EE?ANUeEEE IAOEIAI — AeINE?AeIEE

?INOEOOO AAIAOIEIA?? OA IA?AEEAAIIss E?IA?

IIC OE?A?IE

AICITHE Aaea??e Iao?iae/

OAeE: 616. 155.392 — 076 — 08

OeEOIOIENE*IA AEOEAI?NOUe EAEEIOeEO?A E?IA? A

AeEIAI?Oe? E?IOII?IE?OA?AOEAIEO CAOAI?THAAIUe

IA OII? OeEOINOAOE*II? OA?AI??

14.01.31 — Aaiaoieia?y oa o?ainooc?ieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia o Ee?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe
IIC Oe?a?ie

?i. I.E.Ooieea IIC Oe?a?ie

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani?

AON?AA Na?oeaia Aiaoie??aia,

i?ioani? eaoaae?e aaiaoieia?? oa o?ainooc?ieia?? Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ii. I.E.Ooieea IIC Oe?a?ie

Io?oe?eie iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?

E?IAeCAEUeNEEE Eaii?ae Iao?iae/,

caa?aeoaa/ iaoeiai-aeine?aeiei a?aeae?eaiiyi nenoaiieo iooeeiieo
caoai?thaaiue Oe?a?inueeiai IAe? iieieia?? oa ?aae?ieia?? IIC Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani?

?iiaiiaa Aeea Oaaei??aia, i?ia?aeiee iaoeiaee ni?a?ia?oiee
aaiaoieia?/ii? ee?i?ee aeey aei?ineeo Ee?anueeiai IAe? aaiaoieia?? oa
ia?aeeaaiiy e?ia? IIC Oe?a?ie

I?ia?aeia onoaiiaa:

?inoeooo ee?ie/ii? ?aae?ieia?? Iaoeiaiai Oeaio?o ?aae?aoe?eii?
iaaeeoeeie AII Oe?a?ie, a?aeae?e aaiaoieia??, i. Ee?a

Caoeno a?aeaoaeaoueny “______” _________________1998?. a____aiae.

Ia can?aeaii? niaoe?ae?ciaaii? A/aii? ?aaee Ae.26.612.01

a Ee?anueeiio IAe? aaiaoieia?? oa ia?aeeaaiiy e?ia?

(254060, i.Ee?a, aoe. I.Aa?eeinueeiai,12).

C aeena?oaoe?ath iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai IAe?
aaiaoieia?? oa ia?aeeaaiiy e?ia?.

Aaoi?aoa?ao ?ic?neaiee “_____”__________________1998 ?ieo

A/aiee nae?aoa?ue

niaoe?ae?ciaaii? A/aii? ?aaee
Eii?na?aiei A.A.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ceiye?ni? caoai?thaaiiy e?ioi?aeii? oeaieie
yaeythoue niaith iaeio c aieiaieo i?iaeai no/anii?
iieiaaiaoieia??. I??eiiia oai?iaa ( IO ) oa o?ii?/iee e?i-oieaeeic (
OEE ) ? iaea?eueo iioe?aieie na?aae e?ioii?ie?oa?aoeaieo
caoai?thaaiue

( A.?. Ai?iaeia, 1985; N.N.Boring, 1992 ).

Aeine?aeaeaiiy inoaii?o aeanyoe??/ oiaaiaii aeiaiaeyoue
i?ia?aeio ?ieue ii?ooaiue ?ioiii? ?aaeoeaiino? a ?icaeoeo iooeeiiiai
?inoo ( I.Ae.Aaeeai?oaa, 1986; D.M.Haverstic,1991;). I?e?iaeia oa
aioeo?eicaeaaeia ee?oeiia oeeoioiene/i?noue eaeeioeeo?a ia?eoa?e/ii?
e?ia?

/ EIE / iathoue iniiaia cia/aiiy a ?aae?caoe?? i?ioeiooeeiiiai
?ioi?oaoo oeyoii ?ici?ciaaaiiy oa ae?i?iaoe?? iooeeiiiia?a?iaeaeaieo
ee?oei ( N.H.Oaoeaiia, 1982; Aeacaiiaa O.A.,1983 ). O i?aoeyo
a?o/eciyieo oa ca?oa?aeieo a/aieo aena?oeththoueny, a iniiaiiio,
??ci? aniaeoe aoii?aeueiiai oa O — ee?oeiiiai ?ioi?oaoo i?e
IO oa OEE

( A.I.Oaaae?i, 1988; G. Dighiero, 1988; M. Kawano, 1989 ), oiae? ye
aeine?aeaeaiiy, i?enay/ai? aea/aiith ?ie? e?ea?ieo eaeeioeeo?a
ia?eoa?e/ii? e?ia? i?e oeeo caoai?thaaiiyo, caee-oathoueny ia/enaeueieie
( T.Paglieroni, 1992; G. Katrinacis,1996; R. Garcia-Sanz,1996 ).
Iaaeinoaoiuei aea/aii aca?iica’ycie aeoeaiino? i?e?iaeieo oa
aioeo?eicaeaaeieo eaeeioeeo?a c iniaeeainoyie ee?i?/iiai ia?aa?ao
caoai?thaaiue, iiaeeea?noth ?icaeoeo ?ioaeoe?eieo ? aaii?aa?/ieo
oneeaaeiaiue.

I?e e?eoaaii? oai?eo ia IO oa OEE aeei?enoiaothoueny oeeoinoaoe/i?
i?aia?aoe oa aetheiei?oeeinoa?i?aei? ai?iiie, ye? iathoue ae?aaeaio
?ioiiaeai?aneaio ae?th, ui aeyaey?oueny a i?eai?/aii?, cie?aia,
ooieoe?iioaaiiy e?ea?ieo eaeeioeeo?a.

Aeoiaey/e c? neacaiiai aeua, aeooaeuei?noue eiiieaeniiai aea/aiiy
aeoeaiino? i?e?iaeieo ( IEE ) oa aioeo?eicaeaae-ieo e?ea?ieo ee?oei (
E ) oa aeayeeo iniaeeainoae aioo??oiuei-ee?oeiiiai iaoaaie?cio
aoaeoi?ieo e?ioioeeo?a ? iaeo?io?e?a o aeeiai?oe? IO oa OEE ? a
oiiaao oeeoinoaoe/ii? oa?ai?? oeeo caoai?thaaiue ? i/aaeaeiith ?
i?iaeeeoiaaia ?ioa?anaie no-/anii? iieiaaiaoieia??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, oaiaie.

Oaia ?iaioe iia’ycaia c iaoeiaith oaiaoeeith eaoaae?e aaiaoieia??
oa o?ainooc?ieia?? Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe — “Aea/aiiy iniaeeainoae ia?aaiao, eeiiiei-aaiaoieiai/ieo ?en oa
oaiioeio noano?aoieo eeioei o iaoei?ioia c eiioii?ieioa?aoeaieie oa
ii(eii?ieioa?aoeaieie caoai?thaaiiyie“ ( ? aea?ae.?a(no?aoei(
0193U040741 ).

Iaiao?aei?noue ?ica’ycaiiy cacia/aieo i?iaeai iaoiiaeee iaoo oa
caaea/? oe??? ?iaioe.

Iaoa aeine?aeaeaiiy. Iaoith aeaiiai aeine?aeaeaiiy noaei aea/aiiy
iniaeeainoae i?e?iaeii? oa aioeo?eicaeaaeii? oeeoioiene/iino?
eaeeioeeoia ia?eoa?e/ii? e?iai a aeeiai?oe? eaeeiciiai i?ioeano ? a
oiiaao oeeoinoaoe/ii? oa?ai?? oeeo caoai?thaaiue aeey ?ic?iaee
aeiaeaoeiaeo i?iaiinoe/ieo e?eoa???a ia?aa?ao e?ioii?ie?oa?aoeaieo
caoai?thaaiue ? i?aeaeuaiith aoaeoeaiino? e?eoaaiiy oai?eo ia IO oa
OEE.

Iniiai? caaaeaiiy aeine?aeaeaiiy.

1.Aea/aiiy iniaeeainoae oeeoioiene/ii? aeoeaiino?, ooieoe?iiaeueiiai
noaio e?ioioeeo?a ? iaeo?io?e?a o aeeiai?oe? iooeeiiiai i?ioeano , a
oaeiae ia oii? ee?i?/ieo i?iya?a ?ioaeoe?eieo oa aaii?aa?/ieo
oneeaaeiaiue.

2. Anoaiiaeaiiy caeaaeiino? i?ae aeoeai?noth e?ea?ieo eaeeioeeo?a oa
iniaeeainoyie ee?i?/iiai ia?aa?ao e?ioii?ie?oa?aoeaieo caoai?thaaiue.

3.Aea/aiiy iniaeeainoae ae?? oeeoinoaoe/ieo i?aia?ao?a ? i?aaei?cieiio
ia oeeoie?oe/io ooieoe?th eaeeioeeo?a e?ia?.

4. ?ic?iaea i?iaiinoe/ieo e?eoa???a ia?aa?ao iooeeiiiai i?ioeano oa
?aeiiaiaeaoe?e aeey i?aeaeuaiiy aoaeoeaiino? o?i?ioa?ai?? oai?eo ia IO
? OEE.

Iaoeiaa iiaecia. Oia?oa aea/aia aeoeai?noue i?e?iaeieo oa
aioeo?eicaeaaeieo e?ea?ieo eaeeioeeo?a o aeeiai?oe? IO ? OEE, a oaeiae
i?ney oeeoinoaoe/ii? oa?ai?? oeeo caoai?thaaiue. O ?acoeueoao?
i?iaaaeaieo aeine?aeaeaiue aecia/aii oa?aeoa? ci?i ooieoe?iioaaiiy
ee?oei ia oii? ee?i?/ieo i?iya?a ?ioaeoe?eieo oa aaii?aa?/ieo
oneeaaeiaiue e?ioii?ie?oa?aoeaieo caoai?th-aaiue. Oia?oa,
aenia?eiaioaeueii ? ee?i?/ii iieacaii, ui oeeoinoaoe/i? i?aia?aoe
iathoue ??ciini?yiiaaio ae?th uiaei aeoeaiino? e?ea?ieo eaeeioeeo?a
ia?eoa?e/ii? e?ia?.

I?aeoe/ia cia/aiiy ?iaioe. I?iaaaeai? aeine?aeaeaiiy aeicaieeee
?ic?iaeoe aeiaeaoeia? i?iaiinoe/i? e?eoa??? ia?aa?ao IO oa OEE.
Iaa?oioiaaii ?ioi?iaoeai? iaoiaee i?iaiicoaaiiy ?icaeoeo ?ioaeoe?eieo
? aaii?aa?/ieo oneeaaeiaiue caoai?thaaiue. ?ic?iaeaii niin?a
i?iaiicoaaiiy iani?eyoeeaiai aieeao oeeoinoaoe/ii? oa?ai?? ia ?ioiio
nenoaio oai?eo ia IO oa OEE, ui aeicaieeei iie?aueoe aoaeoeai?noue
e?eoaaiiy.

Aeaeea?aoe?y eiie?aoiiai iniaenoiai aianeo aeena?oaioa. Iniaenoee
aianie aaoi?a iieyaa? a aiae?c? aeooaeueiino? ? nooiaiy aea/aiiy
oaie ?iaioe, aeai?? ? ii?aoethaaii? iaoiaeee aeine?aeaeaiiy,
i?iaaaeaii? oeeoio?i?/ieo aeine?aeaeaiue ee?oei e?ia?, ia?iaoe?
iaoa??aeo. Aeyaeai? caeiiii??iino? noi?ioeueiaaii o aeniiaeao oa
iieiaeaiiyo ?iaioe, ye? aeiinyoueny ia caoeno. Iioiieia?/i?
aeine?aeaeaiiy e?ioioeeo?a oa iaeo?io?e?a e?ia? aeeiiai? ni?eueii c?
ciia?ia?oieeaie eaoaae?e aaiaoieia?? oa o?ainooc?ieia?? EIAII, ui
aiaeia?aaeaii a iaoa?iaeao cai?ieea iaoeiaeo i?aoeue niia?iaioieeia
EIAII ii caeii/aieo oa ia?aoiaeieo IAe? ca 1990 — 1996 ?.,
iaoa?iaeao THaieaeii( iaoeiai-i?aeoe/ii( eiioa?aioei(, i?enay/aii(
75-?i//th eaoaae?e oa?aii(-1 EIAII.

Ai?iaaoe?y aeena?oaoe??. Aeena?oaoeieia ?iaioa ai?iaiaaia ia
?icoe?aiiio can(aeaii( eaoaae?e aaiaoieia(( oa o?ainooc( ieia((
EIAII (11.09.1998 ?.).

Iaoa??aee aeena?oaoe?? aeeeaaeaii a aeiiia?aeyo ia ???
i?aeia?iaeiiio neiiic?oi? » Nenoaiia — aioenenoaiia ?aaoeyoe?y a aeea?e
oa iaaeea?e i?e?iae? » ( Ee?a,1993 ), eiioa?aioe??, i?enay/ai?e
75-??/iiio tha?eath Ee?anueeiai aea?aeaaiiai ?inoeoooo
oaeineiiaeaiiy e?ea??a

( Ee?a,1993 ), V eiia?an? na?oiai? oaaea?aoe?? e?ea?nueeeo oiaa?enoa (
Aei?i?iiao?ianuee, 1994 ), eiioa?aioe??, i?enay/ai?e 75-??/iiio tha?eath
eaoaae?e oa?ai??-1 Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe ( Ee?a, 1996 ).

Ai?iaaaeaeaiiy a i?aeoeeo. Io?eiaii ?ioaiiy i?i aeaea/o iaoaioo
ia aeiao?ae «Niin?a i?iaiicoaaiiy oeeoinoaoe/ii? oa?ai?? i?e
o?ii?/ieo eaeeicao » ( 22.09.1998 ?. ), yeee ai?iaiaaiee ?
ai?iaaaeaeaiee o i?aeoeeo o a?aeae?eaii? aei?inei? aaiaoieia??
Ee?anueei? iaeanii? e?ea?i?.

Iaoa?iaee aeena?oaoei( ai?iaaaeaeaii a iaaeaaiai/iee i?ioean ia
oeeeei oaeineiiaeaiiy ia eaoaae?i aaiaoieiai( oa o?ainoociieiai( EIAII.

Ioaeieaoei(. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 10 ?ia?o, c ieo
4 noaoo? ( 6 oac aeiiia?aeae.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 149
noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, i’yoe ?icae?e?a, aiae?co i ocaaaeueiaiiy ?acoeueoao?a
aeine?aeaeaiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e ? nieneo
e?oa?aoo?e. Nienie e?oa?aoo?e i?noeoue 204 aeaea?aea. ?iaioa
?ethno?iaaia 30 oaaeeoeyie ? 20 iaethieaie.

CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy.

I?ae iaoei niinoa?aaeaiiyi ciaoiaeeeenue 159 oai?eo ia
e?ioii?ie?oa?aoeai? caoai?thaaiiy, na?aae yeeo 91 oai?ee ia IO a?eii
a?ae 41 aei 90 ?ie?a ? 68 — ia OEE a?eii a?ae 40 aei 79 ?ie?a. 20
oai?eo ia ??ci? ?ioaeoe?eii-caiaeuei? caoai?thaaiiy aac iooeeiiiai
o?aaeaiiy e?ioi?aeii? oeaieie neeaee eiio?ieueio a?oio. Aeey ii??aiyiiy
?acoeueoao?a aeine?aeaeaiue ianoaaeaii 20 caei?iaeo in?a c-iii?ae
aeiii??a.

Ae?aaiic IO oa OEE anoaiiaethaaee ia iniia? ee?i?/ieo oa
aaiaoieia?/ieo aeine?aeaeaiue, ?acoeueoao?a aea/aiiy ioieoao?a
e?noeiaiai iiceo.

On? oai?? ia IO caeaaeii a?ae iniaeeainoae ee?i?/iiai ia?aa?ao
caoai?thaaiiy ? i?iaaaeaii? oeeoinoaoe/ii? oa?ai??, a oaeiae ca?aeii
c e?eoa??yie Durie, Salmon ( 1975 ), ?iciiae?eai? ia 4 a?oie. 1 a?oia
?icae?eaia ia aea? i?aea?oie: aei 1-A ( 22 iniae ) oa?eoee oai?? a
?icai?ioo(e noaae?( c iaoneeaaeiaiei ia?aa?aii caoai?thaaiiy; 1-A (
16 oai?eo ) neeaee iaoe??ioe c ee?i?/ieie i?iyaaie ?ioaeoe?eieo
oneeaaeiaiue. O 2-e a?oi? oaeiae aeae?eaii i?aea?oie: aei 2-A ( 15
in?a ) oa?eoee oai??, ianoaaeai? i?ney caaa?oaiiy iaeiiai eo?no
iie?o?i?ioa?ai?? ca noa-iith NI?; 2-A ( 14 in?a ) neeaee oai??,
ianoaaeaiiy yeeo i?iaaaeaii i?ney eo?no oeeoinoaoe/ii? oa?ai??
oeeeeioinoaiii o eiia?iaoe?? c i?aaei?cieiiii. O 3-th a?oio ( 12 in?a
) oa?eoee oai-?? c ee?i?/ieie i?iyaaie aaii?aa?/iiai neiae?iio.
4 a?oio ( 12 in?a) neeaee oai?? ia IO o oa?i?iaeuei?e noaae??
caoai?thaaiiy.

Oai?? ia OEE oaeiae caeaaeii a?ae iniaeeainoae ee?i?/iiai
ia?aa?ao caoai?thaaiiy ? i?iaaaeaii? oeeoinoaoe/ii? oa?ai?? oa
e?eoa???a Rai ( 1993 ), ?iciiae?eai? ia 4 a?oie, ye? ca iniiaieie
ee?i?ei-aaiaoieia?/ieie ia?aiao?aie a?aeiia?aeathoue a?oiai oai?eo ia
IO. Ia?oo ( 1 ) a?oio neeaee 24 iniae, na?aae ieo 11 oa?eoee aei 1-A,
a 13 — aei 1-A i?aea?oie. Ae?oaa ( 2 ) a?oia ?icae?eaia ia i?aea?oie:
aei 2-A oa 2-A i?aea?oie aa?eoee a?aeiia?aeii 13 ? 11 oai?eo ia OEE.
O?aoth ( 3 ) oa /aoaa?oo ( 4 ) a?oie ooai?eee ii 10 oai?eo ia OEE.

?ioiieia?/i? aeine?aeaeaiiy aeeth/aee:

1. Aecia/aiiy aeoeaiino? IEE ? E-ee?oei o ?aaeoe?yo i?e?iaeii? (
IEOe ) oa aioeo?eicaeaaeii? ( ACEOe ) oeeoioiene/iino? ca
iaoiaeeeith Ai?ae??iea N.I. ( 1983 ). Eaeeioeeoe ia?eoa?e/ii? e?ia?
aeae?eyee ia iiaea?eiiio a?aae??io? u?eueiino? o?eie-o?ia?ao?io .

2. Aecia/aiiy e?eueeino? e?ioioeeo?a ? iaeo?io?e?a, ui aeni?anothoue
?aoeaioi?e aei Fc-o?aaiaioa Ig G i?iaiaeeee a ?aaeoe?? AA-ooai?aiiy ca
iaoiaeeeith Oa?a?ia N.I. ( 1978 ).

3. Eiioeaio?aoe?th ne?iaaoeiaiai ?ioiiaeiaoe?io eeano G aecia/aee
iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a aaa?? ca iaoiaeeeith Mancini G. (
1965 ).

Aeoeai?noue i?eioeiai?aeaaeai?iaeeioeeaioeaeo ( IAAe ) oa
i?eioeiai?aeaaeai?iaeeioe-eaioeaeoinoaoo ( IAAeO )-ieneaeac aecia/aee ca
iaoiaeeeith Novikoff A.B., Masek B. (1958). Aeoeai?noue
i??eiia?ieneaeace ( III ) a iaeo?io?eao aecia/aee ca iaoiaeii Loele W.
(1936). Iae?e oeeoio?i?/ieo ?aaeoe?e ?iaeee ca iaoiaeii Astaldi i
Verga. ( 1957 ).

?acoeueoaoe aeine?aeaeaiue ia?iaeyee ca iaoiaeii aa??aoe?eii?
noaoenoeee c aeei?enoaiiyi e?eoa??th Nouethaeaioa-O?oa?a, a a?oiao
c iaaaeeeith e(euee(noth niinoa?aaeaiue canoiniaaii e?eoa??e
A?eeieniia-Iaiia-O?oi?.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

Aiaeic ?acoeueoaoia aeineiaeaeaiue iieacaa, ui aei ii/aoeo
eieoaaiiy o oai?eo i ia IO o ?ic-ai?iooie noaae?? niinoa??aa?oueny
cieaeaiiy aioeo?eicaeaaeii? oeeoioiene/iino? e?ioioeeo?a ia oii?
i?aeoe/ii iaci?iaii?, o ii??aiyii? c o?c?ieia?/ieie aaee/eiaie, IEOe
e?ioioeeo?a. O oie aea /an ??aaiue IEOe iaeo?io?e?a o 1-A i?aea?oi? aoa
ia 23% ieae/a ?iaeaeno

oeeoioiene/iino? ( ?Oe ) caei?iaeo in?a. I?e aeine?aeaeaii?
ooieoe?iiaeueiiai noaio eaeeioeeo?a e?ia? oai?eo ia IO 1-A i?aea?oie
aeyaeaii a??ia?aeia cieaeaiiy e?eueeino? iaeo?io?e?a, ye? ianooue ia
nai?e iiaa?oi? ?aoeaioi?e aei Fc-o?aaiaioa Ig G o ii??aiyii? c
na?aaeiueinoaoenoe/ieie iieacieeaie, oiae? ye eiioeaio?aoe?y Ig G
a?eueo i?ae o 3 ?ace ia?aaeuoaaea aeai? caei?iaeo ethaeae ( oaae.1 ).

O oai?eo ia IO a oa?i?iaeuei?e noaae?? o iaea?eueoiio nooiai?
aeyaeeanue i?eai?/aiith i?e?iaeia e?ea?ia aeoeai?noue e?ioi?aeii?
iiioeyoe?? EIE. Ai?no Fc+-eaeeioeeo?a o 4-e a?oi? aoa ieae/ei
ii??aiyii c aiaeia?/ieie aeaieie 1-A i?aea?oie ( p<0,01 ) ( oaae.1 ). Aeoeai?noue IAAe oa IAAeO-ieneaeac iaeo?io?e?a o 4-e a?oi? aeyaeeanue a 1,63 ? 1,61 ?ace ieae/ith a?ae-iia?aeieo iieaciee?a 1-A i?aea?oie. I?e aeine?aeaeaii? i?e?iaeii? e?ea?ii? aeoeaiino? eaeeioeeo?a o ?icai?ioo?e noaae?? OEE aeyaeaii ia?aaaaeia ciaioaiiy ooieoe?? IEE, i?e oeueiio IEOe e?ioioeeo?a aoea ia 39% ieae/ith na?aaeiueinoaoenoe/ieo aaee/ei. ACEOe iaeo?io?e?a o 1-A i?aea?oi? aoea ?noioii iaioith a?aeiia?aeieo iieaciee?a caei?iaeo ethaeae ( ? < 0,05 ), i?e oeueiio e?euee?noue Fc-iiceoeaieo iaeo?io?e?a oaeiae aoea cieaeaiith ( oaae.1 ). Ii??aiyeueiee aiae?c oeeoio?i?/ieo iieaciee?a oai?eo ia OEE o ?icai?ioo?e noaae?? caoai?thaaiiy ? caei?iaeo in?a ia aeyaea i?ae ieie nooo?aeo a?aei?iiinoae, ca aeiyoeii IAAe-ieneaeace e?ioioeeo?a, aeoeai?noue yei? ia?aaeuoaaea na?aaeiueinoaoenoe/i? aeai? ia 53% . O oa?i?iaeuei?e noaae?? OEE aecia/aii cieaeaiiy an?o ia?aiao??a ooieoe?iiaeueiiai noaio eaeeioeeo?a e?ia?, a oaeiae eiioeaio?aoe?? Ig G. Ooieoe?y E-e?ioioeeo?a aeyaeeanue a 4,67, a e?euee?noue Fc+-e?ioioeeo?a a 1,52 ?ace ieae/ith aiae o?c?ieia?/ieo iieaciee?a. Ai?no Fc+-iaeo?io?e?a aoa o 2,12 ? 1,37 ?ace ieae/ei aiae aiaeia?/ieo aeaieo caei?iaeo ethaeae ? oai?eo 1-A i?aea?oie, a?aeiia?aeii ( oaae.1 ). Ii??aiyeueiee aiae?c ?ioeo ia?aiao??a ooieoe?iiaeueiiai noaio eaeeioeeo?a aeyaea a??ia?aeia cieaeaiiy eiioeaio?aoe?? Ig G, a oaeiae aeoeaiino? IAAe-ieneaeace iaeo?io?e?a oai?eo ia OEE a oa?i?iaeuei?e noaae?? caoai?thaaiiy a?aeiinii iieaciee?a caei?iaeo in?a ? oai?eo 1-A iiaea?oie. Oaeei /eiii, ?acoeueoaoe iaoeo aeineiaeaeaiue canaiae/othoue oa, ui i?ia?anoaaiiy IO oa OEE noi?iaiaeaeo(oueny i?eaii/aiiyi ooieoei( oeeoioiene/ieo eaeeioeeoia, ciaioaiiyi aeoea- iinoi eeniacaeaaeieo oa?iaioia, c?inoaiiyi aeaoaeoiinoi ?aoeaioi?iiai aia?aoo eiioioeeoia oa iaeo?ioieia. Iaaeinoaoiy aeoeaiinoue eiea?ieo eeioei, yei ca no/anieie aeaieie caaacia/othoue i?ioeiooeeiiee caoeno ni?ey( i?ia?anoaaiith eaeeiciiai i?ioeano, i?e oeueiio ia?aaaaeia ciaioaiiy oeeoioiene/iinoi eiioi(aeii( iiioeyoei( naiae/eoue i?i iani?eyoeeaee ia?aaia caoai?thaaiiy. O oai?eo ia IO c eeiii/ieie i?iyaaie iioaeoeieieo oneeaaeiaiue ( 1-A iiaea?oia ) anoaiiaeaii cia/ia c?inoaiiy aioeoieicaeaaeii( oeeoioiene/iinoi EIE, yea ai?iaiaeii ( p<0,01 ) ia?aaeuoaaei aeai? caei?iaeo in?a oa iieacieee eiio?ieueii? a?oie ( oaae.2 ). O oe?e aea a?oi? aeyaeaii ca?eueoaiiy IEOe iaeo?io?e?a, yea aoei a 1,4 ? 1,46 ?ace aeuei a?aeiia?aeieo iieaciee?a caei?iaeo ethaeae ? aeaieo eiio?ieueii? a?oie. E?euee?noue Fc+-iaeo?io?e?a o oai?eo 1-A i?aea?oie aoea ieae/ith aiae aaee/ei eiio?ieueii? a?oie, a ai?no Fc+-e?ioioeeo?a ia?aaeuoaaa eiio?ieuei? iieacieee o 1,37 ?ace. Oaeiae, o oai?eo ia IO 1-A i?aea?oie aoei aeyaeaii nooo?aa i?aeaeuaiiy aeoeaiino? IAAe-ieneaeace iaeo?io?e?a oa III o a?aeiioaii? aei na?aaeiueinoaoenoe/ieo aeaieo ? iieaciee?a eiio?ieueii? a?oie (p<0,01 ). O oai?eo ia OEE c ee?i?/ieie i?iyaaie ?ioaeoe?eii-caiaeueieo i?ioean?a aecia/aii ca?eueoaiiy aeoeaiino? e?ea?ieo eaeeioeeo?a,iniaeeai oea noino?oueny ooieoe?? E-ee?oei (oaae.2). Aea/aiiy ooieoe?iiaeueii? aeoeaiino? eaeeioeeo?a oai?eo 1-A i?aea?oie aeyaeei iii?oia cieaeaiiy e?eueeino? Fc-iiceoeaieo iaeo?io?e?a, oiae? eiee eiioeaio?aoe?y Ig G o oeeo iaoe??io?a nooo?ai ia a?ae??ciyeanue a?ae a?aeiia?aeieo aeaieo caei?iaeo ethaeae oa iieaciee?a eiio?ieueii? a?oie. I?e aiae?c? aeoeaiino? iaia-?aiieo ieneaeac o oai?eo ia OEE i?eaa?oa? oaaao cia/ia ca?eueoaiiy aeoeaiino? IAAeO-ieneaeace iaeo?io?e?a ia?eoa?e/ii? e?ia?. Na?aaei?e a?noio?i?/iee eiao?oe??io aeey IAAeO-ieneaeace iaeo?io?e?a neeaa 1,73 ± 0,04 i?ioe 0,55 ± 0,03 oa1,54 ± 0,4 o caei?iaeo in?a oa oai?eo eiio?ieueii? a?oie,a?aeiia?aeii. Ioaea, o oai?eo ia IO oa OEE, ianoaaeaieo i?ae /an o?eaaiiy ?ioaeoe?eii-caiaeueieo i?ioean?a aeyaeaii cia/ia i?aeaeuaiiy ooieoe?? E-ee?oei ? aeoeaiino? eeniacaeaaeieo oa?iai-o?a iaeo?io?e?a, yea ia?aa?aa? ia oii? ae?aaeaii? aeaoaeoiino? ?aoeaioi?iiai aia?aoo iaeo?io?eueii? eaiee eaeeioeeo?a e?ia?. Ni?aa?aeiioaiiy IEOe/ACEOe e?ioioeeo?a o oai?eo ia IO, ianoaaeaieo ia oii? aaii?aa?/iiai neiae?iio, cia/ii ia?aaeuoaaei aiaeia?/iee iieaciee o caei?iaeo ethaeae oa oai?eo c iaoneeaaeiaiei ia?aa?aii caoai?thaaiiy ca ?aooiie ia?aaaaeiiai ca?eueoaiiy aeoeaiino? IE-e(ioioeeo(a ( oaae.2 ). Ii??aiyeueiee aiae?c ai?noo eaeeioeeo?a, ui iathoue ?aoeaioi?e aei Fc-o?aaiaioa Ig G, a oaeiae oeeoio?i?/ieo ia?aiao??a ia aeyaea nooo?ai? ??cieoe? i?ae iieacieeaie 3-? a?oie oa aeaieie caei?iaeo ethaeae ? oai?eo 1-A i?aea?oie. IEOe e?ioioeeo?a oai?eo ia OEE, ye? aoee ianoaaeai? ia oii? aaii?aa?/ieo oneeaaeiaiue, ia 43,5 % ia?aaeuoaaea iieacieee oai?eo 1-A i?aea?oie,e?euee?noue Fc+-e?ioioeeo?a aoea ieae/ith aeaieo caei?iaeo ethaeae ? 1-A i?aea?oie, a?aeiia?aeii a 1,33 ? 1,54 ?ace. IEOe iaeo?io?e?a oai?eo ia OEE, ye? neeaee 3-th a?oio cia/ii ia?aaeuoaaea iieacieee 1-A i?aea?oie, a ACEOe iaeo?io?e?a aeyaeeanue ia 22 % ieae/ith ( oaae. 2 ). Oaeei /eiii, o oai?eo ia IO c yaeuaie aaii?aa?/iiai neiae?iio ca?a?no?iaaii ia?aaaaeia ca?eueoaiiy aeoeaiino? IE-e?ioioeeo?a, ui na?ae/eoue i?i o/anoue i?e?iaeieo e?ea?ieo e?ioioeeo?a o i?ioeanao cai?oaiiy e?ia?. I?e OEE o oai?eo c ee?i?/ieie i?iyaaie aaii?aa?/iiai neiae?iio aeyaeaii i?aeaeuaiiy aeoeaiino? i?e?iaeieo e(ea?ieo eaeeioeeo(a ia?eoa?e/ii( e?ia(( yea ia?aa(aa( ia oii( ciaioaiiy e(eueeino? Fc+-e?ioioeeo?a. No/ania oeeoinoaoe/ia oa?ai?y i?ecaiaeeoue aei ee?i?ei-aaiaoieia?/ii? noaa?e?caoe?? iooeeiiiai i?ioeano o a?eueoino? oai?eo ia e?ioii?ie?oa?aoeai? caoai?thaaiiy. Aea oeeoinoaoe/i? oa ai?iiiaeuei? i?aia?aoe, ye? aeei?enoiaothoueny aeey e?eoaaiiy oai?eo ia IO oa OEE, iathoue cia/io ?ioiinoi?aneaio ae?th. I?iaaaeai? iaie aeine?aeaeaiiy iieacaee, ui i?ae aieeaii iie?o?i?ioa?ai?? ca noaiith NI? a?aeaoaa?oueny cia/ia cieaeaiiy i?e?iaeii? e?ea?ii? aeoeaiino? e?ioioeeo?a oai?eo ia IO ( 2-A iiaea?oia ). Iiae?aia aeeiai?ea aoea aeyaeaia i?e aeine?aeaeaii? ai?noo Fc+- e?ioioeeo?a ( ia 29% iaioa a?aeiia?aeieo iieaciee?a 1-A i?aea?oie ) ( oaae.3 ). Nooo?aeo a?aei?iiinoae aeoeaiino? IAAe, IAAeO-ieneaeac, III i?ae 2-A i?aea?oiith oa a?oiith oai?eo ia IO, ianoaaeaieo aei ii/aoeo oeeoinoaoe/ii? oa?ai??, ia aeyaeaii. ?ioa caeiiii??i?noue ci?i aeoeaiino? eaeeioeeo?a e?ia? niinoa??aaeanue o oai?eo 2-A i?aea?oie. O oeeo iaoe??io?a aeyaeaii cia/ia i?eai?/aiiy e?ea?ii? ooieoe?? iaeo?io?eueii? iiioeyoe?? eaeeioeeo?a e?ia?, yea noi?iaiaeaeoaaeinue cieaeaiiyi e?eueeino? Fc+-iaeo?io?e?a (oaae. 3). Aeoeai?noue III o oai?eo 2-A i?aea?oie aeyaeeanue ia 78% ieae/ith a?aeiia?aeieo aeaieo 1-A i?aea?oie. Aiae?c ci?i e?ea?ii? ooieoe?? e?ioioeeo?a oa iaeo?io?e?a e?ia? oai?eo ia OEE, ianoaaeaiiy yeeo aoei i?iaaaeaii i?ney cae?i/aiiy eo?no oeeoinoaoe/ii? oa?ai?? ca noaiith NI?, aeyaea, ui aeoeai?noue E-e?ioioeeo?a aoea ieae/ith i?ae oaeai? iieaciee?a 1-A i?aea?oie (oaae.3). Ii??aiyeueiee aiae?c ooieoe?iioaaiiy iaia?aiieo ieneaeac iieacaa cia/ia cieaeaiiy aeoeaiino? IAAe-ieneaeace e?ioioeeo?a o oai?eo 2-A i?aea?oie ( p < 0,01 ). Iniaeea?noth ooieoe?iiaeueiiai noaio eaeeioeeo?a oai?eo ia OEE, ianoaaeaieo i?ney caaa?oaiiy oeeoinoaoe/ii? oa?ai?? oeeeeioinoaiii o eiia?iaoe?? c i?aaei?cieiiii aoei cia/ia i?eai?/aiiy ACEOe iaeo?io?e?a, yea aeyaeeanue o 3,11 ?ace ieae/ith a?aeiia?aeieo iieaciee?a 1-A i?aea?oie. E?euee?noue Fc+-iaeo?io?e?a o 2-A i?aea?oi? iii?oii ia a?ae??ciyeanue a?ae iieaciee?a 1-A i?aea?oie, oiae? ye eiioeaio?aoe?y Ig G aeyaeeanue o 1,35 ?ace ieae/ith (oaae.3). Oaeei /eiii, oeeoinoaoe/ia oa?ai?y IO oa OEE i?ecaiaeeoue aei i?eai?/aiiy ooieoe?iioaaiiy e?ea?ieo eaeeioeeo?a, cieaeaiiy aeoeaiino? oa?iaioaoeaieo i?ioean?a a aoaeoi?ieo ee?oeiao. Aiae?c io?eiaieo aeaieo aeicaieea aeyaeoe caaaeuei? caeiiii??iino? aieeao e?eoaaiiy ia e?ea?io ooieoe?th eaeeioeeo?a oai?eo ia IO oa OEE. Oeeeeioinoai o eiia?iaoe?? c i?aaei?cieiiii aeeeeea? ia?aaaaeio aeai?an?th oeeoie?oe/ii? aeoeaiino? ? iineeaiiy aeaoaeoiino? ?aoeaioi?iiai aia?aoo iaeo?io?e?a, oiae? ye aeeth/aiiy a oa?ai?th oeeo caoai?thaaiue a?ie??noeio i?ecaiaeeoue aei cia/iiai i?eai?/aiiy aeoeaiino? e?ioi?aeii? iiioeyoe?? eaeeioeeo?a ia?eoa?e/ii? e?ia?. ?acoeueoaoe aeine?aeaeaiue aieeao ?ieoaoaaiiy eaeeioeeo?a oai?eo ia IO c ?ic/eiaie oeeoinoaoe/ieo i?aia?ao?a oa i?aaei?cieiio ia nenoaio e?ea?ieo eaeeioeeo?a na?ae/aoue i?i oa, ui i?ney ?ieoaaoe?? aoaeoi?ieo ee?oei c ?ic/eiii oeeeeioinoaio a?aeaoaa?oueny ia?aaaaeia ciaioaiiy oeeoioiene/ii? aeoeaiino? iaeo?io?e?a e?ia?. I?a?ieoaaoe?y eaeeioeeo?a c ?ic/eiii a?ie??noeio i?ecaiaeeoue aei cia/iiai cieaeaiiy e?ioioeeoiiiina?aaeeiaaii? oeeoioiene/iino?. Iniaeea?noth ae?? i?aaei?cieiio ? ae?aaeaia i?eai?/aiiy aioeo?eicaeaaeii? e?ea?ii? aeoeaiino? e?ioioeeo?a, yea ia?aaeueei iieacieee aeey oeeeeioinoaio oa a?ie??noeio o 2,2 ? 3,5 ?ace, a?aeiia?aeii. I?ae aieeaii ?ieoaaoe?? aoaeoi?ieo eaeeioeeo?a oai?eo ia OEE c ?ic/eiii a?ie??noeio e?ea?ia aeoeai?noue ee?oei ?noioii ia ci?ithaaeanue. I?a?ieoaaoe?y eaeeioeeo?a c ?ic/eiii oeeeeioinoaio i?ecaiaeeea aei ae?aaeaii? noi?an?? IEOe iaeo?io?e?a. Oa?aeoa?iith iniaeea?noth ae?? i?aaei?cieiio aoa iacia/iee aieea eiai ia ooieoe?th oeeoioiene/ieo eaeeioeeo?a. Oae, ?iaeaen i?eai?/aiiy IEOe e?ioioeeo?a oai?eo ia OEE neeaa 6,01±1,32,oiae? ye aiaeia?/iee iieaciee o caei?iaeo ethaeae aei??aithaaa 33,25 ± 0,81. Oaeei /eiii, aeine?aeaeaiiy in vitro aeicaieeee anoaiiaeoe iniaeeaino? ae?? oeeoinoaoe/ieo i?aia?ao?a oa i?aaei?cieiio. Oae, oeeoie?oe/ia aeoeai?noue aoaeoi?ieo ee?oei caei?iaeo eth-aeae i?ney ?ieoaaoe?? c ?ic/eiaie i?aia?ao?a i?eai?/oaaeanue o cia/ii a?eueoiio nooiai?, i?ae a?aeiia?aeia ooieoe?y eaeeioeeo(a oai?eo ia e?ioii?ie?oa?aoeai? caoai?thaaiiy. ?ieoaaoe?y eaeeioeeo?a oai?eo ia IO ? OEE c ?ic/eiii oeeeeioinoaio i?ecaiaeeoue aei ia?aaaaeiiai cieaeaiiy e?ea?ii? aeoeaiino? iaeo?io?e?a. Io?eiai? aeai? aeicaieythoue ia?aaeaa/eoe ?nioaai-iy ?ioeo iaoai?ci?a ?ioiinoi?aneaii? ae?? oeeeeioinoaio, ine?eueee aeai? e?oa?aoo?e na?ae/aoue i?i a?aenooi?noue a?ieia?/ii? aeoeaiino? i?aia?aoo in vitro. I?a?ieoaaoe?y eaeeioeeo?a oai?eo ia IO c ?ic/eiii a?ie??noeio i?ecaiaeeea aei aeai?an?? oeeoie?oe/ii? ooieoe?? e?ioioeeo?a, iiae?aieo iniaeeainoae ae?? i?aia?aoo ia e?ioi?aeio iiioeyoe?th eaeeioeeo?a e?ia? oai?eo ia OEE ia aeyaeaii. Oa?aeoa?iith ?enith aieeao i?aaeiicieiio ia oeeoioiene/io aeoeai?noue eaeeioeeo?a in vitro aoei cia/ia i?eai?/aiiy ooieoe?? E-e?ioioeeo?a oai?eo ia IO i?e iacia/i?e /ooeeaino? ee?oei oai?eo ia OEE aei i?aia?aoo. AENIIAEE 1. Ia?aa?a i??eiiii? oai?iae oa o?ii?/iiai e?ioieaeeico noi?iaiaeaeo?oueny i?eai?/aiiyi e?ea?ii? aeoeaiino? eaeeioeeo?a ia?eoa?e/ii? e?ia?, yea iineeth?oueny a i??o i?ia?anoaaiiy iooeeiiiai i?ioeano. Caoai?thaaiiy oa?aeoa?ecothoueny cieaeaiiyi ai?noo eaeeioeeo?a, ye? iathoue ia nai?e iiaa?oi? ?aoeaioi?e aei Fc- o?aaiaioa Ig G ? ciaioaiiyi iieaciee?a aio-o??oiueiee?oeiiiai iaoaaie?cio eaeeioeeo?a. 2. Oeeoinoaoe/ia oa?ai?y ye i??eiiii? oai?iae, oae ? o?ii?/iiai e?ioieaeeico c aeei?enoaiiyi oeeeeioinoaio a eiia?iaoe?? c i?aaei?cieiiii i?ecaiaeeoue aei ia?aaaaeiiai cieaeaiiy e?ea?ii? aeoeaiino? iaeo?io?e?a ia?eoa?e/ii? e?ia?, ciaioaiiy ??aiy iaeo?io?e?a, ye? aeni?anothoue ?aoeaioi?e aei Fc-o?aaiaioa Ig G. Caeo/aiiy aei o?i?ioa?ai?? i??eiiii? oai?iae oa o?ii?/iiai e?ioieaeeico a?ie??noeio aeeeeea? cia/io aeai?an?th aeoeaiino? i?e?iaeieo oa aioeo?eicaeaaeieo e?ioioeeo?a, ciaioaiiy e?eueeino? Fc-iiceoeaieo e?ioioeeo?a. 3. Oeeoinoaoe/i? i?aia?aoe in vitro iathoue ??ciini?yiiaaio noi?aneaio ae?th ia e?ea?io aeoeai?noue eaeeioeeo?a oai?eo ia i??eiiio oai?iao oa o?ii?/iee e?ioieaeeic. ?ieoaaoe?y eaeeioeeo?a c ?ic/eiii oeeeeioinoaio i?ecaiaeeoue aei ia?aaaaeiiai i?eai?/aiiy oeeoioiene/ii? ooieoe?? iaeo?io?e?a. ?ieoaaoe?y ee?oei oai?eo ia i??eiiio oai?iao c ?ic/eiii a?ie??noeio aeeeeea? cieaeaiiy e?ea?ii? aeoeaiino? e?ioioeeoa?ii? eaiee eaeeioeeo?a ia?eoa?e/ii? e?ia?. 4. ?ioaeoe?eii-caiaeuei? i?ioeane o in?a aac o?aaeaiiy e?iaioai?iiai aia?aoo noi?iaiaeaeothoueny cieaeaiiyi aeoeaiino? E-e?ioioeeo?a. ?ioaeoe?eiee i?ioean o oai?eo ia e?ioii?ie?oa?aoeai? caoai?thaaiiy noi?iaiaeaeo?oueny i?aeaeuaiiyi ooieoe?? aioeo?eicaeaaeieo eaeeioeeo?a ? c?inoaiiyi aeoeaiino? eeniacaeaaeieo oa?iaio?a iaeo?io?e?a e?ia?. 5. Aaii?aa?/iee neiae?ii, yeee c'yaey?oueny o oai?eo ia i??eiiio oai?iao ia oii? aeenooieoe?? o?iiaioeeo?a, ia?aa?aa? i?e cia/iiio i?aeaeuaii? aeoeaiino? i?e?iaeieo e?ea?ieo eiioioeeo?a. I?e o?ii?/iiio e?ioieaeeic? anoaiiaeaii c?inoaiiy oeeoioiene/ii? ooieoe?? i?e?iaeieo e?ea?ieo ee?oei, yea noi?iaiaeaeo?oueny ciaioaiiyi e?eueeino? Fc+-e?ioioeeo?a. 6. Aeyaeai? ci?ie oeeoioiene/ii? aeoeaiino? eaeeioeeo?a ia?eoa?e/ii? e?ia? yaeythoue niaith aeiaeaoeia? i?iaiinoe/i? e?eoa??? ia?aa?ao i??eiiii? oai?iae oa o?ii?/iiai e?ioieaeeico. Cieaeaiiy ia?aaaaeii e?ea?ii? aeoeaiino? e?ioioeeo?a na?ae/eoue i?i iani?eyoeeaee ia?aa?a iooeeiiiai i?ioeano ? iaaeeaeaiiy oa?i?iaeueii? noaae?? caoai?thaaiiy. I?AEOE*I? ?AEIIAIAeAOe?? 1. Cieaeaiiy oeeoioiene/ii? ooieoe?? e?ioi?aeii? iiioeyoe?? eaeeioeeo?a e?ia? aeioe?eueii canoiniaoaaoe ye ?aii(e e?eoa?(e ?icaeoeo oa?i?iaeueii? noaae?? i??eiiii? oai?iae oa o?ii?/iiai e?ioieaeeico. 2. Ia?aae ii/aoeii oeeoinoaoe/ii? oa?ai?? aeioe?eueii i?iaiaeeoe aecia/aiiy aeoeaiino? IE oa E-eaeeioeeo?a aeey iioeiaeueiiai aeai?o i?aia?ao?a c o?aooaaiiyi ??ciini?yiiaaii? ae?? a?ie??noeio oa oeeeeioinoaio ia ?o ooieoe?iiaeueio aeoeai?noue. 3. Aeey iioeiaeueiiai aeai?o oeeoinoaoe/ieo i?aia?ao?a aeioe?eueii aecia/aoe aeoeai?noue i?e?iaeieo oa aioeo?eicaeaaeieo e?ea?ieo eaeeioeeo?a ia?aae oa i?ney ?ieoaoaaiiy ee?oei c ?ic-/eiaie oeeoinoaoee?a c aecia/aiiyi nooiaiy iani?eyoeeaiai aieeao i?aia?ao?a ia e?ea?io ooieoe?th e?ioioeeo?a oa iaeo?io?e?a oeyoii ae?aoiaoaaiiy ?iaeaen?a i?eai?/aiiy oeeoioie-ne/iino?. 4. Aeey i?iaiicoaaiiy ?icaeoeo ?ioaeoe?eieo oneeaaeiaiue i??eiiii? oai?iae oa o?ii?/iiai e?ioieaeeico ?aeiiaiaeiaaii i?iaiaeeoe aecia/aiiy iieaciee?a ooieoe?iiaeueiiai noaio eaeeioeeo?a, iaea?eueo ?ioi?iaoeaieie c yeeo ? iieacieee aeoeaiino? E-eaeeioeeo?a ? eeniacaeaaeieo oa?iaio?a iaeo?io?e?a. 5. Iaea?eueo ?ioi?iaoeaiei iaoiaeii i?iaiicoaaiiy aaii?aa?/ieo oneeaaeiaiue i??eiiii? oai?iae ? aecia/aiiy aeoeaiino? i?e?iaeieo e?ea?ieo eaeeioeeo?a. Aenieee ?ecee ?icaeoeo aaii?aa?/ieo oneeaaeiaiue o oai?eo ia o?ii?/iee e?ioieaeeic niinoa??aa?oueny ia oii? cia/iiai i?aeaeuaiiy aeoeaiino? i?e?iaeieo e?ea?ieo e?ioioeeo?a, ui aeioe?eueii aeei?enoiao-aaoe aeey i?iaiicoaaiiy ?icaeoeo aaii?aa?/ieo oneeaaeiaiue o oeeo oai?eo. Nienie iniiaieo ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??: 1. Aicithe A.I., Aonaaa N.A.( Aeoaeiaa A.A. Aeoeaiinoue anoanoaaiiie e aioeoaeicaaeneiie oeeoioiene/iinoe eaeeioeeoia i?e eeioieaeeica e ieaeiiiie aieacie. // E?ea?nueea ni?a-aa.- 1995. - ?. 5-6.- N. 103-104. 2. Aicithe A.I., Aon(aa N.A.( Aeoaeiaa A.A. Oeeoioiene/ia ooieoe?y eaeeioeeo?a o ii?i? oa i?e o?ii?/ieo iooeeiieo caoai?thaaiiyo e?ia?. // E?ea?nueea ni?aaa. - 1996. - ?. 3-4.- N. 9-12. 3. Aicithe A.I. Iniaaiiinoe aeaenoaey eiioiiaeai?anneaiuo i?aia?aoia ia eeeea?ioth aeoeaiinoue eaeeioeeoia e?iae aieueiuo ieaeiiiie aieaciueth. (( E(ea?nueea ni?aaa. - 1997. - ?.6. - N. 83-86. 4. Aicithe A.I. Aeeyiea oeieioa?aiee ia eeeea?ioth aeoeaiinoue eaeeioeeoia ia?eoa?e/aneie e?iae aieueiuo ieaeiiiie aieaciueth. // Eiea?nueea ni?aaa. - 1998. - ?.2. - N. 88 - 91. 5. Aicithe A.I., Aon?aa N.A., Aeoaeiaa A.A. ?ieue oeeoioiene/ieo ?aaeoe?e a aaiac? iooeeiieo caoai?thaaiue A-nenoaie ?ioi?oaoo. // Ca??iee iaoeiaeo i?aoeue, i?enay/aiee 75-??/iiio tha?eath EAe?OE, Ee?a. -1993.- N.25-27. 6. Aicithe A.I., Aeoaeiaa A.A. Aon?aa N.A. Aeeyiea oeieioa?aiee ia eeeea?ioth aeoeaiinoue eaeeioeeoia e?iae aieueiuo n o?iie/aneei eeioieaeeicii. // Ca??iee iaoeiaeo i?aoeue ni?a?ia?oiee?a EIAII ii cae?i/aieo oa ia?ao?aeieo IAe? ca 1990-1996 ?., Ee?a.-1997.- N.119-120. 7. Aicithe A.I., Aon?aa N.A.,Oaaeueei A.A.,Aeoaeiaa A.A. Aeeyiea oeieioa?aiee ia eeeea?ioth aeoeaiinoue eaeeioeeoia ia?eoa?e/aneie e?iae aieueiuo ieaeiiiie aieaciueth. // Ca??iee iaoeiaeo i?aoeue ni?a?ia?oiee?a EIAII ii cae?i/aieo oa ia?ao?aeieo IAe? ca 1990-1996 ?. , Ee?a. -1997.-N. 120-123. 8. Aicithe A.I., Aon?aa N. A., Aeoaeiaa A.A. Nenoaia eeeea?iuo eaeeioeeoia a aeeiaieea iiooieaauo caaieaaaiee A-nenoaiu eiioieoaoa. // III i?aeia?iaeiee neiiic?oi “ Nen-oaiia-aioenenoaiia ?aaoeyoe?y a aeea?e oa iaaeea?e i?e?iae? “, - Ee?a.- 1993.- C. 141-143. 9. Aicithe A.I. Aonaaa N.A., Nooiaee I.A. Eeeea?iay aeoeaiinoue eaeeioeeoia e?iae i?e aaii??aae/aneii neiae?iia o aieueiuo ieaeiiiie aieaciueth. // THaieaeia iaoeiai-i?ae-oe/ia eiioa?aioeiy, i?enay/aia 75-?i//th eaoaae?e oa?aii?-1, Ee?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii? ina?oe. -Ee?a.- 1996.- N.97-98 . 10. Aeaieethe E.E., Aonaaa N.A., Aicithe A.I. Aaeueoei I.Ae. Ninoiyiea nenoaiu eiiieaiaioa a aeeiaieea o?iie/aneiai eeioieaeeica. // THa?eaeia iaoeiai-i?aeoe/ia eiioa?aioe?y, i?enay/aia 75-??//th eaoaae?e oa?ai??-1 EIAII.- Ee?a.- 1996.- N.129-131. AIIOAOe(ss Aicithe A.I. Oeeoioiene/ia aeoeai?noue eaeeioeeo?a e?ia? a aeeiai?oe? e?ioi-i?ie?oa?aoeaieo caoai?thaaiue ia oii? oeeoinoaoe/ii? oa?ai?? - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.31 - aaiaoieia?y oa o?ainoociieiaiy.- Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo aaia-oieia?? oa ia?aeeaaiiy e?ia? IIC Oe?a(ie, Ee?a, 1998. Aeena?oaoeith i?enay/aii aeine?aeaeaiith e?ea?ii? aeoeaiino? eaeeioeeo?a ia?eoa?e/ii? e?ia? oai?eo ia i??eiiio oai?iao ( IO ) oa o?ii?/iee e?ioieaeeic ( OEE ) a aeeiai?oe? iooeei-iiai i?ioeano, a oaeiae a oiiaao no/anii? oeeoinoaoe/ii? oa?ai??. Ciaeaeaii caeiiii??iino? aeeiai?ee oeeoioiene/ii? aeoeaiino? e?ioioeeo?a oa iaeo?io?e?a a caeaaeiino? a?ae noaae?? eaeeiciiai i?ioeano, aeyaeaii iani?eyoeeaa i?iaiinoe/ia cia/aiiy iecueeeo iieaciee?a e?ea?ii? aeoeaiino? e?ioi?aeii( iiioeyoe?? eaeeioeeo?a e?ia? oai?eo ia IO oa OEE. Ciaeaeaii iniaeeaino? ci?i ooieoe?iioaaiiy i?e?iaeieo oa aioeo?eicaeaaeieo e?ea?ieo ee?oei ia oii? ?ioaeoe?eieo ? aaii?aa(/ieo oneeaaeiaiue caoai?thaaiue. Aeine?aeaeaiiyie in vivo oa in vitro iieacaii ??ciiiai?aaeaiee oa?aeoa? ae?? oeeoinoaoe/ieo i?aia?ao?a ia e?ea?io aeoeai?noue eaeeioeeo?a ia?eoa?e/ii? e?ia? oai?eo ia IO oa OEE. Eeth/iai neiaa: ii(eiiia oai?iaa, o?iii/iee eiioieaeeic, i?e?iaeii eiea?ii eeioeie, aioeoieicaeaaeii eiea?ii eeioeie, oeeoioiene/i?noue, oeeoinoaoe/ia oa?ai?y. AIIIOAOeEss Aicithe A.I. Oeeoioiene/aneay aeoeaiinoue eaeeioeeoia e?iae a aeeiaieea eeioii?ieeoa?aoeaiuo caaieaaaiee ia oiia oeeoinoaoe/aneie oa?aiee - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.31 - aaiaoieiaey e o?ainooceieiaey.-Eeaaneee iao/ii-enneaaeiaaoaeueneee einoeooo aaiaoieiaee e ia?aeeaaiey e?iae IC Oe?aeiu, Eeaa, 1998. Aeenna?oaoeey iinayuaia enneaaeiaaieth eeeea?iie aeoeaiinoe eaeeioeeoia ia?eoa?e/aneie e?iae aieueiuo ieaeiiiie aieaciueth ( IA ) e o?iie/aneei eeioieaeeicii ( OEE ) a aeeiaieea iiooieaaiai i?ioeanna, a oaeaea a oneiaeyo nia?aiaiiie oeeoinoaoe/aneie oa?aiee. Iaia?oaeaiu caeiiiia?iinoe aeeiaieee oeeoioiene/aneie aeoeaiinoe eeioioeeoia e iaeo?ioeeia a caaeneiinoe io noaaeee eaeeiciiai i?ioeanna, auyaeaii iaaeaaii?eyoiia i?iaiinoe/aneia cia/aiea ieceeo iieacaoaeae eeeea?iie aeoeaiinoe eeioieaeiie iiioeyoeee eaeeioeeoia e?iae aieueiuo IA e OEE. Auyaeaiu iniaaiiinoe eciaiaiee ooieoeeiie?iaaiey anoanoaaiiuo e aioeoaeicaaeneiuo eeaoie ia oiia eioaeoeeiiiuo e aaii??aae/aneeo ineiaeiaiee IA e OEE. Enneaaeiaaieyie in vivo e in vitro iieacai ?aciiiai?aaeaiiue oa?aeoa? aeaenoaey oeeoinoaoe/aneeo i?aia?aoia ia eeeea?ioth aeoeaiinoue eaeeioeeoia ia?eoa?e/aneie e?iae aieueiuo IA e OEE. Eeth/aaua neiaa: ieaeiiiay aieaciue, o?iie/aneee eeioieaeeic, anoanoaaiiua eeeea?iua eeaoee( aioeoaeicaaeneiua eeeea?iua eeaoee( oeeoioiene/iinoue( oeeoinoaoe/aneay oa?aiey. ANNOTATION Vozniuk V.P. Blood leukocyte cytotoxic activity in lymphoproliferative disease dynamics against cytostatic therapy backgraund - Manuscript. A thesis for the degree of Ph.D ( Candidate of medical sciences ), speciality 14.01.31 - hematology and transfusiology. Kyiv Research Institute of Hematology and Blood Trasfusion, Ministry of Public Health of Ukraine, Kyiv, 1998. The dissertation is devoted to the study of peripheric blood leukocyte killer activity in patients with multiple myeloma ( MM ) and chronic lymphocytic leukemia ( CLL ) in tumorous process dynamics with the use of modern cytostatic therapy. The regularities of lymphocyte and neutrophil cytotoxic activity depending on leukosis process stage have been found out as well as unfavourable prognosis for low values of blood leukocyte lymphoid population killer activity in patients with MM and CLL has been revealed. Peculiarities of changes functioning in the natural and antibody-dependent killer cells in the disease infectious and haemorrhagic complications have been ascertained. In vivo and in vitro studies showed that cytostatic preparation effect on peripheric blood leukocytes killer activity is directed differently in patients with MM and CLL. Key words: myeloma, chronic lymphocytic leukemia, natural killer cells, antibody-dependent killer cells, cytotoxicity, cytostatic therapy. Oaaeeoey 1 ?ioiieia?/i? iieacieee e aeeioeeo?a e?ia? oai?eo ia i??eiiio oai?iao oa o?ii?/iee e?ioieaeeic a caeaaeiino? a?ae noaae?? caoai?thaaiiy Caei?ia? ethaee Oai?? ia IO Oai?? ia OEE Iieacieee 1-A i?aea?oia 4 a?oia 1-A i?aea?oia 4 a?oia n=20 n=22 n=12 n=11 n=10 IEOe e?ioioeeo?a, % 40,8+3,33 38,45+2,04 10,63+2,2*** 24,9+1,51* 21,32+2,33* ACEOe e?ioioeeo?a, % 33,96+2,6 23,69+2,39* 28,77+4,3 34,51+2,67 7,25+1,3*** IEOe iaeo?io?e?a, % 41,6+3,5 31,84+2,56* 15,12+1,78*** 27,21+2,07* 16,42+2,12*** ACEOe iaeo?io?e?a, % 32,28+1,11 36,78+3,1 13,32+2,66*** 41,49+2,41* 19,4+1,68*** Fc+e?ioioeeo?a, % 33,0+3,07 32,5+1,48 23,66+1,79*** 38,2+2,46 21,6+2,31*** Fc+iaeo?io?ee, % 80,92+1,02 65,5+2,12* 44,0+1,24*** 52,4+1,31* 38,1+3,12*** IgG, a / e 11,63+0,21 38,0+1,56* 64,92+1,8*** 10,12+0,33* 8,42+0,04*** I?ei?oea: * - noaoenoe/ii aeinoia??ia ??cieoey o ii??aiyii? c? caei?iaeie ethaeueie ** - noaoenoe/ii aeinoia??ia ??cieoey i?ae iieacieeaie 1-A i?aea?oie oa 4 a?oie. Oaaeeoey 2 ?ioiieia?/i? iieacieee eaeeioeeo?a e?ia? oai?eo ia i??eiiio oai?iao oa o?ii?/iee e?ioieaeeic c oneeaaeiaiei ia?aa?aii caoai?thaaiue Caei?ia? Eiio?ieueia Oai?? ia IO Oai?? ia OEE Iieacieee ethaee a?oia 1-A i?aea?oia 1-A i?aea?oia 3 a?oia 1-A i?aea?oia 1-A i?aea?oia 3 a?oia n=20 n=20 n=22 n=16 n=12 n=11 n=13 n=10 IEOe e?ioioeeo?a, % 40,8+3,33 39,9+1,42 38,45+2,04 41,39+4,03 46,07+1,1*** 24,9+1,51* 50,85+2,99*** 44,1+3,6*** ACEOe e?ioioeeo?a, % 33,96+2,6 23,8+1,66* 23,69+2,39* 60,45+4,1*** 24,18+1,74* 34,51+2,67 54,6+2,9*** 39,1+3,72 IEOe iaeo?io?e?a, % 41,6+3,5 39,8+2,51 31,84+2,56* 58,5+1,44*** 29,1+2,94* 27,21+2,07* 53,0+1,71*** 38,6+3,18*** ACEOe iaeo?io?e?a, % 32,28+1,11 35,9+2,0 36,78+3,1 55,7+4,14*** 29,1+2,04*** 41,49+2,41* 54,73+3,93*** 32,6+2,84*** Fc+e?ioioeeo?a, % 33,0+3,07 26,5+0,26* 32,5+1,48 36,0+2,31** 32,0+2,84 38,2+2,46 32,57+4,6 24,8+2,41*** Fc+iaeo?io?ee, % 80,92+1,02 85,2+0,45* 65,5+2,12* 67,3+3,42*** 71,5+1,87*** 52,4+1,31* 40,85+3,98*** 76,4+3,37*** IgG, a / e 11,63+0,21 12,83+0,57* 38,0+1,56* 41,6+2,74*** 32,6+2,4* 10,12+0,33* 12,41+0,48 11,9+0,96 I?ei?oea: * - noaoenoe/ii aeinoia??ia ??cieoey o ii??aiyii? c?o caei?iaeie ethaeueie. ** - noaoenoe/ii aeinoia??ia ??cieoey i?ae iieacieeaie 1-A oa eiio?ieueii? a?oie. ***- noaoenoe/ii aeinoia??ia ??cieoey i?ae iieacieeaie 3-? a?oie oa 1-A i?aea?oie. Oaaeeoey 3 ?ioiieia?/i? iieacieee eaeeioeeo?a e?ia? oai?eo ia i??eiiio oai?iao oa o?ii?/iee e?ioieaeeic i?ney oeeoinoaoe/ii? oa?ai?? Caei?ia? ethaee Oai?? ia IO Oai?? ia OEE Iieacieee 1-A i?aea?oia 2-A i?aea?oia 2-A i?aea?oia 1-A i?aea?oia 2-A i?aea?oia 2-A i?aea?oia n=20 n=22 n=15 n=14 n=11 n=13 n=11 IEOe e?ioioeeo?a, % 40,8+3,33 38,45+2,04 16,43+2,12*** 28,51+2,43*** 24,9+1,51* 19,88+2,14* 21,75+2,36* ACEOe e?ioioeeo?a, % 33,96+2,6 23,69+2,39* 24,22+2,39* 21,55+2,11* 34,51+2,67 16,02+1,57*** 21,89+2,92*** IEOe iaeo?io?e?a, % 41,6+3,5 31,84+2,56* 35,33+2,76 15,69+2,16*** 27,21+2,07* 32,76+1,9* 22,07+2,58* ACEOe iaeo?io?e?a, % 32,28+1,11 36,78+3,1 25,66+3,29** 15,3+2,63*** 41,49+2,41* 33,14+2,09** 13,29+2,97*** Fc+e?ioioeeo?a, % 33,0+3,07 32,5+1,48 23,0+2,15*** 21,0+1,74*** 38,2+2,46 48,25+1,25*** 35,2+1,67 Fc+iaeo?io?ee, % 80,92+1,02 65,5+2,12* 76,0+2,16*** 41,3+1,64*** 52,4+1,31* 52,2+2,76* 46,6+2,01*** IgG, a / e 11,63+0,21 38,0+1,56* 33,12+1,91* 28,16+1,72*** 10,12+0,33* 7,16+0,63*** 7,48+0,41*** I?ei?oea: * - noaoenoe/ii aeinoia??ia ??cieoey o ii??aiyii? c?o caei?iaeie ethaeueie. ** - noaoenoe/ii aeinoia??ia ??cieoey a ii??aiyii? c aeaieie 1-A i?aea?oie. 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