AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE ?INOEOOO OOEC?AO??? ? IOEUeIIIIEIA??
?i.O.A.ssIIANUeEIAI

Aa?a?iie Aiae??e ?aaiiae/

OAeE : 616-009-:615.45

*anoioa, ee?i?ei-?ioiieia?/i? iniaeeaino? oa i?iaiicoaaiiy

iaaeeeaiaioicii? aea?a?? o in?a, ui i?aeaeaeeny aianoac??

14.01.29 — ee?i?/ia ?ioiieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien

?aaioa aeeiiaia a A?iieoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i.I.?.Ie?iaiaa IIC Oe?a?ie

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe Caeeia Na?a?e A?eoi?iae/,
A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.?.Ie?iaiaa IIC
Oe?a?ie, eaoaae?a ooec?ao??? c eo?nii ee?i?/ ii? ?ioiieia?? oa
aea?aieia??, aeioeaio.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee Aoii?ia Aaeeia Ai?en?aia, Iaoe?iiaeueiee iaaee/iee
oi?aa?neoao ?i.I.I.Aiaiiieueoea, Iaoeiai-aeine?aeiee eaai?aoi?iee
oeaio?, eaai?aoi??y ee?i?/ii? ?ioiieia??, caa?aeoth/a; aeieoi? iaaee/ieo
iaoe, i?ioani? Iaeueieeia Ieaa Oaiaein?eiae/, Ee?anueeee
iaoeiai-aeine?aeiee ?inoeooo ioiea?eiaieia?? ?i.I.N.Eieii?e/aiei IIC
Oe?a?ie, eaai?aoi??y iaoio?c?ieia?? oa ?ioiieia??, caa?aeoaa/.

I?ia?aeia onoaiiaa: Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC
Oe?a?ie, eaoaae?a ee?i?/ii? ?ioiieia?? oa aea?aieia??.

Caoeno a?aeaoaeaoueny “29” aa?aniy 1999 ?. i13 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.552.01. i?e ?inoeooo? ooec?ao??? ?
ioeueiiiieia?? ?i.O.A.ssiianueeiai AII Oe?a?ie (252110,i.Ee?a, INI-680,
oca?c I?ioan?a y?,7).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeooo? ooec?ao???
? ioeueiiiieia?? ?i.O.A.ssiianueeiai AII Oe?a?ie (i.Ee?a,oca?c I?ioan?a
y?,7).

Aaoi?aoa?ao ?ic?neaiee “25” na?iiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee AE.A.Aaaioe?aa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. A inoaii? ?iee aea?a?/ii caoai?thaaiiy (AC)
oa?eoee aei /enea iaeaieueo ?iciianthaeaeaiieo [A.I.Iooeee oa ?i.,1998;
TH.E.Oauaiei e ae?.,1999]. Ca ioe?ieaie oao?aoe?a [A.I.Iaiueei,1997;
I.E.Eaneoea,1998] aiie iin?aeathoue o?ao? i?noea o no?oeoo??
caoai?thaaiue i?ney oai?ia na?oeaai-noaeeiii? nenoaie ? iieieia?/ii?
iaoieia??.

A no?oeoo?? AC [N.A. Oaaei?iae/,1991; A.I. Iooeee oa ?i.,1993; I.A.
Aiiaea?/oe,1995] iaaeeeaiaioicia aea?a?y (IA) neeaaea? a?ae 14.4 aei
33.0%. I?e/iio, ca aeaieie A.E. Nieieiaie [1990], A.N.Eiiaoeia [1992] a
oa?aiaaoe/i?e ee?i?oe? /anoioa IA noaiiaeoue 1 — 5%, a na?aae iia?/ii?
ae?? iaaeeeaiaioicieo i?aia?ao?a acaaae? aiia caeia? a?ey 66%
[A.E.Iuoeeee e ae?., 1991; A.N.Eiiaoei,1992].

A no/ani?e iaoeia?e e?oa?aoo?? [Aeae.O.Eaae,1990; H.Mitsuhata et
al.,1992; A.A.Oaaeinaaa e ae?.,1995] ana /ano?oa c’yaeythoueny aeai?
a?aeiinii aaaeeeaino? i?iaeaie IA na?aae oai?eo, yeei aoea i?iaaaeaia
aianoac?y. A?aeiii, ui ii iaeei ie?aii acyoee aianoaoee ia iiaea
aaeaeaaoii caaacia/eoe oni eiiiiiaioe aianoaci? — aiiiioe/iee nii,
iae?ii’yciao aeieaaeo i aiaeueaacith. Oea ciaia’yco? oao?aoe?a
canoiniaoaaoe i?ae /an iia?aoe?? a?ae 5 aei 14 iaaeeeaiaioicieo
i?aia?aoia c ??ciiieaiiaith aei?th. Aaaaeaiiy a i?aaiici oai?iai oaei?
e?eueeino? iaaeeeaiaioicieo niieoe, a oaeiae aaeeea eieueeinoue
iia?aoeaieo ao?o/aiue i?ae ia?eicii (iiiaae 2 iei.o ??e a Oe?a?i? oa 45
000 o A?iieoeueei? iaeano?) noai?ththoue i?iaeaio ?icaeoeo IA i?e
i?iaaaeaii? aianoac?? ua a?eueo aeooaeueiith [Aeae.O.Eaae,1990; J.L.
Theissen et al.,1995; E.A.Neeeia,1998].

A?eueo?noue oao?aoe?a aaaaeathoue, ui IA i?ae /an aianoac?? aeieea?
/ano?oa o aeaeyae? aiao?eaeoe/iiai oieo, a?iioi- aai ea?eiainiacio,
oe??ieo i?iya?a, ae?aaiinoeea yeeo aeineoue neeaaeia ? iio?aao?
i?iaaaeaiiy eiiieaeniiai aea?ai-?ioiieia?/iiai ianoaaeaiiy oai?eo
[A.N.Eiiaoei,1992; E.A.Iao?ia e ae?.,1992; N.A.Caeeia,1996]. Ne?ae
i?aee?aneeoe, ui oey i?iaeaia a aianoac?ieia?? ii?aeio?oueny c? cia/ieie
o?oaeiiuaie c o?aooaaiiyi oiai, ui i?ae /an ia?eico iaoe??io
ciaoiaeeoueny i?ae iaaeeeaiaioiciith naaeaoe??th oa i?i?aeaenaoe??th,
ye? cia/ii oneeaaeiththoue ioe?ieo ee?i?/iiai ia?aa?ao IA i?ae /an
iia?aoeaiiai ao?o/aiiy [Aeae.O.Eaae,1990; O.R.Hung,1994]. Iaiao?aeii
oaeiae aeiaeaoe, ui a e?oa?aoo?? iaeaea a?aenooi? no/ani? aeai? i?i
/anoioo, ao?ieia?/io no?oeoo?o, ee?i?ei-?ioiieia?/i? iniaeeaino?,
iiaeeea?noue i?iaiicoaaiiy ?icaeoeo IA i?ae /an ciaaiethaaiiy. A Oe?a?i?
oae? ?iaioe iaeaea a?aenooi?. Oaeei /eiii, c o?aooaaiiyi anueiai
aeuaiaaaaeaiiai ne?ae aaaaeaoe ieoaiiy IA a aianoaciieiai? aeooaeueiith
iaoeiaith oa i?aeoe/iith i?iaeaiith, yea iio?aao? iiaeaeueoiai aea/aiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa a
o?aaiaioii eiieo?nii? aea?aeathaeaeaoii? oaie eaoaae?e ooec?ao??? c
eo?nii ee?i?/ii? ?ioiieia?? oa aea?aieia?? A?iieoeueeiai aea?aeaaiiai
iaaee/iiai oieaa?neoaoo ?i.I.?.Ie?iaiaa ca caiiaeaiiyi IIC Oe?a?ie:
“Ai?aeai?ieia?/ia aeine?aeaeaiiy aea?a?/ieo caoai?thaaiue
iaaio?iiiaaiiiai oa aio?iiiaaiiiai aaiaco” [N aea?ae?a?no?aoe?? 01.9.10
026085].

Iaoa aeine?aeaeaiiy. Iie?ioeoe ae?aaiinoeeo oa i?iaiicoaaiiy
iaaeeeaiaioicii? aea?a?? o in?a, ui caciaee aianoac??.

Caaaeaiiy aeine?aeaeaiiy. 1) Aecia/eoe /anoioo i no?oeoo?o
iaaeeeaiaioicii? aea?a?? a aianoaciieiai/iie i?aeoeoei ca aeaieie
?ao?iniaeoeaiiai aiae?co iaoa??ae?a ?noi??e oai?ia iaoe??io?a, ui
caciaee aianoac??.2) Aea/eoe ee?i?ei-?ioiieia?/i? iniaeeaino? ia?aa?ao
iaaeeeaiaioicii? aea?a??, ui ?icaeioeany i?ae /an i?iaaaeaiiy ia?eico.3)
Aecia/eoe e?eoa??? i?iaiicoaaiiy ?eceeo aeieeiaiiy iaaeeeaiaioicii?
aea?a??o oai?eo, yeei ia?aaeaa/a?oueny i?iaaaeaiiy ciaaiethaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa ia cia/iiio eeii?/iiio
iaoa?iaei aea/aia /anoioa iaaeeeaiaioicii? aea?a?? o in?a, ui
i?aeaeaeeny ciaaiethaaiith i?ae ??ciiiai?oieie aeaeaie aianoac??.
Aecia/aia ao?ieia?/ia no?oeoo?a iaaeeeaiaioicii? aea?a?? oa
eeii?ei-iioiieiai/ii iniaeeainoi ?? ia?aa?ao o iaoe??io?a, ui caciaee
aianoac??. ?ic?iaeaii e?eoa??? i?iaiicoaaiiy ?eceeo ?icaeoeo
iaaeeeaiaioicii? aea?a?? o in?a i?ae /an i?iaaaeaiiy ia?eico.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Io?eiai? aeai? a?aeiinii
/anoioe, ao?ieia?/ii? no?oeoo?e, ee?i?ei — ?ioiieia?/ieo iniaeeainoae
iaaeeeaiaioicii? aea?a?? o oai?eo, ui caciaee iia?aoeaiiai ao?o/aiiy
i?ae aianoac??th, aeicaieythoue nooo?ai iie?ioeoe ye?noue ae?aaiinoeee
iaaeeeaiaioicii? aea?a?? ? aoaeoeai?noue e?eoaaiiy a?aeiia?aeii?
eaoaai??? in?a. ?ic?iaeaia eiii’thoa?eciaaia i?ia?aia i?iaiicoaaiiy
?eceeo aeieeiaiiy iaaeeeaiaioicii? aea?a?? o oeueiai eiioeiaaioo oai?eo,
yea iiaea aooe ?aaeueii ao?eaia o i?aeoeeo caeeaae?a ioi?iie caei?ia’y,
ui aoaea ni?eyoe i?aeaeuaiith aoaeoeaiino? i?io?eaeoeee ?icaeoeo
iaaeeeaiaioicii? aea?a?? o in?a, ui i?aeeyaathoue iia?aoeaiiio
ao?o/aiith i?e aeei?enoaii? ??cieo aeae?a aianoac?ieia?/iiai
caaacia/aiiy.

Iniaenoee aianie caeiaoaa/a. Iniaenoee aianie aaoi?a iieyaa? a
i?iaaaeaii? ee?i?/iiai ianoaaeaiiy oai?eo (100%), eaai?aoi?iiai
aea?aieia?/iiai ianoaaeaiiy iaoe??io?a (60%), eaai?aoi?iiai
?ioiieia?/iiai ianoaaeaiiy (25%), noaoenoe/i?e ia?iaoe? iaoa??ae?a
aeine?aeaeaiiy (100%), ?ic?iaoe? eiii’thoa?ii? i?ia?aie i?iaiicoaaiiy
?eceeo ?icaeoeo iaaeeeaiaioicii? aea?a?? o in?a, ui i?aeeyaathoue
iia?aoeaiiio ao?o/aiith i?ae aianoac??th (90%). An? iaoeia? ?acoeueoaoe
aeine?aeaeaiue, ye? aeiinyoueny ia caoeno, io?eiai? aaoi?ii naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee ? iniiai? iieiaeaiiy
?iaioe aeiiia?aeaeeny ia eiioa?aioe?yo iieiaeeo a/aieo A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo [A?iieoey, 1995,1996], caniaeaiiyo
iaeanieo iaoeiaeo anioe?aoe?e ooec?ao??a, ioeueiiiieia?a, iioiieiaia ?
aea?aieia?a oa aianoaciieiaia-?aai?iaoieia?a [A?iieoey,1998], I
iaoe?iiaeueiiio eiia?an? Oe?a?ie c ?ioiieia??, aea?aieia?? oa
?ioii?aaa?e?oaoe?? [Aeoooa, 1998], II c’?cae? ooec?ao??a ?
ioeueiiiieia?a Oe?a?ie [Ee?a,1998], iaoeia?e eiioa?aioe??, i?enay/ai?e
10-??//th ee?i?/ii? e?ea?i? N8 i.Ee?aa [Ee?a,1998].

Ioae?eaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? o 7 ioae?eaoe?yo: noaoae
o iaoeiaeo aeaeaiiyo — 4, oacao iaoa??ae?a c’?cae?a oa eiioa?aioe?e — 2,
ca??ieeao iaoeiaeo i?aoeue — 1.

Ai?iaaaeaeaiiy a i?aeoeeo. Iaoa??aee aeine?aeaeaiiy ai?iaaaeaeai? a
?iaioo ?ioiieia?/iiai oeaio?o A?iieoeueeiai iaeaniiai
i?ioeooaa?eoeueiciiai aeeniaina?o, aea?aieia?/iiai eaa?iaoo A?iieoeueei?
iaeanii? ee?i?/ii? e?ea?i? ?i.I.?.Ie?iaiaa, a?aeae?eaiue ?aai?iaoe?? oa
aianoac?ieia?? A?iieoeueei? iaeanii? ee?i?/ii? e?ea?i? ?i.I.?.Ie?iaiaa
oa A?iieoeueeiai ?aeiiiai oa?eoi??aeueiiai ee?i?/iiai iaaee/iiai
ia’?aeiaiiy. Iaoa??aee aeine?aeaeaiue oaeiae aeei?enoiaothoueny i?e
/eoaii? eaeoe?e e?ea?yi OOE oa nooaeaioai ia eaoaae?? ooec?ao??? c
eo?nii ee?i?/ii? ?ioiieia?? oa aea?aieia?? ? ia eaoaae?? caaaeueii?
o??o?a?? c eo?nii aianoac?ieia?? oa ?ioaineaii? oa?ai?? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.I.?.Ie?iaiaa.

Ianya oa no?oeoo?a aeena?oaoe??. ?iaioa aeeeaaeaia ia 135 noi??ieao
iaoeiiieno, ?ethno?iaaia 16 oaaeeoeyie, 15 ?enoieaie, Aeena?oaoe?y
neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, iaoa??ae?a oa iaoiae?a
aeine?aeaeaiiy, 3 ?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy,
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, aeac?aieea e?oa?aoo?e, yeee
aeeth/a? 227 ?ia?o, o oiio /ene? 78 a?o/eciyieo, 98 e?a?i NIAe, 51
?iicaiieo aaoi??a.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeey ae??oaiiy caaaeaiue ye?
iinoaaeai? a ?iaio? iaie iniaenoi aoei i?iaaaeaii a?aeiia?aeia
aeine?aeaeaiiy 426 in?a, ui ciaoiaeeeeny ia e?eoaaii? o o??o?a?/iiio
a?aeae?eaii? A?iieoeueei? iaeanii? ee?i?/ii? e?ea?i? ia i?ioyc? 1998 ?.
? caciaee iia?aoeaiiai ao?o/aiiy i?ae aiaeio?aoaaeueiei ia?eicii. E??i
iniaenoiai aeine?aeaeaiiy iaoe??io?a, ye? aoee i?iiia?iaai? i?ae
aiaeio?aoaaeueiei ia?eicii, iaie aoa i?iaaaeaiee ?ao?iniaeoeaiee aiae?c
iaoa??ae?a ?noi??e oai?ia 1637 iaoe??io?a, ui ciaoiaeeeeny ia e?eoaaii?
a o??o?a?/iiio a?aeae?eaii? A?iieoeueei? iaeanii? ee?i?/ii? e?ea?i? ia
i?ioyc? 1997-1998 ??..

Aea/aiiy ao?ieia?/ii? no?oeoo?e IA na?aae iaoe??io?a, ui i?aeaeaeeny
aianoac??, i?iaiaeeeiny iaie ca aeiiiiiaith o?aaeeoe?eieo a aea?aieia??
oa ?ioiieia?? iaoiae?a aeine?aeaeaiiy. Noaia ianoaaeaiiy oe??? eaoaai???
oai?eo aeeth/aea cae?aiiy aea?aieia?/iiai aiaiiaco ca?aeii oi?o?eiaai?e
aieao?-iieooaaeueieea [A.I.Iooeee,1992], aea/aiiy iniaeeainoae
ee?i?/iiai ia?aa?ao ia?eico a eiaeiiio ie?aiiio aeiaaeeo, oice/ia
ianoaaeaiiy oai?eo, eaai?aoi?i? aea?aieia?/i? oa ?ioiieia?/i?
aeine?aeaeaiiy. C iaoith aecia/aiiy aiia?/ooeeainoi i?aai?cio
ianoaaeaieo aei iaaeeeaiaioicieo i?aia?ao?a, ye? aoee canoiniaai? i?e
i?iaaaeaii? ia?eico (ao?ii?i, ae?iaae?ie, e?aeiea?i, o?iiaioae, eaoai?i,
ae?oee?i, a?aeoai, oaioai?e), iaie aoee canoiniaai? ?aaeoe?y
aeaa?aioeyoe?? iianenoeo ee?oei ca Oaee?, ?aaeoe?y iiaiaioei? iia?aoei?
eaeeioeeoia [A.O.Oaaeinii, 1982], aecia/aiiy iieacieea iioeiaeaeaiiy
iaeo?io?e?a [A.A.O?aaeeei,1985], iaoiae ?ioiioa?i?noiiao??? c
aiaeiiaiaeieie iaaeeeaiaioicieie i?aia?aoaie [N.A.Caeeia,1995]. Iaie ia
aeiaaeeiai c iaoith aecia/aiiy aiia?/ooeeainoi aei iaaeeeaiaioicieo
i?aia?aoia ia canoiniaoaaeenue oei?ii oanoe, ineieueee ca aeaieie
aieueoinoi oaoiaoeia-aea?aieia?a [A.E.Iuoeeee, 1991; A.I.Iooeee,1992;
A.E.Nieieiaa,1998] aiie iathoue aeineoue iaaenieo iioi?iaoeaiinoue, a
oaeiae iiaeooue aooe iaaacia/ieie aeey aiaeiiaiaeii? eaoaai?i?
ianoaaeaieo, caeaoi? aeeeeeaoe aeiaeaoeiao nainea?e?caoe?th aei e?e?a
oiui. C iaoith ?ioiieia?/iiai ianoaaeaiiy iaie aoa canoiniaaiee eiiieaen
oi?o?eiaaieo oano?a 1 oa 2 ??aiy ca iaoiaeeeaie, ui iaaaaeai?
E.O.*a?iooaiei oa ni?aaao.[1988,1990]. Aecia/aiiy ?ioiieia?/ieo
iaoai?ci?a ?icaeoeo IA o ianoaaeaieo iaie oai?eo i?iaiaeeeiny ?c
aeei?enoaiiyi eeaneo?eaoe?? Aeaeaeea-Eoiana [1975]. Io?eiai? ?acoeueoaoe
aeine?aeaeaiue aoee ia?iaeai? ca aeiiiiiaith iaoiae?a aa??aoe?eii?
noaoenoeee. Aeinoia??i?noue ?ica?aeiinoae aecia/aeany /a?ac e?eoa??e
Nouethaeaioa (t) ? ioe?ithaaeany ca aeiiiiiaith aeia??/i? a??ia?aeiino?
?. ?ica?aeiino? aaaaeaeeny aeinoia??ieie i?e ?<0.05. Aca?iica’ycie (ei?aeyoe?y) i?ae ii??aithaaieie aaee/eiaie a?aeia?aaeaeany o aeaeyae? eiao?oe??io?a ei?aeyoe?? (r) ca iaoiaeii A.O. Na?aiei, A.A. ??iaeiai? [1989]. An? ii??aiyiiy a ?iaio? i?iaiaeeeeny i?e oiia? ?ai?acaioaoeaiino? aeai?ie. C iaoith i?iaiicoaaiiy ?eceeo aeieeiaiiy iaaeeeaiaioicii? aea?a?? i?ae /an i?iaaaeaiiy aianoac?ieia?/iiai caaacia/aiiy iaie canoiniaaii iaoiae iine?aeiaii? ae?aaiinoe/ii? i?ioeaaeo?e [A.A.Aoaea?,1978]. ?ic?aooiee a ?iaio? i?iaiaeeeeny ?c canoinoaaiiyi ia?niiaeueiiai eiii’thoa?o IBM/AT 42Mb 386/EMS o ?aieao noaoenoe/iiai iaeaoo SuperCalc 5.0, a?ao?/ia a?aeia?aaeaiiy ?acoeueoao?a aeine?aeaeaiue aeeiioaaeinue o iaaeao iaeao?a FoxGraph, SuperCalc 5.0, ioi?ieaiiy oa ae?oe ?iaioe - o oaenoiaiio ?aaeaeoi?? Lexicon 8.92. ?acoeueoaoe aeine?aeaeaiue. I?e ?ao?iniaeoeaiiio aiae?c? 1637 ?noi??e oai?ia iaoe??io?a, ui i?aeaeaeeny iia?aoeaiiio ao?o/aiith i?ae aianoac??th, c’ynoaaeiny, ui na?aae caoai?thaaiue o ianoaaeaieo iaie in?a ia?aaaaeio aieueo?noue neeaee ae?aceiaa oai?iaa oeoieo ? 12-iaei? eeoee (17.04%), aeia/ieai’yia oai?iaa (15.03%), aino?ee aiaiaeeoeeo (14.78%) oa iaia?eoeie (10.26%). Ne?ae aeiaeaoe, ui o aeiaaeeao iayaiino? o oai?eo ae?aceiai?, aeia/ieai’yii? oai?iae iia?aoeaia ao?o/aiiy i?iaiaeeeiny c aeei?enoaiiyi aiaeio?aoaaeueiiai ia?eico, i?e iayaiinoi aino?iai aiaiaeeoeeoo - ic canoinoaaiiyi aioo?ioiueiaaiii? aianoaci?, a i?e iaia?eoei? - iinoeaaiai ciaaiethaaiiy. Noaoenoe/iee aiae?c aeuaiaaaaeaii? eaoaai??? in?a ca a?eii oa noaooth iieacaa, ui nooo?aeo ?ica?aeiinoae i?ae neeaaeii ianoaaeaieo iaie in?a, yeei aoee canoiniaai? ??ci? aeaee aianoac?? ia aoei (?>0.05 aeey an?o aeiaaee?a).
Na?aae oeeo eaoaai??e in?a i?noeaaa ciaaiethaaiiy aoei cae?eniaii o 312
in?a (19.06%), aioo??oiueiaaiia aianoac?y — o 308 in?a (18.81%),
nieiiiiiceiaa aianoac?y o 157 in?a (9.59%), aiaeio?aoaaeueiee ia?eic — o
860 in?a (52.54%).

I?e aea/aii? iaoa??ae?a i?iaaaeaiiy aianoac?ieia?/iiai caaacia/aiiy ie
a?ae?a?aee aeiaaeee oneeaaeiaiue, ye? iaee i?noea i?ae /an i?iaaaeaiiy
ia?eico. Oaeei /eiii, aiae?c aeaieo ?ao?iniaeoeaiiai aeine?aeaeaiiy,
iieacaa, ui caaaeueia /anoioa oneeaaeiaiue o ianoaaeaieo oai?eo i?ae /an
i?iaaaeaiiy aianoac??, neeaea 10.45% (171 c 1637) iaoe??io?a, ye?
iia?oaaeeny i?ae aoaeue-yeith aianoac??th, aea iaeaea an? oe? aeiaaeee
(169 c 860) noinoaaeeny iaoe??io?a, o yeeo iia?aoeaia ao?o/aiiy
i?iaiaeeeiny i?e aeei?enoaii? aiaeio?aoaaeueiiai ia?eico (19.65%
niinoa?aaeaiue), oiio a iiaeaeueoiio ie i?iaiae?coaaee naia aeiaaeee
oneeaaeiaiue i?e i?iaaaeaii? oeueiai aeaeo aianoac?ieia?/iiai
caaacia/aiiy. I?e aea/aii? iaoa??ae?a ?noi??e oai?ia aeuacacia/aieo
iaoe??io?a ie aeiaeaoeiai i?iaaee a?aea?? oeo aeiaaee?a, a yeeo i?ae /an
i?iaaaeaiiy aianoac?? o oai?eo aeieeaee o? /e ?io? oneeaaeiaiiy, ye?
iiaeii aoei ca’ycaoe c aaeeaaiiyi a?aeiia?aeieo iaaeeeaiaioicieo
cania?a. I?e oeueiio a?aoiaoaaeeny oae? neiioiie ?icaeoeo aea?a?/ieo
?aaeoe?e i?ae /an i?iaaaeaiiy ia?eico [Aeae.O.Eaae,1990; J.Birnbaum,
1994; M.C.Laxenaire, 1996] ye ?aioiaa ii/a?aii?iiy oe??e, iaa?ye iaee//y
oa/aai iiyaa ia o?e? ?ioaineaii caaa?aeaiiai o?o?ea?iiai aeneio, ??cea
cieaeaiiy a?oa??aeueiiai oeneo c ii?ooaiiyi aaiiaeeiai?ee, a?iioi- aai
ea?eiainiaci. Oaeiae c iaoith ?iciaaeoaaiiy oiene/ieo oa aea?a?/ieo
?aaeoe?e ia iaaeeeaiaioici? i?aia?aoe iaie canoiniaai? caaaeueiii?eeiyo?
a aea?aieia?? e?eoa??? [A.I.Iooeee,1989; A.E.Iuoeeee,1991;
N.A.Oaaei?iae/,1994]. Aiae?c ?ao?iniaeoeaieo aeaieo iieacaa, ui eeoa 84
c 169 aeiaaee?a oneeaaeiaiue (49.70% niinoa?aaeaiue) i?ae /an ia?eico
iiaeia aoei a?aeianoe c aeinoaoi?i nooiaiai aeinoia??iino? aei ee?i?/ieo
oi?i IA. Na?aae ieo ia?aaaaeio a?eueo?noue niinoa?aaeaiue (92.86%) ie
a?aeianee aei aiao?eaeoe/iiai oieo, ?io? oi?ie IA (oe??i?, ?ani??aoi?i?)
a?aei?/aeeny cia/ii ??aeoa (1.19% oa 5.95% a?aeiia?aeii, ?<0.01 aeey iaio aeiaaee?a). Na?aae oneeaaeiaiue i?ae /an aiaeio?aoaaeueiiai ia?eico, ui ia aoee a?aeianai? iaie aei IA (50.30% niinoa?aaeaiue), oaeiae ia?aaaaeaa (89.41% aeiaaee?a) oie (a?iiaieai?/iee o 73.48%, aaii?aa?/iee o 26.52% niinoa?aaeaiue), ?io? aeaee oneeaaeiaiue (a?ia?oaic?y, a?eoi?y) i?e i?iaaaeaii? aianoac?? a?aei?/aeeny cia/ii ??aeoa (7.06% oa 3.53% a?aeiia?aeii, ?<0.01). Oaeei /eiii, i?e aeaoaeueiiio aiae?c? aeaieo aea?aieia?/iiai aiaiiaco, ee?i?/iiai ia?aa?ao ia?eico, ee?i?/iiai oa eaai?aoi?iiai ianoaaeaiiy oai?eo o i?neyiia?aoe?eiiio ia??iae? eeoa o 84 c 860 /ieia?e ( 9.77%) i?iyae oneeaaeiaiue i?ae /an i?iaaaeaiiy aiaeio?aoaaeueiiai ia?eico iiaeii aoei c aeinoaoi?i nooiaiai iaae?eiino? o?aeooaaoe ye neiioiie IA. Ne?ae aeiaeaoe, ui i?e i?iaaaeaii? nieiiiiiceiai? aianoac?? eeoa 1 aeiaaeie c 157 (0.64%) iaie aoa a?aeianaiee aei ee?i?/ieo oi?i IA. Ioaea, ?ao?iniaeoeaiee aiae?c iaoa??ae?a 1637 ?noi??e oai?ia iieacaa, ui a 84 c 1637 ianoaaeaieo (5.13%) i?e i?iaaaeaii? aianoac?ieia?/iiai ao?o/aiiy aeieeee neiioiie IA, i?e/iio ia?aaaaeii (o 78 c 84 in?a, ui neeaei 92.86% aeiaaee?a) o aeaeyae? aiao?eaeoe/iiai oieo. Aea ne?ae i?aee?aneeoe, ui oe? 84 aeiaaeee ?icaeoeo IA i?eiaaeaee ia i?iaaaeaiiy iia?aoeaiiai ao?o/aiiy i?ae aiaeio?aoaaeueiei ia?eicii, oiaoi /anoioa ?icaeoeo IA i?e oeueiio aeae? ciaaiethaaiiy neeaaea? 9.77% (o 84 c 860 in?a), ui cia/ii ia?aaeuo? (?<0.01) ?iciianthaeaeaii?noue IA [A.I.Iooeee oa ?i.,1993; I.A.Aiiaea?/oe, 1995] na?aae ianaeaiiy A?iieoeueei? iaeano? (2.24%) ? ?iaeoue oeth i?iaeaio aeoaea aaaeeeaith aeey a?aeiia?aeieo eaoaai??e oao?aoe?a. Aaaeeeaa cia/aiiy o aeieeiaii? IA i?ae /an i?iaaaeaiiy ia?eico iiaeii? iaoe noaoue oa a?e ianoaaeaieo, aeae aianoac?ieia?/iiai ao?o/aiiy, iayai?noue o?ii?/ieo caoai?thaaiue oeoieiai-eeoeiaiai o?aeoo, ia/?iee, na?oeaai-noaeeiii? nenoaie, i?aai?a aeeoaiiy, aea?a?/ieo caoai?thaaiue (o oiio /ene? ? IA), iaoyaeaia niaaeeia?noue ii AC, o?eaaea aaeeaaiiy e?e?a, iiaoi?i? iia?aoeai? ao?o/aiiy oiui [Aeae.O.Eaae,1991;M.C.Laxenaire,1997]. Oiio iaie c iaoith aecia/aiiy oaeoi??a, ui iiaee ni?eyoe ?icaeoeo IA i?ae /an i?iaaaeaiiy ia?eico, oaeiae aoee i?iaiae?ciaai? a?aeiia?aei? aeai? c ?noi??e oai?ia 860 iaoe??io?a, ye? i?aeaeaeeny o??o?a?/iiio ao?o/aiith i?ae aiaeio?aoaaeueiei ia?eicii. sse na?ae/eoue i?iaaaeaiee iaie aiae?c, o an?o a?eiaeo ae?aiaciiao IA aeaui /ano?oa aeieeaea o ae?iie (a?ae 21 aei 45 ?ie?a - 10.71%, a?ae 46 aei 60 ?ie?a - 17.86% oa 61 ??e ? a?eueoa - 25.0%,?>0.05), i?ae o
/ieia?e?a (8.33%,14.28% oa 23.81% aiaeiiaiaeii). Oaeei /eiii, na?aae
iaoe??io?a c IA ia?aaaaeaee ae?iee oa /ieia?ee ca a?eii a?ae 46 aei 60
?ie?a oa a?eueoa iaae iniaaie a?eueo iieiaeiai (21-45 ?ie?a) a?eo
(?<0.05). C iaoith aea/aiiy aieeao o?eaaeiai aaeeaaiiy e?e?a ia ?icaeoie IA ie i?iaiae?coaaee eiai /anoioo o ianoaaeaieo c IA oa o in?a aac ?? iciae. A?aeiia?aei? aeai? iieacaee, ui na?aae in?a c iciaeaie IA 41.07% iaoe??io?a aaeeaaee o?eaaeee /an e?ee, ia a?aei?io a?ae in?a aac i?iya?a IA, na?aae yeeo o?eaaeee /an aaeeaaee e?ee eeoa 27.84% ianoaaeaieo (?<0.01). Oai?? c iciaeaie IA a 46.43% aeiaaee?a iaee aeia/ieai’yio oai?iao (?<0.01), noiooi? caoai?thaaiiy i?aai?a aeeoaiiy - 21.43% (?<0.05), ui i?aeoaa?aeaeo? aeniiaee I.Ae.Aaeeaieoaaa [1984], A.I.Iooeeea [1992] i?i iayai?noue ni?eyoeeaeo oiia aeey aeieeiaiiy IA ia oe? ?ioaeoe?eiiai i?ioeano, yeee o ianoaaeaieo iaie oai?eo eieae?coaaany a aeia/iaea?aeieo i?ioieao oa i?aaiao aeeoaiiy. Oai?? c iciaeaie IA i?ae /an i?iaaaeaiiy ia?eico oaeiae iaee a?eueo /ano? aeac?aee a aiaiiac? ia i?iaaaeaiiy iiia?aaei?o iia?aoeaieo ao?o/aiue (22.67% aeiaaee?a), i?ae iniae aac iciae IA (8.37% niinoa?aaeaiue, ?<0.05). Oaeei /eiii, ia ?icaeoie IA i?ae /an i?iaaaeaiiy ia?eico nooo?aee aieea iaee iayai?noue o ianoaaeaieo aeia/ieai’yii? oai?iae, o?ii?/ieo ianiaoeeo?/ieo caoai?thaaiue i?aai?a aeeoaiiy oa iiia?aaei?o iia?aoe?e a aiaiiac?. A?aeiii, ui ia ?icaeoie IA o iaoe??io?a noaoe?iia??a oa?aiaaoe/iiai i?io?eth nooo?aee aieea iathoue ?io? aea?a?/i? caoai?thaaiiy [N.A.Oaaei?iae/,1991;C.Zent,1994; E.A.Eonn,1997]. A?aeiia?aeii ?o iayai?noue a?aei?/aia iaie o 25.0% in?a c IA ? eeoa o 2.45% ianoaaeaieo aac iciae IA (?<0.05), ui aeiaeaoeiai na?ae/eoue i?i aieea aoii?? ia iiaeoeoeith IA. Ia?ae?e noiooi?o AC o iaoeo ianoaaeaieo aeeth/aa a?iio?aeueio anoio, aea?a?/iee ?ei?o, aea?iaoeo ? iaaeeeaiaioicio aea?a?th, yea iaea i?noea ua aei i?iaaaeaiiy aianoac?? ? ia aoea iia’ycaia ?c canoinoaaiiyi cania?a aeey ia?eico. I?e/iio ne?ae aeiaeaoe, ui o in?a c iaoyaeeeaei aea?aieia?/iei aiaiiacii nooo?ai /ano?oa (14.28%) ?icaeaaany aiao?eaeoe/iee oie, i?ae o in?a (0.39%) c iaiaoyaeeeaei aea?aieia?/iei aiaiiacii (?<0.01). E??i oiai, o oai?eo ?c noiooi?ie AC o 66.67% aeiaaee?a niinoa??aaeanue iaoyaeeeaa niaaeeia?noue ii oeei caoai?thaaiiyi. Oae, aaoueee oeeo oai?eo iaee iciaee iie?iico, aoii?/iiai aea?iaoeoo, aea?a?/iiai ?ei?oo, a?iio?aeueii? anoie. Io?eiai? iaie aeai? a?aeiinii aieeao ia eiia??i?noue ?icaeoeo IA iayaiino? iaoyaeeeai? niaaeeiaino? ii AC oa noiooiio AC a oe?eiio a?aeiia?aeathoue aeaiei ?ioeo oao?aoe?a [E.Eaaa?,1990; A.A.Aaei, I.A.Iie?iiiniaa, 1997]. I?e ?ao?iniaeoeaiiio aiae?c? ?noi??e oai?ia iaoe??io?a c’ynoaaeiny, ui ao?ieia?/ieie /eiieeaie ?icaeoeo IA ca aeaieie aea?aieia?/iiai aiaiiaco o 28.57% aeiaaeeao aoee eiia?iaoe?? aeae?eueeio iaaeeeaiaioicieo cania?a (iai?oeee?i, a?naioie, aoacie, eiio??eae, ieaoeo?e?i, iaiaaa??i, iiaiea?i, a?oai?ie a?oie A, na/ia?ii? caniae, iiiiiii, i?iiaaeie, eaa?ioii, eiae, i?noeaa? aianoaoeee oiui). Ioaea, ca aeaieie ?ao?iniaeoeaiiai aiae?co iaoa??ae?a ?noi??e oai?ia iiaeia eeoa c oei /e ?ioei nooiaiai a??ia?aeiino? noaa?aeaeoaaoe, ui aeaui /ano?oa IA aeeeeeaee aioea?ioeee, i?aia?aoe eiaeo, i?noeaa? aianoaoeee, oi/a ne?ae aeiaeaoe, ui io?eiai? iaie aeai? ana ae oaee a oe?eiio ni?aiaaeathoue c ?acoeueoaoaie aeayeeo aaoi??a [Aeae.O.Eaae, 1990; E.A.Eonn,1997]. ?io? oao?aoe? [J.Birnbaum,1994; M.C.Laxenaire,1996] aaaaeathoue, ui iaea?eueo /anoi o oai?eo, ui i?aeaeathoueny iia?aoeaiei ao?o/aiiyi, ?a?no?o?oueny a?ia?/ooeea?noue aei i?i?aeaenaio?a, a?iiioee?a, ii?i?ae?a, eaoaeno. Oiio ne?ae aaaaeaoe, ui iaea?aeai? iaie oeyoii ?ao?iniaeoeaiiai aiae?co aeai? iiaeooue iaoe eeoa i???ioiaiee oa?aeoa? ? ia caeaoi? aeinoia??ii a?aeia?aceoe no?oeoo?o a?ia?/ooeeaino? aei iaaeeeaiaio?a-aianoaoee?a o ianoaaeaieo oai?eo. Oiio iaie a iiaeaeueoiio aoei i?iaaaeaii eiiieaenia ianoaaeaiiy 426 in?a, ui ciaoiaeeeenue ia e?eoaaii? o a?aeae?eaii? caaaeueii? o??o?a?? A?iieoeueei? iaeanii? e?ea?i?. An?i ianoaaeaiei aoei i?iaaaeaii iia?aoeaia ao?o/aiiy ?c canoinoaaiiyi aiaeio?aoaaeueiiai ia?eico c i?eaiaeo caoai?thaaiue i?aai?a /a?aaii? ii?iaeieie. Na?aae caoai?thaaiue o ianoaaeaieo iniaenoi iaie in?a ia?aaaaeaee ae?aceiaa, aeia/ieai’yia oai?iae, aino?ee aiaiaeeoeeo oa i?neyiia?aoe?ei? aaio?aeuei? eeee, ui a oe?eiio ni?aiaaeaei ?c no?oeoo?ith caoai?thaaiue o iaoe??io?a i?e ?ao?iniaeoeaiiio aiae?c? iaoa??ae?a ?noi??e oai?ia. Noaoenoe/iee aiae?c iniaenoi ianoaaeaieo iaie iaoe??io?a a caeaaeiino? a?ae ?o a?eo oa noao? iieacaa, ui na?aae ieo eeoa aeaui ia?aaaaeaee ae?iee (?>0.05) iaae
/ieia?eaie. O a?eia?e no?oeoo?? oai?eo oe??? a?oie iniae a?eii 21-45,
46-60, 61 ??e ? a?eueoa cono??/aeeny nooo?ai (?<0.01 aeey an?o aeiaaee?a) /ano?oa, i?ae oai?? o a?oe? aei 20 ?ie?a, ui oe?eeii i?e?iaeiuei c o?aooaaiiyi a?eueo iecueei? /anoioe iia?aoeaieo ao?o/aiue na?aae inoaii?o. I?iaaaeaia ii??aiyiiy ?acoeueoao?a aea/aiiy ee?i?/ieo iniaeeainoae ia?aa?ao IA oa oaeoi??a, ui i?aeaeuothoue ?ecee ?? ?icaeoeo, o oai?eo, ye? i?aeaeaeeny iia?aoeaiiio ao?o/aiith i?ae aiaeio?aoaaeueiei ia?eicii, ca aeaieie ?ao?iniaeoeaaieo oa iniaenoeo niinoa?aaeaiue. Ca ?ao?iniaeoeaieie aeaieie a 5.13% aeiaaee?a i?e i?iaaaeaii? aoaeue-yeiai iaoiaeo aianoac?ieia?/iiai caaacia/aiiy aeieeee neiioiie IA. Ne?ae i?aee?aneeoe, ui 98.92% an?o aeiaaee?a IA i?eiaaea? ia i?iaaaeaiiy iia?aoeaiiai ao?o/aiiy i?ae aiaeio?aoaaeueiei ia?eicii,oiaoi /anoioa ?icaeoeo IA i?e oeueiio aeae? ciaaiethaaiiy neeaaea? 9.77%. Ca aeaieie iniaenoeo niinoa?aaeaiue /anoioa IA i?ae /an i?iaaaeaiiy aiaeio?aoaaeueiiai ia?eico noaiiaeea 8.92% aeiaaee?a. A no?oeoo?? IA o in?a, ui aoee ianoaaeai? ?ao?iniaeoeaii, cia/io ia?aaaao iaa aiao?eaeoe/iee oie (92.86%), ea?eiai-oa a?iioiniaci a?aei?/aii o 5.95% ianoaaeaieo, a oe??i? i?iyae IA o aeaeyae? e?iiea’yiee oa iaa?yeo Ea?iea- o 1.19% in?a. Aeaui ?ioith aoea no?oeoo?a ee?i?/ieo i?iya?a IA i?e iniaenoiio ianoaaeaii? oai?eo. Oae, aiao?eaeoe/iee oie aeyaeaiee o 57.89% oai?eo, ea?eiai-oa a?iioiniaci - o 26.32% iaoe??io?a, oe??i? i?iyae IA - o 15.79% ianoaaeaieo. Oae? ?ica?aeiino? iiaee aooe iia’ycaieie c a?eueo iiaeeaeaiei ianoaaeaiiyi oai?eo i?e iniaenoiio ?o niinoa?aaeaii?, aeayeith ??cieoeath i?ae eiioeiaaioaie iaoe??io?a, ??cieie iaaeeeaiaioicieie i?aia?aoaie aeey oaiaeiiai ia?eico oiui. I?ioa, oaeoi?e, ui ni?eyee i?aeaeuaiith ?eceeo ?icaeoeo IA i?e ?ao?iniaeoeaiiio oa iniaenoiio niinoa?aaeaiiyo oai?eo aoee iaeaea iaeiaeiaeie (ae?ii/a noaoue, o?eaaea aaeeaaiiy e?e?a, iaoyaeaiee aea?aieia?/iee aiaiiac, iayai?noue noiooi?o caoai?thaaiue i?aai?a aeeoaiiy, aeia/ieai’yii? oai?iae, AC, iaoyaeaia niaaeeia?noue ii AC, iiaoi?i? iia?aoeai? ao?o/aiiy oiui). Ne?ae oaeiae i?aee?aneeoe, ui no?oeoo?a ee?i?/ieo i?iya?a IA o ianoaaeaieo iaie oai?eo a oe?eiio i?aeoaa?aeaeo?oueny ia/eneaiieie e?oa?aoo?ieie aeaieie [Aeae.O. Eaae,1990;M.M.Fisher,B.A.Baldo,1993], aea a?ae??ciy?oueny a?ae a?eueo ??ciiiai?oii? ee?i?/ii? no?oeoo?e IA o oai?eo ia ooaa?eoeueic [A.I.Iooeee,1992], o?ii?/iee a?iio?o [A.A.?onaiiaa, 1996], iiioeyoe?? ianaeaiiy iaeano? [I.A.Aiiaea?/oe,1995]. Aacoiiaii aaaeeeaei ? oe?eaaei a iao?e ?iaio? aoei aea/aiiy aaciina?aaei?o /eiiee?a IA, oiaoi iaaeeeaiaioicieo aea?aai?a. Iaie c oe??th iaoith aoee canoiniaai? cae?aiiy aea?aieia?/iiai aiaiiaco, c’ynoaaiiy iniaeeainoae ee?i?/iiai ia?aa?ao ia?eico, eaai?aoi?ieo aea?aieia?/ieo oano?a in vitro c iaaeeeaiaioicieie i?aia?aoaie (?aaeoe?? aeaa?aioeyoe?? iianenoeo ee?oei ca Oaee?, iieacieea iioeiaeaeaiiy iaeo?io?e?a, ?aaeoe?? ?ia?a?oe?? i?a?aoe?? eaeeioeeo?a, iaoiaeo ?ioiioa?i?noiiao???) a oaeiae oi?o?eiaaieo ?ioiieia?/ieo oano?a 1 oa 2 ??aiy, ui aeeiioaaeeny i?ney iia?aoeaiiai ao?o/aiiy c aeei?enoaiiyi aiaeio?aoaaeueiiai ia?eico. Aeacai? aeine?aeaeaiiy aoee i?iaaaeai? na?aae in?a aeine?aeii? (38 iaoe??io?a) oa eiio?ieueii? (32 iaoe??ioa) a?oi. A?aeiia?aeii aeaiei iaoiai aeine?aeaeaiiy, iaea?eueo /anoith i?e/eiith ?icaeoeo IA o oai?eo, ye? caciaee aianoac??, aoee oae? i?aia?aoe, ye ae?iaae?ie (63.16%), iiaiea?i (60.53%). Aeaui ??aeoa ?icaeoie IA o ianoaaeaieo aeeeeeaee n?aacii (36.84%), o?iiaioae (34.21%), e?aeiea?i (34.21%), ao?ii?i (31.58%), eae?inie (26.32%) oa oaioai?e (23.68%). Ua ??aeoa o ianoaaeaieo c IA aeyaeaia aeia?/ooeea?noue aei ae?oee?io (18.42%), eaoai?io (15.79%) oa a?aeoaio (10.53%). I?e/iio ia??aeei (49.0%) noai a?ia?/ooeeaino? iaoiiaethaaany iaeii/anii 2-3 iaaeeeaiaioicieie i?aia?aoaie, ui iaei aieea ia oi?ioaaiiy o iaoeo oai?eo iaea?eueo aaaeeeo ee?i?/ieo oi?i IA. Ne?ae a?aei?oeoe, ui iaea?aeaia iaie ao?ieia?/ia no?oeoo?a IA o oai?eo, ui i?aeaeaeeny iia?aoeaiiio ao?o/aiith i?ae aiaeio?aoaaeueiei ia?eicii, a?ae??ciy?oueny a?ae aeaieo ?iicaiii? e?oa?aoo?e [E.S.Assem,1990; J.Watkins, 1994]. Ca?aeii iieo/aieo iaie aeaieo, na?aae aioeaaiieo /eiiee?a IA i?ae /an i?iaaaeaiiy ia?eico ia?aaaaeathoue iaaeeeaiaioici? caniae aeey i?aiaaeeeaoe?? (ae?iaae?ie,ao?ii?i), caaaeuei? aianoaoeee (o?iiaioae, eae?inie), aoa?aeoeee (n?aacii), aioeno?ani?i? caniae (e?aeiea?i, iiaiea?i). Ia a?aei?io a?ae oeueiai aeinooii? ?iicaii? aeaea?aea [H.Mitsuhata et al.,1992; M.C.Laxenaire, 1996] na?ae/aoue, ui ia ia?oiio ieai? na?aae /eiiee?a IA i?ae /an i?iaaaeaiiy ia?eico ? i?i?aeaenaioe, eaoaen oa ieaciicai?ithaa/?. Oey ?ica?aei?noue a iaaaaeaieo aeaieo, ia iaoo aeoieo, iaoiiaeaia, c iaeiiai aieo, aeaui a?eueoei ia?ae?eii iaaeeeaiaioicieo i?aia?ao?a, ui canoiniaaii iaie i?e i?iaaaeaii? eaai?aoi?ii? aea?aieia?/ii? ae?aaiinoeee, c ?ioiai - oa?iaeieia?/ieie (a?aenooi?noue a e?ea?iyo no/anieo a?iiioee?a, iai?eeeaae i?iiioieo, oa i?i?aeaenaio?a) oa iaoiaeieia?/ieie iniaeeainoyie i?iaaaeaiiy caaaeueiiai ciaaiethaaiiy (a?aenooi?noue aia?aoo?e aeey iii?oi?eiao aeeoo?aiaaaeeeaeo ooieoe?e i?aai?cio iaoe??ioa i?ae /an i?iaaaeaiiy aianoac??) a Oe?a?i? oa ?ioeo e?a?iao na?oo. Iaie oaeiae aoea i?iaiae?ciaaia ?ioi?iaoeai?noue canoiniaaieo aeey ?aeaioeo?eaoe?? iaaeeeaiaioicieo aea?aai?a oano?a in vitro. Iaea?eueo ?ioi?iaoeaieie a ae?aaiinoeoe? IA o in?a, ui i?aeaeaeeny aianoac??, aeyaeeeny: eiiieaen iaoiae?a aea?aieia?/ieo aeine?aeaeaiue oa iaoiae ?ioiioa?i?noiiao??? (86.84% oa 78,95%, a?aeiia?aeii), iaioo ae?aaiinoe/io oe?ii?noue iaee ?aaeoe?y ?ia?a?oe?? i?a?aoe?? eaeeioeeo?a, iieaciee iioeiaeaeaiiy iaeo?io?e?a oa ?aaeoe?y aeaa?aioeyoe?? iianenoeo ee?oei ca Oaee?, ui a oe?eiio ni?aiaaea? c e?oa?aoo?ieie aeaieie [A.O. Aioooaei,1989; A.A. Oaaeinaaa e ae?., 1995; N.A. Caeeia, 1998], oi/a aiie ? noinothoueny ?ioeo eaoaai??e oai?eo ia IA. I?iaaaeaiee ei?aeyoe?eiee aiae?c i?ae aeaieie iaoiaeo ?ioiioa?i?noiiao??? oa ?acoeueoaoaie ?aaeoe?? aeaa?aioeyoe?? iianenoeo ee?oei ca Oaee?, ?aaeoe?? ?ia?a?oe?? i?a?aoe?? eaeeioeeo?a, iieacieeii iioeiaeaeaiiy iaeo?io?e?a i?iaeaiiino?oaaa iayai?noue na?aaeiueiai nooiaiy iaeiini?yiiaaii? ei?aeyoe?eii? caeaaeiino? i?ae ieie (r=+0.42±0.13; r=+0.53±0.11; r=+0.43±0.14 a?aeiia?aeii, ?<0.05 aeey an?o aeiaaee?a), ui ua ?ac i?aee?aneth? aenieo ae?aaiinoe/io oe?ii?noue iaoiaeo ?ioiioa?i?noiiao??? a ae?aaiinoeoe? IA. Ieoaiiy i?i ci?ie a ?ioiiiio noaoon? oai?eo ia IA aea/aii iaaeinoaoiuei [E.I.Ei?i/eei e ae?.,1985;A.A.Iieinooeia e ae?.,1986], a a oeo aeinooiieo e?oa?aoo?ieo aeaea?aeao, ui i?iaiae?ciaai? iaie, iaaiaeyoueny aeineoue ??ci? ?acoeueoaoe. I?iaaaeaiee iaie aiae?c aeaieo ?ioiieia?/iiai eaai?aoi?iiai ianoaaeaiiy iieacaa, ui a i?neyiia?aoe?eiiio ia??iae? a?eueo?noue na?aaei?o iieaciee?a ?ioiia?aie o ianoaaeaieo nooo?ai a?ae??ciyeeny a?ae ii?iaoeaieo. Oae, o i?iiia?iaaieo in?a c IA oa aac ?? iciae ieae/eie ca ii?io aeyaeeeny iieacieee aaniethoii? oa a?aeiinii? e?eueeino? e?ioioeeo?a, oaaioeeoa?ii? aeoeaiino? eaeeioeeo?a, aaeoa??oeeaeii? aeoeaiino? ne?iaaoee, oeo?o eiiieaiaioo, ?ioiiaeiaoe?i?a A, I, aaniethoii? oa a?aeiinii? e?eueeino? O-e?ioioeeo?a (A-?OE), ?o oaio?e?i-?acenoaioii? ? iniaeeai oaio?e?i-/ooeeai? noaiiioeyoe?e, ?aaeoe?? aeanoii? o?ainoi?iaoe?? e?ioioeeo?a c o?oiaaiaaethoei?iii, oeo?o aaoa?io?eueieo aaethoei?i?a, ui na?ae/eei ia ei?enoue ?icaeoeo aino?i? eiia?iiaaii? (i?e iineiae?iiiiio aiae?c? aeaieo ?ioiia?aie) ?ioiii? iaaeinoaoiino? o ianoaaeaieo. Na?aaei? iieacieee ?ioiia?aie in?a c IA oa aac ia? nooo?ai a?ae??ciyeeny i?ae niaith eeoa ca ??aiai IgE oa iieacieea AAN-?OE, ye? o ianoaaeaieo c IA aoee cia/ii aeueie (245.20±20.40 II oa 153.40±18.60 II, (0.24±.0.03)* 109 /e oa (0.13±0.02)*109 /e,a?aeiia?aeii),a oaeiae ca ??aiai aaniethoii? oa a?aeiinii? e?eueeino? oaio?e?i-/ooeeai? noaiiioeyoe?? A-?OE ((0.08±0.01)*109/e oa (0.17±0.02*109/e, (6.10±1.07)% oa (11.80±1.16)%, a?aeiia?aeii), ye? aoee nooo?ai ieae/eie o in?a c IA, ui i?ecaaei aei i?aeaeuaiiy ?ioii?aaoeyoi?iiai ?iaeaeno o ianoaaeaieo c iciaeaie IA (4.16 ± 0.36) o ii??aiyii? c oai?eie aac ieo (2.01 ± 0.28 i?e ?<0.01). I?e iineiae?iiiiio aiae?c? ?ioiia?aie aeuacacia/ai? iieacieee aeacoaaee ia iayai?noue o in?a c IA iciae aea?a??, ui ni?aiaaea? c aeaieie e?oa?aoo?e [I.Ae.Aaneethe,1993; D.Vervloet,1998] a?aeiinii a?eueo /anoiai oi?ioaaiiy o oai?eo ia AC naia oaeeo iciae ii?ooaiue ?ioi?oaoo. Ie i?iaaee aecia/aiiy ?ioiieia?/ieo iaoai?ci?a ?icaeoeo IA o ianoaaeaieo iaie oai?eo c aeei?enoaiiyi eeaneo?eaoe?? aea?a?/ieo ?aaeoe?e Gell and Coombs [1975] c aeiiiaiaiiyie Roit [1991]. Iaaeeeaiaioici? aea?a?/i? ?aaeoe?? 1 oeio, ui aoee iia’ycai? c IgE ie niinoa??aaee o an?o 38 iaoe??io?a c IA, ui aeieeea i?ae /an i?iaaaeaiiy ia?eico. Aei ?aaeoe?e 1 oeio, ie a?aeianee iaaeeeaiaioiciee aiao?eaeoe/iee oie, a?iioi-oa ea?eiainiaci, e?iiea’yieo oa aia?iiaa?ioe/iee iaa?ye Ea?iea. Iaaeeeaiaioici? aea?a?/i? ?aaeoe?? ?ioeo oei?a ie o ianoaaeaieo ia niinoa??aaee, ui ci?aiaaea? c aeaieie ?ioeo oao?aoe?a [Aeae.O.Eaae,1990; M.C.Laxenaire,1996] a?aeiinii ?icaeoeo naia ?aaeoe?e aiao?eaeoe/iiai oeio i?e i?iaaaeaii? o oai?eo iia?aoeaiiai ao?o/aiiy i?ae aianoac??th. C o?aooaaiiyi io?eiaieo iaie aeaieo iiaeia aaaaeaoe, ui iniiaieie ee?i?/ieie iniaeeainoyie IA o in?a, ui i?aeaeaeeny aianoac?ieia?/iiio caaacia/aiith, ? ?? a?eueo /anoee ?icaeoie o ae?iie (a?eii a?ae 21 aei 45 ? a?ae 46 aei 60 ?ie?a) o aeaeyae? aiao?eaeoe/iiai oieo, ea?eiai- oa a?iioiniacio, oe??ieo i?iya?a, ye? ca aeaieie aea?aieia?/iiai aiaiiaco oa oano?a in vitro aeieeaee aiane?aeie canoinoaaiiy oaeeo i?aia?ao?a, ye ae?iaae?ie, ao?ii?i (i?aia?aoe aeey i?aiaaeeeaoe??), o?iiaioae, n?aacii, eae?inie, oaioai?e (i?aia?aoe aeey oa?aeiiai oa aac?n ia?eico), iiaiea?i, e?aeiea?i (aioeno?ani?i? iaaeeeaiaioici? niieoee). Oaeoi?aie, ye? cia/ii iineeththoue ?ecee ?icaeoeo IA o ianoaaeaieo aoee aiaeio?aoaaeueiee ia?eic, iaoyaeaiee aea?aieia?/iee aiaiiac oa niaaeeia?noue ii AC, o?eaaea aaeeaaiiy e?e?a, iiaoi?i? iia?aoeai? ao?o/aiiy oiui. Iaea?eueo ?ioi?iaoeaieie a ae?aaiinoeoe? IA ? eiiieaen iaoiae?a aea?aieia?/iiai eaai?aoi?iiai aeine?aeaeaiiy (?aaeoe?y aeaa?aioeyoe?? iianenoeo ee?oei ca Oaee?,iieaciee iioeiaeaeaiiy iaeo?io?e?a,?aaeoe?y ?ia?a?oe?? i?a?aoe?? eaeeioeeo?a) oa iaoiae ?ioiioa?i?noiiao???. Iniiaieie ?ioiieia?/ieie iniaeeainoyie IA o a?aeiia?aeii? eaoaai??? in?a ? aenieee ??aaiue IgE oa iieacieea AAN-?OE, iecuee?e ??aaiue aaniethoii? oa a?aeiinii? e?eueeino? oaio?e?i-/ooeeai? noaiiioeyoe?? A-?OE, i?aeaeuaiiy ?ioii?aaoeyoi?iiai ?iaeaeno. Aaaeeeaa cia/aiiy a ee?i?/i?e ?ioiieia?? oa aea?aieia?? ia? i?iaeaia i?io?eaeoeee IA o ??cieo eaoaai??e oai?eo, ae??oaiiy yei? iiaeia iaaeeceoe oeyoii i?iaiicoaaiiy ?eceeo ?icaeoeo IA o a?aeiia?aeieo in?a. I?e oeueiio ca aeiiiiiaith naeaaioe?aeueiiai noaoenoe/iiai aiae?co iaie aecia/aii, ui oao?aoeyi i?e i?aeaioiaoe? oai?iai aei iia?aoeaiiai ao?o/aiiy ?c canoinoaaiiyi aianoac?ieia?/iiai caaacia/aiiy iniaeeai ne?ae a?aoiaoaaoe ieaioaaiiy i?iaaaeaiiy aiaeio?aoaaeueiiai oeio ia?eico, iaoyaeaio niaaeeia?noue ii AC, iayai?noue ee?i?/ieo iciae AC, aeia/ieai’yii? oai?iae, i?enooi?noue iciae aea?a?? i?e eaai?aoi?iiio ianoaaeaii? e?ia?, a?ia?/ooeeaino? aei iaaeeeaiaioicieo aea?aai?a oiui (oaaeeoey 1). Oaaeeoey 1 I?aenoieiaa oaaeeoey oaeoi??a ?eceeo aeey i?iaiicoaaiiy iaaeeeaiaioicii? aea?a?? i?ae /an i?iaaaeaiiy ia?eico . Iaioa cia/aiiy iathoue noaoue ? a?e ianoaaeaieo, iayai?noue a aiaiiac? IA, ia?aianaieo iia?aoe?e i?ae ia?eicii a ieioeiio, o?eaaea aaeeaaiiy e?e?a, iayai?noue caoai?thaaiue na?oeaai-noaeeiii? oa aeeoaeueii? nenoai oiui. Oaeei /eiii, canoinoaaiiy naeaaioe?aeueiiai noaoenoe/iiai aiae?co aeicaiey? (o aecia/aiiio nooiai?) ia’?aeiaoe o eiiieaen ??ci? aeci- ? aiaeiaaii? ia?aaeoiiae aeey aecia/aiiy ??aiy ?eceeo aeieeiaiiy IA o eiie?aoieo iaoe??io?a, ui ia? aaaeeeaa cia/aiiy aeey i?aeoe/ii? ioi?iie caei?ia’y, i?io?eaeoeee IA na?aae oai?eo, ye? aioothoueny aei iia?aoeaiiai ao?o/aiiy i?ae caaaeueiith aianoac??th. Caaa?ooth/e aiae?c ?acoeueoao?a aeine?aeaeaiiy iaiao?aeii aeacaoe, ui io?eiai? iaie aeai? i?i /anoioo, ao?ieia?/io no?oeoo?o, ee?i?ei-?ioiieia?/i? iniaeeaino? IA a aianoac?ieia?/i?e i?aeoeoe?, iiaeeeaino? ?? i?iaiicoaaiiy ? iiaeie aeey Oe?a?ie ? iiaeooue aooe canoiniaai? o i?aeoe/i?e ae?yeueiino? oao?aoe?a ?ioiieia?a, aea?aieia?a oa aianoac?ieia?a. AENIIAEE 1. *anoioa iaaeeeaiaioicii? aea?a?? o oai?eo, ui i?aeaeaeeny iia?aoeaiiio ao?o/aiith c aeei?enoaiiyi ??cieo aeae?a aianoac??, neeaaea? ca ?acoeueoaoaie aiae?co iaoa??ae?a ?noi??e oai?ia a?aeiia?aeieo eaoaai??e iaoe??io?a 5.13%, a i?e canoinoaaii? aiaeio?aoaaeueiiai ia?eico - 9.77%. 2. ?ecee aeieeiaiiy iaaeeeaiaioicii? aea?a?? o in?a , ui i?aeeyaathoue aianoac?ieia?/iiio caaacia/aiith, cia/ii i?aeaeuothoue o?eaaea aaeeaaiiy e?e?a (aioea?ioee?a, a?oai?i?a, aiaeaaoee?a, niaciie?oee?a), noiooi? aea?a?/i? caoai?thaaiiy (a?iio?aeueia anoia, aea?a?/iee ?ei?o, aea?iaoeo, iie?iic ), iaoyaeaia niaaeeia?noue ii aea?a?/iei caoai?thaaiiyi, iayai?noue aeia/ieai’yii? oai?iae, o?ii?/ieo ianiaoeeo?/ieo caoai?thaaiue i?aai?a aeeoaiiy, iiaoi?ieo iia?aoeaieo ao?o/aiue ?c canoinoaaiiyi aianoac??. 3. Ia?aaaaeieie oi?iaie iaaeeeaiaioicii? aea?a?? o oai?eo, ui i?aeaeaeeny aianoac?ieia?/iiio caaacia/aiith, ca?aeii aeanieo niinoa?aaeaiue, ? aiao?eaeoe/iee oie (57.89%), ea?eiai- oa a?iioiniaci (26.32%). Oe??i? i?iyae iaaeeeaiaioicii? aea?a?? cono??/athoueny ??aeoa (15.79% aeiaaee?a). 4. Ca aeaieie ee?i?ei-eaai?aoi?ieo iaoiae?a aeine?aeaeaiiy na?aae iaaeeeaiaioicieo aea?a?/ieo ?aaeoe?e o in?a, ui i?aeaeaeeny aianoac??, ia?aaaaeathoue ?aaeoe?? aiao?eaeoe/iiai oeio. 5. Ao?ieia?/ieie /eiieeaie iaaeeeaiaioicii? aea?a?? o in?a, ui caciaee aianoac??, ? iaaeeeaiaioici? caniae aeey i?aiaaeeeaoe?? (ae?iaae?ie, ao?ii?i), aianoaoeee (o?iiaioae, eae?inie), aoa?aeoee (n?aacii), aioeno?ani?i? caniae (e?aeiea?i, iiaiea?i). A 49.0% aeiaaee?a o oai?eo aeyaey?oueny a?ia?/ooeea?noue aei 2-3 i?aia?ao?a iaeii/anii. 6. Aeey in?a c iaaeeeaiaioiciith aea?a??th, ui aeieeea aiane?aeie iia?aoeaiiai ao?o/aiiy i?ae aianoac??th, i?eoaiaii? aeieeiaiiy eiia?iiaaieo ii?ooaiue ?ioi?oaoo (cieaeaiiy i?e?iaeiuei? ?acenoaioiino?, iieaciee?a O-eaiee e?ioioeeo?a oa ?o ooieoe?e, ?ioii?aaoeyoi?i? ii?ooaiiy) c ia?aaaaith iciae aea?a?? (a?ia?i?iaeoeoe?y A-e?ioioeeo?a, aenieee ??aaiue IgE, i?aeaeuaiiy ?ioii?aaoeyoi?iiai ?iaeaeno, iiceoeai? oanoe in vitro c iaaeeeaiaioicieie aea?aaiaie). 7. Aeei?enoaiiy i?aenoieiai? oaaeeoe? oaeoi??a ?eceeo iaaeeeaiaioicii? aea?a??, yea iaea?aeaia ca aeiiiiiaith naeaaioe?aeueiiai noaoenoe/iiai aiae?co, aeicaiey? i?iaiicoaaoe ?ecee aeieeiaiiy iaaeeeaiaioicii? aea?a?? o oai?eo, ui i?aeeyaathoue aianoac?ieia?/iiio caaacia/aiith. I?AEOE*I? ?AEIIAIAeAOe?? 1. E?ea?yi aea?aieiaai ? aianoac?ieiaai iaiao?aeii iaoe ia oaac?, ui iaaeeeaiaioicia aea?a?y o in?a, ui i?aeaeathoueny iia?aoeaiiio ao?o/aiith i?ae aianoac??th, ?icaeaa?oueny nooo?ai /ano?oa (5.13%), i?ae na?aae iiioeyoe?? ianaeaiiy a oe?eiio (2.24%), iniaeeai i?e aeei?enoaii? aiaeio?aoaaeueiiai ia?eico (9.77% niinoa?aaeaiue). 2. C iaoith ?aeaioeo?eaoe?? iaaeeeaiaioicieo aea?aai?a o in?a, ui i?aeeyaathoue aianoac??, iaiao?aeii aeei?enoiaoaaoe cae?aiiy aea?aieia?/iiai aiaiiaco, aea?aieia?/i? i?ia??i/i? oanoe (?aaeoe?y aeaa?aioeyoe?? iianenoeo ee?oei ca Oaee?, iieaciee iioeiaeaeaiiy iaeo?io?e?a, ?aaeoe?y ?ia?a?oe?? i?a?aoe?? eaeeioeeo?a) ? iniaeeai iaoiae ?ioiioa?i?noiiao??? c a?aeiia?aeieie aea?aaiaie. 3. C iaoith ?aeaioeo?eaoe?? iaaeeeaiaioicieo aea?aai?a o in?a, ui i?aeeyaathoue aianoac??, ia ?aeiiaiaeo?oueny aeei?enoiaoaaoe oe??i? i?iae c a?aeiia?aeieie iaaeeeaiaioicieie i?aia?aoaie o ca’yceo c ?o iaaeinoaoiueith ?ioi?iaoeai?noth, iaaacia/i?noth aeey oai?eo (iiaeeea?noue ?icaeoeo aiao?eaeoe/iiai oieo, ?icaeoie aeiaeaoeiai? nainea?e?caoe?? oiui). 4. O ?ac? aeieeiaiiy iia?/ii? ae?? iaaeeeaiaioicieo i?aia?ao?a o in?a, ui i?aeaeaeeny aianoac??, iaiao?aeii i?iaiaeeoe aeeoa?aioe?eio ae?aaiinoeeo i?ae oiene/ieie, inaaaeiaea?a?/ieie ? ni?aaaei?ie aea?a?/ieie ?aaeoe?yie ca aeiiiiiaith iaaaaeaieo a iao?e ?iaio? e?eoa???a. 5. E?ea?yi o??o?aai oa aianoac?ieiaai ia?aae i?iaaaeaiiyi iia?aoeaiiai ao?o/aiiy c aeei?enoaiiyi aianoac?? iaiao?aeii aecia/eoe o eiaeiiai oai?iai ??aaiue ?eceeo aeieeiaiiy iaaeeeaiaioicii? aea?a?? i?ae /an aianoac?ieia?/iiai caaacia/aiiy ca aeiiiiiaith ?ic?iaeaiiai iaie aeai?eoio ?c canoinoaaiiyi naeaaioe?aeueiiai noaoenoe/iiai aiae?co, yeee ai?uo?: - cae?aiiy aiaiiaco aeeooy (iayai?noue aeia/ieai’yii? oai?iae oa ia?aianaieo a aiaiiac? iia?aoe?e i?ae ia?eicii); - cae?aiiy aea?aieia?/iiai aiaiiaco (iayai?noue iaoyaeaii? niaaeeia?no? ii aea?a?/iei caoai?thaaiiyi, iayai?noue a aiaiiac? iaaeeeaiaioicii? aea?a??); - o?ce/ia ianoaaeaiiy (iayai?noue ee?i?/ieo iciae aea?a?/ieo caoai?thaaiue); - i?iaiicoaaiiy i?iaaaeaiiy aiaeio?aoaaeueiiai ia?eico. I?e iayaiino? aeuaia?a?aoiaaieo iciae aaaeaii i?iaanoe eaai?aoi?ia aea?aieia?/ia oa ?ioiieia?/ia ianoaaeaiiy. Aeey in?a c aenieei ?eceeii ?icaeoeo iaaeeeaiaioicii? aea?a?? i?ae /an aianoac?? oa?aeoa?i? aenieee ??aaiue IgE, a?ia?i?iaeoeoe?y A-eeioioeeoia, i?aeaeuaiiy ?ioii?aaoeyoi?iiai ?iaeaeno, iiceoeai? ?acoeueoaoe oano?a in vitro c iaaeeeaiaioicieie aea?aaiaie. Aeae? oao?aaoeue ?c canoinoaaiiyi i?aenoieiai? oaaeeoe? aeey i?iaiicoaaiiy iaaeeeaiaioicii? aea?a?? i?ae /an i?iaaaeaiiy ia?eico ioe?ith? ?ioi?iaoeai?noue iciae, ui aeyaeai?, a aaeao. I?e oeueiio yeoi noia aae?a ia?aaeuo? 27, oi o aeaiiai iaoe??ioa aenieee ?ecee aeieeiaiiy iaaeeeaiaioicii? aea?a?? i?ae /an i?iaaaeaiiy ia?eico, ui iio?aao? i?iaaaeaiiy a?aeiia?aeieo caaaeueiia?aeiieo i?io?eaeoe/ieo caoiae?a (i?aea?? iaaeeeaiaio?a aeey i?iaaaeaiiy ia?eico ?c canoinoaaiiyi aea?aieia?/ieo i?ia in vitro, aeeiiaiiy i?aiaaeeeaoe?? ?c canoinoaaiiyi aetheiei?oeeinoa?i?ae?a, aeieaoi??a I1 a?noai?iiaeo ?aoeaioi??a (ca 16-24 aiaeei oa ca 30 oaeeei aei i?iaaaeaiiy ia?eico), iioei?caoe?? ia’?io oee?eoethth/i? e?iae, i?e iiaeeeaino? i?iaaaeaiiy aeueoa?iaoeaiiai aei aiaeio?aoaaeueiiai ia?eico oeio aianoac?ieia?/iiai caaacia/aiiy. IA?AE?E ?IA?O, UI IIOAE?EIAAI? II OAI? AeENA?OAOe?? 1. Aeioece/aneea iaoiaeu aeeaaiinoeee aeia?/oanoaeoaeueiuo ?aaeoeee / N.A.Caeeia,A.A.Caeeiaa,O.A.Eeneiuoe,A.E.Aa?aeiie / ?ioiieia?y oa aea?aieia?y.-1998.-?1-2.-N.104-108. 2. Aa?a?iie A.?., Caeeia N.A. *anoioa ? no?oeoo?a iaaeeeaiaioicii? aea?a?? a aianoac?ieia?/i?e i?aeoeoe?//?ioiieia?y oa aea?aieia?y.-1998. -?4.-N.74-76. 3. Aa?a?iie A.?. I?iaiicoaaiiy ?eceeo aeieeiaiiy iaaeeeaiaioicii? aea?a?? i?e i?iaaaeaii? ia?eico//A?niee A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.-1999.-?3.-C.5-6. 4. Aa?a?iie A.?., Caeeia N.A. I?iaeaia iia?/ii? ae?? iaaeeeaiaioicieo i?aia?ao?a a aianoac?ieia?? //E?ee Oe?a?ie. - 1999.- ?5.-N.44-45. 5. *anoioa oa no?oeoo?a iaaeeeaiaioicii? aea?a?? i?e aianoac?ieia?/iiio ao?o/aii? /A.?.Aa?a?iie, N.A.Caeeia, E.N.Ineiiaa, I.A. Iaca? / Ca??iee iaoeiaeo i?aoeue ni?a?ia?oiee?a EIAII ?i.I.E.Ooieea. - 1998. Aei.7.- Ei.1. -N.181-184. 6. Eiioiioa?ienoiiao?ey - iaoiae yeni?ann - aeeaaiinoeee aeea?aee /N.A.Caeeia, O.A.Eeneiuoe, A.E.Aa?aeiie, N.E.AEieeaaneee//I iaoe?iiaeue- iee eiia?an Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe??: Ca??ea oac.-Aeoooa,1998.-N.11-12. 7. Eiioiioa?ienoiiao?ey - iaoiae yeni?ann - aeeaaiinoeee aeia?/oanoaeoaeueiuo ?aaeoeee o eeoe n ?anie?aoi?iuie aea?ae/aneeie caaieaaaieyie /O.A.Eeneiuoe, N.A.Caeeia, A.A.Caeeiaa, A.E.Aa?aeiie// II C’?cae ooec?ao??a ? ioeueiiiieia?a Oe?a?ie:Ca??ea oac.-Ee?a,1998.-N.131. Aa?a?iie A.?. *anoioa, ee?i?ei-?ioiieia?/i? iniaeeaino? oa i?iaiicoaaiiy iaaeeeaiaioicii? aea?a?? o in?a, ui i?aeaeaeeny aianoac??.-?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.29 - ee?i?/ia ?ioiieia?y.- ?inoeooo ooec?ao??? ? ioeueiiiieia?? ?i.O.A.ssiianueeiai AII Oe?a?ie, Ee?a, 1999. I?aaenoaaeaia aei caoenoo aeena?oaoe?y o aeaeyae? ?oeiieno oa 6 iaoeiaeo ioae?eaoe?e, ye? i?noyoue aeai? ee?i?/iiai, ?ioiieia?/iiai, aea?aieia?/iiai oa a?io?ce/iiai ianoaaeaiiy oai?eo ia iaaeeeaiaioicio aea?a?th, yea aeieeea i?ae /an i?iaaaeaiiy ia?eico. Aoee i?iaiae?ciaai? /anoioa, no?oeoo?a, oaeoi?e ?eceeo, ee?i?ei-?ioiieia?/i? iniaeeaino? iaaeeeaiaioicii? aea?a?? i?ae /an i?iaaaeaiiy ??cieo aeae?a aianoac?? oa iiaeeea?noue ?? i?iaiicoaaiiy. Anoaiiaeaii, ui na?aae canoiniaaieo i?ae /an o??o?a?/iiai e?eoaaiiy ??cieo aeae?a aianoac?? (2063 aeiaaee?a) ?icaeoie iaaeeeaiaioicii? aea?a?? niinoa??aaany /ano?oa i?ae /an i?iaaaeaiiy aiaeio?aoaaeueiiai ia?eico (9.77%), a iniiaiiio o oi?i? aiao?eaeoe/iiai oieo. Iineiae?iiiee aiae?c aeaieo ?ioiieia?/iiai ianoaaeaiiy iieacaa, ui ?icaeoie iaaeeeaiaioicii? aea?a?? i?ae /an ia?eico noi?iaiaeaeoaaany aino?ith eiia?iiaaiith ?ioiiith iaaeinoaoi?noth c iciaeaie aea?a??. Aeyaeaii, ui na?aae aioeaaiieo /eiiee?a iaaeeeaiaioicii? aea?a?? ia?aaaaeaee iaaeeeaiaioici? caniae aeey i?aiaaeeeaoe??, aianoaoeee, aoa?aeoeee, aioeno?ani?i? caniae. Ca aeiiiiiaith naeaaioe?aeueiiai noaoenoe/iiai aiae?co aeiaaaeaia iiaeeea?noue i?iaiicoaaiiy ?eceeo aeieeiaiiy iaaeeeaiaioicii? aea?a?? i?ae /an i?iaaaeaiiy ia?eico. Eeth/ia? neiaa: aianoac?y,aiaeio?aoaaeueiee ia?eic, i?iaiicoaaiiy iaaeeeaiaioicii? aea?a??. Barvinok A.I. Frequency, clinical and immunological peculiarities and drug allergy prognosis at patients under anaesthesia.-Manuscript. Thesis presentation for the degree of Master of Medicine by specialization 14.01.29-clinical immunology.-Institute of Phthisiology and Pulmonology n.a. F.G.Yanovsky, Ukrainian Academy of Medical Sciences,Kiev,1999. This master’s thesis consists of a copy 6 scientific publications, containing clinical, immunological, allergological and biophysical investigation of patients with regard to drug allergy arising during narcosis. Drug allergy frequency, structure, risk factors, clinical and immunological peculiarities, prognosis possibility were thoroughly analysed. It was established that during different kinds of anaesthesia (2063 cases) there arised drug allergy prevalently during endotracheal narcosis (9.77%). Anaphylactic shock was the main form of drug allergy. According to the datas of immunological investigation the development of drug allergy accomponies by acute combined immunological insufficiency with allergy signs prevalence. It was found out that among antigens of drug allergy during anaesthesia such remedies as hypnotics, antistressorics and remedies for premedication predominated. Using free distributional test the possibility to prognose the risk of drug allergy arising during narcosis was proved. Key words: anaesthesia,endotracheal narcosis,prognosis of drug allergy. Aa?aeiie A.E. *anoioa, eeeieei-eiioiieiae/aneea iniaaiiinoe e i?iaiice?iaaiea eaea?noaaiiie aeea?aee o eeoe, iiaeaa?aoeony aianoacee.-?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.29 - eeeie/aneay eiioiieiaey.- Einoeooo ooeceao?ee e ioeueiiiieiaee ei.O.A.ssiianeiai AII Oe?aeiu, Eeaa,1999. I?aaenoaaeaia e caueoa aeenna?oaoeey a aeaea ?oeiiene e 6 iao/iuo ioaeeeaoeee, eioi?ua niaea?aeao ?acoeueoaoe eeeie/aneeo, eiioiieiae/aneeo, aeea?aieiae/aneeo e aeioece/aneeo enneaaeiaaiee iaoeeaioia n eaea?noaaiiie aeea?aeae, eioi?ay aicieeea ai a?aiy i?iaaaeaiey ia?eica. N iiiiuueth i?iaaaeaiiiai ?ao?iniaeoeaiiai (1637 iaoeeaioia) e nianoaaiiiai (426 iaoeeaioia) enneaaeiaaiee auee i?iaiaeece?iaaiu /anoioa, no?oeoo?a, oaeoi?u ?enea, eeeieei-eiioiieiae/aneea iniaaiiinoe eaea?noaaiiie aeea?aee i?e ?acee/iuo aeaeao aianoacee e aiciiaeiinoue a? i?iaiice?iaaiey. Onoaiiaeaii, /oi i?e i?iaaaeaiee ?aciuo aeaeia aianoacee (ianoiia iaacaieeaaiea, aioo?eaaiiay aianoacey, nieiiiiicaiaay aianoacey, yiaeio?aoaaeueiee ia?eic) ?acaeoea eaea?noaaiiie aeea?aee (5.13% neo/aaa) iaaethaeaeinue i?aeiouanoaaiii ai a?aiy i?iaaaeaiey yiaeio?aoaaeueiiai ia?eica (9.77% neo/aaa), /oi cia/eoaeueii i?aauoaei o?iaaiue ?ani?ino?aiaiiinoe eaea?noaaiiie aea?aee n?aaee ianaeaiey Aeiieoeeie iaeanoe (2.24%). Eco/aiu no?oeoo?a eaea?noaaiiie aeea?aee ai a?aiy i?iaaaeaiey ia?eica e a? eeeieei-eiioiieiae/aneea iniaaiiinoe. A no?oeoo?a eaea?noaaiiie aeea?aee aaaeouaa ianoi caieiae aiaoeeaeoe/aneee oie (57.89%), ea?eiai- e/eee a?iioiniaci (26.32%), ?aaea ioia/aeenue eiaeiua i?iyaeaiey eaea?noaaiiie aeea?aee (15.79%). ?acoeueoaou eiioiieiae/aneiai ianeaaeiaaiey iaoeeaioia iinea i?iaaaeaiey oe?o?ae/aneiai aiaoaoaeuenoaa n eniieueciaaieai yiaeio?aoaaeueiiai ia?eica auyaeee ?acaeoea o ieo ino?ie eiiaeie?iaaiiie eiioiiie iaaeinoaoi/iinoe n i?aiaeaaeaieai i?eciaeia aeea?aee, eioi?ua oa?aeoa?eciaaeenue iiauoaieai o?iaiy IgE, iieacaoaey AAN-?IE, eiioii?aaoeyoi?iiai eiaeaena, nieaeaieai o?iaiy oaioeeei-/oanoaeoaeueiie noaiiioeyoeee A-?IE. Ii aeaiiui eeeieei-eaai?aoi?iuo iaoiaeia enneaaeiaaiee n?aaee iaoeeaioia n eaea?noaaiiie aeea?aeae ai a?aiy i?iaaaeaiey ia?eica i?aiaeaaeaee ?aaeoeee aiaoeeaeoe/aneiai oeia. Aeey aeeaaiinoeee i?e/eiii cia/eiuo eaea?noaaiiuo aeea?aaiia iaie eniieueciaai eiiieaen aeea?aieiae/aneeo iaoiaeia, eioi?ue aeeth/ae a naay nai? aeea?aieiae/aneiai aiaiiaca, oanou in vitro ( ?aaeoeey aeaa?aioeyoeee aacioeeia ii Oaeee, iieacaoaeue iia?aaeaeaaiinoe iaeo?ioeeia, ?aaeoeey eiaeaeoeee iea?aoeee eaeeioeeoia, iaoiae eiioiioa?ienoiiao?ee). A ?acoeueoaoa i?iaaaeaiiiai aeea?aieiae/aneiai ianeaaeiaaiey ioia/aii, /oi n?aaee eaea?noaaiiuo aeea?aaiia i?aiaeaaeaee n?aaenoaa aeey i?aiaaeeeaoeee (aeeiaae?ie, ao?iiei), aianoaoeee (oeiiaioae, eaeeinie), aoa?aeoee (neaacii), aioeno?anni?iua i?aia?aou (eeaeieaei, iiaieaei). N oeaeueth i?iaiice?iaaiey ?enea aicieeiiaaiey eaea?noaaiiie aeea?aee ai a?aiy aianoacee iaie auea i?iaaaeaia iineaaeiaaoaeueiay aeeaaiinoe/aneay i?ioeaaeo?a, yaeythuayny iniiaie naeaaioeeaeueiiai aiaeeca. Aeinoiaa?ioth aeeaaiinoe/aneoth oeaiiinoue aeey i?iaiice?iaaiey ?enea ?acaeoey eaea?noaaiiie aeea?aee ai a?aiy ia?eica eiatho ieaie?iaaiea i?iaaaeaiey yiaeio?aoaaeueiiai oeia ia?eica, ioyaiuaiiay ianeaaenoaaiiinoue ii aeea?ae/aneei caaieaaaieyi, iaee/ea niioonoaothueo aeea?ae/aneeo caaieaaaiee, aeae/aeaiaiiie aieacie, i?eciaeia aeea?aee i?e eaai?aoi?iii eiioiieiae/aneii ianeaaeiaaiee, aeia?/oanoaeoaeueiinoe e eaea?noaaiiui aeea?aaiai. Onoaiiaeaii, /oi iie e aic?ano ianeaaeoaiuo, ia?aianaiiua iia?aoeee iiae ia?eicii a i?ioeii, aeeeoaeueiue i?eai eaea?noa, iaee/ea caaieaaaiee na?aea/ii-ninoaeenoie e aeuoaoaeueiie nenoai eiatho iaiueoaa cia/aiea. N iiiiuueth naeaaioeeaeueiiai noaoenoe/aneiai aiaeeca ?ac?aaioaia aaeueiay ioeaiea oaeoi?ia ?enea eaea?noaaiiie aeea?aee, aeieacaia aiciiaeiinoue a? i?iaiice?iaaiey, /oi iicaieeo inouanoaeoue i?ioeeaeoeeo eaea?noaaiiie aeea?aee o aieueiuo iiaeeaaeaueo iia?aoeaiiio aiaoaoaeuenoao iiae ia?eicii. Eeth/aaua neiaa: aianoacey, yiaeio?aoaaeueiue ia?eic, i?iaiice?iaaiea eaea?noaaiiie aeea?aee.

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