EE?ANUeEEE IAe? AI?AeAI?IEIA?? OA ?IOAEOe?EIEO OAI?IA

?I. E.A. A?IIAOAANUeEIAI IIC OE?A?IE

Ia i?aaao ?oeiieno

OAeE 616.316-022:578.825.12-053.2

OIAeAE Ea?ena Aiaoie??aia

OeEOIIAAAEIA??ONIA ?IOAEOe?ss O Ae?OAE

(EE?I?EA, Ae?AAIINOEEA, E?EOAAIIss)

14.01.13. — ?ioaeoe?ei? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe?y ? ?oeiienii

?iaioa aeeiiaia o Oa?e?anuee?e iaaee/i?e aeaaeai?? i?neyaeeieiiii?
ina?oe

Iaoeiaee eiinoeueoaio:Caneoaeaiee ae?y/ iaoee ? oaoieee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, i?ioani? Aiae?ae/ei Ieoaeei Aioiiiae/, caa. eaoaae?e
?ioaeoe?eieo oai?ia ? ai?aeai?ieia?? Oa?iii?euenei? aea?aeaaii?
iaaee/ii? aeaaeai?? ?i. ?.ss. Ai?aa/aanueeiaiIo?oe?ei? iiiiaioe:aeieoi?
iaaee/ieo iaoe, i?ioani? *a?ieoiaa Ethaeieea ?aai?aia, caa. eaoaae?e
aeeoy/eo ?ioaeoe?eieo oai?ia Ee?anueei? iaaee/ii? aeaaeai??
i?neyaeeieiiii? ina?oe;aeieoi? iaaee/ieo iaoe, i?ioani? I?e?o?i ?aaai
Aaneeueiae/, caa. eaoaae?e ?ioaeoe?eieo oai?ia ? ai?aeai?ieia??
Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoa;aeieoi? iaaee/ieo iaoe,
i?ioani? O??oeiaa E?y Ieaen??aia, i?ioani? eaoaae?e aeeoy/eo
?ioaeoe?eieo oai?ia Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo
?i. I.I. AiaiiieueoeyI?ia?aeia onoaiiaa:Oa?e?anueeee aea?aeaaiee
iaaee/iee oi?aa?neoao

Caoeno a?aeaoaeaoueny » 23 » aa?aniy 1999 ?. i 11 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.614.01 Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia
?i. E.A. A?iiaoaanueeiai (2525015, i. Ee?a, aoe. N?/iaaiai iianoaiiy,
23).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueeiai IAe?
ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai

Aaoi?aoa?ao ?ic?neaii » 21 » na?iiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe

A.Ae. Aiae

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oai?iae, ui aeeeeeathoueny a??onaie ?iaeeie
Herpesviridae, oa?aeoa?ecothoueny caaaeueiei ?iciianthaeaeaiiyi,
??ciiiai?oi?noth ee?i?/ieo oi?i ? oeyo?a ia?aaea/? (S. Stagno, 1990;
E.?. *a?ieoiaa, 1998; S. Shiba, 1998; TH.A. Aa?ooaei, 1999). Na?aae ieo
cia/ia i?noea iaeaaeeoue oeeoiiaaaeia??oni?e ?ioaeoe?? (OeIA?).
Oeeoiiaaaeia??onii (OeIA) o ??cieo e?a?iao na?oo ?io?eiaaii a?ae 40 %
aei 100 % aei?ineiai ianaeaiiy (P. Bos et al., 1995; S. Stagno, G.A.
Voud, 1995; A.A. Ne/?a ? ni?aaao., 1998; N.I. Aeaeoie?ia ? ni?aaao.,
1999).

*anoioa aeyaeaiiy OeAI? a inoaii? ?iee /?oei c?inoa?, ui iaoiiaeaii
iie?auaiiyi iaoiae?a eaai?aoi?ii? ae?aaiinoeee, a oaeiae ?noeiiei
ca?eueoaiiyi e?eueeino? ?io?eiaaieo oai?eo oiane?aeie ae?? ??cieo aeci-
oa aiaeiaaiieo oaeoi??a, ye? aeeeeeathoue cieaeaiiy ?ioi?oaoo (S. Chou,
1990; N.A. *aoee, 1995; L. Collier, J. Ixford, 1996).

OeIA? a?aeianaii aei a?oie ?ioaeoe?e, ye? ? ?iaeeeaoi?aie ee?oeiii?
?ioiieia?/ii? iaaeinoaoiino?. Ia?aaeoiiaith aeniei? /anoioe OeIA? ?
o?c?ieia?/ia iaaeinoaoi?noue ?ioi?oaoo a ?aiueiio aeeoy/iio a?oe?,
aaiaoe/i? aeaoaeoe ?ioiii? nenoaie, ?ioiiaeao?oeeoi? noaie aoi?eiiiai
oa?aeoa?o (J.D. Shanley, 1990; I.A. Naiio?i, 1992; S.W. Crawford, 1993;
A.A. Iie?ianueeee, 1996; A.O. Caeeiaa oa ni?aaao., 1998).

OeIA? ? iaei??th c i?e/ei eaoaeueiino? oai?eo ia NI?Ae oa in?a, ye?
caciaee o?ainieaioaoe?? i?aai?a ? oeaiei (H. Balfour, 1991; J.P.
Jaureguiberry, 1991; S.W. Crawford, 1993).

Aeneiaeth?oueny i?eiouaiiy i?i iaoiaaiaoe/io ?ieue OeIA o aeieeiaii? o
ae?oae iaaooeo ?ioiiaeao?oeeoieo noai?a o iinoiaoaeueiiio ia??iae?, ui,
a naith /a?ao, ni?ey? ?icaeoeo aoi?eiii? ?ioaeoe?eii? iaoieia?? (I.A.
Iaiieoeue/einueea, 1995).

OeIA? a?eoea aei neeaaeo TORCH-eiiieaeno ? aaaaea?oueny iae/ano?oith
i?e/eiith ?io?eoaaiiy ieiaeo – a 7 ?ac?a /ano?oith, i?ae a??onii
e?aniooe (P. Griffiths, D. Pillay, 1992). C OeIA? iia’ycai? ieiia?euei?
aeeeaei?, iaaeiiioai?noue, aino?? oa o?ii?/i? ?ioaeoe?? ieiaeo ? ae?oae
?aiiueiai a?eo, i?e?iaeaeai? aaaee ?icaeoeo (C.F. Alford et al., 1990;
S.P. Adler, 1992).

Ui??/ii a?ae 1 % aei 34 % ae?oae ia?iaeaeothoueny c o?iaeaeaiith OeIA?,
aea o?eueee aeecueei 5 % c ieo i?e ia?iaeaeaii? iathoue ee?i?/io
neiioiiaoeeo, ?aooa ia?aiineoue aneiioiiio oeeoiiaaae?th; o aaaaoueio
?icaeaathoueny i?ci? oneeaaeiaiiy, ye? iia’ycai? c o?aaeaiiyi OeIN oa
?ioeo i?aai?a (A.I. Iaoa??a oa ni?aaao., 1992; R. Whiley, 1997; P.
Berge, S. Chiba, 1998).

OeIA? aaaaeathoue iaei??th c iniiaieo iaaaiaoe/ieo i?e/ei, ye?
aecia/athoue noai caei?ia’y iiaiia?iaeaeaieo ? iaa?oue ??aaiue
?ioaeaeooaeueiiai ?icaeoeo iaoe?? (S. Stagno, 1990; C.S. Peckman, 1991).
Oey ?ioaeoe?y ni?ey? ca?eueoaiith e?eueeino? ?iaae?aeeciaaieo ae?oae, ui
? a?ae/ooiith nioe?aeueii-aeiiii?/iith i?iaeaiith (?.A. Aa?oaiyi, 1998).

Oe?iea ?iciianthaeaeaii?noue OeIA?, iiaeeea?noue o?eaaei? ia?nenoaioe??
OeIA a i?aai?ci? ethaeeie c o?aaeaiiyi ??cieo i?aai?a ? nenoai, aeniea
eaoaeuei?noue, o?oaei?noue eaai?aoi?ii? ae?aaiinoeee, a oaeiae
a?aenooi?noue iaae?eieo e?eoaaeueieo ? i?io?eaeoe/ieo cania?a
ia?aeiiothoue a aeooaeueiino? aeaii? i?iaeaie aeey iaoee ? i?aeoeee.

Aeai? e?oa?aoo?e i?i ee?i?/i? i?iyae oa ia?aa?a OeIA? iathoue aaaaoi
noia?a/iinoae. Oae, A.A. Iia?eiaa (1984) aeaco?, ui eieae?ciaaia
oeeoiiaaae?y ? ?acoeueoaoii i?eaeaaii? oi?ie ?ioaeoe??, a aaia?ae?ciaaia
OeIA? o ae?oae a?eii aei 3 i?nyoe?a – iane?aeie i?e?iaeaeaiiai
o?aaeaiiy. Oi/a a?aeiii ?yae eeaneo?eaoe?e OeIA?, caaaeueiiaeciaiiai
a?oioaaiiy ?? ee?i?/ieo oi?i iaia.

Ae?aaiinoeea OeIA? aiane?aeie ??ciiiai?oiino? ee?i?/ieo neiioii?a
aeeeeea? iniaeea? o?oaeiiu?. Ua neeaaei?oa a?aooaaoe ?ieue OeIA? a
iaoieia?/ieo i?ioeanao i?e niieo/aii? ?? c ?ioeie caoai?thaaiiyie.
Oeueiio ieoaiith i?enay/aii aeine?aeaeaiiy ia?aaaaeii ia ii?oieia?/iiio
??ai? (I.A. Naiio?i, 1987; N.Ae. Iiiia, 1993). Aei oeueiai /ano
caeeoathoueny iaaeinoaoiuei aea/aieie ieoaiiy aeeoa?aioe?aeueii?
ae?aaiinoeee ??cieo oi?i OeIA? oa ?o e?eoaaiiy, oiio ui aea??
i?aia?ao?a, ye? iai?aaeaii aieeaathoue ia OeIA, iaiaaeaiee, a o?, ye? ?
a a?naiae?, iaaeinoaoiuei aoaeoeai? ? oaeiae oiene/i?. Ana oea niiioeaei
ian aei iiaeaeueoiai aea/aiiy iaae??oaieo aniaeo?a i?iaeaie OeIA?, aei
iiooeo iaea?eueo aeinooiieo i?aia?ao?a, ye? aeyaeythoue i?e i?i?iaeuei?e
iia?/i?e ae?? ae?aaeaiee i?ioea??oniee oa ?ioiiiiaeoethth/ee aoaeo.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa ? iaeiei c iai?yie?a iaoeiai? ?iaioe eaoaae?e aeeoy/eo
?ioaeoe?eieo oai?ia Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe oa Oa?e?anueeiai IAe? i?e?ia?ieia?? oa ?ioiieia?? ?i. ?.?.
Ia/ieeiaa “Aea/aiiy ?ie? OeIA? a ia?eiaoaeuei?e iaoieia?? oa
caoai?thaaiino? ae?oae ia?oiai ?ieo aeeooy, ?ic?iaea
ee?i?ei-?ioiieia?/ieo oa a??onieia?/ieo e?eoa???a aeey i?aeaeuaiiy
yeino? e?eoaaeueii-ae?aaiinoe/iiai i?ioeano” (oeo? oaie 1 I 5.2.96).

Iaoa aeine?aeaeaiiy. Aeei?enoiaoth/e no/ani? aeniei/ooeea? iaoiaee
eaai?aoi?ii? ae?aaiinoeee, aea/eoe ee?i?ei-iaoiaaiaoe/i? iniaeeaino?
OeIA? oa iie?aueoe ?? aeyaeaiiy o ae?oae; iaa?oiooaaoe oaeoeeo
ao?io?iiii? oa?ai?? oa aecia/eoe ?? aoaeoeai?noue.

Iniiai? caaaeaiiy aeine?aeaeaiiy:

1. Ae?aaiinooaaoe OeIA? o ae?oae ca aeiiiiiaith ee?i?/ieo ? no/anieo
eaai?aoi?ieo iaoiae?a oa aecia/eoe i?noea aeaii? iaoieia?? a ee?i?/i?e
?ioaeoieia??.

2. Ca aeaieie aeooa?nueeiai aiaiiaco iaoa?? aeyaeoe oaeoi?e ?eceeo
?icaeoeo i?e?iaeaeaii? OeIA?.

3. ?ic?iaeoe ee?i?ei-eaai?aoi?i? e?eoa??? ??cieo oi?i OeIA? o ae?oae
??ciiai a?eo.

4. Aeaoaeueii aeine?aeeoe ee?i?/io ea?oeio iaea?eueo cia/eieo i?aaiieo
o?aaeaiue i?e OeIA?.

5. Aea/eoe aieea OeIA? ia ia?aa?a ?ioaeoe?eieo i?ioean?a ?ioi?
ao?ieia??.

6. Aecia/eoe ae?aaiinoe/io oe?ii?noue iia?oi?o niaoeeo?/ieo
eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy.

7. Iaa?oiooaaoe oaeoeeo ao?io?iiii? oa?ai?? i?e OeIA? o ae?oae oa
aea/eoe ?? aoaeoeai?noue.

Iaoeiaa iiaecia ?iaioe. Aia?oa a Oe?a?i? canoiniaaii eiiieaeniee
i?aeo?ae aei aea/aiiy i?iaeaie OeIA? o ae?oae a ee?i?/i?e ?ioaeoieia?? c
canoinoaaiiyi oe?ieiai niaeo?a no/anieo aeniei/ooeeaeo iaoiae?a
eaai?aoi?ii? ae?aaiinoeee. Ia niin?a aecia/aiiy a??ono ca aeiiiiiaith
oeoi?anoeaioiiai ciiaea io?eiaii iaoaio ia aeiao?ae (? 96114276 a?ae
02.06.98 ?.).

Aenoiooi eiioeaioe?th i?i oeeoiiaaae?th ye ?ioaeoe?eio oai?iao. Ia
iniia? aiae?co ee?i?/iiai iaoa??aeo io?eiaii iia? aeai? i?i
oeeoiiaaaeia??oni? o?aaeaiiy OeIN, oeoieiai-eeoeiaiai o?aeoo,
iiiiioeeaiciiiae?aiee neiae?ii i?e OeIA?, ui iiaeeaeth? oyaeaiiy i?i
?ieue OeIA o iaoieia?? o ae?oae. Aeyaeaii, ui OeIA ? iaeiei c
ao?ieia?/ieo oaeoi??a o ?icaeoeo AE? o ae?oae ?aiiueiai a?eo. Aia?oa
aeae?eaii oeeoiiaaaeia??oniee aano?iaioa?ieie?o ye iaeio c ee?i?/ieo
oi?i OeIA?. Cai?iiiiiaaii eeaneoeeaoe?th iniiaieo ee?i?/ieo oi?i OeIA? o
ae?oae oa ?ic?iaeaii ?o ee?i?ei-eaai?aoi?i? e?eoa???.

Aia?oa ai?iaiaaii a?o/eciyiee ?aeiia?iaioiee ?ioa?oa?ii – eaoa?ii i?e
??cieo oi?iao OeIA?, iaa?oioiaaii eiai aoaeoeai?noue, yea caeaaeeoue
a?ae no?ie?a ?io?eoaaiiy OeIA ? nooiaiy o?aaeaiiy ??cieo i?aai?a oa
nenoai.

I?aeoe/ia cia/ei?noue ?iaioe. Ca aeaieie aiae?ca aiaiianoe/ieo aeaieo
i?i ia?aa?a aaa?oiino? oa iieia?a, noaio caei?ia’y iaoa??a ? ae?oae
noi?iiaaii a?oie ?eceeo aioo??oiueioo?iaiiai oa ?io?aiaoaeueiiai
?io?eoaaiiy.

?ic?iaeaii ee?i?ei-eaai?aoi?i? e?eoa??? ??cieo oi?i OeIA?, ye?
o?aoiaothoue iniiai? iaoiaaiaoe/i? aa??aioe oai?iae o ae?oae.

Iieacaii, oi aeei?enoaiiy no/anieo aeniei/ooeeaeo iaoiae?a eaai?aoi?ii?
ae?aaiinoeee (oeeoineii?y, ?OA, AeIE-a?a?eaeecaoe?y) aea? ciiao
nai?/anii aeyaeyoe OeIA? o ae?oae oa aaeaaaoenue aei ?aoe?iiaeueii?
ao?io?iiii? i?ioea??onii? oa?ai??.

Aeey e?eoaaiiy OeIA? cai?iiiiiaaii canoiniaoaaoe i?aia?ao
a-2b-?ioa?oa?iio – eaoa?ii, iieacaii eiai ?ioiiiiaeoethth/o ?
i?ioea??onio ae?th, a?eueo aoaeoeaio, a ii??aiyii? c iaoiaaiaoe/ieie
caniaaie.

Aeey anoaiiaeaiiy ae?aaiico OeIA? ?ic?iaeaii aeai?eoi ianoaaeaiiy
oai?eo, a yeiio ia?aaeaa/aii aecia/aiiy oaeoi??a ?eceeo ?io?eoaaiiy
OeIA, aeeth/ath/e aea/aiiy aeooa?nueeiai aiaiiaco iaoa?? ? aiaiiaco
aeeoeie, a oaeiae aeai? ee?i?/iiai oa niaoeeo?/iiai eaai?aoi?iiai
ianoaaeaiiy.

?ic?iaeai? iaoiaee/i? ?aeiiaiaeaoe?? “Oeeoiiaaaeiae?oniay eioaeoeey o
aeaoae”, ye? caoaa?aeaeaii IIC Oe?a?ie 17.02.99 ?., ? 120/3.

Ioi?ieaii ?aoe?iiae?caoi?nueeo i?iiiceoe?th “Niinia iiaeaioiaee
eioaeoeeiiiiai iaoa?eaea i?e ianeaaeiaaiee ia OeIAE iaoiaeii ?IEO”.
Aeaeaii ?ioi?iaoe?eiee eeno “?aioaaiieia?/ia ae?aaiinoeea ci?i nenoaie
aeeoaiiy i?e OeIA? o ae?oae”.

Iaoa??aee aeena?oaoe?? aeei?enoiaothoueny a eaeoe?yo oa ia i?aeoe/ieo
caiyooyo ia eaoaae?? aeeoy/eo ?ioaeoe?eieo oai?ia Oa?e?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe, Oa?e?anueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo oa ia eaoaae?? ?ioaeoe?eieo oai?ia ? eo?n? aeeoy/eo
?ioaeoe?e Oa?iii?euenueei? aea?aeaaii? iaaee/ii? aeaaeai??
?i. ?.ss. Ai?aa/aanueeiai.

Ai?iaiaai? iaoiaee ae?aaiinoeee OeIA? oa ?ic?iaeai? iaoiaee/i?
?aeiiaiaeaoe?? ai?iaaaeaeaii a i?aeoeeo iaeanii? aeeoy/i? ?ioaeoe?eii?
ee?i?/ii? e?ea?i? oa cae?cie/ii? aeeoy/i? e?ea?i? i. Oa?eiaa, iaeanii?
aeeoy/i? e?ea?i? i. *a?i?aiaa oa ?ioaeoe?eii? e?ea?i? i. Iaeane,
?aeiiieo iie?ee?i?e ? 10, 13, 14 i. Oa?eiaa.

Iniaenoee aianie caeiaoaa/a. Aiae?oe/iee iaeyae e?oa?aoo?ieo aeaea?ae,
iiaeeaeai? ee?i?/i? aeine?aeaeaiiy, niinoa?aaeaiiy oai?eo o aeeiai?oe?,
ioi?ieaiiy aeena?oaoe?? cae?eniaii caeiaoaa/ai naiino?eii. Io?eiai?
aeai? caeiaoaa/ noaoenoe/ii ii?aoethaaa oa ?ioa?i?aooaaa, noi?ioethaaa
aeniiaee oa i?aeoe/i? ?aeiiaiaeaoe??, iine?aeiaii ai?iaaaeea ?o o
ee?i?/io i?aeoeeo. ?iaioo aeeiiaii ia aac? IAe?EE i. Oa?eiaa (aieiaiee
e?ea? E.ss. Iaiaeaea).

A??onieia?/i? eaai?aoi?i? aeine?aeaeaiiy i?iaiaeeeenue ni?eueii ?c
ni?a?ia?oieeaie Oa?e?anueeiai IAe? i?e?ia?ieia?? oa ?ioiieia??
?i. ?.?. Ia/ieeiaa (caa?aeoaa/ a??onieia?/ii? eaai?aoi???, aeieoi?
iaaee/ieo iaoe, i?ioani? E.I. Iai/aiei). Aaoi? aeena?oaoe?? aeneiaeth?
aaey/i?noue i?ioani?o E.I. Iai/aiei ca aeiiiiiao i?e aeeiiaii? oe???
/anoeie ?iaioe.

Ai?iaaoe?y ?iaioe. Iniiai? iieiaeaiiy ?iaioe iaaiai?aii a aeiiia?aeyo:
ia iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeooaeuei? ieoaiiy i?e?ia?ieia??,
ai?aeai?ieia?? oa ?ioiieia?? ?ioaeoe?eieo oai?ia” (Oa?e?a, 1993 ?.), ia
can?aeaii? Oa?e?anueeiai iaoeiai-iaaee/iiai oiaa?enoaa aeeoy/eo e?ea??a
(1995-1998 ??.), ia ia?aae? aieiaieo ?ioaeoe?ii?no?a Oe?a?ie (Iieoaaa,
1997 ?.), ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo ? Ieaioiao Anioe?aoe??
?ioaeoe?ii?no?a Oe?a?ie (Noie, 1997 ?.; Ioea/aai, 1997 ?.), ia V c’?cae?
?ioaeoe?ii?no?a Oe?a?ie (Oa?iii?eue, 1998 ?.).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?eii? ?iaioe iioae?eiaaii 35
?ia?o (c ieo 17 aeo?iaeueieo noaoae ? iaeia iiiia?ao?y), aea?
iaoiaee/ieo ?aeiiaiaeaoe??, io?eiaii iaoaio ia aeiao?ae ? 96114276 a?ae
02.06.96 ?.

No?oeoo?a oa ianya aeena?oaoe??. Aei neeaaeo aeena?oaoe?? aoiaeyoue
anooi, iaeyae e?oa?aoo?e, 8 aeaa aeanieo aeine?aeaeaiue, i?aenoiee oa ?o
iaai?aiiy, aeniiaee, i?aeoe/i? ?aeiiaiaeaoe??, nienie e?oa?aoo?e.
Aeena?oaoe?th aeeeaaeaii ia 269 noi??ieao iaoeiiieniiai oaenoo. Nienie
e?oa?aoo?e ia? 317 a?o/eciyieo ? caei?aeiiieo aeaea?ae.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy

A ?iaio? i?aaenoaaeaii ?acoeueoaoe ee?i?ei-eaai?aoi?ieo aeine?aeaeaiue
516 oai?eo o a?oe? a?ae 1 i?nyoey aei 12 ?ie?a, ye? iaae?eoee aei IAe?EE
i. Oa?eiaa c ??ciith ?ioaeoe?eiith iaoieia??th. O a?eiaiio a?aeiioaii?
ia?aaaaeaee ae?oe ia?oiai ?ieo aeeooy (86 %).

Ie?aio a?oio neeaee 65 ae?oae c eaoaeueiei iane?aeeii, ye?
aeine?aeaeoaaeenue i?ney nia?o?, oiio an? ee?i?/i? niinoa?aaeaiiy
i?aaenoaaeaii ca ?acoeueoaoaie aeine?aeaeaiiy 451 oai?iai (oaae. 1).

Oaaeeoey 1

?iciiae?e oai?eo caeaaeii a?ae ae?aaiico i?e iaaeoiaeaeaii? aei ee?i?ee

Na?aae ianoaaeaieo aoei 256 (56,8 %) oeii/ee?a ? 195 (43,2 %)
ae?a/aoie. An?o ae?oae aoei aeine?aeaeaii ia ia?ea?e OeIA? c?
canoinoaaiiyi oaeeo iaoiae?a:

1) oeeoineii?y inaaeea neeie, na/?, e?eai?a ca iaoiaeii A.I. *a?iiai
(1972) aeey aeyaeaiiy oeeoiiaaaeia??onieo ee?oei (OeIE);

2) aecia/aiiy niaoeeo?/ieo aei OeIA ?ioiiaeiaoe?i?a eean?a M ? G.
No?iee ?io?eoaaiiy anoaiiaethaaee ca aeiiiiiaith aeyaeaiiy ?iaeaena
aa?aeiino? aioeo?e aei aioeaaia, yeee aei??yee o i?ioeaioao (o??ia
“A?ina?a?n”, i. Iineaa);

3) aecia/aiiy AeIE-OeIA ca aeiiiiiaith iaoiaeo NIIO-a?a?eaeecaoe??
(oano-nenoaia “Aaeoi?-OeIA-AeIE”, i. Iiainea??nuee);

4) aecia/aiiy aioeaaio OeIA ca aeiiiiiaith ?aaeoe?? iai?yii?
?ioiioeoi?anoeaioe?? (?I?O);

5) aecia/aiiy a??ono a ?ioaeoe?eiiio iaoa??ae? ca aeiiiiiaith
oeoi?anoeaioiiai ciiaea (OC) – io?eiaii iaoaio (? 96114276 a?ae
02.06.98 ?.).

O ieai? aeeoa?aioe?aeueii? ae?aaiinoeee i?iaiaeeeenue aeine?aeaeaiiy ia
aa?ian ? oieniieaciic.

Iaeii/anii ?c niaoeeo?/ieie aeine?aeaeaiiyie ia ia?ea?e OeIA? aea/aee
iieacieee ia?eoa?e/ii? e?ia?, i?ioa?iia?aie, eii?ia?aie. ?ioiieia?/ia
aeine?aeaeaiiy neeaaeaeinue c aecia/aiiy e?euee?nieo iieaciee?a
ee?oeiiiai ?ioi?oaoo (O-e?ioioeeo?a oa ?o iniiaieo noaiiioeyoe?e ?c
canoinoaaiiyi iiiieeiiaeueieo aioeo?e) ? aoii?aeueii? eaiee ?ioi?oaoo c
aecia/aiiyi ??aiy Ig A, M, G ca iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a
aae? (Mancini, 1969).

I?ae /an niinoa?aaeaiiy oai?eo c iaa?ieia?/iith neiioiiaoeeith
i?iaiaeeee ?ino?oiaioaeuei? aeine?aeaeaiiy: aoiaioeaoaeineii?th,
iae?iniiia?ao?th, a aeey e?ioeaai? ioe?iee no?oeoo?ieo ci?i ia?aio?ie
iiceo oa eiai ii?iaeieiieo nenoai aeei?enoiaoaaee iaai?oii-?aciiainio
oiiia?ao?th iiceo (I?O). Aeine?aeaeaiiy i?iaiaeeee ca aeiiiiiaith
oeueo?acaoeiaiai neaia?a – 628A ? iaai?oii-?aciiainiiai oiiia?aoa
“Ia?ac-1”.

Iaea?aeai? ?acoeueoaoe noaoenoe/ii ia?iaeaii ia IBM-?N-486 DX4-100 c
aeei?enoaiiyi iaoiae?a aa??aoe?eii? noaoenoeee ca e?eoa??yie No’thaeaioa
oa Iaiia-O?oi?. Noaoenoe/ii cia/eieie aaaaeaee aeai? c ??aiai
a??ia?aeiino? p<0,05. ?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy Ca aeaieie niaoeeo?/ieo aeine?aeaeaiue ia ia?ea?e OeIA? c 451 oai?iai ?io?eiaaiei OeIA, aeyaeeenue 240 ae?oae, c ieo o 9 io?eiaii oeaiiiiceoeai? ?acoeueoaoe, aiie ia aa?eoee i? a iaeio c a?oi niinoa?aaeaiue. Oiio iniiaio a?oio neeaa 231 oai?ee, a eiio?ieueio – 211. Iiceoeai? ?acoeueoaoe aeei?enoaiiy oeeoineii?/iiai iaoiaeo iaea?aeaii o 183 oai?eo (40,6 %) (oaae. 2). O a?eueoino? aeiaaee?a (71,5 %) OeIE aecia/ai? o?eueee o na/? aai a neei? oa iaeii/anii. Oaaeeoey 2 *anoioa aeyaeaiiy ia?ea??a OeIA? o oai?eo Ca aeiiiiiaith oeeoineii?/iiai iaoiaeo ia?aeaeueii c ae?oueie, aoei ianoaaeaii 116 iaoa??a, ye iiaeeeaa aeaea?aei ?io?eoaaiiy. O 61 iaoa?? (52,6 %) aoei aeyaeaii niaoeeo?/i? ee?oeie ye o na/?, oae ? a neei?. Oa, ui o ?aooe iaoa??a ia aoei ciaeaeaii OeIE iiaeia iiynieoe oeeoiiaaae?/iith o?ainoi?iaoe??th ee?oei a ?ioeo i?aaiao aai a?aenooi?noth ?io?eoaaiiy. Iaoiaeii ?OA aeey aeyaeaiiy aioeoeeoiiaaaeia??onieo aioeo?e c ??ciei nooiaiai aa?aeiino? ianoaaeaii 411 ae?oae. Iiceoeai? ?acoeueoaoe aeyaeaii o 225 (54,7 %) oai?eo. Iecueeee iieaciee eiaeaeno aa?aeiino? (iaioa 35 %) oeacoaaa ia ia?aeiio OeIA? aai ?? aino?ee ia?aa?a, ? a?aei?/aany o 109 ae?oae (48,4 %). Aenieee ?iaeaen (a?eueoa 42 %) /ano?oa cana?ae/oaaa i?i o?ii?/iee i?ioean, a iieaciee aa?aeiino? 36-41 %, yeee aeyaeaii o 30 (13,3 %) oai?eo, i?aeoaa?aeaeoaaa i?cith noaae?th ia?aeiiiai ?io?eoaaiiy aai ?aaeoeaaoe?th OeIA. Aeey i?aeoaa?aeaeaiiy OeIA? aecia/aee aaiii a??onii? AeIE iaoiaeii iieaeoey?ii? a?a?eaeecaoe??. C? 162 ianoaaeaieo ?acoeueoaoe aeyaeeenue iiceoeaieie o 125 (77 %) oai?eo, ui cana?ae/oaaei i?i ?o aeinoaoith ?ioi?iaoeai?noue. Aioeaaie ca aeiiiiiaith oeoi?anoeaioieo ciiae?a aoei aeyaeaii o 32 (56 %) oai?eo ? a ?I?O o 31 (50,8 %) oai?iai, ui na?ae/eei i?i ?o ?ioi?iaoeai?noue. O iaoeo aeine?aeaeaiiyo ae?aaiic OeIA? aoei i?aeoaa?aeaeaii ia i?aenoaa? ia iaio aeaio iiceoeaieo ia?ea??a OeIA, i?e o?aooaaii? a?eo aeeoeie, aeooa?nueeiai aiaiiaco iaoa??, ee?i?ee caoai?thaaiiy. ?acoeueoaoe aecia/aiiy niaoeeo?/ieo ia?ea??a OeIA? aoei ii??aiyii c ee?i?/ieie i?iyaaie caoai?thaaiiy, ui aeicaieeei aeae?eeoe ee?i?ei-iaoiaaiaoe/i? oi?ie OeIA?: aino?o aai o?ii?/io, a ca nooiaiai aeoeaiino? ?ioaeoe?eiiai i?ioeano – noaee?i?/io (eaoaioio), aeoeaio aai ?aaeoeaiaaio (oaae. 3). Aiie ?icaeyaeaeenue ye noaae?? caaaeueiiai ?ioaeoe?eiiai i?ioeano ca aeaiia aa??aioaie: 1) aino?a oi?ia eaoaioia ?aaeoeaiaaia, eaoaioia 2) aino?a oi?ia o?ii?/ia ?aaeoeaiaaia. Oaaeeoey 3 Ee?i?ei-eaai?aoi?i? e?eoa??? ??cieo oi?i oeeoiiaaaeia??onii? ?ioaeoe?? A?aoiaoth/e iicieia?/i? oi?ie caoai?thaaiiy i?e iaaeoiaeaeaii? aei noaoe?iia?o, a i?ioean? ee?i?ei-eaai?aoi?iiai ianoaaeaiiy an?o oai?eo aoei ?iciiae?eaii ia 3 a?oie. O ia?oo a?oio (215 oai?eo) oa?eoee ae?oe c o?aaeaiiyi OeIN a?eii a?ae 1 i?nyoey aei 1 ?ieo 5 i?nyoe?a, ye? iaae?eoee a ?ioaeoe?eiee noaoe?iia? c ae?aaiicaie iai?ia?o, iai?iaiaioeaoae?o, A?A?, noaeiiiee neiae?ii oa ?ioeie o?aaeaiiyie OeIN. Aei ae?oai? a?oie oa?eoee ae?oe c eeoeiaith ?ioaeoe??th, a yeeo i?a?aaaaeaee neiioiie o?aaeaiiy oeoieiai-eeoeiaiai o?aeoo. Aei ia? aa?eoei 198 oai?eo a?eii a?ae 1 aei 9 i?nyoe?a. O?aoth a?oio i?aaenoaaeaii oai?eie ia ?ioaeoe?eiee iiiiioeeaic (38 ae?oae a?eii a?ae 1 aei 12 ?ie?a). Oeeo oai?eo aeae?eaii iaie iaaeiaaeeiai, oiio ui iaeiei c i?iya?a OeIA? iiaea aooe iiiiioeeaiciiiae?aiee neiae?ii. Ia i?aenoaa? aeaieo ee?i?ei-eaai?aoi?iiai ianoaaeaiiy oai?eo c o?aaeaiiyi OeIN, ?io?eiaaieo OeIA, aoei ?icae?eaii ia aea? i?aea?oie: ? i?aea?oia (67 in?a) – oai?? c iai?ia?oii oa iai?iaiaioeaoae?oii, ?? i?aea?oia (25 in?a) – ae?oe c A?A? oa noaeiiiei neiae?iiii. A?oie ii??aiyiiy neeaee 94 ? 25 in?a a?aeiia?aeii. Iienoth/e ee?i?/i? i?iyae oai?iae, ie c?oeioeenue c iniiaiith neeaaei?noth – a?aenooi?noth caaaeueiii?eeiyoi? eeaneo?eaoe?? OeIA? o ae?oae. O ca’yceo c oeei ae??oeee ca aeioe?eueia cai?iiiioaaoe na?e aa??aio eeaneo?eaoe??, yeee a?oioo?oueny ia aecia/aii? /ano ?io?eoaaiiy aeeoeie, a?aoiaoth/e ?ieoaaoe?eiee ia??iae, yeee ca?aeii c? S. Stagno (1990 ?.) neeaaea? a?ae 2 oeaei?a aei 4 i?nyoe?a. E?eoa??e /ano ?io?eoaaiiy aeeoeie ia? aaeeea cia/aiiy, oiio ui a?ae iueiai caeaaeaoue ee?i?/i? i?iyae oa e?ioeaaee ?acoeueoao OeIA?, ye? aeathoue ciiao anoaiiaeoe iaoai?cie ca?aaeaiiy: 1. Aioo??oiueioo?iaia ?io?eoaaiiy (iiyaa neiioii?a caoai?thaaiiy i?e ia?iaeaeaii? aai i?ioyaii ia?oeo aeaio oeaei?a). 2. ?io?aiaoaeueia ?io?eoaaiiy (iiyaa neiioii?a caoai?thaaiiy aai ia?ea??a ?ioaeoe?? i?ioyaii ia?oeo 4 i?nyoe?a aeeooy). 3. Iinoiaoaeueia ?io?eoaaiiy (neiioiie caoai?thaaiiy i?iyaeythoueny /a?ac 4 i?nyoe?, iaeiae iiaeooue aooe ? ?ai?oa). 4. ?io?eoaaiiy i?ney 1 i?nyoey aeeooy. ?aeiiaiaeiaaia eeaneo?eaoe?y aeicaiey? c?icoi?oe, /iio ee?i?/i? neiioiie OeIA? ia caaaeaee iai?oanoi? c ia?iaeaeaiiy, a iaeneiaeueii i?iyaeythoue naaa /a?ac 3-4 i?nyoe?, ia?aa?aath/e i?ae “ianeith” ?ioeo oai?ia. Oe? oi?ie ?ioaeoe?? a?ae??ciythoueny ia o?eueee ca iaoai?ciii ca?aaeaiiy, aea ? ??ciith ?ioiieiiiaoaioi?noth a i?aai?ci? aeeoeie, ui ia iiaea ia iaoe aieeao ia ia?aa?a oai?iae. ?c cai?iiiiiaaii? eeaneo?eaoe?? aeieeaa?, ui o?eueee aioo??oiueioo?iaia ?io?eoaaiiy i?ecaiaeeoue aei i?e?iaeaeaii? OeIA?, i?e oeueiio ?io?eoaaiiy ieiaea a?aeaoaa?oueny caaaeaee o?ainieaoeaioa?ii. Oea aeicaieeei iai aeae?eeoe a?oio oai?eo ?c aioo??oiueioo?iaiei o?aaeaiiyi OeIN (26 ae?oae) o a?oe? a?ae 1 aei 4 i?nyoe?a. O iaoa??a, ye? ia?iaeeee ae?oae c o?aaeaiiyi OeIN, o aeae?eueea ?ac?a /ano?oa, i?ae o a?oi? ii??aiyiiy, aeyaeyany iaoyaeaiee aeooa?nueeee aiaiiac. Oae, ia aeeeaei? oa ia?oaiia?iaeaeaiiy aeacoaaee 19,2 % iaoa??a, caa?ico c?eao aaa?oiino? – 27 %, ia?aae/ani? iieiae – 62 %. O a?oi? ii??aiyiiy ia aeeeaei? oa ia?oaiia?iaeaeaiiy aeacoaaee 4,5 % iaoa??a, caa?ico c?eao aaa?oiino? – 6,9 %, ia?aae/ani? iieiae – 9 %. I?e aea/aii? aiaiiaco aeeooy oeeo ae?oae iaa?ieia?/ia neiioiiaoeea c ia?iaeaeaiiy a?aei?/aeanue o 9 ?c 26 (35 %) oai?eo. O ieo ae?aaiinoiaaii ia?eiaoaeueio aioeaoaeiiao?th, a?ia?oaic?eii-a?ae?ioeaoaeueiee neiae?ii, a iaei??? aeeoeie c ia?iaeaeaiiy a?aei?/aeenue noaeiie, a ?ioi? – ae?aaiinoiaaii OeIA?, aioeaoae?o. I?aaenoaaeai? aeai? na?ae/eee i?i iiaeeeaino? i?eoiaaiiai ia?aa?ao aino?i? oace oeeoiiaaaeia??oniiai aioeaoae?oo, a oaeiae i?i iaaeinoaoith ae?aaiinoeeo o?aaeaiue OeIN o ae?oae a iinoiaoaeueiiio ia??iae?. A?eueo?noue ae?oae oe??? a?oie iaaeoiaeeee aei ?aai?iaoe?eiiai a?aeae?eaiiy c ae?aaiicaie: iai?ia?o, i?e?iaeaeaia iaoieia?y OeIN, A?A? ?c noaeiiiei oa iai?iaaaeueiei neiae?iiaie, ia?eiaoaeueia aioeaoaeiiao?y. Oyaee?noue noaio o aeine?aeaeoaaieo ae?oae aoea iaoiiaeaia iaa?ieia?/iith neiioiiaoeeith ? oea?aa?aeueiith iaaeinoaoi?noth (oaae.4). Ae?aiacii o?aaeaiue OeIN i?e OeIA? iaaeoi oe?ieee – a?ae eaaeaa iii?oiiai neiae?iio i?eai?/aiiy OeIN aei iaeaaae/eo o?aaeaiue iiceo – ?icaeoeo oeeoiiaaaeia??oniiai aioeaoae?oo ? iai?iaiaioeaoae?oo. Iaea?eueo oyaeeei i?iyaii o?aaeaiiy OeIN aoa ?icaeoie oeeoiiaaaeia??oniiai aioeaoae?oo ? iai?iaiaioeaoae?oo, ye? oa?aeoa?ecoaaeenue ii?ooaiiyi na?aeiiino?, eeii?ei-oii?/ieie noaeiiaie, ai?ci?aoeaen??th, iaoieia?/ieie ?aoeaenaie. Oaaeeoey 4 Iniiai? neiioiie ? neiae?iie o?aaeaiiy OeIN i?e OeIA? o ae?oae O e?eai?? o 18 oai?eo a?aei?/aany iii??iee (o iaaeao aeaicia/ieo aai o?ueiocia/ieo oeeo?) oeeoic ci?oaiiai oa?aeoa?o c a?eeiai-ee?oeiiith aeenioe?aoe??th. Iieacieee a?eea neeaee a?ae 1,0 aei 4,0 a/e. O 5 c 22 oai?eo naiaoe?y e?eai?o a i?ioean? e?eoaaiiy ia a?aeaoaaeanue, a a?aei?/aeanue eeoa oaiaeaioe?y aei cieaeaiiy iieaciee?a oeeoico. Aaeoa??ieia?/ia aeine?aeaeaiiy e?eai?o ? e?ia? aeicaieeei aeyaeoe, ui o 5 oai?eo oe??? a?oie ao?ieia?/iei oaeoi?ii iai?ia?oo aoa iai?iaieie A, yeee o 2 ae?oae aoei aeae?eaii c e?ia?, o 2 – c e?eai?o ? o 1 – c e?eai?o ? e?ia?. O ?aooe oai?eo ae?aaiic caeeoeany ao?ieia?/ii ia aa?eo?eiaaiei. Oyaee?noue iaa?ieia?/ieo ii?ooaiue o oai?eo c iai?iaiaioeaoae?oii aoea cia/iith, o 8 ?c 26 niinoa??aaeanue aeeaiea ?iaae?aeecaoe?y o aeaeyae? a?oai? cao?eiee ineoiiioi?iiai ?icaeoeo, ao?aoe na?aeiiino? oa niiioaiii? ?ooiai? aeoeaiino?, iayaiiai nianoe/iiai oao?aia?aco c /anoeiaeie oieaeueieie noaeiiaie. Ii?yae c ee?i?eith iai?iaiaioeaoae?oo iae/ano?oa aeyaeyeenue a?ia?oaic?eii-a?ae?ioeaoaeueiee neiae?ii (21 oai?ee), ?icoe?aiiy oeoii/eiai? nenoaie iiceo (23), noaeiiiee neiae?ii (18). Iacaaaeath/e ia oa, ui o ee?i?oe? i?ia?aeiith aoea iaa?ieia?/ia neiioiiaoeea, aeacaiee i?ioean ia caaaeaee aoa ?cieueiaaiei. O 10 c 26 oai?eo (38,5 %) a?aei?/aeinue o?aaeaiiy eaaaiue, yea noi?iaiaeaeoaaeinue oeiiaeie aeey aiaieuaai? aai ?ioa?noeoe?aeueii? iiaaiii?? ee?i?ei-?aioaaiieia?/ieie ci?iaie. Ii?aeiaiiy iaa?ieia?/ii? neiioiiaoeee c o?aaeaiiyi a?iioieaaaiaai? nenoaie na?ae/eei i?i aaia?ae?caoe?th ?ioaeoe?? ? ni?eyei a?eueo?e o?eaaeino? eeoiiaiee – aei 14±2,75 aeiy (a eiio?ieuei?e a?oi? 4,38±0,42 aeiy, ?<0,001) oa neiioii?a oieneeico. Inoaoi/ia ae?aaiinoeea o?aaeaiue OeIN aoea iiaeeeaa i?ney i?iaaaeaiiy aoiaioeaoaeineii??, iae?ineii?? oa I?O aieiaiiai iiceo. O 17 oai?eo aeyaeaii iciaee aioo??oiuei/a?aiii? a?ia?oaic?? ??ciiai nooiaith, o 15 – ci?ie oeoii/eiai? nenoaie o aeaeyae? aneiao?e/iiai aai neiao?e/iiai ?o ?icoe?aiiy, o 5 oai?eo – ?icoe?aiiy 3-ai oeoii/ea iiceo. Aei /ano aeienee ?c noaoe?iia?o i?iyae aaio?eeoeiiaaae?? caa??aaeenue o 23 oai?eo. I?O aieiaiiai iiceo i?aeoaa?aeaeoaaea ? aeiiiaithaaea ea?oeio iaoieia?/ieo i?ioean?a, ye? aoei aeyaeaii i?e oeueo?acaoeiaiio aeine?aeaeaii?. Ca aeiiiiiaith I?O ciaeaeaii ia?aaaio?eeoey?i? e?noe o 3 oai?eo, aiaioeaoae?y o 1 aeeoeie, ?icoe?aiiy noaa?aoii?aeaeueii? ii?iaeieie o 15 oai?eo. I?e oeeoineii?/iiio aeine?aeaeaii? neeie, na/? oa e?eai?o niaoeeo?/i? ee?oeie oeio “niaeia iei” aeyaeaii o 23 ?c 26 oai?eo (88,5 %). Ne?ae a?aecia/eoe, ui a 57 % aeiaaee?a oe? ee?oeie ciaeaeaii o e?eai??, ui ? iniaeeai cia/ouei o oai?eo c iaa?ieia?/iith neiioiiaoeeith. Ca aeaieie ?ioiioa?iaioiiai aeine?aeaeaiiy o 13 (50 %) oai?eo aeyaeaii iecueeiaa?aei? Ig G c ?iaeaenii aa?aeiino? a?ae 8 % aei 36 %, c ieo o 6 (23,1 %) – niaoeeo?/i? Ig I, ye? na?ae/aoue i?i aino?o OeIA? oa aeoeai?noue ?ioaeoe?eiiai i?ioeano. O 9 (34,6 %) oai?eo anoaiiaeaii aenieiaa?aei? aioeo?ea Ig G c ?iaeaenii aa?aeiino? a?eueoa 45 %, ui c o?aooaaiiyi a?eo oai?eo (aei 4 i?nyoe?a) aiai?eoue i?i aeaai?noue ?ioaeoe?eiiai i?ioeano ? i?i o?ii?/io oi?io OeIA?. ?acoeueoaoe aeine?aeaeaiiy ca aeiiiiiaith a?a?eaeecaoe?eiiai iaoiaeo aeicaieeee aeyaeoe OeIA o eiioeaio?aoe?? a?ae 10-2 aei 10-5 iea/i?ia. I?e oeueiio o ae?oae c o?ii?/iei ia?aa?aii caoai?thaaiiy AeIE-OeIA ciaeaeaii ia a e?ia?, a a e?eai??. Oaeei /eiii, aiae?c ?acoeueoao?a ee?i?ei-?ino?oiaioaeueiiai ianoaaeaiiy iieacaa, ui o 21 (80,8 %) c 26 oai?eo oe??? a?oie iaee i?noea noi?iiaai? i?aai?/i? o?aaeaiiy OeIN, ye? iaoiiaeai? aioo??oiueioo?iaiei ?io?eoaaiiyi ieiaeo. Ie?aio a?oio (41 oai?ee) neeaee ae?oe c ai?eiei iai?ia?oii o a?oe? a?ae 4 i?nyoe?a aei 1 ?ieo 5 i?nyoe?a, ye? aoee ?io?eiaai? OeIA. O 36,6 % oai?eo ae?aaiinoiaaii iai?iaieieiaee iai?ia?o, o ?aooe aeiaaee?a ?icoeo?oaaoe ao?ieia?th iai?ia?oo ia aaeaeinue. Aeyaeaii iaoyaeoth/ee aieea OeIA ia ia?aa?a ai?eiiai iai?ia?oo. Oea noinoaaeinue ia o?eueee a?eueoi? /anoioe iniiaieo neiioii?a, aea e ?o aeiaaio?eaaeino?, no?ie?a naiaoe?? e?eai?a, ia?aaoaaiiy oai?iai a noaoe?iia??. O?eaae?noue aa?y/ee oa ?ioieneeaoe?? a iniiai?e ? eiio?ieuei?e a?oiao aoee i?aeoe/ii iaeiaeiaeie. Iaeiae aeiaaio?eaae?noue noaeiiiiai neiae?iio, iayai?noue iai?iaaaeueieo neiioii?a ? no?iee naiaoe?? e?eai?o a??ia?aeii ??cieeenue a?ae a?oie ii??aiyiiy. Oae, caiaeuei? ci?ie a e?eai?? o oai?eo, ?io?eiaaieo OeIA, caa??aaeenue 9,71±0,75 aeiy, a a a?oi? ni?anoaaeaiiy – 6,31±0,34 aeiy (?<0,001). Aeai? eaai?aoi?iiai aeine?aeaeaiiy aeicaieeee aeyaeoe iayai?noue niaoeeo?/ieo OeIA-ee?oei a inaaeeao na/? oa neeie o 28 c 41 oai?iai (68 %), aei oiai ae /ano?oa ?o ciaoiaeeee o na/? (34 %) i?ae o neei? (19,5 %). Aeyaeaiiy iecueeiaa?aeieo aioeo?e, c ?iaeaenii aa?aeiino? a?ae  6 % aei 29 %, aeaei i?aenoaao i?eioneaoe ?io?eoaaiiy OeIA ae?oae i?ney ia?iaeaeaiiy ? iayai?noue aino?iai ?ioaeoe?eiiai i?ioeano. O oe?e a?oi? oai?eo niinoa??aaee 12 ae?oae a?eii a?ae 7 i?nyoe?a aei 1 ?ieo 2 i?nyoe?a, o yeeo ?io?eoaaiiy OeIA ia aieeaaei ia ia?aa?a oa cae?i/aiiy iai?ia?oo. Oea aeicaieeei aeae?eeoe noaee?i?/io oi?io OeIA?, yeo aoei ae?aaiinoiaaii ca aeiiiiiaith aeniei/ooeeaiai iaoiaeo aeine?aeaeaiiy – AeIE-a?a?eaeecaoe??. O oeeo ae?oae niaoeeo?/i? ee?oeie ia aecia/aeenue, aea a ne?iaaooe? e?ia? aeyaeyeenue niaoeeo?/i? Ig G c ?iaeaenii aa?aeiino? a?ae 6 % aei 19 %. Iaeiei c /anoeo i?iya?a o?aaeaiiy OeIN o ae?oae ?aiiueiai a?eo ? noaeiiiee neiae?ii, ?noeiio i?e/eio yeiai ia caaaeaee iiaeeeai anoaiiaeoe. Oiio ie?aio a?oio neeaee 52 oai?eo c A?A? oa noaeiiiei neiae?iiii. I?e ianoaaeaii? ia a??oni? aioeaaie iaea?eueo ?iciianthaeaeaieo a??onieo ?ioaeoe?e o 13 (25 %) oai?eo ae?aaiinoiaaii aaeaiia??onio ?ioaeoe?th, o 10 (19,2 %) – a?ei aai ia?aa?ei, o 6 (11,5 %) – ?N-?ioaeoe?th. O 25 (48,1 %) oai?eo aeyaeaii ?io?eoaaiiy OeIA. I?e oeueiio o 15 (60 %) c ieo OeIA? ae?aaiinooaaeanue o aeiaaeeo A?A? iac’yniaaii? ao?ieia??. I?e ii??aiyii? aeaio a?oi ae?oae aoei a?aei?/aii a??ia?aei? ??cieoe? a ee?i?/ieo neiioiiao caoai?thaaiiy. O 14 ?c 25 (56 %) oai?eo, ?io?eiaaieo OeIA, eaoa?aeuei? i?iyae aoee neaai ae?aaeai?, a o 9 (36 %) – ?o ia aoei. O ee?i?/i?e ea?oei? ia ia?aaei?e ieai aenooiaea iaa?ieia?/ia neiioiiaoeea: cao?eiea ineoiiioi?iiai ?icaeoeo o 10 (40 %) oai?eo, a?ia?oaic?eiii-a?ae?ioeaoaeueiee neiae?ii – o 9 (36 %). I?e aoiaioeaoaeineii?? ? iae?iniiineii?? o 11 (44 %) oai?eo ae?aaiinoiaaii aioo??oiuei/a?aiio a?ia?oaic?th, o 10 (40 %) – ?icoe?aiiy aieiaeo oeoii/e?a iiceo ? o 3 (12 %) – ii?aeiaiiy ?icoe?aieo aieiaeo oeoii/e?a c ?icoe?aiiyi ??? oeoii/eo aieiaiiai iiceo. Iaoieia?/ieo ci?i a e?eai?? ia aeyaeaii, ca aeiyoeii iaei??? aeeoeie, o yei? a ii?iaeueiiio e?eai?? aeyaeaii OeIE. Ii?yae c o?aaeaiiyi ia?aiai? nenoaie, o oeeo oai?eo a?aei?/aeanue iie?aaeai?y, aaiaoiiaaae?y, a?iioiiano?oeoeaiee neiae?ii, iiaaiii?y. ?io?eiaai?noue OeIA iaoyaeoaaea ia?aa?a iniiaiiai caoai?thaaiiy. A?aei?/aii i?ci?oo ii?iae?caoe?th oaiia?aoo?e o?ea a ii??aiyii? c a?oiith eiio?ieth oa a?eueo o?eaaeee noaeiiiee neiae?ii. Eeoiiaiea o oai?eo, ?io?eiaaieo OeIA, caa??aaeanue 5,09±0,15 aeiy, a a a?oi? ni?anoaaeaiiy – 3,7±0,22 aeiy (?<0,01). Noaeiiiee neiae?ii – 2,46± 0,23 ? 1,26±0,44 aeiy a?aeiia?aeii (?<0,05). I?iya ? o?eaae?noue ee?i?/ieo neiioii?a iicia/eeenue ia o?eaaeino? ia?aaoaaiiy ae?oae a noaoe?iia??, ui neeaei a iniiai?e a?oi? 12,5±0,6 aeiy, a a a?oi? ii??aiyiiy – 6,03±0,52 aeiy (?<0,01). Aeyaeaiiy niaoeeo?/ieo ee?oei, aenieiaa?aeieo aioeo?e ? aaiiio AeIE-OeIA o ne?iaaooe? e?ia? a ii?aeiaii? c ee?i?/ieie i?iyaaie aeicaieeee a oe?e a?oi? oai?eo ae?aaiinooaaoe OeIA?, aeoeaio oi?io, yeo o 15 oai?eo ie aaaaeaee iniiaiei caoai?thaaiiyi, a o 10, o yeeo aeae?eai? aaeaiia??on, a??on ia?aa?eio, ?N-a??on – ye noiooi? caoai?thaaiiy aai ci?oaio ?ioaeoe?th. Iiaeia i?eionoeoe, ui iaei??th c i?e/ei ?icaeoeo o oeeo ae?oae noaeiiiiai neiae?iio ? ae?y OeIA ia OeIN. Aea/ath/e aca?iica’ycie ye?nieo iciae c canoinoaaiiyi e?eoa??y c2, ie onoaiiaeee ei?aeyoe?eio caeaaei?noue i?ae aeyaeaiiyi OeIE c inaaee?a neeie ? iayai?noth noaeiiiiai neiae?iio, eiao?oe??io ei?aeyoe?? neeaa +0,5 ? oeae ca’ycie ? caeiiii??iei. Ie?aio a?oio neeaee 198 ae?oae ia?oiai ?ieo aeeooy c o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo. Aiie iaae?eoee aei ee?i?ee ia?aaaaeii c ae?aaiicii aano?iaioa?ieie?o ? aioa?ieie?o. Ia?aaaaeaee ae?oe ia?oeo o?ueio i?nyoe?a aeeooy – 108 (54,5 %). Ao?ieia?th aino?i? eeoeiai? ?ioaeoe?? aeyaeaii o?eueee o 126 (63,3 %) ae?oae. Iae/ano?oa aeyaeyany naeueiiiaeueic (18,2 %) ? aano?iaioa?ieie?oe, iaoiiaeai? oiiaii-iaoiaaiiith i?e?ioei?ith (i?ioae, eeaan?aea) – 18,2 %. I?e iaaeoiaeaeaii? 127 (64 %) oai?eo aoee o oyaeeiio aai iaaeoi oyaeeiio noai?, ui noaei i?e/eiith ?o ni?yioaaiiy aei ?aai?iaoe?eiiai a?aeae?eaiiy. Oyaee?noue noaio aoea iaoiiaeaia ?ioieneeaoe??th, eie?oiei neiae?iiii, i?iyaaie aeneeico, iaa?ieia?/iith neiioiiaoeeith, iani?eyoeeaei i?aii?a?aeiei oiiii (iaaeiiioai?noue, ia?eiaoaeueia aioeaoaeiiao?y, a?iio?io?y). C iaoith aea/aiiy aieeao ?io?eoaaiiy OeIA ia ia?aa?a eeoeiaeo ?ioaeoe?e aoei i?iaaaeaii ii??aiyeueia aea/aiiy ee?i?ei-eaai?aoi?ieo aeaieo o aeaio a?oiao oai?eo: iniiai?e – 119 ae?oae, ?io?eiaaieo OeIA, ? eiio?ieuei?e – 76 ae?oae, o yeeo ?acoeueoaoe aeine?aeaeaiue ia OeIA? aoee iaaaoeaieie. Noai caei?ia’y ae?oae i?e ia?iaeaeaii? iieacaa o?niee ca’ycie i?ae aioo??oiueioo?iaiei ?icaeoeii aeeoeie, ia?eiaoaeueiei ia??iaeii ? aeooa?nueei-a?iaeieia?/iei aiaiiacii iaoa??a oeeo ae?oae. O a?eueoino? iaoa??a iniiaii? a?oie ia?aa?a inoaiiuei? aaa?oiino? aoa iaoieia?/iei. Iae/ano?oa oea aoea caa?ica c?eao aaa?oiino? – o 34 (28,6 %) ae?iie, a a a?oi? ii??aiyiiy – o 13 % (?<0,05). Ia?aae/ani? iieiae oaeiae /ano?oa a?aei?/aeenue o a?oi? ?io?eiaaieo – 15 % ? 5,3 % (?<0,05) a?aeiia?aeii. Iaoieia?y aaa?oiino? o iaoa??a iani?eyoeeai a?aeaeaaeanue ia noai? ae?oae i?e ia?iaeaeaii?. Oae, o a?oi? ii??aiyiiy aioo??oiueioo?iaia a?iio?io?y niinoa??aaeanue o 10,5 % oai?eo ? iaee i?noea iiiaeeiie? aeiaaeee ia?eiaoaeueii? aioeaoaeiiao?? (2,6 %), oiae? ye a iniiai?e a?oi? aiie cono??/aeenue iaeiaeiai /anoi (aioo??oiueioo?iaia a?iio?io?y o 21,8 %, a ia?eiaoaeueia aioeaoaeiiao?y – o 20,2 % oai?eo). Ae?oe, ?io?eiaai? OeIA, ia o?eueee ia?iaeaeoaaeenue c iaoieia??th, aea ? a iiaeaeueoiio ?icaeaaeenue a??oa. A aiaiiac? o ieo cia/ii /ano?oa, i?ae o a?oi? ii??aiyiiy, a?aei?/aeenue a?iioieaaaiaa? caoai?thaaiiy ? eeoeia? ?ioaeoe?? (43,7 % ? 21,1 % a?aeiia?aeii, ?<0,001). Aiie iaaeinoaoiuei i?eaaaeyee a ian? o?ea, ? oiio iniiaiei ee?i?/iei neiioiiii i?e iaaeoiaeaeaii? a noaoe?iia? aoea a?iio?io?y ??ciiai nooiaiy, yea a iniiai?e a?oi? a?aei?/aeanue o 111 (93 %) oai?eo, a a a?oi? ii??aiyiiy – o 32 (42 %). A?iio?io?y ia?oiai nooiaiy a?aei?/aeanue iaeiaeiai /anoi a iaio a?oiao oai?eo (16 % ? 14,5 % a?aeiia?aeii, ?>0,05), oiae? ye a?iio?io?y 2-ai nooiaiy a 2,5 ?ace /ano?oa
con??/aeanue a iniiai?e a?oi?, i?ae o eiio?ieuei?e (63,9 % ? 26,3 %,
?<0,01), a a?iio?io?y 3-ai nooiaiy a?aei?/aeanue, ye i?aaeei, o?eueee o ae?oae, ?io?eiaaieo OeIA (13,4 % ? 1,3 %, ?<0,01). I?e caaaeuei?e noiaeino? ee?i?/ii? neiioiiaoeee o ae?oae c AE? a iaio a?oiao a?aei?/aeenue ?ic??ciaiiy i?ae i?iyaaie o?eaaeino? iniiaieo ee?i?/ieo neiioii?a. Neiae?ii ?ioieneeaoe?? a iniiai?e a?oi? caa??aaany ia oeaeaeaiue aeiaoa, i?ae o a?oi? ii??aiyiiy ? neeaa 16,9±1,8 noi?ioea 10,1±0,8 aeiy (?<0,001), a aeenooieoe?y eeoa/ieea 9,6±0,7 ? 6,3±0,3 aeiy a?aeiia?aeii (?<0,01). Ca?eueoaiiy ia/?iee o ae?oae iniiaii? a?oie cono??/aeinue a 1,4 ?aca /ano?oa, i?ae o a?oi? ii??aiyiiy. O?aaeaiiy ia?aiai? nenoaie, yea i?iyaeyeinue aioeaoaeiiao??th, noaeiiiei ? a?ia?oaic?eii-a?ae?ioeaoaeueiei neiae?iiaie, a i?e OCAe – ?icoe?aiiyi oeoii/eiai? nenoaie iiceo a?aei?/aeinue o 3 ?ace /ano?oa o ae?oae, ?io?eiaaieo OeIA. Ii?yae c o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo a iaoieia?/iee i?ioean caeo/aeanue a?iioieaaaiaaa nenoaia. O 35 oai?eo c OeIA? aoei anoaiiaeaii, ui ?aioaaiieia?/i? ci?ie i?aai?a a?oaeii? ee?oee iiae?ai? oei, ui aoaathoue i?e aino?iio a?iio?o?, yeee aeeeeeaii A?A?, aea, ia a?aei?io a?ae inoaiiueiai, ci?ie a eaaaiyo noi?iaiaeaeoaaeenue ae?aaeaiei a?ia?iiaaiaoicii, ?icaeoeii iiaaiii?e o 21 (60 %) oai?iai ??ciiai nooiaiy ae?aaeaiiy ? aoaeaeoac?a o 13 (37,1 %) ae?oae. ?io?eoaaiiy ae?oae OeIA ni?eyei aaae/iio ia?aa?ao AE?, ui aieeaaei ia oa?i?i ia?aaoaaiiy a noaoe?iia??. Ae?oe iniiaii? a?oie ciaoiaeeeenue o ee?i?oe? 24,0±0,5 aeiy, a a?oie ii??aiyiiy – 16,2±2,2 aeiy (?<0,001). Aeyaeai? ?ic??ciaiiy a ee?i?/iiio ia?aa?ao AE? a ii??aithaaieo a?oiao i?aeoaa?aeaeoaaeenue aaiaoieia?/ieie ci?iaie. Caaaeueiith oaiaeaioe??th o ?io?eiaaieo OeIA ae?oae aoea noeeuei?noue aei ?icaeoeo aiai?? (Ia – 104±1,7 a/e i?ioe 112±2 a/e, ?<0,01) ? o?iiaioeeoiiai?? (186±3,2o109/e ? 205±4,2o109/e a?aeiia?aeii, ?<0,01). Aiai?y a?aei?/aeanue a iaio a?oiao oai?eo, aea na?aae ?io?eiaaieo OeIA aoea ae?aaeaia cia/i?oa, ca ?aooiie ae?oae, o yeeo iieaciee aaiiaeia?io aoa iaaeoi iecueeei (ieae/a 90 a/e, 15,1 % i?ioe 2,6 % a eiio?ieuei?e a?oi?, ?<0,001). Aeeni?ioa?iai?y niinoa??aaeanue o ae?oae iaio a?oi. Caaaeueiee a?eie a iniiai?e a?oi? neeaa 49,5±1,5 a/e, a a a?oi? ii??aiyiiy – 53,2±1,4 a/e (?>0,05). Iaeiae cieaeaiiy ai?noo aaiaaeiaoe?i?a aoei a?eueoa ae?aaeaia
a ?io?eiaaieo OeIA (7,02±0,53 % ? 9,08±0,48 %, ?<0,001). Aeieeaaeiee aiae?c ee?i?/ieo i?iya?a ? ?acoeueoaoe a??onieia?/ieo oa ?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiue aeicaieeee o ?io?eiaaieo OeIA aeyaeoe ??ci? oi?ie OeIA? a caeaaeiino? a?ae aeoeaiino? ?ioaeoe?eiiai i?ioeano. Ia?oo a?oio neeaee 36 ae?oae (30,3 %) c 119 oai?eo, o yeeo i?ney iaiaeii?aciaeo iaaaoeaieo aaeoa??ieia?/ieo aeine?aeaeaiue ia eeoeiao a?oio ? aeyaeaiiy iiceoeaieo ia?ea??a OeIA?, iniiaiei caoai?thaaiiyi ae?aaiinoiaaii OeIA?. O 22 oai?eo aeyaeaiiy OeIE o neei? oa na/? ii?aeioaaeinue c iecueeei ?iaeaenii aa?aeiino?, ui na?ae/eei i?i aino?o oi?io OeIA?. O 14 oai?eo oe??? a?oie OeIE ia?aaaaeii aoei aeyaeaii a neei? oa na/?, a ca iaoiaeii ?OA aecia/aeenue aenieiaa?aei? aioeo?ea, ui aeicaieeei i?eionoeoe o?ii?/io oi?io, iiaeeeai, c aioo??oiueioo?iaiei ?io?eoaaiiyi. Aeaoaeoe?y aaiiio iaoiaeii AeIE-a?a?eaeecaoe?? i?aeoaa?aeaeoaaea iayai?noue aeoeaiiai i?ioeano. Oaeei /eiii, aano?iaioa?ieie?o oeeoiiaaaeia??onii? ao?ieia?? ae?aaiinoiaaii o 36 c 198 oai?eo (18,2 %), a a a?oi? oai?eo c eeoeiaith ?ioaeoe??th iaooi/iaii? ao?ieia?? – o 36 c 69 (52,2 %). Ae?oao a?oio ?c caaaeueii? e?eueeino? ?io?eiaaieo neeaee 69 oai?eo (58 %), o yeeo iniiaiei ae?aaiicii aoea eeoeiaa ?ioaeoe?y, yeo aoei i?aeoaa?aeaeaii aen?aii iaoiaaiii? aai oiiaii-iaoiaaiii? oei?e, a OeIA? ?icaeyaeaeanue ye noiooiy iaoieia?y. Naia a oe?e a?oi? oai?eo niinoa??aaeenue cia/i? iniaeeaino? a oyaeeino? ee?i?/ieo i?iya?a AE? oa ?o o?eaaeino?, o?aaeaiiy OeIN o ii??aiyii? c eiio?ieueiith a?oiith. Iaeiae o a?eueoino? oai?eo oe??? a?oie – o 48 c 69 (69,6 %) – aecia/aeenue iecueeiaa?aei? aioeo?ea, ui na?ae/eei i?i aeoeai?noue ?ioaeoe?eiiai i?ioeano. Oiio ia cian?i a??ii ?icaeyaeaoe OeIA? ye noiooith iaoieia?th, iaiao?aeii aiai?eoe i?i i?eno-?ioaeoe??. Oaeiae iiaeeeai, ui ia oe? ia?aeiii? OeIA?, yea iiieaeoaaea ?ioii?aaeoeai?noue aeeoeie, iaoa?oaaeanue aaeoa??aeueia ?ioaeoe?y. O 14 ae?oae (11,8 %) ?c 119 ia?nenoaioe?y OeIA ia aeyaeyea iii?oiiai aieeao ia ia?aa?a ? e?ioeaaee ?acoeueoao eeoeiai? ?ioaeoe??. I?e oeeoineii?? niaoeeo?/i? ee?oeie ia aeyaeyeenue, a a ne?iaaooe? e?ia? aecia/aeenue niaoeeo?/i? aenieiaa?aei? aioeo?ea ? ia?ea? a??onii? ?aie?eaoe?? – AeIE-OeIA. Oea aeicaieeei aeae?eeoe noaee?i?/io, aai eaoaioio, oi?io OeIA?, ae?aaiinooaaoe yeo iiaeeeai o?eueee ca aeiiiiiaith aeniei/ooeeaeo iaoiae?a aeine?aeaeaiiy. A?oio ?c 38 oai?eo (8,4 %) neeaee ae?oe, ye? iaae?eoee aei ee?i?ee c ae?aaiicii ?ioaeoe?eiee iiiiioeeaic a?eii a?ae 1 aei 12 ?ie?a. A?aeiii, ui eiai caoaeiee (a??on Aiooaeia-Aa??a) iaeaaeeoue aei ?iaeeie a??on?a aa?iana, ye ? OeIA. Iaeiei c i?iya?a OeIA? iiaea aooe iiiiioeeaiciiiae?aia oi?ia oai?iae. Niaoeeo?/i? eaai?aoi?i? iaoiaee aeicaieeee i?iaanoe aeeoa?aioe?aeueio ae?aaiinoeeo oeeo aeaio oi?i caoai?thaaiiy. Ia i?aenoaa? aecia/aiiy ia?ea??a OeIA aoei aeae?eaii aea? a?oie oai?eo. Ia?oo (iniiaio) neeaee 20 in?a, o yeeo aoei ae?aaiinoiaaii iiiiioeeaiciiiae?aio oi?io OeIA?. Aei ae?oai? a?oie (eiio?ieueii?) a?eoei 14 ae?oae, o yeeo ia aoei aeyaeaii ia?ea?e OeIA. O 4 oai?eo io?eiai? inaaaeiiiceoeai? ?acoeueoaoe, oiio aiie ia aa?eoee i? a iaeio c a?oi niinoa?aaeaiiy. A?aeiii, ui oyaee?noue ?ioaeoe?eiiai iiiiioeeaico aecia/a?oueny nooiaiai o?aaeaiiy caeo/aieo aei i?ioeano e?ioi?aeieo i?aai?a. O ee?i?/i?e ea?oei? a?aei?/aeenue aa?y/ea, oiicee?o, iie?aaeai?o, ca?eueoaiiy ia/?iee ? naeac?iee. Iiae?ai? neiioiie aeyaeaii ? i?e iiiiioeeaiciiiae?ai?e oi?i? OeIA?. Iniiai? ee?i?/i? neiioiie caoai?thaaiiy a iaio a?oiao oai?eo ioe?ithaaee a aaeao. Aoei aeei?enoaii iaoiae aeueoa?iaoeaiiai aa??thaaiiy. Ii?ia a?aei?/aeanue ye 0 aae?a; aeyaeai? a?aeoeeaiiy a?ae ii?ie, a caeaaeiino? a?ae i?iyao iaoieia?/iiai neiioiio, ioe?ithaaeenue a 1, 2, 3 aaee. A??ia?aei?noue ?ica?aeiinoae aeyaeaia o?eueee ca aeaiia ee?i?/ieie neiioiiaie (ca?eueoaiiy e?ioiaoce?a ? oiicee?o). Oae, iie?aaeai?y o oai?eo c OeIA? neeaea 1,1 aaea, a a a?oi? ii??aiyiiy – 2,07, oiicee?o – 0,5 ? 1,4 aaea a?aeiia?aeii. Aaiia?aie aeacoaaee ia i?iaeoeoeaiee oa?aeoa? caiaeaiiy c ae?aaeaiei e?ioioeeoicii a iaio a?oiao oai?eo, iiiioeeoic – o?eueee a a?oi? ii??aiyiiy. Ioaea, iiiiioeeaiciiiae?aia oi?ia OeIA? ia noi?iaiaeaeo?oueny oiicee?oii ? iiiioeeoicii, e?ioaaeaiiiao?y – iacia/ia. I?iaaaeai? aeine?aeaeaiiy iieacaee, ui iiiiioeeaiciiiae?aio oi?io OeIA? iiaeia ?icaeyaeaoe ia o?eueee ye aino?a caoai?thaaiiy, aea ? ye iane?aeie o?ii?/ii? aai eaoaioii? ?ioaeoe?? c iiaeaeueoith ?aaeoeaaoe??th OeIA. Ia i?aenoaa? ee?i?ei-eaai?aoi?ieo iieaciee?a ?ic?iaeaii aeai?eoi ianoaaeaiiy oai?eo c iaoith anoaiiaeaiiy ae?aaiico OeIA?, a yeiio ia?aaeaa/aii aecia/aiiy oaeoi??a ?eceeo ?io?eoaaiiy OeIA, nie?ath/enue ia aeai? aeooa?nueeiai aiaiiaco iaoa?? oa aiaiiaco aeeoeie, ee?i?/iiai ? eaai?aoi?iiai aeine?aeaeaiiy (noaia 1). Aa?o/e aei oaaae ?acenoaioi?noue OeIA aei aaaaoueio i?ioea??onieo i?aia?ao?a, a oaeiae eiai caeaoi?noue aei o?eaaei? ia?nenoaioe??, ie aia?oa i?e ??cieo ee?i?/ieo oi?iao OeIA? aeei?enoiaoaaee a?o/eciyiee ?aeiia?iaioiee a-2b-?ioa?oa?ii – eaoa?ii. E?eoaaeueio aoaeoeai?noue eaoa?iio aea/aii o 54 oai?eo c OeIA?, ?iciiae?eaieo ia o?e a?oie: ia?oo a?oio neeaee 26 ae?oae (a?eii a?ae 2 aei 6 i?nyoe?a) c o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo, ae?oao – 16 ae?oae (a?eii a?ae 1 i?nyoey aei 7 i?nyoe?a) c o?aaeaiiyi OeIN ? o?aoth – 12 ae?oae (a?eii a?ae 2 aei 7 ?ie?a) c iiiiioeeaiciiiae?aiith oi?iith OeIA?. Eaoa?ii i?ecia/aany aioo??oiueii’yciai, uiaeaiii 50 oen.II/ea iane i?ioyaii 7-10 aei?a. I?e ae?a?aeiiio neiae?ii? eiai aeei?enoiaoaaee ?aeoaeueii, o aeaeyae? i?e?iee?ci ii 100 oen.II uiaeaiii i?ioyaii 3-7 aei?a. Eiio?ieuei? a?oie neeaee oai?? oiai ae a?eo. Oai??, a caeaaeiino? a?ae iicieia?/ii? oi?ie caoai?thaaiiy, io?eiaee eiiieaenia e?eoaaiiy, yea aeeth/aei aeac?ioieneeaoe?eio oa i?ioecaiaeueio oa?ai?th, aioea?ioeee, aoa?ioeee, a?oai?ie, noaeeii? caniae. Iaea?eueo ae?aaeaiee e?eoaaeueiee aoaeo io?eiaii a a?oi? oai?eo c caeo/aiiyi o i?ioean i?aai?a oeoieiai-eeoeiaiai o?aeoo. ?i eaoa?ii i?ecia/aany ye aioo??oiueii’yciai, oae ? ?aeoaeueii. Iiceoeaia ee?i?/ia aeeiai?ea i?iyaeyeanue ciaioaiiyi o?eaaeino? aa?y/ee ia 2,4 aeiy, oaeaeoith ii?iae?caoe??th aeii?iaeiaiue. Ia o?eaae?noue ae?a?aeiiai neiae?iio aieeaaa niin?a aaaaeaiiy i?aia?aoo. Oae, o?eaae?noue ae?a?aeiiai neiae?iio o?eueee i?e eiai aioo??oiueii’yciaiio aaaaeaii? neeaea 6,3±0,26 aeiy, i?e ii?aeiaiiio i?ecia/aii? (aioo??oiueii’yciai ? ?aeoaeueii) – 3,8±0,43 aeiy, a a a?oi? ii??aiyiiy – 9,1±0,53 (?<0,001). Eiiieaenia oa?ai?y ?c canoinoaaiiyi eaoa?iio ni?eyea ciaioaiith o?eaaeino? canoinoaaiiy aioeaaeoa??aeueii? oa ?iooc?eii? oa?ai??, ui neeaei 8,4±0,44 i?ioe 11,1±0,77 aeiy (?<0,01) ? 4,1±0,29 i?ioe 5,6±0,34 aeiy a?aeiia?aeii (?<0,01). I?ney canoinoaaiiy eaoa?iio a?aei?/aeinue cieaeaiiy aioeaaiai??. E?euee?noue AeIE-OeIA, yea aecia/aeanue ca iaoiaeii AeIE-a?a?eaeecaoe??, ciaioeeanue ?c 10-2 aei 10-5 iea/i?ia. O a?oi? oai?eo, yeeo e?eoaaee eaoa?iiii, a?aei?/aeinue a??ia?aeia i?aeaeuaiiy e?eueeino? aaiiaeia?io c 104±2,7 a/e aei 111±1,8 a/e (?<0,01), o?iiaioeeo?a – c 181,3±1,3o109/e aei 196,2±2,4o109/e (?<0,01), oei /anii a eiio?ieuei?e a?oi? oe? iieacieee ia o?eueee ia iaaoee ci?ie, aea iaa?oue iai?/aeanue oaiaeaioe?y aei cieaeaiiy ??aiy aaiiaeia?io (105,0±1,7 a/e ? 103,6±2,1 a/e, ?>0,05).

Eiiieaenia oa?ai?y c aeei?enoaiiyi eaoa?iio iaea ?ioiiiiaeoethth/ee
aieea ia ee?oeiio eaieo ?ioi?oaoo, i?aeaeuoth/e iecuee? oa iiieaeath/e
aenie? iieacieee, ii?iae?coth/e ni?aa?aeiioaiiy e?eueeino? noaiiioeyoe?e
e?ioioeeo?a, i?e oeueiio iaea?eueo aeoeaiei aoa c??no ??aiy O-oaeia??a
(29,0±1,1 % ? 38,5±1,3 % a?aeiia?aeii, ?<0,001). I?ae aieeaii e?eoaaiiy noaeeny ci?ie o ai?no? ne?iaaoeiaeo ?ioiiaeiaoe?i?a. Iiieceeenue ??ai? Ig A ? Ig G (P<0,01 ? P<0,05 a?aeiia?aeii). Nooo?aeo ci?i noiniaii Ig M ia a?aei?/aii. O a?oi? oai?eo, o yeeo i?ia?aeiith aoea iaa?ieia?/ia neiioiiaoeea, i?ney eaoa?iiioa?ai?? ae?aaeaia iiceoeaia ee?i?/ia aeeiai?ea ia a?aei?/aeanue, ui iiaeia iiynieoe ?aii?i ?io?eoaaiiyi ieiaeo oa iaiai?ioieie i?aai?/ieie ci?iaie a OeIN. Iaeiae i?ney i?iaaaeaiiy eaoa?iiioa?ai?? o 3 oai?eo (18,8 %) OeIE o e?eai?? ia aeyaeaii. O 5 oai?eo (31,3 %) c o?eaaeith noaoaa?eeueiith oaiia?aoo?ith ia oe? e?eai?ii-a?ia?oaic?eiiai neiae?iio no?eei ii?iae?coaaeanue oaiia?aoo?ia ?aaeoe?y. O 1 oai?iai (6,3 %) c i?e?iaeaeaiith OeIA? oa iai?ia?oii, i?e o?eaae?e a?aenooiino? naiaoe?? e?eai?o, i?ney e?eoaaiiy eaoa?iiii OeIE o e?eai?? ia aecia/aeenue, cia/ii ciaioeany ieaioeeoic c ianooiiith naiaoe??th e?eai?o. A??on-niaoeeo?/iee aoaeo o 6 oai?eo (37,5 %) oe??? a?oie aeyaeyany cieaeaiiyi eiioeaio?aoe?? AeIE-OeIA c 10-2 iea/i?ia aei 10-4 iea/i?ia. O 5 oai?eo c ae?aaeaiith iaa?ieia?/iith neiioiiaoeeith a eiiieaeni?e oa?ai?? ?acii c eaoa?iiii aoei i?ecia/aii a??ieaen. A?aei?/aii ciaioaiiy ?aa?ano iaa?ieia?/ii? neiioiiaoeee, ae?oae aoei aeienaii aeiaeiio c ii?iaeueiith oaiia?aoo?ith o?ea, noaa?e?caoe??th a?oaeueieo ooieoe?e, ciaioaiiyi aiaieuaai? iaa?ieia?/ii? neiioiiaoeee. Aoei onoiaii noaeiiiee neiae?ii. O oai?eo c iiiiioeeaiciiiae?aiei neiae?iiii, yeeo e?eoaaee eaoa?iiii, a?aei?/aeanue a?eueo no?eea ii?iae?caoe?y oaiia?aoo?e o?ea, i?ae a eiio?ieuei?e a?oi? (?<0,05). I?ney ia?oiai eo?no e?eoaaiiy o 3 ae?oae ?c 7 aioeaai o neei? ia aeyaeyany. I?ney ae?oaiai eo?no e?eoaaiiy o 5 oai?eo ?c 7 ?acoeueoaoe aeine?aeaeaiiy neeie ia aeyaeaiiy OeIE aoee iaaaoeaieie. O oai?eo c iiiiioeeaiciiiae?aiith oi?iith OeIA? niinoa??aaeinue cieaeaiiy caaaeueii? e?eueeino? O-e?ioioeeo?a ia?aaaaeii ca ?aooiie NAe8. I?ae aieeaii e?eoaaiiy eaoa?iiii ?ioiieia?/i? iieacieee iie?aueeenue. Ca?eueoeeanue e?euee?noue O-caaaeueieo e?ioioeeo?a (c 44,7±2,3 % aei 55,7±1,8 %, ?<0,001), a oaeiae ?o noaiiioeyoe?e (NAe4 c 33,3±1,1 % aei 38,7±0,9 %, ?<0,001). A?aeiia?aeii i?aeaeueeinue /enei NAe8 c 12,7±1,5 % aei 19,5 ± 1,08 % (?<0,001). Ni?aa?aeiioaiiy NAe4/NAe8 i?ney e?eoaaiiy ciaioeeinue ? neeaei 1,5. Aeoeai?noue iaoo?aeueieo e?ea??a (IE) o oe?e a?oi? oai?eo, ui aoea i?aeaeuaia (18,5±1,3 %), aeyaeea oaiaeaioe?th aei ii?iae?caoe?? i?ney e?eoaaiiy (14,6±1,4 % ?>0,05). O ai?no? ne?iaaoeiaeo ?ioiiaeiaoe?i?a
iniiaieo eean?a ia aeyaeaii nooo?aeo ci?i.

Aoaeoeai?noue i?aia?aoo aaaaoi a /iio caeaaeaea a?ae no?ie?a
?io?eoaaiiy aeeoeie. Aiia aoea iaeiaioith i?e ?aiiueiio ?io?eoaaii?
ieiaeo, oiaoi i?e aioo??oiueioo?iai?e ?ioaeoe??. O ca’yceo c oeei ie
aeae?eeee oaeoi?e, ye? aieeaathoue ia aoaeoeai?noue eaoa?iiioa?ai??
(noaia 2).

Aoaeoeai?noue oa?ai?? i?e OeIA? a a?eueoino? aeiaaee?a aecia/aeanue
no?ieii ?? ii/aoeo. Ine?eueee ia?o? ee?i?/i? neiioiie caoai?thaaiiy
iiaeooue i?iyaeoeny i?ney ia?iaeaeaiiy ia a?ae?aco, a ia 2-4-io i?nyoe?
aeeooy, an?o iiaiia?iaeaeaieo c iani?eyoeeaei i?aii?a?aeiei oiiii ?
iani?eyoeeaei aeooa?nueeei aiaiiacii iaoa??a, iaiao?aeii ianoaaeeoe ia
a?oio o?ainieaoeaioa?ieo ?ioaeoe?e, o oiio /ene? OeIA?, uia yeiiiaa
?ai?oa ?icii/aoe eiiieaenio, niaoeeo?/io oa?ai?th ?c canoinoaaiiyi
i?ioea??onieo i?aia?ao?a.

Ae?oyi c ee?i?/ieie neiioiiaie OeIA? iieacaii i?ecia/aiiy i?ioea??onii?
oa?ai?? ?c canoinoaaiiyi eaoa?iio a ii?aeiaii? c a??ieaenii. Ae?oyi,
?io?eiaaiei OeIA aac ee?i?/ieo i?iya?a, aea c eiai eaai?aoi?iei
i?aeoaa?aeaeaiiyi aeoeaiino? ?ioaeoe?eiiai i?ioeano, iaiao?aeii
i?iaiaeeoe e?eoaaiiy c aeei?enoaiiyi ?ioiiiiaeoethth/iai caniao, iaeiei
c yeeo iiaea aooe eaoa?ii.

Iani?eyoeeaee aieea ?io?eoaaiiy OeIA ia ia?aa?a ?ioaeoe?eii? iaoieia??
o ae?oae i?aeoaa?aeaeoaaany oaeiae aeaieie ?noi??e oai?iae ?
iaoiii?oieia?/ieo aeine?aeaeaiue 65 ae?oae a?eii a?ae 1 i?nyoey aei 1
?ieo 2 i?nyoe?a, ye? iiia?ee a IAe?EE i. Oa?eiaa i?ioyaii 1992-1996 ??.
Na?aae iiia?eeo ia?aaaaeaee ae?oe ia?oeo 3 i?nyoe?a aeeooy – 32 aeeoeie
(49,2 %).

I?e aeeoo? ia OeIA? aaeaeiny ianoaaeeoe 18 ae?oae. O 11 c ieo aeyaeaii
OeIE: a inaaeeao neeie oa na/? – o 2-o, o?eueee a neei? – o 3-o, o?eueee
a na/? – o 6 oai?eo. Niaoeeo?/i? aioeoeeoiiaaaeia??oni? aioeo?ea
aeyaeaii o 5 ae?oae. I?e ioi?ieaii? caeeth/iiai ee?i?/iiai ae?aaiico
o?eueee o 2 oai?eo OeIA? aeciaii iniiaiei caoai?thaaiiyi, o 11 – ye
noiooith iaoieia?th. I?ae oei, i?e iaoieiaiaiioii?/ieo aeine?aeaeaiiyo o
33 ae?oae ciaeaeaii ii?oieia?/i? ci?ie a ??cieo i?aaiao, ye? aeacothoue
ia OeIA?, aea ?o iaiiaeeeai iiynieoe o?eueee iniiaiei caoai?thaaiiyi
(iai?ia?o, eeoeiaa ?ioaeoe?y).

Ii?yae c oeei o 15 ae?oae oe??? a?oie a eaaaiyo ? o 8 ae?oae a ?ioeo
i?aaiao ciaeaeaii e?ioia?no?ioeeoa?i? ?io?eueo?aoe, ?iiae? c
i??ei?aeieie ee?oeiaie, ui iiaei aooe coiiaeaii ae??th AeIE-a??on?a,
cie?aia OeIA.

AENIIAEE

1. Ae?oe, ye? ia?iaeeeenue a?ae iaoa??a c iani?eyoeeaei ia?aa?aii
aaa?oiino? oa iieia?a (aeeeaei? a ieioeiio, oieneeice oa caa?ica
ia?a?eaaiiy aaa?oiino?, ia?aae/ani? iieiae), oi?iothoue a?oio ?eceeo
aioo??oiueioo?iaiiai oa ?io?aiaoaeueiiai ?io?eoaaiiy OeIA.

2. O ae?oae, ye? ciaoiaeeeenue o Oa?e?anuee?e iaeani?e aeeoy/?e
?ioaeoe?ei?e ee?i?/i?e e?ea?i?, ?io?eiaai?noue OeIA i?e iayaiino?
iaa?ieia?/ii? neiioiiaoeee neeaea 39,8 %, o?aaeaiiy oeoieiai-eeoeiaiai
o?aeoo – 51,5 %, iiiiioeeaiciiiae?aii? oi?ie caoai?thaaiiy – 8,7 %.

3. O ae?oae c aioo??oiueioo?iaiith OeIA?, ia a?aei?io a?ae
iinoiaoaeueii?, niinoa??aaeenue a?iio?io?y 1-3-ai nooiaiy, ??ci?
o?aaeaiiy OeIN (a?ae neiae?iio i?eai?/aiiy ?? aei ?icaeoeo
oeeoiiaaaeia??oniiai iai?iaiaioeaoae?oo), aiai?y, o?iiaioeeoiiai?y.

4. Ia i?aenoaa? aeaieo ee?i?/ieo aeine?aeaeaiue ? aeniei/ooeeaeo
niaoeeo?/ieo iaoiae?a eaai?aoi?ii? ae?aaiinoeee (oeeoineii?y, ?OA,
AeIE-a?a?eaeecaoe?y) aeae?eaii ee?i?ei-iaoiaaiaoe/i? oi?ie OeIA?:
aino?a, o?ii?/ia, ?aaeoeaiaaia, noaee?i?/ia (eaoaioia).

5. Aioo??oiueioo?iaia o?aaeaiiy OeIN, yea aoei ae?aaiinoiaaii o 27,7 %
ae?oae ?c a?oie ?eceeo, iae/ano?oa aeyaeyeinue cao?eieith ineoiiioi?iiai
?icaeoeo (92,3 %), a?ia?oaic?eii-a?ae?ioeaoaeueiei (80,8 %) ? noaeiiiei
(69,2 %) neiae?iiaie. O a?eueoino? oai?eo (80,8 %) iaee i?noea
noi?iiaai? i?aai?/i? o?aaeaiiy (?icoe?aiiy oeoii/eiai? nenoaie iiceo,
ia?aaaio?eeoey?i? e?noe, aiaioeaoae?y). I?ia?aeieie a ioe?ioe?
no?oeoo?ieo ci?i ia?aio?ie iiceo ? eiai ii?iaeieiieo nenoai aoee
oeueo?acaoeiaa ae?aaiinoeea ? I?O aieiaiiai iiceo.

6. Iaeiei c i?iya?a aeoeaii? OeIA? o ae?oae ?aiiueiai a?eo ? noaeiiiee
neiae?ii, yeee niinoa??aaany o 27,2 % oai?eo. Anoaiiaeaii ei?aeyoe?eio
caeaaei?noue i?ae aeyaeaiiyi OeIE a inaaeeao neeie oa iayai?noth
noaeiiiiai neiae?iio.

7. O oai?eo, ?io?eiaaieo OeIA, c o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo a
30,3 % aeiaaee?a OeIA? ia?aa?aaea o aeaeyae? iiii?ioaeoe?? ? aoea
ao?ieia?/iei oaeoi?ii aano?iaioa?ieie?oo, o 58 % oai?eo – ye
i?eno-?ioaeoe?y, iaoyaeoth/a ia?aa?a AE?, oa a 11,7 % niinoa?aaeaiue
ae?aaiinoiaaii noaee?i?/io oi?io OeIA?, yea ia ia? ae?aaeaiiai aieeao ia
iniiaia caoai?thaaiiy.

8. I?e iiiiioeeaiciiiae?ai?e oi?i? OeIA?, ia a?aei?io a?ae ?ioaeoe?eiiai
iiiiioeeaico, oiicee?o ? e?ioaaeaiiiao?y aoee ae?aaeai? a iacia/i?e
i???, a iiiioeeoico ia aeyaeaii. Oey oi?ia ?ioaeoe?? iaea aino?ee
ia?aa?a aai o?ii?/iee c ianooiiith ?aaeoeaaoe??th OeIA.

9. Aiae?c ?aioaaiia?ai i?aai?a a?oaeii? ee?oee aeicaieea o a?eueoino?
oai?eo ia OeIA? (97,1 %) aeyaeoe caaaa/aiiy ? iineeaiiy eaaaiaaiai
iaethiea – aeaia?/ia oa aeeoocia, a?eueo ae?aaeaia a iaae?aeueieo
a?aeae?eao, ci?ie ei?ai?a eaaaiue (o 37,1 %), aiaieuaa? iiaaiii??
??ciiai nooiaiy ae?aaeaiiy (o 60 %), aoaeaeoace (o 37,1 %). Ci?iaiee
eaaaiaaee iaethiie caa??aaany i?ioyaii i?nyoey i?ney ia?aianaiiai
caoai?thaaiiy.

10.  C o?aooaaiiyi aiaiianoe/ieo, ee?i?/ieo ? ii?oieia?/ieo aeaieo o
ae?oae, ye? iiia?ee a?ae ?ioaeoe?eii? iaoieia??, ?aaeueia /anoioa OeIA?
(51 %) aeyaeeanue aeuith, i?ae aecia/aeanue o ee?i?/i?e i?aeoeoe? (20
%).

11.  Iaea?eueo aeinooiiei oa ?ioi?iaoeaiei o ae?aaiinoeoe? OeIA? ?
oeeoineii?/iee iaoiae aeine?aeaeaiiy. Eiai /ooeea?noue neeaea 75 %,
niaoeeo?/i?noue – 93 %, a??ia?aei?noue – 84 %.

12.  Anoaiiaeoe caeeth/iee ae?aaiic OeIA? iiaeia ia i?aenoaa? iiceoeaieo
?acoeueoao?a ia iaioa ye aeaio iaoiae?a eaai?aoi?ii? ae?aaiinoeee:
oeeoineii?y + ?OA aai ?OA + AeIE-a?a?eaeecaoe?y. Aeniei?ioi?iaoeaiei
oanoii, yeee aeicaiey? aeyaeoe noaee?i?/io oi?io OeIA?, ? iaoiae
AeIE-a?a?eaeecaoe??.

13.  Onoaiiaeaii oa?aiaaoe/io aoaeoeai?noue eaoa?iio i?e OeIA? o ae?oae,
yea i?iyaeyeanue ciaioaiiyi ai?y/eiaiai ia??iaeo, oaeaeoith
ii?iae?caoe??th aeii?iaeiaiue, i?aeaeuaiiyi iieaciee?a aaiiaeia?io ?
o?iiaioeeo?a. I?aia?ao ni?eya ii?iae?caoe?? ni?aa?aeiioaiiy
noaiiioeyoe?e O-e?ioioeeo?a o e?ia?, i?aeaeuoth/e /enei O-oaeia??a.
Aoaeoeai?noue eaoa?iio caeaaeaea a?ae nooiaiy ?iciianthaeaeaiino?
?ioaeoe?eiiai i?ioeano ? no?ie?a ?io?eoaaiiy aeeoeie, oa aoea iaeiaioith
o ?ac? aioo??oiueioo?iaiiai ?io?eoaaiiy.

Nienie ?ia?o, iioae?eiaaieo ca oaiith aeena?oaoe??

1. Oiaeae E.A., Iaaao O.E. ?ieue oeeoiiaaaeee a no?oeoo?a eaoaeueiinoe
aiieiuo iaieiaeoia o aeaoae ?aiiaai aic?anoa // Aanoiee i?iaeai
nia?aiaiiie iaaeeoeeiu. — 1995. — ? 4. — N. 128-131.

2. Oiaeae E.A., Iaa?o O.?., Ni?eyinueea I.A., Iaea?aiei A.Ae. Ei?/? o
ae?oae ?aiiueiai a?eo ye i?iya oeeoiiaaaeia??onii? ?ioaeoe?? a
aeieia?/ii iani?eyoeeaeo oiiaao // Iaae?ao??y, aeooa?noai oa
a?iaeieia?y. — 1996. — ? 3. — N. 19-21.

3. Oiaeae E.A., Iaaao O.E. A?iaeaeaiiay oeeoiiaaaeiae?oniay eioaeoeey n
ii?aaeaieai aieiaiiai iicaa o ?aaaiea 5 ianyoeaa // Iaaeeao?ey. — 1997.
— ? 3. — N. 101-102.

4. Oiaeae E.A. Oeeoiiaaaeiae?oniay eioaeoeey o aeaoae // Oa?ueeianeee
iaae. aeo?iae. — 1997. — ? 1. — N. 44-47.

5. Oiaeae E.A., Ni?eyinueea I.A., Ia?aiio N.Ae., Iai/aiei E.I. E?eoaaiiy
oeeoiiaaaeia??onii? ?ioaeoe?? o ae?oae // ?ioaeoe?ei? oai?iae. — 1997. —
? 3. — N. 51-52.

6. Oiaeae E.A. No/ani? iiaeyaee ia aa?iana??oni? ?ioaeoe??
// ?ioaeoe?ei? oai?iae. — 1997. — ? 4. — N. 42-44.

7. Oiaeae E.A. Oa?iaeioa?aiey aa?ianae?oniuo eioaeoeee
// Iaaeaeoia?iaeiue iaae. aeo?iae. — 1997. — ? 4. — N. 57-59.

8. E?aiiee ?.I., Oiaeae E.A., Ai?oiee I.I., A?ea E.I.
Ee?i?ei-?aioaaiieia?/i? i?iyae ci?i eaaaiue i?e oeeoiiaaaeia??oni?e
?ioaeoe?? o ae?oae ?aiiueiai a?eo // Oe?a?inueeee ?aae?ieia?/iee
aeo?iae. — 1998. — ? 1. — N. 27-29.

9. Oiaeae E.A. Nia?aiaiiua aniaeou oeeoiiaaaeiae?oniie eioaeoeee o
aeaoae // Oe?a?inueeee a?niee ineoiiaa?ieia???. — 1997. — o.5 aei. 3
(15). — N. 115-116.

10.  Oiaeae E.A. Oeueo?acaoeiaa aeine?aeaeaiiy oa iaai?oii-?aciiainia
oiiia?ao?y o?aaeaiue aieiaiiai iiceo i?e oeeoiiaaaeia??oni?e ?ioaeoe?? o
ae?oae // Oe?a?inueeee ?aae?ieia?/iee aeo?iae. — 1998. — ? 3. —
N. 269-271.

11.  Oiaeae E.A. Iiiiioeeaiciiiaeiaiay oi?ia oeeoiiaaaeiae?oniie
eioaeoeee o ?aaaiea ?aiiaai aic?anoa // Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu. — 1998. — ? 21. — N. 74-75.

12. Iai/aiei E.A., Oiaeae E.A., Iiiiaa E.A., A?aaa?ue A.A. Iiiaieeeee
aa?ian: nia?aiaiiua aeaiiua i eeeieei-ii?oieiae/aneii iieeii?oecia.
Ne?eieia aioeaaiia aa?ianae?onia 1 e 2 oeiia o aieueiuo ?acee/iiai
i?ioeey // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. — 1998. — ? 15. —
N. 37-40.

13.  Oiaeae E.A., Aiae?ae/ei I.A., Iai/aiei E.I., Ee?e/aiei ?.?.
Iiaeeeaino? eaai?aoi?ii? ae?aaiinoeee OeIA? // ?ioaeoe?ei? oai?iae. —
1998. — ? 4. — N. 47-51.

14.  Oiaeae E.A., Iaa?o O.?., E?aia??a N.I. Oeeoiiaaaeia??onia ?ioaeoe?y
o ae?oae // Iaae?ao??y, aeooa?noai oa a?iaeieia?y. — 1998. — ? 4. —
N. 47-50.

15.  Oiaeae E.A. Ii?aaeaiea oeaio?aeueiie ia?aiie nenoaiu i?e
oeeoiiaaaeiae?oniie eioaeoeee o aeaoae // Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu. -1999. — ? 7. — N. 60-63.

16.  Iai/aiei E.A., Ee?e/aiei E.E., Eo/ia E.TH., Oiaeae E.A. N?aaenoaa
oa?aiee e i?ioeeaeoeee aa?ianae?oniuo eioaeoeee. — Oa?ueeia: ?EI
“I?eaeiae”, 1999. — 90 n.

17.  Iai/aiei E.A., Oiaeae E.A., Ee?e/aiei E.E. Aicaoaeeoaee
aa?ianae?oniuo eioaeoeee e iaeaieaa aaaeiua eeeie/aneea i?iyaeaiey o
/aeiaaea // I?iaeci?. — 1999. — ? 10. — N. 28-29.

18.  Oiaeae E.A., Iai/aiei E.I., Ee?e/aiei ?.?. Aaiii-?iaeaia?iee
aeueoa-2-?aeiia?iaioiee ?ioa?oa?ii o eiiieaeniiio e?eoaaii?
oeeoiiaaaeia??onii? ?ioaeoe?? // Ee?i?/ia oa?iaoe?y. — 1999. — ?  2. —
N. 102-104.

19.  Oiaeae E.A. Nia?aiaiiua i?aaenoaaeaiey i oeeoiiaaaeiae?oniie
eioaeoeee o aeaoae // Iaoa?eaeu thaeeaeiie eiioa?aioeee, iinayuaiiie
75-eaoeth eaoaae?u eioaeoeeiiiuo aieaciae OEOA, i?eeiaeaiea e «School of
Fundamental Medicine Journal», March 1999, Vol.5, ?1, P.105-106.

20.  Oiaeae E.A. Oeeoiiaaaeey a eioaeoeeiiiie iaoieiaee o aeaoae // ??
iaoeeiiaeueiue eiia?ann aianoaceieiaia Oe?aeiu: Oac. aeiee. — Oa?ueeia,
1996. — N. 110.

21.  Oiaeae E.A., Iaaao O.E., Niaeyineay I.A. Eeeieei-eaai?aoi?iua
aniaeou oeeoiiaaaeiae?oniie eioaeoeee o aeaoae ?aiiaai aic?anoa // Eaeae
E.E. Ia/ieeiaa e ?acaeoea nia?aiaiiiai anoanoaiciaiey: Iaoa?eaeu
iaaeaeoia?iaeiie iao/iie eiioa?aioeee. — Oa?ueeia. — 1995. — N. 331-332.

22.  Oiaeae E.A., Iaea?aiei A.Ae. OeIA? a no?oeoo?? aino?eo
aano?iaioa?ieie?o?a o ae?oae ia?oiai i?a?ieo aeeooy // 13-e c’?cae
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a,
ia?aceoieia?a: Oac. aeii. — A?iieoey. — 1996. — N. 79.

23.  Oiaeae E.A., Iaa?o O.E., Iaea?aiei A.Ae., Ni?eyinueea I.A.
Oeeoiiaaaei-a??onia ?ioaeoe?y o ae?oae // 13-e c’?cae Oe?a?inueeiai
iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a, ia?aceoieia?a: Oac.
aeii. — A?iieoey. — 1996. — N. 304-305.

24.  Oiaeae E.A., Iaa?o O.E. Aea/aiiy ?iciianthaeaeaiino? OeIA? na?aae
oai?eo iai?ia?oii a ?aiiueiio aeeoy/iio a?oe? // 13-e c’?cae
Oe?a?inueeiai iaoeiaiai oiaa?enoaa i?e?ia?ieia?a, ai?aeai?ieia?a,
ia?aceoieia?a: Oac. aeii. — A?iieoey. — 1996. — N. 274.

25.  Oiaeae E.A., Niaeyineay I.A., Iai/aiei E.I., Eo/ia E.TH.
Yooaeoeaiinoue eaai?aoi?iie aeeaaiinoeee OeIAE o aeaiuei n ioyaiuaiiui
aeooa?neei aiaiiacii // Eaeae E.E. Ia/ieeiaa e ?acaeoea nia?aiaiiiai
anoanoaiciaiey: Iaoa?eaeu iaaeaeoia?iaeiie iao/iie eiioa?aioeee.. —
Oa?ueeia. — 1995. — N. 279-280.

26.  Oiaeae E.A., Iai/aiei E.I., Iaa?o O.?. Oeeoiiaaaeia??onia
?ioaeoe?y: iiaeeeaino? ae?aaiinoeee e?eoaaiiy ia no/aniiio aoai? // 5-e
c’?cae ?ioaeoe?ii?no?a a Oe?a?i?: Oac. aeii. — Oa?iii?eue, 1998. —
N. 347-348.

27.  Oiaeae E.A., Ni?eyinueea I.A. Ioe?iea niaoeeo?/ieo iaoiae?a
eaai?aoi?ii? ae?aaiinoeee OeIA? o ae?oae // Iao. iaoe.-i?aeo. eiio. —
Noie — Oa?iii?eue. — 1997. — N. 32-35.

28.  Oiaeae E.A., Iaea?aiei A.Ae. Iniaaiiinoe eeeie/aneiai oa/aiey
ino?uo eeoa/iuo eioaeoeee o aeaoae ia?aiai aiaea aeecie // Iiaia a
iaaeeoeeia: Nai?iee iao/iuo o?oaeia. — Oa?ueeia, 1994. — N. 80.

29.  Oiaeae E.A., Iaea?aiei E.E., ?uaaeei A.I., Cae?aaneee I.I.
Iniaaiiinoe oa?aiee eioaeoeeiiiuo aieueiuo a iino?aaieiaoeeiiiii
ia?eiaea // Iaaeeoeeia. Yenia?eiaio. I?aeoeea: na. iao/. noaoae. —
Oa?ueeia, 1994. — N. 119-121.

30.  Oiaeae E.A., Iaea?aiei E.E., ?uaaeei A.I., Cae?aaneee I.I.
Iniaaiiinoe eeeie/aneiai oa/aiey oeeoiiaaaeee o aeaoae //  Aeooaeueiua
aii?inu iee?iaeieiaee, yieaeaieieiaee e eiioiieiaee eioaeoeeiiiuo
aieaciae: Oac. aeiee. iao/.-i?aeo. eiio. — Oa?ueeia, 1993. — N. 228.

31.  Oiaeae E.A. I?ioeeaeoe/aneea aniaeou oeeoiiaaaeiae?oniie eioeoeee
// Aeieiae/aneia aeaenoaea oaeoi?ia ie?oaeathuae n?aaeu: Na. iao/.
o?oaeia. — Oa?ueeia, 1996. — N. 123-124.

32.  Oiaeae E.A., Iaea?aiei E.E., Oeoiiiaa E.A., E?e/aaneay A.TH.
Cia/aiea OeIAE a ?acaeoee noaei?iaeiiai neiae?iia o aeaoae
// Iee?iaeieiaey, yieaeaieieiaey e eeeieea eioaeoeeiiiuo aieaciae: Na.
iao/. noaoae. — Oa?ueeia, 1993. — N. 85-88.

33.  Oiaeae E.A., Aeaeaeaeia Y.A., Oeoiiiaa E.A. Ninoiyiea
oiieieeoa/iiai ieuaaa?aiey i?e OeIAE o aeaoae // Iee?iaeieiaey,
yieaeaieieiaey e eeeieea eioaeoeeiiiuo aieaciae: Na. iao/. noaoae. —
Oa?ueeia, 1993. — N. 88-91.

34.  Oiaeae E.A., Aeaeaeaeia Y.A., Iaea?aiei E.E. Eiaeiua i?iyaeaiey i?e
OeIAE o aeaoae // Nia?aiaiiua aniaeou aeeaaiinoeee, eeeieee e
i?ioeeaeoeee eiaeiuo, aaia?e/aneeo e ae?oaeo eioaeoeeiiiuo caaieaaaiee
(NIEAe): Oac. aeiee. iao/.-i?aeo. eiio. — Oa?ueeia, 1991. — N. 61.

35.  Oiaeae E.A., Aeaeaeaeia Y.A., Iaea?aiei E.E. Ia?ooaiea ooieoeee
aeaeoaei/ii-eeoa/iiai o?aeoa e eo ei??aeoeey i?e o?iie/aneie OeIAE o
aeaoae // O?iie/aneia ainiaeaiea e caaieaaaiey i?aaiia ieuaaa?aiey:
Iaoa?eaeu iao/i.-i?aeo. eiio. — Oa?ueeia, 1991. — N. 158.

Aiioaoe?y

Oiaeae E.A. Oeeoiiaaaeia??onia ?ioaeoe?y o ae?oae (ee?i?ea,
ae?aaiinoeea, e?eoaaiiy). — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca
niaoe?aeuei?noth 14.01.13 – ?ioaeoe?ei? oai?iae. Iaoeiai-aeine?aeiee
?inoeooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai,
Ee?a, 1999.

Iaoith ?iaioe aoei aeine?aeeoe ee?i?ei-iaoiaaiaoe/i? iniaeeaino? OeIA?
o ae?oae, iie?aueoe ?? ae?aaiinoeeo oa ?ic?iaeoe iioeiaeueio oaeoeeo
ao?ieia?/ii? oa?ai??. I?ae niinoa?aaeaiiyi aoei 516 oai?eo a?eii a?ae 1
i?nyoey aei 12 ?ie?a. Aia?oa aeaii ee?i?/io ioe?ieo canoinoaaiiy
iaoiae?a oeeoineii??, ?OA ? AeIE-a?a?eaeecaoe?? aeey ae?aaiinoeee OeIA?
o ae?oae. Iieacaii aenieo ?ioi?iaoeai?noue iaoiaeo AeIE-a?a?eaeecaoe??
oa eiai ni?iiiaei?noue aeyaeyoe noaee?i?/io oi?io OeIA?.

Anoaiiaeaii, ui ?io?eiaai?noue OeIA oai?eo c iaa?ieia?/iith
neiioiiaoeeith noaiiaeea 39,8 %, o?aaeaiiyi oeoieiai-eeoeiaiai o?aeoo –
51,5 %, iiiiioeeaiciiiae?aiith oi?iith caoai?thaaiiy – 8,7 %. Aeae?eaii
?yae ee?i?ei-iaoiaaiaoe/ieo oi?i OeIA?: aino?o, o?ii?/io, ?aaeoeaiaaio ?
noaee?i?/io (eaoaioio). Aecia/aii ee?i?/i? i?iyae a?iaeaeaiiai o?aaeaiiy
OeIN ? no?oeoo?i? ci?ie aieiaiiai iiceo (ca aeaieie iaai?oii-?aciiainii?
oiiia?ao??), ca’ycie noaeii ?c OeIA.

Ia i?aenoaa? eiiieaeniiai aeine?aeaeaiiy oai?eo ?c ee?i?/iith ea?oeiith
AE? aia?oa aeyaeaii aano?iaioa?ieie?oio oi?io OeIA? oa iienaii ??
ee?i?/i? i?iyae, aea/aii iniaeeaino? ii?aeiaiiy OeIA? c AE?.
Aeine?aeaeaii ee?i?/i? oa ?aioaaiieia?/i? iniaeeaino? o?aaeaiiy eaaaiue
i?e OeIA?, eiinoaioiaaii caa?aaeaiiy ci?iaiiai iaethiea oeueiai i?aaia o
?aeiiaaeanoeaio?a.

Aia?oa iaa?oioiaaii oa?aiaaoe/io aoaeoeai?noue eaoa?iio i?e OeIA? o
ae?oae, eiai i?ioea??onio oa ?ioiiiiaeoethth/o ae?th.

Eeth/ia? neiaa: oeeoiiaaaeia??onia ?ioaeoe?y, ee?i?/i? i?iyae,
ae?aaiinoeea, e?eoaaiiy.

Aiiioaoeey

Oiaeae E.A. Oeeoiiaaaeiae?oniay eioaeoeey o aeaoae (eeeieea,
aeeaaiinoeea, ea/aiea). — ?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie aeieoi?a iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.13 – eioaeoeeiiiua aieacie.
Iao/ii-enneaaeiaaoaeueneee einoeooo aieaeaieieiaee e eioaeoeeiiiuo
aieaciae ei. E.A. A?iiaoaaneiai, Eeaa, 1999.

Oeaeueth ?aaiou yaeeinue eco/aiea eeeieei-iaoiaaiaoe/aneeo iniaaiiinoae
OeIAE o aeaoae, oeo/oaiea aa aeeaaiinoeee e ?ac?aaioea iioeiaeueiie
oaeoeee yoeio?iiiie oa?aiee. Iiae iaaethaeaieai iaoiaeeeinue 516
aieueiuo a aic?anoa io 1 ianyoea aei 12 eao. Aia?aua aeaia eeeie/aneay
ioeaiea i?eiaiaiiuo iaoiaeia oeeoineiiee, EOA, AeIE-aea?eaeecaoeee aeey
aeeaaiinoeee OeIAE o aeaoae. Iieacaia aunieay eioi?iaoeaiinoue iaoiaea
AeIE-aea?eaeecaoeee e aai aiciiaeiinoue auyaeyoue noaeeeie/aneoth oi?io
OeIAE.

Onoaiiaeaii, /oi eioaoee?iaaiiinoue OeIA aieueiuo n iaa?ieiae/aneie
neiioiiaoeeie ninoaaeea 39,8 %, ii?aaeaieai aeaeoaei/ii-eeoa/iiai o?aeoa
– 51,5 %, iiiiioeeaiciiiaeiaiie oi?iie caaieaaaiey – 8,7 %. Auaeaeaiu
eeeieei-iaoiaaiaoe/aneea oi?iu OeIAE: ino?ay, o?iie/aneay,
?aaeoeae?iaaiiay e noaeeeie/aneay (eaoaioiay). Ii?aaeaeaiu eeeie/aneea
i?iyaeaiey aioo?eoo?iaiiai ii?aaeaiey OeIN e no?oeoo?iua eciaiaiey
aieiaiiai iicaa (ii aeaiiui iaaieoii-?aciiainiie oiiia?aoee),
acaeiinaycue noaei?iaeiiai neiae?iia n OeIA.

Ia iniiaaiee eiiieaeniiai ianeaaeiaaiey aieueiuo n eeeie/aneie ea?oeiie
IEE aia?aua auyaeaia aano?iyioa?ieieeoe/aneay oi?ia OeIAE e iienaiu aa
eeeie/aneea i?iyaeaiey, eco/aiu iniaaiiinoe ni/aoaiiiai oa/aiey OeIAE e
IEE. Enneaaeiaaiu eeeie/aneea e ?aioaaiieiae/aneea iniaaiiinoe
ii?aaeaiey eaaeeo i?e OeIAE, onoaiiaeaii nio?aiaiea eciaiaiiiai
eaai/iiai ?enoiea o ?aeiiaaeanoeaioia.

Aia?aua ii?aaeaeaia oa?aiaaoe/aneay yooaeoeaiinoue eaoa?iia i?e OeIAE o
aeaoae, aai i?ioeaiae?oniia e eiioiiiiaeoee?othuaa aeaenoaea.

Eeth/aaua neiaa: oeeoiiaaaeiae?oniay eioaeoeey, eeeie/aneea i?iyaeaiey,
aeeaaiinoeea, ea/aiea.

Annotation

L.A. Khodak. Cytomegalovirus Infections in Children (clinic,
diagnostics, treatment). – Manuscript.

Thesis for academic deqree of doctor of Science (Medicine) in Specialty
14.01.13 – infections diseases. L.V. Gromashevsky – Scientific Research
Institute of Epidemiology and infections disease, Ministry of Health of
Ukraine, Kiev, 1999.

The object of this work is studying of clinical and patogenetical
particularities of CMVI in children, improving its diagnostics and
working out optimum tactics of ethiothropic therapy.

516 patients from 1 mouth to 12 years old were observed.

Clinical estimation of applicated methods, such as: cytoscopy,
immunological fermental analysis and deoxyribonucleic acid gibridization
(DNA) for diagnostics of CMVI in children was represented for the first
time.

High informativity of DNA-gibridization and its possibilities to
indicate the subclinical form of CMVI was observed.

For improving the informativity of specific methods of laboratory
diagnostics and estimation of the activity of infection process, the
simultenions use of not less than two methods of laboratory diagnostics
was recommended. It was determined that the infectioning of CMVI
patients with neurological symptoms was 39,8 %, with the damage of
alimentary canal – 51,5 % and with mononucleosis from of CMVI – 8,7 %.

Clinical pathogenetic forms of CMVI were distinguished. They are: acute,
chronical, reactivative and subclinical (latentive) one.

Clinical manifestations of congenital damage of CNS and structural
changes in the brain (according to the data of MRT) were estimated.
Interconnection between convulsive syndrome and presence of CMV was
described.

Clinical properties of acute intestine infection were studied in
children with CMV.

In clinical investigation first was estimated gastroenterocolitic from
of CMVI. Here we could observe the combined course of CMVI and acute
intestinal infections that caused more prolonged and intensive clinical
symptoms and worsening of the prognosis of the disease.

Clinical and x-ray particularities of damage of the lungs in CMVI were
investigated. Conservation of changed lung image in reconvalescents was
estimated.

Differential diagnosis between infection mononucleosis and similar to
mononucleosis form CMVI was carried out. It was estimated that for form
similar to the mononucleosis one is the absence of tonsillitis and
monocytosis in blood. Limphadenopathy is expressed insignificantly. The
final diagnosis is possible to the exposed markers of CMV.

First it was determined the therapeutically effectiveness of laferon
in CMVI in children, its antivirus and immunomodulating activity.

Rational scheme of use of this preparation in combination with
pathogenetic therapy was proposed.

For early diagnostics of CMVI in children, the algorithm of examination
of patients was worked out.

Key words: cytomegalovirus infection, clinical manifestations,
diagnostics, treatment.

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