii?ithaaiiy e?ia? (AEIE), i?iaiaeyoue aae?e - iaiiiaei eaca?ii EAI- (c i?oei?noth ii?ii?iaiiy ia aeoiae? ?c na?oeiaiaea 1,5 iAo). O?eaae?noue i?ioeaaeo?e caeaaeeoue a?ae noaio iaoe??ioee ? i?iaeiaaeo?oueny 20 - 40 oaeeei. E?euee?noue i?ioeaaeo? eieeaa?oueny a?ae 5 aei 10. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1.Ae?aaiinoeea ? e?eoaaiiy eaiaeeaeico i?e ii?aeiaieo oi?iao aaiioaeueiiai aiaeiiao?iico // Iaae?ao??y, aeooa?noai oa a?iaeieia?y . - 1995. - ? 3. - N. 45 - 47. (ni?aaao. I.O. Ieoaeeaiei, I.O. Eaueinueeee, A.A. Oeeieoi ). 2.Canoinoaaiiy i?iaoooeeio o oai?eo ia aai?oaeueiee aiaeiiao??ic a ii?aeiaii? c o?ii?/iei caiaeueiei i?ioeanii // E?ee. - 1997. - ? 6. - N. 76 - 78 (ni?aaao. A. A. Oeeieoi). 3.Oa?aeoa?enoeea i?noeaaiai ?ioi?oaoo i?e aiaeiiao??ic? aai?oae?e a ii?aeiaii? c o?ii?/iei caiaeueiei i?ioeanii // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. - 1997. - ? 6. - N. 92 - 93. 4.No/ania oyaeaiiy i?i aiaeiiao??ic // Ca??iee iaoeiaeo noaoae a/aieo Eoaainueeiai Aea?aeaaiiai iaaee/iiai oi?aa?neoaoo "Iaaeeei- a?ieia?/i? i?iaeaie i?iieneiaiai ?aa?iio". - Eoaainuee, 1997. - N. 173-178. 5.Iniaaiiinoe aaaeaiey aieueiuo n aaieoaeueiui aiaeiiao?eicii a ni/aoaiee n aaeiaeneoii // Oacenu aeieeaaeia iao/ii ia?aeoe/aneie eiioa?aioeee aeooa?ia - aeiaeieiaia. - Aeiiaoee, 1993. - N. 45. (niaao.: E.Ae. Ai?iaaineay, A.I. Iaoeiaa ). 6.Aioo??oiueinoaeeiiee aae?e-iaiiiaee eaca? o e?eoaaii? aai?oaeueiiai aiaeiiao??ico a ii?aeiaii? c o?ii?/ieie caiaeueieie caoai?thaaiiyie aai?oae?e // Ai?eii - caiaethaaeuei? i?ioeane a no/ani?e aeooa?nueei - a?iaeieia?/i?e i?aeoeoe? : Oace ieaioio i?aae?iiy aeooa??a - a?iaeieia?a Oe?a?ie. - Caii??aeaey, 1995. - N. 105 - 106. (ni?aaao. I.O. Eaueinueeee, A.A. Ieoe?i). 7.Noai naenoaeueiiai caei?ia’y iiae?oaei?o ia? c aiaeiiao??icii ae?oaeeie a ii?aeiaii? c caiaeueieie i?ioeanaie aai?oae?e / O c’?cae aeooa??a- a?iaeieia?a Oe?a?ie: Oace ?ia?o, 1996. - N. 141. AIIOAOe?ss Ieoe?ia E. A. Ae?aaiinoeea, ee?i?ea oa e?eoaaiiy aaiioaeueiiai aiaeiiao?iico, ii?aeiaiiai c o?ii?/ieie caiaeueieie i?ioeanaie. -?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 - aeooa?noai oa a?iaeieia?y. - ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? Aeaaeai?? iaaee/ieo iaoe Oe?a?ie. - Ee?a, 1998. Caoeua?oueny ?oeiien eaiaeeaeaonueei? aeena?oaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 7 i?aoeue. Ia i?aenoaa? ii??aiyeueiiai aea/aiiy ai?iiiaeueiiai aiiainoaco, i?noeaaiai ?ioi?oaoo, aaa?iaeueiiai a?ioeaiico ee?i?/ii e iaoeiai iaa?oioiaaia iaiao?aei?noue ei?aeoe?? i?noeaaiai ?ioi?oaoo oa naiaoe?? o?ii?/ieo i/aa?a eaiaeeaeico. Aeei?enoaiiy a eiiieaeni?e oa?ai?? ae?iie c aai?oaeueiei aiaeiiao??icii, ii?aeiaiei c o?ii?/ieie caiaeueieie i?ioeanaie, ii?yae c ai?iiiaeueieie oa i?ioecaiaeueieie i?aia?aoaie, AEIE oa i?iaoooeeio aeicaiey? nooo?ai cieceoe ee?i?/i? i?iyae caoai?thaaiiy, ni?ey? ii?iae?caoe?? aiaeie?eiii? ooieoe?? a?iio?ca, y?/iee?a, iieaciee?a i?noeaaiai ?ioi?oaoo, a?ioeaiico i?oae, i?aeaeuaiith ineoinioe?aeueii? aaeaioaoe?? iiae?oaei?o ia? oa a?aeiiaeaiith naenoaeueii? ooieoe?? ae?iie. Eeth/ia? neiaa: aai?oaeueiee aiaeiiao??ic, o?ii?/i? caiaeuei? i?ioeane, eaiaeeaeic, i?noeaaee ?ioi?oao, AEIE, i?iaoooeei. AIIIOAOeEss Iuoeeia E. A. Aeeaaiinoeea, eeeieea e ea/aiea aaieoaeueiiai yiaeiiao?eica, ni/aoathuaainy n o?iie/aneeie ainiaeeoaeueiuie i?ioeannaie. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01. - aeooa?noai e aeiaeieiaey. - Einoeooo iaaeeao?ee, aeooa?noaa e aeiaeieiaee Aeaaeaiee iaaeeoeeineeo iaoe Oe?aeiu. - Eeaa, 1998. Caueuaaony ?oeiienue eaiaeeaeaoneie aeena?oaoeee. Ii oaia aeena?oaoeee iioaeeeiaaii 7 ?aaio. Ia iniiaa n?aaieoaeueiiai eco/aiey ai?iiiaeueiiai aiiainoaca, ianoiiai eiioieoaoa, aaaeiaeueiiai aeioeaiica eeeie/anee e iao/ii iainiiaaiu iaiaoiaeeiinoue ei??aeoeee ianoiiai eiioieoaoa e naiaoeee o?iie/aneeo i/aaia eaiaeeaeica. Eniieueciaaiea a eiiieaeniie oa?aiee aeaiuei n aaieoaeueiui yiaeiiao?eicii, ni/aoathueiny n o?iie/aneeie ainiaeeoaeueiuie i?ioeannaie, ia?yaeo n ai?iiiaeueiuie e i?ioeaiainiaeeoaeueiuie i?aia?aoaie, AEIE e ieiaoooeeia, iicaieyao nouanoaaiii nieceoue eeeie/aneea i?iyaeaiey caaieaaaiey, niinianoaoao ii?iaeecaoeee yiaeie?eiiie ooieoeee aeiioeca, ye/ieeia, iieacaoaeae ianoiiai eiioieoaoa, aeioeaiica aeaaaeeua, iiauoaieth ineoiyiioeeiiaeueiie aaeaioaoeee naiaeiuo ia? e ainnoaiiaeaieth naenoaeueiie ooieoeee aeaiuei. Eeth/aaua neiaa: aaieoaeueiue yiaeiiao?eic, o?iie/aneea ainiaeeoaeueiua i?ioeannu, eaiaeeaeic, ianoiue eiioieoao, AEIE, ieiaoooeei. SUMMARY Pichkina L. V. The diagnosis, clinical picture and treatment of genital endometriosis in combination with chronic inflammation. Manuscript of the thesis for a candidate’s degree in medicine in speciality 14.00.01.- obstetrics and gynaecology.- Academy of Medical Sciences, Institute of Paediatrics, Obstetrics and Gynaecology. Ukraine, Kiev, 1998. The manuscript of the thesis is defended. Seven printed articles have been published on the topic of the thesis. On the basis of comparative investigation of hormonal homeostasis, vaginal biocenosis the author scientifically and practically proves the necessity to correct local immunity and to cure chronic foci of candidiasis. The use in complex treatment of women suffering from genital endometriosis in combination with chronic inflammation of hormonal and anti-inflammatory preparation, intravascular laser blood irradiation and pimafucini gives the possibility to abate clinical picture and to normalise the endocrine functions of hypophysis, ovarium, local immunity and biocenosis of groin and to improve psycological and social adaptation of married couples and to renew sexual functions of women. Key words: genital endometriosis, chronic inflammation, candidiasis, local immunity; intravascular laser blood irradiation, pimafucini.

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