OA?E?ANUeEEE ?INOEOOO OAeINEIIAEAIIss E?EA??A

II?ICIAA Ieueaa A?eai??aia

OAeE: 616.831-005-036.12-008.9

A?IAIA?AAOE*I? CI?IEI?E O?II?*IEO II?OOAIIssOIICEIAIAI E?IAIIA?AO

14.01.15 – Ia?aia? oai?iae

Aaoi?aoa?aoaeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiyaeieoi?a iaaee/ieo
iaoe

Oa?e?a — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

Iaoeiaee eiinoeueoaio – Caneoaeaiee ae?y/ iaoee Oe?a?ie,Eao?aao
Aea?aeaaii? i?ai?? Oe?a?ie,aeieoi? iaaee/ieo iaoe, i?ioani?Aeoaaiei
?aaai A?eai?iae/,Oa?e?anueeee aea?aeaiee iaaee/iee oi?aa?neoao,caa.
eaoaae?ith ia?aiaeo oai?ia

Io?oe?ei? iiiiaioe: – Caneoaeaiee ae?y/ iaoee ? oaoi?ee
Oe?a?ie,aeieoi? iaaee/ieo iaoe, i?ioani?Aecye Ethaeieea
Aioii?aia,Aei?i?iiao?ianueea iaaee/ia aeaaeai?y,caa. eaoaae?ith
iaa?ieia?? oa iae?io??o?a??

– aeieoi? iaae/ieo iaoe, i?ioani??uaiei Ieoaeei
Ieoaeeiae/,Oa?iii?euenueea iaaee/ia aeaaeai?y,i?ioani? eaoaae?e
iaa?ieia??

– aeieoi? iaae/ieo iaoe, i?ioani?Iaca?aiei Aaaeei
A?eai?iae/,Aeiiaoeueeee iaaee/iee oi?aa?neoao,caa. eaoaae?ith iaa?ieia??

I?ia?aeia onoaiiaa – IAe? aa?iioieia?? AII Oe?a?ie,
a?aeae?eaeno?ai??ai?aeii? iaoieia??, i.Ee?a

Caoeno aeena?oaoe?? a?aeaoaeaoueny “ 9 ” a?oaeiy 1998 ?. i 10 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.609.01 i?e Oa?e?anueeiio
?inoeooo? oaeineiiaeaiiy e?ea??a I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie
ca aae?anith: 310176, i.Oa?e?a, aoe Ei?/aa?ioe?a, 58.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
?inoeoooo oaeineiiaeaiiy e?ea??a (i.Oa?e?a, aoe. Ei?/aa?ioe?a, 58).

Aaoi?aoa?ao ?ic?neaiee 9 eenoiiaaea 1998 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe
?.A.A?eai?iaa33

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeueiinoue i?iaeaie. Noaeeiii caoai?thaaiiy aieiaiiai iiceo
caaaeyee cia/iiio ?iciianthaeaeaiith oa oyaeeei ianeiaeeai noaee
iaeaaaeeeaioith iaaee/iith oa nioeiaeueiith i?iaeaiith ye a iaoie
aea?aeaai, oae i a aieueoinoi aeiiiii/ii ?icaeiooeo e?a?i naioo.

O?iii/ii oi?ie noaeeiii? iaoieiai? aieiaiiai iiceo, yei o aio/eciyiie
eioa?aoo?i aeinoaee iacao aeenoee?eoeyoi?ieo aioeaoaeiiaoie (AeA),
cono?i/athoueny o 20 — 30% ethaeae i?aoeacaeaoiiai aieo (I.A.Aieioei,
1991-1997; E.A.Aecye ci niiaaao., 1996, 1997; A.TH.?oaeaiei, 1997;
I.A.Aa?auaaii, 1997; I.A.Iaiueeianueeee ci niiaao., 1996; I.I.Ea?aaaiue,
1997; ?.A.Oiiaeo, 1985).

I?ia?anoaaiiy o?iii/ii? iiceiai? aeenoee?eoeyoei? i?eaiaeeoue aei
iiaeeaeaiiy iaa?ieiai/iiai aeaoioeeoo, ?icaeoeo noaeeiieo aeaiaioeie,
iiai?oaiiy yeinoi aeeooy oa iiaaeiaeecaoei? oai?eo.

Ca inoaiii aeanyoe?i//y iaeiie/aii /eneaiii aeaii i?i iaoaiicie
oi?ioaaiiy o?iii/ieo ii?ooaiue iiceiaiai e?iaiiaiao (OIIE), ?o eeiii/ii
i?iyae, iniaeeainoi ia?aaiao i?e ?iciie aoeieiai?, oaeoi?e ?eceeo, oeyoe
i?ioieaeoeee i oa?aii? (I.A.Aieioei, A.E.Oaeoee?i, 1991; I.I.Iuaiei ci
niiaaao., 1985-1997; N.I.Aiie/oe, 1996-1997; ?.A.Aeoaaiei, 1989-1997;
A.A.Iaca?aiei, 1995-1997; A.I.Ie?oianueea, 1994-1996; I.A.Aeoaianueea,
1990-1992; I.A.Nei/ie, 1995-1997; I.I.A?eoeae, 1995-1997; I.A.Aeao?ia,
1990-1997; A.Ae.Aeaiaiei, 1996-1997; A.I.Oeieueiee, 1994-1997).

Iacaaaeath/e ia aaeeeo e?euee?noue ?ia?o a?aeiinii OIIE, aeaye? aniaeoe
iaoiaaiaco, ae?aaiinoeee, ia?aa?ao oa e?eoaaiiy o?ii?/ii? iiceiai?
aeenoee?eoeyoe?? iio?aaothoue iiaeaeueoiai aeine?aeaeaiiy. Ianaiia?aae
oea noino?oueny a?iaia?aaoeee, aea/aiiy yei? noaei iaeiith c
iaeaeooaeuei?oeo i?iaeai no/anii? aia?iiaa?ieia??.

Oae, inoaii?i /anii oaaaa ee?i?oeeno?a oa aenia?eiaioaoi??a i?eaa?iooa
aei aeine?aeaeaiiy i?ioean?a iaoaaie?cio a ?oai?ciaai?e ia?aia?e oeaiei?
i?e aino?iio iiceiaiio ?inoeueo? (N.I.A?ie/oe, 1996; I.N.Cicoey ci
niiaaao., 1992; A.I.Canooa, 1996; ?.?.Aon?a c? ni?aaao., 1997;
H.Mochizuki et al., 1990; T.P.Obrenovitch, 1995). Iiyaa no/anieo
iaoiae?a aea/aiiy ii?oiooieoe?iiaeueieo iniaeeainoae aieiaiiai iiceo
c?iaeea iiaeeeaei i?eaeeoo?aa aeine?aeaeaiiy eiai iaoaaie?cio. Ca
aeiiiiiaith iiceo?iiii-ai?n?eii? oiiia?ao?? (I.Garcia et al., 1996) oa
iaai?oii-?aciiainii? niaeo?ineii?? c ?aae?iioee?aeii oinoi?a ?31
(M.Brant-Zawadzki et al., 1997) o oai?eo ia aino?o ?oai?th iiceo a cii?
“iaioia?e” ca?a?no?iaaii cieaeaiiy e?iaiia?ao aiane?aeie ciaioaiiy a i?e
iaoaaie?cio, a ia ?icaeoeo aeaeoeaiiai iae?ico.

Ooiaeaiaioaeueii aiioiii/ii oa iaoioiciieiai/ii aeineiaeaeaiiy
i?aeoaa?aeeee, ui aeeoo?caeaoiinoue aieiaiiai iiceo a ciii ioaii?
caeaaeeoue ia noieueee aiae ii?ooaiue aaiiaeeiaiiee, neieueee aiae
?iceaaeo iaoaaieicio a ioaiiciaaiie oeaieii iiceo (A.I.E?eaeaiianueeee,
1997; C.W.Olanow, 1993; T.Pozzan et al., 1994;). A aenia?eiaioi
anoaiiaeaii, ui aia?aaoe/iee aeaoioeeo, ii?ooaiiy
ieenethaaeueii-aiaeiiaethaaeueieo i?ioeania aiaeia?athoue i?iaiaeio
?ieue o aeaaaia?aoei? oa caaeaaei iae?iiia, a aieiaieie oiiaaie ?icaeoeo
aia?aaoe/iiai aeaoioeeoo ? ianoa/a eenith, ooeiaeaeaiiy iioioiiae?ie, a
yeeo neioacothoueny iae?ia?ai/ii niieoee, oa a?ae noano?aoo ieeneaiiy
aeey iiceo – aetheice (H.Monyer et al., 1992; M.F.Beal et al., 1993;
B.G.Ames et all, 1993).

Aea/aiiy iaoai?ci?a caaeaae? iae?ii?a i?e aino??e ?oai?? oa a?iien??
aeyaeei iaoieia?/io ?ieue iae?io?ainiiooa??a, ianaiia?aae – aethoaiaoo
(I.H.Laake, T.A.Slyngstad, 1995; I.J.Mitchell et all, 1994),
ia?aaaioaaeaiiy iae?iiia Na2+ (I.A.Aaaeiiii, A.A.Oea/oe, 1994;
M.I.Berridge, 1993; M.L.Mayer, R.I.Miller, 1991, R.J.White,
I.J.Reynolds, 1995) oa iineeaiiy i?ioeano ia?aeeniiai ieeneaiiy eiiiaeia
(I.I.Aanaeueneee, 1988-1997; O.C.Ia??nii, 1981; I.A.A?eai?iaa, 1997; T.
Funahashi et all, 1994).

I?e/iio iacaai? iaoiaaiaoe/i? eaioethae o?nii iia’ycai? c aia?aaoe/iei
iaoaaie?ciii, ui aeaco? ia i?ia?aeio ?ieue aia?aaoe/iiai caaacia/aiiy a
ooieoe?iioaaii? ia?aiaeo ee?oei (T.M.Dawson et al., 1992; F.Zhang et
al., 1993; P.Ienner. 1994; D.I.Hoffman et al., 1994; R.I.Whit et al.,
1995). Oiaoi aeine?aeaeaiiy a?iaia?aaoeee iathoue aaaeeeaa cia/aiiy ia
o?eueee aeey ooi/iaiiy iaoai?ci?a caaeaae? iae?ii?a i?e
oea?aa?iaaneoey?i?e iaoieia??, aea e aeey iiaeaeueoiai ?icaeoeo
eiioeaioe?? iae?ii?ioaeoe??.

Iaeiae aieueoinoue ?iaio uiaei aiiaia?aaoeee i?e oea?aa?aeueiie
iaoieiai? iineoue aenia?eiaioaeueiee oa?aeoa? aai noino?oueny aino?eo
ii?ooaiue iiceiaiai e?iaiiaiao. Aeineiaeaeaiiy aiiaia?aaoe/iiai
aiiainoaco i?e o?iii/iie iiceiaie aeenoee?eoeyoei? iaei/eneaiii,
oi?eathoueny eiai ie?aieo noi?ii i ia ae?ioothoue i?iaeaio a oeieiio.
Aeinueiaiaeii ia aeinoaee oaeiae iaeaaeiiai aenaioeaiiy
aiiaia?aaoe/ii-aaaaoaoeaii niiaaiaeiioaiiy, ui aaaeooue aei ?icaeoeo
iiceiai? aeenoee?eoeyoei?. Aaaeeeaei ? ? aea/aiiy iniaeeainoae
ooieoeiiioaaiiy aaaaoaoeaii? ia?aiai? nenoaie i?e OIIE, aa?o/e aei oaaae
?? oiiaa?naeueio o/anoue o ?aaoeyoei? aiiainoaco (I.I.Aaei ci niiaaao.,
1981-1997), a oiio /enei aia?aaoe/iiai iaoaaieicio.

Oaeei /eiii, i?iaeaia oi?ioaaiiy aioeaoaeiiaoie oianeiaeie o?iii/ii?
iiceiai? aeenoee?eoeyoei? c iiceoeie ii?ooaiue aiiaia?aaoeee, ca’yceo
oeeo ii?ooaiue ?c ?iceaaeii a ieneaeaioii-aioeieneaeaioiie,
iae?iaoii?aeueiie nenoaiao oa aaaaoaoeaiith aeec?aaoeyoei?th ia
?icaeyaeaeany. A aiia ? aaaeeeaith e ia?niaeoeaiith aianeiaeie iiaeo
iiaeeeainoae oa?aiaaoe/ii? ei?aeoei? aaea aeieeeeo eeiii/ieo i?iyaia, a
aieiaia – i?ioieaeoeee ?icaeoeo iaa?ieiai/iiai aeaoioeeoo.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoeiy
aeeiiaia aiaeiiaiaeii aei aea?aeaaieo eiiieaenieo iiaeaiaeii/eo i?ia?ai
«I?ioieaeoeea caoai?thaaiue i oi?ioaaiiy caei?iaiai niiniao aeeooy
ianaeaiiy Oe?a?ie ia ia?iiae aei 2000 ?ieo» i aiaeii/i? i?ia?aie
«Noaeeiii caoai?thaaiiy aieiaiiai iiceo», ieaio iaoeiaeo aeineiaeaeaiue
Oa?eianueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo “Aea/aiiy caaaeueieo
caeiiiii?iinoae iaoiaaiaoe/ieo i?ioeania oa ?ic?iaea niiniaia ?o
ei?aeoei?” oa a ?onei iaoeiai-aeineiaeii? ?iaioe eaoaae?e ia?aiaeo
oai?ia OAeIO «Iaoaiicie oi?ioaaiiy o?iii/ieo ii?ooaiue iiceiaiai
e?iaiiaiao» (N aea?ae?a?no?aoei? 01950023465).

Iaoa aeineiaeaeaiiy. Anoaiiaeaiiy ?iei ii?ooaiue aiiaia?aaoe/iiai oa
iae?iaoii?aeueii-aaaaoaoeaiiai aiiainoaco a oi?ioaaiii o?iii/ii?
iiceiai? aeenoee?eoeyoei? oa iniaeeainoae ?? ia?aaiao i?e a?oa?iaeueiie
aiia?oaici?, aoa?ineea?ici i ?o ii?aeiaii?, a oaeiae ?ic?iaea iaoiaeia
ia?aeiii? i aoi?eiii? i?ioieaeoeee oa eieoaaiiy a caeaaeiinoi aiae noaio
aia?aaoe/iiai iaoaaieicio.

Iniiaii caaaeaiiy ?iaioe:

1. Aea/eoe iniaeeainoi aiiaia?aaoeee o oai?eo ia o?iii/io iiceiao
aeenoee?eoeyoeith (ieenethaaeueiiai oinoi?eethaaiiy, iaioiciiai oeeeeo
oa aiaa?iaiiai aeieieico) oa ioeiieoe ?o o caeaaeiinoi aiae eeiii/ii?
noaaei? aeenoee?eoeyoi?ii? aioeaoaeiiaoi?, aoeieiai? aeenoee?eoeyoei?,
noaio oeaio?aeueii? oa oea?aa?aeueii? aaiiaeeiaiiee, no?oeoo?ieo oa
ooieoeiiiaeueieo noaiia aieiaiiai iiceo.

2. I?iaanoe aenia?eiaioaeueia aeineiaeaeaiiy aia?aaoe/iiai iaoaaieicio
i?e iiaeaeueiiio aoa?ineea?ici c aecia/aiiyi aeoeaiinoi
iioioiiae?iaeueieo, aeieieioe/ieo oa?iaioia, Na-AOOace, ??aiy
aioo?ioiueieeioeiiiai eaeueoe?th oa i?ioeania IIE.

3. Ioeiieoe aiiaia?aaoe/ii iieacieee a caeaaeiinoi aiae noaio
ieneaeaioii-aioeieneaeaioieo nenoai, eiiiaeiiai iaiiio, ?iaiy aiiaaiieo
iiiiaiiiia, iae?iiaaeiaoi?ieo aiiiieeneio, i?inoaoeeeeii-o?iiaienaiiaiai
niiaaiaeiioaiiy oa nooiaiy aaaaoaoeaii? aeenooieoei?.

4. Aeyaeoe ?ieue aiiaia?aaoe/ii-iae?iaoii?aeueieo niiaaiaeiioaiue oa
iniaeeainoae aaaaoaoeaii? ?aaoeyoei? a oi?ioaaiii eeiii/ieo neiae?iiia.

5. Ia iiaenoaai aecia/aiiy iniaeeainoae aiiaia?aaoe/iiai oa
aaaaoaoeaiiai aiiainoaco o ethaeae c iniiaieie oaeoi?aie ?eceeo
oea?aa?i-aaneoey?ii? iaoieiai? oa aeaieo i?iniaeoeaiiai niinoa?aaeaiiy
ca oai?eie c ?icieie aa?iaioaie aiiaia?aaoe/ii-aaaaoaoeaieo
niiaaiaeiioaiue aeiaanoe iiaeeea?noue i?iaiicoaaiiy ia?aaiao o?iii/ieo
ii?ooaiue iiceiaiai e?iaiiaiao.

6. Aea/eoe iiaeeeainoi ia?aeiii? i aoi?eiii? i?ioieaeoeee o?iii/ii?
iiceiai? aeenoee?eoeyoei? oa ?ic?iaeoe noaie iaoiaaiaoe/iiai eieoaaiiy
AeA c a?aooaaiiyi iieacieeia aiiaia?aaoe/iiai, aaaaoaoeaiiai i
iae?iaoii?aeueiiai aiiainoaco.

Iaoeiaa iiaecia io?eiaieo ?acoeueoaoia. O ?iaioi aia?oa eiiieaenii a
eeiiioei oa aenia?eiaioi aeineiaeaeaia ?ieue aiiaia?aaoe/ieo ciii o
oi?ioaaiii oa ia?aaiaiai o?iii/ieo ii?ooaiue iiceiaiai e?iaiiaiao.
Anoaiiaeaii, ui iaoiaaiaoe/iei iaoaiiciii ?icaeoeo aioeaoaeiiaoi? i?e
o?iii/iie iiceiaie aeenoee?eoeyoei? ? aia?aaoe/iee aeaoioeeo, yeee
iia’ycaiee ic cieaeaiiyi aeoeaiinoi iioioiiae?iaeueieo oa?iaioia i
i?eaii/aiiyi i?ioeania ieenethaaeueiiai oinoi?eethaaiiy a iioioiiae?iyo
aianeiaeie aiiieni? a oiiaao ii?ooaiiy aaiiaeeiaiiee, iniaeeai a
iie?ioee?eoeyoi?iiio ?onei. Aeyaeaii niieo/aiiy cieaeaii?
aia?aicaaacia/aiiinoi c iaia?aiiith iaoieiai?th o aeaeyaei ciii
no?oeoo?iiai ?iciiaeieo o?aeoeie oinoieiiiaeia, i?aeaeuaiiyi aeoeaiino?
ia?ea?ieo iaia?aiica’ycaieo oa?iaio?a, a oaeiae iaeiie/aiiyi
aioo?ioiueieeioeiiiai eaeueoeith i iineeaiiyi i?ioeania IIE.
Anoaiiaeaiee ca’ycie aiiaia?aaoe/ieo ciii c iaoieiai/ieie c?ooaiiyie a
nenoaiao iae?iiaaeiaoi?ieo aiiiieeneio, i?inoaii?aeia oa aiiaaiieo
iiiiaiiiia. I?iaiaeiciaaii iniaeeainoi aiiaia?aaoeee a caeaaeiinoi aiae
ae?aaeaiinoi no?oeoo?ieo ciii aieiaiiai iiceo. Anoaiiaeaii, ui
iaecia/iioee aia?aaoe/iee aeaoioeeo ?icaeaa?oueny i?e aeeoociie
iaoieiai? aieiaiiai iiceo o aeaeyae? /eneaiieo ae??aiiina?aaeeiaeo
?ioa?eo?a oa eaeeia?aico.

Iieacaii, ui ia ii/aoeiaie noaaei? OIIE ?icaeaathoueny aaeaioeaii
c?ooaiiy, yei iieyaathoue o iineeaiii aiaa?iaiiai aeieieico, c?inoaiii
aioeieneaeaioii? aeoeaiinoi, iiaeaeuaiii ?iaiy iae?iiaaeiaoi?ieo
aiiiieeneio, a oaeiae aaaaoaoeaiie a?aio?iiiie aeoeaaoei?. Iiaeaeueoa
i?ia?anoaaiiy OIIE iia’ycaia c aeacaaeaioeaieie c?ooaiiyie, ?acoeueoaoii
yeeo ? cieaeaiiy aaaaoaoeaiiai caaacia/aiiy aiiaieiiaoe/ieo i?ioeania,
iineeaiiy IIE, iiaeeaeaiiy iaia?aiii? iaoieiai?, i?eaii/aiiy anio
oeeeeia aia?aaoe/iiai iaoaaieicio, ui iineeth? aia?aaoe/iee aeaoioeeo.

Oia?oa ia iiaenoaai i’yoe-ainueie?i/iiai i?iniaeoeaiiai aeineiaeaeaiiy
oai?eo ia o?iii/io iiceiao aeenoee?eoeyoeith iiaeoaa?aeaeaia ?ieue
ii?ooaiue aiiaia?aaoeee oa ?? ?aaoeyoei? c aieo aaaaoaoeaii? ia?aiai?
nenoaie a ?icaeoeo oa i?ia?anoaaiii OIIE. Aeyaeaii iaeni?eyoeeaioi oa
iaeiani?eyoeeaioi uiaei ?icaeoeo aeenoee?eoeyoi?ii? aioeaoaeiiaoi? oeie
aaaaoaoeaii? ?aaoeyoei? i aiiaia?aaoe/ii-iae?iaoii?aeueii-aaaaoaoeaieo
niiaaiaeiioaiue.

Aeyaeaia iiaeeeainoue aaeueioaaiiy i?ioeania o?iii/ii? iiceiai?
aeenoee?eoeyoei? oeyoii aieeao ia aiiaia?aaoe/ii oa aaaaoaoeaii
iieacieee. Aeiaaaeaii iiina?aaeeiaaio aeith oa?aii?, ui ?aaoeth?
aiiaia?aaoe/ii i?ioeane, ia noai oea?aa?aeueii? aaiiaeeiaiiee.

Oia?oa aea/aii eeiiiei-aiiaia?aaoe/ii niiaaiaeiioaiiy, ui aeicaieeei
aecia/eoe ?ieue a?iaia?aaoe/ieo ci?i o oi?ioaaii? ee?i?/ii?
iaa?ieia?/ii? nai?ieia??. Iieacaii, ui iniae c iniiaieie oaeoi?aie
?eceeo oea?aa?iaaneoey?ii? iaoieiai? aac eeiii/ieo i?iyaia caoai?thaaiiy
iathoue aiaeiiiiee aiae caei?iaeo oei aaaaoaoeaii? ?aaoeyoei? oa
aiiaia?aaoe/iiai aiiainoaco.

I?aeoe/ia cia/aiiy ?iaioe. Ia iniiai io?eiaieo ?acoeueoaoia
aeineiaeaeaiiy aeiaaaeaia iiaeeea?noue i?iaiicoaaiiy ?icaeoeo OIIE a
caeaaeiinoi aiae oeio aaaaoaoeaii-aiiaia?aaoe/ieo niiaaiaeiioaiue, ui
aeicaieeoue iaoiaaiaoe/ii iaa?oioiaaii i?iaiaeeoe i?ioieaeoeeo o?iii/ii?
iiceiai? aeenoee?eoeyoei?. Aeyaeaii ca’ycee iiae niaeo?aie iiooaeiinoae
iniiaieo aiiaeaeo?e/ieo ?eoiia ii aeaieo AAA oa nooiaiai aia?aaoe/iiai
aeaoioeeoo, ui aeicaieeoue oaeineiiaeeoe ?aiith aeiaaiinoeeo ii?ooaiue
aia?aaoe/iiai iaoaaieicio i?e OIIE oa eiio?iethaaoe aoaeoeaiinoue
oa?aiaaoe/ieo caoiaeia.

Iieacaia aeioeieueiinoue oa aei?ainoue ia?aeiii? oa aoi?eiii?
i?ioieaeoeee OIIE ia iniiai ei?aeoei? aiiaia?aaoe/ieo ciii.

?acoeueoaoe aeineiaeaeaiue aeiaaee, ui aeey i?ioieaeoeee aia?aaoe/iiai
aeenaaeaino i caioneo aiiaia?aaoe/ieo iaoaiiciia ?icaeoeo oea?aa?aeueii?
aeenoee?eoeyoei? o inia c oaeoi?aie ?eceeo oea?aa?i-aaneoey?ii?
iaoieiai? iio?iaai eiiieaen caoiaeia, yeee aeeth/a? aaeaeaaoiee ?ooiaee
?aaeei, ieneaaiioa?aiith, ineoioa?aiaaoe/ii, ?aoeaeoi?ii aei?,
naaeaoeaii, aaaaoio?iiii, AAIE-a?ai/ii i?aia?aoe, aaeaioiaaie oa
aeoeaaoi?e aiiaia?aaoe/ieo i?ioeania.

A caeaaeiinoi aiae iniaeeainoae ii?ooaiue aiiaia?aaoeee ?ic?iaeaii
noaie iaoiaaiaoe/iiai eieoaaiiy ia eiaeiie noaaei? aeenoee?eoeyoi?ii?
aioeaoaeiiaoi?. Aeiaaaeaia iae?ii?ioaeoi?ia oa aaciaeoeaia aeiy
i?aia?aoia-aeoeaaoi?ia iaoaaiei/ieo i?ioeania. ?acii c oei, aeyaeaiee
aeoeaoth/ee aieea iiiioa?aii? aeacaieie i?aia?aoaie ia i?ioeane
aieueii-?aaeeeaeueiiai ieeneaiiy, iniaeeai o oai?eo c ae?aaeaiith
iiceiaith aeenoee?eoeyoei?th. Oea naiae/eoue i?i iaiaoiaeiinoue
canoinoaaiiy aeoeaaoi?ia iaoaaiei/ieo i?ioeania oieueee a niieo/aiii c
iaia?aiii?ioaeoi?aie o aeaeyaei i?aia?ao?a aioeieneaeaioii? ae??.

?ic?iaeaia iaoiaeeea ei?aeoei? aiiaia?aaoe/ieo ciii o oai?eo ia OIIE c
aeei?enoaiiyi iecueeiiioaineaiiai eaca?iiai ii?iiiithaaiiy oa
anoaiiaeaia ?? iae?ii?ioaeoi?ia aeiy.

Aeiaaaeaii, ui eiiieaen i?ioieaeoe/ieo oa eieoaaeueieo caoiaeia iiaeiai
oaeiae a?aoiaoaaoe oei aaaaoaoeaii? aeec?aaoeyoei?, iia’ycaiee c
iniaeeainoyie ?icaeoeo ?icieo aa?iaioia aeenoee?eoeyoei?. I?e
ia?iaiaioiiio oeiiai ia?aaiao neiae?iio aaaaoaoeaii? aeenoiii? iniaeeaa
oaaaa iiaeiia aooe caa?iaia ia eiiiaeiee niaeo? e?iai, aiiieiiiaeaii/ii
i?aia?aoe oa aioeieneaeaioe. I?e ia?ieneciaeueiiio c /anoeie
aaaaoaoeaiei e?ecaie – ia AAIE-a?ai/ii i?aia?aoe, ae?oeei,
o?aieaieicaoi?e, aeieaoi?e aaoa-aae?aia?ai/ieo ?aoeaioi?ia oa iiaiaioi?e
IAI.

?acoeueoaoe aeineiaeaeaiue ai?iaaaeaeaii a ?iaioo iaa?ieiai/ieo
aiaeaeieaiue Oa?eianueei? oa Iieoaanueei? iaeanieo eeiii/ieo eiea?aiue,
iinueeeo eiea?aiue i.Oa?eiaa, oeaio?aeueieo ?aeiiieo eiea?aiue
Oa?eianueei? iaeano?, a oaeiae o iaa/aeueiee i?ioean eaoaae? ia?aiaeo
oai?ia Oa?eianueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo oa
Oa?eianueeiai iinoeoooo aaeineiiaeaiiy eiea?ia.

Iniaenoee aianie o ?ic?iaeo iaoeiaeo ?acoeueoaoia. Aaoi?ii naiinoieii
i?iaaaeaii eeiii/ia, aiioiii/ia, ineoieiai/ia aeineiaeaeaiiy oai?eo ia
OIIE oa aiia?oiii/io oai?iao, a oaeiae ocyoa o/anoue a
aenia?eiaioaeueieo aeineiaeaeaiiyo oaa?ei c iiaeaeueiei aoa?ineea?icii.
Aeey oiioieaoei? ?acoeueoaoia aeineiaeaeaiue oa eiii’thoa?ii? ia?iaee
iioi?iaoei? ?ic?iaeaia i?ia?aia aeiaaiinoeee oa aeeoa?aioeieii?
aeiaaiinoeee AeA. Caeieniaii aiaeic aiiaia?aaoe/ieo, iae?iaoii?aeueieo
oa aaaaoaoeaieo ii?ooaiue o caeaaeiinoi aiae noaaei? aeenoee?eoeyoi?ii?
aioeaoaeiiaoi?, aaiiaeeiaii/ieo iieacieeia, no?oeoo?ieo oa
ooieoeiiiaeueieo ciii aieiaiiai iiceo i eeiii/ieo neiae?iiia
caoai?thaaiiy. I?iaaaeaia oa?aiaaoe/ia ei?aeoeiy iaoaaiei/ieo ?iceaaeia
c ii?iaiyeueiei aiaeicii aoaeoeaiinoi iaaeeeaiaioicii? oa
iaiaaeeeaiaioicii? oa?aii? oa i?iniaeoeaia niinoa?aaeaiiy ca oai?eie c
?icieie aa?iaioaie aaaaoaoeaii? ?aaoeyoei? i?ioyaii 5-8 ?ieia.

Ai?iaaoeiy ?iaioe. ?acoeueoaoe i?iaaaeaieo aeineiaeaeaiue iiaiaeiieaii
oa iaaiai?aii ia I c’?caei aa?iioieiaia i aa?iao?ia Oe?a?ie
(Aeiii?iiao?ianuee, 1988); V Ananithciiio c’?caei aa?iioieiaia i
aa?iao?ia (Oaieini, 1988); VIII c’?caei iaa?iiaoieiaia, ineoiao?ia i
ia?eieiaia Oe?a?ie (Oa?eia, 1990); Anaoe?a?inueeie eiioa?aioei?
«Iaiaaeeeaiaioicii iaoiaee eieoaaiiy» (Oa?eia, 1991); iiaeia?iaeiie
eiioa?aioei? «Eiii’thoa?: oaoiiea, oaoiieiaiy oa caei?ia’y» (Oa?eia,
1995); iiaeia?iaeiie iaoeiai-i?aeoe/iie eiioa?aioei? «Ethaenueeee oaeoi?
o ieoaiiyo aaciaee» (Oa?eia, 1996); I Iaoeiiiaeueiiio Eiia?ani
iaa?ieiaia, ineoiao?ia i ia?eieiaia Oe?a?ie (Oa?eia, 1997); II
iiaeia?iaeiiio eiia?ani c iioaa?aoeaii? aio?iiieiai? (Aiiieoey, 1998);
ia ?aaiiiaeueieo, iaeanieo, iinueeeo iaoeiai-i?aeoe/ieo eiioa?aioeiyo,
caniaeaiiyo Oa?eianueeiai iaeaniiai oiaa?enoaa iaa?ieiaia (1988-1998).

Ioaeieaoei?. Iniiaii iieiaeaiiy aeena?oaoei? iioaeieiaaii a 35
ae?oeiaaieo ?iaioao, c ieo 15 o oaoiaeo iaoeiaeo aeaeaiiyo, c yeeo 10
naiinoieieo.

No?oeoo?a oa ianya aeena?oaoei??. Aeena?oaoeiy aeeeaaeaia ia 465
noi?iieao iaoeiiieniiai oaenoo i neeaaea?oueny ic anooio, iaeyaeo
eioa?aoo?e, naie ?icaeieia aeanieo aeineiaeaeaiue, caeeth/ii? /anoeie,
aeniiaeia, i?aeoe/ieo ?aeiiaiaeaoeie oa aeiaeaoeia. ?iaioa iethno?iaaia
73 oaaeeoeyie, 35 ?enoieaie oa eeiii/ieie i?eeeaaeaie. Nienie
aeei?enoaii? eioa?aoo?e neeaaea?oueny c 459 aeaea?ae, c yeeo 276
a?o/eciyieo oa e?a?i aeeaeiueiai ca?oa?aeaey ? 183 iiicaiieo.

CIINO ?IAIOE

Caaaeueia oa?aeoa?enoeea niinoa?aaeaiue i iaoiaee aeineiaeaeaiiy.

Iniiaith aeena?oaoeieii? ?iaioe iineoaeeee iaoa?iaee eiiieaeniiai
ianoaaeaiiy 803 oai?eo, yei a caeaaeiinoi aiae caaaeaiue aeineiaeaeaiiy
aoee ?iciiaeieaii ia aeaeieueea a?oi: 1) aeey anoaiiaeaiiy iniaeeainoae
aiiaia?aaoe/iiai, iae?iaoii?aeueiiai oa aaaaoaoeaiiai aiiainoaco
aeineiaeaeaii 299 iaoei?ioia AeA ?iciiai aaiaco i noaaeie (caiaeii c
eeaneoieaoei?th N.A.Oiiaeoa,1985); 2) aeey aea/aiiy iaoaiiciia aieeao
aaaaoaoeaii? ia?aiai? nenoaie ia ia?aaia a?ia?oii?/ii? oai?iae (AO) i
oi?ioaaiiy OIIE i?e a?oa?iaeueiie aiia?oaici? (AA) ianoaaeaii 258
iaoei?ioia, c yeeo 99 oai?eo ia a?aie/io a?oa??aeueio a?ia?oaic?th
(/ieiaiee aieii aiae 18 aei 36 ?ieia); 78 — ia AO 1 no.(/ieiaiee aieii
aiae 28 aei 45 ?ieia); 81 – ia AO II no. (/ieiaiee aieii aiae 43 aei 58
?ieia) caiaeii c eeaneoieaoei?th AIIC (1996); a?oio ii?iaiyiiy neeaee 75
i?aeoe/ii caei?iaeo /ieiaieia aiaeiiaiaeiiai aieo; 3) aeey aecia/aiiy
iaeaieueo ni?eyoeeaeo oa iani?eyoeeaeo oeiia aaaaoaoeaii? ?aaoeyoei?,
aiiaia?aaoe/ii-aaaaoaoeaieo i aiiaia?aaoe/ii-iae?iaoii?aeueieo
niiaaiaeiioaiue i?iaaaeaia i?iniaeoeaia niinoa?aaeaiiy i?ioyaii 5-8
?ieia ca 246 oai?eie, ui no?aaeaeaee ia neiae?ii aaaaoaoeaii? aeenoiii?
?iciiai aaiaco: eiinoeoooeieii coiiaeaiee (41 iaoeicio), yeee aeiee ia
oei aiioeieiiai no?ano (67 iaoei?ioia) /e OIIE (138 iaoei?ioia); 4)
iniaeeainoi aiiaia?aaoeee oa aaaaoaoeaii-iae?iaoii?aeueieo
niiaaiaeiioaiue aeineiaeaeaii o 293 inia c iniiaieie oaeoi?aie ?eceeo
oea?aa?iaaneoey?ii? iaoieiai? (aeeneiiii?ioa?iaii?th, niaaeeiainoth,
iaoyaeaiith na?oeaai-noaeeiieie caoai?thaaiiyie, aiiiaeeiaii?th) aac
eeiii/ieo i?iyaia caoai?thaaiiy. A oei eeiii/ii a?oie aaieoee /ieiaiee o
aioei aiae 17 aei 30 ?ieia (75, 85 i 41 aiaeiiaiaeii); ianoaaeaii oaeiae
35 inia, yei aaee aeoeaiee niinia aeeooy (aieii aiae 19 aei 30 ?ieia) oa
54 iniae oiai ae aieo, ui caciaaaee o?iii/iiai aiioeieiiai no?ano. Oei
a?oie aoee noi?iiaaii a i?ioeani aiiaeaiiieiai/ieo aeineiaeaeaiue, yei
i?iaiaeeeenue IAeI oa?aii? ii. I.Ae.No?aaeanea ia aaeeeeo eiioeiaaioao
nooaeaioia oa?eianueeeo AOCia, iaoeiaeo i?aoeiaieeia IAeI, a oaeiae i?e
ne?eiiiaiai aiaee?eoi? /ieiai/i? iiioeyoei? 20-54 ?ieia o
Aeca?aeeinueeiio ?aeiii i.Oa?eiaa.

Aenia?eiaioaeueiee aoa?ineea?ic aiaeoai?thaaany ia 20 noaoaai c?ieeo
e?ieeeao-naioeyo ii?iaee Oeioeea c aeei?enoaiiyi caaaeueiii?eeiyoi?
oieanoa?eiiai? iiaeae? (I.I.Aii/eia, A.I.Eeeiia,1976). Eiio?ieueio a?oio
neeaee 12 ?ioaeoieo oaa?ei.

Iaoiaeeee aeineiaeaeaiiy, yei aeei?enoiaoaaeeny a aeaiie ?iaioi,
aeioeieueii ?iciiaeieeoe ia /ioe?e a?oie.

Ia?oa a?oia aeicaieeea aa?eoieoaaoe AeA ca aeiiiiiaith eeiii/iiai
ianoaaeaiiy c aeei?enoaiiyi niaoeiaeueii ?ic?iaeaieo ea?o i
eiii’thoa?ii? i?ia?aie aeiaaiinoeee, iino?oiaioaeueieo aeineiaeaeaiue
aaiiaeeiaiiee oa aecia/aiiy no?oeoo?ii-ooieoeiiiaeueieo oa?aeoa?enoee
aieiaiiai iiceo. Noai oea?aa?aeueii? aaiiaeeiaiiee ioeiithaaany
?aaeiiioeeiaeieie oa oeueo?acaoeiaeie iaoiaeeeaie. Niiaaiaeiioaiiy
oaeaeeinoae eiiieiiai iiceiaiai e?iaioieo a a?oa?iaeueiiio i aaiiciiio
?onei, a oaeiae caaaeueiee /an oea?aa?aeueiiai e?iaioieo aecia/aee ca
aeiiiiiaith ?aaeiioee?eoeiaioeaoaeia?ai (?OeAA) ia o?eeaiaeueiiio
?aaeiia?aoi «Aaiia» (OI?) c aeei?enoaiiyi iaoaiaoe/ii? ia?iaee
(I.I.Ieeeiaiei, I.A.Aieioei c niiaaao.,1984). Ioeiieo e?iaioieo a
ie?aieo iiceiaeo a?oa?iyo i?iaiaeeee c aeei?enoaiiyi aeno?a- oa
o?aine?aiiaeueii? aeiiea?ia?aoi? (OEAe) ia aia?aoi «Sonodop-8000» oi?ie
Sonotechnik (Iiia//eia). Oeaio?aeueia aaiiaeeiaiiea aea/aeany ca aeaieie
oao?aiiey?ii? a?oaeii? ?aia?aoi? ia aeaieaiaeueiiio ?aiieaoeciia?aoi
?IA2-02 (C.Kubicek,1966; TH.O.Iooea?ue,1977). Oea?aa?aeueia
iae?iaeeiaiiea aea/aeany ca aeiiiiiaith aicoaeueiiai aiaeico AAA, a
oaeiae oiiinaeaeoeaiiai ea?ooaaiiy ia 16-eaiaeueiiio
aeaeo?iaioeaoaeia?aoi c aeei?enoaiiyi i?ia?aie «Neurotools». Aeey
aicoaeicaoei? no?oeoo?ieo ciii aieiaiiai iiceo aeei?enoiaoaaany iaoiae
eiii’thoa?ii? oa iaaiioii-?aciiainii? oiiia?aoi? ca aeiiiiiaith EO ST
MAX General Electric Med. Syst, ? I?O “Ia?ac — 1”.

Ae?oaa a?oia iaoiaeee aeicaieeea ioeiieoe aiiaia?aaoe/iee aiiainoac o
oai?eo ia OIIE oa a aenia?eiaioaeueieo oaa?ei. Noai ieenethaaeueiiai
oinoi?eethaaiiy oa caaacia/aiinoue aia?ai?th o iaoei?ioia ioeiithaaeeny
ca aiinoii aaeaiieiaeo ioeeaioeaeia a ia?eoa?e/i?e e?iai iaoiaeii
oiieioa?iai? o?iiaoia?aoi? (?.A.sseooaaa, E.?.I?eiaa, 1974). Aeey
ioeiiee noaio iaoaaieicio a iaioicioinoaoiiio oeeeei ia?aoai?aiiy
aetheice aea/aeanue aeoeaiinoue aetheici-6-oinoaoaeaaiae?iaaiace
(A-6-OAeA) niaeo?ioioiiao?e/iei niiniaii. I?i iioaineaiinoue i?ioeania
aiaa?iaiiai aeieieico noaeeee ia iiaenoaai aeoeaiinoi eeth/iaiai
oa?iaioo – eaeoaoaeaaiae?iaaiace (EAeA), a oaeiae oa?iaioia aeueaeieace
(AAe), oinoio?oeoieiiace (OOE), aaenieiiace (AE) a ieacii e?iai oa
a?eo?ioeeoao ca aeiaeaieie oiioieiaaieie iino?oeoeiyie. Icioa?iaioiee
niaeo? EAeA aea/aany iaoiaeii aeaeo?ioi?aco a aaa?iciiio aaeaai
(I.A.Aa?iai ci niiaaao.,1982). sse iieaciee aiiieni? aecia/aany aiino o
ne?iaaooei e?iai eiioeaaiai i?iaeoeoo aeieieico – eaeoaoo oa i?iiiaeiiai
i?iaeoeoo – ii?oaaoo ca aiceiaoe/ieie iaoiaeeeaie, iienaieie
I.I.I?ioi?iaith (1982). ?iaaiue aetheice a ne?iaaooei e?iai aecia/aany
noaiaea?oiei niiniaii. Noai ieneaeaioii? i aioeieneaeaioii? nenoai
ioeiithaaany ca iieacieeaie aiinoo aei?iiaeo eii’thaaoia (AeE),
iaeiiiaiai aeiaeueaeaaiaeo (IAeA), SH-a?oi, aeooaoiiio, eaoaeace (Ea),
ia?ieneaeace (I), yei aecia/aeeny noaiaea?oieie aiioiii/ieie
iaoiaeeeaie. ?iaaiue oinoieiiiaeieo o?aeoeie iaia?ai a?eo?ioeeoia
aecia/aany ca iaoiaeii aeaiii?ii? o?iiaoia?aoi? c ?o iaeaioeoieaoei?th
ca noaioa?oieie aecia/ieeaie. Aecia/aiiy ??aiy ia?ea?ieo
iaia?aiica’ycaieo oa?iaio?a i?iaiaeeeiny ca aeiaeaieie oi?o?eiaaieie
?ino?oeoe?yie. Aeey oa?aeoa?enoeee aia?aaoe/iiai iaiiio a aieiaiiio
iiceo aenia?eiaioaeueieo oaa?ei aea/aeenue iioioiiae?iaeueii oa?iaioe
oeeeeo o?eea?aiiiaeo eeneio: noeoeeiaoaeaaiae?iaaiaca (NAeA),
aeueoa-eaoiaeooa?aoaeaaiae?iaaiaca, oeeo?aoneioaca oa
aeooaiaoaeaaiae?iaaiaca (aeooaiao-AeA) niaeo?ioioiiao?e/iei iaoiaeii
(I.I.I?ioi?iaa,1982), oa?iaioe aiaa?iaiiai aeieieico (AAe, EAeA, OOE,
AE) oa aiino eaeoaoo i ii?oaaoo a ei?i aaeeeeo iiaeoeue, aiiioaeaioni,
noiaao?i iiceo, a oaeiae o ne?iaaooei, ieacii i a?eo?ioeeoao e?iai
aecia/aee oioieiei?eiao?e/iei iaoiaeii (A.N.Anaoiaii,1969). Aiino
i?iaeoeoia IIE o oeaieii iiceo aea/aee niaeo?ioioiiao?e/ii (A.I.I?aoia,
1978). Aecia/aiiy aeoeaiino? Na-AOOace i?oioiiae??e i?iaiaeeee
oioieiei?eiao?e/iei niiniaii.

O?aoy a?oia iaoiaeee ioeiithaaea noai iae?iaoii?aeueieo nenoai ia iniiai
aecia/aiiy a ieacii e?iai aiinoo i?inoaii?aeia (noaaieueiiai iaoaaieioo
i?inoaoeeeeiio 6-eaoi-IAF1, noaaieueiiai iaoaaieioo o?iiaienaio A2
Tx-B2, i?inoaaeaiaeeiia IAA1 , IAF2 ) ?aaeiiiioiieiai/iei iaoiaeii.
Aeiaiaa aene?aoeiy c ii/ith aae?aiaeiio (A) oa ii?aae?aiaeiio (IA)
aea/aeany niaeo?ioethi?ia?aoi/iei iaoiaeii (I.O.Iaoeiia,1976). ?iaii
iae?iiaaeiaoi?ieo aiiiieeneio, aiiaaiieo iiiiaiiiia oa ?oiio
iiia?aaeieeia aecia/aeeny iaoiaeii iiiiiaiiiii? i eieiieiai?
o?iiaoia?aoi? c aiaeicii ?oiio niaeo?ia ca eaeia?iai/ieie e?eaeie.

Ieaciiai iieacieee eiiiaeiiai iaiiio: caaaeueiee oieanoa?ei (ON),
o?eaeioea?eaee (OA), ON eiiii?ioa?aeia iecueei? aonoeie (ONEIIA), ON
eiiii?ioa?aeia aeniei? aonoeie (ONEIAA) aecia/aeeny c aeei?enoaiiyi
oa?iaioieo iaai?ia ca aeiaeaieie iino?oeoeiyie; aeey aecia/aiiy
niiaaiaeiioaiiy ?icieo eeania EI ?ic?aoiaoaaee eiaoioei?io aoa?iaaiiinoi
(EA) ca A.I.Eeiiiaei (1984).

*aoaa?oa a?oia iaoiaeee aeei?enoiaoaaeany aeey aecia/aiiy iniaeeainoae
aaaaoaoeaii? ?aaoeyoei?. Aeineiaeaeoaaeeny noa’?eoeaii e ia’?eoeaii
aaaaoaoeaii neiioiie ca niaoeiaeueieie noaiaie, a oaeiae aaaaoaoeaiee
oiion, aaaaoaoeaia ?aaeoeaiinoue (A?), aaaaoaoeaia caaacia/aiiy
oice/ii?, ?icoiiai? oa aiioeieii? aeiyeueiinoi (ACAe) (I.I.Aaei ci
niiaaao.,1991). E?ii oiai, aaaaoaoeaii ooieoei? ioeiithaaeeny ca
iaoiaeii aa?iaoeieii? iioa?aaeiiao?i? (?.I.Aa?anueeee, 1988).

Noaoenoe/ia ia?iaea ?acoeueoaoia aeineiaeaeaiiy i?iaaaeaia ca
aeiiiiiaith no/anieo iaoiaeia iaoaiaoe/iiai aiaeico ia IAII c
canoinoaaiiyi iaeaoo i?eeeaaeieo noaoenoe/ieo i?ia?ai “Statgraf”.

?ACOEUeOAOE AeINEIAeAEAIUe OA IO IAAIAI?AIIss

Aiiaia?aaoe/iee aiiainoac aeineiaeaeaii o 299 oai?eo ia OIIE o aioei
aiae 39 aei 79 ?ieia. ?c ieo ii/aoeiaa noaaeiy AeA aeyaeaia o 117
oai?eo, na?aaeiie aie yeeo neeaa 45 ?ieia, II noaaeiy – o 113 iaoei?ioia
(na?aaeiie aie – 57 ?ieia), III – o 69 inia (na?aaeiie aie – 64 ?iee).
A?oio ii?iaiyiiy neeaee 39 caei?iaeo inia aiaeiiaiaeiiai aieo. Na?aae
eeiii/ieo neiae?iiia o oai?eo anio noaaeie iae/anoioa cono?i/aeeny
iaa?iciiiaeiaiee oa neiae?ii aaaaoaoeaii? aeenooieoei?. A i?ioeani
i?ia?anoaaiiy caoai?thaaiiy eieueeinii oa yeinii c?inoaee aeenniiii/ii
(a I noaaei? – o 49,6%; a II – o 77,8%; a III noaaei? – o 97%
aeiaaeeia), aanoeaoey?ii-aoaeoe/ii (o 67,5%; 84,9%; 81% aeiaaeeia
aiaeiiaiaeii), ii?aiiaeii (o 58,1%; 71,6%; 71% aeiaaeeia, i?e/iio o II
noaaei? c ieo o 42% iaoei?ioia, a a III noaaei? o 60,6% – ia?ace),
iioaeaeooaeueii-iianoe/ii ii?ooaiiy (o 72,6%; 73,4% oa 82,6% aeiaaeeia
aiaeiiaiaeii), i?e/iio a III noaaei? eiaiioeaii ii?ooaiiy o 30%
aeinyaaee ?iaiy aeaiaioei?. A AeA III noaaei? o 17,4% oai?eo c’yaeyany
aiiinoaoe/iee neiae?ii, o 10% – inaaaeiaoeueaa?iee, o 18,8% –
aeno?aii?aiiaeiee. O 4 oai?eo aeiaaiinoiaaia oai?iaa Aiinaaiaa?a.

?acoeueoaoe aea/aiiy oea?aa?aeueii? aaiiaeeiaiiee ca aeiiiiiaith ?OeAA
iieacaee, ui c i?ia?anoaaiiyi OIIE iiaeaeuoaaany caaaeueiee /an
iiceiaiai e?iaiiaiao a 1,64 ?aca a ii?iaiyiii c eiio?ieueiith a?oiith,
i?e/iio a I coaaei? iiaeiaaeaiiy aiaeaoaaeiny ia?aaaaeii ca ?aooiie
eaiiey?ii? oa aaiicii? oac, a a III noaaei? – aianeiaeie ii?ooaiiy
oeaio?aeueii? aaiiaeeiaiiee (aiiieiiaoe/iee oei e?iaiiaiao, iiaeaeuaiiy
caaaeueiiai ia?eoa?e/iiai noaeeiiiai iii?o (CINI)). Ia OEAe oei i?ioeane
ciaoiaeeee aiaeia?aaeaiiy a cieaeaiii na?aaeiuei? oaeaeeinoi e?iaiiaiao
a 1,8 ?aca a ea?ioeaeiiio oa a 2 ?ace a aa?oaa?iaaciey?iiio aanaeiao, a
oaeiae o iiaeaeuaiii iiaeaeno iii?o i cieaeaiii iiaeaeno ?aaeoeaiinoi
oea?aa?aeueieo noaeei.

Oea?aa?aeueia iae?iaeeiaiiea oa?aeoa?ecoaaeany cieaeaiiyi aiieiooaee i
iiooaeiinoi niaeo?ia aeueoa-, aaoa-?eoiia oa c?inoaiiyi aiieiooaee i
iiooaeiinoi niaeo?ia oaoa- i aeaeueoa-?eoiia c iiyaith eiaoioei?ioia
iiaeiiaeoeaai? aneiao?i?. C i?ia?anoaaiiyi OIIE caeaaeaeoaaeany
?aaiiia?ia aiaeiiiiinoue ?eoiia oa cieaeoaaeany ?aaeoeaiinoue ia
ooieoeiiiaeueii i?iae.

Iae?iaicoaeicaoeiy no?oeoo? aieiaiiai iiceo oai?eo ia AeA aeyaeea
iai?yii iciaee eiai ao?ioi? o aeaeyaei aioo?ioiuei? oa ciaiioiuei?
aiae?ioeaoaei?, ae?aaeaiinoue yeeo c?inoaea c i?ia?anoaaiiyi OIIE. Oae,
oe?eia ia?aaeiueiai ?iao aieiaiai oeoii/ea ceiaa c?inoaea a o?ao?e
noaae?? 1,9 ?aca, ni?aaa – a 1,6 ?aca; oeaio?aeueiiai aiaeaeieo eiaiai
oeoii/ea – a 1,8 ?aca, i?aaiai – a 1,6 ?aca, ui naiae/eei i?i
oaiaeaioeith aei aieueoiai ?icoe?aiiy oeoii/eia ceiaa. Oe?eia o?aoueiai
oeoii/ea c?inea c 5,0 0,86 ii a ia?oie noaaei? aei 7,0 0,84 a o?aoie
(p<0,01). A II oa III noaaeiyo OIIE aeyaeaii iaeeie/ii ina?aaeee i?aeoeueii? eieae?caoe?? (o 25%) oa /eneaiii ae?iaiiina?aaeeiai (o 26% aeiaaeeia) iioa?eoe c eieaeicaoei?th a aeeaieeo aiaeaeieao iiceo (eaeoia?ii) aai iiaa?oiaai, ui oi?ioaaee a?aioey?io ao?ioith ei?e aaeeeeo iiaeoeue (o 3 oai?eo). O 8 iaoei?ioia ia I?O aeyaeyeenue yaeua eaeeia?aico ??ciiai nooiaiy ae?aaeaiino?. Aiiaia?aaoe/iee aiiainoac oai?eo ia o?iii/io iiceiao aeenoee?eoeyoeith i?iaiaeiciaaii ianaiia?aae o caeaaeiinoi aiae ?? aoeieiai? oa eeiii/ii? noaaei? AeA. ?acoeueoaoe aeineiaeaeaiue naiae/aoue, ui ia anio aoaiao oi?ioaaiiy OIIE ?icaeaaany aia?aaoe/iee aeaoioeeo, yeee c?inoaa c i?ia?anoaaiiyi aaiiaeeiaii/ieo ?iceaaeia i caeaaeaa ia noieueee aiae ?o aaiaco (aeinoiai?ii? ?icieoei iiae ae?aaeaiinoth aia?aiaeaoioeeoo i?e aoa?ineea?ici noaeei aieiaiiai iiceo i AO ia aeyaeaii, ?>0,05), neieueee
aiae nooiaiy ii?ooaiue aaiiaeeiaiiee. Oae, aiino AOO i?e AeA ? no.
cieaeoaaany eeoa ia 3%, i?e AeA ?? no. aaea ia 28%, a a ??? no. – ia 48%
i?e iinoieiiio c?inoaiii iiaeaeno AAeO/AOO, ui naiae/eei i?i ia?inoaiiy
aeenaaeaino iaiiio iae?ia?ai/ieo niieoe c iineeaiiyi oea?aa?aeueii?
ioaii? (oaae.1). Ca’ycie aia?aaoe/iiai aeaoioeeoo c iiaeeaeaiiyi
aaiiaeeiaii/ieo ii?ooaiue iiaeoaa?aeaeoaaany e?i?eieie ?aa?anieieie
caeaaeiinoyie iiae aiinoii AOO i na?aaeiueith oaeaeeinoth iiceiaiai
e?iaioieo ca aeaieie OEAe, a oaeiae caaaeueiei /anii oea?aa?aeueiiai
e?iaioieo ca aeaieie ?OeAA:

Y = 151,4 7,9 X1

Y = 925,2 25 X2 ;

aea – Y – ?iaaiue AOO, O1 – na?aaeiy oaeaeeinoue e?iaioieo
ca aeaieie OEAe; O2 – caaaeueiee /an iiceiaiai e?iaioieo.

Io?eiaii noaoenoe/ii caeaaeiinoi naiae/eee i?i iiceoeaiee eiiieiee
?aa?an?eiee ca’ycie iiae aiinoii AOO i na?aaeiueith oaeaeeinoth
e?iaiiaiao oa iaaaoeaiee eiiieiee ca’ycie c caaaeueiei /anii iiceiaiai
e?iaioieo. I?e/iio iaeieae/ee aiino AOO niinoa?iaaany i?e iiaeiaaeaiii
eaiiey?ii? oace e?iaioieo, i?i ui naiae/ea iaeaeuee eiaoioei?io
ei?aeyoei? ?iaiy AOO oa o?eaaeinoi aeacaii? oace (r = -0,45) a
ii?iaiyiii c eiaoioei?ioaie (r = -0,36; -0,34; -0,33), yei iia’ycothoue
?iaaiue AOO i aiaeiiaiaeii o?eaaeinoue oace I, oace 1,oace 3, oiaoi
i?eoieo e?iai ii iaaino?aeueieo a?oa?iyo, iio?ae?aiiaeueieo a?oa?iyo oa
aiaeoieo ii aaiao (p<0,05). Oaaeeoey 1. Noai aiiaia?aaoe/ieo i?ioeania o oai?eo ia OIIEa caeaaeiinoi aiae eeiii/ii? noaaei? AeA IieacieeenEiio?ieuen = 39AeA 1 no.n = 117AeA 2 no.n = 113AeA 3 no.n = 69AOO ieiieue/e625 + 15612 + 14456 + 20*329 + 22*AAeO/AOO0,177 0,0050,193 0,009*0,274 0,021*0,326 0,034*EAeA ieiieue/e 2,12 0,112,75 0,06**3,58 0,08*3,06 0,06*EAeA1+2 %77,361**57,2*47*EAeA4+5 % 6,312,4*17*22,5*OOE, ieiieue/a. a.aiae.7,0 0,518,4 2,1*25,8 4,5*12,3 1,9**AE, ieiieue/a. a.aiae.6,6 0,117,8 1,6*23,4 5,9*11,3 2,5**AAe, ieiieue/a. a.aiae.0,75 0,032,53 0,46*4,11 0,9*1,56 0,26**A-6-OAeA, ieiieIAAeO.I + iei a?eo?. ca 1oa.1,11 0,041,77 0,18**2,03 0,11*1,63 0,12*** - ?<0,001; ** - p< 0,01; *** - p<0,05 a ii?iaiyiii c eiio?ieai Iaeii/anii o oai?eo ia OIIE iiaeaeuoaaany ?iaaiue aeieieioe/ieo oa?iaioia, ianaiia?aae eeth/iaiai oa?iaioo aeieieico – EAeA. I?e/iio iineeaiiy aeoeaiinoi EAeA aiaecia/aeiny ia?o ca ana ca ?aooiie c?ooaiue ?? icioa?iaioiiai niaeo?o a aie caieueoaiiy "aiaa?iaieo" (eaoiaeieo) o?aeoeie EAeA4+5 i?e ciaioaiii ?iaiy "aa?iaieo"(aiiaeieo) EAeA1+2. I?e/iio o oai?eo c ae?aaeaiith iiceiaith aeenoee?eoeyoei?th caaaeueiee aiino EAeA cieaeoaaany, ui iiaei naiae/eoe i?i cieaeaiiy ?iaiy aia?aaoe/iiai iaoaaieicio ye a aa?iaiiio, oae i a aiaa?iaiiio oeeeeao (aeea. oaae.1) Aeeiaiiea aeoeaiinoi iioeo oa?iaioia aeieieico (OOE, AE, AAe) a oeieiio iiaoi?thaaea oaiaeaioei? EAeA. Oae, o ii/aoeiaie noaaei? AeA ?a?no?oaaeiny iaeiiiai?aaeaia iiaeaeuaiiy ?o ?iaiy, ui iiaeoaa?aeaeoaaei aeoeaaoeith i?ioeania aiaa?iaiiai aeieieico a oiiaao ioaii? i aiiieni?. C i?ia?anoaaiiyi aeenoee?eoeyoei? aeoeaiinoue aeieieioe/ieo oa?iaioia o oeieiio iiaeaeuoaaeany, a a o?aoie noaaei? OIIE aeyaeyeiny iaeiiiai?aaeaia cieaeaiiy ?o ?iaiy (aeea. oaae.1). Oi/a i?e aieueo aeieeaaeiiio aiaeici noaio i?ioeania aeieieico aeyaeeeny iaiaeiicia/ii oaiaeaioei? ?iaiy aeieieioe/ieo oa?iaioia o oai?eo ia AeA II no.: o 76% iaoei?ioia ?o aeoeaiinoue c?inoaea, a o 24% – cieaeoaaeanue ii aiaeiioaiith aei iiia?aaeiuei? noaaei?, oi/a cieaeaiiy i ia iaaoaaei aeinoiai?ieo cia/aiue (p>0,05). O ii/aoeiaie noaaei? OIIE aiaeaoaaeany
oaeiae aeoeaaoeiy, a c i?ia?anoaaiiyi aeenoee?eoeyoei? cieaeaiiy
aeoeaiinoi iaioiciiai oeeeeo ia?aoai?aiiy aoaeaaiaeia, ui ciaeoei
aiaeia?aaeaiiy o aiaeiiaiaeiie aeeiaiioei aetheici-6-oinoaoAeA (aeea.
oaae. 1).

O oai?eo c ?icaeoeii OIIE aeyaeaia c?inoaiiy aiinoo eaeoaoo oa ii?oaaoo
a ne?iaaooei e?iai. A ? no. AeA ?o ?iaaiue iiaeaeuoaaany ia 47,8% i
71,2%; a ?? no. – ia 65,5% i 84,1% aiaeiiaiaeii, a a ??? no. aiino
eaeoaoo ciaiooaaany ia 24,3%, a ii?oaaoo ia 23% ii aiaeiioaiith aei
iiia?aaeiuei? noaaei?. Eiaoioei?io ii?oaao/eaeoao iiaeaeuoaaany
aiaeiiaiaeii a eiaeiie ianooiiie noaaei? a 1,16; a 1,28; a 1,31 ?ace, ui
oaeiae naiae/eei i?i iiaeeaeaiiy aeieoaaiiy aa?iaieo oeeeeia ieeneaiiy
aetheice. Aiino aetheice a e?iai ia ii/aoeiaeo noaaeiyo o?iii/ii?
iiceiai? aeenoee?eoeyoei? aeinoiai?ii ia ciiithaaany, eeoa a o?aoie
noaaei? OIIE niinoa?iaaeanue oaiaeaioeiy aei aiia?aeieaii?.

Oaeei /eiii, i?iaiaeiei i?iyaii aiiaia?aaoe/iiai aeenaaeaino ia anio
aoaiao OIIE ? aia?aaoe/iee aeaoioeeo, yeee ?icaeaa?oueny aianeiaeie
i?eaii/aiiy i?ioeania ieenethaaeueiiai oinoi?eethaaiiy. A ii/aoeiaie
noaaei? aeenoee?eoeyoei?, ye eiiiainaoi?ia ?aaeoeiy o aiaeiiaiaeue ia
cieaeaiiy aa?iaiiai aeieieico, aeoeaico?oueny iaioicioinoaoiee oeyo
ia?aoai?aiiy aetheice oa aiaa?iaiee aeieieic, ui aaaaea?oueny oeiiaei
iaoieiai/iei i?ioeanii i?e aiiieni? (A.I.E?eaeaiianueeee, 1997).
Aeoeaaoeiy aiaa?iaiiai aeieieico c iaeiiai aieo ? aaeaioaoeieiei
iaoaiiciii aei aiiieni?, c ae?oaiai aieo i?eaiaeeoue aei iaeiie/aiiy
eaeoaoo i ?icaeoeo eaeoaoeeaeico E??i oiai, i?aeaeuaiiy ??aiy eaeoaoo oa
i??oaaoo noeioeth? neioac oieanoa?eio oa aee?ieo eeneio (R.A.Harris,
1985; V.Bartley, 1986). Oea iiaea iani?eyoeeai iicia/eoeny ia ia?aa?ao
aoa?ineea?ico noaeei aieiaiiai iiceo, i?i ui na?ae/eoue a?eyaeaiee
iiceoeaiee ei?aeyoe?eiee ca’ycie i?ae ??aiai eaeoaoo ? oieanoa?eiii (r =
+0,56, p < 0,05) oa eaeoaoii ? eiao?oe??ioii aoa?iaaiiino? (r = +0,48, ? < 0,05). Cieaeaiiy aeieieioe/ieo i?ioeania o /anoeie oai?eo II oa o anio oai?eo III noaaeie OIIE naiae/eei i?i c?ea eiiiainaoi?ieo ?aaeoeie oa caaaeueia i?eaii/aiiy aia?aaoe/iiai iaoaaieicio. I?e /iio aacaaeaioeai? ci?ie ii/eiaeeny aaea a ?? no. AeA ? iiaeeaethaaee aia?aaoe/iee aeao?oeeo. Aia?aaoe/iee aeaoioeeo o iaeaieueoie ii?i aoa iia’ycaiee c ii?ooaiiyi aaiiaeeiaiiee a iie?ioee?eoeyoi?iiio ?onei. Aeeaeia ii?ooaiue aia?aaoe/iiai iaoaaieicio caeaaeaea oaeiae aiae ae?aaeaiinoi no?oeoo?ieo ciii aieiaiiai iiceo. Ia iniiai ?acoeueoaoia iae?iaicoaeicaoeieieo aeineiaeaeaiue na?aae oai?eo ia OIIE aeaeieaii /ioe?e a?oie c ?icieie aa?iaioaie no?oeoo?ieo ii?ooaiue, a caeaaeiinoi aiae yeeo i i?iaiaeiciaaii aiiaia?aaoe/ii iieacieee. O ? a?oii (31 oai?ee) aac no?oeoo?ieo ciii ia EO i I?O, aea c yaeuaie aiae?ioeaoaei?, ?iaaiue AOO neeaa 565 34 ieiieue/e (eiio?ieue 625 15 ieiieue/e). A ?? a?oii, o yeo aaieoee 25 oai?eo c iaeeie/ieie ae?iaiiina?aaeeiaeie iioa?eoaie, aiino AOO noaiiaea 483 38 ieiieue/e. O oai?eo ??? a?oie (26 iaoei?ioia) c aeeoocieie ae?iaiiina?aaeeiaeie ciiiaie oa yaeuaie eaeeia?aico ?iaaiue AOO neeaa 330 35 ieiieue/e. O ?V a?oii c e?oiiiina?aaeeiaeie iioa?eoaie (15 oai?eo) aia?aicaaacia/aiinoue noaiiaeea 392 40 ieiieue/e. sse naiae/aoue iaea?aeaii aeaii, ia?inoaiiy no?oeoo?ieo ciii aieiaiiai iiceo i?e OIIE iiaeeaeth? aia?aaoe/iee aeaoioeeo. I?e/iio iaeaieueoa i?eaii/aiiy aia?aaoe/iiai iaoaaieicio (aa?iaiiai oa aiaa?iaiiai eiai oeeeeia) niinoa?iaaeiny o oai?eo c aeeoociith iaoieiai?th aieiaiiai iiceo. Aiiieniy oa aia?aaoe/iee aeaoioeeo ciaoiaeeee aiaeia?aaeaiiy ia AAA. I?e niianoaaeaiii niaeo?ia iiooaeiinoae iniiaieo ?eoiia AAA c aiiaia?aaoe/ieie iieacieeaie aeyaeaii ai?iaiaeii (p<0,05) ei?aeyoeieii caeaaeiinoi aeey iieacieeia iiooaeiinoi -, -, -, -?eoiia oa ?iaiia eaeoaoo i AOO. Aeyaeeinue, ui iiaieueii-oaeeueiaa aeoeaiinoue aieueo /ioei iia’ycaia c ia?inoaiiyi aiiieni? (eiaoioei?ioe ei?aeyoei? iiooaeiinoae oaoa- i aeaeueoa-?eoiia c ?iaiai eaeoaoo noaiiaeee r = +0,51; +0,63), a aeniei/anoioii ?eoie aieueo iia’ycaii c ?iaiai aia?aicaaacia/aiiy (eiaoioei?ioe ei?aeyoei? aeueoa- i aaoa-?eoiia c ?iaiai AOO noaiiaeee r = +0,58; +0,52). Aiaeic aiiaia?aaoe/ieo iieacieeia o caeaaeiinoi aiae oa?aeoa?o AAA-ciii iieacaa, ui iaecia/iioee aia?aiaeaoioeeo (aiino AOO 354 28 ieiieue/e) aeyaeany i?e aeainoi?iiiueiio ia?ieneciaeueiiio oeiiai ciii oa aiieaioeoi?iiiio oeiiai (318 14 ieiieue/e). Oiiaii ii?iaeueiee oei AAA, yeee niinoa?iaaany o 27% oai?eo ia AeA I noaaei? oa 8,3% ia AeA II noaaei?, ii aia?aicaaacia/aiith ai?iaiaeii ia aiae?iciyany aiae ii?ie (612 10 ieiieue/e, i?e eiio?iei 625 15 ieiieue/e). C oeei, i/aaeaeii, iia’ycaia aiaeiinii ii?iaeueia ?iciiaeieaiiy ?eoiia AAA o aeaii? a?oie oai?eo, aea cieaeaia ?? ?aaeoeaiinoue ia iaaaioaaeaiiy. A?aoiaoth/e aaaeeeao ?ieue iaia?aiii? iaoieiai? a ?icaeoeo ii?ooaiue aia?aaoe/iiai iaoaaieicio, iaie aoei i?iaiaeiciaaii noai ieneaeaioii-aioeieneaeaioieo nenoai, o?aeoe?eia ni?aaeiioaiiy oinoie?i?ae?a iaia?ai oa ??aaiue ia?ea?ieo iaia?aiica’ycaieo oa?iaio?a o caeaaeiinoi aiae nooiaiy aeenoee?eoeyoei?. sse naiae/aoue ?acoeueoaoe aeineiaeaeaiiy, ia ii/aoeiaie noaaei? aeenoee?eoeyoei? aiaeaoaaeany aeoeaaoeiy ye IIE, oae i nenoaie aioeieneaeaioiiai caoenoo, ui, ia iao iiaeyae, iaei eiiiainaoi?ia cia/aiiy (neiae aiaecia/eoe, ui ca iaoiaeeeith ia?ieneaeacia aeoeaiinoue iia’ycaia c aiinoii ia?ieneaeace cai?ioiuei-i?iii?oeieii). C i?ia?anoaaiiyi aeenoee?eoeyoei? nenoaia aioeieneaeaioiiai caoenoo cieaeoaaeany, ui ni?aiaaeaei c ?inoii aiinoo i?iaeoeoia IIE. Ia o?aoie noaaei? OIIE ?a?no?oaaeiny ciaioaiiy aeoeaiino? i?ioean?a IIE, ui ii?aeioaaeiny ci cieaeaiiyi oeeeeia aia?aiooai?aiiy a oeieiio (oaae. 2). Oaaeeoey 2 Noai ieneaeaioii-aioeieneaeaioii? nenoaie o oai?eo OIIE ?icieo noaaeie IieacieeeEiio?ieuen = 35I noaaeiyn = 96II noaaeiyn = 83III noaaeiyn = 46AeE, ieiieue/e156,55,3166,55,6190,47,8*177,46,9**IAeA, ieiieue/e11,21,011,91,116,82,3*17,02,0*SH-a?oie, iiieue/e10,51,213,01,2*8,01,3*7,30,9*Aeooaoiii, iiieue/e0,520,010,610,03*0,500,060,460,09*Eaoaeaca, ieao/Hb3,050,113,020,113,060,122,930,16Ia?ieneaeaca, ieao/Hb5,920,614,910,327,820,21*7,890,26* * – p<0,001 o ii?iaiyiii c eiio?ieai ** – p<0,01 o ii?iaiyiii c eiio?ieai Niianoaaeyth/e io?eiaii ?acoeueoaoe aiinoo i?iaeoeoia IIE oa aioeieneaeaioiiai caoenoo c ?iaiai aaeaiieiaeo ioeeaioeaeia, eieueeinoue yeeo aeinoiai?ii ii/eia? cieaeoaaoeny naia a II noaaei? OIIE, iiaeia aiai?eoe i?i iiaiaoth/ee aieea IIE ia aeoeaiinoue oa?iaioia oeeeeo E?aana. Oea iiaeoaa?aeaeoaaeiny iayaiinoth noaoenoe/ii aeinoia??ii? iaaaoeaii? ei?aeyoeieii? caeaaeiinoi iiae aiinoii AOO i IAeA (r = -0,51) oa AOO i AeE (r = -0,48). A ?acoeueoaoi aeoeaaoei? IIE iineethaaeany i iaia?aiia iaoieiaiy, yea aeyaey?oueny a ciiii ie?aieo o?aeoeie oinoieiiiaeia (OO) a?eo?ioeeoa?ieo iaia?ai. Ia ii/aoeo ?icaeoeo o?iii/ii? aeenoee?eoeyoei?, eiee ua neeueiee aioeieneaeaioiee caoeno, c?ooaiiy iiae ie?aieie o?aeoeiyie OE ia ai?iaiaeii. A i?ioeani ae iiaeeaeaiiy OIIE aeieea? iiaeaeuaiiy eiioeaio?aoei? oinoaoeaeeeoieiio (OO) ia 7% a II noaaei? oa ia 21,5% a III noaaei? AeA, eicioinoaaeeoeeaoaiieaiiio (EOAE) ia 42,8% oa 85,7% aiaeiiaiaeii, eicioinoaoeaeeeoieiio (EOO) ia 46,6% i 93,3% aiaeiiaiaeii a niieo/aiii ci cieaeaiiyi oinoaoeaeeeaoaiieaiiio (OAA) ia 17,9% ai II noaaei? i 35,7% a III noaaei? AeA, a noiiaiii?eeio (NI) ia 12,9% i 16% aiaeiiaiaeii (oaae. 3). Oaaeeoey 3. Aiino oinoieiiiaeieo o?aeoeie iaia?ai a?eo?ioeeoia o oai?eo ia OIIE a %. O?aeoei? OEEiio?ieueia a?oia (n=30)AeA I no. (n=36)AeA II no. (n=42)AeA III no. (n=31)OO39,6 + 2,739,9 + 2,542,4 + 1,6*48,1 + 1,8**EOAE1,4 + 0,31,52 + 0,212,0 + 0,11*2,6 + 0,31**EOO1,5 + 0,31,58 + 0,262,2 + 0,312,9 + 0,29EE0,5 + 0,10,51 + 0,110,59 + 0,210,60 + 0,18OAA24,6 + 2,324,0 + 2,120,2 + 1,6*16,3 + 0,92**NI16,2 + 0,915,9 + 0,814,1 + 0,2*13,6 + 0,3**ON8,9 + 1,18,85 + 1,18,81 + 0,98,81 + 0,15OI7,7 + 0,567,6 + 0,486,0 + 0,6*4,8 + 0,2*** – ?<0,01; ** – ?<0,001 a ii??aiyii? c eiio?ieai. I?iaaaeaiee ei?aeyoeieiee aiaeic iiae iieacieeaie IIE, aioeieneaeaioiiai caoenoo oa o?aeoeiyie oinoieiiiaeia aoei aeyaeaii, ui cieaeaiiy aioeieneaeaioiiai caoenoo (?iaaiue aeooaoiiio) noi?iaiaeaeo?oueny iiaeaeuaiiyi eiioeaio?aoeie OO, EOAA, EOO (r = -0,30; -0,50; -0,38 aiaeiiaiaeii, p<0,01) oa ciaioaiiyi o?aeoeie OAA, NI, ui eaaei ieeneththoueny (r = +0,35; +0,28 aiaeiiaiaeii, p<0,01). Iaeiie/aiiy AeE niiaiaaeaei c ?inoii OO, EOAA, EOO (r = +0,29; +0,54; +0,36 aiaeiiaiaeii, p<0,05) oa cieaeaiiyi OAA i NI (r = -0,43; -0,30, p<0,05). ?icaeoie iaia?aiii? iaoieia?? ia ii/aoeia?e noaae?? AeA, a iio?i iiaeaeueoa ?? i?ia?anoaaiiy i?aeoaa?aeaeo?oueny oaeiae i?aeaeuaiiyi aeoeaiino? ia?ea?ieo iaia?aiica’ycaieo oa?iaio?a. I?e/iio, yeui ia ii/aoeia?e noaae?? AeA i?aeaeuaiiy iineoue oa?aeoa? oaiaeaioe?? (?>0,05), oi a ae?oa?e noaae?? iaeaoaeaa?ae?iaaiaca ? e?aaoeioinoie?iaca
i?aeaeuothoueny a 1,3 ?aca, ania?aa?iiaa o?ainai?iaca – a 2 ?ace,
aeai?iiaa o?ainai?iaca – a 2,2 ?aca, -aeooaiao-o?ainoa?aca – a 1,6 ?aca,
-a?ae?ieneaooe?aoaeaa?ae?iaaiaca – a 1,4 ?aca, eoaeia oinoaoaca – a 2,1
?aca (?<0,001). Ciiia o?aeoeieiiai niiaaiaeiioaiiy oinoie?i?ae?a o iaia?aiao iiaea iineethaaoe ii?ooaiiy ca’yceo oeaieiiiai aeeoaiiy oa ieenethaaeueiiai oinoi?eethaaiiy, ui oaeiae iiaeeaeth? aia?aaoe/iee aeaoioeeo. I?e aiaeici aiiaia?aaoe/ieo oa iae?iaoii?aeueieo iieacieeia o oai?eo ia OIIE a caeaaeiinoi aiae ia?aaaaeaiiy ?icieo eeiii/ieo neiae?iiia anoaiiaeaii, ui iaecia/iioee aia?aaoe/iee aeaoioeeo (cieaeaiiy ?iaiy AOO ia 46% o ii?iaiyiii c eiio?ieai, p<0,001) ?a?no?o?oueny o oai?eo c aeaiaioei?th, ui niiaiaaea? c aenia?eiaioaeueieie aeaieie uiaei cieaeaiiy aia?aiooai?thth/eo i?ioeania o oeeeei E?aana a ei?i aaeeeeo iiaeoeue. Aia?aaoe/iee aeaoioeeo ii?aeioaaany ci cieaeaiiyi aiinoo aiiaaiieo iiiiaiiiia (iniaeeai ?o iiia?aaeieeia ia 18% (p<0,05), iiaeaeuaiiyi aiinoo Na a a?eo?ioeeoao ia 11,1% (p<0,001), iineeaiiyi aeoeaiinoi IAI ia 29,5% (p<0,05) oa cnoaii niiaaiaeiioaiiy iae?iiaaeiaoi?ieo aiiiieeneio o aie caoaeeeaeo, ui a aenia?eiaioi niieo/aeiny ci ciaioaiiyi aeoeaiinoi aeooaiao-AeA ia 47% (?<0,02). I?e aeaiaioei? niinoa?iaaany oaeiae i iaeieae/ee aioeieneaeaioiee caoeno. Oiaoi aeaiaioeiy ia oei OIIE aeyaeeany oei neiae?iiii, i?e yeiio iaoieiai/ii oaeoi?e (aeooaiao, Na2+, aia?aiaeaoioeeo, iaia?aiia iaoieiaiy) i?iyaeeeny a iaeaieueo ni?eyoeeaiio niieo/aiii aeey caioneo iaoaiiciia caaeaaei iae?iiia (A.I.E?eaeaiianueeee, 1997; R.S.Howard, 1994; P.Iener, 1994; K.Bhagat, 1996). Na?aae ?icieo aa?iaioia iaa?iciiiaeiaieo ii?ooaiue iaeieae/a aia?aicaaacia/aiinoue oa?aeoa?ia aeey oai?eo c anoaii/iei (cieaeaiiy AOO ia 18% aiaeiinii eiio?ieth, p<0,01) oa aeai?aneaiei (?iaaiue AOO ieae/ee ia 20% aiaeiinii eiio?ieth, p<0,01) neiae?iiaie a ii?iaiyiii c o?eaiaeii-oiai/iei (cieaeaiiy aiinoo AOO ia 9,8%, p<0,05). Oiaoi iaaioue iacia/ia cieaeaiiy aia?aicaaacia/aiiy, ciiithth/e iioaa?aoeaio aeiyeueiinoue aieiaiiai iiceo, ni?ey? ?icaeoeo iaa?iciiiaeiaieo ii?ooaiue. ?acoeueoaoe ?icieo aa?iaioia oa?aii?, ni?yiiaaii? ia ii?iaeicaoeith aaiiaeeiaiiee oa i?ioeania aia?aiooai?aiiy, iniaeeai o oai?eo ia OIIE ii/aoeiai? noaaei?, iiaeoaa?aeeee aca?iicaeaaeiinoue aaiiaeeiaii/ieo oa aiiaia?aaoe/ieo ii?ooaiue. Oae, eieoaaiiy a?oie 52 /ieiaieia aieii aiae 45 aei 53 ?ieia (? a?oia) aaciaeoeaieie i?aia?aoaie i?eaaei aei iiceoeaii? aeeiaiiee aiiaia?aaoe/ieo i?ioeania. I iaaiaee, eieoaaiiy a?oie 57 /ieiaieia c iaeaioe/ieie eeiii/ieie i?iyaaie AeA I noaaei? aieii aiae 44 aei 55 ?ieia (?? a?oia) aeoeaaoi?aie ieenethaaeueiiai oinoi?eethaaiiy i oeaieiiiai aeeoaiiy a caaaeueii i?eeiyoeo aeicao i?eaaei aei iiceoeaieo ciii i aia?aaoe/iiai iaoaaieicio, i oea?aa?aeueii? aaiiaeeiaiiee (?en. 1). Ii?iaiyiiy aoaeoeaiinoi eieoaaiiy a?oie oai?eo ia OIIE II noaaei? (49 iaoei?ioia) c aeei?enoaiiyi caaaeueiii?eeiyoi? noaeeiii? oa?aii? oa a?oie oai?eo (56 iaoei?ioia) c iaeaioe/ieie eeiii/ieie oa aaiiaeeiaii/ieie i?iyaaie c aeei?enoaiiyi aacenii? oa?aii? a niieo/aiii c aeoeaaoi?aie aiiaia?aaoeee iieaca- ei, ui aoaeoeaiinoue oa?aii? o oai?eo ae?oai? a?oie aeua ye ca noa’?eoeaieo, oae i ca ia’?eoeaieie iieacieeaie. ?acii c oei caa?ioa ia naaa oaaao oie oaeo, ui o 17% oai?eo ia oei ii?iaeicaoei? aaiiaeeiaii/ieo iieacieeia ia aiaecia/aeiny iie?auaiiy eeiii/ii? neiioiiaoeee, a o 6% – iaaioue ?? iineeaiiy. Aiaeicoth/e i?e/eie aeennioeiaoei? iiae iie?auaiiyi oea?aa?aeueii? aaiiaeeiaiiee oa iiaeeaeaiiyi iaa?ieiai/ieo i?iyaia caoai?thaaiiy, aoei aeyaeaii, ui o oei?? a?oie oai?eo aiaeaoeany aeoeaaoeiy IIE c iiaeaeuaiiyi IAeA i AeE ia 48% i 21% aiaeiiaiaeii. Oiaoi aeoeaaoi?e iaoaaieicio, iie?auoth/e oea?aa?aeueio aaiiaeeiaiieo a oiiaao cieaeaiiai aioeieneaeaioiiai caoenoo o oai?eo ia OIIE II i III noaaei?, iiaeooue coiiaethaaoe iineeaiiy aieueii?aaeeeaeueieo i?ioeania. Oiio aeoeaia iaoaaiei/ia oa?aiiy iiaeiia i?iaiaeeoeny oieueee a niieo/aiii c i?aia?aoaie aioeieneaeaioii? ae??. A?aoiaoth/e iayaiinoue o iecueeiiioaineaiiai eaca?iiai ii?iiiithaaiiy aioeieneaeaioii? (N.I.Coaeiaa, 1997; A.N.Aiiaea?aiei, 1997; A.N.Ai?a c? ni?aaao., 1997) oa aeoeaii? iaoaaiei/ii? aei? (I.C.Iaioeia, 1997) a eiiieaeniiio eieoaaii? a?oie oai?eo ia OIIE ? no. ie canoinoaaee iaoiae eaca?ioa?aii?. Aoei aeiaaaeaii, ui iaee?auee oa?aiaaoe/iee aoaeo niinoa?iaaany i?e niieo/aiiio aieeai ia ?aoeaeniaaiii ciie eii??oeaai? iaeanoi ca aeiiiiiaith AEO “Ionoaia” c aeiaaeeiith oaeei 0,89 iei oa iiooaeiinoth iiioeueno 3000 Aoe c iaaeaaiiei ii?iiiithaaiiyi eieoueiai? aaie He-Ne- eaca?iei i?iiaiai c aeiaaeeiith oaee? 0,63 iei oa aeniiceoe??th 10-15 oaeeei. ?acoeueoaoe aenia?eiaioaeueieo aeineiaeaeaiue iiaeoaa?aeeee iayaiinoue aia?aaoe/iiai aeaoioeeoo i?e oea?aa?aeueiie ioaii? ca ?aooiie cieaeaiiy i?ioeania ieenethaaeueiiai oinoi?eethaaiiy. Oae, o aeineiaeaeoaaieo iaeanoyo aieiaiiai iiceo aenia?eiaioaeueieo oaa?ei cieaeoaaeany aeoeaiinoue iioioiiae?iaeueieo oa?iaioia (eeth/iaeo oa?iaioia oeeeeo o?eea?aiiiaeo eeneio, a oaeiae iiceiaiai icioa?iaioo aethoaiaoaeaaiae?iaaiace (AAeA). Oae, aeoeaiinoue noeoeeiao-AeA a ei?i aaeeeeo iiaeoeue ciaiooaaeany a 2 ?ace, a aiiioaeaioni – a 1,5 ?aca. Oaea ae caeiiiii?iinoue niinoa?iaaeany aeey aeoeaiinoi oeeo?aoneioace. Cia/ii iaioa cieaeoaaeany aeoeaiinoue aeueoa-eaoiaeooa?ao-AeA. ?iaaiue AAeA cieaeoaaany a ei?i a 1,6 ?aca, a aiiioaeaioni a 1,2 ?aca. Oaeei /eiii, iaeaieueo nooo?ai ciiie aeyaeyeeny a ei?i aaeeeeo iiaeoeue (oaae.4). Iaeii/anii aeoeaiinoue aeieieioe/ieo oa?iaioia o oeo aea iaeanoyo aieiaiiai iiceo iiaeaeuoaaeany. Oae, aeoeaiinoue AAe a ei?i aaeeeeo iiaeoeue c?inoaea a 2 ?ace, a aiiioaeaioni – a 1,6 ?aca, a noiaao?i iiceo – a 1,3 ?aca; aiino OOE a ei?i aaeeeeo iiaeoeue caieueooaaany a 2,8 ?aca, a aiiioaeaioni i noiaao?i aieiaiiai iiceo – a 2 ?ace a ii?iaiyiii c eiio?ieai Oaaeeoey 4. Aeoeaiinoue iioioiiae?iaeueieo oa?iaioia o aieiaiiio iiceiai aenia?eiaioaeueieo oaa?ei o ii?ii i i?e aoa?ineea?ici (A) Iaeano? iiceoNoeoeeiao-AeA iiieue/ia.oa ieene.noeoe.Aeueoa-eaoiaeooa?ao-AeA, ieiieue/ia a?eea.oaOeeo?ao-neioaca, iiieue/ie a?eea.oaAAeA iiieue/ia a?eea.oaIi?iaAIi?iaAIi?iaAIi?iaAEi?a92,12,0*45,22,4115,010,2*58,93,7515, 514,0*250,811,04,70,3***2,90,4A?iioaeaion85,63,4**72,01,986,97,1**62,34, 9450,010,8****420,010,04,20,3***3,40,4Noiaao?72,11,6***65,71,166,41,1*** 49,63,1510,019,2****500,014,26,90,3****3,00,4* – p<0,001; ** – p<0,01; *** – p<0,02; **** – p<0,05 I?e aiaeici ?acoeueoaoia aeineiaeaeaiiy aoee iaea?aeaii noaoenoe/ii aeinoiai?ii eiiieii ?aa?anieii caeaaeiinoi iiae cieaeaiiyi ?iaiia oa?iaioia oeeeeo E?aana i iiaeaeuaiiyi oa?iaioia aiaa?iaiiai aeieieico o aiaeiiaiaeieo iaeanoyo iiceo (p<0,001). Eiaoioei?ioe ei?aeyoeie aoee aiae'?iieie i eieeaaeeny aiae (r = -0,59) a noiaao?i iiceo i (r = -0,64) a aiiioaeaioni aei (r = -0.79) a ei?i aaeeeeo iiaeoeue. Io?eiaii aeaii iiaeooue naiae/eoe i?i i?eaii/aiiy i?ioeania ieenethaaeueiiai oinoi?eethaaiiy a aieiaiiio iiceo aianeiaeie ?icaeoeo ioaii? oa aiiieni? i?e iiceiaie aeenoee?eoeyoei? i eiiiainaoi?ia iiaeaeuaiiy aiaa?iaiiai aeieieico aeey caaacia/aiiy aia?aaoe/ieo i?ioeania ia iiia?aaeiueiio ?iaii. I?i aeieoaaiiy aa?iaieo oeeeeia ia?aoai?aiiy aetheice c iiaeaeuaiiyi aiaa?iaiiai iaoaaieicio naiae/eei oaeiae c?inoaiiy eiaoioei?ioo I/E c 19,8 aei 35,2. A oie aea /an o ei?i aaeeeeo iiaeoeue aeyaeaii cieaeaiiy eaeoaoo a iiieue/ea c 0,740,12 aei 0,310,11; a ii?oaaoo a iiieue/ea c 14,680,59 aei 11,930,66. Cieaeaiiy aiinoo ii?oaaoo i eaeoaoo i?e iaeii/aniiio c?inoaiii aeoeaiinoi aeieieioe/ieo i?ioeania iiaea naiae/eoe i?i ciaioaiiy caaacia/aiiy iiceo aia?aaoe/iei noano?aoii – aetheicith, yea aeieeei aianeiaeie ioaii?. Aeoeaiinoue eeth/iaeo oa?iaioia aeieieico iaeii/anii c?inoaea i a ne?iaaooei, i ieacii e?iai, i a a?eo?ioeeoao aenia?eiaioaeueieo oaa?ei. Oae, aiino AAe iiaeaeuoaaany aiaeiiaiaeii a 1,8; 3,4; 2,2 ?aca; EAeA – a 2,3; 2,6; 1,5 ?aca; AE – a 1,9; 2,7; 2,2 ?aca ii?iaiyii c ii?iith. Aiino aeieieioe/ieo oa?iaioia o iiceo i e?iai e?ieeeia c aenia?eiaioaeueiei aoa?ineea?icii iia'ycaii eiaoioei?ioaie ei?aeyoeie aiae (r = +0,65) aei (r = +0,79), i?e/iio a a?eo?ioeeoao (r = +0,65), a ieacii (r = +0,72), a ne?iaaooei (r = +0,79), ui naiae/eoue i?i neeueiee aca?iica'ycie iiae aiinoii aeieieioe/ieo oa?iaioia a iiceo i e?iai, iniaeeai ne?iaaooei, aenia?eiaioaeueieo oaa?ei. Oaeei /eiii, aeoeaiinoue aeieieioe/ieo i?ioeania o e?iai a?aeia?aaea? a aeayeie ii?i aiaeia?aaeaea ?iaaiue aeieieico a iiceo. Iaeii/anii ci c?ooaiiyie a oeeeeao aa?iaiiai oa aiaa?iaiiai aeieieico a aiiiaaiaoao iiceo aenia?eiaioaeueieo oaa?ei aeyaeyeinue iaeiie/aiiy IAeA i AeE. Oae, aiino IAeA (a ieiieue/e) a ei?i aaeeeeo iiaeoeue iiaeaeuoaaany c 49,5 + 2,3 a eiio?iei aei 89,6 6,4; a aiiioaeaioni c 44,4 3,4 aei 63,7 7,8; a noiaao?i iiceo c 40,2 2,6 aei 54,3 3,9. Aiino AeE (a ieiieue/e) c?inoaa a ei?i aaeeeeo iiaeoeue c 5,5 0,4 (eiio?ieue) aei 9,6 1,3; aiiioaeaioni – c 4,6 0,9 aei 7,9 1,2; noiaao?i iiceo – c 3,9 0,5 aei 5,1 1,2. E??i oiai, aeyaeaia i?eai?/aiiy ae?yeueiino? Na-AOOace iaia?ai o 1,5 ?aca (?0,001), ui ni?eyei i?aeaeuaiith ??aiy eaeueoe?th a 2 ?ace o ii??aiyii? c eiio?ieai (?0,01). Io?eiaii aenia?eiaioaeueii aeaii iiaeoaa?aeeee, ui aeoeaaoeiy IIE, i?i yeo naiae/eoue iiaeaeuaiiy aiinoo IAeA i AeE, /eieoue iiaiaoth/ee aieea ia oa?iaioe oeeeeo E?aana. I?e aeineiaeaeaiii oai?eo ia OIIE aeyaeeiny, ui ii?ooaiiy aiiaia?aaoe/ieo i?ioeania niieo/a?oueny c ?iceaaeaie aaaaoaoeaii? ?aaoeyoei? aiiainoaco oa aiiaieiiaoe/ieo ?aaeoeie. Iniiaiei eeiii/iei aeyaii aaaaoaoeaii? aeec?aaoeyoei? o oai?eo ia OIIE aoa neiae?ii aaaaoaoeaii? aeenoiii? (NAAe). Aiae?coth/e iniaeeaino? neiae?iio aaaaoaoeaii? aeenoiii? oa ?acoeueoaoe aeine?aeaeaiiy aaaaoaoeaii? ?aaeoeaiinoi, aaaaoaoeaiiai caaacia/aiiy ?icoiiai?, aiioeieii? oa oice/ii? aeiyeueiinoi, a oaeiae aeaii aa?iaoeieii? ioeueniiao?i? o oai?eo ia OIIE, aoee aeae?eaii o?e oeie ia?aa?ao NAAe. Noaoenoe/iee aiaeic iieacaa, ui eiaeiee c o?ueio oeiia ca niiaaiaeiioaiiyi neiiaoe/ii? ? ia?aneiiaoe/ii? /anoei aaaaoaoeaii? ia?aiai? nenoaie oa aaiiaeeiaii/ieo iieaciee?a ai?iaiaeii (p<0,005) aiae?iciyeeny iaeei aiae iaeiiai (?en.2). 1. Ia?iaiaioiee oei. Oa?aeoa?ecoaaany a?aenooi?noth ?icai?iooeo aaaaoaoeaieo e?ecia (AE), iayai?noth aiioe?eii-aaaaoaoeaieo nea?a iino?eiiai oa?aeoa?o, ae?aaeaiith neiiaoeeioii??th aai ia?aneiiaoeeioii??th c a??ia?aei?noth i?iya?a a?eueo i?ae 60 % a niieo/aii? c iaaeinoaoiueith aai ia?ae?o/aiith aaaaoaoeaiith ?aaeoeai?noth oa iaaeinoaoi?i aai iaaei??iei, ui oaeaeei aeniaaeo?oueny, ACAe. ?acoeueoaoe aa??aoe?eii? ioeueniiao???: AI0 = 48,65±1,92; O = 0,315±0,016; IBP = 154,4 ± 9,8, aea AI0 (a %) aiaeia?aaeaea aeoeaiinoue neiiaoe/ii?, O (a n) – ia?aneiiaoe/ii? /anoeie aaaaoaoeaii? ia?aiai? nenoaie, a IBP (o a.i.) (iiaeaen aaaaoaoeaii? ?iaiiaaae) – ?o niiaaiaeiioaiiy. . Ia?ieneciaeueiee c /anoeie AE (/ano?oa iaeiiai ?aco ia i?nyoeue). Oa?aeoa?ecoaaany aeieeiaiiyi AE ia?aaaaeii neiiaoi-aae?aiaeiaiai oa?aeoa?o c /anoioith a?ae 1-2 aei 5-8 ?ac?a ia i?nyoeue. O oai?eo oe??? a?oie niinoa??aaeany neiiaoeeioii?y c a??ia?aei?noth i?iya?a 70 % ? aeua, ia?ae?o/aia aai iaaeinoaoiy A? oa iaaei??ia caaacia/aiiy ooieoe?iioaaiiy na?oeaai-noaeeiii? nenoaie aai ACAe, yea oaeaeei aeniaaeo?oueny. Oa?aeoa?i? iieacieee aa??aoe?eii? ioeueniiao???: AI0 = 59,51±1,88; O = 0,331±0,019; IBP = 179,8 ± 10,5. . Ia?ieneciaeueiee oei ia?aa?ao c ??aeeeie AE (??aeoa iaeiiai ?aco ia i?nyoeue). Aei oeueiai oeio ie a?aeianee oai?eo ?c /anoioith ?icaeoeo AE ci?oaiiai aai neiiaoi-aae?aiaeiaiai oa?aeoa?o a?ae 1 ?aco ia 2-3 i?nyoe? aei 1-2 ?ac?a ia ??e. Oa?aeoa?ecoaaany noeeuei?noth aei neiiaoeeioii?? aai ia?aneiiaoeeioii?? c a??ia?aei?noth i?iya?a aei 60% a niieo/aii? c ii?iaeueiith aai i?aeaeuaiith A? oa aeinoaoi?i caaacia/aiiyi o?ce/ii?, ?icoiiai? ae?yeueiino? ? iaaei??iei oa aeinoaoi?i – aiioe?eii?. ?acoeueoaoe aa??aoe?eii? ioeueniiao???: AI0 = 44,95±1,16; O = 0,352±0,013; IBP = 127,3 ± 7,4. A?aoiaoth/e oi?aa?naeueio o/anoue aaaaoaoeaii? ia?aiai? nenoaie o ?aaoeyoe?? aiiainoaco oa aiiaie?iaco, ie i?iaiae?coaaee noai oea?aa?aeueii? oa oeaio?aeueii? aaiiaeeiai?ee, iieacieee a?iaia?aaoe/ieo oa iae?iaoii?aeueieo nenoai a caeaaeiino? a?ae aeae?eaieo oei?a aaaaoaoeaii? ?aaoeyoe??. Ia?oee oei oa?aeoa?ecoaaany iaea?eueoei o ii??aiyii? c ?ioeie oeiaie c?inoaiiyi caaaeueiiai /ano iiceiaiai e?iaiia?ao, i?e/iio iiaeiaaeoaaeeny oace II ? III, ui oa?aeoa?ecothoue i?ioiaeaeaiiy e?ia? /a?ac eai?ey?io n?oeo oa a?aeoie ii oea?aa?aeueieo aaiao. Cieaeoaaeany na?aaeiy oaeaee?noue iiceiaiai e?iaioieo, c?inoaa caaaeueiee noaeeiiee ia?eoa?e/iee iii?, iae/ano?oa (o 85% oai?eo) cono??/aany a?iie?iaoe/iee oei oeaio?aeueii? aaiiaeeiai?ee, niinoa??aaeiny i?aeaeuaiiy ai?noo OoA2, cieaeaiiy 6-eaoi-IAO1, iaea?eueo ae?aaeai? aoa?iaaii? ci?ie a e?i?aeiiio niaeo??, iaeieae/ee aioeieneaeaioiee caoeno ? iaeieae/a aia?aicaaania/ai?noue i?e iaeiaioiio eiiiainaoi?iiio ae?eie?c?. I?e II oeiia? niinoa??aaany iaea?eueo aenieee ?iaeaen PL 9a 1,5 ?aca aeuee o ii??aiyii? c eiio?ieai, ?<0,05, ui na?ae/eei i?i noeeuei?noue aei aia?iniacio, caaaeueiee /an iiceiaiai e?iaioieo iiaeiaaeoaaany ia?aaaaeii ca ?aooiie oace i?eoieo e?ia? ii ?io?ae?ai?aeueieo a?oa??yo (O1) a niieo/aiii c? cieaeaiiyi na?aaeiuei? oaeaeeino? iiceiaiai e?iaioieo. Iae?iaoii?aeueiee aeenaaeain oa?aeoa?ecoaaany ??ceei i?aeaeuaiiyi i?ani?ieo oa aeai?ani?ieo i?inoaaeaiaeeiia c? ci?uaiiyi a a?e i?ani?ieo, a?iaaiieo iiiiai?i?a, aiaeiiniei iiaeaeuaiiyi caoaeeeaeo iae?iaiiiieeneio. Aeey III oeio oa?aeoa?iei aoei iaeiaioa a?aeoeeaiiy a?ae eiio?ieueieo oeeo?, i?e/iio niinoa??aaeany iaeaeua aia?aicaaacia/ai?noue ? iaeaeuee ??aaiue aioeieneaeaioiiai caoenoo (oaae. 5). Iiaeia i?eionoeoe, ui aeacaiee oei ia?aaiao NAAe ca ?aooiie aaeaioeaii? ?iei ?iaeeeo AE aeicaiey? iaeaeiaaea caa?iaaoe noaaieueio aaiiaeeiaiieo i aaeaeaaoiee ?iaaiue aia?aicaaacia/aiiy. Oaaeeoey 5 Aaiiaeeiai?/i?, a?iaia?aaoe/i? oa iae?iaoii?aeuei? iieacieee o oai?eo ia OIIE a caeaaeiino? a?ae oeio aaaaoaoeaii? ?aaoeyoe??. IieacieeeOei aaaaoaoeaii? ?aaoeyoe??eiio?ieueIIIIII12345Caa. /an iice. e?ia. O, n12,76±0,4316,86±0,51*16,43±0,39*15,06±0,34*NOE, ni/n56,8±5,4534,8±5,9*38,9±7,3*51,3±3,5CINI, I.n.aei1107651608±82*1260±87*1132±35OOA2, ia/ie76,412,9137,1±13,4*127,1±14,9*96,3±9,8**6-eaoiIAO1, ia/ie146,75,1118,2±7,1*128,4±5,2**144,1±3,6IAO2, iiieue/e0,90,041,4±0,12**1,9±0,11*1,2±0,16IAA1, iiieue/e2,410,121,41±0,13*1,47±0,19*1,76±0,2O, iiieue/e4,53±0,156,8±0,23*6,2±0,16*5,4±0,18**EA, a.i. 2,03±0,114,12±0,14*3,92±0,12*2,48±0,34IAeA, ieiieue/e11,22±1,0315,1±1,016,2±1,110,9±1,1AeE, ieiieue/e156,4±5,3177,6±5,6*172,6±5,51*160,2±4,6Na a?eo., iiieue/e0,450,010,490,01*0,500,01*0,460,01SH-a?oie, iiieue/e10,4±1,39,3±0,69,1±0,610,7±0,9Aeooao?ii, iiieue/e0,515±0,010,472±0,011*0,483±0,012*0,84±0,04*Eaoaeaca, ieao/aHb3,05±0,113,11±0,253,07±0,193,33±0,11*12345Aethoaiao, iiieue/ie73,04±2,2869,1±2,878,09±2,16**71,2±2,6AAIE, iiieue/e31,61,226,11,8*25,21,5*31,81,4Aethoaiao/AAIE2,30,052,60,08*3,10, 1*2,230,1O??icei, ieiieue/e84,3±3,170,1±5,6*76,4±4,2**79,08±3,2AeIOA, iiieue/e17,07±2,412,9±2,1*13,5±2,8*15,4±2,6AeA, iiieue/e9,11±0,179,5±0,19**9,64±0,18**9,34±0,19IA, iiieue/e37,4±1,1342,2±3,244,4±3,5**40,1±2,28A, ieiieue/e3,0±0,213,56±0,154,21±0,11*3,2±0,19AOO, ieiieue/e625,5±15,1426,4±24,8*474,8±26,1*528,6±29,1**AAeO/AOO0,1770,0110 ,2960,01*0,2540,11*0,1990,009EAeA1+2, %77,349,054,865,0EAeA4+5, %6,320,515,011,9OOE, ieiieue//.a.aiae7,0±0,518,8±1,9**24,4±3,8**12,3±1,8*AE6,6±0,116,3±2,5*20 ,5±5,5*11,4±2,1*AAe0,75±0,032,51±0,39**3,91±0,91**1,61±0,21** – ?<0,01; ** – ?<0,001 a ii??aiyii? c eiio?ieai. Aeai? i?iniaeoeaiiai niinoa?aaeaiiy ca o?ueiia a?oiaie oai?eo a?aeiia?aeii aei aeae?eaieo oei?a NAAe i?aeoaa?aeeee, ui ??ci? oeie ia?aa?ao NAAe ni?eythoue ?icaeoeo oa i?ia?anoaaiith ??cieo aa??aio?a OIIE. Niinoa?aaeaiiy aaeiny i?ioyaii 5-8 ?ie?a ca 246 iniaaie, ye? no?aaeaeaee ia NAAe. C ieo o 41 oai?iai aoa ae?aaiinoiaaiee eiinoeoooe?eii coiiaeaiee NAAe, o 67 iaoe??io?a NAAe ?icaeioany ia oe? aiioe?eiiai no?ano, o 138 – ia oe? AeA I no. ?acoeueoaoe aiae?coaaeeny eeoa o oeo oai?eo, o yeeo c ii/aoeo aei e?ioey niinoa?aaeaiiy ia aeyaeyeiny o?ainoi?iaoe?? oeio ia?aa?ao NAAe. A i?ioean? niinoa?aaeaiiy oai?? ?iciiae?eeeeny oaeei /eiii: I oei ia?aa?ao NAAe – 83 oai?eo a?eii a?ae 42 aei 55 ?ie?a (c ieo 36 c OIIE, 47 – aac OIIE); II oei: 73 iaoei?ioe a a?oe? a?ae 40 aei 58 ?ie?a (c ieo 41 c OIIE,32 – aac iiceiai? aeenoee?eoeyoe??); III oei .– 92 oai?eo a a?oe? a?ae 41 aei 53 ?ie?a (c ieo 52 c OIIE, 40 – aac OIIE). Aiae?c aeaieo aeeiai?ee ee?i?/ieo neiae?ii?a oai?eo c OIIE iieacaa, ui i?e ia?oiio oeiia? ia?aa?ao NAAe iaea?eueoa c?inoaea /anoioa aanoeaoey?ii-aoaeoe/iiai neiae?iio (ia 37,4%) a ii?iaiyiii c iioeie oeiaie NAAe. I?e ae?oaiio oeiiai – ?ioaeaeooaeueii-iianoe/ieo (ia 32,9%) oa ?ooiaeo (ia 23,3%) ii?ooaiue. A i?e o?aoueiio oeiiai aiaenioie c?inoaiiy aeacaieo neiae?iiia neeaa 7,6%; 7,9% oa 8,7% aiaeiiaiaeii. Neiae aiaecia/eoe, ui a i?ioeani i?ia?anoaaiiy OIIE aeey ia?oiai oeio oa?aeoa?iith aoea iiyaa o?aiceoi?ieo ioaii/ieo aoae, a aeey ae?oaiai – oea?aa?aeueieo aiia?oiii/ieo e?ecia, ui iiaeoaa?aeaeoaaei ia?aaaaeiee ?icaeoie aeenoee?eoeyoei? aoa?ineea?ioe/iiai (i?e ia?oiio oeiiai NAAe) oa aiia?oiii/iiai (i?e ae?oaiio oeiiai) aaiacia. I?iniaeoeaia aeineiaeaeaiiy aecia/eei, ui iae/anoioa AeA ?icaeaaeany aai o?ainoi?ioaaeany c I aei II noaaei? i?e ae?oaiio oeiiai ia?aaiao NAAe (a 34,4% oa 56% aeiaaeeia aiaeiiaiaeii). I?e ia?oiio oeii iiyaa AeA ?a?no?oaaeany a 36% aeiaaeeia, a i?ia?anoaaiiy aei II noaaei? – a 36,1%. Iaeiaio ni?eyoeeaei uiaei ?icaeoeo aai iiaeeaeaiiy aeenoee?eoeyoei? aeyaeany o?ao?e oei NAAe, i?e yeiio iiai aeiaaeee AeA niinoa?iaaeeny eeoa a 12,5%, a i?ia?anoaaiiy – a 13,5% aeiaaeeia. Iiaa?oath/enue aei ?acoeueoao?a aeine?aeaeaiiy a?iaia?aaoe/iiai oa iae?iaoii?aeueiiai aiiainoaco, oaeo aeeiai?eo iiaeia iiynieoe iaea?eueoei aia?aiaeao?oeeoii i?e I oeiia? ca ?aooiie iineeaiiy iaia?aiii? iaoieia?? aiane?aeie aeoeaaoe?? IIE oa a?iien??, ?icaeoeo aoa?iaaiieo a?ia?e?iii?ioa?aeai?e, i?aeaeuaiiyi o?iiaienai-i?inoaoeeee?iiaiai ni?aa?aeiioaiiy, ye? ni?eythoue oaeaeeiio iiai?oaiith oea?aa?aeueii? aaiiaeeiaiiee. I?e II oei? – oea?aa?aeueia aeenoee?eoeyoe?y ?icaeaa?oueny ia oe? AA c i?aeaeuaiiyi ai?noo i?ani?ieo IA oa ae?aaeaii? neiiaoeeioiii?. Iiaeia i?eionoeoe, ui /ano? AE i?eaiaeyoue aei ia?aiai?oaeaiiy e?ia?ei-?aoeeoey?iiai eiiieaeno, oaeaeei? aeniaaeeeaino? eiiiainaoi?ieo iaoai?ci?a ? ye iane?aeie – cieaeaiiy ACAe. Oea aeeeeea? oaeaeeee ?icaeoie a?iien?? ? aia?aiaeao?oeeoo iia’ycaiee c aeieeiaiiyi ia?aeiii? oa aoi?eiii? ?oai?? i?ae /an oea?aa?aeueieo aiia?oiii/ieo e?ecia. Ia /anoioo c?inoaiiy iaa?ieiai/iiai aeaoioeeoo aieeaa? oaeiae aiaeiinia iiaeaeuaiiy ?iaiy aethoaiaoo. Aeaii aeeiaiiee iaa?ieiai/iiai noaoono oa oea?aa?aeueiiai e?iaiiaiao o oai?eo c III oeiii ia?aaiao NAAe iiaeoaa?aeeee iao? i?eiouaiiy aiaeiinii aaeaioeaii? ?iei ?iaeeeo ciioaieo AE. Aiaeic ?acoeueoaoia aeineiaeaeaiiy inia c iniiaieie oaeoi?aie ?eceeo oea?aa?iaaneoey?ii? iaoieiai? iieacaa, ui aaaaoaoeaii aeenooieoei? cono?i/aeeny a onio a?oiao: c iaoyaeaiith niaaeeiainoth – a 35% niinoa?aaeaiue; c o?iii/iei aiioeieiei no?anii – o 58%; c aiia?oieanoa?eiaii?th – a 23,5%; aiiiaeeiaii?th – a 27%. A a?oii c aeoeaiei niiniaii aeeooy aiaenioie aaaaoaoeaieo aeec?aaoeyoeie neeaa 1,5. Aiaeiinii aiiaia?aaoe/ieo i?ioeania aeyaeaia oaiaeaioeiy aei iiaeaeuaiiy ?iaiy aeieieioe/ieo oa?iaioia a ne?iaaooei e?iai inia c aiia?oieanoa?eiaii?th (p>0,05) oa aiiiaeeiaii?th (p>0,01). A a?oii c
o?iii/iei aiioeieiei no?anii niinoa?iaaeiny ai?iaiaeia c?inoaiiy aiinoo
eaeoaoo (?<0,05). Oei aeaii iiaeooue naiae/eoe i?i ii?ooaiiy aiiaia?aaoeee oa aaaaoaoeaii? ?aaoeyoei? aiiainoaco aaea ia aeieeiii/iiio aoaii oea?aa?iaaneoey?ii? iaoieiai?. ?acoeueoaoe aeine?aeaeaiiy aeaee i?aenoaao c aeei?enoaiiyi noaoenoe/iiai iaoiaeo oaeoi?iiai aiae?co aeiaanoe iiaeeea?noue i?iaiicoaaiiy ?icaeoeo oa ia?aa?ao OIIE c a?aooaaiiyi aaaaoaoeaieo, aaiiaeeiai?/ieo oa a?iaia?aaoe/ieo iieaciee?a. I?e noai?aiii i?ia?aie aeei?enoiaoaaeeny eeane/ii eiiieii aaaaoiaeii?ii ?aa?anieii caeaaeiinoi iiae aeineiaeaeoaaieie iieacieeaie aeey aeaeieaiiy iaeaieueo nooo?aeo oaeoi?ia, ui aieeaathoue iaeei ia iaeiiai. Aeyaeaii oaeei /eiii oaeoi?e aeaee iiaeeeainoue noi?iiethaaoe noaoenoe/i? caeaaeiino? aeey i?iaiicoaaiiy eiaeiiai c aea/aieo oaeoi??a o caeaaeiino? a?ae ?ioeo. Iaea?eueo aaaeeeaith, ia iao iiaeyae, ? ?aa?an?eia caeaaei?noue, yea ?ic?aoiaaia aeey na?aaeiuei? oaeaeeino? iiceiaiai e?iaioieo: Y = 65,83 - 19,11O1 + 11,36O2 - 0,99O3 - 0,42O4 + 0,05O5 + 0,07O6; aea: Y – na?aaeiy oaeaeeinoue e?iaioieo; O1 – iiaeaen ioeuenaoei?; O2 – ?iaaiue AOO; O3 – ?iaaiue neiiaoeeioiii?, ?ic?aoiaaiee ca aa?iaoeieiith ioeuenia?aiith; O4 – eieueeinoue aaaaoaoeaieo e?ecia i?ioyaii o?ueio iinyoeia; O5 – iiaeaen aaaaoaoeaii? ?iaiiaaae; O6 – caaaeueiee ia?eoa?e/iee noaeeiiee iii?. ?acoeueoaoe i?iaaaeaieo aeineiaeaeaiue aeathoue iiaenoaao cia?aceoe ?icaeoie iaa?ieiai/iiai aeaoioeeoo i?e OIIE oaeei /eiii (?en. 3). Ioaiiy oa aiiieniy, ui aeieeathoue i?e o?iii/iie iiceiaie aeenoee?eoeyoei?, i?eaiaeyoue aei cieaeaiiy aeoeaiinoi iioioiiae?iaeueieo oa?iaioia oa ieenethaaeueiiai oinoi?eethaaiiy, ui aeeeeea? cieaeaiiy aia?aicaiacia/aiiy iiceo. Aia?aiaeaoioeeo iineeth?oueny aianeiaeie iaia?aiii? iaoieiai?, yea ?icaeaa?oueny a ?acoeueoaoi aeoeaaoei? aieueii?aaeeeaeueiiai ieeneaiiy eiiiaeia. Iiaeaeuaiiy ?iaiy eaoaoieaiiiia oa iaaeii?ia neiiaoe/ia aeoeaaoeiy, ni?eyth/e aieueoei aia?aaoe/iei cao?aoai, iiaeeaeththoue aia?aiaeaoioeeo. A oiiaao o?iii/iiai aia?aiaeaoioeeoo ii/eia? aeyaeyoeny aenaeoioiene/iinoue aethoaiaoo (M.W.Riepe et al., 1995). Ianaiia?aae oea iia’ycaii c iiaeaeuaiiyi ?iaiy aethoaiaoo, yeee i?e cieaeaiie aia?aicaaacia/aiinoi iiaea aeeiioaaoe ?ieue aia?aaoe/iiai noano?aoo (I.TH.Eiinoaiaeyi ci niiaaao., 1997). E?ii oiai, a oiiaao ioaii? oi?iicii iaoaiicie no?aaeaeathoue ?aiioa, iiae caoaeeeai (Aeae.Aeeen, 1984), ui a iaoeo aeineiaeaeaiiyo aeyaeeiny cnoaii niiaaiaeiioaiiy a nenoaii aethoaiao/AAIE a aie aethoaiaoo. Oaeiio aeenaaeaino ni?ey?, iiaeeeai, oie oaeo, ui a oiiaao aia?aiaeaoioeeoo oa aeoeaaoei? IIE iiiiaiiiiieneaeaca ii/eia? aeeiioaaoe ia aeanoeao ?e aeith ii aeacaiiioaaiith AAIE (A.I.E?eaeaiianueeee, I.I.Ea?aaaiue, 1991; A.C.Ai?eii, 1985). Aianeiaeie aia?aiaeaoioeeoo ii?ooo?oueny aeiyeueiinoue aeiaeueiiai ia?aiinieea aethoaiaoo GLT-1, yeee caiinoue caea/oaaiiy iaaeeeoeo aethoaiaoo a oa?iiiaeue oa aeiaeueio eeioeio ii/eia? aeea/oaaoe eiai caiaeoe (M.Bouvier et al., 1992; I.D.Rothstein et al., 1992). Aeiaeueiee ia?aiiniee aethoaiaoo iiaea iioeiaeaeoaaoeny oaeiae aianeiaeie ieenethaaeueiiai no?ano (A.Volterra et al., 1994), yeee ia? iinoea i?e OIIE. Aethoaiao, aeoeaoth/e IIAeA-?aoeaioi?e, i?eaiaeeoue aei aeanoaaieicaoei? aioo?eoiueieeioeiiiai eaeueoei?aiai aiiainoaco (P.Ienner, 1994; D.I.Hoffman et al., 1994). Iiaeaeuaiith ?iaiy Na2+ ni?ey? oaeiae cieaeaiiy aeoeaiinoi aia?aicaeaaeii? Na-AOOace, aeyaeaia iaie a ei?i aaeeeeo iiaeoeue aenia?eiaioaeueieo oaa?ei, a oaeiae iineeaiiy aeeeaeo Na2+ c aiaeiieaciaoe/iiai ?aoeeoeoio aianeiaeie aei? aieueieo ?aaeeeaeia (L.Ver Donck et al., 1989). Caiaeii c eiioeaioei?th M.W.Riepe ci niiaaao. (1995) a oiiaao o?iii/iiai i?eaii/aiiy ieenethaaeueiiai oinoi?eethaaiiy aethoaiao aeeeeea? ii?ooaiiy o?ainii?oo Na+ oa aca?iiaei? iiae iae?iiaie e aei?th, ui eaaeeoue a iniiai caaeaaei iae?iiia. Iaeiie/aiiy eaeoaoo aianeiaeie aeoeaaoei? aiaa?iaiiai aeieieico oa ii?ooaiy aei? Na+/K+ ianino i?enei?th? iaa?ye oa caaeaaeue iae?iia. Oiaoi aia?aiaeaoioeeo ciaoiaeeoueny a oeaio?i iaoieiai/ieo eaioethaia oi?ioaaiiy iaa?ieiai/ii? naiiieiai? ia oei o?iii/ii? iiceiai? aeenoee?eoeyoei?. Oaeei /eiii, aeyaeaii ii?ooaiiy aia?aaoe/iiai iaoaaieicio, iia’ycaii c ioaii?th, aiiieni?th, iaia?aiiith iaoieiai?th, aeoeaaoei?th IIE, ia?aaaioaaeaiiyi Na oa aeenaaeainii iae?iiaaeiaoi?ieo aiiiieeneio i aaaaoaoeaii? ?aaoeyoei? iaa?oioiaothoue aeeth/aiiy a eiiieaen i?ioieaeoe/ieo oa eieoaaeueieo caoiaeia i?e OIIE aeoeaaoi?ia iaoaaieicio oa aia?aiooai?thth/eo i?ioeania, a?aoiaoth/e ?o iae?ii?ioaeoi?io aeith, a noeoiiinoi c iaia?aiinoaaieicoth/eie caniaaie, aioaaiiinoaie eaeueoeith, aaeuei?aieie iae?iaiiiieeneioaie, aaaaoio?iiieie i?aia?aoaie oa aioeaa?aaaioaie. AENIIAEE 1. O?iii/ii ii?ooaiiy iiceiaiai e?iaiiaiao aaaeooue aei cia/ieo ciii o nenoaii aiiaia?aaoe/iiai aiiainoaco. Aiiaia?aaoe/ii ciiie a naith /a?ao aieeaathoue ia oea?aa?aeueio aaiiaeeiaiieo i iineeththoue a?iien?th. 2. I?iaiaeiith eaieith aiiaia?aaoe/iiai aeenaaeaino i?e OIIE ? aia?aaoe/iee aeaoioeeo, yeee iia'ycaiee ic cieaeaiiyi i?ioeania ieenethaaeueiiai oinoi?eethaaiiy. 3. Ia ii/aoeiaie noaaei? OIIE ?icaeaathoueny eiiiainaoi?ii ?aaeoei? o aeaeyaei aeoeaaoei? i?ioeania aeieieico oa iaioiciiai oeeeeo ia?aoai?aiiy aoaeaaiaeia. Iiaeaeueoa i?ia?anoaaiiy aeenoee?eoeyoei? iia’ycaia c caaaeueiei i?eaii/aiiyi onio oeeeeia aia?aicaaacia/aiiy. 4. A oiiaao aeia?eiaioaeueii? aiiieni?, aeeeeeaii? aoa?ineea?icii, aiaeaoaa?oueny i?eaii/aiiy aeoeaiinoi iioioiiae?iaeueieo oa?iaioia, iaeaieueo ae?aaeaia a ei?i aaeeeeo iiaeoeue i aiiioaeaioni aenia?eiaioaeueieo oaa?ei. Cieaeaiiy ?iaiy oa?iaioia oeeeeo E?aana noi?iaiaeaeo?oueny aeoeaaoei?th aeieieioe/ieo oa?iaioia o aiaeiiaiaeieo iaeanoyo iiceo, ne?iaaooei, ieacii e?iai oa a?eo?ioeeoao. Iaeii/anii cieaeo?oueny aeoeai?noue AOOac, ui ni?aiaaea? c iaeiie/aiiyi i?iaeoeo?a IIE oa aioo??oiueiee?oeiiiai eaeueoe?th. 5. Aca?iiaiaeiioaiiy, yei iniothoue iiae nooiaiai aia?aaoe/iiai aeaoioeeoo, ii?ooaiiyi aaeaino a ieneaeaioii-aioeieneaeaioiie nenoaii, iaia?aiiith iaoieiai?th, cnoaii niiaaiaeiioaiiy iae?iiaaeiaoi?ieo aiiiieeneio i i?inoaoeeeeii-o?iiaienaiiai? ?iaiiaaae oa aaaaoaoeaiith aeec?aaoeyoei?th, ? aacenii ?icaeoeo o?iii/ii? iiceiai? aeecoee?eoeyoei? oa iaa?ieiai/iiai aeaoioeeoo ia ?? oei. 6. Ii?ooaiiy aiiaia?aaoe/iiai iaoaaieicio ciaoiaeeoue aiaeia?aaeaiiy ia AAA o aeaeyaei cieaeaiiy iiooaeiinoae niaeo?ia aeueoa- i aaoa-?eoiia oa c?inoaiiy iiooaeiinoi iiaieueiioaeeueiaeo ?eoiia. Aiieaioeoi?iia oa aenieiaiieiooaeii-aeec?eoii/ia aeoeaiinoue oa?aeoa?ecothoueny iaeaieueo nooo?aei aia?aiaeaoioeeoii. Ani aeaee ia?ieneciaeueii? aeoeaiinoi niieo/athoueny c iaeaeueie iieacieeaie eaeoaoo a ne?iaaooei e?iai. 7. Iaecia/iioee aia?aaoe/iee aeaoioeeo ?icaeaa?oueny o oai?eo ia OIIE c aeeoociith iaoieiai?th aieiaiiai iiceo o aeaeyaei ae?iaiiaiina?aaeeiaeo iioa?eoia i eaeeia?aico oa eeiii/iei neiae?iiii aeaiaioei?, ui iia’ycaii c i?eaii/aiiyi onio oeeeeia aia?aiooai?aiiy. 8. I?e ia?iaiaioiiio oeiiai ia?aaiao neiae?iio aaaaoaoeaii? aeenoii?? ?icaeaa?oueny iaenooo?aioee aia?aaoe/iee aeecaaeain ca ?aooiie oaeaeeiai i?ia?anoaaiiy oea?aa?aeueii? aeenoee?eoeyoei? aianeiaeie iiaeaeuaiiy o?iiaienai-i?inoaoeeeeiiiaiai niiaaiaeiioaiiy, oi?ioaaiiy aoa?iaaiieo aeeneiiii?ioa?aeaiie oa cieaeaiiy aioeieneaeaioiiai caoenoo. 9. Aiiaia?aaoe/ii ciiie i?e ia?ieneciaeueiiio ia?aaiaiai neiae?iio aaaaoaoeaii? aeenoii?? c /anoeie aaaaoaoeaieie e?ecaie iia’ycaii c iiai?oaiiyi aaiioee?eoeyoei? aianeiaeie iiaeaeuaiiy aiinoo i?ani?ieo i?inoaaeaiaeeiia, aiiaaiieo iiiiaiiiia oa cnoaii ni?aa?aeiioaiiy iae?iiaaeiaoi?ieo aiiiieeneio o aie caoaeeeaeo. 10. Iaeaeua aia?aicaaacia/aiinoue niinoa?iaa?oueny i?e ia?ieneciaeueiiio ia?aaiaiai neiae?iio aaaaoaoeaii? aeenoii?? c ?iaeeeie aaaaoaoeaieie e?ecaie. Oea iia’ycaii c? caa?aaeaiiyi aaeaeaaoii? aaaaoaoeaii? ?aaoeyoei? i oea?aa?aeueii? aaiiaeeiaiiee, iaeaeuiai ?iaiy i?inoaoeeeeiio oa aioeieneaeaioiiai caoenoo. ?iaeei ciioaii aaaaoaoeaii ia?ienecie aiaeia?athoue aaeaioeaio ?ieue. 11. Niinoa?iaathoueny aca?iica’ycee iiae oeiii ia?aaiao NAAe, iniaeeainoyie iae?iaoii?aeueieo, aiiaia?aaoe/ieo iieacieeia oa ?icaeoeii aa?iaioo aeenoee?eoeyoei?. Ia?iaiaioiee ia?aaia neiae?iio aaaaoaoeaii? aeenoii?? ni?e/eiy? ?icaeoie i i?ia?anoaaiiy OIIE ia?aaaaeii aoa?ineea?ioe/iiai aaiaco. Ia?ieneciaeueiee oei ia?aaiao c /anoeie aaaaoaoeaieie e?ecaie ni?ey? i?ia?anoaaiith aiia?oiii/ii? oai?iae i iia’ycaii? c iath iiceiai? aeenoee?eoeyoei?. 12. I?ia?aia i?ioieaeoeee ?icaeoeo o?iii/ii? iiceiai? aeenoee?eoeyoei? iiaeiia aeeth/aoe aeyaeaiiy inia c iani?eyoeeaei oeiii aaaaoaoeaii? ?aaoeyoei?, a oaeiae aeineiaeaeaiiy ia?aaiao neiae?iio aaaaoaoeaii? aeenoii?? o inia c oaeoi?aie ?eceeo oea?aa?iaaneoey?ii? iaoieiai?. 13. Aeiaaiinoeea, i?iaiicoaaiiy ia?aaiao oa aaeaeaaoia iaoiaaiaoe/ia oa?aiiy OIIE iio?aao? ioeiiee oa?aeoa?o aiiaia?aaoe/ii-aaaaoaoeaieo, aiiaia?aaoe/ii-iae?iaoii?aeueieo niiaaiaeiioaiue oa oeio aaaaoaoeaii? ?aaoeyoe??. 14. Oa?aiaaoe/ia ei?aeoeiy aiiaia?aaoe/ieo ciii i?e ii/aoeiaie noaaei? OIIE iiceoeaii aieeaa? ia oea?aa?aeueio aaiiaeeiaiieo iaaioue aac aeei?enoaiiy aaciaeoeaieo i?aia?aoia. 15. Anoaiiaeaia iae?ii?ioaeoi?ia ?ieue i?aia?ao?a-aeoeaaoi?ia aia?aiooai?aiiy. A ca’yceo c aeyaeaiei aieeaii aeoeaaoi??a iaoaaie?cio ia iineeaiiy i?ioean?a IIE aeiaaaeaia iaiaoiaeiinoue ?o aeei?enoaiiy a ii?aeiaii? c i?aia?aoaie aioeieneaeaioii? ae??. NIENIE INIIAIEO IOAEIEAOeIE CA OAIITH AeENA?OAOeII 1. Ii?iciaa I.A. ?ieue eciaiaiee aeiyia?aaoe/aneiai aiiainoaca a oi?ie?iaaiee o?iie/aneeo ia?ooaiee iicaiaiai e?iaiia?auaiey // Oe?. ainiee ineoiiaa?ieiai?. – 1997.– O.5. – Aei.2.– N.182-185. 2. Ii?iciaa I.A. Aaaaoaoeaii-aoii?aeueii niiaaiaeiioaiiy, ui oi?iothoue o?iii/ii ii?ooaiiy iiceiaiai e?iaiiaiao // Oe?. ainiee ineoiiaa?ieiai?.– 1997.– O.5.– Aei.2.– N.101-103. 3. Ii?iciaa I.A. Aaaaoaoeaiue aiiainoac e oi?ie?iaaiea o?iie/aneie oea?aa?aeueiie aeenoee?eoeyoeee i?e a?oa?eaeueiie aeia?oiiee// Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.–1998.– Aei.4.– N.67-71. 4. Ii?iciaa I.A. Ninoiyiea aeiyia?aaoe/aneiai aiiainoaca aieiaiiai iicaa e?ieeeia n yenia?eiaioaeueiie iae?iaaiiie iiaeaeueth aoa?ineea?ica // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.–1998.– Aei.4.– N.72-76. 5. Ii?iciaa I.A. Nia?aiaiiua i?aaenoaaeaiey i neiae?iia aaaaoaoeaiie aeenoiiee e niiniaao aai ea/aiey //Iaaeaeoia?iaeiue iaaeeoeeineee aeo?iae. – 1998. – ? 1. – N. 64-68. 6. Ii?iciaa I.A. 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O aeena?oaoe?? ia i?aenoaa? eiiieaeniiai aenia?eiaioaeueiiai, ee?i?/iiai, a?io?i?/iiai oa ?ino?oiaioaeueiiai aeine?aeaeaiiy aeiaaaeaii, ui i?ia?aeiith eaieith iaoiaaiaco o?ii?/ii? iiceiai? aeenoee?eoaeyoe?? ? aia?aaoe/iee aeao?oeeo, yeee aeieea? aiane?aeie ?oai??, oeaieiii? a?iien??, cieaeaiiy aeoeaiino? i?oioiiae??aeueieo oa?iaio?a ? niieo/a?oueny c iaia?aiiith iaoieia??th, ci?iaie a ieneaeaioii-aioeieneaeaioi?e nenoai? oa ni?aa?aeiioaii? iae?iiaae?aoi?ieo ai?iieeneio. Anoaiiaeai? aca?iica’ycee i?ae oeiii aaaaoaoeaii? ?aaoeyoe??, a?iaia?aaoe/ieie, iae?iaoii?aeueieie iieacieeaie oa ?icaeoeii aa??aioo oea?aa?aeueii? aeenoee?eoeyoe??. Aeyaeaii aaeaioeai? oa aeacaaeaioeai? uiaei ?icaeoeo ? i?ia?anoaaiiy o?ii?/ii? aeenoee?eoeyoe?? aa?iaioe aaaaoaoeaii-a?iaia?aaoe/ieo ni?aa?aeiioaiue. Aeiaaaeaia iiaeeea?noue i?iaiicoaaiiy o?ii?/ieo ii?ooaiue iiceiaiai e?iaiia?ao. Iaa?oioiaaia iae?ii?ioaeoi?ia ?ieue oa?aii?, ni?yiiaaii? ia iie?auaiiy a?iaia?aaoe/iiai aiiainoaco. Eeth/ia? neiaa: o?ii?/i? ii?ooaiiy iiceiaiai e?iaiia?ao, a?iaia?aaoe/iee aiiainoac, i?oioiiae??aeuei? oa?iaioe, aia?aaoe/iee aeao?oeeo. AIIIOAOeEss Ii?iciaa I.A. Aeiyia?aaoe/aneea eciaiaiey i?e o?iie/aneeo ia?ooaieyo iicaiaiai e?iaiia?auaiey. – ?oeiienue. Aeenna?oaoeey ia nieneaiea iao/iie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.15. – ia?aiua aieacie. – Oa?ueeianeee einoeooo oniaa?oainoaiaaiey a?a/ae, Oa?ueeia, 1998. A aeenna?oaoeee ia iniiaaiee eiiieaeniiai yenia?eiaioaeueiiai , eeeie/aneiai, aeioeie/aneiai e eino?oiaioaeueiiai enneaaeiaaiey aeieacaii, /oi aaaeouei caaiii iaoiaaiaca o?iie/aneie iicaiaie aeenoee?eoeyoeee yaeyaony yia?aaoe/aneee aeaoeoeeo, aicieeathuee a ?acoeueoaoa eoaiee, oeaiaaie aeiienee, nieaeaiey aeoeaiinoe ieoioiiae?eaeueiuo oa?iaioia e ni/aoathueeny n iaia?aiiie iaoieiaeae, eciaiaieai a ieneaeaioii-aioeieneaeaioiie nenoaia, a oaeaea a niioiioaiee iae?iiaaeeaoi?iuo aieiieeneio. Onoaiiaeaiu acaeiinayce iaaeaeo oeiii aaaaoaoeaiie ?aaoeyoeee, aeiyia?aaoe/aneeie, iae?iaoii?aeueiuie iieacaoaeyie e ?acaeoeai aa?eaioa oea?aa?aeueiie aeenoee?eoeyoeee. Auyaeaiu aaeaioeaiua e aeacaaeaioeaiua ioiineoaeueii ?acaeoey e i?ia?anne?iaaiey o?iie/aneie aeenoee?eoeyoeee aa?eaiou aaaaoaoeaii-aeiyia?aaoe/aneeo niioiioaiee. Aeieacaia aiciiaeiinoue i?iaiice?iaaiey o?iie/aneeo ia?ooaiee iicaiaiai e?iaiia?auaiey. Iainiiaaia iae?ii?ioaeoi?iay ?ieue oa?aiee, iai?aaeaiiie ia oeo/oaiea aeiyia?aaoe/aneiai aiiainoaca. Eeth/aaua neiaa: o?iie/aneea ia?ooaiey iicaiaiai e?iaiia?auaiey, aeiyia?aaoe/aneee aiiainoac, ieoioiiae?eaeueiua oa?iaiou, yia?aaoe/aneee aeaoeoeeo. ABSTRACT Morozova O.G. Bioenergetic changes in chronical disturbances of cerebral circulation. – Manuscript. A thesis presented for a doctor of medicine's degree in speciality 14. 01. 15 –nervous diseases – Kharkov institute of advanced medical studies. Kharkov, 1998. The leading aspect in pathogenesis of chronic brain discirculation is an energetical defitiency with appeare as result of ischemia, tissue hypoxy, decrease of activity in my tochondvial ensimes. The energetical defitiensy coesist with membranes pathology, changes in the oxidant-antioxidant system and with changes in the proportion between neuromediator aminoacids. It wasproved on the base of analisis of experemental, clinical, biochimical and instrumental dates. The correlation between tipe of vegetative regulation, bioenergetic neurogumoral dates and development of sevtant tipe of the cerebral dyscirculation was found. Vegetative-bioenergetical correlations velating to development and progress of chronical discirculation was obseved. The programe for proghosing of chronic disturbances in cerebral circulation was created. Patogenical treatment for improvement ofbioenergetical haemostasis was created. Key words: Chronical disturbances of cerebral circulation, bioenergeticcal haemostasis, mitochondrial ensimes, energetical deficit. I?aeienaii aei ae?oeo 29.10.98 ?. Oi?iao 60o84 1/16.Iai??. COPY LASER. Ae?oe ??cia?ao?/iee. Oiiai.-ae?oe.a?e. 2. Oe?. 150 i?ei. Cai. ? 53. I?ae?icae?e iia?aoeaiiai ae?oeo OAeIO. ??cia?ao. 310002, i.Oa?e?a, aoe.O?oica, 21

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