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?INOEOOO OOEC?AO??? ? IOEUeIIIIEIA???i. O.A.ssIIANUeEIAIAEAAeAI??
IAAeE*IEO IAOE OE?A?IE

AAO Eany Aanee?aia

OAeE:616.248-053.6–092-08

A?IIO?AEUeIA ANOIA O Ae?OAE IOAA?OAOIIAI A?EO: INIAEEAINO?
IAOIAAIACO,IA?AA?AO ? E?EOAAIIss

14.01.27. – ioeueiiiieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyaeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
Aeaieea Aaeeoeueeiai IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, i?ioani? EANEOess Ieueaa ?ea??ii?aia, Ee?anueea
iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,
caa?aeoaa/ eaoaae?e iaae?ao??? ? 1.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? OOAA Iaii?ea Ieoaee?aia, Ee?anueea
iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,
i?ioani? eaoaae?e oa?ai?? oa ?aaiaoieia??;

aeieoi? iaaee/ieo iaoe, i?ioani? IA?OeAAA Oaoyia Ieaen??aia,
Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie, caa?aeoaa/
eaoaae?e oaeoeueoaonueei? oa?ai?? oa aiaeie?eiieia??;

aeieoi? iaaee/ieo iaoe IICAEAANUeEEE Aiaoie?e Oaiaein?eiae/, ?inoeooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, caa?aeoaa/
a?aeae?eaiiy caoai?thaaiue i?aai?a aeeoaiiy.

I?ia?aeia onoaiiaa:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey (i. Ee?a),
eaoaae?a iaae?ao??? ? 4.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “__01____” ___11 1999 ?ieo i
_14__ aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.552.01
i?e ?inoeooo? ooec?ao??? ? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII
Oe?a?ie ca aae?anith: 252110, i. Ee?a, INI-680, oca?c I?ioan?a ss?, 7.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?inoeoooo ooec?ao???
? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie ca aae?anith (252110,
i. Ee?a, oca?c I?ioan?a ss?, 7).

Aaoi?aoa?ao ?ic?neaiee “ _30_ ” ____09____ 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee AE.A.Aaaioe?aa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia a?iio?aeueii? anoie iei? noi?oue
iaaecae/aeii aino?i. *anoioa oeueiai caoai?thaaiiy c ?ieo a ??e
iaooeeueii c?inoa?. Ca ?acoeueoaoaie iiioeyoe?eieo ai?aeai?ieia?/ieo
aeine?aeaeaiue, iioe?ai?noue a?iio?aeueii? anoie a a?eueoino? e?a?i
na?oo eieeaa?oueny a na?aaeiueiio ia ??ai? 3-7 % (Oauaiei TH.?., 1997).

Iniaeeai o?eaiaeiith ? neooaoe?y c aeeoy/ith anoiith, iioe?ai?noue yei?
a ??cieo iiioeyoe?yo eieeaa?oueny iaeaea a?ae 0 % aei 30 %. *anoioa
oeueiai caoai?thaaiiy na?aae ae?oae O?aioe?? noaiiaeoue 7 %, Aiae?? –
11 %, NOA – 13 %, Aano?ae?? – 7-10 %, Iiai? Caeaiae?? – 8 %, ??eaiae?? –
35 %, ?in?? – 10 % (Gergen P.J., et al., 1988; Pararajasingam C.D. et
al., 1992; Eaaaiia N.TH., 1995). Ia aeaeue, nueiaiaei? i?aeoe/ii
a?aenooi? aeinoia??i? aeai? noiniaii /anoioe a?iio?aeueii? anoie na?aae
ae?oae Oe?a?ie. A?eueo?noue aeine?aeiee?a aea/aee iioe?ai?noue oeueiai
caoai?thaaiiy ia i?aenoaa? caa?oaiue ca iaaee/iith aeiiiiiaith, ui ca
ia’?eoeaieo oiia ia a?aeia?aaea? ni?aaaeith neooaoe?th ? cia/ii caieaeo?
iieacieee (?e?iiaa ?.?., 1995; Oauaiei TH.?., 1997). ? eeoa inoaii?i
/anii iioae?eiaai? ia?o? ?acoeueoaoe na?eicieo oe?eani?yiiaaieo
ee?i?ei-ai?aeai?ieia?/ieo aeine?aeaeaiue, ye? a 2,5-3 ?ace ia?aaeuothoue
iieacieee io?oe?eii? noaoenoeee. Oae? ??ci? i?aeoiaee aei aea/aiiy
ai?aeai?ieia?? anoie, a oaeiae ?yae ?ioeo ia’?eoeaieo oaeoi??a
iiyniththoue eieeaaiiy /anoioe oeueiai caoai?thaaiiy na?aae ae?oae
Oe?a?ie a?ae 0,9 % aei 6,7 % (o na?aaeiueiio – 2,8 %) (Eaneoey I.?.,
1996).

I?iaeiaaeo? c?inoaoe /anoioa aaaeeeo oi?i a?iio?aeueii? anoie, ia?anoaee
aooe aeiyoeii aeiaaeee nia?o? ae?oae, ni?iaieiaai? oe??th iaaeoaith
(Eaaaiia N.TH., 1993; Caaieioneeo O.A. e ae?., 1997)

Aaeeea e?euee?noue ??ciiiai?oieo iaaee/ieo i?aai?caoe?e o anueiio na?o?
i?aoeth? iaae ?ica’ycaiiyi i?iaeai a?iio?aeueii? anoie. ?iaioa oey
eii?aeeio?oueny I?aeia?iaeiith a?oiith niaoe?ae?no?a – aenia?o?a c
i?iaeai anoie, yea iaiaaa?oueny ?ic?iaeoe ?aeei? aeey an?o e?a?i
i?aeoiaee aei ae?aaiinoeee ? e?eoaaiiy oeueiai aaaeeiai caoai?thaaiiy.

Aea, iacaaaeath/e ia oae? aeiaaeuei? ? a?oioiai? aeine?aeaeaiiy, anoia ?
iei? caeeoa?oueny iaoieia??th c aaaaoueia iac’yniaaieie ieoaiiyie.
Cie?aia, iaaeinoaoiuei aea/aieie ? iniaeeaino? ia?aa?ao oeueiai
caoai?thaaiiy o ae?oae ioaa?oaoiiai a?eo. A?aeiii, ui oeae ia??iae
aeeoeinoaa iaeaaeeoue aei e?eoe/ieo ia??iae?a iioiaaiaco ethaeeie, eiee
i?aai?ci anooia? o /an noaoaaiai aeic??aaiiy ? iieiy?oueny ia?aae iiaei
o?c?ieia?/iei no?eaeii e?euee?niiai ? ye?niiai ?inoo oa ??cei?
ia?aaoaeiae ooieoe?e iaeaea an?o i?aai?a ? nenoai (Ia?e?i E.A. oa ?i.,
1996).

?niothoue aeai? i?i oa, ui o 2/3 ae?oae anoia a ioaa?oaoiiio ia??iae?
ci?ith? na?e ia?aa?a (?eoi?ia N.E. oa ?i., 1986; ?eue?i A.A. oa ?i.,
1986; Iaee?ia E.A., 1993; Balfour-Lunn L., 1985; Gern J.E. et al., 1995;
Kintner E., 1997). Iaeiae, oe? ?iaioe iiiaeeiie? ? ia aeathoue
oe?e?niiai oyaeaiiy i?i i?e/eie, ye? coiiaeththoue ci?io ee?i?ee
a?iio?aeueii? anoie a i?aee?oeiaiio a?oe?. Aeeneon?eieie caeeoathoueny
ieoaiiy no?aoaa?? e?eoaaiiy. Iniaeeai oea noino?oueny i?iaeai
ai?iiiaeueii? oa?ai?? ? ?? aieeao ia ?ai?iaeoeoeaio ooieoe?th o
iaeaooiueiio.

Aeacaia aeua neooaoe?y aecia/eea aeooaeuei?noue ? iaoo iaoiai
aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? a
iaaeao iaoeiai? oaiaoeee eaoaae?e iaae?ao??? ? 1 Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe “Ee?i?ei-iaoiaaiaoe/i? aa??aioe ?
aoaeoeai?noue oa?ai?? ?ani??aoi?ieo aea?aic?a o a?eiaiio aniaeo?”, ?
aea?ae?a?no?aoe?? OA-01013633?, ia?a?a?no?iaaia 12/3-1241 a?ae 5.10.92.

Iaoa aeine?aeaeaiiy. ?ic?iaeoe i?ia?aie e?eoaaiiy a?iio?aeueii? anoie o
ae?oae ioaa?oaoiiai a?eo ia i?aenoaa? eiiieaeniiai aea/aiiy iniaeeainoae
iaoiaaiaco, ee?i?ee oa ia?aa?ao caoai?thaaiiy.

A?aeiia?aeii aei iinoaaeaii? iaoe aecia/ai? oae? caaaeaiiy
aeine?aeaeaiiy:

1. Aea/eoe i?e/eie aeieeiaiiy ? ?icaeoeo a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo.

2. I?iaiae?coaaoe ee?i?/i? iniaeeaino? ia?aa?ao a?iio?aeueii? anoie o
ae?oae oe??? a?eiai? a?oie.

3. I?iaanoe ioe?ieo ai?iiiaeueiiai, ?ioiieia?/iiai e aea?aieia?/iiai
noaoono o oe?e a?oi? ae?oae.

4. I?iaiae?coaaoe aieea ai?iiiaeueiiai aeenaaeaino ia ia?aa?a
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo.

5. ?ic?iaeoe ? ai?iaaaeeoe o i?aeoeeo ae?aaiinoe/i? e?eoa??? aaaeeino?
ia?aa?ao a?iio?aeueii? anoie o ae?oae oe??? a?eiai? a?oie.

6. ?ic?iaeoe niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo aaaeei?
oi?ie a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo.

7. Ia i?aenoaa? io?eiaieo aeaieo ?ic?iaeoe eiiieaeniee ieai caoiae?a ?
i?aeoe/i? ?aeiiaiaeaoe?? aeey e?eoaaiiy a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo.

8. Aea/eoe aeeiai?eo caoai?thaaiiy ia oii? aeei?enoaiiy cai?iiiiiaaieo
i?ia?ai e?eoaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa a Oe?a?i? i?iaaaeaia eiiieaenia aea/aiiy iniaeeainoae ia?aa?ao
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo. Aecia/ai? i?e/eie e
iniiai? iaoiaaiaoe/i? eaiee, ui i?ecaiaeyoue aei ci?ie ee?i?/iiai
ia?aa?ao oeueiai caoai?thaaiiy a ia??iae noaoaaiai aeic??aaiiy. Aia?oa
iieacai? a?aei?iiino? ee?i?ee a?iio?aeueii? anoie o oeii/ee?a ?
ae?a/aoie, coiiaeai? iniaeeainoyie ai?iiiaeueiiai noaoono caeaaeii a?ae
noao? o ioaa?oao?.

Aia?oa ?ic?iaeaiee niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo
aaaeei? oi?ie a?iio?aeueii? anoie o ae?oae oe??? a?eiai? a?oie ?
cai?iiiiiaai? e?eoa???, ye? aeicaieythoue ioe?ieoe aaaee?noue ia?aa?ao
caoai?thaaiiy ? iaa?oioiaaii i?ecia/eoe a?aeiia?aeio oa?ai?th.

?ic?iaeaia i?ia?aia o?eaaeiai e?eoaaiiy a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo c aeaoaeueiei aecia/aiiyi iieacaiue aei i?ecia/aiiy
??cieo a?oi i?ioecaiaeueieo i?aia?ao?a. Aia?oa iaa?oioiaai? i?aeoiaee
aei aeei?enoaiiy noa?i?aeii? oa?ai?? i?e a?iio?aeuei?e anoi? o ae?oae
ioaa?oaoiiai a?eo a ??ci? ia??iaee caoai?thaaiiy.

Aia?oa a Oe?a?i? i?iaiae?ciaai? ?acoeueoaoe ?iaioe “anoia-oeiee” aeey
ae?oae, oai?eo ia a?iio?aeueio anoio, oa ?o aaouee?a. Iieacaiee aieea
cai?iiiiiaaii? i?ia?aie e?eoaaiiy ? iaa/aiiy iaoe??io?a ia ia?aa?a
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

1. ?ic?iaeai? e?eoa??? aaaeeino? ia?aa?ao a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo.

2. Cai?iiiiiaaiee niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo
aaaeei? oi?ie caoai?thaaiiy o ae?oae oe??? a?eiai? a?oie.

3. ?ic?iaeaiee eiiieaeniee ieai caoiae?a ? i?aeoe/i? ?aeiiaiaeaoe?? aeey
e?eoaaiiy a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo, yeee aeeth/a?:

– i?ia?aio o?eaaei? iaaeeeaiaioicii? oa?ai??;

– aeai?eoi e?eoaaiiy i?enooio;

– iaa/aiiy iaoe??io?a ? ?o aaouee?a a “anoia-oeie?”;

– uiaeaiia iii?oi?ia niinoa?aaeaiiy ca ia?aa?aii oai?iae ? e?eoaaiiyi ca
aeiiiiiaith i?eoeioiao???.

4. Aecia/ai? iieacaiiy aei i?ecia/aiiy ??cieo a?oi i?ioecaiaeueieo
i?aia?ao?a (?ioae, oaeeaae, ei?oeeinoa?i?aee) aeey o?eaaei? aacenii?
oa?ai?? caoai?thaaiiy o ae?oae oe??? a?eiai? a?oie.

5. ?ic?iaeai? ?aeiiaiaeaoe?? aei i?ecia/aiiy noa?i?aeii? oa?ai??
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo a ??ci? ia??iaee
caoai?thaaiiy.

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a ?iaioo aeeoy/eo onoaiia i.
Eueaiaa e iaeano? (Euea?anueea i?nueea aeeoy/a ee?i?/ia e?ea?iy,
Euea?anueea i?nueea aeeoy/a eiinoeueoaoeaia iie?ee?i?ea, aeeoy/a
a?aeae?eaiiy Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, Euea?anueea
iaeania aeeoy/a ee?i?/ia e?ea?iy, ssai??anueea ?aee?ea?iy), Oe?a?inueei?
aeeoy/i? niaoe?ae?ciaaii? e?ea?i? “IOIAOAeEO” (i. Ee?a),
Aei?i?iiao?ianueei? iaeanii? aeeoy/i? ee?i?/ii? e?ea?i?, Caii??cueei?
i?nueei? aaaaoii?io?eueii? aeeoy/i? e?ea?i?, Oa?e?anueei? iaeanii?
aeeoy/i? ee?i?/ii? e?ea?i? ? 1 oa ?ioiieia?/iiai oeaio?o A?iieoeueeiai
i?ioeooaa?eoeueiciiai aeeniaina?o. Iaoa??aee ?iaioe aeei?enoiaothoueny a
iaa/aeueiiio i?ioean? ia eaoaae?ao iaae?ao??? Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo, Caii??cueei?, Oa?e?anueei? ? Aoeiaeinueei?
iaaee/ieo aeaaeai?e, eaoaae?? iaae?ao??? ? 1 Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaai? 2 ?ioi?iaoe?ei? eenoe ?
iaoiaee/i? ?aeiiaiaeaoe??, caoaa?aeaeai? IIC Oe?a?ie:

– Aao E.A. Iaoiaeeea i?aai?caoe?? ?iaioe “anoia-oeiee” aeey ae?oae,
oai?eo ia a?iio?aeueio anoio, oa ?o ?iaeei. ?ioi?iaoe?eiee eeno i?i
iiaiaaaaeaiiy a nenoai? ioi?iie caei?ia’y. – Aeione 1 ii i?iaeai?
“Iaae?ao??y”. ? 150–98. – 2 n.

– Aao E.A. Iaoiae aeei?enoaiiy i?aia?aoo “Oaeeaae” o e?eoaaii?
i?aee?oe?a, oai?eo ia a?iio?aeueio anoio. ?ioi?iaoe?eiee eeno i?i
iiaiaaaaeaiiy a nenoai? ioi?iie caei?ia’y. – Aeione 2 ii i?iaeai?
“Iaae?ao??y”. ? 151–97. – 2 n.

– Eaneoey I.?., Aao E.A. No/ania oaoiieia?y eiiieaeniiai e?eoaaiiy
a?iio?aeueii? anoie o ae?oae. Iaoiaee/i? ?aeiiaiaeaoe??. – Ee?a, 1998. –
19 n.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa ? iniaenoith i?aoeath
aaoi?a. Aaoi? i?iaiae?coaaea a?o/eciyio oa ca?oa?aeio e?oa?aoo?o c
i?iaeaie, ui aea/aeany, iniaenoi ieaioaaea iaoo ?iaioe oa caaaeaiiy
aeine?aeaeaiiy. An? aeine?aeaeaiiy aeeiiai? aaoi?ii naiino?eii.

Aaoi?ii iniaenoi noai?aia eiii’thoa?ia aaca aeaieo ?acoeueoao?a
ianoaaeaiiy ae?oae, iaienai? an? ?icae?ee aeena?oaoe?? oa noi?ioeueiaai?
aeniiaee.

?iaioa aeeiiaia ia eaoaae?? oaeoeueoaonueei? ? oieoaeueii? iaae?ao???
(caa?aeoaa/ eaoaae?e ae. i. i., i?ioani? Oea/aiei N.E.) Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?iai? Aeaieea Aaeeoeueeiai (?aeoi?
– ae. oa?i. i., i?ioani?, aeaaeai?e AIAO Oe?a?ie C?iaieianueeee A.N.)

I?aea??, ee?i?/ia oa ia?aee?i?/ia ianoaaeaiiy oai?eo, aea/aiiy
aoaeoeaiino? canoinoaaiiy ie?aieo iaaeeeaiaio?a (oaeeaae, ?iaaeyoe?ei?
noa?i?aee) oa ?ic?iaea i?ia?ai e?eoaaiiy anoie o i?aee?oe?a aeeiiai?
aaoi?ii naiino?eii. Ca ?i?oe?aoeaith ? aaciina?aaeiueith o/anoth aaoi?a
i?aai?ciaaia ?iaioa “anoia-oeiee” aeey ae?oae, oai?eo ia a?iio?aeueio
anoio, oa ?o aaouee?a. Aaoi? naiino?eii i?iaiae?coaaea aoaeoeai?noue
oaeiai iaa/aiiy.

Aaoi?ii iniaenoi i?iaaaeaiee aiae?c ?acoeueoao?a aeine?aeaeaiiy ia
ia?niiaeueiiio eiii’thoa?? ca aeiiiiiaith noaoenoe/iiai iaeaoa
“Statystica” (NOA), ia i?aenoaa? yeiai i?aeaioiaeai? aei ae?oeo an?
iaoeia? i?aoe?, iiiia?ao?y, i?aeaioiaeaia aei caoenoo aeena?oaoe?y ?
ai?iaaaeaeai? ?acoeueoaoe iaoeiaeo aeine?aeaeaiue o i?aeoeeo ioi?iie
caei?ia’y.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeena?oaoe??
aeiiia?aeaeeny ia IX I?aeia?iaeiiio eiia?an? ?ioiieia?a (San Francisco,
California, 1995); II Oe?a?inuee?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeooaeuei? i?iaeaie ee?i?/ii? ?ioiieia??” (Euea?a, 1996); I?aeia?iaei?e
eiioa?aioe?? ?ioiieia?a ? aea?aieia?a “Central and Eastern European
conference on astma, allergy and clinical immunology” (Lodz, Poland,
1996); can?aeaiiyo Oe?a?inueei? oeiee ioeueiiiieiaa (Ee?a, 1997);
I?aeia?iaei?e eiioa?aioe?? ioeueiiiieia?a ? ooec?ao??a (Paris, Franse,
1997); can?aeaiiyo aenia?oii? eii?n?? c ?ic?iaee ?aeiiaiaeaoe?e uiaei
ae?aaiinoeee ? oa?ai?? a?iio?aeueii? anoie, noai?aieo ca ?i?oe?aoeaith
IIC Oe?a?ie oa Anioe?aoe?? iaae?ao??a Oe?a?ie (Ee?a, 1998); V
I?aeia?iaeiiio neiiic?oi? e?ea??a-aea?aieia?a “Postempy w zakresie
diagnostyki i lenzenia chorob alergicznych” (Krakow, Polska, 1998); I
iaoe?iiaeueiiio eiia?an? c ee?i?/ii? ?ioiieia?? oa aea?aieia?? (Aeoooa,
1998); Ieaioi? anioe?aoe?? iaae?ao??a Oe?a?ie oa iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeuei? ieoaiiy aeeoy/i? ioeueiiiieia?? oa aea?aieia??
ia no/aniiio aoai? ?aoi?ioaaiiy ioi?iie caei?ia’y” (Ee?a, 1998); II
c’?cae? ooec?ao??a ? ioeueiiiieia?a Oe?a?ie (Ee?a, 1998); can?aeaii?
iaeaniiai iaoeiaiai oiaa?enoaa iaae?ao??a (Euea?a, 1996); eiioa?aioe?yo
iaae?ao??a, aea?aieia?a, ioeueiiiieia?a i. Eueaiaa oa iaeano? (Euea?a,
1996–1998 ??).

Ioae?eaoe??. Iniiai? iieiaeaiiy ?iaioe aeeeaaeai? o iiiia?ao??
“A?iio?aeueia anoia o i?aee?oe?a” (1998), a?ioo?? “sseui o Aaoi? aeeoeie
a?iio?aeueia anoia” (1998), 19 iaoeiaeo noaooyo, 6 oacao oa
?ioi?iaoe?eieo ioae?eaoe?yo.

Iaoa??aee aeena?oaoe?? aeei?enoai? a ?iaio? aenia?oii? eii?n??, yea ca
?i?oe?aoeaith IIC Oe?a?ie oa Anioe?aoe?? iaae?ao??a Oe?a?ie neeaea
“?aeiiaiaeaoe?? uiaei ae?aaiinoeee ? oa?ai?? a?iio?aeueii? anoie”
(1998).

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 290
noi??ieao ae?oeiaaiiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, aeeeaaeo iniiaieo iaoiaeee aeine?aeaeaiue, 6 ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/ii? /anoeie, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae, ui i?noeoue 385
ioae?eaoe?e (211 – a?o/eciyieo ? ?in?enueeeo aaoi??a, 174 – ?iicaiieo
aaoi??a) ia 49 noi??ieao. ?iaioa i?i?ethno?iaaia 32 oaaeeoeyie, 22
?enoieaie ? noaiaie, ui caeiathoue 35 noi??iie.

CI?NO AeENA?OAOe??

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Aeey aeeiiaiiy iinoaaeaieo caaaeaiue
ianoaaeaii 380 ae?oae, na?aae yeeo 280 – oai?? ia a?iio?aeueio anoio
(150 – ae?oe ioaa?oaoiiai a?eo a?ae 12 aei 15 ?ie?a, 130 – ae?oe a?ae 4
aei 11 ?ie?a) ? 100 – i?aee?oee eiio?ieueii? a?oie.

A?aeiia?aeii aei iinoaaeaieo iaoe ? caaaeaiue, aeine?aeaeaiiy
i?iaiaeeeeny o 9 a?oiao ae?oae (oaae. 1).

O ?iaio? ii?yae ?c caaaeueiiee?i?/ieie aeei?enoai? iaoiaee ioe?iee
?ioiieia?/ieo iieaciee?a ? ooieoe?iiaeueiiai noaio aiaeie?eiii? nenoaie.
I?iaiaeeeanue niaoeeo?/ia aea?aiae?aaiinoeea.

Caaaeueiiee?i?/i? iaoiaee aeeth/aee aeaoaeueia aea/aiiy aiaiiaco,
aaiaaeia?/ieo aeaieo, ia’?eoeaia ianoaaeaiiy, eaai?aoi?i? aeine?aeaeaiiy
(caaaeuei? aiae?ce e?ia? oa na/?, eii?ieia?y), aecia/aiiy ooieoe?e
i?aai?a ciai?oiueiai aeeoaiiy.

Oaaeeoey 1

Oa?aeoa?enoeea a?oi ianoaaeaiiy

O i?ioean? ia’?eoeaiiai ianoaaeaiiy, e??i o?aaeeoe?eiiai iinenoaiiiai
iaeyaeo, i?iaiaeeee eiiieaenio ioe?ieo o?ce/iiai ? noaoaaiai ?icaeoeo
ae?oae. Aio?iiiiao?e/i? iieacieee ioe?ithaaee ca noaiaea?oieie
oaaeeoeyie o?ce/iiai ?icaeoeo ae?oae Cao?aeiiai ?aa?iio Oe?a?ie
(Eanna?aaa I.I., I?eee ?.A., 1992). Nooi?iue noaoaaiai aeic??aaiiy
aecia/aee ia i?aenoaa? ioe?iee oi?ioaaiiy aoi?eiieo noaoaaeo iciae
ca?aeii iaoiaeeee E.I.Oeaiiai? ? ni?aaao. (1989).

Ooieoe?iiaeueiee noai nenoaie aeeoaiiy o oai?eo ioe?ithaaany ca
iieacieeaie ciai?oiueiai aeeoaiiy ca aeiiiiiaith ni??iiao?a (NNI) ?
iiaaiioaoiiao?a (IO-2). Iniaeeaa cia/aiiy iaaeaaaeiny aei??thaaiith
i?eoeoiiao?ii iaeneiaeueii? (i?eiai?) oaeaeeino? aeaeeoo (IOA), yea
i?yii ei?aeth? c aaee/eiith i?ina?oo aeeoaeueieo oeyo?a ? aeicaiey?
aecia/eoe nooi?iue a?iio?aeueii? iano?oeoe??.

Aeey aea/aiiy ooieoe?iiaeueiiai noaio aiaeie?eiii? nenoaie i?iaiaeeee
?aae?i?ioiiee aiae?c (??A) e?eueeino? ai?iii?a o ieaci? e?ia?,
aecia/aiiy 17eaoinoa?i?ae?a (17-EN) o na/? ? oeueo?acaoeiaa
aeine?aeaeaiiy ueoiaeaeii? caeice. Ca iaoiaeii ??A aea/aany ai?no oaeeo
ai?iii?a: oie?o?ii?i, etho?ii?i, i?ieaeoei, o?eeiaeoe?ii?i (O3),
oe?ienei (O4), oanoinoa?ii, ano?aae?ie, i?iaanoa?ii, ei?oecie, a oaeiae
aecia/aeeny oe?ieneica’ycoth/ee aeiaoe?i (OCA), oe?aio?iiiee aeiaoe?i
(OOA) ? aioeo?ea aei oe?aiaeiaoe?io. Aeey aecia/aiiy ai?iii?a
aeei?enoiaoaaeeny noaiaea?oi? iaai?e ?aaeoea?a. Oie?o?ii?i ? etho?ii?i
aecia/aee, aeei?enoiaoth/e iaa?? ?aaeoea?a o?aioeocnueei? o??ie
IMMUNOTECH, a ?io? – ca aeiiiiiaith ?aaeoea?a aini?ic?aooieiaiai
aeine?aeiiai ae?iaieoeoaa ?inoeoooo a?ii?aai?/ii? o?i?? Aeaaeai?? iaoe
?anioae?ee A?ea?onue (?AIO AI?A). Aea/ath/e ai?no ai?iiiaeueieo
iaoaaie?o?a o na/?, aecia/aee 17-EN (a iniiaiiio iaoaaie?oe noaoaaeo
ai?iii?a) oa 17-EAN (iaoaaie?oe aetheiei?oeei?ae?a) ca iaoiaeii
E.E.Norymberski (1955) a iiaeeo?eaoe?? TH.A.Eoea/eianueeiai ?
A.N.Ia?’?iei (1969). Aeine?aeaeaiiy i?iaiaeeeeny ia aacao iaeanii?
?aae?i?cioiiii? eaai?aoi??? e iaeaniiai aiaeie?eiieia?/iiai aeeniaina?o.

?ioiieia?/i? aeine?aeaeaiiy aeeth/aee: 1) aecia/aiiy noaio O- ?
A-ee?oeiii? nenoaie ?ioi?oaoo c aeei?enoaiiyi iaoiaeo ?icaoeiooai?aiiy;
2) aiae?c eiioeaio?aoe?? ne?iaaoeiaeo ?ioiiaeiaoe?i?a iaoiaeii
?aae?aeueii? ?ioiiaeeooc?? ca Mancini et al., 1965; 3) ioe?ieo ??aiy
ne?iaaoeiaiai IgE ca aeiiiiiaith oethi?anoeaioiiai aea?aini?aaioiiai
oanoo (FAST).

Aeey niaoeeo?/ii? aea?aiae?aaiinoeee aeei?enoiaoaaeeny nea?eo?eaoe?ei?
oe??i? oanoe ? niaoeeo?/ia ae?aaiinoeea aea?a?? in vitro. Inoaiiy
aeeth/aea: 1) aecia/aiiy niaoeeo?/ieo IgE oa IgG4 ca iaoiaeii FAST; 2)
?aaeoe?th niaoeeo?/iiai eaeeie?co ca i?e?iiiaeeo?eaoe??th C.I.O?aoyeaae/
oa ?i. (1980); 3) iaoiae “aeyoeiooai?aiiy”, ?ic?iaeaiee A.I.Iaiieiaith
oa ?i. (1981); 4) ?aaeoe?th oaeaeeino? in?aeaiiy a?eo?ioeeo?a c
iaaeeeaiaioaie (Iaeeiaeiaa A.A. oa ?i., 1985)

Noaoenoe/iee aiae?c ?acoeueoao?a aeine?aeaeaiiy cae?enithaaany ia
ia?niiaeueiiio eiii’thoa?? ca aeiiiiiaith noaoenoe/iiai iaeaoa
“Stat?st?na” (NOA).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. C iaoith aea/aiiy aieeao
??ciiiai?oieo oaeoi??a ia aeieeiaiiy ? ?icaeoie a?iio?aeueii? anoie
i?iaaaeaiee aeaoaeueiee aiae?c aiaiiaco o 150 ae?oae ioaa?oaoiiai a?eo c
aeei?enoaiiyi niaoe?aeueii? aieaoe-iieooaa/a. Aiae?c i?e/ei aeieeiaiiy
caoai?thaaiiy aeicaieea i?aeoaa?aeeoe i?ia?aeio ?ieue niaaeeiai?
noeeueiino? a aaiac? aeaii? iaoieia??. Aeiaaeee aoii?/ieo caoai?thaaiue
ca?a?no?iaai? o 76,7 % n?iae oai?eo ae?oae, ui cia/ii ia?aaeuo?
aiaeia?/iee iieaciee (15 %) o eiio?ieuei?e a?oi? caei?iaeo i?aee?oe?a.

Anoaiiaeaii, ui ?aae?caoe?? niaaeeiai? noeeueiino? ni?eythoue: oe?aeeea?
aioaiaoaeuei? oaeoi?e (ia?aoe?iiaeueia oa?/oaaiiy aaa?oii? – 73,3 %
aeiaaee?a, aaeeaaiiy e?e?a – 19,3 %, aanoice aaa?oieo –34,5 %,
i?ioan?ei? (16,7 %) ? iiaooia? (27,3 %) eiioaeoe c o?i?/ieie oa
e?ea?nueeeie ?a/iaeiaie); ia?eiaoaeueia aioeaoaeiiao?y (6,7 %); /ano?
aino?? ?ani??aoi?i? a??oni? ?ioaeoe?? (40,0 %).

Aaciina?aaeiueith i?e/eiith ?icaeoeo ia?oeo i?enooi?a a?iio?aeueii?
anoie a ianoaaeaieo ae?oae iae/ano?oa aoee aea?aaie aeiiaoiueiai ieeo ?
ieeeo ?ineei, ??aeoa aea?aaie eioa, i??’y iiaeooee oiui.

Iiaoi?i? i?enooie caoai?thaaiiy o ae?oae ioaa?oaoiiai a?eo iae/ano?oa
i?iaieoaaeeny oaeeie o?eaa?ieie oaeoi?aie: aea?aaie (70,0 %), aino??
?ani??aoi?i? a??oni? ?ioaeoe?? (64,0 %), iaaei??i? o?ce/i? (66,6 %) oa
aiioe?ei? (10,0 %) iaaaioaaeaiiy, iaoaioaeoi?e (50,0 %), ai?iiiaeueiee
aeenaaeain o ae?a/aoie o ia?aaeiaino?oaeueiiio ia??iae? (85,9 %).
Aeyaeaiiy o?eaa?ieo oaeoi??a aeicaiey? onoiooe aai oi/a a ciaioeoe ?o
aieea ia i?aai?ci, ui ni?ey? iieaaoaiith ia?aa?ao ? iie?ioaiith i?iaiico
caoai?thaaiiy.

Aeey ae?aaiinoeee a?iio?aeueii? anoie o i?aee?oe?a aeei?enoiaoaaany
aeaniee ae?aaiinoe/iee aeai?eoi (?en. 1). Iniiaith aeey ae?aaiico aoee
oeiiaee aiaiiac, ee?i?ea caoai?thaaiiy, iieacieee ooieoe?e i?aai?a
ciai?oiueiai aeeoaiiy. I?iaiaeeeiny niaoeeo?/ia aea?aieia?/ia
oanooaaiiy. Aiae?c eiai ?acoeueoao?a aeicaieea aecia/eoe no?oeoo?o
nainea?e?caoe?? o ae?oae ioaa?oaoiiai a?eo. Na?aae 98 ianoaaeaieo
i?aee?oe?a iae/ano?oa ?a?no?oaaeany aeniea nainea?e?caoe?y aei aea?aai?a
aeiiaoiueiai (73,4 % aeiaaee?a) /e a?ae?ioa/iiai (57,1 %) ieeo, oa?/iaeo
i?iaeoeo?a (53,1 %). ??aeoa niinoa??aaeany i?aeaeuaia nainea?e?caoe?y
aei ieeeiaeo aea?aai?a (51,0 % oai?eo) ? i??’y iiaeooee (36,7 % oai?eo).
Aenieee ??aaiue nainea?e?caoe?? aei ai?aea?iaeueieo aea?aai?a oaa?ei
aeyaeaiee o 35,7 % iaoe??io?a.

A?iio?aeueia anoia o i?aee?oe?a aeoaea ??aeei aoea ?cieueiaaiei
caoai?thaaiiyi. Ia?aaaaeii o oaeeo oai?eo niinoa??aaeany noiooiy
iaoieia?y, yea nooo?ai aieeaaea ia ia?aa?a iniiaiiai caoai?thaaiiy
(aea?a?/ia ?eiineioniiao?y – 34,7 % oai?eo, a?ia?o?io?y ieaaeaeee?a –
42,0 %, iaoieia?y aaiaoia?e?a?ii? nenoaie – 53,3 %, o?ii?/iee
aano?iaeoiaeai?o – 28,0 %).

Oaaeeoey 2

E?eoa??? aaaeeino? a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo

Aea/aiiy iniaeeainoae ee?i?/iiai ia?aa?ao a?iio?aeueii? anoie aeyaeei,
ui o ae?oae ioaa?oaoiiai a?eo ia?aaaaeaea na?aaeiueiaaaeea oi?ia
caoai?thaaiiy (44,7 % aeiaaee?a), a aaaeea ? eaaea ae?aaiinooaaeeny c
i?eaeecii iaeiaeiaith /anoioith (a?aeiia?aeii 26,6 % ? 28,7 %). Aiae?c
oa?aeoa?o ia?aa?ao a?iio?aeueii? anoie o 3 a?eiaeo a?oiao ae?oae (? –
150 i?aee?oe?a, ?? – 50 ae?oae a?ae 4 aei 8 ?ie?a, ??? – 80 ae?oae
i?ciueiai i?aioaa?oaoiiai a?eo) iieacaa, ui o ae?oae i?ciueiai
i?aioaa?oaoiiai a?eo aaaeeee ia?aa?a a?iio?aeueii? anoie ?a?no?o?oueny
iae??aeoa. Aiaeii/an o aeaio ?ioeo a?oiao aeine?aeaeaiiy oey oi?ia
caoai?thaaiiy cono??/a?oueny c iaeaea iaeiaeiaith /anoioith (?en. 2).

?en. 2. Aiae?c aaaeeino? ia?aa?ao a?iio?aeueii? anoie o ae?oae ??cieo
a?eiaeo a?oi

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui ioa?oaoiee a?e iiaeia aaaaeaoe
oaeoi?ii ?eceeo ?icaeoeo anoiaoe/iiai noaio, ine?eueee c 89 ae?oa, ye?
iinooieee a ee?i?eo a anoiaoe/iiio noaoon?, 44 (49,0 %) – ae?oe oe???
a?eiai? a?oie.

Iao? aeine?aeaeaiiy aeiaaee, ui anoia a ioaa?oaoiiio a?oe? ci?ith? na?e
ia?aa?a. O 49,1 % ae?a/aoie a?i iia??oo?oueny, aiaeii/an o a?eueoino?
oeii/ee?a (84,2 %) niinoa??aa?oueny ee?i?/ia iie?ioaiiy. Iia??oaiith
ia?aa?ao oai?iae ni?ey? c?inoaiiy o?eaa?iiai iaaaioaaeaiiy ia i?aai?ci
i?aee?oe?a, a naia: aeniea /anoioa A?A?, oa?aeoa?ia aeey i?aee?oe?a
aiioe?eia eaa?euei?noue, ia?aici?noue. I?eoaiaii? ioaa?oaoiiio a?eia?
ai?iiiaeuei? c?ooaiiy a i?aai?ci? i?ecaiaeyoue aei oiai, ui oeii/eee ?
ae?a/aoea ii-??ciiio ?aaaothoue ia oaea o?eaa?ia iaaaioaaeaiiy.

A ia??iae noaoaaiai aeic??aaiiy oa noaiiaeaiiy ?ai?iaeoeoeaii? ooieoe??
i?aai?cio aaeeea cia/aiiy iaaoaathoue noaoaa? ai?iiie. O oeueiio a?oe?
i?ia?aneaii i?aeaeuo?oueny aiiaaeio?iiia ooieoe?y a?iio?ca ? c?inoa?
aeoeai?noue aiiaae.

Ioe?ithth/e ooieoe?iiaeueio aeoeai?noue ?ai?iaeoeoeaii? nenoaie o 50-oe
ae?a/aoie ioaa?oaoiiai a?eo, ie i?iaiaeeee aeine?aeaeaiiy a aeaio
a?oiao: ia?oo neeaee 12 iaoe??ioie, o yeeo iaino?oaoe?? ua ia ii/aeeny,
a ae?oao – 38 ae?a/ao c iayaiei iaino?oaeueiei oeeeeii. O 12-oe
ae?a/aoie ae?oai? a?oie iaino?oaeueiee oeeee aoa ?aaoey?iee, o?eaae?noth
27–30 aei?a. O ?aooe (26) iaoe??ioie a?aecia/aany ia?aaoey?iee
iaino?oaeueiee oeeee, i?e/iio eiai noaiiaeaiiy caoyaoaaeiny, ii??aiyii
c? caei?iaeie ?iaanieoeyie. Ai?no aiiaaeio?iiieo ? noaoaaeo ai?iii?a, a
oaeiae i?ieaeoeio a e?ia? ianoaaeaieo ae?a/aoie ioaa?oaoiiai a?eo,
oai?eo ia a?iio?aeueio anoio, iaaaaeaii a oaae. 3.

Oaaeeoey 3

Eiioeaio?aoe?y aiiaaeio?iiieo, noaoaaeo ai?iii?a ? i?ieaeoeio a e?ia?
ae?a/aoie ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio

I?ei?oea. * ?  0,05). A?aeiii, ui i?ae aieeaii oanoinoa?iio oi?iothoueny iniiai?
aoi?eii? noaoaa? iciaee. Oeii/eee, a yeeo ae?aaiinoiaaii aaaeeee ia?aa?a
a?iio?aeueii? anoie, a?aenoaaaee o noaoaaiio aeic??aaii?. ??aaiue
oanoinoa?iio o ieo aoa aeinoia??ii ieae/ei, i?ae o caei?iaeo ?iaaniee?a
(a?aeiia?aeii (2,0±0,82) ia/e ? (2,9±0,91) ia/e, p 

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