2

I?i?noa?noai aa?ii?iieneiaiai eiiieaeno Oe?a?ie

A?eioea?e?anueeee aea?aeaaiee aa?a?iee oi?aa?neoao

Cei/aanueeee Ieoaeei Aieiaeeie?iae/

OAeE 636.2.035/.087.7]:573.6

A?ioaoiieia?y iaea?aeaiiy ? canoinoaaiiy aeciaaiii? ?iiia?e?ciaaii?
aetheiai?eace o aiae?ae? iieiaeiyeo aaeeei? ?iaaoi? ooaeiae

03.00.20 – a?ioaoiieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa n?euenueeiainiiaea?nueeeo iaoe

A?ea Oea?eaa – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Iaoeiai-aeine?aeiiio ?inoeooo? aeieia?? ?
a?ioaoiieia?? o oaa?eiieoeoa? A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai
oi?aa?neoaoo oa ?inoeooo? ?icaaaeaiiy ? aaiaoeee

oaa?ei OAAI

Iaoeiaee ea??aiee: — aeieoi? a?ieia?/ieo iaoe, i?ioani?,

/eai-ei?aniiiaeaio OAAI, caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie
Aa?aneiaiei A?eoi? A?eai?iae/, A?eioea?e?anueeee aea?aeaaiee aa?a?iee
oi?aa?neoao, i?i?aeoi? c iaa/aeueii? ?iaioe

Io?oe?ei? iiiiaioe: — aeieoi? aaoa?eia?ieo iaoe, i?ioani? I?e?oaiei
Aiaoie?e Iaoiae?eiae/, A?eioea?e?anueeee aea?aeaaiee aa?a?iee
oi?aa?neoao, caa?aeoaa/ eaoaae?e ciia?a??ie oa iniia aaoa?eia???

— aeieoi? n?euenueeiainiiaea?nueeeo iaoe, i?ioani? Iaco?aiei Ieeiea
Ieaenaiae?iae/, A?iieoeueeee aea?aeaaiee n?eueneiainiiaea?nueeee
?inoeooo, caa?aeoaa/ eaoaae?e oaoiieia?? ae?iaieoeoaa i?iaeoeo?a
oaa?eiieoeoaa

I?ia?aeia onoaiiaa: Aea?aeaaiee iaoeiai-aeine?aeiee ?inoeooo
aaoa?eia?ieo i?aia?ao?a ? ei?iiaeo aeiaaaie,

i. Euea?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 27 ” ea?oiy 1999 ?ieo i 14-00 aiae.
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae27.821.01 a
A?eioea?e?anueeiio aea?aeaaiiio aa?a?iiio oi?aa?neoao? ca aae?anith:
256400, i.A?ea Oea?eaa, Niai?ia ieiua 8/1, a aoae. 11.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? A?eioea?e?anueeiai
aea?aeaaiiai aa?a?iiai oi?aa?neoaoo.

Aaoi?aoa?ao ?ic?neaiee “ 26 ” aa?aciy 1999 ?ieo.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

eaiaeeaeao a?ieia?/ieo iaoe
?iciooi?e I.?.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. O eiiieaen? caoiae?a ii ae?iaieoeoao
eiieo?aioini?iiiaeii? i?iaeoeoe?? oaa?eiieoeoaa aaaeeeaith eaieith ?
i?aeaeuaiiy aoaeoeaiino? aeei?enoaiiy iiaeeaieo ?a/iaei ei?i?a. O
i?aeoeoe? aiae?ae? c oe??th iaoith aeei?enoiaothoue i?ia?aeuei?
?a/iaeie, oa?iaioi? i?aia?aoe oa ?io? a?ieia?/ii aeoeai? niieoee, ye?
?ioaineo?eothoue i?ioeane ?icuaieaiiy iiaeeaieo ?a/iaei ?aoe?iio o
oeoieiai-eeoeiaiio o?aeo?, i?aeaeuothoue ?o ia?ao?aai?noue oa canai?iiy
i?iaeoeo?a a?ae?ie?co ? ni?eythoue i?aeaeuaiith i?iaeoeoeaiino? oaa?ei
(Aiaaeaiia A.I., 1981; Aa?aneiaiei A.A., 1981; A?aaiaainueeee ?.?.,
Eaea/ithe A.?., 1984; Aaa?e/oe I.A., TH?/aiei O.O., Eieiae?e O.?. ? ?i.,
1987; Iaco?aiei I.I., 1987; Iaeueiee ?.?., I?e?oaiei A.I., 1988;
*oia/aiei A.TH. oa ?i., 1989; E?aaoe?a ?.?., 1992; Canooa O.A., Eoeee
I.O., 1993, 1997). Iaeiae aeina?ae aeei?enoaiiy oa?iaioieo i?aia?ao?a o
oaa?eiieoeoa? na?ae/eoue i?i aaeee? ?ica?aeiino? uiaei ?o aoaeoeaiino?.
Iiynith?oueny oea cia/iith i??ith oei, ui o oeoieiai-eeoeiaiio o?aeo?
aeciaaii? oa?iaioe caciathoue ?oeioaaiiy /a?ac iaa?aeiia?aei?noue ?I
ai?noeiiai iioeioio ae?? oa?iaio?a, a oaeiae /a?ac aieea ?ia?a?oi??a oa
i?ioaac.

Aeey i?aeaeuaiiy no?eeino? oa?iaio?a aei aieeao ??cieo oaeoi??a
aeei?enoiaothoue iaoiae ?oiuei? ?iiia?e?caoe??, oiaoi ca’ycoaaiiy
oa?iaio?a c aiaeiia?ic/eiiei iin??i. ?iiia?e?caoe?y aeicaiey?
oe?eani?yiiaaii ci?ithaaoe aeanoeaino? oa?iaio?a, o oiio /ene? ?o
niaoeeo?/i?noue, caeaaei?noue aeoeaiino? a?ae ?I na?aaeiaeua ?, ui
iniaeeai aaaeeeai, eiai noaa?euei?noue uiaei ??cieo aeaiaoo?oth/eo
aieea?a na?aaeiaeua (Aa?ac?i ?.A. oa ?i., 1987, 1988, 1990; O?eaai I.,
1984; Aeae. Aoaeai?ae, 1988).

Oeyoii ?iiia?e?caoe?? ? iiaeeo?eaoe?? iaea?aeaii iia? oi?ie i?aia?ao?a
a?ieia?/ii aeoeaieo ?a/iaei c i?ieiiaiaaiith ae??th, aea iaeaea an? aiie
aeei?enoiaothoueny aeey iio?aa ae?iaieoeoaa a?ioaoiieia?/ii?
i?iaeoeoe??. Eeoa iacia/ia e?euee?noue aeine?aeaeaiue ni?yiiaaia ia
noai?aiiy i?ieiiaiaaieo oi?i aeciaaiieo oa?iaio?a, aaeaioiaaieo aei
iio?aa oaa?eiieoeoaa (Aa?aneiaiei A.A. oa ?i. 1991; Coaaoeue I.A.,
Aa?aneiaiei A.A. oa ?i., 1998).

C iaeyaeo ia aeuaneacaia, ia?niaeoeaiei iai?yiii aeine?aeaeaiue ?
?ic?iaea niinia?a i?aeaeuaiiy noaa?eueiino? aeciaaiieo oa?iaioieo
i?aia?ao?a, ye? aeei?enoiaothoueny o oaa?eiieoeoa?, oa iaoeiaeo iniia
canoinoaaiiy ?oi?o ?iiia?e?ciaaieo oi?i o aiae?ae? oaa?ei.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa ? o?aaiaioii iaoeiaeo aeine?aeaeaiue oaie 082 “Aeine?aeeoe
aeeiai?eo aaaeeeo iaoae?a a eaieao oa?/iaiai eaioethaa, ai?iaaaeeoe
?aeiiaiaeaoe?? ii iaea?aeaiith aeieia?/ii /enoi? i?iaeoeoe??, a oaeiae
aea/eoe o?i?ei-a?ieia?/i? iniiae ? ?ic?iaeoe iaoiaee eiino?othaaiiy
i?aia?ao?a a?ieia?/ii aeoeaieo ?a/iaei”, ? aea?ae?a?no?aoe??
0193U042483, ui aeeiio?oueny ca caiiaeaiiyi Oi?aae?iiy eii?aeeiaoe??,
inai?iiy IOI oa ca’yce?a c OAAI I?i?noa?noaa aa?ii?iieneiaiai eiiieaeno
Oe?a?ie Iaoeiai-aeine?aeiei ?inoeoooii aeieia?? ? a?ioaoiieia?? o
oaa?eiieoeoa? A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo
oa ?icae?eii oaie 03.09 “?ic?iaeoe aoaeoeaio nenoaio
a?aeoai?aiiy, ?ioaineaiiai ae?iuoaaiiy oa i?aeaioiaee aei eaeoaoe??
aenieii?iaeoeoeaieo ei??a”, yea aeeiioaaeanue a ?inoeooo? ?icaaaeaiiy ?
aaiaoeee oaa?ei OAAI ai?iaeiaae 1993-1995 ?ie?a.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith aeaii? ?iaioe ? ?ic?iaea niiniao
i?aeaeuaiiy noaa?eueiino? aeciaaiiiai oa?iaioiiai i?aia?aoo
aetheiai?eace A20o, yea aeei?enoiao?oueny o oaa?eiieoeoa? aeey
i?aeaeuaiiy i?iaeoeoeaiino?, oeyoii ?? ?iiia?e?caoe?? ia i?ia?aeueieo
iin?yo — oeaie?o? oa aa?inee?, a oaeiae aea/aiiy aoaeoeaiino?
canoinoaaiiy iaea?aeaiiai a?ieaoae?caoi?a i?ieiiaiaaii? ae?? o aiae?ae?
iieiaeiyeo aaeeei? ?iaaoi? ooaeiae.

Aeey aeinyaiaiiy oe??? iaoe aoee aecia/ai? oae? caaaeaiiy:

· aena?oeeoe oai?aoe/i? i?eioeeie iaea?aeaiiy a?ieaoae?caoi??a
i?ieiiaiaaii? ae?? oeyoii ?iiia?e?caoe?? ? iiaeeo?eaoe?? a?ieia?/ii
aeoeaieo ?a/iaei;

· aeyaeoe aieea ??cieo oaeoi??a (i?e?iaee iin?y, ?I ? ?iiii? neee
?ic/eio, eiioeaio?aoe?? oa?iaioo, neeaaeo ??aeei? oace) ia i?ioean
?iiia?e?caoe??;

· aecia/eoe iioeiaeuei? ia?aiao?e ?iiia?e?caoe?? aetheiai?eace A20o ia
??cieo iin?yo (oeaie?o?, aa?inee?);

· aea/eoe no?ee?noue ?iiia?e?ciaaiiai ia oeeo iin?yo oa?iaioo in vitro
i?e ??cieo cia/aiiyo ?I na?aaeiaeua, ii??aiyii c eiai iaoeaiith oi?iith;

· c?iaeoe ii??aiyeueio oa?aeoa?enoeeo aeanoeainoae iaoeaiiai oa
?iiia?e?ciaaiiai ia ??cieo iin?yo oa?iaioo a oiiaao in vitro;

· aeine?aeeoe ?ioaineai?noue ? ni?yiiaai?noue a?ineioaoe/ieo i?ioean?a o
i?aai?ci? oaeyo i?ae aieeaii ?iiia?e?ciaaii? aetheiai?eace;

· aea/eoe aieea iaea?aeaiiai iiaeeo?eiaaiiai i?aia?aoo ai?eie?oe/ii?
ae?? ia i?iaeoeoeai?noue iieiaeiyeo aaeeei? ?iaaoi? ooaeiae;

· ia iniia? iaea?aeaieo ?acoeueoao?a c?iaeoe aeniiaee ? aeaoe
i?iiiceoe?? ae?iaieoeoao.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa oeyoii ?iiia?e?caoe??
aetheiai?eace A20o ia iin?? aa?inee? iaea?aeaii iiaeeo?eiaaiee
aeciaaiiee oa?iaioiee i?aia?ao i?ieiiaiaaii? ae?? oa aecia/aii
iioeiaeuei? oiiae aeey aaeni?aoe?? oa?iaioo ia iao?eoe?.

I?iaaaeaii aaeineiiaeaiiy oaoiieia?? ?iiia?e?caoe?? aetheiai?eace A20o
ia iin?? oeaie?o? oeyoii cai?ie a ??aee?e oac? aoeaoaoiiai aooa?iiai
?ic/eio c ?I 5,0 ia aeenoeeueiaaio aiaeo, ui i?aeaeuo? oaoiieia?/i?noue
? caeaoaaeth? i?ioean iaea?aeaiiy a?ieaoae?caoi?a aac nooo?aiai
cieaeaiiy eiai noaa?eueiino? ? eaoae?oe/ii? aeoeaiino?.

Aeiaaaeaii, ui ?iiia?e?ciaaia oi?ia oa?iaioo caa??aa? aeineoue aenieo
oa?iaioaoeaio aeoeai?noue ? ? a?eueo no?eeith aei aeaiaoo?oth/iai aieeao
?I na?aaeiaeua. Oea caaacia/o? a?ae?ie?oe/io caeaoi?noue a?ieaoae?caoi?a
ia i?ioyc? onueiai oeoieiai-eeoeiaiai o?aeoo oaa?ei.

Aia?oa i?iaaaeaii aea/aiiy aoaeoeaiino? aeei?enoaiiy ?iiia?e?ciaaii?
aetheiai?eace ia iieiaeiyeo aaeeei? ?iaaoi? ooaeiae. Aeyaeaii, ui
canoinoaaiiy iiaeeo?eiaaiiai oa?iaioo ni?ey? ?ioaineo?eaoe?? iai?iieo
i?ioean?a a i?aai?ci? oaa?ei ? i?aeaeuo? ?oith i?iaeoeoeai?noue.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. I?iaaaeaieie
aeine?aeaeaiiyie aeiaaaeaia iiaeeea?noue ? aeioe?euei?noue aeei?enoaiiy
a?ioaoiieia?/ieo i?eeii?a o ae??oaii? i?aeoe/ieo caaaeaiue
oaa?eiieoeoaa.

?ic?iaeaii i?inoee, aeinooiiee ? aeaoaaee niin?a iiaeeo?eaoe??
aeciaaiiiai oa?iaioiiai i?aia?aoo ai?eie?oe/iiai niaeo?o ae??, yeee
canoiniao?oueny o oaa?eiieoeoa?.

Cai?ia aoeaoaoiiai aooa?iiai ?ic/eio c ?I 5,0 ia aeenoeeueiaaio aiaeo o
??aee?e oac? i?e i?iaaaeaii? ?iiia?e?caoe?? iie?auo? oaoiieia?/i?noue ?
caeaoaaeth? i?ioean iaea?aeaiiy a?ieaoae?caoi?a.

Ioe?iea i?iaeoeoeaii? ae?? iaea?aeaiiai i?aia?aoo a
iaoeiai-ainiiaea?nueeeo aeine?aeao aeicaieeea ?aeiiaiaeoaaoe
iiaeeo?eiaaio aetheiai?eaco A20o ye aoaeoeaio aeii?oeo aei ?aoe?ii?a
iieiaeiyeo aaeeei? ?iaaoi? ooaeiae c iaoith i?aeaeuaiiy i?iaeoeoeaiino?
oaa?ei.

Ia iniia? iaea?aeaieo ?acoeueoao?a ?ic?iaeaii ?aeiiaiaeaoe?? uiaei
iaea?aeaiiy oa aeei?enoaiiy aeciaaiii? aetheiai?eace o aiae?ae?
iieiaeiyeo aaeeei? ?iaaoi? ooaeiae oa iaoiaee/i? aeac?aee aeey
i?iaaaeaiiy eaai?aoi?ii-i?aeoe/ieo caiyoue c a?ioaoiieia??
?iiia?e?caoe?? oa?iaio?a aeey nooaeaio?a cii?iaeaia?iiai oaeoeueoaoo ?
oaeoeueoaoo aaoa?eia?ii? iaaeeoeeie.

Iniaenoee aianie caeiaoaa/a. O/anoue caeiaoaa/a a io?eiaii? iaoeiaeo
?acoeueoao?a, ye? iieeaaeaii a iniiao aeena?oaoe??, noaiiaeoue 80%.
Aaoi?ii iniaenoi aeeiiai? aenia?eiaioaeuei? aeine?aeaeaiiy in vitro ii
iaea?aeaiith a?ieaoae?caoi?a i?ieiiaiaaii? ae?? c aeei?enoaiiyi
aeciaaiiiai oa?iaioiiai i?aia?aoo aetheiai?eace A20o, a oaeiae
cae?eniaii i?aai?caoe?th ? i?iaaaeaiiy iaoeiai-ainiiaea?nueeeo
aeine?ae?a ia iieiaeiyeo aaeeei? ?iaaoi? ooaeiae, a?io?i?/i?
aeine?aeaeaiiy e?ia?, noaoenoe/io ia?iaeo oa aiae?c iaea?aeaieo
?acoeueoao?a, iaa?oiooaaiiy ? aeniiaee. Iaoeiaa a?iioaca i?i i?aeaeuaiiy
noaa?eueiino? aeciaaiieo oa?iaioieo i?aia?ao?a oeyoii ?o ?iiia?e?caoe??
? iiaeeea?noue aeei?enoaiiy io?eiaieo a?ieaoae?caoi??a i?e ?ioaineaiiio
ae?iuoaaii? iieiaeiyeo aaeeei? ?iaaoi? ooaeiae c iaoith iiai?oi?
?aae?caoe?? aaiaoe/iiai iioaioe?aeo ii??ae iaeaaeeoue iaoeiaiio
ea??aieeo /eai-ei?. OAAI Aa?aneiaieo A.A.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ia can?aeaiiyo a/aii? ?aaee cii?iaeaia?iiai oaeoeueoaoo
? oaeoeueoaoo aaoa?eia?ii? iaaeeoeeie A?eioea?e?anueeiai aea?aeaaiiai
aa?a?iiai oi?aa?neoaoo (1992-1997) oa ?inoeoooo ?icaaaeaiiy ? aaiaoeee
oaa?ei OAAI (1993-1995), naeoe?? aaoa?eia?ii? iaaeeoeeie
Iaoeiai-oaoi?/ii? ?aaee I?iaa?ii?iio Oe?a?ie (1994-1997),
?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “I?iaeaie i?aeaeuaiiy
i?iaeoeoeaiino? oaa?ei oa aoaeoeaiino? ?o e?eoaaiiy” (i.
Aei?i?iiao?ianuee, 1994), iaoeiai-i?aeoe/i?e eiioa?aioe?? “A/ai?
aea?aeaaiiai n?euenueeiainiiaea?nueeiai ?inoeoooo — ae?iaieoeoao” (i.
A?ea Oea?eaa, 1994), Anaoe?a?inuee?e eiioa?aioe?? c o?c?ieia?? ?
a?io?i?? oaa?ei (i. Euea?a, 1994), a oaeiae ia ni?eueiiio ?icoe?aiiio
can?aeaii? eaoaae? aiae?ae? n?euenueeiainiiaea?nueeeo oaa?ei ?
a?ioaoiieia??, aiaoii?? ? a?noieia??, ciia?a??ie oa iniia aaoa?eia???,
i?e?ia?ieia?? ? a??onieia??, o?c?ieia?? ? iaoo?c?ieia??, i?aai?/ii? ?
a?ieia?/ii? o?i??, o??o?a??, ?icaaaeaiiy ? aaiaoeee oaa?ei
A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo 3 /a?aiy 1998
?ieo.

Iaea?aeai? ?acoeueoaoe aeei?enoiaothoueny o iaa/aeueiiio i?ioean? i?e
aea/aii? a?ioaoiieia?? ia cii?iaeaia?iiio ? oaeoeueoao? aaoa?eia?ii?
iaaeeoeeie A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo.

Ioae?eaoe??. Iniiai? iieiaeaiiy ? ?acoeueoaoe aeine?aeaeaiue
iioae?eiaai? o i’yoe ae?oeiaaieo i?aoeyo o aeaeyae? iaoeiaeo noaoae oa
?aeiiaiaeaoe?yo ae?iaieoeoao.

No?oeoo?a oa ia’?i ?iaioe. Aeena?oaoe?y neeaaea?oueny ?c anooio,
iaeyaeo e?oa?aoo?e, iieno iaoa??ae?a ? iaoiae?a aeine?aeaeaiue,
aenia?eiaioaeueii? /anoeie c ?acoeueoaoaie ?iaioe, aiae?co ?
ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiue, aeniiae?a oa i?iiiceoe?e
ae?iaieoeoao, nieneo aeei?enoaii? e?oa?aoo?e. Oaeno aeeeaaeaiee ia 125
noi??ieao iaoeiiieno, i?noeoue 14 oaaeeoeue, 5 ?enoie?a. Nienie
e?oa?aoo?e aeeth/a? 312 aeaea?ae, o oiio /ene? 71 — ?iicaiieo aaoi??a.

Iaoa??aee ? iaoiaee aeine?aeaeaiue

?iaioa aeeiioaaeanue oi?iaeiaae 1990-1998 ??. o i?iaeaii?e
iaoeiai-aeine?aei?e aeieiai-a?ioaoiieia?/i?e eaai?aoi???
A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo ? o eaai?aoi???
nenoai aaaeaiiy oaa?eiieoeoaa a Ee?anuee?e iaeano? ?inoeoooo ?icaaaeaiiy
? aaiaoeee oaa?ei OAAI, a oaeiae o ieaicaaiae? “Oa?aceia”.

C oaie aeena?oaoe?? i?iaaaeaii iiaeaeuei? aenia?eiaioe ? o?e
iaoeiai-ainiiaea?nuee? aeine?aee ia iieiaeiyeo aaeeei? ?iaaoi? ooaeiae.

Aeey ?iiia?e?caoe?? aeei?enoiaoaaee aetheiai?eaco A20o c aeoeai?noth
1000 iae/ a, ui ae?iaey?oueny o i?iieneiaiio ianooaa? ia Oe?a?i?
Eaaeeaeeinueeei caaiaeii “Aicei”. sse iin?? aeei?enoiaoaaee oeaie?o
oiieiai iiae??aiaiiy ni?o?a A Niee?ieoeueeiai ?iaeiaeua Caea?iaonueei?
iaeano? oa aa?inee (i??iaaiiee e?aiiacai).

?iiia?e?caoe?th aetheiai?eace i?iaiaeeee iaoiaeii aaeni?aoe?? ia
oeaie?o? ? aa?inee? o aoeaoaoiiio aooa?? c ?I 5,0 oa aeenoeeueiaai?e
aiae? i?e iino?eiiio ia?ai?ooaaii? oi?iaeiaae 2 aiae. c iine?aeo/ei
a?aeieaaiiyi iaaaeni?aiaaiiai oa?iaioo oeyoii oeaio?eooaoaaiiy.

O iaoeiai-ainiiaea?nueeeo aeine?aeao a oiiaao ae?iaieoeoaa
?iiia?e?coaaee aetheiai?eaco ia oeaie?o?, noniaiciaaiiio o aiaeiiio
?ic/ei? oa?iaioo ?c ?ic?aooieo ia a?oio oaa?ei, oeyoii ia??iaee/iiai
ia?ai?ooaaiiy oi?iaeiaae 4 aiae.

O iiaeaeueieo aeine?aeao in vitro aecia/aee iioeiaeuei? ia?aiao?e
?iiia?e?caoe?? aetheiai?eace ia oeaie?o? oa aa?inee?, a oaeiae aieea
aeaiaoo?oth/eo oaeoi??a ia ?iiia?e?ciaaiee oa?iaio. Iioeiaeueia
ni?aa?aeiioaiiy oa?iaio: iin?e: ??aeeia anoaiiaethaaee aenia?eiaioaeueii
oeyoii i?aeai?o ??cieo eiioeaio?aoe?e eiiiiiaio?a, i?e yeeo caa??aaeanue
iaeaeua aeoeai?noue oa?iaioo.

Caeaaei?noue eaoae?oe/ii? aeoeaiino? aetheiai?eace a?ae ?I na?aaeiaeua
aecia/aee i?ney ?ieoaaoe?? iaaaaeee oa?iaioo oi?iaeiaae 20 oa. i?e 370 o
nieyiieeneiio ?ic/ei?, aoeaoaoiiio oa oinoaoiiio aooa?ao o ae?aiacii? ?I
1,5 — 8,0. Aaee/eio ?I aeei?enoiaoaaieo ?ic/ei?a aei??thaaee ia
iioaioe?iiao?? ?I — 340.

Eaoae?oe/io aeoeai?noue aetheiai?eace aea/aee ca ?? ai?eie?oe/iith
aeoeai?noth, yeo aecia/aee ca e?euee?noth ?icuaieaiiai e?ioiaeth ca?aeii
AINOo 20264.- 4-89.

Aeanoeaino? ?iiia?e?ciaaiiai oa?iaioo ioe?ithaaee oeyoii ii??aiyiiy
eiai aeoeaiino? c aeoeai?noth iaoeaii? aetheiai?eace.

O iaoeiai-ainiiaea?nueeeo aeine?aeao aea/aee aieea ?iiia?e?ciaaii?
aetheiai?eace ia a?io?i?/i? iieacieee oa i?iaeoeoeai?noue iieiaeiyeo
aaeeei? ?iaaoi? ooaeiae.

Aeey i?iaaaeaiiy iaoeiai-ainiiaea?nueeeo aeine?ae?a aoee i?ae?a?ai? ca
i?eioeeiii ciioaoi?/ieo aiaeia?a oaeyoa /i?ii-?yai? ii?iaee o a?oe?
2-3-o i?nyoe?a ia ii/aoie aenia?eiaioo c o?aooaaiiyi a?eo, noao?, aeeai?
iane oa aia?a?? ?inoo. Aeine?aee i?iaiaeeeenue iaoiaeii caaeainiaaieo
a?oi — aiaeia?a c aeiaea?aeaiiyi on?o iaoiaee/ieo aeiia iinoaiiaee
ciioaoi?/ieo aenia?eiaio?a (Ianyii?eia A.?., 1976) ca?aeii noai
(oaaeeoey 1).

Eiaeiiio aeine?aeo ia?aaeoaaa i?aeaioia/ee ia??iae o?eaae?noth 20-30
aei?a, i?ae /an yeiai ia?aa??yeanue iaeii??aei?noue i?ae?a?aieo oaa?ei.
O?eaae?noue iniiaiiai ia??iaeo neeaaeaea a?aeiia?aeii aeey ? aeine?aeo —
88 aei?a, ?? — 102 ? ??? — 93 aei?.

Aiae?aeth oaa?ei cae?enithaaee ca?aeii ii?i AANAI?E (1985). I?e
aaeainoaaii? ?aoe?ii?a ca ai?noii i?e?iaeaiaio?a, aeei?enoiaoaaeenue
aeai? aeanieo aeine?aeaeaiue ei?i?a ainiiaea?noaa.

Oaaeeoey 1

Noaia aeine?ae?a

Ii?yae-eiaee ? a?oieI?ecia/aiiy a?oieE?euee?noue aie?a o a?oi?Oiiae
aiae?ae? oaa?ei? aeine?ae?

??

???eiio?ieueia

aeine?aeia ?

aeine?aeia ??12

12

12Iniiaiee ?aoe?ii (I?)

I? + iaoeaia aetheiai?eaca

(5 iae/ aie/ aeiao)

I? + ?iiia?e?ciaaia aetheiai?eaca (5 iae/ aie/ aeiao)?? aeine?ae?

??eiio?ieueia

aeine?aeia12

12Iniiaiee ?aoe?ii (I?)

I? + ?iiia?e?ciaaia aetheiai?eaca (5 iae/ aie/ aeiao)??? aeine?ae?

??

???

?Veiio?ieueia

aeine?aeia ?

aeine?aeia ??

aeine?aeia ???11

11

11

11Iniiaiee ?aoe?ii (I?)

I? +?iiia?e?ciaaia aetheiai?eaca

(5 iae/ aie/ aeiao)

I? + iaoeaia aetheiai?eaca

(5 iae/ aie/ aeiao)

I? + oeaie?o (0,5 a ia 1 ea aeeai? iane)

Aeii?oee iaoeaii? oa ?iiia?e?ciaaii? aetheiai?eace, nieae
i?e?iaeaiaio?a, yeeo ia aenoa/aei aei ii?ie, iiia?aaeiuei ?ic/eiai? o
aiae?, a oeaie?o o neio/iio aeaeyae? aaiaeeee iaeii?aciai o
eiioeaio?iaai? ei?ie i?e ?o ia?ai?ooaaii? aaciina?aaeiuei ia?aae
caiaeiaoaaiiyi. Aetheiai?eaco aeiaeaaaee a aeicao, ?aeiiaiaeiaaieo
caaiaeii-ae?iaieeii ?c a?aooaaiiyi ?? oaeoe/ii? aeoeaiino?. Eaoae?oe/i?
aeoeaiino? iaoeaiiai oa ?iiia?e?ciaaiiai oa?iaioo i?e aeiaeaaaii? ?o aei
?aoe?iio aoee iaeiaeiaeie.

O iniiaiee ia??iae aeine?ae?a aecia/aee aeeiai?eo aeeai? iane oaa?ei
oeyoii ?o ?iaeea?aeoaeueiiai caaaeoaaiiy iaeei ?ac ia i?nyoeue.

C iaoith aecia/aiiy ni?yiiaaiino? iaoaaie?/ieo i?ioean?a o i?aai?ci?
oaeyo i?ae ae??th aeii?oie o e?ioe? ae?oaiai ? o?aoueiai aeine?ae?a aoei
acyoi e?ia a?ae oanoe aie?a c eiaeii? a?oie ? aecia/aii aeaye?
a?io?i?/i? iieacieee.

Ne?iaaoeo e?ia? iaea?aeoaaee oeaio?eooaoaaiiyi i?e 2000 ia/ oa., a
oe?eueio e?ia noaa?e?coaaee aaia?eiii.

O ne?iaaooe? e?ia? aecia/aee ai?no caaaeueiiai a?eea ca Lowry O.H. et
al. (1951), aeoeai?noue ai?iio?ainoa?ac ca Iano?iith O.N. (Iie?ianueeee
I.I., 1969), eoaeii? oinoaoace — iaoiaeii Bodansky A. (Iie?ianueeee
I.I., 1969), eaoaeace — iaoiaeii Aaoa ? Coaeiai? (Caa?nueeee A.?. oa
?i., 1954).

O oe?euei?e e?ia? ciaoiaeeee eiioeaio?aoe?th ioeea?iiaeo eeneio (AeIE ?
?IE) — ca Oeaiaaei ?.A. oa Ia?eiaei A.A. o iiaeeo?eaoe?? Eeeiiaa I.I.,
Ei?iieneiaa A.O. (1970).

O e?ia?, aieinyiiio iie?ea? ? ei?iao aeine?aeaeoaaee ai?no iae?i- oa
i?e?iaeaiaio?a iaoiaeii aoiiii-aaeni?aoe?eii? niaeo?ioioiiao??? ia
niaeo?ioioiiao?? N-302. C?acee iiia?aaeiuei aenoooaaee, iio?i iciethaaee
o iooaeuei?e ia/?, iinooiiai aeiaiaey/e oaiia?aoo?o aei 4500 N (Oaaacia
?., Oeaeaa Ae., 1983).

Iaea?aeaiee oeeo?iaee iaoa??ae i?aeaeaaaee a?iiao?e/i?e ia?iaoe?
iaoiaeii Iiioeaa?/thoa-A?eiaaia A.I. (1964).

?acoeueoaoe aeine?aeaeaiue

Aea/aiiy ia?aiao??a ?iiia?e?caoe?? aetheiai?eace A20o

O iiaeaeueieo aeine?aeao in vitro aecia/ai? iioeiaeuei? oiiae
?iiia?e?caoe?? aeciaaiiiai oa?iaioiiai i?aia?aoo ai?eie?oe/iiai niaeo?o
ae?? — aetheiai?eace A20o. Ia?ai? aeey oe??? iaoe iin?? oeaie?o ?
aa?inee a?aeiia?aeathoue on?i aeiiaai, ye? aenoaathoueny aei oe??? a?oie
?a/iaei, oa ui iniaeeai aaaeeeai, aaea ciaeoee canoinoaaiiy o aiae?ae?
n?euenueeiainiiaea?nueeeo oaa?ei ? aeaioiaeaii? e?ea?nueeeo cania?a.

I?e i?iaaaeaii? ?iiia?e?caoe?? aetheiai?eace ia oeaie?o? aoei
anoaiiaeaii iioeiaeueio e?euee?noue oa?iaioo, caeaoiiai aaeni?aoaaoenue
ia iiaa?oi? iin?y — 2 ia/ie ?ic/eio. I?e ciaioaii? eiioeaio?aoe??
niinoa??aaee cieaeaiiy aeoeaiino? ?iiia?e?ciaaii? aetheiai?eace;
ca?eueoaiiy e?eueeino? oa?iaioo i?ecaiaeeoue aei oiai, ui cia/ia eiai
e?euee?noue caeeoa?oueny o ?ic/ei? ? ia aeei?enoiao?oueny ca
i?ecia/aiiyi.

Iaeaeuo ?ie?noue iin?y (oeaie?oo) aoei aeinyaiooi, eiee ni?aa?aeiioaiiy
oa?iaio : iin?e (oeaie?o) : ??aeea oaca neeaaeaei a?aeiia?aeii 20 ia : 1
a : 10 ie i?e ia?ai?ooaaii? oi?iaeiaae 2 aiaeei.

Aa?aneiaieii A.A. ? A?othoeueeei A.N. (1991) aoei anoaiiaeaii, ui
iioeiaeueiei aeey i?iaaaeaiiy ?iiia?e?caoe?? aetheiai?eace A20o ia
oeaie?o? ? aoeaoaoiee aooa? c ?I 5,0. C iaoith ni?iuaiiy ? caeaoaaeaiiy
oaoiieia?? iaea?aeaiiy ?iiia?e?ciaaiiai i?aia?aoo iaie aoei i?iaaaeaii
ii??aiyeueia aea/aiiy aoaeoeaiino? i?ioeano ?iiia?e?caoe?? ia
aoeaoaoiiio aooa?? c ?I 5,0 ? aeenoeeueiaai?e aiae?.

Aeine?aeaie aeiaaaeaii caa?aaeaiiy aeniei? eaoae?oe/ii? aeoeaiino?
oa?iaioo i?e ?iiia?e?caoe?? eiai o aiae? (64%); i?e canoinoaaii?
aooa?iiai ?ic/eio aeo?ae eaoae?oe/ii? aeoeaiino? aeinyaa? 65,9%.

Iaie a iiaeaeueieo aeine?aeao oaeiae aea/aeanue iiaeeea?noue
aeei?enoaiiy aeey ?iiia?e?caoe?? aetheiai?eece aa?ineeo. ?iiia?e?caoe?th
i?iaiaeeee aaeni?aoe?eiei iaoiaeii ca noaiith, yeo aoei aeei?enoaii a
aenia?eiaioao c oeaie?oii.

Onoaiiaeaii, ui iioeiaeueiith ? eiioeaio?aoe?y oa?iaioo 1 ia / ie
?ic/eio, yea i?e ni?aa?aeiioaii? oa?iaio : iin?e : ?ic/ei a?aeiia?aeii
10 ia : 0,5 a : 10 ie caaacia/o? iaeaeuee aeo?ae oa?iaioaoeaii?
aeoeaiino? o aeenoeeueiaai?e aiae? ? aoeaoaoiiio aooa?? c ?I 5,0
a?aeiia?aeii 67,7 oa 68,2% o ii??aiyii? c aeoeai?noth iaoeaii?
aetheiai?eace. ?noioii? ??cieoe? o eaoae?oe/i?e aeoeaiino?
?iiia?e?ciaaiiai i?aia?aoo i?e cai?i? aooa?iiai ?ic/eio ia
aeenoeeueiaaio aiaeo ia aeyaeaii (68,2 i?ioe 67,7%).

*an eiioaeoo oa?iaioo c iin??i i?e ia?ai?ooaaii? noaiiaeoue 2 aiaeeie.

Aea/aiiy noaa?eueiino? ?iiia?e?ciaaii? aetheiai?eace in vitro

Aenia?eiaioaeueii i?aeoaa?aeaeaii, ui aieiaiith ia?aaaaith
?iiia?e?ciaaieo oa?iaio?a iaae iaoeaieie oi?iaie ? ?o aeniea
oaoiieia?/i?noue, yea i?iyaey?oueny a?eueo aenieith noaa?euei?noth aei
aeaiaoo?oth/eo /eiiee?a. I?e iaea?aeaii? iiaeeo?eiaaieo oa?iaio?a,
aaeaioiaaieo aei iio?aa oaa?eiieoeoaa, aaaeeeaei aeaiaoo?oth/ei oaeoi?ii
? ?I ai?noeiiai oeoieiai-eeoeiaiai o?aeoo.

O iiaeaeueieo aeine?aeao aea/aee no?ee?noue ?iiia?e?ciaaii? ? iaoeaii?
aetheiai?eace aei ae?? ?aaeoe?? na?aaeiaeua a ae?aiacii? ?I a?ae 1,5 aei
8,0.

Onoaiiaeaii, ui aetheiai?eaca, yea ?iiia?e?ciaaia ia oeaie?o? a
aoeaoaoiiio aooa?? c ?I 5,0 ? aeenoeeueiaai?e aiae?, caa??aa? naith
eaoae?oe/io aeoeai?noue i?e cia/aiiyo ?I, e?eoe/ieo aeey iaoeaii? oi?ie
— o neeueii eeneiio (?I 1,5) ? eoaeiiio (?I 8,0) na?aaeiaeuao
aeoeai?noue ciaoiaeeoueny a?aeiia?aeii ia ??ai? 45 ? 40% oa 41,1 ? 30%.
Iaoeaiee oa?iaio i?e oae?e ?aaeoe?? na?aaeiaeua iiai?noth ?iaeoeao?oueny
(?en. 1).

Aiaeia?/i? ?acoeueoaoe aoei iaea?aeaii ? i?e aei?iaoaaii? noaa?eueiino?
aetheiai?eace, ?iiia?e?ciaaii? ia aa?inee? o aooa?iiio ?ic/ei? c ?I 5,0
? aeenoeeueiaai?e aiae? (?en. 2). ?iiia?e?ciaaiee oa?iaio caa??aa?
eaoae?oe/io aeoeai?noue a?aeiia?aeii ia ??ai? 43,9 ? 27,8% oa 22,0 ?
6,7%, oiae? ye iaoeaia aetheiai?eaca o oeeo oiiaao iiai?noth ao?a/a?
naith aeoeai?noue.

Ii??aiyiiy iieaciee?a noaa?eueiino? ?iiia?e?ciaaii? aetheiai?eace
na?ae/eoue i?i oa, ui oeaie?o a yeino? iao?eoe? ia? iaaio ia?aaaao iaae
aa?ineeii ye i?e aeei?enoaii? aoeaoaoiiai aooa?o, oae ? aeenoeeueiaaii?
aiaee o neeueii eeneiio (?I 1,5 — 2,0) oa eoaeiiio (?I 8,0)
na?aaeiaeuao, oiae? ye aa?inee o ae?aiacii? ?I 3,6 — 6,0 (?en. 3, 4).

Oe? aeanoeaino? iaea?aeaieo a?ieaoae?caoi??a ia iniia? aeciaaiiiai
oa?iaioiiai i?aia?aoo aetheiai?eace iathoue cia/aiiy i?e ae??oaii?
ieoaiiy ?o iiaeaeueoiai canoinoaaiiy. Acaaae?, aeei?enoaiiy oeaie?oo o
yeino? iin?y aea? iiaeeea?noue noai?eoe a?eueo oi?aa?naeueiee i?aia?ao,
yeee caa??aa? eaoae?oe/io aeoeai?noue o oe?ieiio ae?aiacii? ?I.

Ioaea, aei aeai?o iin?y ne?ae i?aeoiaeeoe aeeoa?aioe?eiaaii c
o?aooaaiiyi oe?eueiaiai aeei?enoaiiy i?aia?aoo. C iaeyaeo ia oa, ui
iaoith iaoeo iiaeaeueoeo aeine?aeaeaiue aoei iaea?aeaiiy a?ieaoae?caoi?a
aeey eiai aeei?enoaiiy o aiae?ae? iieiaeiyeo aaeeei? ?iaaoi? ooaeiae,
aea?? coieieee ia oeaie?o?.

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01050000001402690068010c0000002403040067016a006e016b006f016a006801690005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?en. 4. Caeaaei?noue aeoeaiino?
aetheiai?eace, ?iiia?e?ciaaii? ia oeaie?o? (1) ? aa?inee? (2) o
aeenoeeueiaai?e aiae? a?ae ?I na?aaeiaeua

Noai iaoaaie?cio a i?aai?ci? oaeyo i?e canoinoaaii? ?iiia?e?ciaaii?
aetheiai?eace

Ioe?ieo ?aaeoe?? i?aai?cio ia aaaaeaiiy a ?aoe?ii aeii?oie
?iiia?e?ciaaii? aetheiai?eace oa eiiiiiaio?a, ye? aoee aeo?aeieie aeey
?? iaea?aeaiiy (iaoeaiee oa?iaio ? oeaie?o), i?iaiaeeee ia i?aai?ciiaiio
? ia oeaieiiiio ??aiyo ca iieacieeaie i?iaeoeoeaiino? oa a?io?i?/ieie
ia?aiao?aie, ye? aecia/eeenue o e?ia? oaeyo. Aeine?aeaeoaaee
?ioaineai?noue ? ni?yiiaai?noue a?ineioaoe/ieo i?ioean?a oeyoii
aecia/aiiy ie?aieo iieaciee?a a?eeiaiai iai?io oa aeoeaiino? oa?iaio?a
(aeai?i — oa ania?oaoai?iio?ainoa?ac), ai?noo ioeea?iiaeo eeneio (AeIE ?
?IE), aeoeaiino? ieneaei?aaeoeoac ? eoaeii? oinoaoace oa eiioeaio?aoe??
i?e?iaeaiaio?a o e?ia? oa aieinyiiio iie?ea?.

O aenia?eiaioao ia anoaiiaeaii aieeao aeii?oie ia ai?no caaaeueiiai
a?eea, eiioeaio?aoe?y yeiai o aeine?aeieo ? eiio?ieueieo a?oiao aoea
i?aeoe/ii iaeiaeiaith (oaae. 2).

??aaiue AeIE (oaae. 2) o e?ia? aeine?aeieo oaa?ei cia/iith i??ith
caeaaeeoue a?ae neeaaeo ?aoe?ii?a, ia oii? yeeo aeei?enoiaoaaeenue
aeii?oee. Ia ceiiaeo ?aoe?iiao (?? aeine?ae) ai?no AeIE o e?ia?
aeine?aeieo oaa?ei aoa ia ??ai? eiio?ieueieo, oiae? ye ia e?oi?o
?aoe?iiao (??? aeine?ae) niinoa??aaeinue ca?eueoaiiy eiioeaio?aoe?? AeIE
ia 13,3 — 29,5% a on?o aeine?aeieo a?oiao (??, ???, ?V), aea
a??ia?aeiei aoei i?aeaeuaiiy ai?noo AeIE o?eueee o a?oiao c aeii?oeaie
?iiia?e?ciaaii? ? iaoeaii? aetheiai?eace.

Ai?no ?IE (oaae. 2) aoa a??ia?aeii ca?eueoaiei a on?o aeine?aeieo
a?oiao o iaio aenia?eiaioao, ca aeeeth/aiiyi a?oie, oaa?eie yei?
iaea?aeoaaee oeaie?o. O oaeyo, yeei caiaeiaoaaee ?iiia?e?ciaaio
aetheiai?eaco, e?euee?noue ?IE o e?ia? ye o ae?oaiio, oae ? a o?aoueiio
aeine?aeao aoea a?aeiia?aeii ia 44,3 ? 13,4% aeua, i?ae a eiio?ie? ? ia
4,1% a?eueoa, i?ae a a?oi? c aeii?oeaie iaoeaii? aetheiai?eace.

Oaaeeoey 2

Ai?no a?eea ? ioeea?iiaeo eeneio o e?ia? oaeyo, I±m

?A?oieCaaaeueiee Ioeea?iia? eeneioe, ia % ?aeine?aeoa?eie, a %AeIE?IE

???

??6,62±0,32

6,73±0.2341,65±7,88

41,21±3,23153,14±21,10

221,00±18,42*

????

??

???

?V7,51±0,06

7,44±0,08

7,33±0,09

7,41±0,0763,45±3,91

82,17±2,60*

76,81±2,87*

71,90±2,45*143,16±4,99

162,32±4,67*

155,58±2,84*

152,39±3,78 I?ei?oea: * — ??cieoey a??ia?aeia

Ci?ie, ye? niinoa??aaeenue a eiioeaio?aoe?? ioeea?iiaeo eeneio o e?ia?,
na?ae/aoue, ui i?ae aieeaii aeciaaiii? aetheiai?eace a?aeaoaa?oueny
aeoeaaoe?y neioaco ioeea?iiaeo eeneio o i?aai?ci? oaeyo, i?e/iio
iaea?eueo ?noioia ae?y oa?aeoa?ia aeey ?iiia?e?ciaaii? ?? oi?ie.

Iaeiei ?c iaea?eueo ?ioi?iaoeaieo iieaciee?a a?eeiaiai iai?io ?
aeoeai?noue ania?oao- ? aeai?iai?iio?ainoa?ac, ye? eaoae?cothoue
ia?aianaiiy ai?iia?oi. I?ioean o?ainai?ioaaiiy a?aeaoaa?oueny ia ia?o?e
noaae?? eaoaaie?cio ai?iieeneio ? oaeaee?noue iaeiie/aiiy a?eea a
i?aai?ci? o aaaaoueio aeiaaeeao aecia/a?oueny aeoeai?noth aeaieo
oa?iaio?a. O iaoeo aeine?aeao (oaae. 3) a??ia?aeia i?aeaeuaiiy
aeoeaiino? ania?oaoai?iio?ainoa?ace ia 32,5% ? 28,6% aoei o?eueee o
e?ia? oaeyo, ye? iaea?aeoaaee aeii?oee ?iiia?e?ciaaiiai oa?iaioo ye aei
ceiiaeo, oae ? e?oi?o ?aoe?ii?a. I?e aaaaeaii? o ?aoe?iie iaoeaii?
aetheiai?eace oa oeaie?oo aeoeai?noue ania?oaoai?iio?ainoa?ace aoea
i?aeoe/ii ia ??ai? eiio?ieth. Aeoeai?noue aeai?iai?iio?ainoa?ace o
aeine?aeieo a?oiao o iaio aeine?aeao aoea ieae/a ii??aiyii c eiio?ieai
ia 8,2 — 15,8%, aea ??cieoey aeyaeeanue ia a??ia?aeiith. A?aei?iiino? a
aeoeaiino? oa?iaioo i?ae aeine?aeieie a?oiaie iacia/i? ? ??aaiue
aaniethoieo iieaciee?a i?aeoe/ii iaeiaeiaee.

Oaeee noai aeoeaiino? oa?iaio?a o?ainai?ioaaiiy, ia iaoo aeoieo, ?
aeieacii aeoeaaoe?? a?ineioaoe/ieo i?ioean?a o i?aai?ci? oaeyo i?ae
aieeaii ?iiia?e?ciaaii? aetheiai?eace.

Aei aiaeia?/iiai aeniiaeo ca iieacieeaie aeoeaiino? ai?iio?ainoa?ac
ae?eoee I?ici?a E.?., Iaoe?anueeee ?.?., Aaee/ei A.A., E?aaoe?a ?.?.
(1984) i?e caaaa/aii? ?aoe?ii?a ae/e?a i?e?iaeaiaioaie ? a?oai?iaie.

Onoaiiaeaii cieaeaiiy ia ??cio aaee/eio aeoeaiino? eoaeii? oinoaoace o
oaeyo i?aeoe/ii on?o aeine?aeieo a?oi ye a ae?oaiio, oae ? o?aoueiio
aeine?aeao, ca aeiyoeii oaa?ei, ye? iaea?aeoaaee oeaie?o (?V a?.). O ieo
iieacieee aeoeaiino? oa?iaioo aoee ia ??ai? eiio?ieth (oaae. 3). Oea ?
na?ae/aiiyi ii?iaeueiiai i?io?eaiiy o iieiaeiyeo aaeeei? ?iaaoi? ooaeiae
i?ioean?a i?ia?ae?caoe?? e?noeiai? oeaieie i?e caiaeiaoaaii?
?iiia?e?ciaaii? aetheiai?eace.

Aaaaea?oueny, ui ai?no eoaeii? oinoaoace ia? ae?aaiinoe/ia cia/aiiy ?
i?aeaeuaiiy ?? aeoeaiino? o e?ia? niinoa??aa?oueny i?e e?noeiaeo
caoai?thaaiiyo oa iai?oaeaiiio noai? oinoi?ii-eaeueoe??aiai iai?io
(Oa?aeiai Ae.E., 1956; Aaneeueaaa A.A.., 1966).

A?aeiii, ui iaeiei ?c iniiaieo iieaciee?a ??aiy
ieenethaaeueii-a?aeiiaieo ?aaeoe?e a i?aai?ci? ? aeoeai?noue eaoaeace.
A??ia?aeia ca?eueoaiiy aeoeaiino? eaoaeace niinoa??aaee o e?ia? oaeyo
on?o aeine?aeieo a?oi, i?e/iio ??aaiue eaoae?oe/ii? aeoeaiino? oa?iaioo
cia/iith i??ith caeaaeeoue ye a?ae aeiaaaee, ui aeei?enoiao?oueny, oae ?
a?ae neeaaeo ?aoe?ii?a (oaae. 3). Aeii?oee ?iiia?e?ciaaii? aetheiai?eace
aei ceiiaeo ?aoe?ii?a ni?eythoue i?aeaeuaiith aeoeaiino? eaoaeace ia
21,2%, a aei e?oi?o — ia 57% (iaeneiaeueiee ??aaiue).

O a?oiao oaa?ei, yeei caiaeiaoaaee aeii?oee iaoeaii? aetheiai?eace (???
a?.) ? oeaie?oo (?V a?.), ca?eueoaiiy aeoeaiino? noaiiaeei 47,1 ? 53,8%
a?aeiia?aeii. Oea na?ae/eoue i?i aeoeaaoe?th ieenethaaeueieo i?ioean?a o
i?aai?ci? iieiaeiyeo aaeeei? ?iaaoi? ooaeiae i?e aaaaeaii? aei ?o
?aoe?ii?a aeii?oie ?iiia?e?ciaaii? ? iaoeaii? aetheiai?eace oa oeaie?oo.

Oaaeeoey 3

Aeoeai?noue oa?iaio?a o e?ia? oaeyo, I±m

? aeine?-A?o-ieAi?iio?ainoa?ace,

ie eao./eEoaeia oinoaoaca, iae.Eaoaeaca, oiiai. iae.aeoAn AoAe Ao

???

??0,631±0,076

0,836±0,041*0,207±0,048

0,190±0,0361,931 ± 0,243

1,805 ± 0,1404,05 ± 0,28

4,91 ± 0,15*

????

??

???

?V0,592±0,045

0,765±0,052*

0,624±0,070

0,603±0,0570,171±0,021

0,152±0,020

0,144±0,011

0,145±0,0071,599 ± 0,125

1,521 ± 0,117

1,600 ± 0,143

1,507 ± 0,2483,40 ± 0,42

5,34 ± 0,19*

5,00 ± 0,40*

5,23 ± 0,09* I?ei?oea: * — ??cieoey a??ia?aeia

O aeine?aeao aecia/aany aieea aeii?oie iiaeeo?eiaaiiai oa?iaioiiai
i?aia?aoo ? eiai aeo?aeieo eiiiiiaio?a ia iaoaaie?ci i?ia?aeueieo
?a/iaei o i?aai?ci? oaa?ei. Ia anoaiiaeaii ?noioiiai aieeao ia
eiioeaio?aoe?th iaai?th, cae?ca, oeeieo ? i?ae? aeii?oie ??cieo oi?i
aetheiai?eace ? oeaie?oo ye ia oii? ceiiaeo, oae ? e?oi?o ?aoe?ii?a, ca
aeiyoeii a??ia?aeieo cieaeaiiy ai?noo oeeieo ia 11% ? i?aeaeuaiiy
e?eueeino? i?ae? ia 23% o e?ia? oaeyo, ye? iaea?aeoaaee oeaie?o.

I?i oa, ui oeaie?o cieaeo? canai?iiy o i?aai?ci? iaaoeue oeeieo,
aeaco?oueny o ?iaioao Iaea?a ?.A. ? ?i. (1985). Aea a?aenooi?noue
a??ia?aeiiai cieaeaiiy oeeieo o e?ia? oaeyo, yeei caiaeiaoaaee
?iiia?e?ciaaio aetheiai?eaco, ? na?ae/aiiyi oiai, ui aeei?enoaiiy
oeaie?oo ye iin?y aeey ?iiia?e?caoe?? ia ii?ooo? aaeain oeueiai
aeaiaioo.

I?aeoaa?aeaeaiiyi ei?aeoiino? aeniiaeo ? aeine?aeaeaiiy aieinyiiai
iie?eao oaeyo (oaae. 4). Ai?no oeeieo o iueiio aoa i?aeoe/ii iaeiaeiaei
o eiio?ieueieo oaa?ei ? oaeyo, yeei aaiaeeee iiaeeo?eiaaiee oa?iaio aei
ceiiaeo ?aoe?ii?a, oiae? ye ia oii? e?oi?o ?aoe?ii?a niinoa??aa?oueny
a??ia?aeia ca?eueoaiiy oeeieo ia 32%. Aiaeia?/ia caeiiii??i?noue
a?aei?/a?oueny ? uiaei ai?noo i?ae? o aieinyiiio iie?ea?. Oe? aeai? ?
na?ae/aiiyi oiai, ui aeei?enoaiiy noaa?e?ciaaii? oi?ie aetheiai?eace o
neeaae? e?oi?o ?aoe?ii?a iiceoeaii aieeaa? ia caaacia/ai?noue i?aai?cio
oaeyo i?aeaeth ? oeeieii.

Oaaeeoey 4

Ai?no i?e?iaeaiaio?a o aieinyiiio iie?ea? oaeyo,

ia/ea nooi? ?a/iaeie, I±m

? aeine?aeoA?oieOeeieI?aeue

??I

II96,12±3,45

100,04±7,612,40±0,24

3,02±0,59

???I

II

III

IV94,23±9,62

124,35±6,61*

125,77±16,44

116,70±3,182,40±0,12

3,37±0,25*

3,17±0,45

3,20±0,14* I?ei?oea: * ??cieoey a??ia?aeia

Aieea ?iiia?e?ciaaii? aetheiai?eace ia i?iaeoeoeai?noue oaeyo

?ioaa?aeueiei oanoiaei ia?aiao?ii aieeao ??cieo oaeoi??a ia i?aai?ci
oaa?ei ? iieacieee i?iaeoeoeaiino?. O o?ueio iaoeiai-ainiiaea?nueeeo
aeine?aeao, ye? aoee i?iaaaeai? a?aeiia?aeii o e?oiuei-in?ii?e, ceiiaee
? e?oi?e ia??iaee, aea/aee aoaeoeai?noue iaea?aeaiiai a?ioaoiieia?/iei
oeyoii iiaeeo?eiaaiiai oa?iaioo aetheiai?eace, a oaeiae eiiiiiaio?a, ye?
aoee aeo?aeieie i?e eiino?othaaii? oeueiai a?ieaoae?caoi?a (iaoeaii?
aetheiai?eace ? oeaie?oo) o aiae?ae? iieiaeiyeo aaeeei? ?iaaoi? ooaeiae.

Aiae?c iaea?aeaieo ?acoeueoao?a na?ae/eoue i?i iiceoeaiee aieea
aeii?oie ia i?iaeoeoeai?noue oaeyo (oaae. 5). Iaea?eueo aenie?
na?aaeiueiaeiaia? i?e?inoe aeeai? iane aoei iaea?aeaii a on?o o?ueio
aeine?aeao o oaeyo, yeei caiaeiaoaaee ?iiia?e?ciaaiee oa?iaio. I?e/iio,
iaea?eueo aoaeoeaiith aoea aeii?oea o neeaae? e?oi?o ?aoe?ii?a, yea
ni?eyea a??ia?aeiiio i?aeaeuaiith i?e?ino?a aeeai? iane ia 22,1%; o
e?oiuei-in?ii?e ia??iae i?iaeoeoeai?noue ca?eueoeeanue ia 12,8%, a ia
ceiiaeo ?aoe?iiao — ia 10%. I?e aaaaeaii? o ?aoe?iie iaoeaii?
aetheiai?eace i?aeaeuaiiy i?e?ino?a aoei cia/ii iaioei ? neeaaeaei
a?aeiia?aeii 5,4 ? 8,9%. Iaeiaio aoaeoeaieie aeyaeeenue aeii?oee
oeaie?oo, aeeth/aiiy yeiai aei e?oi?o ?aoe?ii?a ni?eyei i?aeaeuaiith
i?iaeoeoeaiino? oaeyo ia 5,8%, ui aeyaeeinue iaa??ia?aeiei.

Iaea?aeai? ?acoeueoaoe uiaei aeoeaiino? ai?iio?ainoa?ac, eiioeaio?aoe??
?IE o e?ia? oa i?iaeoeoeaiino? na?ae/aoue, ui a i?aai?ci? oaeyo i?ae
aieeaii iaea?aeaiiai iaie iiaeeo?eiaaiiai ai?eie?oe/iiai oa?iaioiiai
i?aia?aoo niia?eueiththoueny i?ioeane aetheiiaiaaiaco oa aeoeaothoueny
a?ineioac ?eaiioeea?iiaeo eeneio ? a?eea, aiane?aeie /iai
i?iaeoeoeai?noue oaa?ei ca?eueoo?oueny.

Oaaeeoey 5

Iieacieee i?iaeoeoeaiino? oaeyo, I±m

?A?oieI?e??no aeeai? ianeaeine?aeocaaaeueiee, eana?aaeiueiaeiaiaee, a%
aei eiio?ieth

??

??

???72,90±1,86

76,80±1,81

82,20±4,18828±24,79

873±22,46

934±27,56*100

105,4

112,8

???

??65,16±1,38

71,66±1,60*638±14,0

702±15,51*100

110,0

????

??

???

?V62,36±1,39

76,18±2,11*

68,00±2,02*

66,00±3,10670±15,74

818±24,00*

730±22,47*

709±24,00100

122,1

108,9

105,8 I?ei?oea: * ??cieoey a??ia?aeia

Aeiiii?/ia ioe?iea aoaeoeaiino? aeei?enoaiiy ?iiia?e?ciaaii?
aetheiai?eace

Aeiiii?/io aoaeoeai?noue aecia/aee ca aa?o?noth aeiaeaoeiai?
i?iaeoeoe?? oa ca aeo?aoaie ia i?eaeaaiiy oa?iaioo. ?acoeueoaoe aiae?co
na?ae/aoue, ui ca ia??iae i?iaaaeaiiy ?, ?? oa ??? aeine?ae?a aoei
iaea?aeaii aeiaeaoeiai? i?iaeoeoe?? o ?ic?aooieo ia iaeio aieiao
a?aeiia?aeii ia noio 8,4; 5,8 oa 12,4 a?i. i?e aeo?aoao oa?iaioo ia 1
eii.

Aeiaeaoeiaee i?eaooie ca ??e ia 100 oiiaieo aie?a neeaaeaoeia o
caeaaeiino? a?ae ?aoe?iio aiae?ae? 2070 — 4870 a?i.

AENIIAEE

1. ?ic?iaeaii niin?a iaea?aeaiiy noaa?e?ciaaii? oi?ie oa?iaioiiai
i?aia?aoo ai?eie?oe/iiai niaeo?o ae?? oeyoii aaeni?aoe?eii?
?iiia?e?caoe?? aeciaaiiiai oa?iaioo aetheiai?eace A20o ia aa?inee?, yeee
caaacia/ea aeo?ae eaoae?oe/ii? aeoeaiino? ia ??ai? 67,7 — 68,2%.

2. Iiaeeo?eiaaii niin?a ?iiia?e?caoe?? aetheiai?eace A20o ia oeaie?o?
oeyoii cai?ie o ??aee?e oac? aoeaoaoiiai aooa?iiai ?ic/eio c ?I 5,0 ia
aeenoeeueiaaio aiaeo, ui iie?auo? oaoiieia?/i?noue ? caeaoaaeth? i?ioean
iaea?aeaiiy i?aia?aoo.

3. Aecia/ai? iioeiaeuei? ia?aiao?e i?ioeano ?iiia?e?caoe??
aetheiai?eace: eiioeaio?aoe?y oa?iaioo — 2 ia/ ie; ni?aa?aeiioaiiy
oa?iaio : iin?e : ??aeea oaca noaiiaeoue a?aeiia?aeii 20 ia : 1
a : 10 ie ( iin?e — oeaie?o ) oa –

10 ia : 0,5 a : 10 ie (iin?e — aa?inee); neeaae ??aeei? oace —
aoeaoaoiee aooa? aai aeenoeeueiaaia aiaea.

4. ?iiia?e?ciaaia ia ??cieo iin?yo aetheiai?eaca A20o no?eea o oe?ieiio
ae?aiacii? ?I na?aaeiaeua ? caa??aa? naith eaoae?oe/io aeoeai?noue ye o
eeneiio (?I 1,5), oae ? eoaeiiio (?I 8,0) na?aaeiaeuao, oiae? ye
iaoeaiee oa?iaio o oeeo oiiaao iiai?noth ?iaeoeao?oueny, ui na?ae/eoue
i?i aenieo noaa?euei?noue iaea?aeaieo i?aia?ao?a.

5. Aeiaaaeaii, ui iaea?aeaia ia oeaie?o? iiaeeo?eiaaia aetheiai?eaca
caa??aa? a?eueo aenieo ii??aiyii c iaoeaiei oa?iaioii eaoae?oe/io
aeoeai?noue i?e cia/aiiyo ?I na?aaeiaeua 2,0 oa 6,5 — 7,5, oiae? ye i?e
canoinoaaii? aa?ineeo — o ae?aiacii? ?I a?ae 3,6 aei 6,0.

6. Aeei?enoaiiy oeaie?oo ye iin?y aea? ciiao noai?eoe a?eueo
oi?aa?naeueiee a?ieaoae?caoi?, i?eaeaoiee aeey canoinoaaiiy o ?aoe?iiao
??cieo aeae?a n?euenueeiainiiaea?nueeeo oaa?ei.

7. Caaaa/aiiy ?aoe?ii?a iieiaeiyeo aaeeei? ?iaaoi? ooaeiae
?iiia?e?ciaaiith ia oeaie?o? aetheiai?eacith aeoeao? ieenethaaeuei?
a?ineioaoe/i? i?ioeane a i?aai?ci? oaeyo, i?i ui na?ae/aoue ca?eueoaiiy
o e?ia? eiioeaio?aoe?? ?IE ia 13,4 ? 44,3%, i?aeaeuaiiy eaoae?oe/ii?
aeoeaiino? ania?oaoai?iio?ainoa?ace ia 32,5 ? 29,9% oa eaoaeace — ia
21,2 ? 57%.

8. Aeei?enoaiiy noaa?e?ciaaii? aetheiai?eace o neeaae? e?oi?o ?aoe?ii?a
iiceoeaii aieeaa? ia iaoaaie?ci ? aeaiiioaaiiy i?ae? ? oeeieo, ui
i?iyaey?oueny a??ia?aeiei ca?eueoaiiyi ?o e?eueeino? o aieinyiiio
iie?ea? oaeyo a?aeiia?aeii ia 40,4 ? 32%; ia iii?/aii ?noioiiai aieeao
ia eiioeaio?aoe?th o e?ia? iaai?th, cae?ca, i?ae? ? oeeieo, a
a?aenooi?noue ci?i o aeoeaiino? eoaeii? oinoaoace ? na?ae/aiiyi
ii?iaeueiiai i?io?eaiiy o iieiaeiyeo aaeeei? ?iaaoi? ooaeiae i?ioean?a
i?ia?ae?caoe?? e?noeiai? oeaieie.

9. Caiaeiaoaaiiy aeii?oee iiaeeo?eiaaiiai i?aia?aoo ai?eie?oe/ii? ae??
iieiaeiyeo aaeeei? ?iaaoi? ooaeiae ni?ey? i?aeaeuaiith
na?aaeiueiaeiaiaeo i?e?ino?a aeeai? iane ia 10,0 — 22,1%.

I?IIICEOe?? AE?IAIEOeOAO

Aeey i?aeaeuaiiy aoaeoeaiino? aeei?enoaiiy aeciaaiii? aetheiai?eace
A20o a?o/eciyiiai ae?iaieoeoaa oa ca?eueoaiiy i?iaeoeoeaiino? iieiaeiyeo
aaeeei? ?iaaoi? ooaeiae i?e ae?iuoaaii? ?aeiiaiaeo?oueny aeiaeaaaoe aei
?aoe?ii?a cacia/aiee ?iiia?e?ciaaiee oa?iaioiee i?aia?ao o aeic?:
oaeyoai aeeaith ianith aei 150 ea – 5 iae/aie/aeiao, a a?ae 150 ea ?
aeua – 9 iae/aie/aeiao, ui aoaea noaiiaeoe a?aeiia?aeii 398 oa 717 ia
i?aia?aoo ia 1 aie/aeiao.

?ic?iaeaio oaoiieia?th ?iiia?e?caoe?? aeciaaiii? aetheiai?eace
aeeth/eoe aei ?icae?eo “?iaeaia?ia aiceiieia?y” ?iai/i? i?ia?aie
i?iaaaeaiiy eaai?aoi?ii-i?aeoe/ieo caiyoue c a?ioaoiieia?? ia
cii?iaeaia?iiio oaeoeueoao? oa oaeoeueoao? aaoa?eia?ii? iaaeeoeeie
caeeaae?a ina?oe Oe?a?ie ??? — ?V ??ai?a ae?aaeeoaoe??.

NIENIE IIOAE?EIAAIEO I?AOeUe II OAI? AeENA?OAOe??

1. Cei/aanueeee I.A. Ia?aiao?e iaoaaie?cio o oaeyo i?e caiaeiaoaaii?
?iiia?e?ciaaii? aetheiai?eace // A?niee A?eioea?e?anueeiai aea?aeaaiiai
aa?a?iiai oi?aa?neoaoo. — A?ea Oea?eaa, 1996. — aei. 1. — N. 57 — 59.

2. Cei/aanueeee I.A. Canoinoaaiiy a?ioaoiieia?/ii? aetheiai?eace aeey
i?aeaeuaiiy i?iaeoeoeaiino? oaeyo // A?niee A?eioea?e?anueeiai
aea?aeaaiiai aa?a?iiai oi?aa?neoaoo. — A?ea Oea?eaa, 1997. — aei. 3, /.
1. — N. 249 — 251.

3. Coaaoeue I.A., Aa?aneiaiei A.A., Aa?aneiaiei I.I., Cei/aanueeee I.A.
A?ioaoiieia?/i? aniaeoe i?aeaeuaiiy aoaeoeaiino? aeei?enoaiiy aeciaaiieo
oa?iaio?a o oaa?eiieoeoa? // A?niee aa?a?ii? iaoee. — Ee?a, 1998. — ? 1.
— N. 33 — 36.

4. Aa?aneiaiei A.A., Aa?aneiaiei I.I., Cei/aanueeee I.A. A?ioaoiieia?/i?
i?eeiie ?iiia?e?caoe?? aeciaaiii? aetheiai?eace ia aa?inee? // A?niee
A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo. — A?ea Oea?eaa,
1998. — aei. 4, /. 1. — N. 194 — 199.

5. Aa?aneiaiei A.A., Aa?aneiaiei I.I., Cei/aanueeee I.A. Iiaeeo?eaoe?y
niiniao ?iiia?e?caoe?? aeciaaiii? aetheiai?eace ia oeaie?o? // A?niee
A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo. — A?ea Oea?eaa,
1998. — aei. 4, /. 1. — N. 199 — 200.

6. ?aeiiaiaeaoe?? uiaei iaea?aeaiiy oa aeei?enoaiiy aeciaaiii?
aetheiai?eace o aiae?ae? iieiaeiyeo aaeeei? ?iaaoi? ooaeiae /I.A.
Coaaoeue, A.A. Aa?aneiaiei, I.I. Aa?aneiaiei, I.A. Cei/aanueeee. – A?ea
Oea?eaa, 1999. – n.

Cei/aanueeee I.A. A?ioaoiieia?y iaea?aeaiiy ? canoinoaaiiy aeciaaiii?
?iiia?e?ciaaii? aetheiai?eace o aiae?ae? iieiaeiyeo aaeeei? ?iaaoi?
ooaeiae. — ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa n?euenueeiainiiaea?nueeeo iaoe ca niaoe?aeuei?noth 03.00.20.
— a?ioaoiieia?y. Aea?aeaaiee aa?a?iee oi?aa?neoao, A?ea Oea?eaa, 1999.

?ic?iaeaii niin?a iaea?aeaiiy noaa?e?ciaaii? oi?ie oa?iaioiiai
i?aia?aoo ai?eie?oe/iiai niaeo?o ae?? aetheiai?eace A20o oeyoii
?iiia?e?caoe?? ia iin?? aa?inee?, a oaeiae iiaeeo?eiaaii iaoiae
?iiia?e?caoe?? oeueiai oa?iaioo ia oeaie?o? oeyoii cai?ie o ??aee?e oac?
aoeaoaoiiai aooa?o c ?I 5,0 ia aeenoeeueiaaio aiaeo, ui iie?auo?
oaoiieia?/i?noue ? caeaoaaeth? i?ioean iaea?aeaiiy i?aia?aoo.

?iiia?e?ciaaia aetheiai?eaca no?eea o ae?aiacii? ?I 1,5 — 8,0 ?
caa??aa? eaoae?oe/io aeoeai?noue ye o neeueii eeneiio (?I 1,5), oae ?
eoaeiiio (?I 8,0) na?aaeiaeuao; a oeeo oiiaao iaoeaiee oa?iaio iiai?noth
?iaeoeao?oueny.

Caaaa/aiiy ?aoe?ii?a iieiaeiyeo aaeeei? ?iaaoi? ooaeiae
?iiia?e?ciaaiith ia oeaie?o? aetheiai?eacith aeoeao? a?ineioaoe/i?
i?ioeane o i?aai?ci? oaeyo (ca?eueoo?oueny eiioeaio?aoe?y ?IE,
i?aeaeuo?oueny aeoeai?noue An Ao oa eaoaeace), ui ni?ey? i?aeaeuaiith
i?iaeoeoeaiino? oaa?ei ia 10,0 — 22,1%.

Eeth/ia? neiaa: oa?iaioe, iin??, ?iiia?e?caoe?y, iiaeaeuei? aeine?aee,
aaeeea ?iaaoa ooaeiaa, i?iaeoeoeai?noue, iaoeiai-ainiiaea?nuee?
aeine?aee, a?io?i?/i? iieacieee, i?e?iaeaiaioe, aoaeoeai?noue.

Cei/aaneee I.A. Aeioaoiieiaey iieo/aiey e eniieueciaaiey yeciaaiiie
eiiiaeeeciaaiiie aetheiaieeacu a ei?ieaiee iieiaeiyea e?oiiiai ?iaaoiai
neioa. — ?oeiienue. Aeenna?oaoeey ia nieneaiea o/?iie noaiaie
eaiaeeaeaoa naeueneioicyenoaaiiuo iaoe ii niaoeeaeueiinoe 03.00.20. —
aeioaoiieiaey. Ainoaea?noaaiiue aa?a?iue oieaa?neoao, Aaeay Oea?eiaue,
1999.

?ac?aaioaii niinia iieo/aiey noaaeeece?iaaiiie oi?iu oa?iaioiiai
i?aia?aoa aieeieeoe/aneiai niaeo?a aeaenoaey aetheiaieeacu A20o ioo?i
eiiiaeeecaoeee ia iineoaea ay?ineea, a oaeaea iiaeeoeoee?iaaii iaoiae
eiiiaeeecaoeee yoiai oa?iaioa ia oeaieeoa ioo?i caiaiu a aeeaeeie oaca
aoeaoaoiiai aooa?a n ?I 5,0 ia aeenoeeee?iaaiioth aiaeo, /oi oeo/oaao
oaoiieiae/iinoue e oaeaoaaeyao i?ioeann iieo/aiey i?aia?aoa.

Eiiiaeeeciaaiiay aetheiaieeaca onoie/eaa a aeeaiaciia ?I 1,5 — 8,0 e
nio?aiyao eaoaeeoe/aneoth aeoeaiinoue eae a neeueii eeneie (?I 1,5), oae
e uaei/iie (?I 8,0) n?aaea; iaoeaiue oa?iaio a yoeo oneiaeyo iieiinoueth
eiaeoeae?oaony.

Iaiaauaiea ?aoeeiiia iieiaeiyea e?oiiiai ?iaaoiai neioa
eiiiaeeeciaaiiie ia oeaieeoa aetheiaieeacie aeoeaece?oao
aeineioaoe/aneea i?ioeannu a i?aaiecia oaeyo (oaaee/eaaaony
eiioeaio?aoeey ?IE, aeoeaiinoue An Ao e eaoaeacu), /oi niinianoaoao
oaaee/aieth i?iaeoeoeaiinoe aeeaioiuo ia 10,0 — 22,1%.

Eeth/aaua neiaa: oa?iaiou, iineoaee, eiiiaeeecaoeey, iiaeaeueiua iiuou,
e?oiiue ?iaaoue neio, i?iaeoeoeaiinoue, iao/ii-oicyenoaaiiua iiuou,
aeioeie/aneea iieacaoaee, iee?iyeaiaiou, yooaeoeaiinoue.

Zlochevski M.V. Biotechnology of obtaining and use of exogene
immobilized glucoamylase for feeding young cattle. Handwriting.
Dissertation in seek for a scientific degree of candidate of agrarian
sciences on the specialty 03.00.20. — biotechnology. The state agrarian
university Bila Tserkva, 1999.

For the first time there was elaborated a method of obtaining
stabilized form of enzyme preparation of amylolithic spectrum of action
of glucoamylase G20x by immobilization on the airpower bearer, and the
method of immobilization of this enzyme on zeolite was modified by
substitution of acetate buffer in liquid phase with pH 5,0 for a
distilled water, and optimal absorption conditions were defined for
enzyme on matrix.

The selected for this aim bearers: zeolite and airpower meet all the
requirements, which are passed for this group of substances. They are
used in feeding farm animals and for preparation medical chemicals.

Optimal parameters of the glucoamylase immobilization process, which
were defined in the model experiments in vitro, are — the enzyme
concentration 2 mg/ml (bearer – zeolite) and 1mg/ml (bearer- airpower);
correlation: enzyme-bearer-liquid phase constitutes accordingly
20mg:1g:10ml (bearer – zeolite) and 10mg:0,5g:10mg (bearer – airpower);
liquid phase content – acetate buffer or distilled water.

It is established that glucoamylase immobilization on such bearers as
zeolite and airpower ensures exit of enzyme catalytic activity at the
level of 64-65,9 and 67,7-68,2% accordingly.

Maximal output of enzyme activity was reached during glucoamylaze
immobilization both on zeolite and airpower in the acetate buffer with
pH 5,0.

Substitution of acetate buffer solution by distilled water during
immobilization is not significantly decreasing the catalytic activity of
enzyme preparation, but makes it more simple and cheap.

It is known that important denaturative factor influencing albumen,
is pH of the alimentary tract content. That’s why the resistance of
immobilized and native glycoamylase against the influence of
environments ranged from 1,5 to 8,0 pH was studied in the model
experiments.

It is established that glycoamylase, immobilized on zeolite and
airpower, both: in acetate buffer with pH 5,0 and distilled water —
resistant in a wide range of pH environment and keeps its catalytic
power under the pH figures, critical for the native form – in a very
acid (pH 1,5) and alkaline (pH 8,0) environments. Native enzyme during
such environment reaction is completely inactivated. It proves high
stability of obtained bio-catalysts, which ensures their hydrolytic
ability along all alimentary tract of an animal.

Comparison of glucoamylase stability data, immobilized on zeolite and
airpower, testifies that zeolite as a matrix has advantages over the
airpower when used as acetate buffer and over distilled water under the
pH environment 2,0 and 6,5- 7,5, while airpower has advantages in the pH
range 3,6-6,0. Thus the use of zeolite as a bearer for glucoamylase
immobilization gives possibility to obtain a more universal
bio-catalyst.

Taking this in to account, the zeolite is used as bearer under the
glucoamylase immobilization for creation of modified enzyme preparation
for young cattle.

Evaluation of the obtained prolonged action bio-catalyst was done on
the organism and tissue levels on the base of animal productivity
indicators according to the state of biochemical parameters of blood,
where the level of albumen, content of nucleic acids (DNA and RNA)
aspartat activity and alanin-amino-transpherase, alkaline phosphatase
and concentration of microelements in blood and hair cover of calves.

It is established that young cattle diet enrichment with zeolite
immobilized glucoamylase, activates bio-synthetic processes in the
organism of calves, which is testified by the blood RNA concentration
increase by 13,4% and 44,3%, increase of aspartat-amino-transpherase
catalytic activity by 32,5% and 29,2% and catalase by 21,2% and 57%.

Use of stabilized glucoamylase in summer diets is positively
influencing metabolism and copperzinc deponing, which depicted by their
quantity increase in calves’ hair accordingly by 40,4 and 32%.

There was no significant influence established on concentration of
magnesium, iron, copper and zinc in blood. Absence of changes in the
activity of alkaline phosphatase is the evidence of normal run of bone
tissue mineralization processes in young cattle.

Feeding young cattle with modified enzyme preparation of amylolythic
action promotes the average day weight gain by 10-22,1% with the most
efficient preparation in-mix with summer diet.

Key words: enzymes, bearers, zeolite, airpower, immobilization, model
experiments, cattle, productivity, scientific-managerial experiments,
biochemical indicators, microelements, efficiency.

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