EE?ANUeEEE IAOEIAI — AeINE?AeIEE ?INOEOOO

AAIAOIEIA?? OA IA?AEEAAIIss E?IA?

IIC OE?A?IE

Oeeiaaethe — Aieioei

??eia Iao??aia

OAeE 616.155.392.8+616.155.392-036.11:612.014.1+616-091.8

Ae?AAIINOE*IA OA I?IAIINOE*IA CIA*AIIss

OeEOIO?I?*IIAI OA ?IOIIEIA?*IIAI

OAIIOEIOAAIIss AEANOIEO EE?OEI O OAI?EO

AINO?ITH I??EI?AeIITH EAEEAI??TH

14.01.31 — aaiaoieia?y oa o?ainooc?ieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Euea?anueeiio o?e?ae? Ee?anueeiai iaoeiai-aeine?aeiiai
?inoeoooo aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a?ie.

Iaoeia? ea??aieee: — aeieoi? iaaee/ieo iaoe, i?ioani?

Eia?inueeee Aieiaeeie? Inoaiiae/,

caa?aeoaa/ eaai?aoi??? ?ioiieia?? Euea?anueeiai o?e?aeo Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo aaiaoieia?? oa ia?aeeaaiiy e?ia? IIC
Oe?a?ie

— aeieoi? iaaee/ieo iaoe, i?ioani?

Aeaianueea ss?ineaaa ?ee?aia,

caa?aeoaa/ a?aeae?eaiiy aaiaoieia?? Euea?anueeiai o?e?aeo
Ee?anueeiai iaoeiai-aeine?aeiiai ?inoeoooo aaiaoieia??

oa ia?aeeaaiiy e?ia? IIC Oe?a?ie

Io?oe?ei? iiiiaioe: — aeieoi? iaaee/ieo iaoe, i?ioani?

?iiaiiaa Aeea Oaaei??aia,

i?ia?aeiee iaoeiaee ni?a?ia?oiee a?aeae?eo aaiaoieia?? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo aaiaoieia?? oa o?ainooc?ieia??

— aeieoi? iaaee/ieo iaoe, i?ioani?

Aeociai Aeaie?e O?oaeaae/,

caa?aeoaa/ a?aeae?eii ?ioiioeeoio?i?? ?inoeoooo aenia?eiaioaeueii?
iaoieia??, iieieia?? oa ?aae?ia?ieia?? ?i. ?.?. Eaaaoeueeiai

IAI Oe?a?ie

I?ia?aeia onoaiiaa: — Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?
ina?oe IIC Oe?a?ie, eaoaae?a aaiaoieia?? oa o?ainooc?ieia??

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 11 ” eenoiiaaea 1998 ?. i
13 aiae. 00 oa.

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.612.01 a Ee?anueeiio
IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia? (254060, i. Ee?a, aoe. I.
Aa?e?inueeiai, 12).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Ee?anueeiai IAe?
aaiaoieia?? oa ia?aeeaaiiy e?ia? (i. Ee?a, aoe. I. Aa?e?inueeiai, 12).

Aaoi?aoa?ao ?ic?neaiee “ 1 ” aeiaoiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee EII?NA?AIEI A. A.
Aeooaeuei?noue oaie. Aino?a i??ei?aeia eaeeai?y (AIE) caeia? /?eueia
i?noea na?aae ?ioeo oi?i aino?i? eaeeai?? o aei?ineeo. Ca inoaii? ?iee
eiinoaoiaaii iii?oiee ??no caoai?thaaiino? oe??th oi?iith aaiiaeanoic?a.
A?aeiii, ui ii??aiyii c aino?ith e?ioiaeanoiith eaeeai??th, AIE
ae??ciy?oueny a?eueo iani?eyoeeaei i?iaiicii. AIE oa?aeoa?eco?oueny
cia/iith aaoa?iaaii?noth iooeeiii? i?ie?oa?aoe?? ??cieo e?i?e
i??eiiiaco, cie?aia, a?aioeioeeoa?ii-iae?ioaaaeueii?,
iaaaea??ioeeoa?-ii?, a?eo?ioeeoa?ii?, ui iiaea aooe /anoeiaei iiyniaiiyi
??cii? aoaeoeaiino? canoiniaoaaii? oa?ai??, o?eaaeino? ?ai?n?? oa aeeooy
oai?eo. Aei oaia? ia ? inoaoi/ii ae??oaiei ieoaiiy eeaneo?eaoe?? AIE,
aeineiiaei? o oai?aoe/iiio a?aeiioaii? oa ?aoe?iiaeueii? a ee?i?/iiio
ieai?. Aaccaia?a/iei ? iieiaeaiiy, ui a iniia? oaei? eeaneo?eaoe??
iiaeiii aooe aecia/aiiy e?i?eiiai iioiaeaeaiiy oa ??aiy c??eino? ee?oei
iooeeiiiai eeiio. I?ioa i?aeoiaee iaoeiaoe?a aei ae??oaiiy oeueiai
caaaeaiiy ? iaaecae/aeii ??cieie. Oae, ?yae aeine?aeiee?a aaaaea?
aecia/aeueieie ii?oieiai- oeeoio?i?/i? iciaee aeanoieo ee?oei, ye?
ia?aaeaa/a? FAB- eeaneo?eaoe?y [D. R. Head ? ni?aaao., 1985; G.
Flandrin, 1986], ?io? a?aeaeathoue ia?aaaao ?ioiioaiioei?/iei
iniaeeainoyi aeano?a i?e AIE [I. E. Aaia ? ni?aaao., 1996], iniaeeai o
aeiaaeeao noii?aii? /e a?ae’?iii? oeeoio?i?/ii? aeoeaiino? eaeeai?/ieo
ee?oei [P .B. Neam ? ni?aaao., 1986; C. A. Hanson ? ni?aaao., 1987].
Aaaaoi aeine?aeiee?a a?aenoiththoue iiceoe?th eiiieaenii? ioe?iee
ii?oieiai-oeeoio?i?/ieo oa ?ioiieia?/ieo aeanoeainoae aeano?a [E.
Matutes ? ni?aaao., 1988; L. Vainkus ? ni?aaao., 1991]. Aaoi?e ae I?N-
eeaneo?eaoe??, ii?yae c ii?oieia?/ieie oa ?ioiieia?/ieie, aaiaeyoue
oeeoiaaiaoe/i? e?eoa??? iiae?eo AIE [H. Van den Berghe, 1988]. Ia ?o
ae?aaiinoe/ia oa i?iaiinoe/ia cia/aiiy aeaco? ? U. Creutzig ? ni?aaao.
[1995].

Iii?e ?nioaaiiy oaeiai ?icia?ooy iaoeiaeo aeoiie, ia nueiaiaei?oi?e
aeaiue iaea?eueo oe?iei aeei?enoiao?oueny ii?oieiai-oeeoio?i?/ia FAB-
eeaneo?eaoe?y AIE, ui coiiaeaii ?? a?aeiiniith i?inoioith,
iaoiaeieia?/iith aeinooii?noth, i?iaiinoe/iith aa?o?noth. I?ioa, ne?ae
a?aoiaoaaoe ? aeaui iecueeo ?? a?aeoai?thaai?noue [M. Gonsales ?
ni?aaao., 1987; G. L. Castoldi ? ni?aaao., 1993; M. Rigolin ? ni?aaao.,
1995] oa ?nioaaiiy iaae? ?? aeeoa?aioe?eieo iiaeeeainoae [K. Janicki,
1992]. Naia inoaii?e oaeoi? coiiaeth? oa, ui iaaiee a?aenioie aeiaaee?a
aino?i? eaeeai?? caeeoa?oueny ianeeaneo?eiaaiei.

Oaeei /eiii, iiooee iioeiaeueieo aeeoa?aioe?eii-ae?aaiinoe/ieo oa
i?iaiinoe/ii aa?o?nieo e?eoa???a iiae?eo AIE ? iaa?oioiaaieie,
aeooaeueieie oa ia?niaeoeaieie ye a oai?aoe/iiio, oae ? a i?aeoe/iiio
?aeo?n?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?? iia’ycaia c aeeiiaiiyi o Euea?anueeiio o?e?ae? Ee?anueeiai
IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia? IAe? “Aea/aiiy
aeeoa?aioe?eii-ae?aaiinoe/iiai oa i?iaiinoe/iiai cia/aiiy oeeoio?i?/iiai
oa ?ioiieia?/iiai oaiioeioaaiiy eaeeai?/ieo ee?oei o oai?eo
iaaeeoa?aioe?eiaaiith oa aino?ith i??ei?aeiith eaeeai??th, aeae?eaiiy
?ioiiii?oieia?/ieo aa??aio?a caoai?thaaiiy c iaoith aecia/aiiy iaea?eueo
aoaeoeaieo noai oeeoinoaoe/ii? oa?ai??“, ? Aea?aeaaii? ?a?no?aoe?? UA
01000 145 P oa IAe? “?ic?iaeoe oeeoiii?oieia?/i?, ?ioiieia?/i? oa
oeeoiaaiaoe/i? e?eoa??? ae?aaiinoeee, i?iaiicoaaiiy ia?aa?ao, aeai?o
e?eoaaeueii? oaeoeee i?e i??eiaeenieanoe/iiio neiae?ii? oa ceiye?nieo
i??eii?ie?oa?aoeaieo caoai?thaaiiyo…“, ? Aea?aeaaii? ?a?no?aoe??
01.95. UA 28286.

Iaoa ? caaaeaiiy aeine?aeaeaiiy. Iaoa aeaiiai aeine?aeaeaiiy —
aeynieoe cia/aiiy ii?oieia?/ieo, oeeoio?i?/ieo oa ?ioiioaiioei?/ieo
iciae aeanoieo ee?oei aeey ae?aaiinoeee i?aeaa??aio?a AIE oa
i?iaiicoaaiiy ia?aa?ao caoai?thaaiiy.

Aeey aeinyaiaiiy oe??? iaoe aoee iinoaaeai? ianooii? caaaeaiiy:

1. Aea/eoe ii?oieia?/i?, oeeoio?i?/i? oa ?ioiieia?/i? aeanoeaino?
eaeeai?/ieo ee?oei i?e AIE.

2. Aeae?eeoe ii?oieiai-oeeoio?i?/i? i?aeaa??aioe oa ?ioiieia?/i?
i?aea?oie AIE, ni?anoaaeoe ?acoeueoaoe ii?oieiai-oeeoio?i?/iiai oa
?ioiieia?/iiai oaiioeioaai-iy aeanoieo ee?oei.

3. Aeine?aeeoe iniaeeaino? ia?aa?ao aeae?eaieo i?aeaa??aio?a oa i?aea?oi
AIE.

4. Aeynieoe cia/aiiy ?ioiieia?/iiai oaiioeioaaiiy aeanoieo ee?oei aeey
i?iaii-coaaiiy ia?aa?ao AIE.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aaeineiiaeaii oeeoio?i?/i?
e?eoa??? aeeoa?aioe?aoe?? FAB- i?aeaa??aio?a AIE (I1-I2 ? I4-I5).
Iaa?oioiaaii eiioeaioe?th, ui ?ioiieia?/i? ia?ea?e aeeoa?aioe?aoe??
aeano?a i?e AIE c’yaeythoueny ?ai?oa, i?ae ii?oieiai-oeeoio?i?/i? iciaee
iai?yio ? nooiaiy ?o aeic??aaiiy. Noeoii?noue ?ioiioaiioei?/ieo iciae
ee?oeie a?eueo oi/ii oa?aeoa?eco? ?? e?i?eia iioiaeaeaiiy ii??aiyii c
ii?oieiai-oeeoio?i?/ieie iniaeeainoyie. Ia oe?e iniia? ?ic?iaeaii
i?eioeeie ?ioiieia?/ii? eeaneo?eaoe?? AIE, aeae?eaii ?ioiieia?/i?
i?aea?oie AIE oa aino?o a?a?eaeio eaeeai?th. Aecia/aii ni?aa?aeiioaiiy
i?ae ii?oieiai-oeeoio?i?/ieie (FAB) i?aeaa??aioaie oa ?ioiieia?/ieie
i?aea?oiaie i?e AIE. Anoaiiaeaii oa?aeoa? ? i?e/eie ?ica?aeiinoae i?ae
ii?oieiai-oeeoio?i?/iith oa ?ioiieia?/iith oa?aeoa?enoeeith aeano?a o
/anoei? aeiaaee?a AIE. I?iaaaeaii ioe?ieo ee?i?/iiai ? i?iaiinoe/iiai
cia/aiiy ia?ea?ii? oa?aeoa?enoeee aeanoieo ee?oei i?e AIE.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Anoaiiaeaii cia/aiiy
canoinoaaiiy ye?nii? oa iai?ae?euee?nii? ioe?iee oeeoio?i?/ii?
aeoeaiino? i??eiia?ieneaeace a aeanoieo ee?oeiao i?e AIE aeey aecia/aiiy
?o e?i?eii? iaeaaeiino? (“i??ei?aeiee“ oa “iiiioeeoa?iee“ oei
?iciiae?eo) oa nooiaiy c??eino?, a oaeiae oeeoio?i?/ii? aeoeaiino?
oei?aoeaoaoanoa?ace aeey aeeoa?aioe?eii? ae?aaiinoeee I1/I2 oa I4/I5
i?aeaa??aio?a AIE. Iieacaii oe?ii?noue canoinoaaiiy iaiae?
iiiieeiiaeueieo aioeo?e (IEAO) aeey ae?aaiinoeee oa aeae?eaiiy
?ioiieia?/ieo i?aea?oi AIE, a oaeiae ae?aaiinoeee aino?i? a?a?eaeii?
eaeeai??. Aecia/aii i?iaiinoe/ia cia/aiiy ?ioiieia?/iiai oaiioeioaaiiy
i?e AIE.

?acoeueoaoe aeine?aeaeaiue iieeaaeaii a iniiao ?ioi?iaoe?eiiai eenoa
“Ae?aaiinooaaiiy i?aeaa??aio?a aino?i? eaeeai?? a?aeiia?aeii aei FAB-
eeaneo?eaoe?? ca aeiiiiiaith oeeoio?i?/ieo ?aaeoe?e“ (Ee?a, 1993).
Iniiai? iieiaeaiiy aeena?oaoe?? ai?iaaaeaeai? a i?aeoeeo aaiaoieia?/iiai
a?aeae?eaiiy 5-i? ee?i?/ii? e?ea?i? i. Eueaiaa, eiinoeueoaoeaii?
iie?ee?i?ee Euea?anueeiai o?e?aeo Ee?anueeiai IAe? aaiaoieia?? oa
ia?aeeaaiiy e?ia?, aaiaoieia?/iiai eaa?iaoo eiinoeueoaoeaii? iie?ee?i?ee
Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, aeeoy/iai aaiaoieia?/iiai
a?aeae?eaiiy Euea?anueei? iaeanii? aeeoy/i? niaoe?ae?ciaaii? ee?i?/ii?
e?ea?i?.

Iniaenoee aianie caeiaoaa/a. Iniaenoee aianie aaoi?a iieyaaa a aiae?c?
aeooaeueiino? ? nooiaiy aea/aiiy oaie ?iaioe, aeai?? ? ii?aoethaaii?
iaoiaeee aeine?aeaeaiiy, i?iaaaeaii? ii?oieia?/ieo, oeeoio?i?/ieo oa
?ioiioaiioei?/ieo aeine?aeaeaiue aeanoieo ee?oei e?ia? oa e?noeiaiai
iiceo, ia?iaoe? iaoa??aeo. Aeyaeai? caeiiii??iino? noi?ioeueiaaii o
aeniiaeao. Aeine?aeaeaiiy ?ioiioaiioeio aeanoieo ee?oei e?ia? oa
e?noeiaiai iiceo aeeiiaii ni?eueii c i?ia. iaoe. ni?a?., e.i.i. C.A.
Ianeye.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ?iaioe
aeiiia?aeaeenue ia O??? c’?cae? I?aeia?iaeiiai oiaa?enoaa aaiaoieia?a
(?a?iiaenueea oa Ao?eeainueea a?aeae?eaiiy) (Noaiaoe, 1995), ???
Oe?a?inueeiio c’?cae? aaiaoieia?a oa o?ainooc?ieia?a (Noie, 1995),
can?aeaii? iaaee/ii? naeoe?? Iaoeiaiai oiaa?enoaa ?i. O. Oaa/aiea
(Euea?a, 1997), iaoeia?e eiioa?aioe??, i?enay/ai?e 10-??//th
aaiaoieia?/iiai a?aeae?eo ?inoeoooo ee?i?/ii? ?aae?ieia?? IOe?I AII
Oe?a?ie (Ee?a, 1997).

Ioae?eaoe??. Ia oaio aeena?oaoe?? iioae?eiaaii 7 ?ia?o, a o. /. 4
iaoeia? noaoo?. Aeaeaii ?ioi?iaoe?eiee eeno.

IANssA OA NO?OEOO?A AeENA?OAOe??

Aeena?oaoe?th aeeeaaeaii ia 154 noi??ieao iaoeiiieno, c ieo 134
noi??iee oaenoo, 8 noi??iie caeiathoue ?ethno?aoe??, 12 — oaaeeoe?, 20 —
ia?ae?e aeei?enoaii? e?oa?aoo?e. Aeena?oaoe?y neeaaea?oueny c? anooio,
iaeyaeo e?oa?aoo?e, naie ?icae?e?a aeanieo aeine?aeaeaiue, aiae?co oa
ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy, aeniiae?a oa i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo aeei?enoaii? e?oa?aoo?e. Nienie e?oa?aoo?e
aeeth/a? 172 aeaea?aea. ?iaioo ?ethno?othoue 32 oaaeeoe? oa 8 ?enoie?a.

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy.

Aeine?aeaeaiiy ee?oei e?noeiaiai iiceo ?/aai ia?eoa?e/ii? e?ia?
i?iaaaeaii o 81 oai?iai AIE, ia?aaaaeii aia?oa aeyaeaiith. Ae?aaiic
aino?i? eaeeai?? anoaiiaethaaee ia i?aenoaa? ee?i?/ii? ea?oeie, aeaieo
aiae?co ia?eoa?e/ii? e?ia?, oeeoieia?/iiai aeine?aeaeaiiy noa?iaeueiiai
ioieoaoo (a?aenioie aeano?a > 30 % on?o iaa?eo?i?aeieo ee?oei). Aeey
oeioaaiiy oeeoiii?oieia?/iiai i?aeaa??aioo AIE ca e?eoa??yie FAB-
eeaneo?eaoe?? i?iaiaeeeenue ianooii? oeeoio?i?/i? ?aaeoe??: ia
i??eiia?ieneaeaco (I?I) iaoiaeii Loeele (1936), ia e?i?aee iaoiaeii
caaa?aeaiiy noaeaiii /i?iei A ca Ackerman (1952), ia iie?naoa?eaee ca
aeiiiiiaith PAS- ?aaeoe?? ca McManus (1946), ia ianiaoeeo?/io anoa?aco c
?ia?a?oi?ii NaF iaoiaeii aciniieo/aiiy (1960), ia oei?aoeaoaoanoa?aco
iaoiaeii aciniieo/aiiy (1960).

?ioiieia?/ia oaiioeioaaiiy aeanoieo ee?oei aeeiioaaeinue iai?yiei
?ioiioethi?anoeaioiei iaoiaeii a iiiioa?? ee?oei, i?ee??ieaieo aei neea
ca aeiiiiiaith iie?-L-e?ceio (Sigma). sse aoi?eii? aioeo?ea
aeei?enoiaoaaeenue F(ab)2 — o?aaiaioe aioeo?e aei ?ioiiaeiaoe?i?a a?ei?
ieo?, iii?/ai? oethi?anoea?i?cio?ioe?aiaoii (O?OOe), ae?iaieoeoaa IAI
“I?aia?ao“ i?e Ieaeiuei — Iiaai?iaenueeiio IAe? A?I. A?aenioie
aioeaaiiiceoeaieo ee?oei i?ae?aoiaoaaany ia 100 — 200 iiiiioeeaa??a,
ei?enooth/enue ethi?ianoeaioiei i?e?ineiiii “Ethiai ? — 8“. Iaiaeue
iiiieeiiaeueieo aioeo?e aeeth/aea iaieaeeioeeoa?ia IEAO, IEAO aei
ia?ea??a ee?oei-iiia?aaeiee?a aaiiiiaco, aei iaii??ei?aeieo,
i??ei-iiiioeeoa?ieo, iiiioeeoa?ieo ia?ea??a, IEAO aei aeano?a aino?i?
i??eiiiiioeeoa?ii? eaeeai??, IEAO aei aioeaaio a?eo?iaeano?a, anueiai 21
aeae. Aeni?an?th ia?ea?a ia aeanoieo ee?oeiao aaaaeaee iiceoeaiith, eiee
eiai aeni?an?y aoea aeyaeaia ia > 20 % ee?oei. Aeiaaeee c ??aiai
aeni?an?? F 20 % ?icaeyaeaeeny ye iaaaoeai?. Aiae?c ?acoeueoao?a
oaiioeioaaiiy i?iaiaeeee aeaiia niiniaaie, a naia: ioe?ithth/e ??aaiue
aeni?an?? ia?ea??a ca /ioe?eaaeueiith oeaeith oa ca na?aaeiueith
e?euee?noth ee?oei, ye? aeni?anoaaee aeaiee aioeaai a iaaaoeaieo ?
iiceoeaieo aeiaaeeao.

?acoeueoaoe aeine?aeaeaiue aiae?coaaeeny iaoiaeii aa??aoe?eii?
noaoenoeee c aeei?enoaiiyi e?eoa??y Nothaeaioa — O?oa?a aeey
ia?aiao?e/ieo aaee/ei. I?e ii??aiyii? /anoioieo aaee/ei canoiniaoaaee
oi?ioeo O?oa?a (A. TH. O?aao, 1963). On? iaaaaeai? a aaoi?aoa?ao?
caeaaeiino?, aeey yeeo ia aeacaii aaee/eie aeinoia??iino? p,
caaeia?eueiythoue aeiiao p < 0,05. ?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss Ca?aeii c FAB- eeaneo?eaoe??th na?aae ianoaaeaieo oai?eo aoei aeae?eaii ianooii? i?aeaa??aioe AIE: I0 - aino?a i?i?iaeueii aeeoa?aioe?eiaaia i??ei?aeia eaeeai?y - 3 oai?eo (3.7 %); I1 - aino?a i??eiaeanoia eaeeai?y aac iciae aeic??aaiiy - 26 oai?eo (32.2 %); I2 - aino?a i??eiaeanoia eaeeai?y c iciaeaie aeic??aaiiy - 24 oai?eo (29.6%); I4 - aino?a i??eiiiiioeeoa?ia eaeeai?y - 13 oai?eo (16.0 %); I5 - aino?a iiiioeeoa?ia eaeeai?y - 8 oai?eo (9.9 %), c ieo I5a - 5 in?a, I5b - 3 iniae; I6 - aino?a a?eo?ieaeeai?y - 7 oai?eo (8.6 %). Ia iniia? ii?oieiai-oeeoio?i?/ieo e?eoa???a ia aoei aeyaeaii aino?i? i?ii??eioeeoa?i? eaeeai?? (I3) oa aino?i? iaaaea??ioeeoa?ii? eaeeai?? (I7). Aea/aiiy aeoeaiino? i??eiia?ieneaeace aeeth/aei i?ae?aooiie a?aenioea ia?ieneaeaciiiceoeaieo ee?oei, ioe?ieo ?ioaineaiino? ?aaeoe?? (4 nooiai? aeoeaiino?), oa?aeoa? ?? ?iciiae?eo a ee?oei? (“i??ei?aeiee“ - aieiaii oeeoiieaciaoe/ia ?icoaooaaiiy a?aioe, ca?oiiaaieo ia?aaaaeii a ia?eioeeaa?i?e cii?, oa “iiiioeeoa?iee“ - a?aioee ??aiii??ii ?icn?yi? a oeeoiieaci? oa iaae yae?ii ee?oeie). Aeyaeaii, ui I1 oa I2 i?aeaa??aioe AIE noaoenoe/ii aeinoia??ii ??ciyoueny nooiaiai aeoeaiino? I?I (i?e I1 ia?aaaaea? 1-e nooi?iue aeoeaiino?, i?e I2 - 2-e nooi?iue), a i??eiaeanoi? (I1 ? I2) oa iiiioeeoa?i? (I4 ? I5) - oa?aeoa?ii ?iciiae?eo i?iaeoeoo ?aaeoe?? (“i??ei?aeiee“ oei aeanoeaee aeey I1 oa I2; “iiiioeeoa?iee“ - aeey I4 oa I5). Oaeei /eiii, nooi?iue aeoeaiino? I?I aeicaiey? aeeoa?aioe?thaaoe I1 ? I2 i?aeaa??aioe AIE, a aecia/aiiy oa?aeoa?o ?iciiae?eo i?iaeoeo?a ?aaeoe?? ia III i?eaeaoia aeey ?ici?ciaaaiiy iiiioeeoa?ieo i?aeaa??aio?a (I4 ? I5) a?ae i??eiaeanoieo (I1 ? I2). I?e aeine?aeaeaii? aeoeaiino? oei?aoeaoaoanoa?ace (NAA) aeyaeaii, ui I1 i?aeaa??aio oa?aeoa?eco?oueny ia?aaaaeii iecueeith aeoeai?noth NAA o aeanoao, I2 oa I4 - iii??iith; o aeanoieo ee?oeiao i?e I5 ?aaeoe?y ia NAA a?ae’?iia. Ioiae, aeaiee oano iiaea neoaoaaoe aeiaeaoeiaei e?eoa???i aeey aeeoa?aioe?aoe?? I1 ? I2 i?aeaa??aio?a, a oaeiae aeey ?ic??ciaiiy I4 ? I5 i?aeaa??aio?a AIE. ?ioiioaiioeioaaiiy aeanoieo ee?oei e?ia? oa e?noeiaiai iiceo ca aeiiiiiaith iaiae? IEAO i?iaaaeaii o 40 oai?eo AIE. Iaiaeue IEAO aoea i?ae?a?aia oaeei /eiii, uia iiaeia aoei ioa?aeoa?ecoaaoe ??ci? e?i?? oa noaae?? i??eiiiaco ? ni?aa?aeianoe c ieie oaiioei?/i? iciaee aeanoieo ee?oei a ianoaaeaieo oai?eo AIE. ?acoeueoaoe aeine?aeaeaiue iieacaii a oaae.1. Iaieaeeioeeoa?iee aioeaai CD 45 aeyaeaii ia aeanoao on?o 40 oai?eo. Noaoenoe/ii ?noioii? a?aei?iiino? a aeni?an?? ia?ea?a ee?oei-iiia?aaeiee?a HLA-DR i?e ??cieo i?aeaa??aioao AIE ia aoei anoaiiaeaii i? uiaei /anoioe eiai aeni?an??, i? uiaei ?? ??aiy (a?aenioie iiceoeaieo ee?oei), a oie aea /an ye aioeaai CD 34 noaoenoe/ii aeinoia??ii /ano?oa aeyaeyany ia aeanoao I1 i?aeaa??aioo ii??aiyii c I2. Oaeei /eiii, ia?ea? CD 34 iiaea neoaoaaoe aecia/ieeii nooiaiy c??eino? i??eiaeano?a, aoaeo/e aeiaeaoeiaei aeeoa?aioe?eiei e?eoa???i aeey i??eiaeanoieo (I1 ? I2) i?aeaa??aio?a AIE. Ia aaeaeiny aeiaanoe ??cieoe? a aeni?an?? aioeaai?a CD 13, CD 11b oa CD 15 na?aae ??cieo i?aeaa??aio?a AIE. I?ioa i?eaa?oa? oaaao iaeaeua /anoioa ? ??aaiue aeni?an?? CD 13 i?e I2, a CD 15 - i?e I2, I4 ? I5 i?aeaa??aioao AIE. Iiiioeeoa?iee aioeaai CD 14 aeyaeyany i?aeoe/ii a on?o aeiaaeeao aino?i? iiiioeeoa?ii? oa i??eiiiiioeeoa?ii? eaeeai??, a oie aea /an ye i?e i??eiaeanoieo i?aeaa??aioao (I1 ? I2) a?i aecia/aany eeoa a ie?aieo oai?eo. Ie?aii ne?ae a?aecia/eoe ?acoeueoaoe aeine?aeaeaiiy Oaaeeoey 1 ?ioiioaiioei?/ia oa?aeoa?enoeea FAB- i?aeaa??aio?a aino?i? i??ei?aeii? eaeeai?? EeanI 1I 2I 4CDe?euee?noue iic. ee?oei, %/anoioa aeni?an??e?euee?noue iic. ee?oei, %/anoioa aeni?an??e?euee?noue iic. ee?oei, %/anoioa aeni?an??CD 3441.8 ±4.58644.3 ±18.0 30 *58.7 ±18.950HLA-DR36.1 ±2.39238.3 ±8.47529.7 ±3.850 CD 1347.0 ±5.55857.1 ±5.07849.033CD 11b51.5 ±3.77947.4 ±4.19259.6 ±6.371CD 1528.8 ±2.84636.9 ±6.46452.2 ±12.171CD 1430.01330.52249.4 ±8.0 83**i.e.(ANA 09)5.1 ±1.803.9 ±1.5038.4 ±5.588i.e.(IAA 9)i.a.i.a.i.a. EeanI 5I 6CDe?euee?noue iic. ee?oei, %/anoioa aeni?an??e?euee?noue iic. ee?oei, %/anoioa aeni?an??CD 3412.0035.0 ±7.2100HLA-DR28.010051.3 ±15.6100 CD 1325.010043.567CD 11b33.010042.7 ±6.7100CD 1538.010039.067CD 1449.0 100**12.00i.e.(ANA 09)6.0015.00i.e.(IAA 9)i.a.27.0 ±5.7100 I?ei?oee: 1. i.e. - ia eeanoa?eciaaia; 2. i.a. - ia aecia/aee; 3. * - noaoenoe/ii aeinoia??ia ??cieoey a ii??aiyii? c oai?eie c I1; 4. ** - noaoenoe/ii aeinoia??ia ??cieoey i?ae iiiioeeoa?ieie i?aeaa??aioaie (I4+I5) oa i??eiaeanoieie (I1+I2); 5. *anoioa aei?an?? - a?aenioie oai?eo, o yeeo e?euee?noue iiceoeaieo ee?oei aoea > 20%.

aca?iiae?? iaeeanoa?eciaaiiai IEAO ANA 09 c aeanoieie ee?oeiaie AIE, ye?
iieacaee eiai aea??eiao ?aaeoeai?noue c aeanoaie aino?i?
i??eiiiiioeeoa?ii? eaeeai??, ui i?aeoaa?aeeei aeai? eiai ?ic?iaiee?a (I.
I. Iiaeeiaa ? ni?aaao., 1991). Oaeei /eiii, IEAO ANA 09 iiaeia
aeei?enoiaoaaoe ye aeeoa?aioe?eiee e?eoa??e o ae?aaiinoeoe?
iiiioeeoa?ieo I4 oa I5 i?aeaa??aio?a AIE. Iino?eiith aoea aeni?an?y
aioeaaio a?eo?iaeano?a (IEAO IAA 9) ia eaeeai?/ieo ee?oeiao I6. O 32,5 %
aeiaaee?a (13 oai?eo) AIE aeanoi? ee?oeie aeyaeyee eiaeni?an?th iaeiiai
e?ioi?aeiiai (/ano?oa A-ee?oeiiiai), o 5 % (2 oai?eo) — 2 e?ioi?aeieo
ia?ea??a.

I?aenoiiaoth/e, iiaeia c?iaeoe aeniiaie, ui ia caaaeaee ni?aiaaeaee
ii?oieiai-oeeoio?i?/ia oa ?ioiieia?/ia oa?aeoa?enoeea aeano?a i?e AIE.
Naia oea niiioeaei ian eeaneo?eoaaoe ianoaaeai? aeiaaeee AIE ca
?ioiioaiioei?/ieie iciaeaie. A iniiao aeae?eaieo iaie ?ioiioaiioei?/ieo
i?aea?oi AIE, ye? ni?acao/i? c FAB- eeaneo?eaoe??th AIE, aoee iieeaaeai?
?acoeueoaoe iaoeo aeine?aeaeaiue, a oaeiae aeai? e?oa?aoo?e i?i
niaoeeo?/i?noue ia?ea??a aeey iaaieo e?i?e i??eiiiaco oa ?o iiyao /e
cieeiaiiy ia iaaieo aoaiao aeeoa?aioe?aoe?? i??ei?aeieo ee?oei.

Na?aae i??eiaeanoieo eaeeai?e (AIaeE) iaie aoei aeae?eaii AIaeE c
i?i?iaeueieie iciaeaie aeic??aaiiy aeano?a, oaiioei yei? aecia/aee
ia?ea?e ee?oei-iiia?aaeiee?a (HLA — DR oa CD 34) ? iaii??ei?aeiee
aioeaai CD13, oa AIaeE c iciaeaie aeic??aaiiy aeano?a, ye?, ie??i
iayaiino? aeuaaeacaieo ia?ea??a, iaia’yceiai aeni?anoaaee i??ei?aei?
aioeaaie i?ci?oeo noaae?e aeic??aaiiy CD 15 oa CD 11b. ?ioiioaiioei
i?ii??eioeeoa?ii? AIE ? aeineoue /?oei ie?aneaiei (G. De Rossi ?
ni?aaao., 1990; U. Creutzig ? ni?aaao., 1993) ? oa?aeoa?eco?oueny
a?aenooi?noth ia?ea??a ee?oei-iiia?aaeiee?a HLA-DR oa CD 34 ? iayai?noth
i??ei?aeieo aioeaai?a CD 13, CD 15, CD 11b. Aeanoi? ee?oeie i?e aino??e
i??eiiiiioeeoa?i?e eaeeai?? (AIIiiE) ? aino??e iiiioeeoa?i?e eaeeai??
(AIiiE) ae??ciyeeny oei, ui ie??i aioeaai?a ee?oei-iiia?aaeiee?a oa
ia?ea??a a?aioeioeeoa?ii? e?i?? (CD 13, CD 15, CD 11b), aiie iaee
iiiioeeoa?iee ia?ea? CD 14. A e?oa?aoo?? aaaaea?oueny, ui
?ioiioaiioei?/ii ?ic??cieoe AIIiiE ? AIiiE a aeaiee /an iaiiaeeeai.
Iaeiae ie i?aeoaa?aeeee aeai? ?ic?iaiee?a, ui IEAO ANA 09, niaoeeo?/ia
aeey AIIiiE, aeicaiey? aeiaie? /?oei aeeoa?aioe?thaaoe iaeaea?
iiiioeeoa?i? oi?ie aino?i? eaeeai??. ?ioiioaiioei aino?i? a?eo?iaeanoii?
eaeeai?? (AA?E) aecia/aea aca?iiae?y aeano?a c IEAO IAA 9 aei aioeaaio
a?eo?iaeano?a. Ia aeaeue, a iaoiio ?icii?yaeaeaii? ia aoei IEAO aei
aioeaai?a o?iiaioeeo?a. ?ioiioaiioei?/i? i?eioeeie ae?aaiinoeee aino?i?
a?a?eaeii? eaeeai?? iieyaaee o aeyaeaii? ia aeanoao AIE iaeii/anii aeaio
/e a?eueoa e?ioi?aeieo ia?ea??a aai ae aea??eiai aioeaaio CD10,
aiaeia?/ii oiio, ye aaaaeathoue ? ?io? aeine?aeieee (S. Aoki ? ni?aaao.,
1991; U. Creutzig ? ni?aaao., 1993).

?iciiae?e ianoaaeaieo iaie oai?eo a ?ioiioaiioei?/ieo i?aea?oiao aoa
ianooiiei: AIaeE c i?i?iaeueieie iciaeaie aeic??aaiiy aeano?a
(HLA-DR+/-; CD 34+/-; CD 13+/-; CD 15-; CD 11b-; CD 14-; BCA 09-) — 4
oai?eo; AIaeE c iciaeaie aeic??aaiiy aeano?a (HLA-DR+; CD 34+/-; CD 13+;
CD 15+/-; CD 11b+; CD 14-; BCA 09-) — 17 oai?eo; AIE i?ii??eioeeoa?ia
(HLA-DR-; CD 34-; CD 13+; CD 15+/-; CD 11b+/-; CD 14-; BCA 09-) — 1
oai?ee; AIIiiE (HLA-DR+; CD 34+/-; CD 13+/-; CD 15+/-; CD 11b+/-; CD
14+; BCA 09+) — 6 oai?eo; AIiiE (HLA-DR+; CD 34-/+; CD 13+/-; CD 15-/+;
CD 11b-/+; CD 14+; BCA 09-) — 6 oai?eo; AA?E (HLA-DR+/-; CD 34-/+; CD
13+/-; CD 15-/+; CD 11b+/-; CD 14-; BCA 09-; IAA 9+) — 2 oai?eo, aino?a
a?a?eaeia eaeeai?y — 4 oai?eo.

Ii??aiyaoe ?ioiieia?/i? i?aea?oie oa FAB- i?aeaa??aioe AIE,
iani?aiaae?iiy ?ioiioaiioei?/ieo iciae aeanoieo ee?oei oa ?o iaeaaeiino?
aei FAB- i?aeaa??aioo anoaiiaeaii o 20 ?c 40 ianoaaeaieo oai?eo (50 %)
(oaae. 2). Na?aae oeeo iaoe??io?a iniiaio a?oio (30 %) neeaee 12 in?a, o
yeeo ??aaiue aeeoa?aioe?aoe?? i??eiaeano?a, aecia/aiee ca e?eoa??yie
FAB- eeaneo?eaoe?? oa ca aeni?an??th aeeoa?aioe?eieo ia?ea??a,
a?ae??ciyany. Na?aae ieo ia?aaaaeaee aeiaaeee, eiee aeanoi? ee?oeie ia
iaee ii?oieiai — oeeoio?i?/ieo iciae aeic??aaiiy, i?ioa aeni?anoaaee ia
nai?e iiaa?oi? aioeaaie i?ci?o noaae?e aeic??aaiiy (11 ?c 12 oai?eo),
i?ioeeaaeio neooaoe?th niinoa??aaee eeoa a iaeiiai oai?iai. Ianooiia
a?oia oa?aeoa?ecoaaeany iaa?aeiia?aei?noth e?i?eii? iaeaaeiino?
eaeeai?/ieo ee?oei ana?aaeei? i??ei?aeieo iai?yi?a aeeoa?aioe?aoe?? — 10
% (4 oai?eo), ye? ?ioiioaiioei?/ii a?aeiia?aeaee AIiiE, a ca?aeii c FAB-
e?eoa??yie a?aeiineeeny aei I1 (1 aeiaaeie), I2 (2 aeiaaeee) oa I4 ( 1
aeiaaeie) i?aeaa??aio?a AIE. Na?aae ianoaaeaii? a?oie oai?eo o 4
aeiaaeeao (10 %) ae?aaiinoiaaii aino?o a?a?eaeio eaeeai?th. O aeaio
oai?eo (I2 oa I4 i?aeaa??aio) aeanoe aoee CD 10+. Ua o aeaio aeiaaeeao
I6 niinoa??aaee iaeii/anio aeni?an?th aeaio e?ioi?aeieo ia?ea??a. O 27,5
% ?ioiioaiioeiiaaieo aeiaaee?a AIE aoei aeyaeaii eiaeni?an?th aeanoieie
ee?oeiaie iaeiiai e?ioi?aeiiai aioeaaio. Iae/enaeuei?oith i?aea?oiith
AIE c eiaeni?an??th e?ioi?aeiiai ia?ea?a aoea AIaeE c iciaeaie
aeic??aaiiy aeano?a (72,7 %), i?e oeueiio iae/ano?oa aeyaeyany A-
e?i?eiee aioeaai CD 22 (72,7 %), a oaeiae O- ee?oeii? ia?ea?e — CD 1n,
CD 7, Cdw 90. O oai?eo AIaeE c i?i?iaeueieie iciaeaie aeic??aaiiy, AIE
i?ii??eioeeoa?iith oa AA?E e?ioi?aei? ia?ea?e ia aeyaeyeeny.

On? oai?? iaea?aeoaaee e?eoaaiiy ca i?ia?aiith aeey AIE ?c
canoinoaaiiyi eo?n?a “7+3” (?oaii?oeei a aeic? 45 ia/i2 ia aeiao a ia?o?
o?e aei? oa oeeoica? 100 ia/i2 ia aeiao 1 — 7 aei?; 4 eo?ne
?iaeoeoe??/eiinie?aeaoe?? c ?ioa?aaeii i?ae eo?naie 3 oeaei? c
ia?aoiaeii ia i?aeo?eioth/o oa?ai?th ca oe??th ae noaiith aai “5+2” c
?ioa?aaeii 6 oeaei?a).

Aiae?c ?acoeueoao?a e?eoaaiiy oai?eo ie iiaee i?iaanoe o 48 oai?eo,
?aooa c ??cieo i?e/ei aeiaee c-i?ae iaoiai niinoa?aaeaiiy. Iiaio
?ai?n?th (I?) aoei aeinyaiooi o 22 c 48 oai?eo (45,8 %), ?acenoaioieie
aei e?eoaaiiy aeyaeeenue 9 (18,7 %) oai?eo. Nia?oi?noue a ia??iae
oa?ai?? ?iaeoeoe?? ?ai?n?? neeaea 35,4 %. I?e aea/aii? aoaeoeaiino?
e?eoaaiiy oai?eo c ie?aieie FAB- i?aeaa??aioaie AIE aeyaeeinue, ui
iaeiaio

Oaaeeoey 2

Ni?aa?aeiioaiiy i?ae ?ioiioaiioei?/ieie i?aea?oiaie

oa FAB- i?aeaa??aioaie aino?i? i??ei?aeii? eaeeai??

?ioiioaiioei?/i?FAB- i?aeaa??aioeAnueiaii?aea?oieI 1I 2I 3I 4I 5I
6oai?eoAIaeE c i?i. iciaeaie aeic??aaiiy aeano?a

3

1

4AIaeE c iciaeaie aeic??aaiiy aeano?a

10

7

17

AIE

i?ii??eioeeoa?ia

1

1AIIiiE66AIiiE12126AA?E22Aino?a a?a?eaeia eaeeai?y1124Anueiai
oai?eo1412082440

ni?eyoeeaeie i?iaiinoe/ii aoee i??eiaeanoi? I1 oa I2 i?aeaa??aioe.
A?aenioie I? na?aae oeeo oai?eo aoa 26,1 % oa 36,4 % a?aeiia?aeii.
Ca?aeii c iaoeie aeaieie, /anoioa I? aoea aenieith i?e iiiioeeoa?ieo I4
oa I5 i?aeaa??aioao (83,3 % oa 75,0 % a?aeiia?aeii), iaeiae ??
o?eaae?noue aoea aeoaea ??ciith a ie?aieo oai?eo ( a?ae 2 aei 44
i?nyoe?a). Oai?? c I0 oa I6 i?aeaa??aioaie AIE aeinyaee I? o an?o
aeiaaeeao, i?ioa iaei/enaeuei?noue a?oi (ii 2 iniae a eiaei?e) ia
aeicaiey? ocaaaeueithaaoe ?acoeueoaoe.

?icaeyaeath/e ?acoeueoaoe e?eoaaiiy oai?eo o ?ioiieia?/ieo i?aea?oiao
AIE, aoei eiinoaoiaaii, ui iaea?eueoee a?aenioie oai?eo, ye? aeinyaee
I?, aoa o i?aea?oi? AIIiiE (100 %) oa a?a?eaeii? AIE (75 %). Iaioei aoa
a?aenioie I? o i?aea?oi? AIaeE c iciaeaie aeic??aaiiy aeano?a (41,7 %) ?
eeoa 20 % — o i?aea?oi? AIiiE. Eiaeni?an?y e?ioi?aeiiai ia?ea?a i?e AIE
nooo?ai ia aieeaaea ia ?acoeueoaoe e?eoaaiiy oai?eo.

I?e aeine?aeaeaii? aca?iica’yceo i?ae /anoioith aeinyaiaiiy I? oa
aeni?an??th ia iiaa?oi? aeano?a ie?aieo aioeaai?a aoei aeyaeaii, ui
/anoioa I? o oai?eo c CD 15+ aeanoaie noaoenoe/ii aeinoia??ii aeua,
ai?ae o aeiaaeeao eiee aioeaai CD 15 aoa a?aenooi?e. Oaeei /eiii, iiaeia
noaa?aeaeoaaoe, ui aeni?an?y aioeaaio CD 15 ? i?iaiinoe/ii ni?eyoeeaei
oaeoi?ii uiaei aeinyaiaiiy oai?eie AIE iiaii? ?ai?n??. Ui ae noino?oueny
?aooe ?ioiieia?/ieo ia?ea??a, oi ?o i?iaiinoe/iiai cia/aiiy ie ia
aeyaeee.

Oaeei /eiii, iaea?aeai? iaie aeai? na?ae/aoue, ui ia nueiaiaei?oi?e
aeaiue ae?aaiinoeea oa, iniaeeai, aeeoa?aioe?eia ae?aaiinoeea AIE
iiaeiia aacoaaoeny ia ii?oieiai-oeeoio?i?/iiio oa ?ioiieia?/iiio
aeine?aeaeaii? aeanoieo ee?oei. Aea/aiiy iiaa?oiaaeo aioeaai?a
eaeeai?/ieo ee?oei aeicaiey? /?oei aecia/eoe e?i?eio iaeaaei?noue oa
nooi?iue c??eino? aeanoieo ee?oei i?e AIE. Aecia/aiiy aioeaaio CD 15 ia?
i?iaiinoe/ia cia/aiiy uiaei aeinyaiaiiy oai?eie AIE iiaii? ?ai?n??.

AENIIAEE

1. ?ioiieia?/ia oaiioeioaaiiy eaeeai?/ieo ee?oei i?e aino??e i??ei?aei?e
eaeeai?? aeiiiaith? ii?oieiai-oeeoio?i?/ia aeine?aeaeaiiy ? aeicaiey?
ooi/ieoe eeaneo?eaoe?th i?aeaa??aio?a oeueiai caoai?thaaiiy ia iniia?
aecia/aiiy iaeaaeiino? aeano?a aei iaei??? ?c e?i?e i??eiiiaco ? nooiaiy
?o c??eino?.

2. Aeiaeaoeiaeie e?eoa??yie a ii?oieiai-oeeoio?i?/i?e oa?aeoa?enoeoe?
aeanoieo ee?oei, yea ? i?aenoaaith aeey FAB- eeaneo?eaoe?? aino?i?
i??ei?aeii? eaeeai??, ? ye?niee aiae?c ?iciiae?eo ? i?ae?euee?nia
aecia/aiiy aeoeaiino? ia?ieneaeace ? oei?aoeaoaoanoa?ace a aeanoao. Oe?
aeiiiaiaiiy iathoue aaaeeeaa cia/aiiy aeey a?ae??ciaiiy I1/I2 oa I4/I5
i?aeaa??aio?a.

3. Aioeaai CD 34 /ano?oa aeni?ano?oueny ia aeanoao I1 i?aeaa??aioo AIE
ii??aiyii c I2 i?aeaa??aioii.

4.

Aeni?an?y aeanoieie ee?oeiaie aioeaai?a CD 15, ia?ea?a aeic??aaiiy
i??ei-aeano?a, CD 14 oa IEAO ANA 09, eio?? aeanoea? aeey aino?i?
iiiioeeoa?ii? oa i??eiiiiioeeoa?ii? eaeeai??, IEAO IAA 9, aioeaaio
a?eo?iaeano?a, ? iniiaith aeey ?ioiieia?/ii? eeaneo?eaoe?? aino?i?
i??ei?aeii? eaeeai??.

5. Oeeoio?i?/i? oa ?ioiioaiioei?/i? iciaee aeanoieo ee?oei ia
ni?aiaaeathoue o 50 % oai?eo. Iae/ano?oa (o 30 % aeiaaee?a) aeyaeaii
iaa?aeiia?aei?noue i?ae ??aiai aeeoa?aioe?aoe?? i??eiaeano?a, aecia/aiei
ca e?eoa??yie FAB- eeaneo?eaoe?? (I1-I3) oa ca aeni?an??th
aeeoa?aioe?eieo i??ei?aeieo ia?ea??a.

6. O 10 % oai?eo anoaiiaeaia iaa?aeiia?aei?noue ii?oioeeoio?i?/ieo oa
?ioiioaii-oei?/ieo iciae e?i?eii? iaeaaeiino? eaeeai?/ieo ee?oei
ana?aaeei? i??ei?aeieo iai?yie?a aeeoa?aioe?aoe??. Iae/ano?oa
aeyaey?oueny iiiioeeoa?iee aioeaai CD 14 i?e I1 — I2 FAB-
i?aeaa??aioao, ui aeicaiey? ?o eeaneo?eoaaoe ?ioiieia?/ii ye aino?o
iiiioeeoa?io eaeeai?th.

7. Aino?a a?a?eaeia eaeeai?y ae?aaiinoiaaia o 10 % oai?eo c oeeoio?i?/ii
i?aeoaa?aeaeaiith aino?ith i??ei?aeiith eaeeai??th ia iniia? aeni?an??
ia aeanoieo ee?oeiao e?ioi?aeieo ia?ea??a (CD 10 aai aeaio ?ioeo
ia?ea??a). O 27,5 % oai?eo eaeeai?/i? ee?oeie eiaeni?anoaaee iaeei
e?ioi?aeiee ia?ea?.

8. Iayai?noue ia iiaa?oi? eaeeai?/ieo ee?oei i?e aino??e i??ei?aei?e
eaeeai?? aioeaaio CD 15 ? ni?eyoeeaith i?iaiinoe/iith iciaeith uiaei
a?aeiia?ae? oai?eo ia oeeoinoaoe/io oa?ai?th ? aeinyaiaiiy ?ai?n??.

I?AEOE*I? ?AEIIAIAeAOe??

1. ?aeiiaiaeo?oueny aeei?enoiaoaaoe aecia/aiiy nooiaiy aeoeaiino?
ia?ieneaeace oa oa?aeoa?o ?? ?iciiae?eo a aeanoao aeey aeeoa?aioe?aoe??
i??eiaeanoieo oa iiiioee-oa?ieo i?aeaa??aio?a aino?i? i??ei?aeii?
eaeeai??, a oaeiae aecia/aiiy nooiaiy c??eino? i??eiaeano?a
(ae?aaiinoeea I1 oa I2 i?aeaa??aio?a).

2. Aecia/aiiy nooiaiy aeoeaiino? oei?aoeaoaoanoa?ace a aeanoao aeicaiey?
aeeoa?aioe?thaaoe ie?ai? i?aeaa??aioe aino?i? i??ei?aeii? eaeeai??,
cie?aia, I4 oa I5, a oaeiae I1 ? I2.

3. ?aeiiaiaeiaaii i?iaiaeeoe ?ioiieia?/ia oaiioeioaaiiy aeanoieo ee?oei
c iaoith aecia/aiiy ?ioiieia?/iiai i?aeaa??aioo aino?i? i??ei?aeii?
eaeeai??, ine?eueee ?ioiioaiioei ee?oeie ? a?eueo aaaiiei iieacieeii ??
e?i?eiiai iioiaeaeaiiy, i?ae oaiioei ii?oioeeoio?i?/iee.

4.

C iaoith iiia?aaeaeaiiy ?ioaeoe?eieo oa aaii?aa?/ieo oneeaaeiaiue o
oai?eo aino?ith i??ei?aeiith eaeeai??th a ia??iae i?ia?aiii?
oeeoinoaoe/ii? oa?ai?? iaiao?aeii i?iaiaeeoe a aeinoaoiueiio ia’?i?
aeiiii?aeio oa?ai?th caoenoo — aioea?i-oeee oe?ieiai niaeo?o ae??,
aaaaeaiiy o?iiaieiioeaio?aoo.

NIENIE IOAE?EAOe?E CA OAIITH AeENA?OAOe??

1. Eia?inueeee A. I., Aeaianueea ss. ?., Ianeye C. A., Oeeiaaethe ?. I.,
Iaco?ie A. A., Ea?ieue TH. N. Cia/aiiy ?ioiieia?/iiai oaiioeioaaiiy
aeanoieo ee?oei o ae?aaiinoeoe? aino?i? i??ei?aeii? eaeeai?? o aei?ineeo
// Yenia?ei. iieie. — 1996. -o. 18, ? 2. -n.146-151.

2. Eia?inueeee A. I., Aeaianueea ss. ?., Ianeye C. A., Oeeiaaethe ?. I.,
Ea?ieue TH. N., Iaco?ie A. A. Aeeoa?aioe?eia ae?aaiinoeea noaaa??aio?a
aino?i? i??ei?aeii? eaeeai?? // Acta med. Leopol. — 1996. — o. 2, ? 1. —
c. 41 — 44.

3. Eia?inueeee A. I., Aeaianueea ss. ?., Oeeiaaethe ?. I., Ianeye C. A.,
Iaco?ie A. A. Ioe?iea oeeoio?i?/ieo e?eoa???a a ae?aaiinoeoe?
i?aeaa??aio?a aino?i? i??ei?aeii? eaeeai?? // E?e. ni?aaa.-1998.- ?2.-
n. 54-58.

4. Aeaianueea ss. ?., Oeeiaaethe ?. I., Eia?inueeee A. I., Ianeye C. A.,
Iaco?ie A. A., Aaniaa I. I. ?acoeueoaoe canoinoaaiiy i?ia?aie, ui
aeeth/a? oeeoicei a?aa?iiceae oa ?oaii?oeei, aeey e?eoaaiiy
FAB-i?aeaa??aio?a aino?i? i??ei?aeii? eaeeai?? aei?ineeo // I?aeo.
iaaeeoeeia.- 1998.- ? 1-2.- n. 13-16.

5. Oeeiaaethe ?. I., Eia?inueeee A. I. ?ioiieia?/ia eeaneo?eaoe?y
aino?i? i??ei?aeii? eaeeai?? // “Nia?. i?iae. ?aaeeaoeeiiiie iaaeeoeeiu”
/ na. noaoae e 10-eaoeth aaiaoieiae/aneiai ioae. EE? IOe?I AII Oe?aeiu./
— Eeaa, 1997. -n. 48 — 50.

6. Oeeiaaethe ?. I., Eia?inueeee A. I., Ianeye C. A., Oaeae I. I.,
Ia?eia I. I. Oeeoio?i?/i? oa ?ioiioaiioei?/i? e?eoa??? ae?aaiinoeee
noaaa??aio?a aino?i? i??ei?aeii? eaeeai?? // ??? Oe?a?inueeee c’?cae
aaiaoieia?a ? o?ainooc?ieia?a, 24-26 aeiaoiy 1995 ?., Noie (Iao. aeii.).
— E., 1995. — n. 56.

7. Loginski V., Maslyak Z., Vygovska Y., Mazurok A., Cymbaliuk I., Karol
Y. Diagnostic value of blast cells immunophenotyping in adult acute
myeloid leukemias // In: XIII Meeting of the Int. Soc. Haematol. (Europ.
and Afr. Division), September 3-8, 1995. — Istanbul, Turkey. — Book of
Abstr. — 1995. — ? 1056.

Aiioaoe?y

Oeeiaaethe — Aieioei ?. I. Ae?aaiinoe/ia oa i?iaiinoe/ia cia/aiiy
oeeoio?i?/iiai oa ?ioiieia?/iiai oaiioeioaaiiy aeanoieo ee?oei o oai?eo
aino?ith i??ei?aeiith eaeeai??th.- ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.31 — aaiaoieia?y oa o?ainooc?ieia?y. —
Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo aaiaoieia?? oa ia?aeeaaiiy
e?ia?, Ee?a, 1998.

A aeena?oaoe?? i?aaenoaaeaii ?acoeueoaoe oeeoio?i?/iiai oa
?ioiieia?/iiai aeine?aeaeaiiy aeanoieo ee?oei o oai?eo aino?ith
i??ei?aeiith eaeeai??th (AIE).

Iieacaii cia/aiiy aeoeaiino? ia?ieneaeace oa oei?aoeaoaoanoa?ace o
aeanoieo ee?oeiao aeey aeeoa?aioe?eii? ae?aaiinoeee FAB- i?aeaa??aio?a
AIE. Aeyaeaii iniaeeaino? ?ioiieia?/iiai oaiioeio eaeeai?/ieo ee?oei i?e
FAB- i?aeaa??aioao AIE. Cai?iiiiiaaii ?ioiieia?/io eeaneo?eaoe?th AIE,
yea a?aeia?aaea? ?ioiioaiioei?/i? iciaee e?i?eii? iaeaaeiino? oa nooiaiy
c??eino? aeanoieo ee?oei. I?iaaaeaii aiae?c ni?aa?aeiioaiiy i?ae FAB-
i?aeaa??aioaie oa ?ioiioaiioei?/ieie i?aea?oiaie AIE. Anoaiiaeaii, ui
aeni?an?y aioeaaio CD 15 ? i?iaiinoe/ii ni?eyoeeaith iciaeith uiaei
aeinyaiaiiy oai?eie AIE iiaii? ?ai?n??.

Eeth/ia? neiaa: aino?a i??ei?aeia eaeeai?y, aeanoi? ee?oeie, FAB-
eeaneo?eaoe?y, ?ioiioaiioei.

AiIioaoeEy

Oeeiaaethe — Aieioei E. I. Aeeaaiinoe/aneia e i?iaiinoe/aneia cia/aiea
oeeoioeie/aneiai e eiioiieiae/aneiai oaiioeie?iaaiey aeanoiuo eeaoie o
aieueiuo ino?ui ieaeieaeiui eaeeicii.- ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/?iie noaiaie eaiaeeaeaoa iaaeeoeeineeo
iaoe ii niaoeeaeueiinoe 14.01.31 — aaiaoieiaey e o?ainooceieiaey. —
Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo aaiaoieiaee e ia?aeeaaiey
e?iae, Eeaa, 1998.

A aeenna?oaoeee i?aaenoaaeaiu ?acoeueoaou oeeoioeie/aneiai e
eiioiieiae/aneiai enneaaeiaaiey aeanoiuo eeaoie o aieueiuo ino?ui
ieaeieaeiui eaeeicii (IIE).

Iieacaii cia/aiea aeoeaiinoe ia?ieneaeacu e oei?aoeaoaoanoa?acu a
aeanoiuo eeaoeao aeey aeeooa?aioeeaeueiie aeeaaiinoeee FAB-
iiaeaa?eaioia IIE. Auyaeaii iniaaiiinoe eiioiieiae/aneiai oaiioeia
eaeeiciuo eeaoie a FAB- iiaeaa?eaioao IIE. I?aaeeiaeaia eiioiieiae/aneay
eeanneoeeaoeey IIE, io?aaeathuay eiioiioaiioeie/aneea i?eciaee eeiaeiie
i?eiaaeeaaeiinoe e noaiaie c?aeinoe aeanoiuo eeaoie. I?iaaaeai aiaeec
niioiioaiey iaaeaeo FAB- iiaeaa?eaioaie e eiioiioaiioeie/aneeie
iiaea?oiiaie IIE. Onoaiiaeaii, /oi yeni?anney aioeaaia CD 15 yaeyaony
i?iaiinoe/anee aeaaii?eyoiui i?eciaeii aeey aeinoeaeaiey aieueiuie IIE
iieiie ?aiennee.

Eeth/aaua neiaa: ino?ue ieaeieaeiue eaeeic, aeanoiua eeaoee, FAB-
eeanneoeeaoeey, eiioiioaiioeie?iaaiea.

SUMMARY

Cymbaliuk — Voloshyn I. P. Diagnostic and prognostic significance of
cytochemical and immune phenotyping of blast cells in acute myeloid
leukemia patients.- Manuscript.

The dissertation for gaining the scientific degree of the Candidate of
Medical Sciences in speciality 14.01.31 — Hematology and
Transfusiology.- Kyiv Research Institute of Hematology and Blood
Transfusion, Kyiv, 1998.

The dissertation presents the results of cytochemical and immune
investigation of blast cells in 81 adult patients suffering from acute
myeloid leukemia (AML). The importance of peroxydase and
chloracetatesterase activity evaluation in AML blast cells is
appreciated for differentiation of FAB subtypes. The peculiarities of
leukemic cells immunophenotype in AML FAB subtypes was revealed. The
immunologic classification of AML is suggested by defining of the
lineage and differentiation level of the blast cells. The analysis of
relations between FAB subtypes and immunologic subgroups in AML is
performed. There is established that CD 15 expression on blast cells is
favourable prognostic feature to achieving the complete remission in
AML.

Key words: acute myeloid leukemia, blast cells, FAB classification,
immunophenotype.

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