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Цитомегаловірусна інфекція у дітей (клініка, діагностика, лікування): Автореф. дис… д-ра мед. наук / Л.А. Ходак, Київ НДІ епідеміології та інфекц. х

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EE?ANUeEEE IAe? AI?AeAI?IEIA?? OA ?IOAEOe?EIEO OAI?IA

?I. E.A. A?IIAOAANUeEIAI IIC OE?A?IE

Ia i?aaao ?oeiieno

OAeE 616.316-022:578.825.12-053.2

OIAeAE Ea?ena Aiaoie??aia

OeEOIIAAAEIA??ONIA ?IOAEOe?ss O Ae?OAE

(EE?I?EA, Ae?AAIINOEEA, E?EOAAIIss)

14.01.13. – ?ioaeoe?ei? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe?y ? ?oeiienii

?iaioa aeeiiaia o Oa?e?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii?
ina?oe

Iaoeiaee eiinoeueoaio:Caneoaeaiee ae?y/ iaoee ? oaoieee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, i?ioani? Aiae?ae/ei Ieoaeei Aioiiiae/, caa. eaoaae?e
?ioaeoe?eieo oai?ia ? ai?aeai?ieia?? Oa?iii?euenei? aea?aeaaii?
iaaee/ii? aeaaeai?? ?i. ?.ss. Ai?aa/aanueeiaiIo?oe?ei? iiiiaioe:aeieoi?
iaaee/ieo iaoe, i?ioani? *a?ieoiaa Ethaeieea ?aai?aia, caa. eaoaae?e
aeeoy/eo ?ioaeoe?eieo oai?ia Ee?anueei? iaaee/ii? aeaaeai??
i?neyaeeieiiii? ina?oe;aeieoi? iaaee/ieo iaoe, i?ioani? I?e?o?i ?aaai
Aaneeueiae/, caa. eaoaae?e ?ioaeoe?eieo oai?ia ? ai?aeai?ieia??
Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoa;aeieoi? iaaee/ieo iaoe,
i?ioani? O??oeiaa E?y Ieaen??aia, i?ioani? eaoaae?e aeeoy/eo
?ioaeoe?eieo oai?ia Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo
?i. I.I. AiaiiieueoeyI?ia?aeia onoaiiaa:Oa?e?anueeee aea?aeaaiee
iaaee/iee oi?aa?neoao

Caoeno a?aeaoaeaoueny ” 23 ” aa?aniy 1999 ?. i 11 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.614.01 Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i. E.A. A?iiaoaanueeiai (2525015, i. Ee?a, aoe. N?/iaaiai iianoaiiy,
23).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai IAe?
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai

Aaoi?aoa?ao ?ic?neaii ” 21 ” na?iiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe

A.Ae. Aiae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oai?iae, ui aeeeeeathoueny a??onaie ?iaeeie
Herpesviridae, oa?aeoa?ecothoueny caaaeueiei ?iciianthaeaeaiiyi,
??ciiiai?oi?noth ee?i?/ieo oi?i ? oeyo?a ia?aaea/? (S. Stagno, 1990;
E.?. *a?ieoiaa, 1998; S. Shiba, 1998; TH.A. Aa?ooaei, 1999). Na?aae ieo
cia/ia i?noea iaeaaeeoue oeeoiiaaaeia??oni?e ?ioaeoe?? (OeIA?).
Oeeoiiaaaeia??onii (OeIA) o ??cieo e?a?iao na?oo ?io?eiaaii a?ae 40 %
aei 100 % aei?ineiai ianaeaiiy (P. Bos et al., 1995; S. Stagno, G.A.
Voud, 1995; A.A. Ne/?a ? ni?aaao., 1998; N.I. Aeaeoie?ia ? ni?aaao.,
1999).

*anoioa aeyaeaiiy OeAI? a inoaii? ?iee /?oei c?inoa?, ui iaoiiaeaii
iie?auaiiyi iaoiae?a eaai?aoi?ii? ae?aaiinoeee, a oaeiae ?noeiiei
ca?eueoaiiyi e?eueeino? ?io?eiaaieo oai?eo oiane?aeie ae?? ??cieo aeci-
oa aiaeiaaiieo oaeoi??a, ye? aeeeeeathoue cieaeaiiy ?ioi?oaoo (S. Chou,
1990; N.A. *aoee, 1995; L. Collier, J. Ixford, 1996).

OeIA? a?aeianaii aei a?oie ?ioaeoe?e, ye? ? ?iaeeeaoi?aie ee?oeiii?
?ioiieia?/ii? iaaeinoaoiino?. Ia?aaeoiiaith aeniei? /anoioe OeIA? ?
o?c?ieia?/ia iaaeinoaoi?noue ?ioi?oaoo a ?aiueiio aeeoy/iio a?oe?,
aaiaoe/i? aeaoaeoe ?ioiii? nenoaie, ?ioiiaeao?oeeoi? noaie aoi?eiiiai
oa?aeoa?o (J.D. Shanley, 1990; I.A. Naiio?i, 1992; S.W. Crawford, 1993;
A.A. Iie?ianueeee, 1996; A.O. Caeeiaa oa ni?aaao., 1998).

OeIA? ? iaei??th c i?e/ei eaoaeueiino? oai?eo ia NI?Ae oa in?a, ye?
caciaee o?ainieaioaoe?? i?aai?a ? oeaiei (H. Balfour, 1991; J.P.
Jaureguiberry, 1991; S.W. Crawford, 1993).

Aeneiaeth?oueny i?eiouaiiy i?i iaoiaaiaoe/io ?ieue OeIA o aeieeiaii? o
ae?oae iaaooeo ?ioiiaeao?oeeoieo noai?a o iinoiaoaeueiiio ia??iae?, ui,
a naith /a?ao, ni?ey? ?icaeoeo aoi?eiii? ?ioaeoe?eii? iaoieia?? (I.A.
Iaiieoeue/einueea, 1995).

OeIA? a?eoea aei neeaaeo TORCH-eiiieaeno ? aaaaea?oueny iae/ano?oith
i?e/eiith ?io?eoaaiiy ieiaeo – a 7 ?ac?a /ano?oith, i?ae a??onii
e?aniooe (P. Griffiths, D. Pillay, 1992). C OeIA? iia’ycai? ieiia?euei?
aeeeaei?, iaaeiiioai?noue, aino?? oa o?ii?/i? ?ioaeoe?? ieiaeo ? ae?oae
?aiiueiai a?eo, i?e?iaeaeai? aaaee ?icaeoeo (C.F. Alford et al., 1990;
S.P. Adler, 1992).

Ui??/ii a?ae 1 % aei 34 % ae?oae ia?iaeaeothoueny c o?iaeaeaiith OeIA?,
aea o?eueee aeecueei 5 % c ieo i?e ia?iaeaeaii? iathoue ee?i?/io
neiioiiaoeeo, ?aooa ia?aiineoue aneiioiiio oeeoiiaaae?th; o aaaaoueio
?icaeaathoueny i?ci? oneeaaeiaiiy, ye? iia’ycai? c o?aaeaiiyi OeIN oa
?ioeo i?aai?a (A.I. Iaoa??a oa ni?aaao., 1992; R. Whiley, 1997; P.
Berge, S. Chiba, 1998).

OeIA? aaaaeathoue iaei??th c iniiaieo iaaaiaoe/ieo i?e/ei, ye?
aecia/athoue noai caei?ia’y iiaiia?iaeaeaieo ? iaa?oue ??aaiue
?ioaeaeooaeueiiai ?icaeoeo iaoe?? (S. Stagno, 1990; C.S. Peckman, 1991).
Oey ?ioaeoe?y ni?ey? ca?eueoaiith e?eueeino? ?iaae?aeeciaaieo ae?oae, ui
? a?ae/ooiith nioe?aeueii-aeiiii?/iith i?iaeaiith (?.A. Aa?oaiyi, 1998).

Oe?iea ?iciianthaeaeaii?noue OeIA?, iiaeeea?noue o?eaaei? ia?nenoaioe??
OeIA a i?aai?ci? ethaeeie c o?aaeaiiyi ??cieo i?aai?a ? nenoai, aeniea
eaoaeuei?noue, o?oaei?noue eaai?aoi?ii? ae?aaiinoeee, a oaeiae
a?aenooi?noue iaae?eieo e?eoaaeueieo ? i?io?eaeoe/ieo cania?a
ia?aeiiothoue a aeooaeueiino? aeaii? i?iaeaie aeey iaoee ? i?aeoeee.

Aeai? e?oa?aoo?e i?i ee?i?/i? i?iyae oa ia?aa?a OeIA? iathoue aaaaoi
noia?a/iinoae. Oae, A.A. Iia?eiaa (1984) aeaco?, ui eieae?ciaaia
oeeoiiaaae?y ? ?acoeueoaoii i?eaeaaii? oi?ie ?ioaeoe??, a aaia?ae?ciaaia
OeIA? o ae?oae a?eii aei 3 i?nyoe?a – iane?aeie i?e?iaeaeaiiai
o?aaeaiiy. Oi/a a?aeiii ?yae eeaneo?eaoe?e OeIA?, caaaeueiiaeciaiiai
a?oioaaiiy ?? ee?i?/ieo oi?i iaia.

Ae?aaiinoeea OeIA? aiane?aeie ??ciiiai?oiino? ee?i?/ieo neiioii?a
aeeeeea? iniaeea? o?oaeiiu?. Ua neeaaei?oa a?aooaaoe ?ieue OeIA? a
iaoieia?/ieo i?ioeanao i?e niieo/aii? ?? c ?ioeie caoai?thaaiiyie.
Oeueiio ieoaiith i?enay/aii aeine?aeaeaiiy ia?aaaaeii ia ii?oieia?/iiio
??ai? (I.A. Naiio?i, 1987; N.Ae. Iiiia, 1993). Aei oeueiai /ano
caeeoathoueny iaaeinoaoiuei aea/aieie ieoaiiy aeeoa?aioe?aeueii?
ae?aaiinoeee ??cieo oi?i OeIA? oa ?o e?eoaaiiy, oiio ui aea??
i?aia?ao?a, ye? iai?aaeaii aieeaathoue ia OeIA, iaiaaeaiee, a o?, ye? ?
a a?naiae?, iaaeinoaoiuei aoaeoeai? ? oaeiae oiene/i?. Ana oea niiioeaei
ian aei iiaeaeueoiai aea/aiiy iaae??oaieo aniaeo?a i?iaeaie OeIA?, aei
iiooeo iaea?eueo aeinooiieo i?aia?ao?a, ye? aeyaeythoue i?e i?i?iaeuei?e
iia?/i?e ae?? ae?aaeaiee i?ioea??oniee oa ?ioiiiiaeoethth/ee aoaeo.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa ? iaeiei c iai?yie?a iaoeiai? ?iaioe eaoaae?e aeeoy/eo
?ioaeoe?eieo oai?ia Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe oa Oa?e?anueeiai IAe? i?e?ia?ieia?? oa ?ioiieia?? ?i. ?.?.
Ia/ieeiaa “Aea/aiiy ?ie? OeIA? a ia?eiaoaeuei?e iaoieia?? oa
caoai?thaaiino? ae?oae ia?oiai ?ieo aeeooy, ?ic?iaea
ee?i?ei-?ioiieia?/ieo oa a??onieia?/ieo e?eoa???a aeey i?aeaeuaiiy
yeino? e?eoaaeueii-ae?aaiinoe/iiai i?ioeano” (oeo? oaie 1 I 5.2.96).

Iaoa aeine?aeaeaiiy. Aeei?enoiaoth/e no/ani? aeniei/ooeea? iaoiaee
eaai?aoi?ii? ae?aaiinoeee, aea/eoe ee?i?ei-iaoiaaiaoe/i? iniaeeaino?
OeIA? oa iie?aueoe ?? aeyaeaiiy o ae?oae; iaa?oiooaaoe oaeoeeo
ao?io?iiii? oa?ai?? oa aecia/eoe ?? aoaeoeai?noue.

Iniiai? caaaeaiiy aeine?aeaeaiiy:

1. Ae?aaiinooaaoe OeIA? o ae?oae ca aeiiiiiaith ee?i?/ieo ? no/anieo
eaai?aoi?ieo iaoiae?a oa aecia/eoe i?noea aeaii? iaoieia?? a ee?i?/i?e
?ioaeoieia??.

2. Ca aeaieie aeooa?nueeiai aiaiiaco iaoa?? aeyaeoe oaeoi?e ?eceeo
?icaeoeo i?e?iaeaeaii? OeIA?.

3. ?ic?iaeoe ee?i?ei-eaai?aoi?i? e?eoa??? ??cieo oi?i OeIA? o ae?oae
??ciiai a?eo.

4. Aeaoaeueii aeine?aeeoe ee?i?/io ea?oeio iaea?eueo cia/eieo i?aaiieo
o?aaeaiue i?e OeIA?.

5. Aea/eoe aieea OeIA? ia ia?aa?a ?ioaeoe?eieo i?ioean?a ?ioi?
ao?ieia??.

6. Aecia/eoe ae?aaiinoe/io oe?ii?noue iia?oi?o niaoeeo?/ieo
eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy.

7. Iaa?oiooaaoe oaeoeeo ao?io?iiii? oa?ai?? i?e OeIA? o ae?oae oa
aea/eoe ?? aoaeoeai?noue.

Iaoeiaa iiaecia ?iaioe. Aia?oa a Oe?a?i? canoiniaaii eiiieaeniee
i?aeo?ae aei aea/aiiy i?iaeaie OeIA? o ae?oae a ee?i?/i?e ?ioaeoieia?? c
canoinoaaiiyi oe?ieiai niaeo?a no/anieo aeniei/ooeeaeo iaoiae?a
eaai?aoi?ii? ae?aaiinoeee. Ia niin?a aecia/aiiy a??ono ca aeiiiiiaith
oeoi?anoeaioiiai ciiaea io?eiaii iaoaio ia aeiao?ae (? 96114276 a?ae
02.06.98 ?.).

Aenoiooi eiioeaioe?th i?i oeeoiiaaae?th ye ?ioaeoe?eio oai?iao. Ia
iniia? aiae?co ee?i?/iiai iaoa??aeo io?eiaii iia? aeai? i?i
oeeoiiaaaeia??oni? o?aaeaiiy OeIN, oeoieiai-eeoeiaiai o?aeoo,
iiiiioeeaiciiiae?aiee neiae?ii i?e OeIA?, ui iiaeeaeth? oyaeaiiy i?i
?ieue OeIA o iaoieia?? o ae?oae. Aeyaeaii, ui OeIA ? iaeiei c
ao?ieia?/ieo oaeoi??a o ?icaeoeo AE? o ae?oae ?aiiueiai a?eo. Aia?oa
aeae?eaii oeeoiiaaaeia??oniee aano?iaioa?ieie?o ye iaeio c ee?i?/ieo
oi?i OeIA?. Cai?iiiiiaaii eeaneoeeaoe?th iniiaieo ee?i?/ieo oi?i OeIA? o
ae?oae oa ?ic?iaeaii ?o ee?i?ei-eaai?aoi?i? e?eoa???.

Aia?oa ai?iaiaaii a?o/eciyiee ?aeiia?iaioiee ?ioa?oa?ii – eaoa?ii i?e
??cieo oi?iao OeIA?, iaa?oioiaaii eiai aoaeoeai?noue, yea caeaaeeoue
a?ae no?ie?a ?io?eoaaiiy OeIA ? nooiaiy o?aaeaiiy ??cieo i?aai?a oa
nenoai.

I?aeoe/ia cia/ei?noue ?iaioe. Ca aeaieie aiae?ca aiaiianoe/ieo aeaieo
i?i ia?aa?a aaa?oiino? oa iieia?a, noaio caei?ia’y iaoa??a ? ae?oae
noi?iiaaii a?oie ?eceeo aioo??oiueioo?iaiiai oa ?io?aiaoaeueiiai
?io?eoaaiiy.

?ic?iaeaii ee?i?ei-eaai?aoi?i? e?eoa??? ??cieo oi?i OeIA?, ye?
o?aoiaothoue iniiai? iaoiaaiaoe/i? aa??aioe oai?iae o ae?oae.

Iieacaii, oi aeei?enoaiiy no/anieo aeniei/ooeeaeo iaoiae?a eaai?aoi?ii?
ae?aaiinoeee (oeeoineii?y, ?OA, AeIE-a?a?eaeecaoe?y) aea? ciiao
nai?/anii aeyaeyoe OeIA? o ae?oae oa aaeaaaoenue aei ?aoe?iiaeueii?
ao?io?iiii? i?ioea??onii? oa?ai??.

Aeey e?eoaaiiy OeIA? cai?iiiiiaaii canoiniaoaaoe i?aia?ao
a-2b-?ioa?oa?iio – eaoa?ii, iieacaii eiai ?ioiiiiaeoethth/o ?
i?ioea??onio ae?th, a?eueo aoaeoeaio, a ii??aiyii? c iaoiaaiaoe/ieie
caniaaie.

Aeey anoaiiaeaiiy ae?aaiico OeIA? ?ic?iaeaii aeai?eoi ianoaaeaiiy
oai?eo, a yeiio ia?aaeaa/aii aecia/aiiy oaeoi??a ?eceeo ?io?eoaaiiy
OeIA, aeeth/ath/e aea/aiiy aeooa?nueeiai aiaiiaco iaoa?? ? aiaiiaco
aeeoeie, a oaeiae aeai? ee?i?/iiai oa niaoeeo?/iiai eaai?aoi?iiai
ianoaaeaiiy.

?ic?iaeai? iaoiaee/i? ?aeiiaiaeaoe?? “Oeeoiiaaaeiae?oniay eioaeoeey o
aeaoae”, ye? caoaa?aeaeaii IIC Oe?a?ie 17.02.99 ?., ? 120/3.

Ioi?ieaii ?aoe?iiae?caoi?nueeo i?iiiceoe?th “Niinia iiaeaioiaee
eioaeoeeiiiiai iaoa?eaea i?e ianeaaeiaaiee ia OeIAE iaoiaeii ?IEO”.
Aeaeaii ?ioi?iaoe?eiee eeno “?aioaaiieia?/ia ae?aaiinoeea ci?i nenoaie
aeeoaiiy i?e OeIA? o ae?oae”.

Iaoa??aee aeena?oaoe?? aeei?enoiaothoueny a eaeoe?yo oa ia i?aeoe/ieo
caiyooyo ia eaoaae?? aeeoy/eo ?ioaeoe?eieo oai?ia Oa?e?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe, Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo oa ia eaoaae?? ?ioaeoe?eieo oai?ia ? eo?n? aeeoy/eo
?ioaeoe?e Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??
?i. ?.ss. Ai?aa/aanueeiai.

Ai?iaiaai? iaoiaee ae?aaiinoeee OeIA? oa ?ic?iaeai? iaoiaee/i?
?aeiiaiaeaoe?? ai?iaaaeaeaii a i?aeoeeo iaeanii? aeeoy/i? ?ioaeoe?eii?
ee?i?/ii? e?ea?i? oa cae?cie/ii? aeeoy/i? e?ea?i? i. Oa?eiaa, iaeanii?
aeeoy/i? e?ea?i? i. *a?i?aiaa oa ?ioaeoe?eii? e?ea?i? i. Iaeane,
?aeiiieo iie?ee?i?e ? 10, 13, 14 i. Oa?eiaa.

Iniaenoee aianie caeiaoaa/a. Aiae?oe/iee iaeyae e?oa?aoo?ieo aeaea?ae,
iiaeeaeai? ee?i?/i? aeine?aeaeaiiy, niinoa?aaeaiiy oai?eo o aeeiai?oe?,
ioi?ieaiiy aeena?oaoe?? cae?eniaii caeiaoaa/ai naiino?eii. Io?eiai?
aeai? caeiaoaa/ noaoenoe/ii ii?aoethaaa oa ?ioa?i?aooaaa, noi?ioethaaa
aeniiaee oa i?aeoe/i? ?aeiiaiaeaoe??, iine?aeiaii ai?iaaaeea ?o o
ee?i?/io i?aeoeeo. ?iaioo aeeiiaii ia aac? IAe?EE i. Oa?eiaa (aieiaiee
e?ea? E.ss. Iaiaeaea).

A??onieia?/i? eaai?aoi?i? aeine?aeaeaiiy i?iaiaeeeenue ni?eueii ?c
ni?a?ia?oieeaie Oa?e?anueeiai IAe? i?e?ia?ieia?? oa ?ioiieia??
?i. ?.?. Ia/ieeiaa (caa?aeoaa/ a??onieia?/ii? eaai?aoi???, aeieoi?
iaaee/ieo iaoe, i?ioani? E.I. Iai/aiei). Aaoi? aeena?oaoe?? aeneiaeth?
aaey/i?noue i?ioani?o E.I. Iai/aiei ca aeiiiiiao i?e aeeiiaii? oe???
/anoeie ?iaioe.

Ai?iaaoe?y ?iaioe. Iniiai? iieiaeaiiy ?iaioe iaaiai?aii a aeiiia?aeyo:
ia iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? ieoaiiy i?e?ia?ieia??,
ai?aeai?ieia?? oa ?ioiieia?? ?ioaeoe?eieo oai?ia” (Oa?e?a, 1993 ?.), ia
can?aeaii? Oa?e?anueeiai iaoeiai-iaaee/iiai oiaa?enoaa aeeoy/eo e?ea??a
(1995-1998 ??.), ia ia?aae? aieiaieo ?ioaeoe?ii?no?a Oe?a?ie (Iieoaaa,
1997 ?.), ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo ? Ieaioiao Anioe?aoe??
?ioaeoe?ii?no?a Oe?a?ie (Noie, 1997 ?.; Ioea/aai, 1997 ?.), ia V c’?cae?
?ioaeoe?ii?no?a Oe?a?ie (Oa?iii?eue, 1998 ?.).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?eii? ?iaioe iioae?eiaaii 35
?ia?o (c ieo 17 aeo?iaeueieo noaoae ? iaeia iiiia?ao?y), aea?
iaoiaee/ieo ?aeiiaiaeaoe??, io?eiaii iaoaio ia aeiao?ae ? 96114276 a?ae
02.06.96 ?.

No?oeoo?a oa ianya aeena?oaoe??. Aei neeaaeo aeena?oaoe?? aoiaeyoue
anooi, iaeyae e?oa?aoo?e, 8 aeaa aeanieo aeine?aeaeaiue, i?aenoiee oa ?o
iaai?aiiy, aeniiaee, i?aeoe/i? ?aeiiaiaeaoe??, nienie e?oa?aoo?e.
Aeena?oaoe?th aeeeaaeaii ia 269 noi??ieao iaoeiiieniiai oaenoo. Nienie
e?oa?aoo?e ia? 317 a?o/eciyieo ? caei?aeiiieo aeaea?ae.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

A ?iaio? i?aaenoaaeaii ?acoeueoaoe ee?i?ei-eaai?aoi?ieo aeine?aeaeaiue
516 oai?eo o a?oe? a?ae 1 i?nyoey aei 12 ?ie?a, ye? iaae?eoee aei IAe?EE
i. Oa?eiaa c ??ciith ?ioaeoe?eiith iaoieia??th. O a?eiaiio a?aeiioaii?
ia?aaaaeaee ae?oe ia?oiai ?ieo aeeooy (86 %).

Ie?aio a?oio neeaee 65 ae?oae c eaoaeueiei iane?aeeii, ye?
aeine?aeaeoaaeenue i?ney nia?o?, oiio an? ee?i?/i? niinoa?aaeaiiy
i?aaenoaaeaii ca ?acoeueoaoaie aeine?aeaeaiiy 451 oai?iai (oaae. 1).

Oaaeeoey 1

?iciiae?e oai?eo caeaaeii a?ae ae?aaiico i?e iaaeoiaeaeaii? aei ee?i?ee

Na?aae ianoaaeaieo aoei 256 (56,8 %) oeii/ee?a ? 195 (43,2 %)
ae?a/aoie. An?o ae?oae aoei aeine?aeaeaii ia ia?ea?e OeIA? c?
canoinoaaiiyi oaeeo iaoiae?a:

1) oeeoineii?y inaaeea neeie, na/?, e?eai?a ca iaoiaeii A.I. *a?iiai
(1972) aeey aeyaeaiiy oeeoiiaaaeia??onieo ee?oei (OeIE);

2) aecia/aiiy niaoeeo?/ieo aei OeIA ?ioiiaeiaoe?i?a eean?a M ? G.
No?iee ?io?eoaaiiy anoaiiaethaaee ca aeiiiiiaith aeyaeaiiy ?iaeaena
aa?aeiino? aioeo?e aei aioeaaia, yeee aei??yee o i?ioeaioao (o??ia
“A?ina?a?n”, i. Iineaa);

3) aecia/aiiy AeIE-OeIA ca aeiiiiiaith iaoiaeo NIIO-a?a?eaeecaoe??
(oano-nenoaia “Aaeoi?-OeIA-AeIE”, i. Iiainea??nuee);

4) aecia/aiiy aioeaaio OeIA ca aeiiiiiaith ?aaeoe?? iai?yii?
?ioiioeoi?anoeaioe?? (?I?O);

5) aecia/aiiy a??ono a ?ioaeoe?eiiio iaoa??ae? ca aeiiiiiaith
oeoi?anoeaioiiai ciiaea (OC) – io?eiaii iaoaio (? 96114276 a?ae
02.06.98 ?.).

O ieai? aeeoa?aioe?aeueii? ae?aaiinoeee i?iaiaeeeenue aeine?aeaeaiiy ia
aa?ian ? oieniieaciic.

Iaeii/anii ?c niaoeeo?/ieie aeine?aeaeaiiyie ia ia?ea?e OeIA? aea/aee
iieacieee ia?eoa?e/ii? e?ia?, i?ioa?iia?aie, eii?ia?aie. ?ioiieia?/ia
aeine?aeaeaiiy neeaaeaeinue c aecia/aiiy e?euee?nieo iieaciee?a
ee?oeiiiai ?ioi?oaoo (O-e?ioioeeo?a oa ?o iniiaieo noaiiioeyoe?e ?c
canoinoaaiiyi iiiieeiiaeueieo aioeo?e) ? aoii?aeueii? eaiee ?ioi?oaoo c
aecia/aiiyi ??aiy Ig A, M, G ca iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a
aae? (Mancini, 1969).

I?ae /an niinoa?aaeaiiy oai?eo c iaa?ieia?/iith neiioiiaoeeith
i?iaiaeeee ?ino?oiaioaeuei? aeine?aeaeaiiy: aoiaioeaoaeineii?th,
iae?iniiia?ao?th, a aeey e?ioeaai? ioe?iee no?oeoo?ieo ci?i ia?aio?ie
iiceo oa eiai ii?iaeieiieo nenoai aeei?enoiaoaaee iaai?oii-?aciiainio
oiiia?ao?th iiceo (I?O). Aeine?aeaeaiiy i?iaiaeeee ca aeiiiiiaith
oeueo?acaoeiaiai neaia?a – 628A ? iaai?oii-?aciiainiiai oiiia?aoa
“Ia?ac-1”.

Iaea?aeai? ?acoeueoaoe noaoenoe/ii ia?iaeaii ia IBM-?N-486 DX4-100 c
aeei?enoaiiyi iaoiae?a aa??aoe?eii? noaoenoeee ca e?eoa??yie No’thaeaioa
oa Iaiia-O?oi?. Noaoenoe/ii cia/eieie aaaaeaee aeai? c ??aiai
a??ia?aeiino? p0,05), oiae? ye a?iio?io?y 2-ai nooiaiy a 2,5 ?ace /ano?oa
con??/aeanue a iniiai?e a?oi?, i?ae o eiio?ieuei?e (63,9 % ? 26,3 %,
?0,05). Iaeiae cieaeaiiy ai?noo aaiaaeiaoe?i?a aoei a?eueoa ae?aaeaia
a ?io?eiaaieo OeIA (7,02±0,53 % ? 9,08±0,48 %, ?0,05).

Eiiieaenia oa?ai?y c aeei?enoaiiyi eaoa?iio iaea ?ioiiiiaeoethth/ee
aieea ia ee?oeiio eaieo ?ioi?oaoo, i?aeaeuoth/e iecuee? oa iiieaeath/e
aenie? iieacieee, ii?iae?coth/e ni?aa?aeiioaiiy e?eueeino? noaiiioeyoe?e
e?ioioeeo?a, i?e oeueiio iaea?eueo aeoeaiei aoa c??no ??aiy O-oaeia??a
(29,0±1,1 % ? 38,5±1,3 % a?aeiia?aeii, ?0,05). O ai?no? ne?iaaoeiaeo ?ioiiaeiaoe?i?a
iniiaieo eean?a ia aeyaeaii nooo?aeo ci?i.

Aoaeoeai?noue i?aia?aoo aaaaoi a /iio caeaaeaea a?ae no?ie?a
?io?eoaaiiy aeeoeie. Aiia aoea iaeiaioith i?e ?aiiueiio ?io?eoaaii?
ieiaeo, oiaoi i?e aioo??oiueioo?iai?e ?ioaeoe??. O ca’yceo c oeei ie
aeae?eeee oaeoi?e, ye? aieeaathoue ia aoaeoeai?noue eaoa?iiioa?ai??
(noaia 2).

Aoaeoeai?noue oa?ai?? i?e OeIA? a a?eueoino? aeiaaee?a aecia/aeanue
no?ieii ?? ii/aoeo. Ine?eueee ia?o? ee?i?/i? neiioiie caoai?thaaiiy
iiaeooue i?iyaeoeny i?ney ia?iaeaeaiiy ia a?ae?aco, a ia 2-4-io i?nyoe?
aeeooy, an?o iiaiia?iaeaeaieo c iani?eyoeeaei i?aii?a?aeiei oiiii ?
iani?eyoeeaei aeooa?nueeei aiaiiacii iaoa??a, iaiao?aeii ianoaaeeoe ia
a?oio o?ainieaoeaioa?ieo ?ioaeoe?e, o oiio /ene? OeIA?, uia yeiiiaa
?ai?oa ?icii/aoe eiiieaenio, niaoeeo?/io oa?ai?th ?c canoinoaaiiyi
i?ioea??onieo i?aia?ao?a.

Ae?oyi c ee?i?/ieie neiioiiaie OeIA? iieacaii i?ecia/aiiy i?ioea??onii?
oa?ai?? ?c canoinoaaiiyi eaoa?iio a ii?aeiaii? c a??ieaenii. Ae?oyi,
?io?eiaaiei OeIA aac ee?i?/ieo i?iya?a, aea c eiai eaai?aoi?iei
i?aeoaa?aeaeaiiyi aeoeaiino? ?ioaeoe?eiiai i?ioeano, iaiao?aeii
i?iaiaeeoe e?eoaaiiy c aeei?enoaiiyi ?ioiiiiaeoethth/iai caniao, iaeiei
c yeeo iiaea aooe eaoa?ii.

Iani?eyoeeaee aieea ?io?eoaaiiy OeIA ia ia?aa?a ?ioaeoe?eii? iaoieia??
o ae?oae i?aeoaa?aeaeoaaany oaeiae aeaieie ?noi??e oai?iae ?
iaoiii?oieia?/ieo aeine?aeaeaiue 65 ae?oae a?eii a?ae 1 i?nyoey aei 1
?ieo 2 i?nyoe?a, ye? iiia?ee a IAe?EE i. Oa?eiaa i?ioyaii 1992-1996 ??.
Na?aae iiia?eeo ia?aaaaeaee ae?oe ia?oeo 3 i?nyoe?a aeeooy – 32 aeeoeie
(49,2 %).

I?e aeeoo? ia OeIA? aaeaeiny ianoaaeeoe 18 ae?oae. O 11 c ieo aeyaeaii
OeIE: a inaaeeao neeie oa na/? – o 2-o, o?eueee a neei? – o 3-o, o?eueee
a na/? – o 6 oai?eo. Niaoeeo?/i? aioeoeeoiiaaaeia??oni? aioeo?ea
aeyaeaii o 5 ae?oae. I?e ioi?ieaii? caeeth/iiai ee?i?/iiai ae?aaiico
o?eueee o 2 oai?eo OeIA? aeciaii iniiaiei caoai?thaaiiyi, o 11 – ye
noiooith iaoieia?th. I?ae oei, i?e iaoieiaiaiioii?/ieo aeine?aeaeaiiyo o
33 ae?oae ciaeaeaii ii?oieia?/i? ci?ie a ??cieo i?aaiao, ye? aeacothoue
ia OeIA?, aea ?o iaiiaeeeai iiynieoe o?eueee iniiaiei caoai?thaaiiyi
(iai?ia?o, eeoeiaa ?ioaeoe?y).

Ii?yae c oeei o 15 ae?oae oe??? a?oie a eaaaiyo ? o 8 ae?oae a ?ioeo
i?aaiao ciaeaeaii e?ioia?no?ioeeoa?i? ?io?eueo?aoe, ?iiae? c
i??ei?aeieie ee?oeiaie, ui iiaei aooe coiiaeaii ae??th AeIE-a??on?a,
cie?aia OeIA.

AENIIAEE

1. Ae?oe, ye? ia?iaeeeenue a?ae iaoa??a c iani?eyoeeaei ia?aa?aii
aaa?oiino? oa iieia?a (aeeeaei? a ieioeiio, oieneeice oa caa?ica
ia?a?eaaiiy aaa?oiino?, ia?aae/ani? iieiae), oi?iothoue a?oio ?eceeo
aioo??oiueioo?iaiiai oa ?io?aiaoaeueiiai ?io?eoaaiiy OeIA.

2. O ae?oae, ye? ciaoiaeeeenue o Oa?e?anuee?e iaeani?e aeeoy/?e
?ioaeoe?ei?e ee?i?/i?e e?ea?i?, ?io?eiaai?noue OeIA i?e iayaiino?
iaa?ieia?/ii? neiioiiaoeee neeaea 39,8 %, o?aaeaiiy oeoieiai-eeoeiaiai
o?aeoo – 51,5 %, iiiiioeeaiciiiae?aii? oi?ie caoai?thaaiiy – 8,7 %.

3. O ae?oae c aioo??oiueioo?iaiith OeIA?, ia a?aei?io a?ae
iinoiaoaeueii?, niinoa??aaeenue a?iio?io?y 1-3-ai nooiaiy, ??ci?
o?aaeaiiy OeIN (a?ae neiae?iio i?eai?/aiiy ?? aei ?icaeoeo
oeeoiiaaaeia??oniiai iai?iaiaioeaoae?oo), aiai?y, o?iiaioeeoiiai?y.

4. Ia i?aenoaa? aeaieo ee?i?/ieo aeine?aeaeaiue ? aeniei/ooeeaeo
niaoeeo?/ieo iaoiae?a eaai?aoi?ii? ae?aaiinoeee (oeeoineii?y, ?OA,
AeIE-a?a?eaeecaoe?y) aeae?eaii ee?i?ei-iaoiaaiaoe/i? oi?ie OeIA?:
aino?a, o?ii?/ia, ?aaeoeaiaaia, noaee?i?/ia (eaoaioia).

5. Aioo??oiueioo?iaia o?aaeaiiy OeIN, yea aoei ae?aaiinoiaaii o 27,7 %
ae?oae ?c a?oie ?eceeo, iae/ano?oa aeyaeyeinue cao?eieith ineoiiioi?iiai
?icaeoeo (92,3 %), a?ia?oaic?eii-a?ae?ioeaoaeueiei (80,8 %) ? noaeiiiei
(69,2 %) neiae?iiaie. O a?eueoino? oai?eo (80,8 %) iaee i?noea
noi?iiaai? i?aai?/i? o?aaeaiiy (?icoe?aiiy oeoii/eiai? nenoaie iiceo,
ia?aaaio?eeoey?i? e?noe, aiaioeaoae?y). I?ia?aeieie a ioe?ioe?
no?oeoo?ieo ci?i ia?aio?ie iiceo ? eiai ii?iaeieiieo nenoai aoee
oeueo?acaoeiaa ae?aaiinoeea ? I?O aieiaiiai iiceo.

6. Iaeiei c i?iya?a aeoeaii? OeIA? o ae?oae ?aiiueiai a?eo ? noaeiiiee
neiae?ii, yeee niinoa??aaany o 27,2 % oai?eo. Anoaiiaeaii ei?aeyoe?eio
caeaaei?noue i?ae aeyaeaiiyi OeIE a inaaeeao neeie oa iayai?noth
noaeiiiiai neiae?iio.

7. O oai?eo, ?io?eiaaieo OeIA, c o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo a
30,3 % aeiaaee?a OeIA? ia?aa?aaea o aeaeyae? iiii?ioaeoe?? ? aoea
ao?ieia?/iei oaeoi?ii aano?iaioa?ieie?oo, o 58 % oai?eo – ye
i?eno-?ioaeoe?y, iaoyaeoth/a ia?aa?a AE?, oa a 11,7 % niinoa?aaeaiue
ae?aaiinoiaaii noaee?i?/io oi?io OeIA?, yea ia ia? ae?aaeaiiai aieeao ia
iniiaia caoai?thaaiiy.

8. I?e iiiiioeeaiciiiae?ai?e oi?i? OeIA?, ia a?aei?io a?ae ?ioaeoe?eiiai
iiiiioeeaico, oiicee?o ? e?ioaaeaiiiao?y aoee ae?aaeai? a iacia/i?e
i???, a iiiioeeoico ia aeyaeaii. Oey oi?ia ?ioaeoe?? iaea aino?ee
ia?aa?a aai o?ii?/iee c ianooiiith ?aaeoeaaoe??th OeIA.

9. Aiae?c ?aioaaiia?ai i?aai?a a?oaeii? ee?oee aeicaieea o a?eueoino?
oai?eo ia OeIA? (97,1 %) aeyaeoe caaaa/aiiy ? iineeaiiy eaaaiaaiai
iaethiea – aeaia?/ia oa aeeoocia, a?eueo ae?aaeaia a iaae?aeueieo
a?aeae?eao, ci?ie ei?ai?a eaaaiue (o 37,1 %), aiaieuaa? iiaaiii??
??ciiai nooiaiy ae?aaeaiiy (o 60 %), aoaeaeoace (o 37,1 %). Ci?iaiee
eaaaiaaee iaethiie caa??aaany i?ioyaii i?nyoey i?ney ia?aianaiiai
caoai?thaaiiy.

10.  C o?aooaaiiyi aiaiianoe/ieo, ee?i?/ieo ? ii?oieia?/ieo aeaieo o
ae?oae, ye? iiia?ee a?ae ?ioaeoe?eii? iaoieia??, ?aaeueia /anoioa OeIA?
(51 %) aeyaeeanue aeuith, i?ae aecia/aeanue o ee?i?/i?e i?aeoeoe? (20
%).

11.  Iaea?eueo aeinooiiei oa ?ioi?iaoeaiei o ae?aaiinoeoe? OeIA? ?
oeeoineii?/iee iaoiae aeine?aeaeaiiy. Eiai /ooeea?noue neeaea 75 %,
niaoeeo?/i?noue – 93 %, a??ia?aei?noue – 84 %.

12.  Anoaiiaeoe caeeth/iee ae?aaiic OeIA? iiaeia ia i?aenoaa? iiceoeaieo
?acoeueoao?a ia iaioa ye aeaio iaoiae?a eaai?aoi?ii? ae?aaiinoeee:
oeeoineii?y + ?OA aai ?OA + AeIE-a?a?eaeecaoe?y. Aeniei?ioi?iaoeaiei
oanoii, yeee aeicaiey? aeyaeoe noaee?i?/io oi?io OeIA?, ? iaoiae
AeIE-a?a?eaeecaoe??.

13.  Onoaiiaeaii oa?aiaaoe/io aoaeoeai?noue eaoa?iio i?e OeIA? o ae?oae,
yea i?iyaeyeanue ciaioaiiyi ai?y/eiaiai ia??iaeo, oaeaeoith
ii?iae?caoe??th aeii?iaeiaiue, i?aeaeuaiiyi iieaciee?a aaiiaeia?io ?
o?iiaioeeo?a. I?aia?ao ni?eya ii?iae?caoe?? ni?aa?aeiioaiiy
noaiiioeyoe?e O-e?ioioeeo?a o e?ia?, i?aeaeuoth/e /enei O-oaeia??a.
Aoaeoeai?noue eaoa?iio caeaaeaea a?ae nooiaiy ?iciianthaeaeaiino?
?ioaeoe?eiiai i?ioeano ? no?ie?a ?io?eoaaiiy aeeoeie, oa aoea iaeiaioith
o ?ac? aioo??oiueioo?iaiiai ?io?eoaaiiy.

Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??

1. Oiaeae E.A., Iaaao O.E. ?ieue oeeoiiaaaeee a no?oeoo?a eaoaeueiinoe
aiieiuo iaieiaeoia o aeaoae ?aiiaai aic?anoa // Aanoiee i?iaeai
nia?aiaiiie iaaeeoeeiu. – 1995. – ? 4. – N. 128-131.

2. Oiaeae E.A., Iaa?o O.?., Ni?eyinueea I.A., Iaea?aiei A.Ae. Ei?/? o
ae?oae ?aiiueiai a?eo ye i?iya oeeoiiaaaeia??onii? ?ioaeoe?? a
aeieia?/ii iani?eyoeeaeo oiiaao // Iaae?ao??y, aeooa?noai oa
a?iaeieia?y. – 1996. – ? 3. – N. 19-21.

3. Oiaeae E.A., Iaaao O.E. A?iaeaeaiiay oeeoiiaaaeiae?oniay eioaeoeey n
ii?aaeaieai aieiaiiai iicaa o ?aaaiea 5 ianyoeaa // Iaaeeao?ey. – 1997.
– ? 3. – N. 101-102.

4. Oiaeae E.A. Oeeoiiaaaeiae?oniay eioaeoeey o aeaoae // Oa?ueeianeee
iaae. aeo?iae. – 1997. – ? 1. – N. 44-47.

5. Oiaeae E.A., Ni?eyinueea I.A., Ia?aiio N.Ae., Iai/aiei E.I. E?eoaaiiy
oeeoiiaaaeia??onii? ?ioaeoe?? o ae?oae // ?ioaeoe?ei? oai?iae. – 1997. –
? 3. – N. 51-52.

6. Oiaeae E.A. No/ani? iiaeyaee ia aa?iana??oni? ?ioaeoe??
// ?ioaeoe?ei? oai?iae. – 1997. – ? 4. – N. 42-44.

7. Oiaeae E.A. Oa?iaeioa?aiey aa?ianae?oniuo eioaeoeee
// Iaaeaeoia?iaeiue iaae. aeo?iae. – 1997. – ? 4. – N. 57-59.

8. E?aiiee ?.I., Oiaeae E.A., Ai?oiee I.I., A?ea E.I.
Ee?i?ei-?aioaaiieia?/i? i?iyae ci?i eaaaiue i?e oeeoiiaaaeia??oni?e
?ioaeoe?? o ae?oae ?aiiueiai a?eo // Oe?a?inueeee ?aae?ieia?/iee
aeo?iae. – 1998. – ? 1. – N. 27-29.

9. Oiaeae E.A. Nia?aiaiiua aniaeou oeeoiiaaaeiae?oniie eioaeoeee o
aeaoae // Oe?a?inueeee a?niee ineoiiaa?ieia???. – 1997. – o.5 aei. 3
(15). – N. 115-116.

10.  Oiaeae E.A. Oeueo?acaoeiaa aeine?aeaeaiiy oa iaai?oii-?aciiainia
oiiia?ao?y o?aaeaiue aieiaiiai iiceo i?e oeeoiiaaaeia??oni?e ?ioaeoe?? o
ae?oae // Oe?a?inueeee ?aae?ieia?/iee aeo?iae. – 1998. – ? 3. –
N. 269-271.

11.  Oiaeae E.A. Iiiiioeeaiciiiaeiaiay oi?ia oeeoiiaaaeiae?oniie
eioaeoeee o ?aaaiea ?aiiaai aic?anoa // Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu. – 1998. – ? 21. – N. 74-75.

12. Iai/aiei E.A., Oiaeae E.A., Iiiiaa E.A., A?aaa?ue A.A. Iiiaieeeee
aa?ian: nia?aiaiiua aeaiiua i eeeieei-ii?oieiae/aneii iieeii?oecia.
Ne?eieia aioeaaiia aa?ianae?onia 1 e 2 oeiia o aieueiuo ?acee/iiai
i?ioeey // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. – 1998. – ? 15. –
N. 37-40.

13.  Oiaeae E.A., Aiae?ae/ei I.A., Iai/aiei E.I., Ee?e/aiei ?.?.
Iiaeeeaino? eaai?aoi?ii? ae?aaiinoeee OeIA? // ?ioaeoe?ei? oai?iae. –
1998. – ? 4. – N. 47-51.

14.  Oiaeae E.A., Iaa?o O.?., E?aia??a N.I. Oeeoiiaaaeia??onia ?ioaeoe?y
o ae?oae // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. – 1998. – ? 4. –
N. 47-50.

15.  Oiaeae E.A. Ii?aaeaiea oeaio?aeueiie ia?aiie nenoaiu i?e
oeeoiiaaaeiae?oniie eioaeoeee o aeaoae // Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu. -1999. – ? 7. – N. 60-63.

16.  Iai/aiei E.A., Ee?e/aiei E.E., Eo/ia E.TH., Oiaeae E.A. N?aaenoaa
oa?aiee e i?ioeeaeoeee aa?ianae?oniuo eioaeoeee. – Oa?ueeia: ?EI
“I?eaeiae”, 1999. – 90 n.

17.  Iai/aiei E.A., Oiaeae E.A., Ee?e/aiei E.E. Aicaoaeeoaee
aa?ianae?oniuo eioaeoeee e iaeaieaa aaaeiua eeeie/aneea i?iyaeaiey o
/aeiaaea // I?iaeci?. – 1999. – ? 10. – N. 28-29.

18.  Oiaeae E.A., Iai/aiei E.I., Ee?e/aiei ?.?. Aaiii-?iaeaia?iee
aeueoa-2-?aeiia?iaioiee ?ioa?oa?ii o eiiieaeniiio e?eoaaii?
oeeoiiaaaeia??onii? ?ioaeoe?? // Ee?i?/ia oa?iaoe?y. – 1999. – ?  2. –
N. 102-104.

19.  Oiaeae E.A. Nia?aiaiiua i?aaenoaaeaiey i oeeoiiaaaeiae?oniie
eioaeoeee o aeaoae // Iaoa?eaeu thaeeaeiie eiioa?aioeee, iinayuaiiie
75-eaoeth eaoaae?u eioaeoeeiiiuo aieaciae OEOA, i?eeiaeaiea e “School of
Fundamental Medicine Journal”, March 1999, Vol.5, ?1, P.105-106.

20.  Oiaeae E.A. Oeeoiiaaaeey a eioaeoeeiiiie iaoieiaee o aeaoae // ??
iaoeeiiaeueiue eiia?ann aianoaceieiaia Oe?aeiu: Oac. aeiee. – Oa?ueeia,
1996. – N. 110.

21.  Oiaeae E.A., Iaaao O.E., Niaeyineay I.A. Eeeieei-eaai?aoi?iua
aniaeou oeeoiiaaaeiae?oniie eioaeoeee o aeaoae ?aiiaai aic?anoa // Eaeae
E.E. Ia/ieeiaa e ?acaeoea nia?aiaiiiai anoanoaiciaiey: Iaoa?eaeu
iaaeaeoia?iaeiie iao/iie eiioa?aioeee. – Oa?ueeia. – 1995. – N. 331-332.

22.  Oiaeae E.A., Iaea?aiei A.Ae. OeIA? a no?oeoo?? aino?eo
aano?iaioa?ieie?o?a o ae?oae ia?oiai i?a?ieo aeeooy // 13-e c’?cae
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a,
ia?aceoieia?a: Oac. aeii. – A?iieoey. – 1996. – N. 79.

23.  Oiaeae E.A., Iaa?o O.E., Iaea?aiei A.Ae., Ni?eyinueea I.A.
Oeeoiiaaaei-a??onia ?ioaeoe?y o ae?oae // 13-e c’?cae Oe?a?inueeiai
iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a, ia?aceoieia?a: Oac.
aeii. – A?iieoey. – 1996. – N. 304-305.

24.  Oiaeae E.A., Iaa?o O.E. Aea/aiiy ?iciianthaeaeaiino? OeIA? na?aae
oai?eo iai?ia?oii a ?aiiueiio aeeoy/iio a?oe? // 13-e c’?cae
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a,
ia?aceoieia?a: Oac. aeii. – A?iieoey. – 1996. – N. 274.

25.  Oiaeae E.A., Niaeyineay I.A., Iai/aiei E.I., Eo/ia E.TH.
Yooaeoeaiinoue eaai?aoi?iie aeeaaiinoeee OeIAE o aeaiuei n ioyaiuaiiui
aeooa?neei aiaiiacii // Eaeae E.E. Ia/ieeiaa e ?acaeoea nia?aiaiiiai
anoanoaiciaiey: Iaoa?eaeu iaaeaeoia?iaeiie iao/iie eiioa?aioeee.. –
Oa?ueeia. – 1995. – N. 279-280.

26.  Oiaeae E.A., Iai/aiei E.I., Iaa?o O.?. Oeeoiiaaaeia??onia
?ioaeoe?y: iiaeeeaino? ae?aaiinoeee e?eoaaiiy ia no/aniiio aoai? // 5-e
c’?cae ?ioaeoe?ii?no?a a Oe?a?i?: Oac. aeii. – Oa?iii?eue, 1998. –
N. 347-348.

27.  Oiaeae E.A., Ni?eyinueea I.A. Ioe?iea niaoeeo?/ieo iaoiae?a
eaai?aoi?ii? ae?aaiinoeee OeIA? o ae?oae // Iao. iaoe.-i?aeo. eiio. –
Noie – Oa?iii?eue. – 1997. – N. 32-35.

28.  Oiaeae E.A., Iaea?aiei A.Ae. Iniaaiiinoe eeeie/aneiai oa/aiey
ino?uo eeoa/iuo eioaeoeee o aeaoae ia?aiai aiaea aeecie // Iiaia a
iaaeeoeeia: Nai?iee iao/iuo o?oaeia. – Oa?ueeia, 1994. – N. 80.

29.  Oiaeae E.A., Iaea?aiei E.E., ?uaaeei A.I., Cae?aaneee I.I.
Iniaaiiinoe oa?aiee eioaeoeeiiiuo aieueiuo a iino?aaieiaoeeiiiii
ia?eiaea // Iaaeeoeeia. Yenia?eiaio. I?aeoeea: na. iao/. noaoae. –
Oa?ueeia, 1994. – N. 119-121.

30.  Oiaeae E.A., Iaea?aiei E.E., ?uaaeei A.I., Cae?aaneee I.I.
Iniaaiiinoe eeeie/aneiai oa/aiey oeeoiiaaaeee o aeaoae //  Aeooaeueiua
aii?inu iee?iaeieiaee, yieaeaieieiaee e eiioiieiaee eioaeoeeiiiuo
aieaciae: Oac. aeiee. iao/.-i?aeo. eiio. – Oa?ueeia, 1993. – N. 228.

31.  Oiaeae E.A. I?ioeeaeoe/aneea aniaeou oeeoiiaaaeiae?oniie eioeoeee
// Aeieiae/aneia aeaenoaea oaeoi?ia ie?oaeathuae n?aaeu: Na. iao/.
o?oaeia. – Oa?ueeia, 1996. – N. 123-124.

32.  Oiaeae E.A., Iaea?aiei E.E., Oeoiiiaa E.A., E?e/aaneay A.TH.
Cia/aiea OeIAE a ?acaeoee noaei?iaeiiai neiae?iia o aeaoae
// Iee?iaeieiaey, yieaeaieieiaey e eeeieea eioaeoeeiiiuo aieaciae: Na.
iao/. noaoae. – Oa?ueeia, 1993. – N. 85-88.

33.  Oiaeae E.A., Aeaeaeaeia Y.A., Oeoiiiaa E.A. Ninoiyiea
oiieieeoa/iiai ieuaaa?aiey i?e OeIAE o aeaoae // Iee?iaeieiaey,
yieaeaieieiaey e eeeieea eioaeoeeiiiuo aieaciae: Na. iao/. noaoae. –
Oa?ueeia, 1993. – N. 88-91.

34.  Oiaeae E.A., Aeaeaeaeia Y.A., Iaea?aiei E.E. Eiaeiua i?iyaeaiey i?e
OeIAE o aeaoae // Nia?aiaiiua aniaeou aeeaaiinoeee, eeeieee e
i?ioeeaeoeee eiaeiuo, aaia?e/aneeo e ae?oaeo eioaeoeeiiiuo caaieaaaiee
(NIEAe): Oac. aeiee. iao/.-i?aeo. eiio. – Oa?ueeia, 1991. – N. 61.

35.  Oiaeae E.A., Aeaeaeaeia Y.A., Iaea?aiei E.E. Ia?ooaiea ooieoeee
aeaeoaei/ii-eeoa/iiai o?aeoa e eo ei??aeoeey i?e o?iie/aneie OeIAE o
aeaoae // O?iie/aneia ainiaeaiea e caaieaaaiey i?aaiia ieuaaa?aiey:
Iaoa?eaeu iao/i.-i?aeo. eiio. – Oa?ueeia, 1991. – N. 158.

Aiioaoe?y

Oiaeae E.A. Oeeoiiaaaeia??onia ?ioaeoe?y o ae?oae (ee?i?ea,
ae?aaiinoeea, e?eoaaiiy). – ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca
niaoe?aeuei?noth 14.01.13 – ?ioaeoe?ei? oai?iae. Iaoeiai-aeine?aeiee
?inoeooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai,
Ee?a, 1999.

Iaoith ?iaioe aoei aeine?aeeoe ee?i?ei-iaoiaaiaoe/i? iniaeeaino? OeIA?
o ae?oae, iie?aueoe ?? ae?aaiinoeeo oa ?ic?iaeoe iioeiaeueio oaeoeeo
ao?ieia?/ii? oa?ai??. I?ae niinoa?aaeaiiyi aoei 516 oai?eo a?eii a?ae 1
i?nyoey aei 12 ?ie?a. Aia?oa aeaii ee?i?/io ioe?ieo canoinoaaiiy
iaoiae?a oeeoineii??, ?OA ? AeIE-a?a?eaeecaoe?? aeey ae?aaiinoeee OeIA?
o ae?oae. Iieacaii aenieo ?ioi?iaoeai?noue iaoiaeo AeIE-a?a?eaeecaoe??
oa eiai ni?iiiaei?noue aeyaeyoe noaee?i?/io oi?io OeIA?.

Anoaiiaeaii, ui ?io?eiaai?noue OeIA oai?eo c iaa?ieia?/iith
neiioiiaoeeith noaiiaeea 39,8 %, o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo –
51,5 %, iiiiioeeaiciiiae?aiith oi?iith caoai?thaaiiy – 8,7 %. Aeae?eaii
?yae ee?i?ei-iaoiaaiaoe/ieo oi?i OeIA?: aino?o, o?ii?/io, ?aaeoeaiaaio ?
noaee?i?/io (eaoaioio). Aecia/aii ee?i?/i? i?iyae a?iaeaeaiiai o?aaeaiiy
OeIN ? no?oeoo?i? ci?ie aieiaiiai iiceo (ca aeaieie iaai?oii-?aciiainii?
oiiia?ao??), ca’ycie noaeii ?c OeIA.

Ia i?aenoaa? eiiieaeniiai aeine?aeaeaiiy oai?eo ?c ee?i?/iith ea?oeiith
AE? aia?oa aeyaeaii aano?iaioa?ieie?oio oi?io OeIA? oa iienaii ??
ee?i?/i? i?iyae, aea/aii iniaeeaino? ii?aeiaiiy OeIA? c AE?.
Aeine?aeaeaii ee?i?/i? oa ?aioaaiieia?/i? iniaeeaino? o?aaeaiiy eaaaiue
i?e OeIA?, eiinoaioiaaii caa?aaeaiiy ci?iaiiai iaethiea oeueiai i?aaia o
?aeiiaaeanoeaio?a.

Aia?oa iaa?oioiaaii oa?aiaaoe/io aoaeoeai?noue eaoa?iio i?e OeIA? o
ae?oae, eiai i?ioea??onio oa ?ioiiiiaeoethth/o ae?th.

Eeth/ia? neiaa: oeeoiiaaaeia??onia ?ioaeoe?y, ee?i?/i? i?iyae,
ae?aaiinoeea, e?eoaaiiy.

Aiiioaoeey

Oiaeae E.A. Oeeoiiaaaeiae?oniay eioaeoeey o aeaoae (eeeieea,
aeeaaiinoeea, ea/aiea). – ?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie aeieoi?a iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.13 – eioaeoeeiiiua aieacie.
Iao/ii-enneaaeiaaoaeueneee einoeooo aieaeaieieiaee e eioaeoeeiiiuo
aieaciae ei. E.A. A?iiaoaaneiai, Eeaa, 1999.

Oeaeueth ?aaiou yaeeinue eco/aiea eeeieei-iaoiaaiaoe/aneeo iniaaiiinoae
OeIAE o aeaoae, oeo/oaiea aa aeeaaiinoeee e ?ac?aaioea iioeiaeueiie
oaeoeee yoeio?iiiie oa?aiee. Iiae iaaethaeaieai iaoiaeeeinue 516
aieueiuo a aic?anoa io 1 ianyoea aei 12 eao. Aia?aua aeaia eeeie/aneay
ioeaiea i?eiaiaiiuo iaoiaeia oeeoineiiee, EOA, AeIE-aea?eaeecaoeee aeey
aeeaaiinoeee OeIAE o aeaoae. Iieacaia aunieay eioi?iaoeaiinoue iaoiaea
AeIE-aea?eaeecaoeee e aai aiciiaeiinoue auyaeyoue noaeeeie/aneoth oi?io
OeIAE.

Onoaiiaeaii, /oi eioaoee?iaaiiinoue OeIA aieueiuo n iaa?ieiae/aneie
neiioiiaoeeie ninoaaeea 39,8 %, ii?aaeaieai aeaeoaei/ii-eeoa/iiai o?aeoa
– 51,5 %, iiiiioeeaiciiiaeiaiie oi?iie caaieaaaiey – 8,7 %. Auaeaeaiu
eeeieei-iaoiaaiaoe/aneea oi?iu OeIAE: ino?ay, o?iie/aneay,
?aaeoeae?iaaiiay e noaeeeie/aneay (eaoaioiay). Ii?aaeaeaiu eeeie/aneea
i?iyaeaiey aioo?eoo?iaiiai ii?aaeaiey OeIN e no?oeoo?iua eciaiaiey
aieiaiiai iicaa (ii aeaiiui iaaieoii-?aciiainiie oiiia?aoee),
acaeiinaycue noaei?iaeiiai neiae?iia n OeIA.

Ia iniiaaiee eiiieaeniiai ianeaaeiaaiey aieueiuo n eeeie/aneie ea?oeiie
IEE aia?aua auyaeaia aano?iyioa?ieieeoe/aneay oi?ia OeIAE e iienaiu aa
eeeie/aneea i?iyaeaiey, eco/aiu iniaaiiinoe ni/aoaiiiai oa/aiey OeIAE e
IEE. Enneaaeiaaiu eeeie/aneea e ?aioaaiieiae/aneea iniaaiiinoe
ii?aaeaiey eaaeeo i?e OeIAE, onoaiiaeaii nio?aiaiea eciaiaiiiai
eaai/iiai ?enoiea o ?aeiiaaeanoeaioia.

Aia?aua ii?aaeaeaia oa?aiaaoe/aneay yooaeoeaiinoue eaoa?iia i?e OeIAE o
aeaoae, aai i?ioeaiae?oniia e eiioiiiiaeoee?othuaa aeaenoaea.

Eeth/aaua neiaa: oeeoiiaaaeiae?oniay eioaeoeey, eeeie/aneea i?iyaeaiey,
aeeaaiinoeea, ea/aiea.

Annotation

L.A. Khodak. Cytomegalovirus Infections in Children (clinic,
diagnostics, treatment). – Manuscript.

Thesis for academic deqree of doctor of Science (Medicine) in Specialty
14.01.13 – infections diseases. L.V. Gromashevsky – Scientific Research
Institute of Epidemiology and infections disease, Ministry of Health of
Ukraine, Kiev, 1999.

The object of this work is studying of clinical and patogenetical
particularities of CMVI in children, improving its diagnostics and
working out optimum tactics of ethiothropic therapy.

516 patients from 1 mouth to 12 years old were observed.

Clinical estimation of applicated methods, such as: cytoscopy,
immunological fermental analysis and deoxyribonucleic acid gibridization
(DNA) for diagnostics of CMVI in children was represented for the first
time.

High informativity of DNA-gibridization and its possibilities to
indicate the subclinical form of CMVI was observed.

For improving the informativity of specific methods of laboratory
diagnostics and estimation of the activity of infection process, the
simultenions use of not less than two methods of laboratory diagnostics
was recommended. It was determined that the infectioning of CMVI
patients with neurological symptoms was 39,8 %, with the damage of
alimentary canal – 51,5 % and with mononucleosis from of CMVI – 8,7 %.

Clinical pathogenetic forms of CMVI were distinguished. They are: acute,
chronical, reactivative and subclinical (latentive) one.

Clinical manifestations of congenital damage of CNS and structural
changes in the brain (according to the data of MRT) were estimated.
Interconnection between convulsive syndrome and presence of CMV was
described.

Clinical properties of acute intestine infection were studied in
children with CMV.

In clinical investigation first was estimated gastroenterocolitic from
of CMVI. Here we could observe the combined course of CMVI and acute
intestinal infections that caused more prolonged and intensive clinical
symptoms and worsening of the prognosis of the disease.

Clinical and x-ray particularities of damage of the lungs in CMVI were
investigated. Conservation of changed lung image in reconvalescents was
estimated.

Differential diagnosis between infection mononucleosis and similar to
mononucleosis form CMVI was carried out. It was estimated that for form
similar to the mononucleosis one is the absence of tonsillitis and
monocytosis in blood. Limphadenopathy is expressed insignificantly. The
final diagnosis is possible to the exposed markers of CMV.

First it was determined the therapeutically effectiveness of laferon
in CMVI in children, its antivirus and immunomodulating activity.

Rational scheme of use of this preparation in combination with
pathogenetic therapy was proposed.

For early diagnostics of CMVI in children, the algorithm of examination
of patients was worked out.

Key words: cytomegalovirus infection, clinical manifestations,
diagnostics, treatment.

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