24

?INOEOOO OOEC?AO??? ? IOEUeIIIIEIA???i. O.A.ssIIANUeEIAIAEAAeAI??
IAAeE*IEO IAOE OE?A?IE

AAO Eany Aanee?aia

OAeE:616.248-053.6–092-08

A?IIO?AEUeIA ANOIA O Ae?OAE IOAA?OAOIIAI A?EO: INIAEEAINO?
IAOIAAIACO,IA?AA?AO ? E?EOAAIIss

14.01.27. – ioeueiiiieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyaeieoi?a iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
Aeaieea Aaeeoeueeiai IIC Oe?a?ie.

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, i?ioani? EANEOess Ieueaa ?ea??ii?aia, Ee?anueea
iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,
caa?aeoaa/ eaoaae?e iaae?ao??? ? 1.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? OOAA Iaii?ea Ieoaee?aia, Ee?anueea
iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,
i?ioani? eaoaae?e oa?ai?? oa ?aaiaoieia??;

aeieoi? iaaee/ieo iaoe, i?ioani? IA?OeAAA Oaoyia Ieaen??aia,
Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie, caa?aeoaa/
eaoaae?e oaeoeueoaonueei? oa?ai?? oa aiaeie?eiieia??;

aeieoi? iaaee/ieo iaoe IICAEAANUeEEE Aiaoie?e Oaiaein?eiae/, ?inoeooo
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, caa?aeoaa/
a?aeae?eaiiy caoai?thaaiue i?aai?a aeeoaiiy.

I?ia?aeia onoaiiaa:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey (i. Ee?a),
eaoaae?a iaae?ao??? ? 4.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “__01____” ___11 1999 ?ieo i
_14__ aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.552.01
i?e ?inoeooo? ooec?ao??? ? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII
Oe?a?ie ca aae?anith: 252110, i. Ee?a, INI-680, oca?c I?ioan?a ss?, 7.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?inoeoooo ooec?ao???
? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie ca aae?anith (252110,
i. Ee?a, oca?c I?ioan?a ss?, 7).

Aaoi?aoa?ao ?ic?neaiee “ _30_ ” ____09____ 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee AE.A.Aaaioe?aa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia a?iio?aeueii? anoie iei? noi?oue
iaaecae/aeii aino?i. *anoioa oeueiai caoai?thaaiiy c ?ieo a ??e
iaooeeueii c?inoa?. Ca ?acoeueoaoaie iiioeyoe?eieo ai?aeai?ieia?/ieo
aeine?aeaeaiue, iioe?ai?noue a?iio?aeueii? anoie a a?eueoino? e?a?i
na?oo eieeaa?oueny a na?aaeiueiio ia ??ai? 3-7 % (Oauaiei TH.?., 1997).

Iniaeeai o?eaiaeiith ? neooaoe?y c aeeoy/ith anoiith, iioe?ai?noue yei?
a ??cieo iiioeyoe?yo eieeaa?oueny iaeaea a?ae 0 % aei 30 %. *anoioa
oeueiai caoai?thaaiiy na?aae ae?oae O?aioe?? noaiiaeoue 7 %, Aiae?? –
11 %, NOA – 13 %, Aano?ae?? – 7-10 %, Iiai? Caeaiae?? – 8 %, ??eaiae?? –
35 %, ?in?? – 10 % (Gergen P.J., et al., 1988; Pararajasingam C.D. et
al., 1992; Eaaaiia N.TH., 1995). Ia aeaeue, nueiaiaei? i?aeoe/ii
a?aenooi? aeinoia??i? aeai? noiniaii /anoioe a?iio?aeueii? anoie na?aae
ae?oae Oe?a?ie. A?eueo?noue aeine?aeiee?a aea/aee iioe?ai?noue oeueiai
caoai?thaaiiy ia i?aenoaa? caa?oaiue ca iaaee/iith aeiiiiiaith, ui ca
ia’?eoeaieo oiia ia a?aeia?aaea? ni?aaaeith neooaoe?th ? cia/ii caieaeo?
iieacieee (?e?iiaa ?.?., 1995; Oauaiei TH.?., 1997). ? eeoa inoaii?i
/anii iioae?eiaai? ia?o? ?acoeueoaoe na?eicieo oe?eani?yiiaaieo
ee?i?ei-ai?aeai?ieia?/ieo aeine?aeaeaiue, ye? a 2,5-3 ?ace ia?aaeuothoue
iieacieee io?oe?eii? noaoenoeee. Oae? ??ci? i?aeoiaee aei aea/aiiy
ai?aeai?ieia?? anoie, a oaeiae ?yae ?ioeo ia’?eoeaieo oaeoi??a
iiyniththoue eieeaaiiy /anoioe oeueiai caoai?thaaiiy na?aae ae?oae
Oe?a?ie a?ae 0,9 % aei 6,7 % (o na?aaeiueiio – 2,8 %) (Eaneoey I.?.,
1996).

I?iaeiaaeo? c?inoaoe /anoioa aaaeeeo oi?i a?iio?aeueii? anoie, ia?anoaee
aooe aeiyoeii aeiaaeee nia?o? ae?oae, ni?iaieiaai? oe??th iaaeoaith
(Eaaaiia N.TH., 1993; Caaieioneeo O.A. e ae?., 1997)

Aaeeea e?euee?noue ??ciiiai?oieo iaaee/ieo i?aai?caoe?e o anueiio na?o?
i?aoeth? iaae ?ica’ycaiiyi i?iaeai a?iio?aeueii? anoie. ?iaioa oey
eii?aeeio?oueny I?aeia?iaeiith a?oiith niaoe?ae?no?a – aenia?o?a c
i?iaeai anoie, yea iaiaaa?oueny ?ic?iaeoe ?aeei? aeey an?o e?a?i
i?aeoiaee aei ae?aaiinoeee ? e?eoaaiiy oeueiai aaaeeiai caoai?thaaiiy.

Aea, iacaaaeath/e ia oae? aeiaaeuei? ? a?oioiai? aeine?aeaeaiiy, anoia ?
iei? caeeoa?oueny iaoieia??th c aaaaoueia iac’yniaaieie ieoaiiyie.
Cie?aia, iaaeinoaoiuei aea/aieie ? iniaeeaino? ia?aa?ao oeueiai
caoai?thaaiiy o ae?oae ioaa?oaoiiai a?eo. A?aeiii, ui oeae ia??iae
aeeoeinoaa iaeaaeeoue aei e?eoe/ieo ia??iae?a iioiaaiaco ethaeeie, eiee
i?aai?ci anooia? o /an noaoaaiai aeic??aaiiy ? iieiy?oueny ia?aae iiaei
o?c?ieia?/iei no?eaeii e?euee?niiai ? ye?niiai ?inoo oa ??cei?
ia?aaoaeiae ooieoe?e iaeaea an?o i?aai?a ? nenoai (Ia?e?i E.A. oa ?i.,
1996).

?niothoue aeai? i?i oa, ui o 2/3 ae?oae anoia a ioaa?oaoiiio ia??iae?
ci?ith? na?e ia?aa?a (?eoi?ia N.E. oa ?i., 1986; ?eue?i A.A. oa ?i.,
1986; Iaee?ia E.A., 1993; Balfour-Lunn L., 1985; Gern J.E. et al., 1995;
Kintner E., 1997). Iaeiae, oe? ?iaioe iiiaeeiie? ? ia aeathoue
oe?e?niiai oyaeaiiy i?i i?e/eie, ye? coiiaeththoue ci?io ee?i?ee
a?iio?aeueii? anoie a i?aee?oeiaiio a?oe?. Aeeneon?eieie caeeoathoueny
ieoaiiy no?aoaa?? e?eoaaiiy. Iniaeeai oea noino?oueny i?iaeai
ai?iiiaeueii? oa?ai?? ? ?? aieeao ia ?ai?iaeoeoeaio ooieoe?th o
iaeaooiueiio.

Aeacaia aeua neooaoe?y aecia/eea aeooaeuei?noue ? iaoo iaoiai
aeine?aeaeaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioa aeeiiaia o Euea?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? a
iaaeao iaoeiai? oaiaoeee eaoaae?e iaae?ao??? ? 1 Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe “Ee?i?ei-iaoiaaiaoe/i? aa??aioe ?
aoaeoeai?noue oa?ai?? ?ani??aoi?ieo aea?aic?a o a?eiaiio aniaeo?”, ?
aea?ae?a?no?aoe?? OA-01013633?, ia?a?a?no?iaaia 12/3-1241 a?ae 5.10.92.

Iaoa aeine?aeaeaiiy. ?ic?iaeoe i?ia?aie e?eoaaiiy a?iio?aeueii? anoie o
ae?oae ioaa?oaoiiai a?eo ia i?aenoaa? eiiieaeniiai aea/aiiy iniaeeainoae
iaoiaaiaco, ee?i?ee oa ia?aa?ao caoai?thaaiiy.

A?aeiia?aeii aei iinoaaeaii? iaoe aecia/ai? oae? caaaeaiiy
aeine?aeaeaiiy:

1. Aea/eoe i?e/eie aeieeiaiiy ? ?icaeoeo a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo.

2. I?iaiae?coaaoe ee?i?/i? iniaeeaino? ia?aa?ao a?iio?aeueii? anoie o
ae?oae oe??? a?eiai? a?oie.

3. I?iaanoe ioe?ieo ai?iiiaeueiiai, ?ioiieia?/iiai e aea?aieia?/iiai
noaoono o oe?e a?oi? ae?oae.

4. I?iaiae?coaaoe aieea ai?iiiaeueiiai aeenaaeaino ia ia?aa?a
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo.

5. ?ic?iaeoe ? ai?iaaaeeoe o i?aeoeeo ae?aaiinoe/i? e?eoa??? aaaeeino?
ia?aa?ao a?iio?aeueii? anoie o ae?oae oe??? a?eiai? a?oie.

6. ?ic?iaeoe niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo aaaeei?
oi?ie a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo.

7. Ia i?aenoaa? io?eiaieo aeaieo ?ic?iaeoe eiiieaeniee ieai caoiae?a ?
i?aeoe/i? ?aeiiaiaeaoe?? aeey e?eoaaiiy a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo.

8. Aea/eoe aeeiai?eo caoai?thaaiiy ia oii? aeei?enoaiiy cai?iiiiiaaieo
i?ia?ai e?eoaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a

Aia?oa a Oe?a?i? i?iaaaeaia eiiieaenia aea/aiiy iniaeeainoae ia?aa?ao
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo. Aecia/ai? i?e/eie e
iniiai? iaoiaaiaoe/i? eaiee, ui i?ecaiaeyoue aei ci?ie ee?i?/iiai
ia?aa?ao oeueiai caoai?thaaiiy a ia??iae noaoaaiai aeic??aaiiy. Aia?oa
iieacai? a?aei?iiino? ee?i?ee a?iio?aeueii? anoie o oeii/ee?a ?
ae?a/aoie, coiiaeai? iniaeeainoyie ai?iiiaeueiiai noaoono caeaaeii a?ae
noao? o ioaa?oao?.

Aia?oa ?ic?iaeaiee niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo
aaaeei? oi?ie a?iio?aeueii? anoie o ae?oae oe??? a?eiai? a?oie ?
cai?iiiiiaai? e?eoa???, ye? aeicaieythoue ioe?ieoe aaaee?noue ia?aa?ao
caoai?thaaiiy ? iaa?oioiaaii i?ecia/eoe a?aeiia?aeio oa?ai?th.

?ic?iaeaia i?ia?aia o?eaaeiai e?eoaaiiy a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo c aeaoaeueiei aecia/aiiyi iieacaiue aei i?ecia/aiiy
??cieo a?oi i?ioecaiaeueieo i?aia?ao?a. Aia?oa iaa?oioiaai? i?aeoiaee
aei aeei?enoaiiy noa?i?aeii? oa?ai?? i?e a?iio?aeuei?e anoi? o ae?oae
ioaa?oaoiiai a?eo a ??ci? ia??iaee caoai?thaaiiy.

Aia?oa a Oe?a?i? i?iaiae?ciaai? ?acoeueoaoe ?iaioe “anoia-oeiee” aeey
ae?oae, oai?eo ia a?iio?aeueio anoio, oa ?o aaouee?a. Iieacaiee aieea
cai?iiiiiaaii? i?ia?aie e?eoaaiiy ? iaa/aiiy iaoe??io?a ia ia?aa?a
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a

1. ?ic?iaeai? e?eoa??? aaaeeino? ia?aa?ao a?iio?aeueii? anoie o ae?oae
ioaa?oaoiiai a?eo.

2. Cai?iiiiiaaiee niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo
aaaeei? oi?ie caoai?thaaiiy o ae?oae oe??? a?eiai? a?oie.

3. ?ic?iaeaiee eiiieaeniee ieai caoiae?a ? i?aeoe/i? ?aeiiaiaeaoe?? aeey
e?eoaaiiy a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo, yeee aeeth/a?:

— i?ia?aio o?eaaei? iaaeeeaiaioicii? oa?ai??;

— aeai?eoi e?eoaaiiy i?enooio;

— iaa/aiiy iaoe??io?a ? ?o aaouee?a a «anoia-oeie?»;

— uiaeaiia iii?oi?ia niinoa?aaeaiiy ca ia?aa?aii oai?iae ? e?eoaaiiyi ca
aeiiiiiaith i?eoeioiao???.

4. Aecia/ai? iieacaiiy aei i?ecia/aiiy ??cieo a?oi i?ioecaiaeueieo
i?aia?ao?a (?ioae, oaeeaae, ei?oeeinoa?i?aee) aeey o?eaaei? aacenii?
oa?ai?? caoai?thaaiiy o ae?oae oe??? a?eiai? a?oie.

5. ?ic?iaeai? ?aeiiaiaeaoe?? aei i?ecia/aiiy noa?i?aeii? oa?ai??
a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo a ??ci? ia??iaee
caoai?thaaiiy.

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a ?iaioo aeeoy/eo onoaiia i.
Eueaiaa e iaeano? (Euea?anueea i?nueea aeeoy/a ee?i?/ia e?ea?iy,
Euea?anueea i?nueea aeeoy/a eiinoeueoaoeaia iie?ee?i?ea, aeeoy/a
a?aeae?eaiiy Euea?anueei? iaeanii? ee?i?/ii? e?ea?i?, Euea?anueea
iaeania aeeoy/a ee?i?/ia e?ea?iy, ssai??anueea ?aee?ea?iy), Oe?a?inueei?
aeeoy/i? niaoe?ae?ciaaii? e?ea?i? “IOIAOAeEO” (i. Ee?a),
Aei?i?iiao?ianueei? iaeanii? aeeoy/i? ee?i?/ii? e?ea?i?, Caii??cueei?
i?nueei? aaaaoii?io?eueii? aeeoy/i? e?ea?i?, Oa?e?anueei? iaeanii?
aeeoy/i? ee?i?/ii? e?ea?i? ? 1 oa ?ioiieia?/iiai oeaio?o A?iieoeueeiai
i?ioeooaa?eoeueiciiai aeeniaina?o. Iaoa??aee ?iaioe aeei?enoiaothoueny a
iaa/aeueiiio i?ioean? ia eaoaae?ao iaae?ao??? Euea?anueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo, Caii??cueei?, Oa?e?anueei? ? Aoeiaeinueei?
iaaee/ieo aeaaeai?e, eaoaae?? iaae?ao??? ? 1 Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe.

Ca iaoa??aeaie aeena?oaoe?? iioae?eiaai? 2 ?ioi?iaoe?ei? eenoe ?
iaoiaee/i? ?aeiiaiaeaoe??, caoaa?aeaeai? IIC Oe?a?ie:

— Aao E.A. Iaoiaeeea i?aai?caoe?? ?iaioe “anoia-oeiee” aeey ae?oae,
oai?eo ia a?iio?aeueio anoio, oa ?o ?iaeei. ?ioi?iaoe?eiee eeno i?i
iiaiaaaaeaiiy a nenoai? ioi?iie caei?ia’y. – Aeione 1 ii i?iaeai?
“Iaae?ao??y”. ? 150–98. – 2 n.

— Aao E.A. Iaoiae aeei?enoaiiy i?aia?aoo “Oaeeaae” o e?eoaaii?
i?aee?oe?a, oai?eo ia a?iio?aeueio anoio. ?ioi?iaoe?eiee eeno i?i
iiaiaaaaeaiiy a nenoai? ioi?iie caei?ia’y. – Aeione 2 ii i?iaeai?
“Iaae?ao??y”. ? 151–97. – 2 n.

— Eaneoey I.?., Aao E.A. No/ania oaoiieia?y eiiieaeniiai e?eoaaiiy
a?iio?aeueii? anoie o ae?oae. Iaoiaee/i? ?aeiiaiaeaoe??. – Ee?a, 1998. –
19 n.

Iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa ? iniaenoith i?aoeath
aaoi?a. Aaoi? i?iaiae?coaaea a?o/eciyio oa ca?oa?aeio e?oa?aoo?o c
i?iaeaie, ui aea/aeany, iniaenoi ieaioaaea iaoo ?iaioe oa caaaeaiiy
aeine?aeaeaiiy. An? aeine?aeaeaiiy aeeiiai? aaoi?ii naiino?eii.

Aaoi?ii iniaenoi noai?aia eiii’thoa?ia aaca aeaieo ?acoeueoao?a
ianoaaeaiiy ae?oae, iaienai? an? ?icae?ee aeena?oaoe?? oa noi?ioeueiaai?
aeniiaee.

?iaioa aeeiiaia ia eaoaae?? oaeoeueoaonueei? ? oieoaeueii? iaae?ao???
(caa?aeoaa/ eaoaae?e ae. i. i., i?ioani? Oea/aiei N.E.) Euea?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?iai? Aeaieea Aaeeoeueeiai (?aeoi?
– ae. oa?i. i., i?ioani?, aeaaeai?e AIAO Oe?a?ie C?iaieianueeee A.N.)

I?aea??, ee?i?/ia oa ia?aee?i?/ia ianoaaeaiiy oai?eo, aea/aiiy
aoaeoeaiino? canoinoaaiiy ie?aieo iaaeeeaiaio?a (oaeeaae, ?iaaeyoe?ei?
noa?i?aee) oa ?ic?iaea i?ia?ai e?eoaaiiy anoie o i?aee?oe?a aeeiiai?
aaoi?ii naiino?eii. Ca ?i?oe?aoeaith ? aaciina?aaeiueith o/anoth aaoi?a
i?aai?ciaaia ?iaioa “anoia-oeiee” aeey ae?oae, oai?eo ia a?iio?aeueio
anoio, oa ?o aaouee?a. Aaoi? naiino?eii i?iaiae?coaaea aoaeoeai?noue
oaeiai iaa/aiiy.

Aaoi?ii iniaenoi i?iaaaeaiee aiae?c ?acoeueoao?a aeine?aeaeaiiy ia
ia?niiaeueiiio eiii’thoa?? ca aeiiiiiaith noaoenoe/iiai iaeaoa
“Statystica” (NOA), ia i?aenoaa? yeiai i?aeaioiaeai? aei ae?oeo an?
iaoeia? i?aoe?, iiiia?ao?y, i?aeaioiaeaia aei caoenoo aeena?oaoe?y ?
ai?iaaaeaeai? ?acoeueoaoe iaoeiaeo aeine?aeaeaiue o i?aeoeeo ioi?iie
caei?ia’y.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeena?oaoe??
aeiiia?aeaeeny ia IX I?aeia?iaeiiio eiia?an? ?ioiieia?a (San Francisco,
California, 1995); II Oe?a?inuee?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeooaeuei? i?iaeaie ee?i?/ii? ?ioiieia??” (Euea?a, 1996); I?aeia?iaei?e
eiioa?aioe?? ?ioiieia?a ? aea?aieia?a “Central and Eastern European
conference on astma, allergy and clinical immunology” (Lodz, Poland,
1996); can?aeaiiyo Oe?a?inueei? oeiee ioeueiiiieiaa (Ee?a, 1997);
I?aeia?iaei?e eiioa?aioe?? ioeueiiiieia?a ? ooec?ao??a (Paris, Franse,
1997); can?aeaiiyo aenia?oii? eii?n?? c ?ic?iaee ?aeiiaiaeaoe?e uiaei
ae?aaiinoeee ? oa?ai?? a?iio?aeueii? anoie, noai?aieo ca ?i?oe?aoeaith
IIC Oe?a?ie oa Anioe?aoe?? iaae?ao??a Oe?a?ie (Ee?a, 1998); V
I?aeia?iaeiiio neiiic?oi? e?ea??a-aea?aieia?a “Postempy w zakresie
diagnostyki i lenzenia chorob alergicznych” (Krakow, Polska, 1998); I
iaoe?iiaeueiiio eiia?an? c ee?i?/ii? ?ioiieia?? oa aea?aieia?? (Aeoooa,
1998); Ieaioi? anioe?aoe?? iaae?ao??a Oe?a?ie oa iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Aeooaeuei? ieoaiiy aeeoy/i? ioeueiiiieia?? oa aea?aieia??
ia no/aniiio aoai? ?aoi?ioaaiiy ioi?iie caei?ia’y» (Ee?a, 1998); II
c’?cae? ooec?ao??a ? ioeueiiiieia?a Oe?a?ie (Ee?a, 1998); can?aeaii?
iaeaniiai iaoeiaiai oiaa?enoaa iaae?ao??a (Euea?a, 1996); eiioa?aioe?yo
iaae?ao??a, aea?aieia?a, ioeueiiiieia?a i. Eueaiaa oa iaeano? (Euea?a,
1996–1998 ??).

Ioae?eaoe??. Iniiai? iieiaeaiiy ?iaioe aeeeaaeai? o iiiia?ao??
«A?iio?aeueia anoia o i?aee?oe?a» (1998), a?ioo?? “sseui o Aaoi? aeeoeie
a?iio?aeueia anoia” (1998), 19 iaoeiaeo noaooyo, 6 oacao oa
?ioi?iaoe?eieo ioae?eaoe?yo.

Iaoa??aee aeena?oaoe?? aeei?enoai? a ?iaio? aenia?oii? eii?n??, yea ca
?i?oe?aoeaith IIC Oe?a?ie oa Anioe?aoe?? iaae?ao??a Oe?a?ie neeaea
“?aeiiaiaeaoe?? uiaei ae?aaiinoeee ? oa?ai?? a?iio?aeueii? anoie”
(1998).

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 290
noi??ieao ae?oeiaaiiai oaenoo ? neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, aeeeaaeo iniiaieo iaoiaeee aeine?aeaeaiue, 6 ?icae?e?a
aeanieo aeine?aeaeaiue, caeeth/ii? /anoeie, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae, ui i?noeoue 385
ioae?eaoe?e (211 – a?o/eciyieo ? ?in?enueeeo aaoi??a, 174 – ?iicaiieo
aaoi??a) ia 49 noi??ieao. ?iaioa i?i?ethno?iaaia 32 oaaeeoeyie, 22
?enoieaie ? noaiaie, ui caeiathoue 35 noi??iie.

CI?NO AeENA?OAOe??

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Aeey aeeiiaiiy iinoaaeaieo caaaeaiue
ianoaaeaii 380 ae?oae, na?aae yeeo 280 – oai?? ia a?iio?aeueio anoio
(150 – ae?oe ioaa?oaoiiai a?eo a?ae 12 aei 15 ?ie?a, 130 – ae?oe a?ae 4
aei 11 ?ie?a) ? 100 – i?aee?oee eiio?ieueii? a?oie.

A?aeiia?aeii aei iinoaaeaieo iaoe ? caaaeaiue, aeine?aeaeaiiy
i?iaiaeeeeny o 9 a?oiao ae?oae (oaae. 1).

O ?iaio? ii?yae ?c caaaeueiiee?i?/ieie aeei?enoai? iaoiaee ioe?iee
?ioiieia?/ieo iieaciee?a ? ooieoe?iiaeueiiai noaio aiaeie?eiii? nenoaie.
I?iaiaeeeanue niaoeeo?/ia aea?aiae?aaiinoeea.

Caaaeueiiee?i?/i? iaoiaee aeeth/aee aeaoaeueia aea/aiiy aiaiiaco,
aaiaaeia?/ieo aeaieo, ia’?eoeaia ianoaaeaiiy, eaai?aoi?i? aeine?aeaeaiiy
(caaaeuei? aiae?ce e?ia? oa na/?, eii?ieia?y), aecia/aiiy ooieoe?e
i?aai?a ciai?oiueiai aeeoaiiy.

Oaaeeoey 1

Oa?aeoa?enoeea a?oi ianoaaeaiiy

O i?ioean? ia’?eoeaiiai ianoaaeaiiy, e??i o?aaeeoe?eiiai iinenoaiiiai
iaeyaeo, i?iaiaeeee eiiieaenio ioe?ieo o?ce/iiai ? noaoaaiai ?icaeoeo
ae?oae. Aio?iiiiao?e/i? iieacieee ioe?ithaaee ca noaiaea?oieie
oaaeeoeyie o?ce/iiai ?icaeoeo ae?oae Cao?aeiiai ?aa?iio Oe?a?ie
(Eanna?aaa I.I., I?eee ?.A., 1992). Nooi?iue noaoaaiai aeic??aaiiy
aecia/aee ia i?aenoaa? ioe?iee oi?ioaaiiy aoi?eiieo noaoaaeo iciae
ca?aeii iaoiaeeee E.I.Oeaiiai? ? ni?aaao. (1989).

Ooieoe?iiaeueiee noai nenoaie aeeoaiiy o oai?eo ioe?ithaaany ca
iieacieeaie ciai?oiueiai aeeoaiiy ca aeiiiiiaith ni??iiao?a (NNI) ?
iiaaiioaoiiao?a (IO-2). Iniaeeaa cia/aiiy iaaeaaaeiny aei??thaaiith
i?eoeoiiao?ii iaeneiaeueii? (i?eiai?) oaeaeeino? aeaeeoo (IOA), yea
i?yii ei?aeth? c aaee/eiith i?ina?oo aeeoaeueieo oeyo?a ? aeicaiey?
aecia/eoe nooi?iue a?iio?aeueii? iano?oeoe??.

Aeey aea/aiiy ooieoe?iiaeueiiai noaio aiaeie?eiii? nenoaie i?iaiaeeee
?aae?i?ioiiee aiae?c (??A) e?eueeino? ai?iii?a o ieaci? e?ia?,
aecia/aiiy 17eaoinoa?i?ae?a (17-EN) o na/? ? oeueo?acaoeiaa
aeine?aeaeaiiy ueoiaeaeii? caeice. Ca iaoiaeii ??A aea/aany ai?no oaeeo
ai?iii?a: oie?o?ii?i, etho?ii?i, i?ieaeoei, o?eeiaeoe?ii?i (O3),
oe?ienei (O4), oanoinoa?ii, ano?aae?ie, i?iaanoa?ii, ei?oecie, a oaeiae
aecia/aeeny oe?ieneica’ycoth/ee aeiaoe?i (OCA), oe?aio?iiiee aeiaoe?i
(OOA) ? aioeo?ea aei oe?aiaeiaoe?io. Aeey aecia/aiiy ai?iii?a
aeei?enoiaoaaeeny noaiaea?oi? iaai?e ?aaeoea?a. Oie?o?ii?i ? etho?ii?i
aecia/aee, aeei?enoiaoth/e iaa?? ?aaeoea?a o?aioeocnueei? o??ie
IMMUNOTECH, a ?io? – ca aeiiiiiaith ?aaeoea?a aini?ic?aooieiaiai
aeine?aeiiai ae?iaieoeoaa ?inoeoooo a?ii?aai?/ii? o?i?? Aeaaeai?? iaoe
?anioae?ee A?ea?onue (?AIO AI?A). Aea/ath/e ai?no ai?iiiaeueieo
iaoaaie?o?a o na/?, aecia/aee 17-EN (a iniiaiiio iaoaaie?oe noaoaaeo
ai?iii?a) oa 17-EAN (iaoaaie?oe aetheiei?oeei?ae?a) ca iaoiaeii
E.E.Norymberski (1955) a iiaeeo?eaoe?? TH.A.Eoea/eianueeiai ?
A.N.Ia?’?iei (1969). Aeine?aeaeaiiy i?iaiaeeeeny ia aacao iaeanii?
?aae?i?cioiiii? eaai?aoi??? e iaeaniiai aiaeie?eiieia?/iiai aeeniaina?o.

?ioiieia?/i? aeine?aeaeaiiy aeeth/aee: 1) aecia/aiiy noaio O- ?
A-ee?oeiii? nenoaie ?ioi?oaoo c aeei?enoaiiyi iaoiaeo ?icaoeiooai?aiiy;
2) aiae?c eiioeaio?aoe?? ne?iaaoeiaeo ?ioiiaeiaoe?i?a iaoiaeii
?aae?aeueii? ?ioiiaeeooc?? ca Mancini et al., 1965; 3) ioe?ieo ??aiy
ne?iaaoeiaiai IgE ca aeiiiiiaith oethi?anoeaioiiai aea?aini?aaioiiai
oanoo (FAST).

Aeey niaoeeo?/ii? aea?aiae?aaiinoeee aeei?enoiaoaaeeny nea?eo?eaoe?ei?
oe??i? oanoe ? niaoeeo?/ia ae?aaiinoeea aea?a?? in vitro. Inoaiiy
aeeth/aea: 1) aecia/aiiy niaoeeo?/ieo IgE oa IgG4 ca iaoiaeii FAST; 2)
?aaeoe?th niaoeeo?/iiai eaeeie?co ca i?e?iiiaeeo?eaoe??th C.I.O?aoyeaae/
oa ?i. (1980); 3) iaoiae «aeyoeiooai?aiiy», ?ic?iaeaiee A.I.Iaiieiaith
oa ?i. (1981); 4) ?aaeoe?th oaeaeeino? in?aeaiiy a?eo?ioeeo?a c
iaaeeeaiaioaie (Iaeeiaeiaa A.A. oa ?i., 1985)

Noaoenoe/iee aiae?c ?acoeueoao?a aeine?aeaeaiiy cae?enithaaany ia
ia?niiaeueiiio eiii’thoa?? ca aeiiiiiaith noaoenoe/iiai iaeaoa
“Stat?st?na” (NOA).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. C iaoith aea/aiiy aieeao
??ciiiai?oieo oaeoi??a ia aeieeiaiiy ? ?icaeoie a?iio?aeueii? anoie
i?iaaaeaiee aeaoaeueiee aiae?c aiaiiaco o 150 ae?oae ioaa?oaoiiai a?eo c
aeei?enoaiiyi niaoe?aeueii? aieaoe-iieooaa/a. Aiae?c i?e/ei aeieeiaiiy
caoai?thaaiiy aeicaieea i?aeoaa?aeeoe i?ia?aeio ?ieue niaaeeiai?
noeeueiino? a aaiac? aeaii? iaoieia??. Aeiaaeee aoii?/ieo caoai?thaaiue
ca?a?no?iaai? o 76,7 % n?iae oai?eo ae?oae, ui cia/ii ia?aaeuo?
aiaeia?/iee iieaciee (15 %) o eiio?ieuei?e a?oi? caei?iaeo i?aee?oe?a.

Anoaiiaeaii, ui ?aae?caoe?? niaaeeiai? noeeueiino? ni?eythoue: oe?aeeea?
aioaiaoaeuei? oaeoi?e (ia?aoe?iiaeueia oa?/oaaiiy aaa?oii? – 73,3 %
aeiaaee?a, aaeeaaiiy e?e?a – 19,3 %, aanoice aaa?oieo –34,5 %,
i?ioan?ei? (16,7 %) ? iiaooia? (27,3 %) eiioaeoe c o?i?/ieie oa
e?ea?nueeeie ?a/iaeiaie); ia?eiaoaeueia aioeaoaeiiao?y (6,7 %); /ano?
aino?? ?ani??aoi?i? a??oni? ?ioaeoe?? (40,0 %).

Aaciina?aaeiueith i?e/eiith ?icaeoeo ia?oeo i?enooi?a a?iio?aeueii?
anoie a ianoaaeaieo ae?oae iae/ano?oa aoee aea?aaie aeiiaoiueiai ieeo ?
ieeeo ?ineei, ??aeoa aea?aaie eioa, i??’y iiaeooee oiui.

Iiaoi?i? i?enooie caoai?thaaiiy o ae?oae ioaa?oaoiiai a?eo iae/ano?oa
i?iaieoaaeeny oaeeie o?eaa?ieie oaeoi?aie: aea?aaie (70,0 %), aino??
?ani??aoi?i? a??oni? ?ioaeoe?? (64,0 %), iaaei??i? o?ce/i? (66,6 %) oa
aiioe?ei? (10,0 %) iaaaioaaeaiiy, iaoaioaeoi?e (50,0 %), ai?iiiaeueiee
aeenaaeain o ae?a/aoie o ia?aaeiaino?oaeueiiio ia??iae? (85,9 %).
Aeyaeaiiy o?eaa?ieo oaeoi??a aeicaiey? onoiooe aai oi/a a ciaioeoe ?o
aieea ia i?aai?ci, ui ni?ey? iieaaoaiith ia?aa?ao ? iie?ioaiith i?iaiico
caoai?thaaiiy.

Aeey ae?aaiinoeee a?iio?aeueii? anoie o i?aee?oe?a aeei?enoiaoaaany
aeaniee ae?aaiinoe/iee aeai?eoi (?en. 1). Iniiaith aeey ae?aaiico aoee
oeiiaee aiaiiac, ee?i?ea caoai?thaaiiy, iieacieee ooieoe?e i?aai?a
ciai?oiueiai aeeoaiiy. I?iaiaeeeiny niaoeeo?/ia aea?aieia?/ia
oanooaaiiy. Aiae?c eiai ?acoeueoao?a aeicaieea aecia/eoe no?oeoo?o
nainea?e?caoe?? o ae?oae ioaa?oaoiiai a?eo. Na?aae 98 ianoaaeaieo
i?aee?oe?a iae/ano?oa ?a?no?oaaeany aeniea nainea?e?caoe?y aei aea?aai?a
aeiiaoiueiai (73,4 % aeiaaee?a) /e a?ae?ioa/iiai (57,1 %) ieeo, oa?/iaeo
i?iaeoeo?a (53,1 %). ??aeoa niinoa??aaeany i?aeaeuaia nainea?e?caoe?y
aei ieeeiaeo aea?aai?a (51,0 % oai?eo) ? i??’y iiaeooee (36,7 % oai?eo).
Aenieee ??aaiue nainea?e?caoe?? aei ai?aea?iaeueieo aea?aai?a oaa?ei
aeyaeaiee o 35,7 % iaoe??io?a.

A?iio?aeueia anoia o i?aee?oe?a aeoaea ??aeei aoea ?cieueiaaiei
caoai?thaaiiyi. Ia?aaaaeii o oaeeo oai?eo niinoa??aaeany noiooiy
iaoieia?y, yea nooo?ai aieeaaea ia ia?aa?a iniiaiiai caoai?thaaiiy
(aea?a?/ia ?eiineioniiao?y – 34,7 % oai?eo, a?ia?o?io?y ieaaeaeee?a –
42,0 %, iaoieia?y aaiaoia?e?a?ii? nenoaie – 53,3 %, o?ii?/iee
aano?iaeoiaeai?o – 28,0 %).

Oaaeeoey 2

E?eoa??? aaaeeino? a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo

Aea/aiiy iniaeeainoae ee?i?/iiai ia?aa?ao a?iio?aeueii? anoie aeyaeei,
ui o ae?oae ioaa?oaoiiai a?eo ia?aaaaeaea na?aaeiueiaaaeea oi?ia
caoai?thaaiiy (44,7 % aeiaaee?a), a aaaeea ? eaaea ae?aaiinooaaeeny c
i?eaeecii iaeiaeiaith /anoioith (a?aeiia?aeii 26,6 % ? 28,7 %). Aiae?c
oa?aeoa?o ia?aa?ao a?iio?aeueii? anoie o 3 a?eiaeo a?oiao ae?oae (? –
150 i?aee?oe?a, ?? – 50 ae?oae a?ae 4 aei 8 ?ie?a, ??? – 80 ae?oae
i?ciueiai i?aioaa?oaoiiai a?eo) iieacaa, ui o ae?oae i?ciueiai
i?aioaa?oaoiiai a?eo aaaeeee ia?aa?a a?iio?aeueii? anoie ?a?no?o?oueny
iae??aeoa. Aiaeii/an o aeaio ?ioeo a?oiao aeine?aeaeaiiy oey oi?ia
caoai?thaaiiy cono??/a?oueny c iaeaea iaeiaeiaith /anoioith (?en. 2).

?en. 2. Aiae?c aaaeeino? ia?aa?ao a?iio?aeueii? anoie o ae?oae ??cieo
a?eiaeo a?oi

I?iaaaeai? aeine?aeaeaiiy iieacaee, ui ioa?oaoiee a?e iiaeia aaaaeaoe
oaeoi?ii ?eceeo ?icaeoeo anoiaoe/iiai noaio, ine?eueee c 89 ae?oa, ye?
iinooieee a ee?i?eo a anoiaoe/iiio noaoon?, 44 (49,0 %) – ae?oe oe???
a?eiai? a?oie.

Iao? aeine?aeaeaiiy aeiaaee, ui anoia a ioaa?oaoiiio a?oe? ci?ith? na?e
ia?aa?a. O 49,1 % ae?a/aoie a?i iia??oo?oueny, aiaeii/an o a?eueoino?
oeii/ee?a (84,2 %) niinoa??aa?oueny ee?i?/ia iie?ioaiiy. Iia??oaiith
ia?aa?ao oai?iae ni?ey? c?inoaiiy o?eaa?iiai iaaaioaaeaiiy ia i?aai?ci
i?aee?oe?a, a naia: aeniea /anoioa A?A?, oa?aeoa?ia aeey i?aee?oe?a
aiioe?eia eaa?euei?noue, ia?aici?noue. I?eoaiaii? ioaa?oaoiiio a?eia?
ai?iiiaeuei? c?ooaiiy a i?aai?ci? i?ecaiaeyoue aei oiai, ui oeii/eee ?
ae?a/aoea ii-??ciiio ?aaaothoue ia oaea o?eaa?ia iaaaioaaeaiiy.

A ia??iae noaoaaiai aeic??aaiiy oa noaiiaeaiiy ?ai?iaeoeoeaii? ooieoe??
i?aai?cio aaeeea cia/aiiy iaaoaathoue noaoaa? ai?iiie. O oeueiio a?oe?
i?ia?aneaii i?aeaeuo?oueny aiiaaeio?iiia ooieoe?y a?iio?ca ? c?inoa?
aeoeai?noue aiiaae.

Ioe?ithth/e ooieoe?iiaeueio aeoeai?noue ?ai?iaeoeoeaii? nenoaie o 50-oe
ae?a/aoie ioaa?oaoiiai a?eo, ie i?iaiaeeee aeine?aeaeaiiy a aeaio
a?oiao: ia?oo neeaee 12 iaoe??ioie, o yeeo iaino?oaoe?? ua ia ii/aeeny,
a ae?oao – 38 ae?a/ao c iayaiei iaino?oaeueiei oeeeeii. O 12-oe
ae?a/aoie ae?oai? a?oie iaino?oaeueiee oeeee aoa ?aaoey?iee, o?eaae?noth
27–30 aei?a. O ?aooe (26) iaoe??ioie a?aecia/aany ia?aaoey?iee
iaino?oaeueiee oeeee, i?e/iio eiai noaiiaeaiiy caoyaoaaeiny, ii??aiyii
c? caei?iaeie ?iaanieoeyie. Ai?no aiiaaeio?iiieo ? noaoaaeo ai?iii?a, a
oaeiae i?ieaeoeio a e?ia? ianoaaeaieo ae?a/aoie ioaa?oaoiiai a?eo,
oai?eo ia a?iio?aeueio anoio, iaaaaeaii a oaae. 3.

Oaaeeoey 3

Eiioeaio?aoe?y aiiaaeio?iiieo, noaoaaeo ai?iii?a ? i?ieaeoeio a e?ia?
ae?a/aoie ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio

I?ei?oea. * ? < 0,05 – iaaaaeaii a?aeiinii iieaciee?a o caei?iaeo iaeiie?oie. Aiae?c io?eiaieo ?acoeueoao?a aeicaieea aeyaeoe o ae?a/aoie ae?oai? a?oie cieaeaiiy ??aiy i?iaanoa?iio ii??aiyii c eiai iieacieeaie o caei?iaeo iaeiie?oie. O ia?o?e oac? iaino?oaeueiiai oeeeeo a ianoaaeaieo iaoe??ioie ??aaiue i?iaanoa?iio noaiiaea (0,8±0,3) iiieue/e, o ae?oa?e oac? – (3,8±0,4) iiieue/e, oiae? ye o caei?iaeo, a?aeiia?aeii – (1,7±0,25) iiieue/e (? < 0,05) ? (4,9±0,5) iiieue/e (? < 0,05). Iiaeeeai, iane?aeeii oaeeo a?aeoeeaiue ? a?eueo o?eaaea noaiiaeaiiy iaino?oaeueii? ooieoe?? o ae?a/aoie, oai?eo ia a?iio?aeueio anoio. I?e aeine?aeaeaii? ??aiy ano?aae?ieo ? oanoinoa?iio ia aoei aeyaeaii aeinoia??ii? ??cieoe? i?ae oeeie iieacieeaie o oai?eo ? caei?iaeo ae?a/aoie. ??ai? i?ieaeoeio, etho?ii?io ? oie?o?ii?io a?aeiia?aeaee ii?iaeueiei a?eiaei eieeaaiiyi. O i?ioean? aiae?co aeyaeaii ei?aeyoeaiee ca’ycie ??aiy ano?aae?ieo c oie?o?ii?iii (r = +0,71, p < 0,05), i?iaanoa?iio c etho?ii?iii (r = +0,67, p < 0,05). O i?ioean? ?iaioe ie /?oei a?aene?aeeiaoaaee caeaaei?noue i?ae ?icaeoeii caaino?aiiy a?iio?aeueii? anoie ? oacith iaino?oaeueiiai oeeeeo: o oai?eo ae?a/aoie niinoa??aaeiny caaino?aiiy anoie ia?aae iaino?oaoe??th. Ia iaoo aeoieo, oe? ci?ie iiyniththoueny i?aeaeuaiiyi ai?noo ano?iaai?a o ae?oa?e oac? iaino?oaeueiiai oeeeeo ? ii?ooaiiyi ni?aa?aeiioaiiy ano?iaaie/i?iaanoa?ii. O aeine?aeaeaiiyo White A., Kent J.R. (1977) anoaiiaeaii, ui ano?aae?ie i?ecaiaeeoue aei a?ia?o?io?? e?ioi?aeii? oeaieie, ui noi?iaiaeaeo?oueny i?aeaeuaiiyi caeaoiino? aei neioaco aioeo?e. Ioaea, c?inoaiiy ai?noo ano?iaai?a aeyaey? noeioethth/ee aieea ia ?ioiio a?aeiia?aeue ? ?iaeoue i?aai?ci ae?a/eiee iniaeeai a?aceeaei aei ae?? o?eaa?ieo /eiiee?a. Aeo?ae c oaei? neooaoe?? ia iiaeia ooeaoe, aieeaath/e ia ai?iiiaeueiee aeenaaeain, ine?eueee a?i ? o?c?ieia?/iei aeey ae?a/eiee. Canoinoaaiiy ai?iiiaeueieo i?aia?ao?a aeey e?eoaaiiy o?c?ieia?/ieo a?aeoeeaiue o ia??iae noaoaaiai aeic??aaiiy iiaea i?ecaanoe aei iaaacia/ieo aeey i?aai?cio ii?ooaiue i?e?iaeiiai i?ioeano naii?aaoeyoe?? e aaeaioaoe??. Eiioeaio?aoe?y oanoinoa?iio a oeii/ee?a ioaa?oaoiiai a?eo, ye? oai??thoue ia a?iio?aeueio anoio, aoea a iaaeao 1,1–4,6 ia/e, ui a?aeiia?aea? a?eiaei ii?iaoeaiei eieeaaiiyi. Iaeiae, o ieo niinoa??aaeany oaiaeaioe?y aei aeayeiai cieaeaiiy oaii?a ?inoo ??aiy oeueiai ai?iiio ii??aiyii c? caei?iaeie ?iaanieeaie. O 12–13-??/iiio a?oe? ??aaiue oanoinoa?iio o oai?eo oeii/ee?a i?aeoe/ii ia a?ae??ciyany a?ae caei?iaeo. Aiaeii/an, aiae?c ??aiy oeueiai ai?iiio o i?aee?oe?a 14–15-oe ?ie?a iieacaa, ui ai?no oanoinoa?iio o oai?eo aeaui ieae/ee, i?ae o caei?iaeo (a?aeiia?aeii (3,1±0,8) ia/e ? (3,8±0,7) ia/e, ? > 0,05). A?aeiii, ui i?ae aieeaii oanoinoa?iio oi?iothoueny iniiai?
aoi?eii? noaoaa? iciaee. Oeii/eee, a yeeo ae?aaiinoiaaii aaaeeee ia?aa?a
a?iio?aeueii? anoie, a?aenoaaaee o noaoaaiio aeic??aaii?. ??aaiue
oanoinoa?iio o ieo aoa aeinoia??ii ieae/ei, i?ae o caei?iaeo ?iaaniee?a
(a?aeiia?aeii (2,0±0,82) ia/e ? (2,9±0,91) ia/e, p < 0,05). Aaoi?e iiiaeeiieeo i?aoeue a?aecia/athoue noi?aneaiee aieea oanoinoa?iio ia ?ioiio a?aeiia?aeue (*aaioa?aa A.O., 1979). Ia iaoo aeoieo, iiceoeaia aeeiai?ea caoai?thaaiiy o oeii/ee?a, ye? anooieee a ioaa?oaoee ia??iae ?icaeoeo, iia’ycaia naia c i?aeaeuaiiyi ??aiy oanoinoa?iio. Oaeei /eiii, i?eoaiaii? ae?oyi ioaa?oaoiiai a?eo ci?ie ai?iiiaeueiiai noaoono aieeaathoue ia ia?aa?a a?iio?aeueii? anoie, yea, a naith /a?ao, oaeiae coiiaeth? ai?iiiaeuei? c?ooaiiy a i?aai?ci? i?aee?oea. Oe? c?ooaiiy caeaaeaoue a?ae aaaeeino? ia?aa?ao ? ia??iaeo caoai?thaaiiy. Ie aea/aee aeoeai?noue iaaeie?eiaeo ? ueoiaeaeii? caeic o 115 ae?oae ??ciiai a?eo (95 – i?aee?oee ? 20 – ae?oe a?eii a?ae 2 aei 11 ?ie?a), iaiaaath/enue ooi/ieoe ?ieue oeeo iaaecae/aeii aaaeeeaeo i?aai?a a aaeaioaoe?eieo i?ioeanao ia ??cieo aoaiao ?icaeoeo a?iio?aeueii? anoie. O i?ioean? aeine?aeaeaiue anoaiiaeaii, ui ooieoe?iiaeueia aeoeai?noue iaaeie?eiaeo ? ueoiaeaeii? caeic caeaaeeoue a?ae aaaeeino? ia?aa?ao ? o?eaaeino? anoie. O ae?oae c eaaeith ? na?aaeiueiaaaeeith oi?iaie a?iio?aeueii? anoie aeoeai?noue ei?e iaaeie?eiaeo caeic o ia??iae i?ae i?enooiaie nooo?ai ia a?ae??ciyeany a?ae aiaeia?/ieo iieaciee?a o caei?iaeo. O?eueee i?ae /an i?enooio anoie ie niinoa??aaee o ieo oeiiao aeey no?ano ?aaeoe?th ei?e iaaeie?eiaeo caeic ?c i?aeaeuaiiyi ??ai?a ei?oecieo a e?ia? ? 17-EAN a na/?. I?e/iio, oaea ?aaeoe?y aoea aeanoeaith aeey an?o a?eiaeo a?oi ae?oae. I?aeaeuaiiy ??aiy ei?oecieo a ie?aieo iaoe??io?a ia?aaeuoaaei iieacieee caei?iaeo iaeiie?oe?a o 2–3 ?ace ? aeinyaaei 1200 iiieue/e ? aeua. O ae?oae c aaaeeith oi?iith a?iio?aeueii? anoie a?aecia/aeany oaiaeaioe?y aei cieaeaiiy ??aiy ei?oecieo a ne?iaaooe? e?ia? o ia??iae i?ae i?enooiaie. *ei aaae/ei ? o?eaae?oei aoa ia?aa?a caoai?thaaiiy, oei ieae/eie aoee oe? iieacieee: eiao?oe??io ei?aeyoe?? i?ae aaaee?noth caoai?thaaiiy ? oaiaeaioe??th aei cieaeaiiy ??aiy ei?oecieo noaiiaea r = + 0,65 (p < 0,05). Oaeo oaiaeaioe?th ie a?aecia/aee a ae?oae on?o a?eiaeo a?oi (?en. 3). ?en. 3. ??aaiue ei?oecieo o e?ia? ae?oae caeaaeii a?ae aaaeeino? a?iio?aeueii? anoie Io?eiai? ?acoeueoaoe i?aeoaa?aeaeothoue ?nioth/o aeoieo i?i oa, ui ooieoe?y iaaeie?eiaeo caeic ii?ooo?oueny aiane?aeie /anoeo iiaoi?ieo i?enooi?a, ye?, ye no?ania? /eiieee, aeeeeeathoue nii/aoeo ?o a?ia?ooieoe?th, a iio?i aeniaaeaiiy. I?ioa, ??aaiue ei?oecieo aeoaea ??aeei (eeoa o 2,6 % ae?oae) cieaeoaaany ii??aiyii c a?eiaeie ii?iaoeaieie eieeaaiiyie. Oae? ci?ie ca?a?no?iaai? o aeaio ae?oae ioaa?oaoiiai a?eo e o aeai??/iiai oeii/eea c oeiiiaaae??th. A on?o oeeo aeiaaeeao oai?iaa iaea aeoaea aaaeeee ia?aa?a ? iaaaeaeaaoii e?eoaaeany. Oaeei /eiii, aea/aiiy ooieoe?iiaeueii? aeoeaiino? iaaeie?eiaeo caeic o ae?oae, oai?eo ia a?iio?aeueio anoio, aeicaieeei anoaiiaeoe ci?ie a iieacieeao ei?oecieo ? 17-EAN, ye? caeaaeaee a?ae aaaeeino? ? ia??iaeo oai?iae, aea ia a?ae a?eo ianoaaeaieo. Cieaeaiiy ??aiy ei?oecieo ca?a?no?iaaia o 2,1 % (2 c 95) i?aee?oe?a o i?aei?enooiiiio ia??iae? ia oii? aaaeeiai ia?aa?ao a?iio?aeueii? anoie. Aiae?c ooieoe?iiaeueii? aeoeaiino? ueoiaeaeii? caeice o i?aei?enooiiee ia??iae aeicaieea aeyaeoe o 12,6 % (12 c 95) i?aee?oe?a i?aeaeuaiiy ??aiy oe?ieneio o aeiaaeeo aaaeeiai ia?aa?ao a?iio?aeueii? anoie. Aeeiai?ea ??aiy ai?iii?a ueoiaeaeii? caeice a ??ci? ia??iaee caoai?thaaiiy aea/aeany o aeaio a?oiao i?aee?oe?a. Ia?oo a?oio neeaee 18 ae?oae ?c aaaeeith oi?iith a?iio?aeueii? anoie, a ae?oao – 12 c eaaeith ? na?aaeiueiaaaeeith oi?iaie caoai?thaaiiy. Aeine?aeaeaiiy iieacaee, ui o ae?oae c aaaeeith oi?iith a?iio?aeueii? anoie aeinoia??ii cieaeoaaany ??aaiue o?eeiaeoe?ii?io (O3), ui noi?iaiaeaeoaaeiny i?aeaeuaiiyi eiioeaio?aoe?? oe?ieneio (O4). Iniaeeai /?oei oae? ci?ie a?aecia/aii o ia??iae i?enooio anoie (oaae. 4). Oaaeeoey 4 Ooieoe?iiaeueia aeoeai?noue ueoiaeaeii? caeice o i?aee?oe?a, oai?eo ia a?iio?aeueio anoio (M±m, p) Oaeee oa?aeoa? aeyaeaieo ci?i, iiaeeeai, iia'ycaiee c oei, ui o?eeiaeoe?ii?i ia? a?eueoo aeoeai?noue ? a 10 ?ac?a aeuo oaeaee?noue iaoaaie?cio ii??aiyii c oe?ieneiii (Ea?aoaiyi A., Caoa?ueaaa A., 1988). Ai?no oe?io?iiiiai aeiaoe?io (OOA) ? oe?ieneica'ycoth/iai aeiaoe?io (OCA) o oai?eo ae?oae aeinoia??ii ia a?ae??ciyany a?ae iieaciee?a caei?iaeo ae?oae. Ioaea, ?acoeueoaoe iaoeo aeine?aeaeaiue iiaeooue na?ae/eoe i?i oa, ui aeoeaaoe?y ueoiaeaeii? caeice iineoue ooieoe?iiaeueiee oa?aeoa? ? coiiaeaia no?anii. I?aeaeuaiiy eiioeaio?aoe?? O4 ni?yiiaaii ia noeioeyoe?th ieneaeaoe?eieo i?ioean?a, ?ioaineai?noue yeeo cieaeo?oueny a oiiaao a?iien??, ni?e/eiaii? i?enooiaie anoie. I?iaaaeai? iaie ?ioiieia?/i? aeine?aeaeaiiy iieacaee, ui a a?eueoino? ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio, ?a?no?othoueny ?ioiieia?/i? ia?ea?e aoii??, ui aeicaiey? i?aeoaa?aeeoe aoii?/io i?e?iaeo caoai?thaaiiy. Aecia/aiiy iieaciee?a ee?oeiiiai ?ioi?oaoo cae?eniaii o 86 i?aee?oe?a o i?aei?enooiiiio ia??iae?. O 40 (46,2 %) oai?eo niinoa??aaeiny cieaeaiiy e?eueeino? oaio?e?ii/ooeeaeo O-e?ioioeeo?a (O-noi?ani??a), o 24 (27,9 %) – ca?a?no?iaaia i?aeaeuaia e?euee?noue oaio?e?iiia/ooeeaeo O-e?ioioeeo?a (O-oaeia??a). O 52 (60,5 %) i?aee?oe?a eiinoaoiaaia i?aeaeuaiiy ?ioii?aaoeyoi?iiai ?iaeaeno (ni?aa?aeiioaiiy oaeia?e/noi?ani?e). Iieacieee ee?oeiiiai ?ioi?oaoo o ae?oae ioaa?oaoiiai a?eo caeaaeii a?ae aaaeeino? caoai?thaaiiy i?aaenoaaeai? o oaae. 5. Oaaeeoey 5 Iieacieee ee?oeiiiai ?ioi?oaoo o ae?oae ioaa?oaoiiai a?eocaeaaeii a?ae aaaeeino? caoai?thaaiiy (M±m) I?ei?oea. * ? < 0,05 – iaaaaeaii a?aeiinii iieaciee?a o caei?iaeo iaeiie?oe?a Ai?no ?ioiiaeiaoe?i?a o ne?iaaooe? e?ia? aea/aany o ??ci? ia??iaee caoai?thaaiiy o aeaio a?oiao ae?oae. Ia?oo (iniiaio) a?oio neeaee 50 ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio. O ae?oao (eiio?ieueio) a?oio oa?eoee 30 ae?oae a?eii a?ae 4 aei 11 ?ie?a, ye? oaeiae oai??ee ia a?iio?aeueio anoio. Iieacieee ai?noo ?ioiiaeiaoe?i?a o ne?iaaooe? e?ia? ianoaaeaieo ae?oae i?aaenoaaeai? o oaae. 6. Oaaeeoey 6 Ai?no ?ioiiaeiaoe?i?a o ne?iaaooe? e?ia? ae?oae, oai?eo ia a?iio?aeueio anoio(M±m) I?ei?oea: * p < 0,01 – iaaaaeaii a?aeiinii iieaciee?a o caei?iaeo iaeiie?oe?a Aiae?c ai?noo ?ioiiaeiaoe?i?a ia aeyaea aeinoia??ii? ??cieoe? i?ae ??cieie a?eiaeie a?oiaie ae?oae, aea aeicaieea anoaiiaeoe ci?ie a iieacieeao, ye? caeaaeaoue a?ae ia??iaeo caoai?thaaiiy. I?ae /an caaino?aiiy o a?eueoino? ianoaaeaieo niinoa??aaeiny iacia/ia i?aeaeuaiiy ai?noo IgG, cieaeaiiy ??ai?a IgA oa IgE. I?e/iio, cieaeaiiy inoaiiueiai ?a?no?oaaeiny ii??aiyii c eiai ??aiai o i?aei?enooiiiio ia??iae? e, i/aaeaeii, iiynith?oueny ca'ycoaaiiyi ?aaa?i?a c aioeaaiaie. ??aaiue IgM a?aeiia?aeaa ii?iaoeaiei a?eiaei eieeaaiiyi. O i?aei?enooiiiio ia??iae? o 68,2 % (55 c 80) ae?oae ca?a?no?iaaia cia/ia i?aeaeuaiiy ai?noo caaaeueiiai IgE ? iacia/ia ca?eueoaiiy ??aiy IgA (54,3 % – 43 c 80). Ne?ae a?aecia/eoe, ui c? c?inoaiiyi aaaeeino? ia?aa?ao a?iio?aeueii? anoie iciaee aeec?ioiiaeiaoe?iai?? i?aeneethaaeeny. Aeey aeyaeaiiy aioeo?e eeano IgE iaaeinoaoiuei aecia/eoe eeoa caaaeueiee IgE, iaiao?aeii i?iaiaeeoe aeine?aeaeaiiy niaoeeo?/ieo aioeo?e (niaoeeo?/iee IgE). Ie aecia/eee ??aaiue niaoeeo?/ieo IgE o 123 ae?oae ??ciiai a?eo, ye? oai??ee ia a?iio?aeueio anoio ? e?eoaaeeny a aea?aieia?/iiio a?aeae?eaii? oa aea?aieia?/iiio eaa?iao? eiinoeueoaoeaii? iie?ee?i?ee Euea?anueei? i?nueei? aeeoy/i? ee?i?/ii? e?ea?i?. Aeine?aeaeaiiy i?iaiaeeeenue o aeaio a?oiao. Ia?oo (iniiaio) a?oio neeaee 65 ae?oae ioaa?oaoiiai a?eo (12–15 ?ie?a), ae?oao (eiio?ieueio) – 58 ae?oae a?eii a?ae 4 aei 11 ?ie?a. Aeine?aeaeaiiy i?iaiaeeeenue ca aeiiiiiaith oethi?anoeaioiiai aea?aini?aaioiiai oanoo (FAST) c aeei?enoaiiyi aia?aoa ae?iaieoeoaa NOA – oethi?i-FAST-?a?no?aoi?a. I?iaaaeai? ianoaaeaiiy aeicaieeee ca?a?no?oaaoe i?aeaeuaiiy aea?aaiiniaoeeo?/iiai IgE o 89,4 % ae?oae. Na?aae 65 iaoe??io?a ia?oi? a?oie aea?aaiiniaoeeo?/i? IgE-aioeo?ea aeyaeai? o 87,6 % (57 c 65) aeiaaee?a, a na?aae 58 i?aaenoaaiee?a ae?oai? a?oie – o 91,3 % (53 c 58). Aiae?coth/e ?acoeueoaoe niaoeeo?/ii? aea?aiae?aaiinoeee, ie aecia/eee iniaeeaino? no?oeoo?e nainea?e?caoe?? o ae?oae ??ciiai a?eo, oai?eo ia a?iio?aeueio anoio (oaae. 7). Oaaeeoey 7 Aeine?aeaeaiiy aea?aaiiniaoeeo?/ieo IgE – aioeo?e o ae?oae,oai?eo ia a?iio?aeueio anoio I?ei?oea. n – e?euee?noue ianoaaeaieo oai?eo, m – e?euee?noue oai?eo, o yeeo aeyaeaiee i?aeaeuaiee ai?no niaoeeo?/ieo IgE-aioeo?e, m/n – a?aenioeiaa ni?aa?aeiioaiiy C oaaeeoe? aeaeii, ui o ae?oae ioaa?oaoiiai a?eo aeinoia??ii /ano?oa ?a?no?oaaeany aeniea /ooeea?noue aei aea?aai?a aeiiaoiueiai ieeo ? ieeeo ?ineei. Aiaeii/an, na?aae oai?eo iieiaeoi? a?eiai? a?oie aeinoia??ii /ano?oa aeyaeyany i?aeaeuaiee ??aaiue niaoeeo?/iiai IgE o ?ac? noeioeyoe?? oa?/iaeie aea?aaiaie. Aeniea /ooeea?noue aei ai?aea?iaeueieo aea?aai?a ca?a?no?iaaia a iaio a?oiao c i?eaeecii iaeiaeiaith /anoioith. Oae? ?acoeueoaoe, ia iaoo aeoieo, iiaeia iiynieoe iniaeeainoyie oi?ioaaiiy ? a?eiai? ao?ieia?/ii? aaiethoe?? aoii?/iiai oiio o ae?oae. Ii/aoeiaith eaieith oeueiai i?ioeano ? oa?/iaa aea?a?y, yea ?aae?co?oueny aaea a ia?o? i?nyoe? aeeooy. C a?eii ii/eia? aeyaeyoeny i?aeaeuaia /ooeea?noue aei ?iaaeyoe?eieo aea?aai?a (iiaooiaeo, ai?aea?iaeueieo, ieeeiaeo). C iaoa?oaaiiyi ?iaaeyoe?eii? aea?a?? ni?aiaaea? aeaatho ?ani??aoi?ieo aea?aic?a. Iinooiiai c a?eii c?inoa? ? ?icoe?th?oueny iie?aea?a?y. Ni?anoaaeyth/e ?acoeueoaoe aecia/aiiy niaoeeo?/ieo IgE c? nea?eo?eaoe?eieie oanoaie, ie aeyaeee i?yiee ei?aeyoe?eiee ca'ycie i?ae oeeie iieacieeaie, i?e yeiio eiao?oe??io ei?aeyoe?? (r) aeey ??cieo aea?aai?a noaiiaea a?ae 0,4 aei 0,65. Iiaeeaeaiee aiae?c i?e/eiieo ? ni?eyoeeaeo oaeoi??a ?icaeoeo a?iio?-aeueii? anoie, aea/aiiy iniaeeainoae iaoiaaiaco, ee?i?ee ? e?eoaaiiy oeueiai caoai?thaaiiy aeicaieeee iai i?iaiicoaaoe ?icaeoie aaaeei? oi?ie a?iio?aeueii? anoie o i?aee?oe?a. Na?aae oe?eiai ?yaeo oaeoi??a, ui ni?eythoue ?icaeoeo aaaeei? oi?ie oeueiai caoai?thaaiiy, ie aeae?eeee aeae?eueea, ye? ia i?aenoaa? iaoeo aeine?aeaeaiue aoee iaea?eueo aieeaiaeie. Aei ieo oa?eoee: 1) niaaeeiaa noeeuei?noue aei aea?a?? ii iaio e?i?yo; 2) ia?eiaoaeueia iaoieia?y oeaio?aeueii? ia?aiai? nenoaie; 3) noiooi? o?aaeaiiy oe??e aea?a?/iiai aaiaco aai aeac?aee ia ieo a aiaiiac?; 4) ?aii?e ii/aoie caoai?thaaiiy (ia?o? ai?ciaee a?iioiiano?oeoe?? ae?aaiinoiaai? o a?oe? a?ae 6 i?n. aei 1,5 ?ieo); 5) i?ci? caa?oaiiy aei niaoe?ae?noa (o?eaae?noue ia?aa?ao oai?iae aei iiiaioo anoaiiaeaiiy ae?aaiico ? i?ecia/aiiy aaeaeaaoii? oa?ai?? neeaaea? iiiaae 3 ?iee); 6) noaoue; 7) iniaeeaino? ia?aiai-aiioe?eii? noa?e i?aee?oea (iayai?noue ??cieo aeae?a iaa?ic?a oiui); 8) iaaaeaeaaoia aacenia oa?ai?y; 9) aaaaoi?acia? eo?ne aioeaaeoa??aeueii? oa?ai?? c i?eaiaeo caaino?aiiy caoai?thaaiiy. Ca'ycie eiaeiiai ?c ?icaeyiooeo aeua oaeoi??a c ?icaeoeii aaaeei? oi?ie a?iio?aeueii? anoie o i?aee?oe?a ioe?ithaaee ca e?eoa???i c2 ia iaeii??aei?noue aeaio aeai?ie. Aeinoia??i? eiao?oe??ioe c2 io?eiai? aeey 9 oaeoi??a, ye? i?eaaaeai? a oaae. 8. Oaaeeoey 8 Ioe?iea ?acoeueoao?a aeine?aeaeaiiy ca e?eoa???i c2 I?ioa iiieeeiai aoei a ?iaeoe inoaoi/i? aeniiaee i?i aca?iiae?th ? aieea oaeoi??a o?eueee ia i?aenoaa? aeaieo aiae?co cia/aiue c2. Aeey a?eueo aeaoaeueiiai aeine?aeaeaiiy aieeao eiiieaeno aca?iica'ycaieo oaeoi??a ia ?icaeoie aaaeei? oi?ie a?iio?aeueii? anoie o i?aee?oe?a ie aeei?enoaee iaoiae iiiaeeiii? ?aa?an??, yeee aeicaieea iai c eiiieaeno oaeoi??a a?ae?a?aoe i'youe, ui noaoenoe/ii aeinoia??ii aieeaathoue ia ?icaeoie oe??? iaoieia??, a naia: 1) noaoue; 2) noiooi? o?aaeaiiy oe??e; 3) ?aii?e ii/aoie caoai?thaaiiy; 4) iaaaeaeaaoia e?eoaaiiy; 5) ceiaaeeaaiiy aioea?ioeeaie. Aeey iiaoaeiae i?iaiinoe/ii? iiaeae? ?icaeoeo aaaeei? oi?ie a?iio?aeueii? anoie ie canoinoaaee iaoiae eia?noe/ii? ?aa?an??. Oeae iaoiae aeicaiey? aeyaeoe caeaaei?noue iciaee, ui aeine?aeaeo?oueny (aaaeea oi?ia a?iio?aeueii? anoie), iaeii/anii a?ae aeae?eueeio ?ioeo iciae ? i?iaiicoaaoe ci?io ?? a?aeiinii ci?i, aeeth/aieo o ?aa?an?eio iiaeaeue iciae. ?acoeueoaoe aiae?co c aeei?enoaiiyi iaoiaeo eia?noe/ii? ?aa?an?? i?aaenoaaeai? o oaae. 9. Oaaeeoey 9 ?acoeueoaoe ioe?iee aeine?aeaeaiue ca iaoiaeii eia?noe/ii? ?aa?an?? Aaaee?noue a?iio?aeueii? anoie iiaeia ciiaeaethaaoe oi?ioeith: R = K + 1 x1 + 2 x2 + ... + n xn , aea K – eiinoaioa, i – eiao?oe??ioe i?e eiaeiiio oaeoi??, xi – cia/aiiy oaeoi??a. I?aenoaaeaoe o oi?ioeo ?acoeueoaoe, io?eiai? ca iaoiaeii eia?noe/ii? ?aa?an??, ie ?ic?iaeee iaoaiaoe/io iiaeaeue ?icaeoeo aaaeei? oi?ie a?iio?aeueii? anoie o i?aee?oe?a: W = –6,23 + 3,11St + 2,77Su + 3,72Rp + 2,8Nl +2,5Za aea W – aaaee?noue a?iio?aeueii? anoie, St – noaoue, Su – noiooi? o?aaeaiiy oe??e, Rp – ?aii?e ii/aoie caoai?thaaiiy, Nl – iaaaeaeaaoia e?eoaaiiy, Za – ceiaaeeaaiiy aioea?ioeeaie. Oey oi?ioea oa?aeoa?eco?oueny aeinoia??i?noth io?eiaieo aeaieo ? iiaoaeiaaia ia i?aenoaa? ?ioi?iaoe?eii? aaaiiino? oaeoi??a ?eceeo. I?iaaaeaiee iaie ?ao?iniaeoeaiee aiae?c aeiaaee?a ?icaeoeo aaaeei? oi?ie a?iio?aeueii? anoie o i?aee?oe?a iieacaa, ui aeei?enoaiiy cai?iiiiiaaii? iaoaiaoe/ii? iiaeae? o ia?aaaaei?e a?eueoino? aeiaaee?a aeicaieeei a caiia?aoe oae?e neooaoe??. Cia/ia i?noea a aeine?aeaeaiiyo iaaeaaaeiny aea/aiith iniaeeainoae e?eoaaiiy a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo. A?iio?aeueia anoia – o?ii?/ia ?, aiaeii/an, aeoaea aeeiai?/ia caoai?thaaiiy, oiio i?ia?aia ?? e?eoaaiiy iiaeiia aooe o?eaaeith, aoaiiith, aeeoa?aioe?eiaaiith caeaaeii a?ae nooiaiy aaaeeino? oa ?iaeea?aeoaeueieo iniaeeainoae caoai?thaaiiy o eiaeii? aeeoeie. A?aoiaoth/e ?aeiiaiaeaoe?? I?aeia?iaeii? a?oie niaoe?ae?no?a c i?iaeai a?iio?aeueii? anoie, aeina?ae i?ia?aeieo a?o/eciyieo aea?aieia?a ? aeani? niinoa?aaeaiiy, ie aia?oa aeei?enoaee e aaeaiooaaee aeey i?aee?oe?a noaio “nooi?i/anoi?” oa?ai?? caoai?thaaiiy (oaae. 10). Ca oe??th no?aoaa??th i?ie?eiaaii 88 ae?oae. Ine?eueee iniiaith e?eoaaiiy aoea o?eaaea i?ioecaiaeueia oa?ai?y, iniaeeaa cia/aiiy a ?iaio? iaaeaaaeiny aea/aiith aoaeoeaiino? ??cieo i?aia?ao?a oe??? a?oie ? ?ic?iaoe? eiie?aoieo iieacaiue aei ?o i?ecia/aiiy o ae?oae ioaa?oaoiiai a?eo. Aoaeoeai?noue ianoa?i?aeiiai ?iaaeyoe?eiiai i?ioecaiaeueiiai i?aia?aoo “Oaeeaae” aea/aeany o 22 ae?oae, noa?oeo 12 ?ie?a, ye? oeae i?aia?ao io?eioaaee aia?oa. A aeine?aeaeaii? acyei o/anoue 15 ae?oae, o yeeo na?aaeiueiaaaeeee ia?aa?a caoai?thaaiiy ia i?aeaeaaaany aoaeoeaiiio eiio?ieth ca aeiiiiiaith ?ioaeo, ? 7 ae?oae c aaaeeith a?iio?aeueiith anoiith, ye? io?eioaaee o?eaaeee /an iacia/i? aeice (aei 200 iea ca aaeioeaeii) ?iaaeyoe?eieo noa?i?ae?a. O oaeeo aeiaaeeao, i?ecia/eaoe oaeeaae, iinooiiai, ca 4–7 aei?a, ciyee ?iaaeyoe?ei? noa?i?aee. Oaeeaae canoiniaoaaany i?ioyaii 3-o i?nyoe?a o aeiaia?e aeic? 8 ia – ii 4 ia (2 aaeeoe) 2 ?ace. O ainueie ae?oae i?ae /an aino?iai ?ani??aoi?iiai caoai?thaaiiy aeica i?aia?aoo ei?ioei/anii i?aeaeuoaaeanue aei 4 ia (2 aaeeoe) 4 ?ace ia aeaiue. Ioe?iea aoaeoeaiino? e?eoaaiiy i?iaiaeeeanue ia i?aenoaa? aeaieo uiaeaiieea naiiniinoa?aaeaiiy, ia'?eoeaiiai iaeyaeo iaoe??ioa ? aecia/aiiy ooieoe?e ciai?oiueiai aeeoaiiy. Oaaeeoey 10 I?iaaaeai? iaie aeine?aeaeaiiy iieacaee, ui o 21 (95,5 %) aeeoeie ia oii? e?eoaaiiy oaeeaaeii cia/ii ciaioeeanue neiioiiaoeea a?iio?aeueii? anoie ? iie?ioeeanue ye?noue aeeooy. Aeaii? neiioiie nooo?ai ciaioeeenue oaea aei 3 oeaeiy o 19 (86,6 %), a i?/i? – o 10 (45,4 %) oai?eo. O 6 (27,3 %) ae?oae inoaii? aeaa oeaei? e?eoaaiiy i?iyae oai?iae aoee a?aenooi?, a o 4 (18,2 %) niinoa??aaeenue eeoa ai?ciaee i?/iiai eaoeth. Cia/ii cieceeanue iio?aaa oai?eo o a?iioiaeeeyoaoe?ei?e oa?ai??. Oey oaiaeaioe?y i?ine?aeeiaoaaeany o 20 (90,9 %) ae?oae oaea a ia?o? 2 oeaei? e?eoaaiiy. I?ae /an inoaiiueiai a?aea?aeoaaiiy ee?i?ee ii??aithaaee na?aaei? aeei?enoaiiy a?iioie?oee?a ca inoaii?e oeaeaeaiue aei e?eoaaiiy ? ia?aae eiai cae?i/aiiyi. Aeyaeeinue, ui oeae iieaciee ia oii? e?eoaaiiy oaeeaaeii cia/ii ciaioeany (o 2,5–3 ?ace) a 15 (68,2 %) ae?oae, a 6 (27,3%) ae?oae i?ioyaii inoaiiueiai oeaeiy acaaae? ia aaeeaaee a?iioie?oeee. Aenieee ee?i?/iee aoaeo oaeeaaeo, a?aenooi?noue iia?/ii? ae?? aeiaiaeyoue aeioe?euei?noue aeei?enoaiiy oeueiai i?aia?aoo aeey o?eaaeiai e?eoaaiiy a?iio?aeueii? anoie na?aaeiuei? aaaeeino? o ae?oae ioaa?oaoiiai a?eo. Iniaeeaa cia/aiiy a ?iaio? iaaeaaaeiny aecia/aiith i?noey ai?iiiaeueii? oa?ai?? a e?eoaaii? a?iio?aeueii? anoie. Aoaeoeai?noue oa?ai?? ?iaaeyoe?eieie aetheiei?oeeinoa?i?aeaie (?AEN) aea/aeany o 20 ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio. C ieo 12 oai?eo io?eioaaee eiia?iiaaio aacenio oa?ai?th, ui aeeth/aea ?AEN, i?ieiiaiaai? i?aia?aoe oaio?e?io aai i?ieiiaiaai? 2-aaii?noe, a 8 – io?eioaaee eeoa ?AEN. I?aea?? iioeiaeueiiai aeicoaaiiy ? ?aaeeio aaaaeaiiy ?AEN i?iaiaeeany ia i?aenoaa? ioe?iee ia'?eoeaiiai noaio iaoe??ioa, iieaciee?a ooieoe?? ciai?oiueiai aeeoaiiy, uiaeaiiiai iii?oi?eiao i?eoeioiao??? ? aiae?co iio?aae a a?iioiaeeeyoaoi?ao. O?eaae?noue oa?ai?? ?AEN aoea no?iai ?iaeea?aeoaeueiith. E?ee i?ecia/aeeny a na?aaei?o aeicao (400-600 iea ia aeiao ca aaeioeaeii). E?euee?noue ?iaaeyoe?e ia aeiao ia ia?aaeuoaaea 3–4. Eiio?ieueio a?oio neeaee 18 ae?oae, ye? io?eioaaee eiia?iiaaio aacenio oa?ai?th, ui aeeth/aea ?ioae ? i?ieiiaiaai? i?aia?aoe oaio?e?io. Eiio?ieue ca ?acoeueoaoaie e?eoaaiiy cae?enithaaany ia i?aenoaa? ia??iaee/ii? ioe?iee ia'?eoeaiiai noaio oai?iai ? iieaciee?a ooieoe?? ciai?oiueiai aeeoaiiy. Iao? niinoa?aaeaiiy iieacaee, ui a on?o 20 ae?oae, ye? io?eioaaee oa?ai?th ?AEN, e?eoaaiiy aeyaeeiny aoaeoeaiei. Oaea c ia?oeo aei?a ee?i?/ii niinoa??aaeiny ciaioaiiy neiioii?a caoai?thaaiiy (i?enooie yaeooe, a?ae/oooy noeniaiiy o a?oaei?e ee?ooe?, eaoaeue) (?en. 4). ?en. 4. Aeeiai?ea ee?i?/ieo neiioii?a caoai?thaaiiy ia oii? i?ecia/aiiai e?eoaaiiy a ??cieo a?oiao ianoaaeaieo ae?oae *a?ac 10–14 aei?a o a?eueoino? ae?oae nooo?ai iie?ioeeeny iieacieee ooieoe?e ciai?oiueiai aeeoaiiy (?en. 5). ?en. 5. Aeeiai?ea ii?iae?caoe?? iieaciee?a i?eoeioiao??? ia oii? i?ecia/aiiai e?eoaaiiy a ??cieo a?oiao ianoaaeaieo ae?oae Ioaea, iaie aeiaaaeaia aeniea aoaeoeai?noue ?iaaeyoe?eieo noa?i?ae?a o e?eoaaii? aaaeei? oi?ie a?iio?aeueii? anoie iaa?oue o aeiaaeeo ?o i?ecia/aiiy o na?aaei?o aeicao. Canoinoaaiiy eiia?iiaaii? oa?ai?? c i?ecia/aiiyi na?aaei?o aeic ?AEN o ii?aeiaii? c i?ieiiaiaaieie 2-aaii?noaie (na?aaaio) aai i?ieiiaiaaieie i?aia?aoaie oaio?e?io aeicaieeei eiio?iethaaoe aaaeeo oi?io a?iio?aeueii? anoie o 85,0 % (17 c 20) aeiaaee?a aac i?aeaeuaiiy aeice ?iaaeyoe?eieo noa?i?ae?a. O a?eueoino? aeiaaee?a (15 ae?oae – 75,0 %) oa?ai?y ?AEN o?eaaea 2–4 i?n. O 5 (25,0 %) oai?eo aeiaaeiny i?iaeiaaeeoe e?eoaaiiy aei 6 i?n. – 1,5 ?ieo. Oaea oa?ai?y aeicaieeea eiio?iethaaoe anoio ? caiaeeea aei i?i?ioio iaaaciaeo aeieeiaiiy iia?/ieo aoaeo?a. Iao? aeine?aeaeaiiy iieacaee, ui a 5 % (2 c 40) i?aee?oe?a c aaaeeith oi?iith a?iio?aeueii? anoie aeiaaeiny canoinoaaoe eiia?iiaaio oa?ai?th, eiee ii?yae c ?AEN i?ecia/aee noa?i?aee nenoaiii? ae??, cie?aia, i?aaei?cieii. Oae? neooaoe?? aeieeee, eiee iaaaciaea iaeiio?ieueiaaiiai ia?aa?ao a?iio?aeueii? anoie cia/ii ia?aaeueea ?ecee aeieeiaiiy iia?/ieo aoaeo?a a?ae oa?ai?? noa?i?aeaie, ? ??aaiue ei?oecieo a e?ia? a i?aei?enooiiiio ia??iae? aoa ieae/ei a?ae a?eiaeo ii?iaoeaieo eieeaaiue. Ai?iiiaeueii-caeaaeia a?iio?aeueia anoia ae?aaiinoiaaia iaie eeoa a iaei??? ae?a/eiee-i?aee?oea (0,7 % a?ae 150 ae?oae) i?e ??ai? ei?oecieo a e?ia? a i?aei?enooiiiio ia??iae? 160 iiieue/e. Iaiaaath/enue ?ic?iaeoe aoaeoeaiee niin?a e?eoaaiiy i?enooio a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo, ie i?iaiae?coaaee ?acoeueoaoeai?noue o?ueio niinia?a aaaeaiiy oaeeo oai?eo. Aeine?aeaeaiiy i?iaiaeeeiny o o?ueio a?oiao ae?oae, ye? e?eoaaeeny a oiiaao niaoe?ae?ciaaiiai noaoe?iia?o (aea?aieia?/ia a?aeae?eaiiy EIAeEE). O ia?oeo aeaio a?oiao e?eoaaiiy ii/eiaee c i?ecia/aiiy ?iaaeyoe?eieo 2aaii?no?a (iae/ano?oa i?ecia/aany naeueaooaiie). Ca a?aenooiino? aoaeoo oai?ei ia?oi? a?oie (40 ae?oae) i?ecia/aee aetheiei?oeeinoa?i?aee ia?i?aeueii a aeiaia?e aeic? 0,25–1,0 ia/ea o ia?a?aooieo ia i?aaei?cieii. O ?ac? iiceoeaii? aeeiai?ee i?ioeano ia ae?oao aeiao ci?iaee i?aeuei? noa?i?aee, ia?aoiaey/e ia ?iaaeyoe?ei? a aeic? 400–800 iea ia aeiao ca aaeioeaeii. Oe? i?aia?aoe i?ecia/aeeny i?ioyaii 5–7 aei?a. Aioo??oiueiaaiia aaaaeaiiy aoo?e?io, aetheiei?oeeinoa?i?ae?a i?iaiaeeeiny eeoa a oiio aeiaaeeo, eiee aeacai? aeua caoiaee aoee iaaoaeoeaieie. Ae?oyi ae?oai? a?oie (45 oai?eo) o aeiaaeeo iaaoaeoeaiino? 2-aaii?no?a i?ecia/aee aioo??oiueiaaiia aaaaeaiiy aoo?e?io. sseui oaea oaeoeea e?eoaaiiy ia aeaaaea aoaeoo, i?e?aeioaaee aetheiei?oeeinoa?i?aee aioo??oiueiaaiii. O?aoth a?oio neeaee 20 ae?oae. E?eoaaiiy i?enooio a?iio?aeueii? anoie o oe?e a?oi? ii/eiaee c i?ecia/aiiy 2-aaii?no?a oa ?iaaeyoe?eieo noa?i?ae?a o aeic? 600–800 iea a aeiao ca aaeioeaeii. O ?ac? a?aenooiino? aoaeoo i?ecia/aee aetheiei?oeei?aee ia?i?aeueii. A iiaeaeueoiio e?eoaaeueia oaeoeea aoea oaeith ae, ye ? a ia?o?e a?oi?. I?iaaaeai? iaie aeine?aeaeaiiy aeiaaee, ui iaeaoaeoeai?oei ? ia?oee niin?a e?eoaaiiy, yeee ie ?aeiiaiaeo?ii aeey aeei?enoaiiy a oiiaao niaoe?ae?ciaaiiai noaoe?iia?o (?en. 6). – –     – ––– – ––– Aea/ath/e ?acoeueoaoe e?eoaaiiiy a?iio?aeueii? anoie a ae?oae i. Eueaiaa i?ioyaii 1994–1995 ??., ie anoaiiaeee, ui iecueea aoaeoeai?noue e?eoaaiiy cia/iith i??ith iia'ycaia c oei, ui oai?? ae?oe oa ?o aaoueee ia ciathoue iniaeeainoae oeueiai caoai?thaaiiy ? ia ?icoi?thoue iio?aao o?eaaei? oa?ai??, oiio /anoi ii?ooothoue ?aaeei ? i?aaeea e?eoaaiiy. Aeey oiai, uia ci?ieoe oeth neooaoe?th, ie i?aai?coaaee niaoe?aeueia iaa/aiiy, yea i?iaiaeeeiny a ??cieo oi?iao: 1) caiyooy a "anoia-oeie?"; 2) ?iaeea?aeoaeueia iaa/aiiy i?ae /an a?aea?aeoaaiiy e?ea?y; 3) eiioa?aioe?? aeey aaouee?a; 4) aeione niaoe?aeueieo aeiiii?aeieo iaoa??ae?a (a?ioo?e, i?iniaeoe, eieae oiui). Iniaeeaa cia/aiiy iaea ?iaioa "anoia-oeiee". I?ia?aia iaa/aiiy aeeth/aea 11 oaiaoe/ieo caiyoue, ye? noinoaaeeny i?e/ei aeieeiaiiy, iaoai?ci?a ?icaeoeo, ee?i?ee, ae?aaiinoeee, eiio?ieth ca ia?aa?aii oa aoaeoeai?noth e?eoaaiiy a?iio?aeueii? anoie oiui. Ca ia??iae i?iaaaeaiiy aeine?aeaeaiue a "anoia-oeie?" iaa/aeeny 87 aaouee?a ? 55 ae?oae. Caiyooy i?iaiaeeeeny o aeaeyae? eaeoe?e, aeeneon?e ? i?aeoe/ieo o?aioaaiue. Ia?oa caiyooy caaaeaee ii/eiaeiny c ei?ioeiai aieaoiiai iieooaaiiy, yea aeicaieyei iai ioe?ieoe ??aaiue ciaiue neooa/?a i?i anoio. Oaea aieaooaaiiy aeoaea /anoi aeyaeyei, ui ia?aaaaeia a?eueo?noue aaouee?a ? ae?oae ?ai?oa ia io?eioaaee iaeaaeii? ?ioi?iaoe?? i?i ee?i?/i? i?iyae e iniaeeaino? ia?aa?ao a?iio?aeueii? anoie, ia iaee iiiyooy i?i iiaeeea?noue eiio?ieth ooieoe?e ciai?oiueiai aeeoaiiy ca aeiiiiiaith i?eoeioiao?a, aaaaeaee iaaeinoaoiuei aoaeoeaiei iaaeeeaiaioicia e?eoaaiiy ? aeyaeyee aaeeea caiaiiei?iiy o?eaaeeie eo?naie oa?ai??. Ia?aaaaeia a?eueo?noue (62,9 %) aaouee?a aeciaee, ui aiie c iaaeia??ith noaaeeeny aei e?eoth/eo e?ea??a. Aaeeea oaaaa a ?iaio? "anoia-oeiee" i?eae?eyeany i?aeoe/iei o?aioaaiiyi, i?ae /an yeeo a?aei?aoeueiaoaaeeny iaai? iaae/ee, ui aeicaieythoue eiio?iethaaoe ia?aa?a oai?iae ? i?aaeeueii i?iaiaeeoe e?eoaaiiy. Oea, ia?o ca ana, noino?oueny iaieiae?iiy oaoi?eith i?iaaaeaiiy i?eoeioiao??? oa oi?ioaaiiy iaaee?a i?aaeeueiiai ei?enooaaiiy i?eno?iyie aeey ?iaaethaaiiy. O ?iaio? c ae?oueie iaeneiaeueii aeei?enoiaoaaeeny aa??aioe iaa/aiiy o aeaeyae? a?e. Oea aeicaieeei anoaiiaeoe ineoieia?/iee eiioaeo c ae?oueie, aiie ii/oaaee naaa c?o/ii, iaiaaaeeny io?eiaoe yeiaea?eueoa ciaiue i?i anoio oa aea?a?th. Aaaeeeaei aeiiiaiaiiyi aei iaa/aeueii? i?ia?aie aoei ii?aoethaaiiy ? ?iciianthaeaeaiiy niaoe?aeueieo iaoa??ae?a (iai'yoee, caa?iaiiy, iai/i? iin?aieee, ?ethno?aoe?? oiui), ye? ni?eyee e?auiio canai?iith iaoa??aeo. Nooo?aei aeaiaioii o ?iaio? aoei iaaiai?aiiy oa aiae?c ineoieia?/ieo i?iaeai, c yeeie iiaea cono??oeny oai?ee o uiaeaiiiio aeeoo? ? ye? ?iiae? ?noioii aieeaathoue ia aiioe?eio noa?o aeeoeie. Oaanue i?ioean iaa/aiiy a e?ioeaaiio ?acoeueoao? iiaeiai ni?eyoe oiio, uia i?ney cae?i/aiiy eiai eo?no ae?oe oa ?o aaoueee iiaee naiino?eii eiio?iethaaoe ia?aa?a oai?iae e aoaeoeai?noue e?eoaaiiy. C oe??th iaoith a/eee neooa/?a oeiee aanoe uiaeaiiee, a yeee caiineeeny iieacieee i?eoeioiao???, aeeiai?ea neiioii?a anoie (eaoaeue, caaeeoea, e?euee?noue i?enooi?a i?ioyaii aeiae, i?/i? ai?ciaee a?iioiniacio) ? e?ee, ui aeei?enoiaoaaeeny ca aeiao. Aa??aio uiaeaiieea naiieiio?ieth iiaeaiee ia ?en. 7. ?en. 7. Aa??aio uiaeaiieea naiieiio?ieth (i?enooi a?iio?aeueii? anoie –??cea cieaeaiiy IOA) A?ae?aco ae i?ney oeeeeo caiyoue ioe?ithaaeany aoaeoeai?noue iaa/aeueii? i?ia?aie, ii??aithth/e aieaoe, caiiaiai? neooa/aie oeiee aei ? i?ney cae?i/aiiy iaa/aiiy. Ia i?aenoaa? aieaoieo aeaieo onoaiiaeaii, ui 84,5 % neooa/?a i?ae /an iaa/aiiy nooo?ai ?icoe?eee nai? ciaiiy i?i nooi?noue a?iio?aeueii? anoie, c?icoi?ee iio?aao o?eaaeiai e?eoaaiiy ? naiieiio?ieth ca eiai aoaeoeai?noth. Aaaaoi??/i? niinoa?aaeaiiy i?ia?aeieo aea?aieia?a na?oo aeiaiaeyoue, ui ye?noue iaaee/ii? aeiiiiiae ? ??aaiue ciaiue iaoe??ioa i?i a?iio?aeueio anoio nooo?ai aieeaathoue ia ?? ia?aa?a ? i?iaiic. Iaie c?iaeaia ni?iaa c'ynoaaoe aieea iaaaaeaieo aeua oaeoi??a ia ia?aa?a a?iio?aeueii? anoie o i?aee?oe?a. Aeey aeine?aeaeaiiy aoei a?ae?a?aii 80 ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio, ye? ciaoiaeeeeny i?ae iino?eiei aeeiai?/iei niinoa?aaeaiiyi i?ioyaii ?ieo ? ia??iaee/ii i?ioiaeeee ianoaaeaiiy ia aac? Euea?anueei? i?nueei? aeeoy/i? ee?i?/ii? e?ea?i?. Ia?oo (iniiaio) a?oio neeaee 40 i?aee?oe?a, ye? io?eioaaee aaeaeaaoio oa?ai?th a?iio?aeueii? anoie, ui i?ecia/aeany c o?aooaaiiyi nooiaiy aaaeeino? caoai?thaaiiy. Iio??ai? aeey e?eoaaiiy ciaiiy ? iaaeee ae?oe oa ?o aaoueee iaaoee i?ae /an iaa/aiiy a "anoia-oeie?". Aeey ii??aiyiiy aoea noi?iiaaia eiio?ieueia a?oia c 40 oai?eo, ye? ia io?eioaaee aaeaeaaoio o?eaaeo oa?ai?th a?iio?aeueii? anoie. I?aee?oee oe??? a?oie oa ?o aaoueee /a?ac ??ci? ia'?eoeai? i?e/eie ia iaee aeinoaoiuei? ?ioi?iaoe?? i?i iniaeeaino? oeueiai caoai?thaaiiy, a oiio /anoi ii?oooaaee ?aaeei ? i?aaeea e?eoaaiiy. A iaio a?oiao ioe?ithaaee /anoioo caaino?aiue caoai?thaaiiy i?ioyaii ?ieo oa aeno?aieo caa?oaiue ca iaaee/iith aeiiiiiaith, /enei aini?oae?caoe?e, e?euee?noue i?iiouaieo aei?a iaa/aiiy o oeie?. E??i oeueiai, aea/aeenue e?ea?nuee? i?aia?aoe, ui aeei?enoiaoaaeeny aeey e?eoaaiiy a?iio?aeueii? anoie o eiaei?e ?c a?oi. O i?ioean? oeeo aeine?aeaeaiue ca?a?no?iaaii cieaeaiiy /enea aini?oae?caoe?e i?ioyaii ?ieo a iniiai?e a?oi? a 1,8 ?aca, /enea aeno?aieo caa?oaiue ca iaaee/iith aeiiiiiaith – o 2 ?ace, e?eueeino? caaino?aiue – a 1,5 ?aca. Aiaeii/an o eiio?ieuei?e a?oi? nooo?aiai cieaeaiiy oeeo iieaciee?a ia aeyaeaii. I?aee?oee iniiaii? a?oie aeinoia??ii ??aeoa ii??aiyii c eiio?ieueiith a?oiith i?iioneaee oe?euei? caiyooy (a?aeiia?aeii (29,8±6,5) aei? oa (58,5±8,9) aei?; ? < 0,05). Aiae?c /anoioe canoinoaaiiy ??cieo e?ea?nueeeo i?aia?ao?a aeey e?eoaaiiy a?iio?aeueii? anoie a eiaei?e ?c a?oi iieacaa, ui o ia?o?e (iniiai?e) a?oi? aeey o?eaaeiai e?eoaaiiy oe?oa aeei?enoiaoaaeeny ?iaaeyoe?ei? i?ioecaiaeuei? i?aia?aoe: ?ioae, oaeeaae, ei?oeeinoa?i?aee. Anoaiiaeaii, ui i?ney iaa/aiiy a "anoia-oeie?" cia/ii c?inea e?euee?noue oai?eo, ye? i?aaeeueii i?iaiaeeee ?iaaeyoe?eia aaaaeaiiy e?e?a, ui aacia?a/ii ni?eyei i?aeaeuaiith aoaeoeaiino? e?eoaaiiy. I?iaaaeai? iaie aeine?aeaeaiiy aeyaeee aieea ai?iiiaeueiiai noaoono a ia??iae noaoaaiai aeic??aaiiy ia ia?aa?a a?iio?aeueii? anoie o i?aee?oe?a ? iniaeeaino? ?? ee?i?ee caeaaeii a?ae noao?. Cai?iiiiiaaia a ?iaio? iaoaiaoe/ia iiaeaeue aeaea iiaeeea?noue i?iaiicoaaoe ?icaeoie aaaeei? oi?ie a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo ? a/anii i?aai?coaaoe i?io?eaeoe/i? caoiaee. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue ?ic?iaeaia i?ia?aia o?eaaeiai e?eoaaiiy c a?aooaaiiyi aaaeeino? ? ia??iaeo caoai?thaaiiy, yea ?acii c iaa/aiiyi a “anoia-oeie?” aeicaieeea aoaeoeaii eiio?iethaaoe ia?aa?a a?iio?aeueii? anoie ? cia/ii iie?ioeoe ye?noue aeeooy i?aee?oe?a. AENIIAEE 1. O ioaa?oaoiiio ia??iae? a?iio?aeueia anoia ci?ith? na?e ia?aa?a. O 49,1 % ae?a/aoie a?i iia??oo?oueny, aiaeii/an o a?eueoino? oeii/ee?a (84,2 %) niinoa??aa?oueny ee?i?/ia iie?ioaiiy. Iiceoeaia aeeiai?ea caoai?thaaiiy o oeii/ee?a, ui anooieee a ia??iae noaoaaiai aeic??aaiiy, iia’ycaia c i?aeaeuaiiyi oanoinoa?iio, yeee aeyaey? noi?aneaiee aieea ia ?ioiio a?aeiia?aeue. Iia??oaiiy ee?i?/iiai ia?aa?ao a ae?a/aoie coiiaeaia ai?iiiaeueiei aeenaaeainii, iniaeeai ae?aaeaiei o ia?aaeiaino?oaeueiiio ia??iae? ? iia’ycaiei c ii?ooaiiyi ni?aa?aeiioaiiy ano?iaaie/i?iaanoa?ii. Aenieee ai?no ano?iaai?a aeyaey? noeioeyoe?eiee aieea ia ?ioiio a?aeiia?aeue ? ?iaeoue i?aai?ci ae?a/eiee iniaeeai a?aceeaei aei ae?? o?eaa?ieo oaeoi??a. 2. O?eaa?ieie oaeoi?aie o ae?oae ioaa?oaoiiai a?eo iae/ano?oa aenooiathoue aea?aaie (70,0 %), A?A? (64,0 %), iaaei??i? o?ce/i? (66,6 %) e aiioe?ei? (10,0 %) iaaaioaaeaiiy, iaoaioaeoi?e (50,0 %), ai?iiiaeueiee aeenaaeain o ia?aaeiaino?oaeueiiio ia??iae? (o 85,9 % ae?a/aoie). 3. Iniaeeaino? ?ioiiiai noaoono o ae?oae ioaa?oaoiiai a?eo ni?eythoue c?inoaiith /anoioe aino?eo ?ani??aoi?ieo a??onieo ?ioaeoe?e, ui, a naith /a?ao, iaaaoeaii aieeaa? ia ia?aa?a a?iio?aeueii? anoie. 4. O ia?aaaaeii? a?eueoino? (62,6 %) i?aee?oe?a, oai?eo ia a?iio?aeueio anoio, niinoa??aathoueny ?noa?i?aei? ?ene oa?aeoa?o: aeaiiino?aoeai?noue o aeneiaethaaiiyo, ?ioiiaoe?yo ? iiaaae?ioe?, aaioeaio?eci; aiie aeoaea aiioe?ei? ? iaaecae/aeii a?aceea?. Oaea aiioe?eia eaa?euei?noue ni?ey? iia??oaiith ia?aa?ao oai?iae o ae?oae oe??? a?eiai? a?oie. 5. O ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio, /anoi aeyaeythoueny ?ioiieia?/i? ia?ea?e aoii??: i?aeaeuaiiy ?ioii?aaoeyoi?iiai ?iaeaeno (60,5 % aeiaaee?a), aenieee ??aaiue caaaeueiiai (62,0 %) ? niaoeeo?/iiai (87,6 %) IgE. 6. Ci?ie ai?iiiaeueiiai noaoono o ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?ii-o?aeueio anoio, caeaaeaoue a?ae aaaeeino? ia?aa?ao, o?eaaeino? ? ia??iaeo caoai?thaaiiy. O aeiaaeeo eaaeiai ? na?aaeiueiaaaeeiai ia?aa?ao oai?iae ai?iiiaeuei? c?ooaiiy ?a?no?othoueny eeoa o i?enooiiiio ia??iae? ? iiai?noth ii?iae?cothoueny o ia??iae? ?ai?n??. Ia oii? aaaeeiai ia?aa?ao oai?iae aeyaeythoueny ci?ie o i?aei?enooiiiio ia??iae?, ye? i?iyaeythoueny i?eai?/aiiyi ooieoe?? ei?e iaaeie?eiaeo caeic (cieaeaiiy ei?oecieo) o 2,1 % aeiaaee?a ? i?aeneeaiiyi ooieoe?iiaeueii? aeoeaiino? ueoiaeaeii? caeice (i?aeaeuaiiy oe?ieneio) o 12,6 % aeiaaee?a. 7. Aeey i?iaaaeaiiy aacenii? oa?ai?? a?iio?aeueii? anoie na?aaeiuei? aaaeeino? o ae?oae ioaa?oaoiiai a?eo ia?aaaao aeioe?eueii iaaeaaaoe i?ecia/aiith oaeeaaeo, yeee aeyaey?oueny aoaeoeaiei o 95,5 % aeiaaee?a. 8. Eiia?iiaaia oa?ai?y c i?ecia/aiiyi na?aaei?o aeic ?iaaeyoe?eieo aetheiei?oeeinoa?i?ae?a (400–600 iea ia aeiao ca aaeioeaeii) a ii?aeiaii? c i?ieiiaiaaieie 2-aaii?noaie (na?aaaio) aai i?ieiiaiaaieie i?aia?aoaie oaio?e?io aea? ciiao eiio?iethaaoe aaaeeo oi?io a?iio?aeueii? anoie o 85,0 % aeiaaee?a aac i?aeaeuaiiy aeice ?iaaeyoe?eieo noa?i?ae?a. 9. ??oaiiy i?i o?eaaeo oa?ai?th a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo nenoaiieie noa?i?aeaie iiaeiii i?eeiaoeny ia i?aenoaa? ioe?iee ee?i?/iiai ia?aa?ao oai?iae, aoaeoeaiino? oa?ai?? ?iaaeyoe?eieie noa?i?aeaie ? ?acoeueoao?a aeine?aeaeaiiy ooieoe?? ei?e iaaeie?eiaeo caeic. Cieaeaiiy ??aiy ei?oecieo a e?ia? a i?aei?enooiiiio ia??iae? ieae/a a?eiaeo ii?iaoeaieo eieeaaiue o?aaa ?icaeyaeaoe ye iieacaiiy aei oaeiai e?eoaaiiy. 10. Ai?iiiaeueia caeaaei?noue ?icaeaa?oueny o 0,7 % ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio, ui, i/aaeaeii, iia’ycaii, ianaiia?aae, c aaiaoe/ii aeaoa?i?iiaaiei cieaeaiiyi ee?oeiii? /ooeeaino? aei aetheiei?oeeinoa?i?ae?a ? ii?ooaiiyi ooieoe?? nenoaie a?iioaeaion-a?iio?c-iaaeie?eia? caeice. 11. E?eoaaiiy i?enooio a?iio?aeueii? anoie o i?aee?oe?a a oiiaao niaoe?ae?ciaaiiai noaoe?iia?o iiaeiii aeeth/aoe ye i?aia?aoe ae?oaiai ?yaeo nenoaii? aetheiei?oeei?aee ana?aaeeio c ?ic?aooieo 0,25–1,0 ia/ea ca i?aaei?cieiiii i?ioyaii 1–2 aei?a ? iaaeae? ?iaaeyoe?ei? noa?i?aee ei?ioeei eo?nii aei 5–7 aei?a. 12. Cai?iiiiiaaia i?ia?aia o?eaaei? oa?ai?? a?iio?aeueii? anoie oa iaa/aiiy i?aee?oe?a a "anoia-oeie?" aeicaieythoue cieceoe i?ioyaii ?ieo /enei aini?oae?caoe?e o 1,8 ?aca, /enei aeno?aieo caa?oaiue ca iaaee/iith aeiiiiiaith o 2 ?ace ? nooo?ai ciaioeoe e?euee?noue i?iiouaieo aei?a iaa/aiiy o oeie?. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeey ?iaeea?aeoaeueiiai i?iaiicoaaiiy ia?aa?ao a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo aeioe?eueii ei?enooaaoeny cai?iiiiiaaiith iaie ?aa?an?eiith iiaeaeeth ?icaeoeo aaaeei? oi?ie caoai?thaaiiy. 2. Aeey ioe?iee aaaeeino? ia?aa?ao a?iio?aeueii? anoie o i?aee?oe?a o?aaa ei?enooaaoeny ?ic?iaeaieie iaie /?oeeie e?eoa??yie, ye? aeeth/athoue /anoioo, ae?aaeai?noue ? o?eaae?noue i?enooi?a caoai?thaaiiy, ?aaeoe?th ia oa?ai?th a?iioiaeeeyoaoi?aie ? noai oai?iai a i?aei?enooiiiio ia??iae?. 3. I?ia?aia o?eaaeiai e?eoaaiiy a?iio?aeueii? anoie o i?aee?oe?a iiaeiia ?ic?iaeyoeny a?aeiia?aeii aei aaaeeino? caoai?thaaiiy ? aacoaaoeny ia i?ecia/aii? ?iaaeyoe?eieo i?ioecaiaeueieo i?aia?ao?a. I?aea?? iioeiaeueiiai aeicoaaiiy ? ?aaeeio i?eeiio oeeo iaaeeeaiaio?a iiaeiai i?iaiaeeoeny ia i?aenoaa? ioe?iee ia’?eoeaiiai noaio iaoe??ioa, iieaciee?a ooieoe?e i?aai?a ciai?oiueiai aeeoaiiy, uiaeaiiiai iii?oi?eiao i?eoeioiao??? ? aiae?co iio?aae o a?iioiaeeeyoaoi?ao. 4. Iieacaiiyi aei i?ecia/aiiy oaeeaaeo o?aaa aaaaeaoe na?aaeiueiaaaeeo oi?io caoai?thaaiiy. O e?eoaaii? aaaeei? oi?ie a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo ia?aaaao ne?ae iaaeaaaoe i?ecia/aiith na?aaei?o aeic ?iaaeyoe?eieo noa?i?ae?a (400–600 iea a aeiao ca aaeioeaeii), ?iiae? o ii?aeiaii? c i?ieiiaiaaieie 2aaii?noaie (na?aaaio) aai i?ieiiaiaaieie i?aia?aoaie oaio?e?io. 5. E?eoaaiiy i?enooio a?iio?aeueii? anoie o i?aee?oe?a ne?ae ii/eiaoe c i?ecia/aiiy ?iaaeyoe?eieo 2-aaii?no?a. I?aia?aoaie ae?oaiai ?yaeo a oiiaao niaoe?ae?ciaaiiai noaoe?iia?o iiaeii? aooe ia?i?aeuei? aetheiei?oeei?aee c ?ic?aooieo 0,25–1,0 ia/ea ca i?aaei?cieiiii, ye? aeathoue 1–2 aei?, ? iaaeae? ia?aoiaeyoue ia ?iaaeyoe?ei? noa?i?aee ei?ioeei eo?nii aei 5–7 aei?a. 6. Eiio?ieue ca ia?aa?aii oai?iae ? e?eoaaiiyi o?aaa cae?enithaaoe i?eoeioiao?ii c i?iaaaeaiiyi uiaeaiiiai iii?oi?eiao. 7. Aeey i?aeaeuaiiy aoaeoeaiino? e?eoaaiiy a?iio?aeueii? anoie i?e aea?aieia?/ieo a?aeae?eaiiyo iaiao?aeii noai?thaaoe “anoia-oeieo” ? aeei?enoiao-aaoe cai?iiiiiaaio iaie i?ia?aio iaa/aiiy i?aee?oe?a ? ?o aaouee?a. NIENIE IIOAE?EIAAIEO IAOEIAEO I?AOeUeCA OAIITH AeENA?OAOe?? 1. Aao E.A. A?iio?aeueia anoia o i?aee?oe?a. Euea?a: Aoean, 1998. – 176 n. 2. Aao E.A. sseui o Aaoi? aeeoeie a?iio?aeueia anoia. – Euea?a: Iiee?, 1998. – 36 n. 3. Aao E.A. No/ani? aniaeoe e?eoaaiiy a?iio?aeueii? anoie o ae?oae (iaeyae e?oa?aoo?e) // Iaaeeoeeia na?oo. – 1997. – O 2, ? 3. – N. 126–129. 4. Aao E.A. Aieea iaa/aiiy a "anoia-oeie?" ? nooi?i/anoi? oa?ai?? caoai?thaaiiy ia ia?aa?a a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo // ?ioiieia?y oa aea?aieia?y. – 1998. – ? 4. – N. 90–92. 5. Aao E.A. Ioe?iea ?ioiiiai noaoono o ae?oae ioaa?oaoiiai a?eo, oai?eo ia a?iio?aeueio anoio // Aenia?eiaioaeueia ? ee?i?/ia o?c?ieia?y ? a?io?i?y. – 1998. – ? 3/4. – N. 138–141. 6. Aao E.A. Aeai?eoi e?eoaaiiy i?enooio a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo // Oe?a?inueeee ioeueiiiieia?/iee aeo?iae. – 1999. – ? 1. – N. 44–46. 7. Aao E.A. Aecia/aiiy aea?aaiiniaoeeo?/ieo ?ioiiaeiaoe?i?a A a ae?aaiinoeoe? aoii?/ii? a?iio?aeueii? anoie o ae?oae // I?aeoe/ia iaaeeoeeia. – 1999. – ? 1/2. – N. 32–34. 8. Aao E.A. Aeina?ae i?aai?caoe?? ? ?iaioe anoia-oeiee o i. Eueaia? // A?niee i?iaeai a?ieia?? ? iaaeeoeeie. – 1999. – ? 6. – N. 115–118. 9. Aao E.A. Canoinoaaiiy ?iaaeyoe?eieo i?ioecaiaeueieo i?aia?ao?a aeey o?eaaeiai e?eoaaiiy ae?oae ioaa?oaoiiai a?eo c a?iio?aeueiith anoiith // Oe?a?inueeee iaaee/iee /aniien. – 1999. – ? 1/2. – N. 117–120. 10. Aao E.A. Noiooiy iaoieia?y o i?aee?oe?a, oai?eo ia a?iio?aeueio anoio // Aenia?eiaioaeueia ? ee?i?/ia o?c?ieia?y ? a?io?i?y. – 1999. – ? 1. – N. 81–84. 11. Aao E.A. Aiae?c ?ioi?iaoe?eii? oe?iiino? aeayeeo oaeoi??a o i?iaiicoaaii? aaaeei? oi?ie a?iio?aeueii? anoie o i?aee?oe?a// E?ea?nueea ni?aaa. – 1999. – ? 3. – N. 103–106. 12. Aao E.A. Aiae?c oaeoi??a, ui coiiaeththoue aeieeiaiiy a?iio?aeueii? anoie o ae?oae // Aeooaeuei? ieoaiiy oa?iaoeaaoe/ii? oa iaaee/ii? iaoee ? i?aeoeee: Ca. iaoe. noaoae, aei. 3. – Caii??aeaey, 1999. – N. 155–159. 13. Aao E.A. Aieea o?eaa?ieo oaeoi??a ia ia?aa?a a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo // I?aeoe/ia iaaeeoeeia. – 1999. – ? 3/4. – N. 17–21. 14. Aao E.A. Iniaeeaino? ee?i?ee a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo // Oe?a?inueeee ioeueiiiieia?/iee aeo?iae. – 1999. ? 3. N. 30–32. 15. Aao E.A. Aeei?enoaiiy aetheiei?oeeinoa?i?ae?a aeey aacenii? oa?ai?? a?iio?aeueii? anoie o i?aee?oe?a. – E?ee Oe?a?ie. – 1999. – ? 5. – N. 59–61. 16. Aao E.A., Eaneoey I.?. Aeooaeuei? aniaeoe ao?iiaoiaaiaco a?iio?aeueii? anoie o ae?oae // Oe?a?inueeee ioeueiiiieia?/i?e aeo?iae. – 1996. – ? 3. – N. 15–18. 17. Aoeae A.A., Aao E.A. I?iaeaia aeeoa?aioe?aeueii? ae?aaiinoeee ??cieo oi?i a?iio?aeueii? anoie o ae?oae // Acta medica Leopoliensia. – 1995. – ? 1. – N. 77–80. 18. Eaneoey I.?., Aao E.A. Iniaeeaino? oa?iaeioa?ai?? a?iio?aeueii? anoie o i?aee?oe?a // Oa?iaeieia?/iee a?niee. 1999. ? 3. N. 27–31. 19. Aao E.A., Aaa’ye E.?., Ieeeoei ss.I., Oaaaea ss.I. Iniaeeaino? aaiethoe?? aea?a?/iiai oiio o ae?oae // Aeooaeuei? i?iaeaie caoai?thaaiue aeeoy/iai a?eo. – Euea?a: Aneoeai, 1995. – N. 3. 20. Aao E.A., A?eeinueea I.A. Aea/aiiy ao?ieia?? aea?a?? c aeei?enoaiiyi ??cieo iaoiae?a oanooaaiiy in vitro // Aeooaeueiua aii?inu aea?iaoiaaia?ieiaee: Iao/ii-i?aeo. na. no. – Aeiai?iiao?iane; Oiaeueieoeeee, 1997. – N. 83. 21. Noaoiye I.A., ?o?iiaa N.A., Aao E.A. Aiae?c /anoioe ? no?oeoo?e aea?a?/ieo caoai?thaaiue aeeoaeueieo oeyo?a o ae?oae // Aeooaeuei? i?iaeaie caoai?thaaiue aeeoy/iai a?eo. – Euea?a: Aneoeai, 1995. – N. 28–30. 22. Iyiueeianueeee N.E., Aao E.A. Uia Aaoa aeeoeia aoea caei?iaith. – Euea?a, 1994. – 47 n. 23. Aao E.A. Oeyoe aaeineiiaeaiiy ?aaa?e?oaoe?eiiai e?eoaaiiy ae?oae aeioe?eueiiai a?eo, ye? oai??thoue ia a?iio?aeueio anoio // Oace ieaioio aeeoy/eo e?ea??a Oe?a?ie. – Oa?iii?eue, 1995. – N. 14. 24. Oea/aiei N.E., Oea/aiei ?.A., Aao E.A. Ae??oioa?ai?y aea?a?/ieo caoai?thaaiue o ae?oae // Oace aeiiia?aeae IX c’?caeo aeeoy/eo e?ea??a Oe?a?ie. – Iaeana, 1993. – N. 207–208. 25. Aao E.A. sseui o aeeoeie a?iio?aeueia anoia // Aioaea Aaeeoeueea. – 1999. – ? 10. – N. 12–13. 26. Besh L., Tkachenko S. Age peculiarities of atopic allergic background forming in children // 9th ?nternational Nongress of Immunology. – San-Francisco, California. – 1995. – S. 1175. 27. Besh L. Bronchial asthma in adolescents. Peculiarities of duration and treatment // The international Journal of Tuberculosis and Lung disease. – 1997. – ? 5, Supplement. – S. 33. Aiioaoe?y Aao E.A. A?iio?aeueia anoia o ae?oae ioaa?oaoiiai a?eo: iniaeeaino? iaoiaaiaco, ia?aa?ao ? e?eoaaiiy. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.27 – ioeueiiiieia?y. – ?inoeooo ooec?ao??? ? ioeueiiiieia?? ?i. O.A.ssiianueeiai AII Oe?a?ie, Ee?a, 1999. Aeena?oaoe?y i?enay/aia aeine?aeaeaiith iniaeeainoae iaoiaaiaco, ia?aa?ao ? e?eoaaiiy a?iio?aeueii? anoie o ae?oae ioaa?oaoiiai a?eo. Aecia/ai? i?e/eie, ui i?ecaiaeyoue aei ci?ie ia?aa?ao oeueiai caoai?thaaiiy a ia??iae noaoaaiai aeic??aaiiy, iieacai? a?aei?iiino? ee?i?ee o oeii/ee?a ? ae?a/aoie, coiiaeai? iniaeeainoyie ?o ai?iiiaeueiiai noaoono o ioaa?oao?. Cai?iiiiiaaiee niin?a ?iaeea?aeoaeueiiai i?iaiicoaaiiy ?icaeoeo aaaeei? oi?ie a?iio?aeueii? anoie o ae?oae oe??? a?eiai? a?oie. ?ic?iaeai? i?ia?aie e?eoaaiiy oa iaa/aiiy a “anoia-oeie?”, ye? aeicaieythoue aoaeoeaii eiio?iethaaoe ia?aa?a a?iio?aeueii? anoie ? cia/ii iie?ioothoue ye?noue aeeooy i?aee?oe?a. Eeth/ia? neiaa: a?iio?aeueia anoia, ioaa?oaoiee a?e, ai?iiiaeueiee noaoon, i?iaiicoaaiiy, i?ia?aie e?eoaaiiy, “anoia-oeiea”. Abstract Besh L.V. Bronchial asthma in children of pubertate age: peculiarities of pathogenesis, duration and treatment. – Manuscript. Thesis for degree of Doctor of Medicine by speciality 14.01.27 – pulmonology. – Institute of Phthisiology and Pulmonology named after F.G.Yanovsky of the Academy of Medicine of Ukraine, Kyiv, 1999. The dissertation is devoted to the examination of peculiarities of pathogenesis, duration and treatment of bronchial asthma in children of pubertate age. There were determined causes that lead to changes in duration of this disease during sexual maturation, and shown differences of clinical manifestations in boys and girls conditioned by peculiarities of their hormonal state in pubertate period. It was proposed the method of individual prognosis of development of severe forms of bronchial asthma in children of that age group. There were elaborated the treatment program and training in the "asthma-school" program that allow to control bronchial asthma duration effectively and considerably improve life quality in adolescents. Key words: bronchial asthma, pubertate age, hormonal state, prognosis, treatment program, "asthma-school". Aiiioaoeey Aao E.A. A?iioeaeueiay anoia o aeaoae ioaa?oaoiiai aic?anoa: iniaaiiinoe iaoiaaiaca, oa/aiey e ea/aiey. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.27 – ioeueiiiieiaey. – Einoeooo ooeceao?ee e ioeueiiiieiaee ei. O.A.ssiianeiai AII Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iinayuaia eco/aieth iniaaiiinoae iaoiaaiaca, eeeieee e ea/aiey a?iioeaeueiie anoiu o aeaoae ioaa?oaoiiai aic?anoa – iiae?inoeia. Ianeaaeiaaii 380 aeaoae, n?aaee eioi?uo 280 – aieueiua a?iioeaeueiie anoiie (150 – iiae?inoee a aic?anoa io 12 aei 15 eao, 130 – aeaoe io 4 aei 11 eao) e 100 –iiae?inoee eiio?ieueiie a?oiiu. Eniieueciaai eiiieaeniue iiaeoiae a i?iaaaeaiee enneaaeiaaiee. Ia?yaeo n ouaoaeueiui eeeie/aneei ianeaaeiaaieai, eioi?ia aeeth/aei ioeaieo oece/aneiai e iieiaiai ?acaeoey aeaoae, i?iaiaeeeinue eco/aiea ooieoeee i?aaiia aiaoiaai aeuoaiey (nie?i-, iiaaiioaoi-, ieeoeioiao?ey), ii?aaeaeyeenue eiioiieiae/aneea iieacaoaee a e?iae e ooieoeeiiaeueiia ninoiyiea yiaeie?eiiie nenoaiu, i?iaiaeeeanue niaoeeoe/aneay aeea?aiaeeaaiinoeea. Enneaaeiaaiey iieacaee, /oi oa/aiea a?iioeaeueiie anoiu a ioaa?oaoiii ia?eiaea eciaiyaony. O 49,1 % aeaai/ae ioia/aaony aai oooaeoaiea, a oi aea a?aiy o aieueoeinoaa iaeue/eeia (84,2 %) iaaethaeaaony eeeie/aneia oeo/oaiea. Enoiaey ec ?acoeueoaoia enneaaeiaaiey, yoe ioee/ey a oa/aiee caaieaaaiey iiaeii a cia/eoaeueiie ia?a iauynieoue iieiauie iniaaiiinoyie ai?iiiaeueiuo eciaiaiee a ioaa?oaoiii aic?anoa. Iieiaeeoaeueiay aeeiaieea caaieaaaiey o iaeue/eeia, anooieaoeo a ia?eiae iieiaiai nic?aaaiey, naycaia n iiauoaieai o?iaiy oanoinoa?iia. Oooaeoaiea eeeie/aneiai oa/aiey o aeaai/ae iaoneiaeaii ai?iiiaeueiui aeenaaeainii, iaeaieaa au?aaeaiiui a i?aaeiaino?oaeueiii ia?eiaea, naycaiiui n iiauoaieai niaea?aeaiey yno?iaaiia ai aoi?ie oaca iaino?oaeueiiai oeeeea e ia?ooaieai niioiioaiey yno?iaaiu/i?iaanoa?ii. Eco/aiea o?iaiy ai?iiiia a e?iae e eo iaoaaieeoia a ii/a aeaei aiciiaeiinoue onoaiiaeoue o aeaoae ioaa?oaoiiai aic?anoa, aieueiuo a?iioeaeueiie anoiie, eciaiaiey ai?iiiaeueiiai noaoona, eioi?ua caaenyo io oyaeanoe oa/aiey e ia?eiaea caaieaaaiey. A neo/aa eaaeiai e n?aaeiaoyaeaeiai oa/aiey aieacie ai?iiiaeueiua ia?ooaiey ?aaeno?e?othony oieueei a i?enooiiii ia?eiaea e iaania/eaatho ioiineoaeueii iioeiaeueioth aaeaioaoeeth n iieiui ooieoeeiiaeueiui ainnoaiiaeaieai a ia?eiaea ?aiennee. Ia oiia oyaeaeiai oa/aiey caaieaaaiey ii?aaeaeythony eciaiaiey a iaaei?enooiiii ia?eiaea, eioi?ua i?iyaeythony a 2,1 % neo/aaa oaiaoaieai ooieoeee ei?u iaaeii/a/ieeia (nieaeaiea ei?oeciea) e a 12,6 % neo/aaa oneeaieai ooieoeeiiaeueiie aeoeaiinoe ueoiaeaeiie aeaeacu (iiauoaiea oe?ieneia). Ia iniiaaiee oaeoaeaiiiai aiaeeca i?e/eiiuo e niinianoaothueo oaeoi?ia ?acaeoey a?iioeaeueiie anoiu, eco/aiey iniaaiiinoae iaoiaaiaca, eeeieee e ea/aiey yoiai caaieaaaiey ?ac?aaioaia i?iaiinoe/aneay iaoaiaoe/aneay iiaeaeue ?acaeoey oyaeaeie oi?iu a?iioeaeueiie anoiu o iiae?inoeia, eioi?ay iiaeao auoue eniieueciaaia a i?aeoe/aneie iaaeeoeeia. ?ac?aaioaiu iieacaiey e aeeeoaeueiiio iacia/aieth eiie?aoiuo i?ioeaiainiaeeoaeueiuo i?aia?aoia aeey ea/aiey a?iioeaeueiie anoiu o iiae?inoeia. Aiaeec ?acoeueoaoia eniieueciaaiey oaeeaaea iieacae, /oi yoio i?aia?ao yooaeoeaai a 95,5 % neo/aaa n?aaeiaoyaeaeiai oa/aiey a?iioeaeueiie anoiu. O iiae?inoeia n oyaeaeui oa/aieai caaieaaaiey eco/aeanue yooaeoeaiinoue ea/aiey aetheiei?oeeinoa?ieaeaie. I?iaaaeaiiua enneaaeiaaiey iieacaee, /oi eiiaeie?iaaiiay oa?aiey n iacia/aieai n?aaeieo aeic eiaaeyoeeiiiuo aetheiei?oeeinoa?ieaeia (400-600 iea a nooee ii aaeioeaeo) a eiiieaena n i?ieiiae?iaaiiuie 2-aaiienoaie (na?aaaio) eee i?ieiiae?iaaiiuie i?aia?aoaie oaioeeeeia aeaao aiciiaeiinoue eiio?iee?iaaoue oyaeaeoth oi?io a?iioeaeueiie anoiu o 85,0 % neo/aaa aac iiauoaiey aeicu eiaaeyoeeiiiuo noa?ieaeia. ?aoaiea i aeeeoaeueiii iacia/aiee nenoaiiuo noa?ieaeia iiae?inoeai, aieueiui a?iioeaeueiie anoiie, neaaeoao i?eieiaoue ia iniiaaiee ioeaiee eeeie/aneiai oa/aiey aieacie, yooaeoeaiinoe oa?aiee eiaaeyoeeiiiuie noa?ieaeaie e ?acoeueoaoia enneaaeiaaiey ooieoeee ei?u iaaeii/a/ieeia. Nieaeaiea o?iaiy ei?oeciea a e?iae a iaaei?enooiiii ia?eiaea ieaea aic?anoiuo ii?iaoeaiuo eieaaaiee yaeyaony iieacaieai e iacia/aieth oaeiai ea/aiey. Enneaaeiaaiey iieacaee, /oi ai?iiiaeueiay caaeneiinoue ?acaeaaaony o 0,7 % aeaoae ioaa?oaoiiai aic?anoa, aieueiuo a?iioeaeueiie anoiie, /oi, aa?iyoii, naycaii, a ia?aoth i/a?aaeue, n aaiaoe/anee aeaoa?ieie?iaaiiui nieaeaieai eeaoi/iie /oanoaeoaeueiinoe e aetheiei?oeeinoa?ieaeai e ia?ooaieai ooieoeee nenoaiu aeiioaeaion–aeiioec–iaaeii/a/ieee. A ?aaioa i?aaei?eiyoa iiiuoea ?ac?aaioee aeai?eoia ea/aiey i?enooia a?iioeaeueiie anou o aeaoae ioaa?oaoiiai aic?anoa ia iniiaaiee aiaeeca yooaeoeaiinoe o?ao niiniaia aaaeaiey oaeeo aieueiuo. Onoaiiaeaii, /oi ea/aiea i?enooiia a?iioeaeueiie anoiu o iiae?inoeia a oneiaeyo niaoeeaeece?iaaiiiai noaoeeiia?a aeieaeii aeeth/aoue a ea/anoaa i?aia?aoia aoi?iai ?yaea nenoaiiua aetheiei?oeeinoa?ieaeu aioo?ue ec ?an/aoa 0,25–1,0 ia/ea ii i?aaeiecieiio ia i?ioyaeaiee 1–2 aeiae n iineaaeothuei ia?aoiaeii ia ei?ioeee eo?n eiaaeyoeeiiiuo noa?ieaeia (aei 5–7 aeiae). I?iaaaeaiiua enneaaeiaaiey iieacaee, /oi iiauoaieth yooaeoeaiinoe ea/aiey niinianoaoao iao/aiea iiae?inoeia e eo ?iaeeoaeae a "anoia-oeiea". I?aaeeiaeaiiay a ?aaioa i?ia?aiia aeeeoaeueiie oa?aiee a?iioeaeueiie anoiu e iao/aiey a "anoia-oeiea" nieaeatho ia i?ioyaeaiee aiaea /enei ainieoaeecaoeee a 1,8 ?aca, /enei yeno?aiiuo ia?auaiee ca iaaeeoeeineie iiiiuueth a 2 ?aca e nouanoaaiii oiaiueoatho eiee/anoai i?iiouaiiuo aeiae iao/aiey a oeiea. Eeth/aaua neiaa: a?iioeaeueiay anoia, ioaa?oaoiue aic?ano, ai?iiiaeueiue noaoon, i?iaiice?iaaiea, i?ia?aiiu ea/aiey, “anoia-oeiea”.

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