22

IAOe?IIAEUeIA AEAAeAI?ss IAOE OE?A?IE

?INOEOOO A?II?AAI?*II? O?I?? OA IAOOIO?I??

OAeE 678.664:577.15:616.3:615 .462

?IAEIIAA

??oa Aiaoie??aia

A?IEIA?*II AEOEAI? ?IIEAIOAOE IA INIIA? CAeAOIEO AeI

A?IAeANO?OEOe?? IIE?O?AOAI?A

02.00.10 – a?ii?aai?/ia o?i?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Ee?a — 1999

Aeena?oaoe?th ? ?oeiien

?iaioa aeeiiaia o a?aeae?e? a?inoi?nieo iie?ia??a iaaee/iiai i?ecia/aiiy
?inoeoooo o?i??

aenieiiieaeoey?ieo niieoe IAI Oe?a?ie

Iaoeiaee ea??aiee:

aeieoi? a?ieia?/ieo iaoe, i?ioani?

Ioaeaaeca Aai?a?e Ieaenaiae?iae/

Iaoeiaee eiinoeueoaio:

aeieoi? o?i?/ieo iaoe , i?ioani?

Aeoaie A?oae?e Aiae??eiae/

?inoeooo i?iaeai iaoa??aeiciaanoaa IAI Oe?a?ie

caa?aeoaa/ o?i?ei-aiae?oe/iiai a?aeae?eo

Io?oe?ei? iiiiaioe:

aeieoi? o?i?/ieo iaoe, i?ioani?

A?aeia Aiaoie?e Iao?iae/

?inoeooo o?i?? aenieiiieaeoey?ieo niieoe IAI Oe?a?ie

caa?aeoaa/ a?aeae?eo neioaco e?i?eieo iie?ia??a

aeieoi? a?ieia?/ieo iaoe, i?ioani?

?aaeaanueeee TH??e Eaii?aeiae/

?inoeooo a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie

caa?aeoaa/ a?aeae?eo no?oeoo?e oa ooieoe?? a?eea

I?ia?aeia onoaiiaa:

?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie, i. Ee?a

Caoeno a?aeaoaeaoueny «2» ea?oiy 1999 ?. i 10 00 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee

Ae 26.220.01 a ?inoeooo? a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie,
253660, Ee?a-94, aoe. Io?iainueea, 1

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? ?inoeoooo
a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie,

253660, Ee?a-94, aoe. Io?iainueea, 1

Aaoi?aoa?ao ?ic?neaiee » 1 » aa?aciy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
Ae.I. Oaaei?ye

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Iaiao?aei?noue noai?aiiy a?ieia?/ii aeoeaieo
?iieaioao?a aeey ieanoeee e?noeiai? oeaieie iaoiiaeaia cia/iei
?iciianthaeaeaiiyi aeaaaia?a-oeaii-aeeno?io?/ieo caoai?thaaiue o?aaoa oa
aaeeeeo noaeia?a, ye? iio?aaothoue o??o?a?/iiai e?eoaaiiy, a oaeiae
ca?eueoaiiyi e?eueeino? oai?eo c e?noeiaeie aeaoaeoaie i?ney o?aaie,
iooeei, e?no oa ?ioeo caoai?thaaiue iii?ii-?ooiaiai aia?aoo.

Aeei?enoaiiy eiino?oeoe?e aiaeii?ioac?a c iaoae?a, aei- oa
enaiio?ainieaioao?a, neioaoe/ieo oeaiei ye e?noeiaiai ieiiaoaaeueiiai
iaoa??aeo iaiiaeeeaa a ca’yceo c ?o a?aeiiniith a?inoi?ni?noth oa
aenieith aonoeiith.

No/ania o?i?y iie?ia??a iaaea? a?ieia?? oa iaaeeoeei? iaiaiaaeaiee
ani?oeiaio aeo?aeieo iie?ia??a, ye? iiaeooue aooe iniiaith aeey
aeaioiaeaiiy a?ieia?/ii aeoeaieo eiiiiceoe?eieo e?noeiaeo ?iieaioao?a.

Aaeueie aeooaeueii aeei?enoiaoaaoe a yeino? iin?y a?ieia?/ii aeoeaieo
?a/iaei ii?eno? iie?o?aoaie, ye? iathoue caeaoi?noue aei
a?iaeano?oeoe??, a oaeiae iie?ia?ecothoueny a aeaoaeoi?e ii?iaeiei?
i?eeiath/e ?? oi?io oa ooai?thth/e aaeaac?eiee ca’ycie ia iaae?
?iciiae?eo iie?ia? – e?noea.

Ne?ae a?aecia/eoe, ui eeoa aeaye? aeaiaioe a neeaae? iie?o?aoaiiaiai
?iieaioaoo iiaeooue neoaeeoe oeaio?aie ?aaaia?aoe?? oa iaoiiaethaaoe
iiaeaeueoa ?ioaineaia cai?uaiiy cacia/aiiai aiaeii?ioaco ?aaaia?iaaiith
e?noeith. Aei oaeeo a?ieia?/ii aeoeaieo ?a/iaei iaeaaeeoue
a?ae?ieneaiaoeo (AAI), yeee a?aeiineoueny aei eaeueoe?e-oinoaoii?
a?iea?ai?ee.

A oeueiio iai?yieo ni?eueieie coneeeyie iaaeee?a oa o?i?e?a-neioaoee?a
aeinyaioo? /eiae? oni?oe, aea caeeoa?oueny aeineoue aaaaoi iaae??oaieo
i?iaeai, o oiio /ene? ieoaiiy uiaei iiaeeeaino? noeioethaaiiy i?ioeano
?aaaia?aoe?? e?noeiai? oeaieie ca ?aooiie iaaeaiiy iie?ia?iiio
?iieaioaoo niaoeeo?/ii? a?ieia?/ii? aeoeaiino?.

Oi/a a na?oia?e i?aeoeoe? (J.J. Quist, 1995, W. Bonfield, 1998)
?ioaineaii i?iaiaeyoueny ?iaioe ii noai?aiith eiiiiceoe?eieo iie?ia?ieo
iaoa??ae?a aeey aiaeii?ioacoaaiiy, ye? i?noyoue a nai?io neeaae?
a?iea?ai?eo, aea a?ieia?/ii aeoeaieo iie?ia?ieo ?iieaioao?a ia iniia?
caeaoieo aei a?iaeano?oeoe?? iie?o?aoai?a, ye? iiaee a noeioethaaoe
i?ioean inoaineioaco c iaeii/aniei cai?uaiiyi e?noeiaei ?aaaia?aoii, ia
nueiaiaei? ua iaaeinoaoiuei.

Aea/aiiy caeiiii??iinoae i?ioean?a aca?iiae?? iie?o?aoaiiaeo
?iieaioao?a, iaiiaiaieo a?ieia?/ii aeoeaieie niieoeaie, c oeaieiiei
na?aaeiaeuai i?aai?cio ia?aaeaa/a? aeaoaeueia aea/aiiy ?o
o?ceei-o?i?/ieo aeanoeainoae in vivo oa in vitro.

Iiaeeea?noue iaaeaiiy aiaeii?ioaco e?eoaaeueieo aeanoeainoae
i?ieiiaiaaii? ae??, ni?yiiaaieo ia noeioethaaiiy ooieoe?e ee?oeiiiai
eaioethaa ?ioiii? nenoaie, ? oaeiae iaeiei c iniiaieo iai?yie?a o
i?iaeai? noai?aiiy a?ieia?/ii aeoeaieo ?iieaioao?a aeey i?oiiaae??.
Iniaeeai oea aaaeeeai i?e ieanoeoe? e?noeiaeo aeaoaeo?a, ooai?aieo
aiane?aeie iaoieia?/ieo i?ioean?a (inoaii??e?o, aanoean A?iae?, iooeeie
oa ?io?.).

Ae??oaiiy on?o oeeo ieoaiue aaaeeeaa ye a oai?aoe/iiio, oae ? a
i?aeoe/iiio aniaeoao. Oea, ianaiia?aae, oe?eani?yiiaaiee iiooe
a?ieia?/ii aeoeaieo niieoe, ye? iathoue inoaio?iiio, i?oiaaiio (H.S.
Cheunig, 1984) ae?th, oa e?ea?nueeeo ?a/iaei, ? noai?aiiy i?eioeeiiai
iiaeo ?iieaioao?a aeey aiaeii?ioacoaaiiy, caeaoieo ?ioaineaii
noeioethaaoe ?aaaia?aoe?th e?noeiai? oeaieie c iaeii/aniith
i?ieiiaiaaiith oa?iaeieia?/iith ae??th a i?noe? canoinoaaiiy.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa aeeiioaaeanue a ?aieao oaiaoe/ieo ieai?a ?OAN IAI Oe?a?ie ca?aeii
c i?ia?aiith «Noai?aiiy iie?ia?ieo caeaoieo aei a?iaeano?oeoe??
?iieaioao?a, ye? ni?eythoue i?ioeanai ?aaaia?aoe?? a i?noe?
canoinoaaiiy, oa iie?ia??a, no?eeeo a na?aaeiaeuao i?aai?cio» (1993-1997
?.?.), iiia? aea?ae?a?no?aoe?? 0198U001263.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa ?iaioe — ia iniia? i?iaaaeaieo
o?ceei-o?i?/ieo oa a?ieia?/ieo aeine?aeaeaiue aenia?eiaioaeueii
iaa?oiooaaoe iiaeeea?noue noai?aiiy iiaeo a?ieia?/ii aeoeaieo
iie?o?aoaiiaeo ?iieaioao?a aeey aiaeii?ioacoaaiiy, caeaoieo ?ioaineaii
noeioethaaoe i?ioeane e?noeiooai?aiiy caaaeyee aaaaeaiith aei ?o neeaaeo
a?ae?ieneaiaoeoo, yeee neoaeeoue iniiaith i?ioean?a inoaineioaco a
?aaaia?oth/?e oeaiei?.

Caaea/? aeine?aeaeaiiy:

1. Noai?aiiy a?ieia?/ii aeoeaieo ?iieaioao?a aeey ieanoeee e?noeiai?
oeaieie, caeaoieo ?ioaineaii noeioethaaoe i?ioean inoaineioaco.

2. Aea/aiiy aieeao iai?aai?/ii? neeaaeiai? iie?o?aoaiiaeo eiiiiceoe?e ia
?o o?ceei-o?i?/i? aeanoeaino? a oiiaao in vivo c aeei?enoaiiyi
o?ceei-o?i?/ieo oa a?ieia?/ieo iaoiae?a aiae?co.

3. Aeine?aeaeaiiy iiaeeeaino? iaaeaiiy i?ieiiaiaaii? e?eoaaeueii? ae??
iie?o?aoaiiaei eiiiiceoe?yi c a?ae?ieneaiaoeoii.

4. Aeine?aeaeaiiy no?oeoo?ii-ii?oieia?/ieo ci?i iie?o?aoaiiaeo
eiiiiceoe?e c a?ae?ieneaiaoeoii oa ?ioiiiiaeoeyoi?ii — eaaai?cieii (EAA)
i?ae aieeaii na?aaeiaeua i?aai?cio.

5. Aea/aiiy iiaeeeaino? aeoeaaoe?? inoaiaaiaco i?e canoinoaaii?
?ic?iaeaieo a?ieia?/ii aeoeaieo iie?o?aoaiiaeo eiiiiceoe?e.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. ?acoeueoaoii i?iaaaeaii?
?iaioe ? iaoeiaa iaa?oiooaaiiy aeioe?eueiino? noai?aiiy iie?o?aoaiiaeo
?iieaioao?a c a?iea?ai?eith oa aea/aiiy o?ceei-o?i?/ieo oa?aeoa?enoee
oeeo iaoa??ae?a i?e ?iieaioaoe?? a i?aai?ci.

Aaoi?ii aia?oa aeei?enoaii a?ieia?/ii aeoeaio ea?ai?eo (a?ae?ieneaiaoeo)
a neeaae? iie?o?aoaiiai? iniiae c iaoith iaaeaiiy ?e caeaoiino?
?ioaineaii noeioethaaoe i?ioean inoaooai?aiiy.

Aaoi?ii aia?oa iieacaii:

— aaaaeaiiy a?ae?ieneaiaoeoo oa eaaai?cieo a ??cieo ni?aa?aeiioaiiyo a
iie?o?aoaiiao iao?eoeth cia/ii i?aeaeuo? ?? caeaoi?noue aei aaeaac??;

— i?enooi?noue a?ae?ieneaiaoeoo a caeaoi?e aei a?iaeano?oeoe??
eiiiiceoe?? noeioeth? i?ioean iaeiie/aiiy iai?aai?/ii? neeaaeiai?
e?noeiai? oeaieie ii an?e ?? ian?;

— i?enooi?noue a?ae?ieneaiaoeoo a eiiiiceoe?? c eaaai?cieii ia ciaioo?
i?ioeaio aeoiaeo e?e?a a oiiaao in vitro ?, oaeei /eiii, ia ciaioo? eiai
oa?iaeieia?/io ae?th in vivo.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a iieyaa? a noai?aii? iiaeo
a?ieia?/ii aeoeaieo iie?ia?ieo ?iieaioao?a, caeaoieo ?ioaineaii
noeioethaaoe i?ioeane ?aaaia?aoe?? e?noeiai? oeaieie caaaeyee
i?enooiino? a eiiiiceoe?? a?iea?ai?ee (a?ae?ieneaiaoeoo), yea ? oeaio?ii
inoaineioaco.

Iiaeaeueoa ai?iaaaeaeaiiy a iaaee/io i?aeoeeo aeuacacia/aieo ?iieaioao?a
a?aee?eaa? iia? iiaeeeaino? a oaeineiiaeaii? oaoi?ee o??o?a?/iiai
ao?o/aiiy, ui ianaiia?aae i?eaaaea aei ciaioaiiy /ano iia?aoe?e oa
i?neyiia?aoe?eieo oneeaaeiaiue.

Iie?o?aoaiia? eiiiiceoe?? c a?ae?ieneaiaoeoii i?ieoee oieneeieia?/i?
aei?iaoaaiiy ? iiaeooue aooe ?aeiiaiaeiaai? aeey ee?i?/ieo aei?iaoaaiue.

Iniaenoee aianie aeena?oaioa iieyaa? a noai?aii? a?ieia?/ii aeoeaieo
iie?ia?ieo ?iieaioao?a aeey ieanoeee e?noeiai? oeaieie, a oaeiae o
aeeiiaii? eaai?aoi?ieo aeine?aeaeaiue oa aenia?eiaio?a ia oaa?eiao.
Aaoi?o iaeaaeaoue ocaaaeueiaiiy, aiae?c io?eiaieo ?acoeueoao?a oa
aenoiaiiy a?iioac, ye? iiyniththoue iaoai?cie aea/aieo i?ioean?a.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?eii? ?iaioe
aoee i?aaenoaaeai? ia VIII Oe?a?inuee?e eiioa?aioe?? c
aenieiiieaeoey?ieo niieoe (Ee?a, 1996), 8 Iaoe?iiaeuei?e oeie?-nai?ia??
c i?aeia?iaeiith o/anoth «Niaeo?ineii?y iieaeoe ? e?enoae?a» (Noie,
1997), 3rd Seminar and Meeting on Ceramics, Cells and Tissues
«Bioceramic coatings for Guided bone growth» (Italy, Faenza, 1996);
International Surgery Congress: Wounds, Burns, Dressing (Tel-Aviv,
Israel, 1998). Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ia iaoeia?e nan??
A?aeae?eaiiy o?i?? IAI Oe?a?ie, i?enay/ai?e 80-??//th IAI Oe?a?ie
(Oa?e?a, 1998). ?acoeueoaoe ?iaioe aeiiia?aeaeenue ? iaaiai?thaaeenue ia
can?aeaiiyo a/aii? ?aaee oa iaoeiaeo nai?ia?ao a ?inoeooo? o?i??
aenieiiieaeoey?ieo niieoe IAI Oe?a?ie.

Ioae?eaoe??. Iaoa??aee aeena?oaoe?eii? ?iaioe aeeeaaeai? o 10
ioae?eaoe?yo, c ieo 6 noaoae a iaoeiaeo aeo?iaeao ? a iaoa??aeao
iaoeiai? nan?? oa 4 oace eiioa?aioe?e. No?oeoo?a oa ianya ?iaioe.
Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 146 noi??ieao iaoeiiieniiai oaenoo ?
neeaaea?oueny c? anooio, 3 ?icae?e?a: iaeyaeo e?oa?aoo?e, iieno
iaoa??ae?a ? iaoiae?a, ?acoeueoao?a oa iaaiai?aiue, cae?i/aiiy,
aeniiae?a, oa nieneo aeei?enoaieo e?oa?aoo?ieo aeaea?ae, ui i?noeoue 163
iineeaiue ia ?iaioe a?o/eciyieo oa ca?oa?aeieo a/aieo. Iaoa??aee
aeena?oaoe?eii? ?iaioe ?ethno?iaai? 23 ?enoieaie oa 10 oaaeeoeyie.

Iaoiaeieia?y oa iaoiaee aeine?aeaeaiiy. Ia’?eoaie aeine?aeaeaiiy aoee
iie?o?aoaiia? eiiiiceoe?? c a?ieia?/ii aeoeaieie niieoeaie –
a?ae?ieneaiaoeoii oa eaaai?cieii. A?noioiene/i?noue ?ic?iaeaieo
eiiiiceoe?e aecia/aee iaoiaeii eoeueoo?e oeaiei (Aaeaoaiei I.A., 1979).
Ii noaiaea?oi?e iaoiaeeoe? aecia/aee i?oei?noue ia cnoa iie?ia?ieo
eiiiiceoe?e c ??ciei ai?noii a?ae?ieneaiaoeoo. Aieea a?ieia?/ii aeoeaieo
iaiiaithaa/?a ia o?ceei-o?i?/i? aeanoeaino? iie?o?aoaiiaeo eiiiiceoe?e a
oiiaao in vivo aea/aee ca aeiiiiiaith iaoiaeo ??aiiaaaeiiai iaa?yeaiiy
O. ?aia?a (Flory R., 1953), iaoiaeii aaaaoie?aoiiai ii?ooaiiiai iiaiiai
aioo??oiueiai a?aeaeaaiiy (AIIAA) niaeo?ineii??, ?aioaaii-no?oeoo?iei
aiae?cii. I?e ?iieaioaoe?? caoaa?ae?eeo eiiiiceoe?e a i?aai?ci
aenia?eiaioaeueieo oaa?ei aeoeai?noue eeneeo oa eoaeieo oinoaoac a
niieo/iioeaieiieo eainoeao aecia/aee iaoiaeii Aannay-Eio??-A?aea
(Eiia?ia O.?., 1976). Ai?no a?eea aecia/aee ca A?aaeoi?aeii (Bradford
M.M., 1976). I?iaiaeeee a?noieia?/i? aeine?aeaeaiiy niieo/iioeaieiieo
eainoe i?e noaeooaeuei?e ?iieaioaoe?? iie?o?aoaiiaeo eiiiiceoe?e c
a?ae?ieneaiaoeoii oa i?e ieanoeoe? e?noeiaeo aeaoaeo?a
aenia?eiaioaeueieo oaa?ei, caaa?aeaiiy oeaiei ii Aiii??. Aeo?ae e?e?a
(eaaai?cieo) c iie?o?aoaiiaeo eiiiiceoe?e aecia/aee ca aeiiiiiaith
aeno?aoe?eii-oioiiao?e/iiai iaoiaeo (Ei?aiiai E.I., 1977, Ia/a?aa E.TH.,
Aaeaoaiei I.A. 1989). No?oeoo?ii-ii?oieia?/i? ci?ie a ?iieaioaoao c
a?ae?ieneaiaoeoii oa eaaai?cieii aeine?aeaeoaaee ?aioaaii-no?oeoo?iei
iaoiaeii aiae?co. Iaea?aeai? aenia?eiaioaeuei? aeai? ii?aoeueiaai?
noaoenoe/ii (Iiioeaae/ooa-A??iaaia A.A., 1964; Iea?i E.A., 1960).

INIIAI? ?ACOEUeOAOE AeINE?AeAEAIIss

Ii??aiyeueia ioe?iea caeaoiino? aei aaeaac?? eiiiiceoe?eiiai iaoa??aeo
aeey ieanoeee e?noeiaeo aeaoaeo?a

C iaoith noai?aiiy eiiiiceoe?eiiai iaoa??aeo aeey ieanoeee e?noeiaeo
aeaoaeo?a aeei?enoai? aeo?aei? eiiiiiaioe :

1. Iie?ia?ia iniiaa – ie?aiao??o?aoaiae??cioe?aiao ia iniia?
iie?ienei?ii?eaiae?eieth (iie?ao?? ia?ee Eai?ie 1502) oa
oieo?eaiae??cioe?aiaoo (O65/35);

2. I?enei?thaa/ iie?ia?ecaoe?? — 2,4,6-o?en(aeeiaoeeai?iiiaoee)oaiie;

3. A?iea?ai?ea — a?ae?ieneaiaoeo;

4. E?ea?nueea ?a/iaeia – eaaai?cie.

Ia iniia? aeacaieo eiiiiiaio?a io?eiai? eiiiiceoe?? (IO-20AAI,
IO-30AAI, IO-20AAI-6EAA, IO-30AAI-6EAA), aea ai?no a?ae?ieneaiaoeoo
neeaaeaa 20 % oa 30 % aei iane iie?ia?ii? iniiae. E?euee?noue
eaaai?cieo, a?aoiaoth/e eiai oa?iaeieia?/io ae?th, neeaea 6 % aei iane
iie?o?aoaio.

Iie?ia?ia iniiaa ? noi?ooth iae?iae??cioe?aiao?a caaaeueii? oi?ioee:

OCN – R – NH – C-O — NI2 – NI — In – C – NH — R – NCO, (1)

||
||

O
CH3 O

aea R — caeeoie oieo?eaiae??cioe?aiaoo (OAe?) O 65/35; caaaeueia noia
?ciia??a 2,4-, 2,6- ia iaioa 99,6 %;

n – nooi?iue iie?ia?ecaoe?? iie?ienei?ii?eaiae?eieth (n = 15-35).

?aaeoe?y iie?i?e?aeiaiiy eiiiiceoe?? a?aeaoaa?oueny i?ae aieeaii aieiae
aeeaeo oeaiei (o aeiaaeeo oaa?ae?iiy a na?aaeiaeu? i?aai?cio) ?
i?ecaiaeeoue aei ooai?aiiy ea?aai?aeieo ca’yce?a. Caoaa?ae?eee
iie?o?aoaiiaee iin?e yaey? niaith n?o/anoee iie?ia? i?e?iii?enoi?
no?oeoo?e c aeioaiaoieie oa a?o?aoiaeie aoceaie ?icaaeoaeaiiy, eio??
a?ae?ie?cothoueny a i?ioean? a?iaeano?oeoe?? iie?o?aoaio.

Caaaeueia no?oeoo?a caoaa?ae?ei? iie?ia?ii? iniiae:

o?aoai

O O
O
(2)

|| || ||

— R- N – C – O – R1 – O – C – NH – R — NH – C – O – R1 –

|

CO- NH – R – NH – C – O – R1- O – C – NH – R – NH – C = O

|| ||
|

aeioaiao O O
N __________ R —

|

O=C

|

NH__________R-

a?o?ao

R — caeeoie oieo?eaiae??cioe?aiaoo, (OAe?) O 65/35;

R1 — caeeoie iie?ienei?ii?eaiae?eieth, II = 1500.

1. Aeioaiaoi? aocee ?icaaeoaeaiue.

-R–NCOO–R1-+ HOH -R–NHCOO–R1- + -R–NHCOOH
(3)

CONH–R –

-R–NH–COOH -R-NH2 + CO2
(4)

2. A?o?aoia? aocee ?icaaeoaeaiue.

-R–NCONH–R- + HOH -R–NHCONH–R- + -R-NHCOOH
(5)

CONH–R-

-R–NH–COOH -R–NH2 + CO2
(6)

Iaei??th c iaeaaaeeea?oeo oa?aeoa?enoee iaiiaiaieo iie?o?aoaiiaeo
eiiiiceoe?e, ye? iiaeooue aeei?enoiaoaaoenue aeey ieanoeee e?noeiai?
oeaieie, ? ?o caeaoi?noue ooai?thaaoe i?oeiee aaeaac?eiee ca’ycie ia
iiaa?oi? ?iciiae?eo aeaio na?aaeiaeu e?noea-iie?ia?ia eiiiiceoe?y.

C iaoith aeai?o iaea?eueo iioeiaeueiiai neeaaeo iie?ia?ii? eiiiiceoe?? c
a?iea?ai?eith aeey ieanoeee e?noeiai? oeaieie i?iaiaeeee ii??aiyeueia
aea/aiiy o?ceei-o?i?/ieo ia?aiao??a ?yaeo io?eiaieo eiiiiceoe?e ia
iniia? iie?o?aoaio c ??ciei ai?noii a?ae?ieneaiaoeoo.

Aeine?aeaeaiiy iie?ia?ieo eiiiiceoe?e ia i?oei?noue, yea iaoiiaeaia ?
aaeaac?eieie aeanoeainoyie, iieacaee (oaae.1), ui noi?nia aaaaeaiiy aei
neeaaeo iie?o?aoaiiaiai iin?y a?ae?ieneaiaoeoo oa eaaai?cieo cia/ii
i?aeaeuo? ?? cia/aiiy.

Oaaeeoey 1 – Aaeaac?ei? aeanoeaino? iie?ia?ieo eiiiiceoe?e, ye? i?noyoue
a nai?io neeaae? a?ae?ieneaiaoeo oa eaaai?cie

I?oei?noue ia cnoa, o 10,
IIaIOIO-20AAIIO-30AAIIO-20AAI-6EAAIO-30AAI-6EAA0,5+0,1

0,44+0,0570,38+0,1521,14+0,11,11+0,016

A iiaeaeueoiio aeine?aeaeoaaeenue eiiiiceoe?? c 20 % ai?noii
a?ae?ieneaiaoeoo (IO-20AAI, IO-20AAI-6EAA), ai iaiiaiaiiy iie?o?aoaio 30
% a?ae?ieneaiaoeoo ca?eueoo? /an i?eaiooaaiiy oa oaa?ae?iiy eiiiiceoe?e,
ui iaaaaeaii i?e ?o aeei?enoaii? ca i?ecia/aiiyi.

Aea/aiiy aieeao iai?aai?/ii? neeaaeiai? iie?o?aoaiiaeo eiiiiceoe?e ia ?o
o?ceei-o?i?/i? aeanoeaino? in vivo

I?iaeaia noai?aiiy ?iieaioao?a aeey ieanoeee e?noeiai? oeaieie ia iniia?
iie?o?aoaiiaeo iin??a, iaiiaiaieo a?iea?ai?eith, iio?aao? ?aoaeueiiai
aea/aiiy aieeao iai?aai?/ii? neeaaeiai? eiiiiceoe?e ia ?o o?ceei-o?i?/i?
aeanoeaino? a oiiaao aioo??oiueiai na?aaeiaeua i?aai?cio.

C oe??th iaoith caoaa?ae?e? iie?o?aoaiia? eiiiiceoe?? IO-20AAI,
IO-20AAI-EAA, a oaeiae eiio?ieuei? c?acee IO, IO-6EAA o aeaeyae?
ae??aiiii?enoeo aoaie aoee noaeooaeueii ?iieaioiaai? aenia?eiaioaeueiei
oaa?eiai ia ??ci? oa?i?ie.

O?ceei-o?i?/i? ci?ie o aeuacacia/aieo eiiiiceoe?yo a oiiaao in vivo
aeine?aeaeoaaee ca aeiiiiiaith iaoiae?a ??aiiaaaeiiai iaa?yeaiiy
Oei??-?aia?a, AIIAA niaeo?ineii??, ?aioaaii-no?oeoo?iei aiae?cii.

?acoeueoaoe aeine?aeaeaiiy o?ceei-o?i?/ieo aeanoeainoae (oaae.2)
iieacaee, ui aeey eiio?ieueieo c?ace?a IO, IO-6EAA aei 6 i?nyoe?a
?iieaioaoe?? ia? i?noea i?aeaeuaiiy cia/aiue ??aiiaaaeiiai nooiaith
iaa?yeaiiy oa ciaioaiiy cia/aiue aonoeie. Iaaiaee, iie?ia?i? eiiiiceoe??
c a?ae?ieneaiaoeoii (IO-20AAI, IO-20AAI-6EAA) aei 6 i?nyoe?a
?iieaioaoe?? ciaioothoue cia/aiiy ??aiiaaaeiiai nooiaith iaa?yeaiiy oa
ca?eueoothoue naith aonoeio.

Oaaeeoey 2 – Ci?ia aeeooc?eieo ia?aiao??a oa aoaeoeaii? aonoeie coeaee a
oiiaao in vivo aeey iie?o?aoaiiaeo eiiiiceoe?e, ye? i?noyoue AAI

Ia??iae, i?nyoeueNeeaae eiiiiceoe?e??aiiaaaeia

nooi?iue

iaa?yeaiiy

Ia’?iia aeiey iie?ia?o a iaa?ye-io

c?aceoAonoeia iie?ia?.

c?acea,

ea/i3Aoaeoeaia aonoeia coeaee,

iieue-1

eiio?ieueIO1,86450,34910,70440,03995
IO-6EAA1,80660,35630,79190,05323IO-20AAI5,69550,14820,84290,01030IO-20AA
I-6EAA3,73970,21150,89510,012001IO
2,17950,30280,67740,03289IO-6EAA2,08450,32420,83300,02458IO-20AAI2,38720
,29590,76600,02080IO-20AAI-6EAA1,82760,35820,65300,020423IO3,14110,24190
,68540,02550IO-6EAA2,91540,25540,79340,01072IO-20AAI2,29370,30510,79320,
02900IO-20AAI-6EAA2,55480,28500,85990,021006IO3,81100,26240,78530,01170I
O-6EAA4,29100,18900,76540,01060IO-20AAI2,85090,25970,76990,04200IO-20AAI
-6EAA2,20510,31200,85000,02600

Oaeei /eiii, aeey eiio?ieueieo c?ace?a IO oa IO-6EAA ?c ca?eueoaiiyi
/ano ?iieaioaoe?? niinoa??aa?oueny ciaioaiiy cia/aiue aoaeoeaii? aonoeie
coeaee, ui ? na?ae/aiiyi i?ioeano ?o a?iaeano?oeoe??. A oie aea /an,
aeey c?ace?a eiiiiceoe?e IO-20AAI, IO-20AAI-6EAA niinoa??aa?oueny
ca?eueoaiiy cia/aiue aoaeoeaii? aonoeie coeaee, i?e/iio, aeey
eiiiiceoe?? IO-20AAI-6EAA oe? cia/aiiy iaio?, ui iiaea aooe iiyniaii
i?enooi?noth eaaai?cieo, yeee, ye a?aeiii, iineeth? ee?oeiiee oeyo
a?iaeano?oeoe?? iie?ia?ii? iniiae c iaeii/aniei i?enei?aiiyi i?ioean?a
?aaaia?aoe??.

Io?eiai? ?acoeueoaoe iiyniththoue aeai? AIIAA niaeo?ineii?? oa
?aioaaii-no?oeoo?iiai aiae?co.

Ia niaeo?ao iie?o?aoaio i?ae aieeaii na?aaeiaeua aeeaiai i?aai?cio ia?
i?noea cieaeaiiy a?aeiinii? ?ioaineaiino? nioa iiaeeiaiiy a iaeanoyo
1720 ni-1 (Ai?aeI,N=I), 1230 ni-1 (N-I, C-N ), 1100 ni-1 (N-I, N-N).
Ciaioaiiy ?ioaineaiino? aeacaieo nioa iiaeeiaiiy c /anii ia?aaoaaiiy
c?ace?a iie?o?aoaio a oiiaao in vivo iia’ycaia c a?ae?ie?cii neeaaeiiai
oa i?inoiai ao??iiai ca’yceo iie?ia?ii? iniiae, ui ? aeieacii i?ioeano
?? a?iaeano?oeoe??.

I?e ii??aiyii? ?*-niaeo??a iie?o?aoaio, a?ae?ieneaiaoeoo oa eiiiiceoe?e
IO-20AAI, IO-20AAI-6EAA aoei anoaiiaeaii, ui i?enooi?noue AAI a iie?ia??
/?oei aeyaeeanue iayai?noth nioa iiaeeiaiiy 575, 610, 635 ni-1
a?ae?ieneaiaoeoo.

*a?ac o?e i?nyoe? ia?aaoaaiiy a i?aai?ci? ia ?*-niaeo?ao c?ace?a
eiiiiceoe?e c AAI niinoa??aathoueny ci?ie, ye? a?eueo /?oei i?iyaeai?
i?ney 6 i?nyoe?a ?iieaioaoe?? oa ae?aaeai? a cia/iiio ca?eueoaii?
?ioaineaiino? nioa iiaeeiaiiy a?ae?ieneaiaoeoo 575, 610, 635 ni-1.

?*-niaeo?e, ciyo? c iiaa?oi? oa aioo??oiuei? /anoeie aeine?aeaeoaaieo
c?ace?a, na?ae/aoue i?i c?inoaiiy a ieo e?eueeino? AAI c /anii
ia?aaoaaiiy a na?aaeiaeu? i?aai?cio, i?e/iio ia o?eueee ia iiaa?oi?, a e
ii an?e ian?.

Io?eiai? aeai? (oaae. 3) aeicaieythoue aeaoe e?euee?nio ioe?ieo
aeyaeaiiai aoaeoo ca?eueoaiiy e?eueeino? a?ae?ieneaiaoeoo a eiiiiceoe?yo
IO-20AAI, IO-20AAI-6EAA, ye? ia?aaoaaee o?eaaeee /an a i?aai?ci?
aenia?eiaioaeueieo oaa?ei.

Oaaeeoea 3 — Aeaii? AIIAA niaeo?ineii?? aeey iie?ia?ieo eiiiiceoe?e c
a?ae?ieneaiaoeoii aei oa i?ney ?iieaioaoe??

?C?acieA?aeiioaiiy iioe/ii? aonoeie nioa iiaeeiaiiy 575

830575

1230575

1380610

830610

1230610

1380ni-1

N?.1.IO-20AAI eiio?.1,320,500,561,100,420,46_2.IO-20AAI, 6 i?n. ?iie.,
aa?o. oa?4,101,101,422,90,971,00_3.IO-20AAI ,6 i?n.

?iie., aioo?. oa?2,700,960,962,220,790,79_4.IO-20AAI-6EAA

eiio?ieue1,30,50,561,10,410,46_5.IO-20AAI-6EAA

6 i?n. ?iieaioaoe??2,601,101,302,200,951,15_6.IO-20AAI

?2/?13,12,82,52,62,32,22,67.IO-20AAI

?2/?31,51,41,51,31,21,21,358.IO-20AAI-6EAA

?5/?42,02,22,32,02,32,52,2

Oae, ca 6 i?nyoe?a ?iieaioaoe?? a c?aceo IO-20AAI e?euee?noue AAI
ca?eueoeeanue a 2,6 ?ace. I?e oeueiio, a na?aaei?e /anoei? ii oiauei?
c?aceo eiai e?euee?noue ae?inea a 1,35 ?ace. A eiiiiceoe?? IO-20AAI-6EAA
e?euee?noue AAI ca?eueoeeanue a 2,2 ?ace.

Oaeei /eiii, ca?aeii c iaea?aeaieie ?acoeueoaoaie o?ceei-o?i?/ieo
aeine?aeaeaiue iie?ia?i? eiiiiceoe?? IO-20AAI, IO-20AAI-6EAA
ca?eueoothoue aonoeio coeaee o a?aeiioaii? aei eiio?ieth (IO, IO-6EAA),
a aeai? AIIAA niaeo?ineii?? aeacothoue ia cia/ia iaeiie/aiiy
iai?aai?/ii? neeaaeiai? e?noeiai? oeaieie eiiiiceoe?yie a i?aai?ci?, aei
oiai ae ia ia iiaa?oi?, a ii an?e ian?, ui iiaea a?aeaoaaoeny aiane?aeie
inaaeaeaiiy aiaoeoiai? oace c oeaieiii? ??aeeie a ?acoeueoao? i?ioeano
?ic/eio — ia?ainaaeaeaiiy a?ae?ieneaiaoeoo.

C iaoith aea/aiiy i?ioeano iaeiie/aiiy iai?aai?/ii? neeaaeiai?
e?noeiai? oeaieie iie?o?aoaiiaeie eiiiiceoe?yie IO-20AAI, IO-20AAI-6EAA
in vivo aeine?aeaeoaaee ci?ie a ?o iaaeiieaeoey?i?e oa
oaciai-e?enoae?/i?e no?oeoo?ao i?e ??cieo no?ieao ?iieaioaoe??
aenia?eiaioaeueiei oaa?eiai.

Aiae?c e?eaeo iaeieooiaiai ?icn?yiiy IO iieacaa, ui i?ae aieeaii
na?aaeiaeua aeeaiai i?aai?cio ia i?ioyc? 3-o oa 6-oe i?nyoe?a
?iieaioaoe?? ca?eueoo?oueny aeaoaeoi?noue i?inoi?iai? iae?i?ao?oee
aei?noeeo aeiiai?a iie?o?aoaiiai? iao?eoe?.

Aeey eiiiiceoe?? IO-20AAI iii?oia iine?aeiaia iaeiie/aiiy iai?aai?/ii?
neeaaeiai? e?noeiai? oeaieie c? ca?eueoaiiyi /ano ia?aaoaaiiy in vivo. A
eiio?ieueiiio c?aceo aeiiaiia no?oeoo?a aei?noeeo aeie?a iie?o?aoaiiai?
iao?eoe? neaai ae?aaeaia. Ia e?ea?e ?icn?yiiy eiiiiceoe?? IO-20AAI, yea
ciaoiaeeeanue 3 i?nyoe? a na?aaeiaeu? i?aai?cio, ?aae?co?oueny eeoa
ne?ae ?ioa?oa?aioe?eiiai iaeneioio (2 = 130′), yeee aeaiiino?o?
i?aeoe/ii iiaia ?oeioaaiiy iae?i?ao?oee aei?noeeo aeiiai?a
iie?o?aoaiiai? iao?eoe?. Oanoei?ny/ia ia?aaoaaiiy a i?aai?ci?
i?ecaiaeeoue aei iiaiiai ?? ?oeioaaiiy, ui aeeeeeaii ca?eueoaiiyi
e?eueeino? AAI a eiiiiceoe??. Na?ae/aiiyi oeueiai i?ioeano ? ca?eueoaiiy
?ioaineaiino? ?icn?yiiy iiaeeco ia?aeiiiai ?aioaai?anueeiai i?iiaith (ye
?iaeeeaoi? e?eueeino? AAI a nenoai?) a ii??aiyii? c eiio?ieueiei c?aceii
eiiiiceoe?? IO-20AAI.

Eiiiiceoe?y IO-20AAI-6EAA ia? aeaoaeoio iae?i?ao?oeo a eiio?ieueiiio
c?aceo. Ia?aaoaaiiy oe??? eiiiiceoe?? in vivo 6 i?nyoe?a i?ecaiaeeoue
aei iiaiiai ?oeioaaiiy ye iae?i?ao?oee aei?noeeo aeiiai?a, oae ? naieo
aeiiai?a, ui iaoiiaeaii, ye ? o aeiaaeeo IO-20AAI, i?ioeanii iaeiie/aiiy
AAI a eiiiiceoe?? c iaeii/aniith a?iaeano?oeoe??th iie?ia?ii? iniiae.

Aeine?aeaeaiiy oaciai-e?enoae?/ii? no?oeoo?e iie?o?aoaio oa eiiiiceoe?e
ia eiai iniia? IO-20AAI, IO-20AAI-6EAA iieacaee, ui a?ae?ieneaiaoeo ia?
e?enoae?/io oaco, yea c?inoa? c? ca?eueoaiiyi /ano ia?aaoaaiiy in vivo.
I?i oea na?ae/eoue ca?eueoaiiy ?ioaineaiino? iniiaiiai aeeo?aeoe?eiiai
iaeneioia a?ae?ieneaiaoeoo (2 = 31,5 0 ) eiiiiceoe?e IO-20AAI oa
IO-20AAI-6EAA i?e 3-o ? 6-oe i?ny/i?e ?iieaioaoe??.

I?iaaaeai? aeine?aeaeaiiy i?aeoaa?aeeee oie oaeo, ui caoaa?ae?e?
iie?ia?i? eiiiiceoe??, ye? i?noyoue a nai?io neeaae? a?ae?ieneaiaoeo oa
eaaai?cie, a oiiaao in vivo iaeiie/othoue iai?aai?/io neeaaeiao, yea
iiaea neoaeeoe iniiaith aeey i?ioean?a e?noeiooai?aiiy a ?aaaia?oth/?e
oeaiei?.

A?io?i?/ia ? a?noieia?/ia oa?aeoa?enoeee niieo/iioeaieiii? ?aaeoe?? ia
iaiiaiai? a?ae?ieneaiaoeoii a?ieia?/ii aeoeai? iie?o?aoaiia? ?iieaioaoe

I?e ?iieaioaoe?? iie?ia?ieo iaoa??ae?a c a?ieia?/ii aeoeaieie
niieoeaie, ye? aeyaeythoue aaciina?aaei?e aieea ia ee?oeie ioi/oth/eo
oeaiei, iaiao?aeia i?iaaaeaiiy eiiieaeniiai aiae?co eainoe iaaeiei
?iieaioao?a aeey ia’?eoeaii? ioe?iee ?aaeoe?? aeeeeeaii? ?iieaioaoe??th.

Iaoith aeine?aeaeaiiy aoei ii??aiyeueia aea/aiiy a?io?i?/ieo ?
a?noieia?/ieo oa?aeoa?enoee oeaiei, ye? ioi/othoue iie?o?aoaiia?
eiiiiceoe?? c a?ae?ieneaiaoeoii oa ?ioiiiiaeoeyoi?ii — eaaai?cieii i?ae
/an ?o ?iieaioaoe??.

Aoei iieacaii (oaae. 4), ui ia 14-oo aeiao ia?aaoaaiiy a na?aaeiaeu?
i?aai?cio a?aeaoaa?oueny cia/ia ca?eueoaiiy aeoeaiino? eenei? oinoaoace
(EO) o niieo/iioeaieiieo eainoeao on?o aeine?aeieo c?ace?a o ii??aiyii?
c ii?iith (i?aeoe??ia ee?oeiaeia).

Oaaeeoey 4 — Aeoeai?noue EO a ioi/oth/eo ?iieaioao niieo/iioeaieiieo
eainoeao

EO, iiieue ia-1 oa-1Iaoa??aeIa??iae ?iieaioaoe??, aeiaa143090I?aeoe??ia
ee?oeiaeia15,0 + 1,5*21,0 + 2,7*18,0 + 1,2*IO35,2 + 2,6*26,8 + 2,6*22,9
+ 6,1*IO-6EAA47,9 + 3,4*28,9 + 2,5*31,4 + 5,5*IO-20AAI59,5 + 5,9*30,1 +
3,2*31,7 + 3,0*IO-20AAI-6EAA37,1 + 1,5*24,0 + 1,1*38,1 +
4,9**A?aei?iiino? o ii??aiyii? c ii?iith aeinoia??i? (p<0,01 - 0,05) Io?eiai? aeai? ocaiaeaeothoueny c ?acoeueoaoaie ?ioeo aeine?aeiee?a, aea iienaii, ui i?e ?iieaioaoe?? iie?ia?ieo iaoa??ae?a, ye? aeano?oeoothoue, aeoeai?noue EO c?inoa? ia 14 aeiao aeine?aeaeaiue ? iiaea caeeoaoeny, a caeaaeiino? a?ae ?ioaineaiino? a?iaeano?oeoe??, aeineoue aenieith i?ioyaii o?eaaeiai /ano. Iaeaeu? cia/aiiy aeoeaiino? EO a niieo/i?e oeaiei?, yea ioi/o? iie?ia?i? eiiiiceoe?? c a?ae?ieneaiaoeoii (IO-20AAI). Ia ae?oaiio i?noe? ca aeoeai?noth EO o eainoeao ciaoiaeyoueny iie?ia?i? eiiiiceoe??, ye? i?noyoue eaaai?cie (IO-6EAA), ia o?aoueiio - IO-20AAI-6EAA. *a?ac 1 i?nyoeue a?aeaoaa?oueny cieaeaiiy aeoeaiino? EO o niieo/iioeaieiieo eainoeao on?o ?iieaioiaaieo c?ace?a caoaa?ae?eeo iie?ia?ieo eiiiiceoe?e c? caa?aaeaiiyi iaeaea o??? ae iine?aeiaiino?, ui ? ia 14 aeiao. *a?ac o?e i?nyoe? ?iieaioaoe?? aeoeai?noue EO o niieo/iioeaieiieo eainoeao c?ace?a eiiiiceoe?e IO-20AAI, IO-20AAI-6EAA, IO-6EAA c?inoa? c iaeaeuei cia/aiiyi aeey eiiiiceoe?? IO-20AAI-6EAA. Aecia/aiiy aeoeaiino? eoaeii? oinoaoace (EO) o niieo/iioeaieiieo eainoeao iie?ia?ieo eiiiiceoe?e iieacaee (oaae. 5), ui ia 14 aeiao i?ney ?iieaioaoe?? iaeaeua cia/aiiy aeoeaiino? EO o niieo/iioeaieiieo eainoeao iie?ia?ieo c?ace?a IO-20AAI, a iaeieae/a - a IO-6EAA. Aeoeai?noue EO aeey eiiiiceoe?? IO-20AAI-6EAA caeia? i?ii?aeia cia/aiiy. Oaaeeoey 5 - Aeoeai?noue EO a ioi/oth/eo ?iieaioao niieo/iioeaieiieo eainoeao EO, iiieue ia-1 oa-1Iaoa??aeIa??iae ?iieaioaoe??, aeiaa143090I?aeoe??ia ee?oeiaeia 4,7 + 0,6*5,0 + 0,7* 4,5 + 0,8*IO8,7 + 1,0**13,5 + 0,7**4,7 + 0,4**IO-6EAA6,0 + 0,8**17,2 + 0,5**3,7 + 0,3**IO-20AAI10,2 + 1,0**25,3 + 1,0**8,6 + 0,6**IO-20AAI-6EAA7,0 + 0,7**22,5 + 0,8**7,8 + 0,4*** A?aei?iiino? o ii??aiyii? c ii?iith aeinoia??i? (p < 0,01 - 0,05). ** A?aei?iiino? o ii??aiyii? c ii?iith aeinoia??i? (p < 0,001 - 0,05). *a?ac i?nyoeue i?ney ?iieaioaoe?? a?aeaoaa?oueny cia/ia ca?eueoaiiy aeoeaiino? EO o niieo/iioeaieiieo eainoeao c?ace?a IO-20AAI oa IO-20AAI-6EAA. Iaea?eueoa ?? cia-/aiiy a niieo/iioeaieiieo eainoeao c?ace?a IO-20AAI, a i?i?iaeueia - o c?aceao IO. *a?ac o?e i?nyoe? ?iieaioaoe?? cia/aiiy aeoeaiino? EO o niieo/iioeaieiieo eainoeao cia/ii cieaeo?oueny. Aea, ? ia oeueiio aoai? aeine?aeaeaiiy, cia/aiiy aeoeaiino? EO a niieo/iioeaieiieo eainoeao eiiiiceoe?e, ye? i?noyoue AAI, aeu? a?ae ?ioeo. Oaeei /eiii, caa?aaeaiiy iaeaeueo cia/aiue aeoeaiino? EO ia an?o no?ieao aeine?aeaeaiiy a niieo/iioeaieiieo eainoeao iie?ia?ii? eiiiiceoe?? IO-20AAI, a aeey eiiiiceoe?? IO-20AAI-6EAA ia 3-e i?nyoeue ?iieaioaoe??, na?ae/aoue i?i aenieo aeoeai?noue iae?ioaaaeueieo aeaiaio?a. Aeniea aeoeai?noue eoaeii? oinoaoace aeey oeeo aea eiiiiceoe?e aeaco? ia noeioeyoe?th i?ie?oa?aoe?? o?a?iaeanoe/ieo aeaiaio?a ca?eueiaieie ?iiaie Na2+ a?ae?ieneaiaoeoo, ui aeicaiey? c?iaeoe aeniiaie i?i ia?aa?a ?ioaineaieo i?ioean?a inoaooai?aiiy a ii?ao iie?ia?o. Aeine?aeaeaiiy niieo/iioeaieiieo eainoe a?noieia?/ieie oa a?noio?i?/ieie iaoiaeaie iieacaei, ui iaea?eueoa e?euee?noue iae?ioaaaeueieo aeaiaio?a c noaeaiio?eueieie a?aioeaie niinoa??aa?oueny ia 14 aeiao aeine?aeaeaiue o niieo/i?e oeaiei?, yea ioi/o? iie?ia?i? eiiiiceoe?? IO-20AAI. A?aeaoaa?oueny oaeiae ?ioaineaia a?inoaiiy a?aioeyoe?eii? oeaieie a ii?e iie?ia?ieo eiiiiceoe?e IO-20AAI-6EAA. *a?ac 1 i?nyoeue ia? i?noea ua a?eueo ?ioaineaia a?inoaiiy a?aioeyoe?eii? oeaieie a ii?e eiiiiceoe?e, ye? i?noyoue AAI. Aaeee? iae?ioaae c a?aioey?iei ai?noii eieae?coaaeeny a?oiaie a a?aioeyoe?ei?e oeaiei?, yea caiiaith? ii?e iie?ia?o, o niieo/iioeaieii?e eainoe?, a oaeiae o oeaieiao, ye? ?o ioi/othoue. *a?ac 3 i?nyoe? i?ney ?iieaioaoe?? i?e?ineii?/ii ia niinoa??aa?oueny ca?eueoaiiy e?eueeino? oa aeoeaiino? iae?ioaaaeueieo aeaiaio?a o niieo/iioeaieiieo eainoeao iie?ia?ieo c?ace?a IO-20AAI-6EAA, aea a?aeaoaa?oueny iiaeaeueoa o?aaiaioaoe?y ? a?inoaiiy a?aioeyoe?eii? oeaieie a ?o ii?e. Iaea?eueo ?ioaineaia iae?ioaaaeueia ?aaeoe?y aei i?ny/iiai no?ieo aeine?aeaeaiue a?aei?/a?oueny iaaeiei iie?ia?iiai ?iieaioaoo IO-20AAI-6EAA. Ca?eueoo?oueny oaeiae eiai cai?uaiiy niieo/iith oeaieiith. Oaeei /eiii, i?iaaaeai? a?io?i?/i? oa a?noieia?/i? aeine?aeaeaiiy oeaiei, ye? ioi/othoue ?ic?iaeai? a?ieia?/ii aeoeai? iie?o?aoaiia? ?iieaioaoe, aeicaieythoue c?iaeoe aeniiaie, ui aaaaeaiiy o neeaae iie?o?aoaiiai? iao?eoe? a?ae?ieneaiaoeoo ni?ey? i?ioeano iaeiie/aiiy iai?aai?/ii? neeaaeiai? e?noeiai? oeaieie a ii?ao ?iieaioaoo. Aaaaeaiiyi eaaai?cieo o eiiiiceoe??, ye? i?noyoue a?ae?ieneaiaoeo, iiaeia i?enei?eoe i?ioean a?iaeano?oeoe?? iie?ia?ii? iniiae oa ?aaaia?aoe?th ioi/oth/eo ?iieaioao oeaiei. I?ieiiaiaaia ae?y in vitro iie?o?aoaiiai? eiiiiceoe?? c a?iea?ai?eith oa eaaai?cieii Noai?aiiy ?iieaioao?a c e?eoaaeueieie aeanoeainoyie, ye? aieeaathoue ia ooieoe?? ee?oeiiiai eaioethaa ?ioiii? nenoaie i?aai?cio, ? aaaeeeaith ? aeooaeueiith caaea/ath. Aeeiai?eo aeoiaeo oa?iaeieia?/iiai i?aia?aoo – eaaai?cieo c iaea?aeaii? eiiiiceoe?? IO-20AAI-6EAA in vitro aea/aee ii ooai?aiith caaa?aeaieo i?iaeoeo?a aca?iiae?? aeine?aeaeoaaii? niieoee c i?aai?/iei aa?aieeii (?iiieo anioe?ao?a) aeno?aoe?eii-oioiiao?e/iei iaoiaeii. Iaea?aeai? ?acoeueoaoe iieacaee, ui ca 70 ae?a ?c c?ace?a iie?o?aoaiiaeo eiiii-ceoe?e IO-6EAA aeoiaeeoue a?ey 29,8 % aaaaeaii? e?eueeino? eaaai?cieo, a ?c c?ace?a, ye? i?noyoue a nai?io neeaae? a?ae?ieneaiaoeo (IO-20AAI-6EAA) – 33,6 % (oaae. 6). I?e iiaeaeueoiio aeo?eioaaii? c?ace?a ?iieaioao?a o iiaeo ii?oe?yo o?c?ieia?/iiai ?ic/eio aeo?ae e?e?a ia niinoa??aaany. Oaaeeoey 6 - Aeeiai?ea aeoiaeo eaaai?cieo c iie?o?aoaiiaeo eiiiiceoe?e IO- 6EAA oa IO-6EAA-20AAI in vitro *an aeieaaiiy E?euee?noue eaaai?cieo, yeee aeeoia c i?aia?aoo IO-6EAA a ?ic/eiE?euee?noue eaaai?cieo, yeee aeeoia c i?aia?aoo IO-20AAI-6EAA a ?ic/ei aeiaaao102% caaaeueii? e?eueeino?ao102% caaaeueii? e?eueeino?10,156+0,0052,60,148+0,0032,4620,146+0,0012,430,152+0,0032,533 0,166+0,02,760,182+0,0033,034-60,194+0,03,230,328+0,005,4670,141+0,0022, 350,206+0,003,4380,097+0,0021,610,134+0,002,2390,056+0,00,930,108+0,001, 80100,044+0,00,730,69+0,0021,1511-130,052+0,00,860,072+0,0041,2014-150,0 43+0,0030,720,060+0,001,0016-170,030+0,000,500,046+0,0040,7618-210,033+0 ,0040,550,038+0,0040,6322-280,140+0,0232,330,113+0,0041,8829-350,116+0,0 01,930,132+0,0032,2036-430,078+0,0021,300,048+0,000,8044-550,160+0,0032, 660,107+0,0041,7856-700,140+0,002,330,078+0,0051,30Caaaeueia e?euee?noue1,79+0,00329,82,02+0,00233,6 No?oeoo?ii-ii?oieia?/i? ci?ie a ?iieaioaoao c a?iea?ai?eith, ye? iathoue i?ieiiaiaaio e?eoaaeueio ae?th Io?eiai? e?ea? oe?ieieooiaiai ?icn?thaaiiy (OE?) aeo?aeieo eiiiiiaio?a iieacaee, ui i?io?eue ?icn?thaaiiy aeo?aeiiai iie?o?aoaio a aeine?aeaeoaaiiio eooiaiio ?ioa?aae? oa?aeoa?eco?oueny iayai?noth oe?ieiai aeeoociiai iaeneioio c aa?oeiith 19 0 oa c? neaai ae?aaeaiei iea/ai a iaeano? 12-140, ui na?ae/eoue i?i aii?oiee oa?aeoa? aeeaeiueiai ii?yaeeoaaiiy aeaiiai iie?o?aoaio oa iayaiino? i?e?iiaeanoae, ui neeaaeathoueny eeoa c iie?ao??iiai eiiiiiaioo. E?ea? ?icn?thaaiiy eaaai?cieo oa a?ae?ieneaiaoeoo oa?aeoa?ecothoueny iayai?noth /?oeeo ?aoeaen?a, ui oa?aeoa?ii aeey iecueeiiieaeoey?ieo niieoe. Oa?aeoa?i? iciaee e?eaeo OE? ?iaeea?aeoaeueiiai iie?o?aoaio oa a?ae?ieneaiaoeoo /?oei i?iyaeythoueny ia aeeo?aeoia?ai? a?ia?ii? eiiiiceoe??. Aenia?eiaioaeueia e?eaa iiai?noth a?aeoai?th? aaeeoeaio, oiaoi, eiiiiceoe?y IO-20AAI yaey? niaith iaoai?/io noi?o aeo?aeieo eiiiiiaio?a, no?oeoo?a ? o?i?/iee noai yeeo ia cacia? ci?i. Ia a?aei?io a?ae oeueiai, ia aeeo?aeoia?ai? nenoaie IO-6EAA niinoa??aa?oueny /anoeiaa cieeiaiiy aeo?aeii? e?enoae?/ii? oi?ie eaaai?cieo (cieeathoue ?ioaineai? ?aoeaene i?e 240, 26,40, caeeoathoueny ?aoeaene 7,50 oa 160) i?e oi?ioaaii? noi?o? oeueiai iaoa??aeo c iie?o?aoaiii. Ia e?ea?e OE? nenoaie IO-20AAI-6EAA iiai?noth a?aenooi? ?aoeaene eaaai?cieo i?e 7,50 oa 160, ye? iathoue i?noea ia aeeo?aeoia?ai? a?ia?ii? eiiiiceoe?? IO-6EAA, oa aeoaea iacia/ii i?iyaey?oueny ?aoeaen eaaai?cieo i?e 240. Ni?anoaaeaiiy a?aeiia?aeieo aeeo?aeoia?ai aeicaiey? noaa?aeaeoaaoe, ui i?enooi?noue AAI a oiiaao oi?ioaaiiy iio??eii? nenoaie ni?ey? oei ia?aoai?aiiyi eaaai?cieo, ui oa?aeoa?i? aeey a?aeiia?aeii? a?ia?ii? nenoaie. I?ney ia?aaoaaiiy eiiiiceoe?? IO-6EAA a i?aai?ci? oaa?ei niinoa??aathoueny nooo?a? ci?ie aeeo?aeoia?ai. Ii ia?oa, i?ney ia?aaoaaiiy eiiiiceoe?? i?ioyaii 3 i?nyoe?a in vivo e?enoae?/i? ?aoeaene, iaoiiaeai? iayai?noth eaaai?cieo 7,50 oa 160 , cieeathoue ? aeieea? aii?oia iea/a ?icn?yiiy a ?ioa?aae? eoo?a 13-170. Inoaii?e aoaeo i?ney iiaeaeueoiai ia?aaoaaiiy a na?aaeiaeu? i?aai?cio cia/ii ciaioo?oueny. Ii ae?oaa, aeo?eioaaiiy a i?aai?ci? (6 i?nyoe?a ?iieaioaoe??) i?eaiaeeoue aei cia/iiai i?aeaeuaiiy ?ioaineaiino? ?icn?yiiy ia i?i?iaeueieo eooao. Ia e?eaeo OE? eiiiiceoe?? IO-20AAI-6EAA i?ioyaii 3 ? 6 i?ny/iiai ia?aaoaaiiy a na?aaeiaeu? i?aai?cio aenia?eiaioaeueieo oaa?ei ?aoeaene aeo?aeiiai eaaai?cieo iiai?noth cieeathoue. A oie aea /an, i?io?eue aii?oiiai aaei i?ney iacia/iiai cieaeaiiy ?ioaineaiino? oa i?aeaeuaiiy ?ioaineaiino? ?icn?yiiy ia i?i?iaeueieo eooao a ?acoeueoao? 3-o i?ny/ii? ?iieaioaoe?? i?aeoe/ii ia aeaiiino?o? aeiaeaoeiaeo ci?i i?e 6 i?nyoe?a ?iieaioaoe??. Oaeei /eiii, io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui aaea ia aoai? io?eiaiiy aeo?aeieo eiiiiceoe?e, ui i?noyoue eeoa eaaai?cie, a?aeaoaa?oueny /anoeiaa ?oeioaaiiy eiai e?enoae?/ii? no?oeoo?e oa ia?ao?ae a aii?oiee noai. I?enooi?noue a?ae?ieneaiaoeoo a eiiiiceoe?? ni?ey? oeueiio i?ioeano. I?ney 6-oe i?nyoe?a ia?aaoaaiiy eiiiiceoe?? IO-6EAA a oiiaao in vivo niinoa??aa?oueny iiaiee ia?ao?ae eaaai?cieo a aii?oiee noai oa eiai aeieaaiiy c iie?o?aoaiiai? iao?eoe?, yea noi?iaiaeaeo?oueny a?eueo ?ioaineaiith ?? aeano?oeoe??th oa aaoa?iaai?caoe??th. I?enooi?noue a eiiiiceoe?? IO-20AAI-6EAA a?ae?ieneaiaoeoo ?noioii ni?ey? aeoiaeo eaaai?cieo c eiiiiceoe?? a oiiaao in vivo. Aeoeaaoe?y inoaiaaiaco i?e ieanoeoe? e?noeiaeo aeaoaeo?a o aenia?eiaioaeueieo oaa?ei iie?ia?ieie eiiiiceoe?yie c a?ae?ieneaiaoeoii oa eaaai?cieii C iaoith aea/aiiy i?ioeano aeoeaaoe?? inoaiaaiaco i?e ieanoeoe? e?noeiaeo aeaoaeo?a iie?ia?ieie eiiiiceoe?yie c a?ae?ieneaiaoeoii oa eaaai?cieii (IO-20AAI-6EAA) aoee ?ic?iaeai? iiaeae? iia?aoe?e ii ieanoeoe? ooo/ii io?eiaieo e?noeiaeo aeaoaeo?a o aenia?eiaioaeueieo oaa?ei (a?e? uo?e). Aoee aei?iaoaai? 3 iiaeae? iia?aoe?e: - a ia?oiio aeiaaeeo ci?iaee iiaa?oith na?aaeiuei? o?aoeie e?noee oa aeine?aeaeoaaiee iaoa??ae iaeeaaeaee ia aieo e?noeo; - a ae?oaiio aeiaaeeo e?noeo ia?an?eaee a iaeano? i?ae aa?oiueith oa na?aaeiueith /anoeiith ? iaoa??ae ?iieaiooaaee a i?noea ia?aeiio; - a o?aoueiio aeiaaeeo a?ae iaeiiai c ia?aeii?a a i?noe? ia?an?/aiiy a?aeeaioaaee ua oiaoi/ie e?noee ? ?ic?iaeaiith eiiiiceoe??th i?eeeathaaee eiai aei ooeiaeaeaiiy. *a?ac 14 ae?a o an?o o?ueio aeiaaeeao iaaeiei iie?ia?iiai ?iieaioaoo i?e i?e?ineii?/iiio aeine?aeaeaii? iaea i?noea e?oaeiee?oeiia ?aaeoe?y a?eueo ae?aaeaia c aieo i'yeeo oeaiei a?ey ?iieaioaoo. Ooo aea aeyaey?oueny niieo/iioeaieiia eainoea, aiaeia?/ia o?e, ui e i?e i?aeoe??i?e ?iieaioaoe?? caoaa?ae?eeo c?ace?a oe??? ae eiiiiceoe?? c oei aea no?ieii aeine?aeaeaiiy. A ae?eyieao i?ae iie?ia?iith eiiiiceoe??th oa e?noeith niinoa??aa?oueny a?inoaiiy iacaio?iaeueieo aeaiaio?a oa e?iaiiinieo noaeei, eio?? ?ici?uothoueny a i?eeaaeeo ii?ao iie?ia?o. A ia?oiio aeiaaeeo iaaee?nieoey iaiiaca? a?ae e?ath aeaoaeoo ia iie?ia?. I?e o?aai? e?noee (ae?oaee aeiaaeie) i?ioean iaaaaeo? ia?aeiia c?iuoaaiiy e?noee, aea niieo/iioeaieiiee iicieue ia? o?aaiaioe iie?ia?o, eio?? ? ea?eanii aeey eiai ?inoo. O o?aoueiio aeiaaeeo i?ioean eaea oeyoii aoi?eiiiai e?noeiaiai c?iuoaaiiy /a?ac aeayea ci?uaiiy e?noeiaeo oeaie?a. *a?ac 6 i?nyoe?a, o ia?oiio aeiaaeeo, c’yaey?oueny ii?iaeueia e?noea c ino??aoeyie iie?ia?iiai ?iieaioaoo, i?noeyie aiayiiai a iaaee?nieoeth, a i?noeyie eaaea/iai a i'yeeo oeaieiao a?ey e?noee. O ae?oaiio aeiaaeeo, ia io?eiai?e o?aai? ciaeaeaia ii?iaeueia e?noea, ui aeeth/a? o?aaiaioe iie?ia?o, iiaeeco yeeo ? aeae?eueea inoaiaeano?a oa inoaieeano?a, ui na?ae/eoue i?i cai?uaiiy ?iieaioaoo ?aaaia?iaaiith e?noeith. A o?aoueiio aeiaaeeo, a?noieia?/ia ea?oeia aiaeia?/ia ae?oaiio aeiaaeeo, iaeiae a?aeaoaa?oueny aeayea ci?uaiiy e?noeiaeo oeaie?a, ui iiaeiii aoei a aeeeeeaoe ?ic?inoaiiy o?yuiai? oeaieie oa ?? ?aaaia?aoe?th ii ae?oaiio oeio c?iuaiiy. Iaeiae a?aenooi?noue o?yuiaeo ee?oei a cii? o?aaie na?ae/eoue i?i oa, ui iie?ia?iee ?iieaioao aai i?enei?ea aeinoeaaiiy o?yuiaiai iicieth a e?noeiao oeaieio, aai ni?yioaaa ?? ?aaaia?aoe?th oeyoii ia?aeiiiai c?iuoaaiiy. Oaeei /eiii, caaea/o ii iiaeaethaaiith iia?aoeaiiai ao?o/aiiy ii ieanoeoe? e?noeiai? oeaieie iiaeia aaaaeaoe oni?oii caaa?oaiith. Iie?ia?i? eiiiiceoe??, ye? i?noyoue a?ae?ieneaiaoeo, noeioeththoue i?ioean e?noeiooai?aiiy ? iiaeooue aooe ?aeiiaiaeiaai? aeey ee?i?/ieo aei?iaoaaiue. AENIIAEE 1. Io?eiai? iia? a?ieia?/ii aeoeai? aiaeii?ioace oei/aniai? ae?? aeey ieanoeee aeaoaeo?a e?noeiai? oeaieie, ye? ooai?ththoueny a ?acoeueoao? ??cieo iaoieia?/ieo i?ioean?a. 2. Aia?oa aeei?enoaii a?ae?ieneaiaoeo a neeaae? iie?o?aoaia, ui a?iaeano?oeoo?, c iaoith iaaeaiiy ?iieaioaoo caeaoiino? ?ioaineaii noeioethaaoe i?ioean e?noeiooai?aiiy. 3. Anoaiiaeaii, ui aaaaeaiiy a?ae?ieneaiaoeoo oa eaaai?cieo a iie?o?aoaiiao iniiao cia/ii i?aeaeuo? ?? caeaoi?noue aei aaeaac??. 4. Iieacaii, ui i?enooi?noue a?ae?ieneaiaoeoo a iie?o?aoaiia?e eiiiiceoe?? noeioeth? i?ioean iaeiie/aiiy c oeaieiii? ??aeeie in vivo iai?aai?/ii? neeaaeiai?, yea neoaeeoue iniiaith aeey i?ioean?a e?noeiooai?aiiy a ?aaaia?oth/?e oeaiei?. 5. Aeieacaii, ui iaeiie/aiiy iai?aai?/ii? neeaaeiai? e?noeiai? oeaieie a?aeaoaa?oueny ia ia iiaa?oi?, a ii an?e ian? iie?o?aoaiiaeo eiiiiceoe?e c a?ae?ieneaiaoeoii. 6. Anoaiiaeaii, ui i?enooi?noue a?ae?ieneaiaoeoo a iie?ia?i?e eiiiiceoe?? c e?ea?nueeith ?a/iaeiith - eaaai?cieii ia ciaioo? i?ioeaioo aeoiaeo e?e?a a oiiaao in vitro ? ia cieaeo? eiai oa?iaeieia?/ii? ae?? a oiiaao in vivo. 7. Iieacaii, ui ?ic?iaeai? iie?ia?i? eiiiiceoe?? c a?ae?ieneaiaoeoii iaoiene/i?, noeioeththoue i?ioean e?noeiooai?aiiy oa iiaeooue aooe ?aeiiaiaeiaai? aeey ee?i?/ieo aei?iaoaaiue. NIENIE IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. ?iaeiiaa ?.A., Aaeaoaiei I.A., O?aiianueeee I.A., A?eoeaiei A.I., Eaaaae?a ?.A. Iie?ia?ia eiiiiceoe?y c a?iea?ai?eith aeey ieiiaoaaiiy e?noeiaeo aeaoaeo?a // Aeii. IAI Oe?a?ie.- 1997.- ? 12.- N.146-149. 2. Oaea?a I.A., Eoaianeay A.A., Eaaaaeaa A.A., ?iaeiiaa ?.A., Ioaeaaeca A.A. Enneaaeiaaiea aeeyiey -iaeo/aiey ia naienoaa iieeo?aoaiia iaaeeoeeineiai iacia/aiey // Aeii. IAI Oe?a?ie. - 1996.- ? 1.- N. 99-101. 3. ?iaeiiaa ?.A., Aaeaoaiei I.A., Caeaooi O.A., Iiuoaiei O.E., Eaaaaeaa A.A. Aeioeie/aneay oa?aeoa?enoeea niaaeeieoaeueiioeaiiie ?aaeoeee ia aeieiae/anee aeoeaiua iieeo?aoaiiaua eiieaioaou n aeae?ieneaiaoeoii // Aeii. IAI Oe?a?ie. - 1998. - ? 5.- N. 158-161. 4. Noai?aiiy a?ieia?/ii-aeoeaieo iie?ia?ieo iaoa??ae?a. Aaeaoaiei I.A., Ii/eiie I.A., ?iaeiiaa ?.A., Eaaaae?a ?.A. // Iaoeia? iniiae ?ic?iaee e?ea?nueeeo i?aia?ao?a. – O.: Iniiaa, 1998, N. 296-301. 5. Iie?o?aoaiiaa eiiiiceoe?y c a?iea?ai?eith aeey ieanoeee e?noeiaeo aeaoaeo?a, ui aeyaey? i?ieiiaiaaio e?ea?nueeo ae?th. ?iaeiiaa ?.A., Aaeaoaiei I.A., Eaaaae?a ?.A. // Iaoeia? iniiae ?ic?iaee e?ea?nueeeo i?aia?ao?a. - O.: Iniiaa, 1998, N. 192-196. 6. A?io?i?/ia ? a?noieia?/ia oa?aeoa?enoeee niieo/iioeaieiii? ?aaeoe?? ia a?ieia?/ii aeoeai? iie?o?aoaiia? ?iieaioaoe iaiiaiai? a?ae?ieneaiaoeoii. ?iaeiiaa ?.A, Aaeaoaiei I.A., Eaaaae?a ?.A. // Iaoeia? iniiae ?ic?iaee e?ea?nueeeo i?aia?ao?a. - O.: Iniiaa, 1998, N. 457-463. 7. Iie?ia?ia eiiiiceoe?y c a?iea?ai?eith ia iniia? iie?o?aoaio aeey ieanoeee e?noeiai? oeaieie. ?iaeiiaa ?.A., A?eoeaiei A.I., Naaeoeueea I.N., Aaeaoaiei I.A. // Oac. aeii. ia VIII Oe?a?inuee?e eiioa?aioe?? c aenieiiieaeoey?ieo niieoe. - Ee?a: ?OAN IAI Oe?a?ie. - 1996. - N. 76. 8. Aeine?aeaeaiiy iaoiaeii AIIAA niaeo?ineii?? iie?ia?ii? eiiiiceoe?? c a?iea?ai?eith in vivo. ?iaeiiaa ?.A., Aaeaoaiei I.A., O?aiianueeee A.I. // Oace aeiiia?aeae ia 8 Iaoe?iiaeuei?e oeie?-nai?ia?? c i?aeia?iaeiith o/anoth. Niaeo?ineii?y iieaeoe ? e?enoae?a. - Noie: NAeO.- 1997.- N. 188. 9. The stimulation of proliferation of bone tissue. Galatenko N.A., Rozhnova R.A., Dubok V.A., Kebuladze I.V., Jhon-Karlos Spallone. // 3rd Seminar and Meeting on Ceramics, Cells and Tissues; Bioceramic coatings for Guided bone growth. - Italy, Faenza.- 1996 - ?. 132. 10. A new dressing material. N. Galatenko, R. Rozhnova // International Surgery Congress: Wounds, Burns, Dressing. - Tel-Aviv: International Wound Association - 1998.- P. 77. AIIIOAOeEss ?iaeiiaa ?.A. Aeieiae/anee aeoeaiua eiieaioaou ia iniiaa aeiaeano?oeoe?oaiuo iieeo?aoaiia. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe: 02.00.10 – aeii?aaie/aneay oeiey. - Einoeooo aeii?aaie/aneie oeiee e iaooaoeiee IAI Oe?aeiu, Eeaa, 1999 a. Aeenna?oaoeey iinayuaia nicaeaieth iiauo iieeo?aoaiiauo eiieaioaoia n aeiea?aieeie aeey ieanoeee einoiie oeaie. Eco/aii aeeyiea aeieiae/anee aeoeaiuo iaiieieoaeae a ninoaaa iieeo?aoaiiauo eiiiiceoeee ia eo oeceei-oeie/aneea oa?aeoa?enoeee a oneiaeyo in vivo e in vitro. N?aaieoaeueiia eco/aiea i?i/iinoiuo oa?aeoa?enoee ?ac?aaioaiiuo iieeia?iuo eiiiiceoeee iieacaei, /oi niaianoiia aaaaeaiea a iieeo?aoaiiaoth iniiao aeae?ieneaiaoeoa e eaaaieciea a ?acee/iuo niioiioaieyo cia/eoaeueii iiauoaao aa niiniaiinoue e aaeaacee. Oeceei-oeie/aneea eciaiaiey, i?ienoiaeyuea a eiiiiceoeeyo IO-20AAI e IO-20AAI-6EAA iiae aicaeaenoaeai n?aaeu aeeaiai i?aaiecia, enneaaeiaaee n iiiiuueth iaoiaea ?aaiiaaniiai iaaooaiey Oei?e-?aiia?a, Iaoiaeii IIIAI niaeo?ineiiee, ?aioaaii-no?oeoo?iui aiaeecii. Iieo/aiiua ?acoeueoaou oeceei-oeie/aneeo enneaaeiaaiee naeaeaoaeuenoaotho i oii, /oi iieeia?iua eiiiiceoeee IO-20AAI-6EAA e IO-20AAI iinea 6-oe ianyoeaa eiieaioaoeee oaaee/eaatho ieioiinoue noeaee ioiineoaeueii eiio?iey (IO, IO-6EAA), a aeaiiua IIIAI niaeo?ineiiee oeacuaatho ia cia/eoaeueiia iaeiieaiea iai?aaie/aneie ninoaaeythuae einoiie oeaie eiiiiceoeeyie a i?aaiecia, i?e/ai ia ia iiaa?oiinoe, a ii anae ianna. Enneaaeiaaiey iaaeiieaeoey?iie e oaciai-e?enoaeee/aneie no?oeoo? iieeo?aoaiiauo eiieaioaoia IO-20AAI e IO-20AAI-6EAA iiaeoaa?aeeee oio oaeo, /oi aaaaeaiea a ninoaa aeiaeano?oeoe?oaiiai iieeia?iiai iineoaey aeae?ieneaiaoeoa niinianoaoao iaeiieaieth iai?aaie/aneie ninoaaeythuae einoiie oeaie in vivo, eioi?ay yaeyaony iniiaie einoaia?aciaaiey a ?aaaia?e?othuae oeaie. Aeioeie/aneei iaoiaeii enneaaeiaaiey auee iieo/aiu cia/aiey aeoeaiinoae eeneie e uaei/iie oinoaoac a niaaeeieoaeueiioeaiiuo eainoeao, ie?oaeathueo iieeia?iua eiieaioaou IO-20AAI, IO-20AAI-6EAA. Aunieea cia/aiey eeneie oinoaoacu aeey iieeia?iie eiiiiceoeee IO-20AAI ia ana n?iee i?aauaaiey a i?aaiecia, a aeey eiiiiceoeee IO-20AAI-6EAA e 3-i ianyoeai eiieaioaoeee, naeaeaoaeuenoaotho i aunieie aeoeaiinoe iae?ioaaaeueiuo yeaiaioia. Aunieay aeoeaiinoue uaei/iie oinoaoacu aeey yoeo aea eiiiiceoeee aiai?eo a iieueco noeioeyoeee i?ieeoa?aoeee oea?iaeanoe/aneeo yeaiaioia inaiaiaeaeaiiuie eiiaie Na2+ aeae?ieneaiaoeoa, /oi iicaieyao noaeeoue i i?ioeannao inoaia?aciaaiey a ii?ao oeacaiiuo iieeia?iuo ia?acoeia. N eniieueciaaieai yeno?aoeeiiii-oioiiao?e/aneie iaoiaeeee eco/aia aeeiaieea auoiaea eaea?noaaiiiai aauanoaa ec eiiiiceoeee IO-20AAI-6EAA e IO-6EAA (eiio?ieue) a oneiaeyo, eieoe?othueo aioo?aiithth n?aaeo aeeaiai i?aaiecia. Iieo/aiiua ?acoeueoaou iieacaee, /oi i?enoonoaea aeae?ieneaiaoeoa a iieeo?aoaiiaie eiiiiceoeee IO-20AAI-6EAA ia oiaiueoaao i?ioeaio auoiaea eaea?noaa a oneiaeyo in vitro e, neaaeiaaoaeueii, ia nieaeaao aai oa?iaeieiae/aneee yooaeo. I?iaaaeaiiua enneaaeiaaiey no?oeoo?ii-ii?oieiae/aneeo eciaiaiee a eiieaioaoao, niaea?aeaueo aeae?ieneaiaoeo e eaaaiecie, aei e iinea i?aauaaiey a i?aaiecia iieiinoueth iiaeoaa?aeaeatho iieo/aiiua ?acoeueoaou. Iieacaii, /oi oaea ia yoaia iieo/aiey enoiaeiuo eiiiiceoeee IO-20AAI-6EAA, IO-6EAA (eiio?ieue) i?ienoiaeeo ?ac?ooaiea e?enoaeee/aneie no?oeoo?u eaaaieciea e ia?aoiae aai a aii?oiia ninoiyiea. Iinea 6 ianyoeaa eiieaioaoeee a eiiiiceoeee IO-6EAA iaaethaeaaony auiuaaiea eaaaieciea ec iieeo?aoaiiaie iao?eoeu n oneeaieai i?ioeannia aa aeano?oeoeee e aaoa?iaaiecaoeee. I?enoonoaea a eiiiiceoeee IO-20AAI-6EAA aeae?ieneaiaoeoa niinianoaoao auoiaeo eaea?noaa a oneiaeyo in vivo. N oeaeueth eco/aiey i?ioeanna aeoeaaoeee inoaiaaiaca i?e ieanoeea einoiuo aeaoaeoia iieeo?aoaiiauie eiiiiceoeeyie n aeae?ieneaiaoeoii e eaaaiecieii auee ?ac?aaioaiu iiaeaee iia?aoeee ia yenia?eiaioaeueiuo aeeaioiuo. Aenoieiae/aneea enneaaeiaaiey iieacaee, /oi ai anao neo/ayo eiieaioaoeee eiiiiceoeee i?ienoiaeeo aieaa eioaineaiay ?aaeoeey ni noi?iiu niaaeeieoaeueiie oeaie e oi?ie?iaaiey einoiuo no?oeoo?. Ia ?aiieo n?ieao eiieaioaoeee i?ienoiaeeo oi?ie?iaaiea iaaeeinoieoeu iaaeaeo eiieaioaoii e einoueth, a oaeaea ?aaaia?aoeey e?ay einoe. *a?ac iieaiaea i?ienoiaeeo oi?ie?iaaiea einoiie oeaie aie?oa iieeia?iiai eiieaioaoa. Oaeei ia?acii, ?ac?aaioaiiua iiaeaeueiua iia?aoeee i?ioee oniaoii. Iieeia?iua eiiiiceoeee, niaea?aeauea AAI, noeioee?otho i?ioeann einoaia?aciaaiey e iiaoo auoue ?aeiiaiaeiaaiu aeey i?ioiaeaeaiey eeeie/aneeo eniuoaiee. Eeth/aaua neiaa: aeiaeano?oeoeey, aeae?ieneaiaoeo, eaaaiecie, iieeo?aoaiiaay eiiiiceoeey, aeieiae/aneay aeoeaiinoue, ?aaaia?aoeey. AIIOAOe?ss ?iaeiiaa ?.A. A?ieia?/ii aeoeai? ?iieaioaoe ia iniia? caeaoieo aei a?iaeano?oeoe?? iie?o?aoai?a. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 02.00.10 – a?ii?aai?/ia o?i?y. - ?inoeooo a?ii?aai?/ii? o?i?? oa iaooio?i?? IAI Oe?a?ie, Ee?a, 1999 ?. Aeena?oaoe?y i?enay/aia noai?aiith iiaeo iie?o?aoaiiaeo ?iieaioao?a aeey ieanoeee e?noeiai? oeaieie. Aea/aii aieea a?ieia?/ii aeoeaieo iaiiaithaa/?a ia o?ceei-o?i?/i? aeanoeaino? iie?o?aoaiiaeo eiiiiceoe?e a oiiaao in vivo oa in vitro. Anoaiiaeaii, ui aaaaeaiiy a?ae?ieneaiaoeoo a neeaae iie?ia?iiai iin?y noeioeth? iaeiie/aiiy iai?aai?/ii? neeaaeiai? e?noeiai? oeaieie a oiiaao in vivo, yea ? iniiaith e?noeiooai?aiiy a ?aaaia?oth/?e oeaiei?. Iieacaii, ui i?enooi?noue a?ae?ieneaiaoeoo a eiiiiceoe?? c e?ea?nueeith ?a/iaeiith ni?ey? ?? aeoiaeo a oiiaao in vitro oa in vivo. Anoaiiaeaii, ui ?ic?iaeai? iie?o?aoaiia? a?ieia?/ii aeoeai? ?iieaioaoe noeioeththoue i?ioean e?noeiooai?aiiy. Eeth/ia? neiaa: a?iaeano?oeoe?y, a?ae?ieneaiaoeo, eaaai?cie, iie?o?aoaiiaa eiiiiceoe?y, a?ieia?/ia aeoeai?noue, ?aaaia?aoe?y. ANNOTATION Rozhnova R.A. Biologically active implants on base biodegradated polyurethanes. – Manuscript. Thesis for candidate of sciences degree by speciality 02.00.10 – bioorganic chemistry. – The Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine, Kyiv, 1999. The dissertation is devoted to creation of the new polyurethane implants for plastic of bone tissue. The influence of the biologically active fillers in structure of polyurethane compositions on their physical and chemical characteristics in condition in vivo and in vitro was studied. The introduce in structure of the biodegradated polymeric matrix of the hydroxyapatite is established to promote accumulation of the inorganic component of the bone tissue in vivo which is being appearance by basis of the bone formation in regenerating tissue was studied. The presence of hydroxyapatite in composition with remedy substance is shown to promote its yield in conditions in vitro and in vivo. The elaborated polyurethane biologically active implants is established to stimulate the process of bone formation. Key words: biodegradation, hydroxyapatite, levamizole, polyurethane composition, biological activity, regeneration.

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