I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEEE IAe? IAAeE*II? ?AAA?E?OAOe?? OA EO?I?OIEIA??

A?EAN Aieiaeeie?a ?iiai?aia

OAeE 615.327:553,715]:616-092.19-001.28

Aaeueiaiaeoeai?noue i?aai?/ieo ?a/iaei

aiaee ”Iaooony” oa i?aeoiaee aei iiaeaethaaiiy ?o

iioiaeaeaiiy

14.01.33 — eo?i?oieia?y oa o?c?ioa?ai?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Iaeana — 1998

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI
Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe ?aan?aea Noaiai Aaneeueiae/,
?inoeooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI Oe?a?ie, caa?aeoaa/
a?aeae?eii aenia?eiaioaeueii? aaeueiaieia??.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee Ae?aaiie?aoeueea Iaoae?y Aieiaeeie??aia, Oe?a?inueeee IAe?
iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia??, aieiaiee iaoeiaee ni?a?ia?oiee
a?aeae?eaiiy a?aeiiaiiai e?eoaaiiy oai?eo oa?aiaaoe/iiai i?io?eth;

aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee Ee?oe/ Ethaeieea
I?ieii?aia, iaoeiai-i?aeoe/ia ia’?aeiaiiy “?aaa?e?oaoe?y”, caa?aeoaa/
aano?iaioa?ieia?/iei a?aeae?eaiyi.

I?ia?aeia onoaiiaa: E?einueeee ?anioae?eainueeee IAe? o?ce/ieo iaoiae?a
e?eoaaiiy oa iaaee/ii? ee?iaoieia?? ?i. ?.I. Na/aiiaa IIC Oe?a?ie,
ee?i?/iee a?aeae?e

Caoeno a?aeaoaeaoueny “ 25 “ a?oaeiy 1998 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.608.01 i?e Oe?a?inueeiio
iaoeiai-aeine?aeiiio ?inoeooo? iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia??
IIC Oe?a?ie (270014, Iaeana, Ea?iiioianueeee i?ia., 6).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oe?a?inueeiai IAe?
iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia?? (270014, Iaeana, Ea?iiioianueeee
i?ia., 6).

Aaoi?aoa?ao ?ic?neaiee “ 10 ” eenoiiaaea 1998 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii? ?aaee,

eaiaeeaeao iaaee/ieo iaoe,

noa?oee iaoieaee ni?a?ia?oiee
A.I. Aeieo???aa

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aaeeaaiiy oa?i?io «e?eoaaeueia i?ia?aeueia aiaea
Iaooony” i?aaii??ia eeoa /anoeiai, yeui aeoiaeeoe c oi?iaeueii? oiiae,
ui aei i?ia?aeueieo iaeaaeaoue aiaee, eio?? i?noyoue a naieiio neeaae?
nieae ia iaioa 2 a/e (A.A. Eaaiia, A.A. Iaa?aaa, 1964; I.A. Oea?oen,
TH.A. Aeaieeia, 1975). ?? iecueea i?ia?ae?caoe?y (0,7-0,8 a/e, oiaoi ia
??ai? i??nii? aiaee) nea?oaaea iiooe aaeueiaiaeoeaieo /eiiee?a a noi?iio
i?aai?/ieo neeaaeiee?a. Aaea a ia?o?e ienueiia?e caaaeoe? i?i Iaooonth
ii?yae c eiinoaoaoe??th ?? e?eoaaeueieo aeanoeainoae caa?oa?oueny oaaaa
ia eiia??iee oaeoi? oeeo aeanoeainoae: «… naeyie O?oneaaoey oa ?ioeo
n?e Aae?oe?? i’thoue aiaeo c aeii?oeaie iaooe aeey e?eoaaiiy aaaaoueio
caoai?thaaiue» (G. Rzaczynski, 1721). A ia?o?e iaoeia?e i?aoe?,
i?enay/ai?e Iaooon?, oaae neacaii i?i iaooo ye «ia iicaaaeaio cia/eiino?
neeaaeiao /anoeio» (T. Torosiewicz, 1836). A, aeania, caeiaaaeea i?i
ae?th/a ia/aei aiaee a?aeia?aaeaia ? o ?? iaca?. Iieiaeaiiy i?i
coiiaeai?noue e?eoaaeueii? ae?? Iaooon? ?? iaooiaeie neeaaeieeaie
?icaeiaia a ?iaioao M. Koch (1842), A. Unger (1843), A.N. Ao?ena?a e
I.A. Oaaea?iaie (1950). Ii?yae c oei, ai?iaeiaae a?eueo noie?oiueiai
ia??iaeo aeine?aeaeaiue, ye aieiai? e?eoaaeuei? /eiieee, ?icaeyaeaeeny:
niieiiiae?ai? ?a/iaeie (B. Radziszewski, 1881; T. Praschil, 1904; K.
Gerus, 1911); eaoe? n??/eno? aoaeaaiaee (G. Flaschen, 1931; Z. Orlowski,
1936; E.A. Aathi, O.O. Eaa/aiei, 1957; I.A. A?eee, 1975; ss.I. Eea/ae ?
?i., 1962; A.E. Aueiaa, A.A. Aieaaa, 1968); oaiiee (N.A. Oaie?i, 1951);
aae?aiae?iiiiae?ai? neiiaoii?iaoe/i? ?a/iaeie (O.A. Eo?eoaeui, 1963,
1965, 1968). I?ioa oe? oaa?aeaeaiiy /e i?eiouaiiy iiaoaeiaai? ia ia
i?yieo aeieacao, a ia caaaeueieo oyaeaiiyo i?i aoaeoe oeo /e ?ioeo
neeaaeiee?a Iaooon?, oiio iathoue eeoa ?noi?e/io oe?ii?noue.

Aaeueiaioa?aiaaoe/io ae?th Iaooon? ? ?? i?aai?/ieo neeaaeiee?a
ioe?ithaaee ca?aeii ci?i aiaeii-nieueiaiai iai?io (A.A. Aneiaiei, 1978,
1981), oiea?aco ? ae?o?aco (E.I. Aeaieeiaa e ae?., 1977), ia?oe?aeueii?
ooieoe?? ie?ie (A.E. Eaineay, I.Ae. Aanea, 1980), aeia/iooai?aiiy (I.E.
Aaai? e ae?., 1974; C.A. Aaa?eethe, 1980), i?ioean?a oeaieiiiai aeeoaiiy
oa oinoi?eethaaiiy a ia/?ioe? (E.E. AEaeeei, 1975). Canoinoaaiiy
nenoaiiiai i?aeoiaeo aeicaieeei io?eiaoe aaaaoi iiaeo aeaieo, eio??,
iaeiae, aeyaeeeny iaiaeiicia/ieie ? noia?a/eeaeie.

Aeine?aeaeaiiy I.N. ss?aiaiei ? ?i. (1983-1989) ?aaeoe??
aano?i-aioa?aeueii? iaie?aaoe/ii? aiaeie?eiii? nenoaie ia iaeii?aciaa ?
aeiaaio?eaaea aaaaeaiiy i?ia?aeueii? aiaee Iaooony aeicaieeei ei?aeoii
ioe?ieoe aaeueiaiaeoeaio ae?th ?? a?iiiniiey?iiai /eiieea, i?ioa, a
iiaeaeueoiio, aenia?eiaioaeueii anoaiiaeaii, ui aea?eueiaiiy
aano?i?ioanoeiaeueieo ai?iii?a coiiaeaia a?aae??ioieie iioieaie aiaee c
ii?iaeieie oeoieiai-eeoeiaiai o?aeoo a oeaieie aioo??oiueiai na?aaeiaeua
(N.A.?aan?aea, 1994), oiaoi a?iiiniiey?i?noue ? ianiaoeeo?/iei
aaeueiaiaeoeaiei /eiieeii i?ia?aeueii? aiaee Iaooony.

Ioaea, i?iaeaia aeyniaiiy ?ie? i?aai?/ieo neeaaeiee?a aiaee Iaooony a ??
aaeueiaiaeoeaiino? caeeoa?oueny aeooaeueiith. Ia nueiaiaei? anoaiiaeaii,
ui aaoiooiii? i?e?ii?aai?cie aiaee Iaooony caeaoi? ?oeioaaoe ??
i?aai?/i? ?a/iaeie, iaeiae ooai?aiiy a?ieia?/ii aeoeaieo ?a/iaei (AA?)
oeyoii i?e?iaii? a?io?ainoi?iaoe?? eeoa ia?aaeaa/aeiny (N.A.
E?aoaieiieeiaa, 1962; A.E. Eaanieeia e ae?., 1978, 1981; A.A. Aneiaiei,
1981).

Caycie ?iaioe c iaoeiaeie oaiaie. Iaoeiai-aeine?aeia ?iaioa
aeeiioaaeanue a ieaiiaiio ii?yaeeo o a?aeae?e? ii aea/aiith iaoai?ci?a
o?c?ieia?/ii? ae?? i?ia?aeueieo aiae oa eaai?aoi??? aenia?eiaioaeueii?
aaeueiaieia?? a?aeae?eo o?c?ieia?? aiaeii-nieueiaiai iai?io ?inoeoooo
o?c?ieia?? ?i. I.I.Aiaiiieueoey IAI Oe?a?ie ? ca”caia c oaiaie:
”Eco/aiea ?iee ioaeaeueieo eiiiiiaioia aiae oeia Iaooony, iaoaieciu eo
oeceieiae/aneiai e ea/aaiiai aeaenoaey” , N ain. ?aaeno?aoeee
01850003843, oeo? oaiu 2.35.7.7.,”Eco/aiea aeieiae/aneie aeoeaiinoe e
oeceieiae/aneiai aeaenoaey i?aaie/aneeo aauanoa aiaeu Iaooony”, N ain.
?aaeno?aoeee 01880009978, oeo? oaiu 2.36.1.1.,”Eco/eoue
oeceieiae/aneoth aeoeaiinoue ?yaea ieia?aeueieo aiae iiauo enoi/ieeia
n oeaeueth yenia?eiaioaeueiiai iainiiaaiey eo ea/aaiiai aeaenoaey” ii
i?ia?aiia AEIO N 348 io 30. 07.86, N ain. ?aaeno?aoeee
01870026029, oeo? oaiu 2.36.5.3.

Iaoa aeine?aeaeaiiy. ?icoe?aiiy niaeo?o iaoiae?a ioe?iee
aaeueiaiaeoeaiino? i?aai?/ieo ?a/iaei aiae oeio Iaooony, ?ic?iaea
i?aeoiae?a aei iiaeaethaaiiy ?o iioiaeaeaiiy c iaoith ooi/iaiiy aeayeeo
noi??i iaoai?cio ?oiuei? ae?? oa ?aeaioeo?eaoe?? aiae iiaia?aee?eoeo
?iaeiaeu oa naa?aeeiaei ia i?aaeiao i?eiaeaaeiino? aei oeio Iaooony.

Caaea/? aeine?aeaeaiiy. O a?aeiia?aeiino? c iaoith aeine?aeaeaiiy aoee
iinoaaeai? ianooii? caaaeaiiy.

1. Aeyaeoe niaoeeo?/i? oa?iaioaoeai? a?i?iaeeeaoi?e aeey aiae oeio
Iaooony. Aea/eoe caeaaei?noue i?ae ??aiyie oa?iaioaoeaii? aeoeaiino?
aiae ??cieo naa?aeeiaei oa e?euee?noth i?e?ii?aai?ci?a ??cieo
o?c?ieia?/ieo a?oi oeeo aiae.

2. Aea/eoe aieea aiae oeio Iaooony ia aeoeai?noue a?ae?ie?oe/ieo
oa?iaio?a oeoieiai-eeoeiaiai o?aeoo aeciaaiiiai oa iaia?aiiiai
iioiaeaeaiiy. C”ynoaaoe aieea ie?aieo a?oi i?aai?/ieo ?a/iaei
e?eoaaeueieo aiae oeueiai oeio ia eaoae?oe/io aeoeai?noue a?ae?ieac.

3. Ioe?ieoe aieea i?e?iaeieo oa aio?iiiaaiieo oaeoi??a ia
aaeueiaiaeoeai?noue aiaee Iaooony naa?aeeiaei O?oneaaaoeueeiai
?iaeiaeua c aeiiiiiaith niaoeeo?/ieo a?inaini??a.

4. Aea/eoe aieea aiaee Iaooony i?e o?eaaeiio iaiithaaii?
oaa?ei ia oaaioeeoa?io aeoeai?noue a?aioeioeeo?a oa ?aaeoeai?noue
i?aai?a ?ioiii? nenoaie. I?iaanoe ii??aiyeueio ioe?ieo
?ioiiiiaeoethth/i? ae?? a?ae?ioiaii? oa a?ae?io?eueii? o?aeoe?e
e?io?e?caoo e?eoaaeueii? aiaee ia oaaioeeoa?io aeoeai?noue
a?aioeioeeo?a aenia?eiaioaeueieo oaa?ei.

5. ?ic?iaeoe caaaeuei? i?eioeeie io?eiaiiy a?oie aaeueiaiaeoeaieo
?a/iaei , i?eoaiaiieo aiaeai oeio Iaooony, oeyoii i?e?iaii?
a?ioaoiieia?? ae?iuoaaiiy anioe?eiaaii? eoeueoo?e
aoaeaaiaeaiueieenethth/eo i?e?ii?aai?ci?a ia aoaeaaiaeiaa?e ne?iaei?.

6. I?iaanoe ii??aiyeueio ioe?ieo aieeao i?iaeoeo?a a?io?ainoi?iaoe??
iciea?eoo ia iaia?aii? ?iio?ainii?oi? AOOace aioa?ioeeo?a oa ia
nenoaio ianiaoeeo?/iiai ?ioiiiai caoenoo c ae??th iaoeaii? aiaee
Iaooony.

7. Iaa?oiooaaoe ? c”ynoaaoe cia/aiiy i?e?iaiiai oeaiico a iaoai?ci?
ae?? i?ia?aeueieo aiae oeio Iaooony , aeaoe ioe?ieo io?eiaiei
?acoeueoaoai aeey aaeueiaieia?? .

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Ia iniia?
ee?i?ei-a?io?i?/ieo oa i?e?ia?ieia?/ieo iaoiae?a aia?oa ?ic?iaeaii
a?inaini?i? iaoiaee ioe?iee aaeueiaiaeoeaiino? i?ia?aeueii? aiaee
Iaooony in vitro . ?icoe?aii iaa?? a?ioano?a aeey ioe?iee
aaeueiaiaeoeaii? ae?? aiae oeueiai oeio.

Aia?oa anoaiiaeaii, ui i?e?iaia eaeoaoaeaa?ae?iaaiacia aeoeai?noue ?
a?ieia?/iei ?iaeeeaoi?ii aiaee Iaooony, coiiaeaia aeeoo?ae?yeuei?noth
noeueoao?aaeoeoth/eo aaeoa??e, cie?aia Desulfovibrio desulfuricans.

Aia?oa c”yniaaiee iaoai?ci ae?? ie?aieo a?oi i?aai?/iiai eiiieaeno
e?eoaaeueieo i?ia?aeueieo aiae ia aeoeai?noue a?ae?ie?oe/ieo oa?iaio?a
oiieiai eeoa/ieea (aeueoa-ai?eace oa iaia?aiii? Na,K-AOOace).

Aia?oa anoaiiaeiii iiaeoethth/o ae?th aiaee Iaooony ia oaaioeeoa?io
caeaoi?noue a?aioeioeeo?a o ee?i?oe? oa aenia?eiaio?.

Aia?oa a?aeoai?aii iaeei ?c eeth/iaeo aaeueiaiaoaeo?a i?ia?aeueii?
aiaee — aaeueioaaiiy aeoeaiino? ?iio?ainii?oieo AOOac ea?aiiiaeie
eeneioaie, io?eiaieie oeyoii i?e?iaii? a?io?ainoi?iaoe??..

Iaoiaeii a?ioaoiieia?/iiai iaa?iiaaeaeaiiy iaoaaie?o?a anioe?eiaaii?
eoeueoo?e aoaeaaiaeaiueieenethth/eo i?e?ii?aai?ci?a aiaee Iaooony
io?eiaii aaeueiaiaeoeai? ?a/iaeie oa a?aeoai?aii aaeueiaiaoaeoe ia
oa?iaioieo a?inaini?ao oa i?e aaaaoi?aciaiio iaaeoiaeaeaii? a
i?aai?ci in vivo.

I?aeoe/ia cia/aiiy. Io?eiai? ?acoeueoaoe ? iniiaith a?ieia?/ii?
?aeaioeo?eaoe?? i?ia?aeueieo aiae oeio Iaooony ca?aeii ?o aeanii?
oa?iaioaoeaii? aeoeaiino?. ?ic?iaeaii iaoiaee oa?iaioaoeaiiai
a?ioanooaaiiy i?aai?/ieo ?a/iaei e?eoaaeueieo i?ia?aeueieo aiae c iaoith
?icoe?aiiy niaeo?o ?o ?aeaioeo?eaoe?eieo oa?aeoa?enoee.

Cai?iiiiiaai? a?inaini?i? iaoiaee iiaeooue aooe aeei?enoai? aeey
aea/aiiy a?ieia?/ii? aeoeaiino? neeaaeieo i?aai?/ieo noi?oae,
a?iiiaeaeae, aiiaiiaoe/ieo cania?a oa i?ia?ioee?a, a oaeiae aeey ioe?iee
aieeao aio?iiiaaiieo oa i?e?iaeieo /eiiee?a ia ??aaiue
aaeueiaiaeoeaiino? e?eoaaeueieo neaaii?ia?ae?ciaaieo aiae . C ?o
aeiiiiiaith ei?aeoii i?iaaaeaii iii?oi??ia ci?i e?eoaaeueii? ae??
i?ia?aeueii? aiaee Iaooony ??cieo naa?aeeiaei O?oneaaaoeueeiai
?iaeiaeua oa ?aeaioeo?eiaaii aiaee oeio Iaooony na?aae iiaeo
naa?aeeiaei.

A?ioaoiieia?/ii iaea?aeaii a?oio aaeueiaiaeoeaieo i?aai?/ieo ?a/iaei
i?ia?aeueii? aiaee Iaooony, ui aeicaiey? caaacia/eoe oe?eani?yiiaaio
iiaeeo?eaoe?th aaeueiaioa?aiaaoe/ii? oe?iiino? oe??? oi?eaeueii?
e?eoaaeueii? aiaee.

Cai?iiiiiaaii oa ai?iaaaeaeaii a i?aeoeeo ?aeiiaiaeaoe?? uiaei uaaey/eo
iaoiae?a i/enoee e?eoaaeueieo aiae c iaoith caa?aaeaiiy aaeueiaiaeoeaieo
i?aai?/ieo ?a/iaei oa aaiaoe/iiai oiiaeo i?e?iaiiai oeaiico
O?oneaaaoeueeiai ?iaeiaeua.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aecia/aia iaoa oeueiai
aeine?aeaeaiiy, i?iaiae?ciaaia iaoeiaa e?oa?aoo?a c aea/aii? i?iaeaie.
?ic?iaeaii a?inaini?i? iaoiaee, iaoai?cie ae?? oa i?e/eii? oaeoi?e ?o
iiaeeo?eaoe?? a?oiaie i?aai?/ieo ?a/iaei aiaee Iaooony c”yniaai?
naiino?eii. Ia?aaaaeia a?eueo?noue aenia?eiaio?a, i?enay/aia aea/aiith
?ioiiiiaeoethth/i? ae?? aiaee Iaooony i?iaaaeaia iniaenoi. Aaoi?
naiino?eii ?ic?iaeea i?aeoiaee oa ciiaeaethaaea a?ioaoiieia?th
iaea?aeaiiy a?ieia?/ii aeoeaieo ?a/iaei aeine?aeaeoaaii? aiaee.

?acii ?c N.A.?aan?aeith aeae?eaii i?iaeoeoe i?e?iaii? a?io?aini?iaoe??
iciea?eoo iaoiaeii e?io?eueii? nooee oa a?aeoai?aii iniiai?
aaeueiaiaoaeoe aiaee Iaooony a aeine?aeao in vivo.Aeine?aee c
?a?no?aoe??th aeoeaiino? aeaaeaiueeeo i’yc?a i?iaaaeai? ?acii c A.I.
Caai?iaeitheii oa ?.ss. Aa?aei. Noaoenoe/ia ia?iaea ?acoeueoao?a, ?o
ocaaaeueiaiiy, ?ioa?i?aoaoe?y oa aeniiaee cae?eniai? naiino?eii.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ?iaioe
ii?eethaeiaii ia: XXIX
Ananithci?e ia?aae?, i?enay/ai?e noaio ? ia?niaeoeaai ?icaeoeo
iaoiaee/ieo iniia o?i?/iiai ? a?ieia?/iiai iii?oi?eiao iiaa?oiaaeo aiae
noo? (?inoia-ia-Aeiio, aeiaoaiue 1987); Ananithci?e eiioa?aioe??
?inoeoooo aaieia?? AI O?N? (Ee?a, /a?aaiue 1988 ); ?anioae?eainuee?e
iaoe.-i?aeo. eiio. «Oeyoe ciaioaiiy aio?iiiaaiiiai aieeao ia i?e?iaei?
?ano?ne» (Iaeana, aeiaoaiue 1990); ?aa?iiaeuei?e iaoe.-i?aeo. eiio.
«Aeooaeueiua aii?inu naiaoi?ii-eo?i?oiiai ea/aiey» (Oaeai?iae, eenoiiaae
1990); II ?anioae?eainuee?e iaoe.-i?aeo. eiio. aea?iaoieia?a ?
eo?i?oieia?a «Eo?i?oi? oaeoi?e I?eea?iaooy a iaaee/i?e ? nioe?aeuei?e
?aaa?e?oaoe?? oai?eo aea?iaoicaie» (Euea?a, aa?anaiue 1991 );
iaoe.-i?aeo. eiio. «Iia? i?aeoiaee aei i?aai?caoe?? ? i?iaaaeaiiy
e?eoaaiiy, ?aaa?e?oaoe?? ? ?ae?aaoe?? a oiiaao eo?i?oo»(O?oneaaaoeue,
aeiaoaiue 1995); iaoe.-i?aeo. eiio. «Iaaee/ia ?aaa?e?oaoe?y iioa?i?eeo
aiane?aeie *i?iiaeeuenueei? eaoano?ioe» (O?oneaaaoeue, o?aaaiue 1996);
?icoe?aiiio can?aeaii? eaai?aoi??? aenia?eiaioaeueii? aaeueiaieia??
a?aeae?eo o?c?ieia?? aiaeii-nieueiaiai iai?io ?inoeoooo o?c?ieia?? ?i.
I.I. Aiaiiieueoey IAI(O?oneaaaoeue, aa?anaiue 1997); can?aeaii? naeoi?o
a?noea?aeueieo nenoai ?inoeoooo o?c?ieia?? ?i. I.I. Aiaiiieueoey IAI
(Ee?a, eenoiiaae 1997 ).

Ioae?eaoe??. ?acoeueoaoe aeena?oaoe?? iioae?eiaai? a iiiia?ao??, 8
noaooyo o iaoeiaeo aeaeaiiyo, 9 oacao c’?cae?a oa eiioa?aioe?e.

No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 163 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny ?c anooio, aiae?oe/iiai iaeyaeo
e?oa?aoo?e, iieno iaoiaeee aeine?aeaeaiue, 5 ?icae?e?a ?acoeueoao?a
aeanieo aeine?aeaeaiue, ?o iaaiai?aiiy oa aeniiae?a, nieneo 317
aeei?enoaieo e?oa?aoo?ieo aeaea?ae. Aeena?oaoe?y i?noeoue 34
oaaeeoe? oa 12 ?enoie?a.

CI?NO ?IAIOE

Aeine?aeaeoaaee i?ia?aeueio aiaeo Iaooony (IAI) naa?aeeiaei (na) 1- II,
8-II, 16-II, 21-I O?oneaaaoeueeiai ?iaeiaeua, a oaeiae
neaaii?ia?ae?ciaai? aiaee oeueiai oeio na. 18-EAe No?aeieoeueeiai
?iaeiaeua, na. 123 (Iii??ee), na. N 2 ? N 3 (Aooa), oa aeaea?aea N 11
(THcy). A?aea?? i?ia aiaee i?iaiaeeee a noa?eeuei? oeaeiie ia’?iii 0,3
e, ye? aeine?aeaeoaaee ia i?ci?oa 3 aiaeei c iiiaioo a?aeai?o. A ie?aieo
na??yo aeei?enoiaoaaee IAI i?ney 3-30-aeaiiiai caa??aaiiy a aa?iaieo /e
aiaa?iaieo oiiaao. Ai?no eenith eiio?iethaaee iioaioe?iiao?e/ii
aiae?caoi?ii «Tlenomierz» (Iieueua). A /anoei? aeine?ae?a c aiaee
iiia?aaeiuei aeaeaeyee i?e?ioei?o c aeiiiiiaith aaeoa??aeueiiai o?eueo?o
OII2-1000 oa iaia?aie «??ii?-4». I?iae caa??aaee a aa?iaoe/ieo ?ieinoyo
i?e 9iN ai?iaeiaae 30 ae?a.

Iaoiaee aeine?aeaeaiiy. Aea/aiiy aaoiooiiii? i?e?ioei?e IAI oa ??
niaoeeo?/ieo o?c?ieia?/ieo a?oi i?iaiaeeee ca?aeii iaoiaee/ieo
?aeiiaiaeaoe?e. Aecia/aiiy caaaeueii? e?eueeino? aaeoa??e i?iaiaeeeinue
iaoiaeii i?yii? i?e?ineii?? o oaciai-eiio?aniiio cia?aaeaii?. Aeyaeaiiy
e?eueeino? i?e?ii?aai?ci?a o?ueio niaoeeo?/ieo o?c?ieia?/ieo a?oi
i?iaiaeeeinue iaoiaeii oeo??a ia aeaeoeaieo aeeaeeueieo na?aaeiaeuao. A,
naia, aoaeaaiaeaiueieeneth/? i?e?iae (AII) aeae?eyee ia na?aaeiaeu?
Oaoniia, noeueoao?aaeoeoth/? i?e?iae (N?I) — ia na?aaeiaeu? Ooo?i, a
o?iiiaieene? — ia na?aaeiaeu? Aae???iea. Ioe?iea aeeoo?ae?yeueiino?
i?e?ii?aai?ci?a cae?enithaaeanue ii ciai?oi?o iciaeao ?inoo,
eoeueoo?aeueieo oa oa?iaioaoeaieo aeanoeainoyo.

Aeey iiaeaethaaiiy aaiaco a?ae?io?eueieo niieoe aiaee Iaooony AII
eoeueoeaoaaee c aoaeaaiaeiaaith ne?iaeiith iaooiaiai iioiaeaeaiiy:
aiaeiai?nii? ii?iaee o?oneaaaoeueeiai ?iaeiaeua IAI, aeeeueiiai
iciea?eoo Ai?eneaanueeiai ?oaeiiai oi?aae?iiy, ai?eneaanueei? iaooe ?
o?i?/ii /enoiai ia?ao?iiaiai ianea. Caaaa/aio eoeueoo?o AII io?eioaaee
oeyoii aaaaoi?aciaeo ia?an?a?a ia na?aaeiaeua Oaoniia c aoaeaaiaeiyie.
Eoeueoo?aeueio ??aeeio (E?) e?io?e?coaaee ia onoaiiaoe? LZ- 9,2.?c
nooiai caeeoeo i?ia?aeueieo oa i?aai?/ieo eiiiiiaio?a aiaeiith
aeno?aeoe??th aeae?eyee a?ae?io?euei? i?aai?/i? ?a/iaeie (I?).

A IAI, E? ? aiaeieo aeoyaeeao aoaeaaiaei?a aecia/aee ai?no aaeoa??e,
eiioeaio?aoe?th i?aai?/iiai aoaeaoeth (Ni?a), a?ooi?a, ai?i?a,
ea?aiiiaeo eeneio, eenith, aaee/eio Eh-iioaioe?aeo ? pH.

Oanooaaiiy aaeueiaiaeoeaiino? IAI, E? ? aiaeieo aeoyaeie aoaeaaiaei?a
cae?enithaaee in vitro oa in vivo. In vitro aeine?aeaeoaaee
eaeoaoaeaa?ae?iaaiacio (EAeA) aeoeai?noue iaoiaeii Aa?aiae??a,
aeoeai?noue aaeoa??aeueii? aeueoa-ai?eace iaoiaeii Ni?oa ? ?iy,
aeoeai?noue Na,K-AOOace aioa?ioeeo?a uo?a iaoiaeii Cortas a
iiaeeo?eaoe?? I.I. Oa?eaiiai?, a oaeiae nei?ioeeao oa aeaeo?e/io
aeoeai?noue ?cieueiaaieo aeaaeaiueeeo i’yc?a (AI), (I.N. ss?aiaiei e
ae?., 1989). A aeine?aeao ia uo?ao ?n vivo aeine?aeaeoaaee aeoeai?noue
o?e?aeeii? caoenii? nenoaie i?aai?cio: ?ioiii?, i?e?iniiaeueii?
iiiiieneaaiacii? (IIN) ia/?iee oa eaiaeueoeaai? nae?aoi?ii-o?ainii?oii?
(ENON) ie?ie. Noai ?ioiii? nenoaie ioe?ithaaee ii ai?noo eaeeioeeo?a o
e?ia?, oaaioeeoa?i?e aeoeaiino? iaeo?io?e?a, ian? naeac?iee, iieacieeao
eaeei-, oa nieaiia?aie (I.A. Aaca?iiaa, 1982). I?i aeoeai?noue IIN
noaeeee ii o?eaaeino? aa?a?oo?aoiiai nio; ??aaiue ENON ioe?ithaaee ii
oaeaeeino? aene?aoe?? oaiie?ioo c na/ath, aaaaeaiiai aioo??oiueii’yciai
(N.A. ?aan?aea, 1994).

Aaeue-o?iiaoia?ao?th a?ae?io?eueieo I? IAI, E? oa aiaeieo aeoyaeie
aoaeaaiaei?a cae?enithaaee ia iaeo?aeueiiio naoaaeaen? G-10 (N.A.
?aan?aea, 1994).

AEe?i? eeneioe (AEE) c IAI ? E? aeae?eyee iaoiaeii aeno?aeoe??
oei?ioi?iii i?e ?I 3,0-4,0. ?o noia?iee ai?no aecia/aee ii
eiioeaio?aoe?? NIII-a?oi. Aeey ?aeaioeo?eaoe?? ?iaeea?aeoaeueieo AEE
o?aeoe?th AEE c E? aiae?coaaee ia aaci-??aeeiiiio o?iiaoia?ao? (EOI-
8IAe) c iieoi’yii-?ii?caoe?eiei aeaoaeoi?ii. A?ieia?/io aeoeai?noue AEE,
aeeo/aieo c IAI ? E?, a oaeiae i??enoeiiai? eeneioe (N14), ye
i?aaenoaaieea ea?aiiiaeo (aee?ieo) eeneio IAI, aea/aee ii ae?? ia
Na,K-AOOaco ? i?aia?ao AI.

Noaoenoe/ia ia?iaea oeeo?iaiai iaoa??aeo i?iaaaeaia ca e?eoa??yie t
Student, T Wilcocson, U Wilcocson-Mann-Witney. Ei?aeyoe?eii-?aa?aneaiee
aiae?c cae?eniaii ia eiii’thoa?? ca i?ia?aiith Costat.

?acoeueoaoe aeine?aeaeaiiy. 1. I?e?iaia eaeoaoaeaa?ae?iaaiacia
aeoeai?noue — ?iaeeeaoi? aiae oeio Iaooony. Anoaiiaeaii, ui ??aaiue
EAeA o an?o aeine?aeaeoaaieo aiaeao ei?aethaaa ?c /enaeuei?noth
noeueoao?aaeoeoth/eo i?e?ii?aai?ci?a. Caaaeueia aeoeai?noue EAeA
(iiieue/e*aiae) o aiae? na. 18-EAe neeaaeaea 16512, o aiae? Iaooony
(O?oneaaaoeue) — 12410, o aiae? na. 123 — 855, oiae? ye o iiaa?oiaaeo
aiaeao — 202. *enaeuei?noue niaoeeo?/ieo i?e?ii?aai?ci?a-
aoaeaaiaeaiueieenethth/eo oa noeueoao?aaeoeoth/eo (oen/e), aen?yieo c
aiaee na. 18-EAe, neeaaeaea 4,3, aiaee Iaooony (O?oneaaaoeue) — 0,96,
aiaee na. 123 — 0,34. I?e oeueiio anoaiiaeaii, ui iaeaeua aeoeai?noue
EAeA i?eoaiaiia a?oi? aiaa?iaieo noeueoao?aaeoeoth/eo aaeoa??e, a
naia, Desulfovibrio desulfuricans.

Anoaiiaeaii, ui ai?no N?I oa AII o IAI na. 21-I na. 1-II nooo?ai
ciaiooaaany o aaniyii-in?ii?e ia??iae, aeinyaath/e i?i?ioio ia ii/aoeo
aa?aniy c iinooiiaei i?aeaeuaiiyi aei n?/iy. Oey ae oaiaeaioe?y aeyaeaia
aeey caaaeueii? EAeA-aeoeaiino? i?ia?aeueii? aiaee, eio?a cieaeoaaeanue
a oeae ia??iae o aiae? na. 21-I c 14011 aei 10510 (p<0,05) oa na. 1-II - ?c 19710 aei 12010 (p<0,001). Aa?oa oaaae, ui Eh-iioaioe?ae aiaee na. 21-I c?inoaa o na?aaeiueiio c +60 aei +100 iA (p<0,001), na. 1-II - ?c -50,7 aei -36,7 iA (p<0,05) o aaniyii-in?ii?e ia??iae. Ia?aeaeueii c?inoaea eiioeaio?aoe?y eenith o aiae? na. 21-I c 0,36 aei 0,49 ia/e (p<0,05). Aeiioneaeinue, ui e ?ioaineaia aenieoaoaoe?y naa?aeeiaei O?oneaaaoeueeiai ?iaeiaeua o aaniyii-in?ii?e ia??iae iineethaaea naciii? eieeaaiiy EAeA-aeoeaiino?. Aeyaeaii cai?ioi?e a?ae'?iiee ca'ycie i?ae oaeaee?noth a?aeai?o aiaee oa /enaeuei?noth noeueoao?aaeoeoth/eo i?e?ii?aai?ci?a. Eiao?oe??io ei?aeyoe?? aeey IIA na. 1-II neeaaeaa 0,70 . Oaeei /eiii, eaeoaoaeaa?ae?iaaiacia aeoeai?noue i?ia?aeueii? aiaee Iaooony a?aeaeca?eaeth? ?ioaineai?noue aeeoo?ae?yeueiino? N?I oa ?? ci?ie i?ae aieeaii i?e?iaeieo ? aio?iiiaaiieo /eiiee?a. Ia i?aenoaa? aeua aeeeaaeaiiai cai?iiiiiaaii niin?a ?aeaioeo?eaoe?? i?ia?aeueieo aiae oeio Iaooony ii ?o aeani?e oa?iaioaoeai?e aeoeaiino?. 2. Aieea aiaee Iaooony ia aaeoa??aeueio aeueoa-ai?eaco. Anoaiiaeaii /?oeo aeoeaaoe?th aaeoa??aeueii? aeueoa-ai?eace iaoeaiith IAI, a?ae 15% aei 56%, caeaaeii a?ae aiaeicaai?o. Iaeaeua aeoeaoth/a caeaoi?noue aeanoeaa aiae? na.1-II - 6,170,36 ia/nae*ie i?ioe 3,950,2 aeenoeeueiaaii? aiaee (p<0,001). Aeyaeaii caeaaei?noue nooiaiy aeoeaaoe?? a?ae oaiia?aoo?e i?ia??ao IAI ? aa?aoe??. Oae, i?ia??a IAI aei 40iN ai?iaeiaae 1 aiae c aeinooiii eenith cieaeo? aeoeai?noue aeueoa-ai?eace ia 36%, a i?aeaeuaiiy oaiia?aoo?e i?ia??ao i?eaiaeeoue aei ao?aoe aieeao ia a?inaini?. I?ia??a aiaee a aiaa?iaieo oiiaao i?e 40iN ai?iaeiaae iaei??? aiaeeie aeaiaoo?o? aeoeaoth/ee oaeoi? a iaio?e i???. Aiaeii/an, aea?ii?ciaaia aiaea oa nieueiaee aiaeia Iaooon? (NAI) - ?ic/ei, ui iiaeaeth? ?? iae?i?iiiee neeaae (I.N. ss?aiaiei e ae?., 1989), ? ?ia?oieie uiaei aeueoa-ai?eace, ye ? aeaiaoo?iaaia IAI. Ioaea, aeoeaaoe?y aeueoa-ai?eace in vitro ? niaoeeo?/iei aaeueiaiaoaeoii IAI. Iino?eiith neeaaeiaith i?aai?/iiai eiiieaeno IAI ? oaiieuei? niieoee, eio??, ye a?aeiii, noeioeththoue aeueoa-ai?eaco aaea a i?ca?ieo eiioeaio?aoe?yo - 0,001-0,000001 I. *a?ac oa a iiooeao I?-aeoeaaoi?a oa?iaioo aoee i?ioanoiaai? nae?oeeeiaa, ei?e/ia, aai?e?iiaa eeneioe o eiioeaio?aoe?yo, ni?anoaaeieo c IAI. Anoaiiaeaii, ui nae?oeeeiaa eeneioa aeoeao? aeueoa-ai?eaco a ?icaaaeaiiyo 0,00001 oa 0,000001 I ia 75% ? 57% a?aeiia?aeii. Ioaea, iiaeia aeiionoeoe, ui naia oaiieuei? niieoee, ye neeaaeia? aiaee Iaooony, ? aeoeaaoi?aie aeueoa-ai?eace. Ea?aiiia? eeneioe oaeiae ? iino?eieie neeaaeiaeie i?aai?/iiai eiiieaeno IAI, /a?ac ui aeioe?eueii aoei aeine?aeeoe ?o aieea ia aeueoa-ai?eaco. Anoaiiaeaii, ui aeeo/ai? c Iaooon? aeiaaieaioethaia? ea?aiiia? eeneioe (C16-C24) a eiioeaio?aoe?yo, ?aeaioe/ieo ai?noo NIII-a?oi a i?ia?aeuei?e aiae?: 1) aee?i? eeneioe a NAI - 70 ieI/e; 2) aee?i? eeneioe a 10 iI ?ic/ei? NaCl - 70 ieI/e, /eieee aaeuei?aio ae?th, iiae?aio a aeaio aa??aioao - ia 47% (p<0,001). Ioaea, io?eiai? aeai? aeicaieythoue aeiionoeoe, ui aeiaaieaioethaia? aee?i? eeneioe ? ?ia?a?oi?aie aaeoa??aeueii? aeueoa-ai?eace. Oaeei /eiii, nooi?iue aeoeaaoe?? aeueoa-ai?eace aiaeith Iaooony ??cieo naa?aeeiaei aecia/aany ni?aa?aeiioaiiyi aeoeaaoi??a oa ?iaea?oi??a oa?iaioo. Iaeaeuo aeoeaoth/o caeaoi?noue aiaee na. 1-II ie iiynith?ii i?enooi?noth a i?e oaiie?a ?ineeiiiai iioiaeaeaiiy a iaeneiaeueieo eiioeaio?aoe?yo aeey O?oneaaaoeueeiai ?iaeiaeua ( N.A.?aan?aea ? ?i., 1994). 3. Aieea aiaee Iaooony ia Na,K-AOOaco aioa?ioeeo?a. Aea?? Na,K-AOOace, eeth/iaiai oa?iaioa iaia?aiiiai ?iiiiai o?ainii?oo, ye a?inaini?a, coiiaeaiee aaciina?aaeiei eiioaeoii IAI ?c neeciaith oiieiai eeoa/ieea. ?ai?oa a iao?e eaai?aoi??? (I.I. Oa?eaiiaa, I.N. ss?aiaiei, 1984) a aeine?aeao in vivo aoei iieacaii, ui cieaeaiiy aeoeaiino? Na,K-AOOace aioa?ioeeo?a ia 50% niinoa??aaeinue /a?ac 30 oa i?ney aaaaeaiiy IAI uo?ai per os. Iaie anoaiiaeaii a aeine?aeao in vitro, ui aaeueioaaiiy aeoeaiino? Na,K-AOOace aioa?ioeeo?a uo?a a?aeaoaaeinue i?e aianaii? IAI a na?aaeiaeua ?ieoaaoe?? oa?iaioo a e?eueeinoyo 0,001; 0,005; 0,01; 0,1; 1,0 oa 10% a?ae ia'?io na?aaeiaeua. Aoaeo caeaaeaa a?ae aiaeicaai?o oa ia”?io IAI. Oae, aiaee na. 1-II ? na. 18-EAe iaeneiaeueii (a?aeiia?aeii, ia 47,34,9% ? 46,04,8%, p<0,001) aaeueioaaee oa?iaio o aeic? 1% ?ieoaaoe?eiiai na?aaeiaeua. Aiaea na. 21-I aaeueioaaea Na,K-AOOaco ia 41,93,6% (p<0,001), a aiaea aeaea?aea N 11 (THcy) - eeoa ia 17,92,1% o o?e aea eiioeaio?aoe??. Iaaiaee, iiaa?oiaaa (ica?ia) aiaea ia ci?ithaaea aeoeaiino? oa?iaioo (+3,60,3%). Io?eiai? aeai? na?ae/aoue i?i niaoeeo?/i?noue ae?? IAI ia o?ainii?oio Na,K-AOOaco iaia?ai aioa?ioeeo?a uo?a. Oiaoi, i?aaii??ii ia?aaeaa/aoe, ui a IAI ? niaoeeo?/i? AA?-?iaea?oi?e, eio?? ae?thoue aaciina?aaeiuei ia oa?iaio. Aiaeii/an aeyaeaii naciii? eieeaaiiy aeoeaiino? Na,K-AOOace aiaee Iaooony naa?aeeiaei O?oneaaaoeueeiai ?iaeiaeua. Oae, cieaeaiiy aaeuei?aii? ae?? aiaee na. 1-II aei -17,10,9%, a na?aaeiueiio, niinoa??aaeiny ae?oeo. A aeayeeo aeiaaeeao IAI na. 21-I oa na. 1-II e?oiueiai aiaeicaai?o aeanoeaee iaa?oue neaaeee aeoeaoth/ee aoaeo. Iaaiaee, aiaea na. 18-EAe, ui ? ia naiiaeeea?, noaa?eueii aaeueioaaea iacaaiee a?inaini?. Oaeei /eiii, nooi?iue ?iaeoeaaoe?? Na,K-AOOace aioa?ioeeo?a uo?a in vitro aecia/aany ni?aa?aeiioaiiyi ?iaea?oi??a oa aeoeaaoi??a oa?iaioo a eiiieaen? AA? aiaee Iaooony. ?o ai?no i?aeeyaaa naciiiei ci?iai ? ei?aethaaa c o?ceei-o?i?/ieie oa i?e?ia?ieia?/ieie iieacieeaie, ui na?ae/eei i?i a?iaaiia iioiaeaeaiiy aeine?aeaeoaaieo AA?. 4. Aieea aiaee Iaooony ia caaaeueio ?acenoaioi?noue i?aai?cio. Aeoeaaoe?y oaaioeeoa?ii? nenoaie . Anoaiiaeaii, ui 5-aeaiia iaiithaaiiy uo??a IAI (na.21-I) o aeic? 3,0% i.o. (ii 1,5% i.o. c ?ioa?aaeii 5 aiae) uiaeaiii caaa?ooaaeinue e?ioioeeoicii ? iiiioeeoicii e?ia? oa a?ia?ieac??th naeac?iee ca ?aooiie nooo?aiai ca?eueoaiiy /enaeueiino? e?ioi?aeieo aeaiaio?a ? oeaieiieo iae?ioaa?a. Caaaeueiee ai?no iaeo?io?e?a e?ia?, ?? oaaioeeoa?ia ?ii?noue (ai?no oaaioeeooth/eo iaeo?io?e?a) oa i?e?iaia ?ii?noue (e?euee?noue iiaeeiooeo iaeo?io?eaie i?e?ia?a) c?inoaee. Iaaiaee, oaaioeeoa?iee ?iaeaen (aeoeai?noue oaaioeeoico) caeeoaany aac ci?i, oiae? ye ?iaeaen ia?ao?aaethaaiiy (caaa?oai?noue oaaioeeoico) ciaiooaaany. Oaeei /eiii, IAI noeioeth? nenoaie ee?oeiiiai ?ioi?oaoo. I?e oeueiio, cieaeaiiy nooiaith caaa?oaiino? oaaioeeoico iiaea na?ae/eoe i?i iiaeeea?noue aaeueioaaiiy i?iaeoeoe?? eenaiuecaeaaeieo aaeoa?eoeeaeieo oaeoi??a iaeo?io?eaie o ca'yceo c aioeieneaeaioieie aeanoeainoyie aiaee. Aeoeaaoe?y nenoai caoenoo i?aai?cio a?ae enaiia?ioee?a.Ia'?eoaie aeine?aeaeaiiy aoee a?ae?ioiaia oa a?ae?io?eueia o?aeoe?? I? c e?io?e?ciaaiiai ii?ioeo aiaee oeio Iaooony na. 18-EAe( No?aeieoey). I?aia?aoe aaiaeeee uo?ai ii 1,25 ie ia?i?aeueii, ai?iaeiaae 7 aei?a. Anoaiiaeaii, ui a?ae?ioiai? I? aiaee a?aeoai?ththoue noeioethth/ee aoaeo IIA ia IIN oa ENON, oiae? ye a?ae?io?euei? I? aeoeaoththoue eeoa ENON ie?ie. Aiaeia?/i? ?acoeueoaoe io?eiai? ? i?e eo?niaiio aaaaeaii? uo?ai aeaieo i?aia?ao?a aeii/a?aaeiii (ii 0,6 ie). Ia?aeaeueii aeine?aeaeoaaee oaaioeeoa?io aeoeai?noue iaeo?io?e?a. Anoaiiaeaii, ui a?ae?ioiai? I? aiaee oeio Iaooony i?aeaeuoaaee oaaioeeoa?iee ?iaeaen (a%) c 33,53,2 (eiio?ieue) aei 47,32,8 (p<0,01), oiae? ye a?ae?io?euei? I? /eieee i?ioeeaaeio ae?th, aeaui cieaeoaaee eiai - 30,33,0 (p>0,4).

Oaeei /eiii, I? e?eoaaeueieo aiae oeio Iaooony aeoeaothoue IIN ia/?iee,
ENON ie?ie oa nenoaie ee?oeiiiai ?ioi?oaoo e?ioi?aeieo i?aai?a o e?ia?
uo??a, ui noeioeth? caaaeueio ?acenoaioi?noue i?aai?cio.

5. Ci?ie i?aai?/ieo ?a/iaei oa aaeueiaiaeoeaiino? aiaee Iaooony i?ae
aieeaii aaoiooiiieo i?e?ii?aai?ci?a. Caa??aaiiy IAI i?e oaiia?aoo??
ieanoa, a i?enooiino? eenith, /e aac iueiai, aeicaiey? aea??eiai
i?inoaaeeoe a?io?ainoi?iaoe?th i?aai?/ieo ?a/iaei ?? aa?iaieie oa
aiaa?iaieie aaoiooiiieie i?e?ii?aai?ciaie. Anoaiiaeaii, ui caa??aaiiy
IAI i?e ai?no? eenith 2 ia/e, ai?iaeiaae 30 ae?a, noi?iaiaeaeoaaeinue
ca?eueoaiiyi caaaeueii? /enaeueiino? i?e?ii?aai?ci?a a 2,3 ?. ai?iaeiaae
7 ae?a, i?ney /iai a?aeaoaaeinue iinooiiaa ciaioaiiy i?e?iaiiai /enea
aei 0,8 iei/ie ia 30 aeiao. I?e oeueiio, ??no AII o 8 ?. cao?eniaaiee ia
7 aeiao, i?ioa, iaaeae?, ?o /enaeuei?noue iinooiiai ciaiooaaeanue aei
85% aeo?aeiiai ??aiy. E?euee?noue o?iiiaieeneeo aaeoa??e ci?ithaaeanue
aiaeia?/ii, eeoa ia oae ??cei, aeinyaath/e iaeneiaeueieo cia/aiue (450
ee/ie, oiaoi 120%) ia 7 aeiao, ?c iinooiiaei ciaioaiiyi aei 300 ee/ie ia
30 aeiao caa??aaiiy. Iaaiaee, /enaeuei?noue N?I neeaaeaea eeoa 230 ee/ie
ia 7 aeiao, oa i?ney 14 ae?a caa??aaiiy aiie, ae?eni? aiaa?iae, ia
aen?aaeeny cian?i.

Aaeiaee ai?no Ni?a ciaiooaaanue ianooo?ai ai?iaeiaae 14 ae?a aa?iaiiai
caa??aaiiy IAI, a iiaeaeueoiio e?euee?noue cieceeanue ia 50% a?ae
aeo?aeiiai ??aiy aei 30 aeiae. Aiaeii/an ai?no a?ooi?a caciaa
aeano?oeoe?? (ia 90%) ai?iaeiaae 14 aei?a caa??aaiiy, oiae? ye
eiioeaio?aoe?y ai?i?a ciaiooaaeanue ??aiii??ii, i?ioa iaooeeueii,
ai?iaeiaae i?nyoey, aei 16%. ?, iaaiaee, ai?no ea?aiiiaeo eeneio
ciaiooaaanue ia 20% eeoa a ia?o? 7 ae?a, a, iio?i, aei e?ioey i?nyoey,
c?inoaa ia 30% aeua aeo?aeieo oeeo?.

Oaeei /eiii, i?inoaaeaii ?ioaineaio aeeoo?ae?yeuei?noue AII, cieaeaiiy
ai?noo a?ooi?a, iaeiie/aiiy ea?aiiiaeo eeneio i?e aa?iaiiio caa??aaii?
IAI.

Caa??aaiiy aiaee a aiaa?iaieo oiiaao noi?iaiaeaeoaaeinue ??aiii??iei oa
iaeiicia/iei ciaioaiiyi i?e?iaiiai /enea c 2,6 aei 0,5 iei/ie ai?iaeiaae
30 ae?a. I?e oeueiio, iaeneiaeueiee ??no (o 4,2 ?ace)
noeueoao?aaeoeoth/eo aaeoa??e, ye ae?enieo aiaa?ia?a, aeyaeaii ia 7
aeiao. A iiaeaeueoiio ?o /enaeuei?noue iinooiiai ciaiooaaeany, i?ioa, ua
ia 21 aeiao neeaaeaea 123% a?ae aeo?aeiiai ??aiy. Iaeneiaeueiee ??no AII
(150% a?ae aeo?aeiiai ??aiy) niinoa??aaee ia 3 aeiao, c iinooiiaei
ciaioaiiyi ?o /enaeueiino? aei 88% /a?ac 30 ae?a caa??aaiiy. Iaaiaee,
/enaeuei?noue o?iiiaeo aaeoa??e, ye ae?enieo aa?ia?a, i?ney iacia/iiai
?inoo (11%) ia 3 aeiao, iaooeeueii ciaiooaaeany, aeinyaath/e 30,9% a?ae
aeo?aeiiai ??aiy ia 17 aeiao caa??aaiiy.

Anoaiiaeaii iinooiiaa i?aeaeuaiiy ai?noo Ni?a i?e caa??aaii? IAI a
aiaa?iaieo oiiaao. Oae, ai?no Ni?a aeinyaaa iaeneioio (121% i?e?inoo) ia
24 aeiao caa??aaiiy ? caeeoaany ia 18% aeua aeo?aeiiai ??aiy ia 30
aeiao.Ai?no a?ooi?a iinooiiai ciaiooaaany ia 10% a?ae aeo?aeiiai ??aiy.
I?ioa aeyaeaii iaeiini?yiiaaia ca?eueoaiiy ai?i?a (o 2 ?ace) oa
ea?aiiiaeo eeneio (o 1,5 ?ace.) ia 30 aeiao caa??aaiiy.

Aiae?coth/e ci?ie i?aai?/ieo ?a/iaei oa aaoiooiiieo i?e?ii?aai?ci?a
i?e aa?iaiiio ? aiaa?iaiiio caa??aaii? IAI, eiinoaoiaaii ??cea ciaioaiiy
a?ooi?iicieo niieoe (ia 45%) c iaeii/aniei ca?eueoaiiyi /enaeueiino? AII
o 8 ?ac ia 7 aeiao aa?iaiiai caa??aaiiy.I?ioa i?e aaceeniaaiio
caa??aaii? anoaiiaeaii ??no ea?aiiiaeo eeneio (ia 203, 6%), iacia/io
aeano?oeoe?th a?ooi?a oa ca?eueoaiiy AII ia 150% a oeae ia??iae.
Eiinoaoiaaii a?iaaiia iaa?iiaaeaeaiiy ea?aiiiaeo eeneio, ai?i?a oa
Ni?a.

Oaeei /eiii, i?ia?aeia ?ieue o aeano?oeoe?? a?ooi?iicieo niieoe oa
iaa?iiaaeaeaii? aiaei?ic/eiieo I? (ea?aiiiaeo eeneio) iaeaaeeoue
aaoiooiiiei AII aiaee Iaooony. Cie?aia, ?ioaineai?noue anei?eyoe??
a?ae?ioiaieo I? a aa?iaieo oiiaao o 5 ?ac?a aeua, i?ae a oiiaao aac
aeinooio eenith.

Anoaiiaeaii, ui aaeueiaieia?/ia aeoeai?noue IAI ii caeaoiino?
aaeueioaaoe Na,K-AOOaco aioa?ioeeo?a uo?a oaeiae ci?ithaaeinue a
i?ioean? caa??aaiiy. Oae, IAI caa??aaea aaeueioth/o caeaoi?noue
ai?iaeiaae 14 ae?a i?e a?aenooiino? eenith. Iaaiaee, iaoeaia ? iane/aia
eeniai (17 ia/e) IAI ao?a/aea ?ia?aoth/o caeaoi?noue aaea /a?ac 24 aiae
caa??aaiiy, oiae? ye aa?iaaia aaci?e?iaia IAI — /a?ac 3 aeiae. A
ianooii? aei? i?iyaeyee ae?th aeoeaaoi?e Na,K-AOOace, iaeneioiaeueii
noeioethaaee oa?iaio ia 7 aeiao (107%). I?ioa, aaea ia 10 aeiao
e?euee?noue aeoeaaoi??a oaeaeei ciaiooaaeanue. Aiaea,eio?a i?noeoue 2
ia/e eenith, ao?a/aea aaeuei?aiee aieea ia oa?iaio aeaui i?ci?oa (ia 3
aeiao) oa i?iyaeyea cia/ii neaaoee aeoeaoth/ee aoaeo (50%) ia 7 aeiao
caa??aaiiy. Iiae?ai? ?acoeueoaoe io?eiai? i?e oanooaaii? aa?iaaii? aiaee
ia ?cieueiaaieo i?aia?aoao AI oa na?oey oa ia i?ioeane eeneioiooai?aiiy
a oeoieo niaae (I.N. ss?aiaiei e ae?., 1989).

Oaeei /eiii, a?io?ainoi?iaoe?y AA? IAI aaoiooiiieie i?e?ii?aai?ciaie
no?iai caeaaeaea a?ae e?eueeino? ?ic/eiaiiai o aiae? eenith. Iieacaii,
ui ?iaea?oi?e ?ii-o?ainii?oii? AOOace oa AI ia?aaaaeaee o aiae? Iaooony
i?e a?aenooiino? eenith, ?, iaaiaee, ?o aeoeaaoi?e aeii?ioaaee a
aa?iaieo oiiaao. Noia?iee aoaeo IAI aecia/aany e?euee?niei
ni?aa?aeiioaiiyi ?iaea?oi??a oa aeoeaaoi??a, ui caeaaeaei a?ae
?ioaineaiino? canai?iiy a?ooi?iicieo niieoe ?? AII. Anoaiiaeaii, ui IAI
ao?a/aea aaeueiaiaeoeai?noue ia 10-20 aeiao caa??aaiiy a aa?iaieo
oiiaao.

Aeyniaiiy o?i?/ii? i?e?iaee aeyaeaieo AA? oa ?ie? ie?aieo a?oi
i?e?ii?aai?ci?a o ?o aaiac? noaei caaaeaiiyi ianooiieo aeine?aeaeaiue.

6. Iiaeaethaaiiy aaiaco aee?ieo eeneio oa aeine?aeaeaiiy ?o ?ie? a
aaeueiaiaeoeaiino? aiaee Iaooony. Anoaiiaeaii, ui /ioe?ueiooeaeiaaa
?ieoaaoe?y aaoiooiiieo i?e?ii?aai?ci?a IAI c eiia?oe?eiei iciea?eoii
noi?iaiaeaeoaaeanue ooai?aiiyi aiaei?ic/eiieo AA? (?aan?aea N.A., 1994),
i?e?iaea eio?eo caeeoa?oueny iaa?aeiiith. Ea?oth/enue e?oa?aoo?ieie
aeaieie, ui aee?i? eeneioe ? iino?eieie neeaaeiaeie IAI o eiioeaio?aoe??
0,01-0,1 iIieue/e (A.I. ssnaae/, 1982; A.N. Aaaoiiaa, 1986) oa
?acoeueoaoaie aeanieo aeine?aeaeaiue, ui AII caaacia/othoue aea??eiaa
iaeiie/aiiy AEE i?e aa?iaiiio caa??aaii? IAI, aaaaeaee ca aeioe?eueia
aeine?aeeoe iiaeeea?noue ooai?aiiy AEE oeyoii i?e?iaii?
a?io?ainoi?iaoe?? aoaeaaiaeiaai? ne?iaeie: aiaeiai?nii? ii?iaee
O?oneaaaoeueeiai ?iaeiaeua Iaooon?, ai?eneaanueeiai iciea?eoo, iaooe,
ia?ao?iiaiai ianea.

Iaoiaeii aaeue-o?iiaoia?ao?? c?aeaioeo?eiaaii 7 aiaei?ic/eiieo niieoe
AII-iaoaaie?o?a, 4 c eio?eo ?aeaioe/i? a?ae?io?eueiei I? IAI.

Anoaiiaeaii, ui eoeueoo?aeueia ??aeeia (E?) caeaoia aaeueioaaoe
Na,K-AOOaco a ?icaaaeaii? 1-0,01% aei ia’?io ?ieoaaoe?eiiai na?aaeiaeua
ia 6-12 aeiao eoeueoeaoaaiiy AII. Aeacaiee aoaeo ia caeaaeaa a?ae
aeei?enoaii? aoaeaaiaeiaai? ne?iaeie. Aiaeii/an, aaeuei?aia caeaoi?noue
E? /?oei ei?aethaaea ?c ai?noii AEE a i?e, /a?ac oea i?aaii??ii
aeiionoeoe, ui naia AEE ? ?iaea?oi?aie Na,K-AOOace. Aeey
i?aeoaa?aeaeaiiy oeueiai aeiiouaiiy i?iaaaeaii na??th aenia?eiaio?a c
aeine?aeaeaiiy ae?? AEE, aeae?eaieo c aiaee Iaooony oa eoeueoo?aeueii?
??aeeie. Iieacaii, ui AEE aiaee Iaooony (N16-N24) ? E? (N9-N18), a aeic?
0,1 ieIieue/e, a??ia?aeii aaeueioaaee aeoeai?noue oa?iaioa, a
na?aaeiueiio, ia 26,51,5% (p<0,05) ? 32,83,1% (p<0,01), a?aeiia?aeii. Aei?a/ii aeiaeaoe, ui aoaeoeai?noue aaeueioaaiiy AEE aeacaiiai oa?iaioa ??aiicia/ia ?icaaaeaiiyi iaoeaii? IAI. Oaeei /eiii, io?eiai? aeai? aeicaieythoue noaa?aeaeoaaoe, ui AEE aiaee Iaooony ooai?ththoueny a ?acoeueoao? a?io?ainoi?iaoe?? aoaeaaiaei?a iaooiaiai iioiaeaeaiiy aaoiooiiieie AII ? ? oeie AA?, ui coiiaeththoue aaeueioaaiiy Na,K-AOOace. A aeine?aeao in vivo anoaiiaeaii, ui AII-iaoaaie?oe iciea?eoo caeaoi? aeoeaoaaoe nenoaie caoenoo i?aai?cio a?ae enaiia?ioee?a. Ia'?eoaie aeine?aeaeaiy aoee a?ae?ioiaia oa a?ae?io?eueia o?aeoe?? e?io?e?caoo E?. I?aia?aoe aaiaeeee uo?ai uiaeaiii, ii 1,25 ie ia?i?aeueii, aai ii 0,6 ie aeii/a?aaeiii, ai?iaeiaae 7 aei?a. Aeyaeaii, ui iacaeaaeii a?ae niiniao aaaaeaiiy, a?ae?ioiai? iaoaaie?oe noeioethaaee IIN ia/?iee oa ENON ie?ie, a oaeiae i?aeaeuoaaee oaaioeeoa?iee ?iaeaen iaeo?io?e?a (o %) c 33,53,2 (eiio?ieue) aei 41,03,9 (p<0,05), oiae? ye aiaei?ic/eii? I? caeiiii??ii noeioethaaee ENON ie?ie, i?ioa a??ia?aeii cieaeoaaee oaaioeeoa?iee ?iaeaen iaeo?io?e?a (o %) - aei 25,03,0 (p<0,05). Oaeei /eiii, i?iaeoeoe a?io?ainoi?iaoe?? aoaeaaiaeiaai? ne?iaeie aaoiooiiieie i?e?ii?aai?ciaie aiaee Iaooony a?aeoai?thaaee aaeueiaiaeoeai?noue iaoeaii? i?ia?aeueii? aiaee i?e aaaaoi?aciaiio iaaeoiaeaeaii? a i?aai?ci. AENIIAEE 1. Eaeoaoaeaa?ae?iaaiacia aeoeai?noue ? a?ieia?/iei ?iaeeeaoi?ii aiae oeio Iaooony ? /?oei ei?aeth? c /enaeuei?noth aaoiooiiieo noeueoao?aaeoeoth/eo i?e?ii?aai?ci?a. Iaeaeua ieoiia aeoeai?noue aaeoa??aeueii? eaeoaoaeaa?ae?iaaiace i?eoaiaiia aiaa?iaiei aaeoa??yi- Desulfovibrio desulfuricans. 2. Aaeueiaiaeoeai? i?aai?/i? ?a/iaeie aiaee Iaooony aieeaathoue ia aeoeai?noue oa?iaio?a oiieiai eeoa/ieea (?iaeoeothoue aeueoa-ai?eaco oa ?ia?aothoue ?iio?ainii?oi? AOOace iaia?ai aioa?ioeeo?a). Aeacai? a?inaini?e cai?iiiiiaaii aeei?enoiaoaaoe aeey aea/aiiy a?ieia?/ii? aeoeaiino? i?ia?aeueieo aiae oeio Iaooony oa ?ioeo i?ia?aeueieo aiae oa e?ea?nueeeo cania?a. 3. I?ia?aeueia aiaea Iaooony noeioeth? ?ioiiaaiac ca ?aooiie i?aeaeuaiiy ??aiy i?e?i- oa iae?ioaa?a, oaaioeeoa?ii? oa i?e?iaii? ?iiino? e?ia?, a oaeiae ca?eueoaiiy ai?noo e?ioi?aeieo aeaiaio?a o naeac?ioe? i?e aaaaoi?aciaiio iinooieaii? a i?aai?ci. Iioaioe?eieie aeoeaaoi?aie ?ioiiaaiaco ? a?ae?ioiai? i?aai?/i? niieoee aiaee Iaooony, eio?? i?aeaeuothoue oaaioeeoa?io aeoeai?noue iaeo?io?e?a, oiae? ye a?ae?io?euei? ?a/iaeie aeaui cieaeothoue ??. 4. ?ic?iaeai? a?inaini?i? iaoiaee i?iiiio?ii aeei?enoiaoaaoe aeey ei?aeoiiai oa oaeaeeiai iii?oi??iao ci?i aaeueiaiaeoeaiino? i?aai?/ieo eiiiiiaio?a i?ia?aeueieo aiae oeio Iaooony, coiiaeaieo aio?iiiaaiieie oa i?e?iaeieie /eiieeaie.Aiie aeicaieythoue aeooaeueii canoinoaaoe caoiaee aeieia?/ii? aaciaee ?iaeiaeua. 5. Aoaeaaiaeaiueieenethth/? oa noeueoao?aaeoeoth/? i?e?ii?aai?cie ? i?iaeooeaioaie aiaei?ic/eiieo a?ieia?/ii aeoeaieo ?a/iaei i?ia?aeueii? aiaee Iaooony. I?e oeueiio, aoaeaaiaeaiueieenethth/? i?e?iae caaacia/othoue aea??eiaa iaeiie/aiiy aee?ieo eeneio i?e eoeueoeaoaaii? c aoaeaaiaeiaaith ne?iaeiith iaooiaiai iioiaeaeaiiy, a oaeiae i?e aa?iaiiio caa??aaii? i?ia?aeueii? aiaee. 6. AEe?i? eeneioe aiaee Iaooony ? ?iaea?oi?aie Na,K-AOOace. AEe?i? eeneioe, io?eiai? oeyoii i?e?iaii? a?io?ainoi?iaoe?? aoaeaaiaeiaai? ne?iaeie, a?aeoai?ththoue aaeuei?aiee aieea iaoeaii? i?ia?aeueii? aiaee ia iaia?aiiee ?ii-o?ainii?iee oa?iaio. 7. I?iaeoeoe a?io?ainoi?iaoe?? iciea?eoo anioe?eiaaiith eoeueoo?ith aoaeaaiaeaiueieenethth/eo i?e?ii?aai?ci?a a?aeoai?ththoue aieea aiaee Iaooony ia nenoaie caoenoo i?aai?cio a?ae enaiia?ioee?a. I?e oeueiio, a?ae?ioiai? i?aai?/i? niieoee eoeueoo?aeueii? ??aeeie, ye ? aiaee Iaooony, noeioeththoue i?e?iniiaeueio iiiiieneaaiacio nenoaio ia/?iee, eaiaeueoeaao nae?aoi?ii-o?ainii?oio nenoaio ie?ie ? i?aeaeuothoue oaaioeeoa?io aeoeai?noue iaeo?io?e?a, oiae? ye a?ae?io?euei? iaoaaie?oe caeiiii??ii aeoeaothoue nae?aoi?ii-o?ainii?oio nenoaio ie?ie ? cieaeothoue oaaioeeoa?io aeoeai?noue iaeo?io?e?a. Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe??: 1. ss?aiaiei I.N., Eaaneaea N.A., Iiiiae/ E.E., Aeean A.?., ssnaae/ A.I., Caai?iaeithe A.I., Noaoeaiei A.E., Aoooniaa E.A., I?ieiiaiei I.I., Oa?eaiiaa I.I., Eaoei I.A., Aaaa A.ss. Oeceieiae/aneea iniiau ea/aaiiai aeaenoaey aiaeu Iaooony.- E.: Iaoeiaa aeoiea, 1989.- 144 n. 2. ss?aiaiei I.N., Aeean A.?., Iauae A.A. Oa?ie/aneay onoie/eainoue aooiooiiiie, iee?ioei?u ieia?aeueiie aiaeu Iaooony // Aii?. eo?i?oie.- 1987.- N 7.- N. 46-49. 3. ss?aiaiei I.N., Caai?iaeithe A.I., Aeean A.?., Aaaa A.ss., Oa?eaiiaa I.I. Ioeaiea aeieiae/aneie aeoeaiinoe ieia?aeueiie aiaeu Iaooony // Oeceie. aeo?i.- 1988.- 34, N 6.- N. 80-85. 4. Aeean A.?. Naciiiua eciaiaiey iee?ioei?u e oeceei-oeie/aneeo oa?aeoa?enoee ieia?aeueiie aiaeu Iaooony eo?i?oa O?oneaaaoe //Eo?i?oieiaey e oeceioa?aiey.- Aui. 21.- E. Caei?ia'y, 1988.- N. 16-18 5. ss?aiaiei I.N., Aeean A.?., Caai?iaeithe A.I. Enneaaeiaaiea aaiaca e ?iee aee?iuo eeneio eae aeieiae/anee aeoeaiuo eiiiiiaioia ieia?aeueiie aiaeu Iaooony // Aii?. eo?i?oie.- 1989.- N 5.- N. 62-65. 6. Iiiiae/ ?.E., ?aan?aea N.A., Aenaio?e/oe A.?., Eiaaanithe I.I., A?ean A.?. Aeoeaaoe?y i?aai?/ieie ?a/iaeiaie e?eoaaeueieo aiae oeio "Iaooony" nenoai caoenoo i?aai?cio a?ae /oaea??aeieo aaaio?a // Iaaee/ia ?aaa?e?oaoe?y, eo?i?oieia?y, o?c?ioa?ai?y.- 1996.- N 3(7).- N. 30-36. 7. Eiaaeue/oe A.ss., ?aan?aea N.A., Iiiiae/ ?.E., A?ean A.?.. Aieea aiaee Iaooony ia i?ioean e?iiia?ieneaeaoe?? oa ?ioi?oao o uo??a //I?iaeaie iaoieia?? a aenia?eiaio? ? ee?i?oe?.O.17.-Euea?a, - 1996.- N.181-184. 8. A?ean A.?. Aaeueiaioaoiieia?/ia iiaeaethaaiiy caaaa/aiiy aiaee "Iaooony" aaeueiaiaeoeaieie eiiiiiaioaie // I?iaeaie iaoieia?? a aenia?eiaio? ? ee?i?oe?.O.17.-Euea?a, - 1996.- N.194-198. 9. Aaee/ei E.I., Ae?en??a I.?., Iiiiae/ ?.E., Na?ai/a N.I., A?ean A.?. *e a?aeia?aaeo? eaeeia?aia e?ia? noai ii??iino? i?aai?cio? // Caeiaooee ee?i?/ii? oa aenia?eiaioaeueii? iaaeeoeeie.- Iaoa?. 40-? i?aenoieiai? iaoe. eiio.- Aei.2, /.1.- Oa?iii?eue, 1997.- N. 60-62. 10. ssnaae/ A.I., Aeean A.?. Eciaiaiea i?aaie/aneeo aauanoa aiaeu Iaooony iiae aeeyieai ay?iaiie e aiay?iaiie iee?ioei?u // Oac. aeiee. XXIX Ananithci. niaau., iinayu. ninoiyieth e ia?niaeoeaai ?acaeoey iaoiaeieiae/aneeo iniia oeie/aneiai e aeieiae/aneiai iiieoi?eiaa iiaa?oiinoiuo aiae nooe (?inoia-ia-Aeiio, ieoya?ue, 1987 a.).- O.1.- ?inoia-ia-Aeiio, 1987.- N. 337-338. 11. ss?aiaiei I.N., ssnaae/ A.I., Aeean A.?. Aeeyiea ?aaeeia yenieoaoaoeee ia ninoaa e naienoaa aiaeu Iaooony // Aeae?iaaieiae/aneea aniaeou oi?ie?iaaiey e io?aiu ieia?aeueiuo aiae Oe?aeiu: Oac. aeiee. Ananithci. eiio. Eino. aaieiaee AI ONN? (Eeaa, ethiue, 1988).- E., 1988.-N. 30-31. 12. Aeean A.?., Caai?iaeithe A.I. Aeeyiea eioaineaiinoe ioai?a aiaeu Iaooony ia aa aeieiae/aneoth aeoeaiinoue // Iooe oiaiueoaiey aio?iiiaaiiiai aicaeaenoaey ia i?e?iaeiua eo?i?oiua ?ano?nu: Oac.aeie. ?ani. iao/.-i?aeo. eiio. (Iaeanna, 8-12 ieoya?y 1990 a.)- Iaeanna,1990.- N. 41-42. 13. ?aan?aea N.A., ssnaae/ A.I., Aaaaeye I.A., A?ean A.?., Aa?a ?.ss., Iiiiae/ ?.E., Eiaaaithe I.I., Iaaeee A.?., Oieianueea Ae.I. Neeaae oa aeanoeaino? i?ia?aeueii? aiaee "Aooa" // Aeooaeueiua aii?inu naiaoi?ii-eo?i?oiiai ea/aiey.- Iaoa?. iao/.-i?aeo. eiio.- Oaeai?iae, 1990.- N. 37-39. 14. ?aan?aea N.A., A?ean A.?. Aaiac a?ae?io?eueieo i?aai?/ieo niieoe aiaee "Iaooony" // Eo?i?oiua oaeoi?u I?eea?iaouey a iaaeeoeeineie e nioeeaeueiie ?aaaeeeoaoeee aieueiuo aea?iaoicaie: Iao. 2-e ?ani. iao/.-i?aeo. eiio. aea?iaoieiaia e eo?i?oieiaia.- Eueaia, 1991.-N. 23-24. 15. Noaoeaiei A.?., Aenaio?e/oe A.?., Aaeaea I.A., Eaeieeia E.C., A?ean A.?., Eiaaeuenueeee N.A., Nia'ye N.ss. ?aae?aoe?eia iaaaioaaeaiiy o ae?oae, iioa?i?eeo a?ae *i?iiaeeuenueei? eaoano?ioe, ye? icaei?iaeththoueny ia eo?i?o? O?oneaaaoeue // Iia? i?aeoiaee aei i?aai?caoe?? ? i?iaaaeaiiy e?eoaaiiy ?aaa?e?oaoe?? oa ?ae?aaoe?? a oiiaao eo?i?oo: Iaoa?. iaoe.-i?aeo. eiio.- O?oneaaaoeue, 1995.- N. 48-50. 16. Na?ai/a N.I., Iaianthe A.I., Iiiiae/ ?.E., A?aa?ithe I.A., Neaio?i ?.N., Aeaienia N.A., ssaaeuenueea A.N., Iaca?aiei I.E., A?ean A.?. ?ioiiee noaoon oeiey??a , i?iaeeaath/eo ia ?aae?aoe?eii eiio?ieueiaaieo oa?eoi??yo, ? aieea ia iueiai e?eoaaeueieo oaeoi??a eo?i?oo O?oneaaaoeue // Iaaee/ia ?aaa?e?oaoe?y iioa?i?eeo aiane?aeie *i?iiaeeuenueei? eaoano?ioe: Oac. aeii. iaoe.-i?aeo. eiio.- O?oneaaaoeue, 1996.-N. 56-57. 17. Ae?en??a I.?., Iaianthe ?.I., Iiiiae/ ?.E., Aa?eeye E.A., A?ean A.?., Aa?a ?.ss. Aenia?eiaioaeueia ? ee?i?ei-o?c?ieia?/ia iaa?oiooaaiiy canoinoaaiiy aaeuecaio "E?einueeee" aeey i?aeaeuaiiy aoaeoeaiino? ?aaa?e?oaoe?? ia eo?i?o? O?oneaaaoeue iioa?i?eeo a?ae *i?iiaeeuenueei? eaoano?ioe // Iaaee/ia ?aaa?e?oaoe?y iioa?i?eeo aiane?aeie *i?iiaeeuenueei? eaoano?ioe: Oac. aeii. iaoe.-i?aeo. eiio.- O?oneaaaoeue, 1996.- N. 75-77. 18. A?ean A.?., Ea?ia A.A. I?aai?/i? eiiiiiaioe aiaee "Iaooony" - iiaeoeyoi?e oa?iaio?a oiieiai eeoe?aieea (aeueoa-ai?eace oa Na,K-AOOace) // 7-ee Oe?. a?io?i. c”?cae. Oace aeii.,/.3.- Ee?a, 1997.- N.5. AIIOAOe?ss A?ean A.?. Aaeueiaiaeoeai?noue i?aai?/ieo ?a/iaei aiaee "Iaooony" oa i?aeoiaee aei iiaeaethaaiiy ?o iioiaeaeaiiy.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.33- eo?i?oieia?y oa o?c?ioa?ai?y.- I?i?noa?noai ioi?iie caei?ia”y Oe?a?ie, Oe?a?inueeee IAe? iaaee/ii? ?aaa?e?oaoe?? oa eo?i?oieia?? , Iaeana,1998. Aeena?oaoe?th i?enay/aii aeine?aeaeaiith i?iya?a aaeueiaiaeoeaiino? ie?aieo a?oi i?aai?/ieo ?a/iaei e?eoaaeueii? aiaee "Iaooony" ? aeyniaiith ?o iioiaeaeaiiy. Aeyaeaii iia? aoaeoe "Iaooon?" in vitro oa in vivo, /ei ?icoe?aii iaa?? oano?a aeey ioe?iee ?? aaeueiaiaeoeaiino?. Aia?oa i?iaeaiiino?iaaia iiaeeea?noue io?eioaaoe aaeueiaiaeoeai? /eiieee "Iaooon?" iaoiaeii i?e?iaii? a?ioaoiieia?? ?c ??ciiiai?oii? aoaeaaiaeiaai? ne?iaeie (iciea?eoo, iaooe, ia?ao?io). ?ic?iaee ai?iaaaeaeai? a i?aeoeeo O?oneaaaoeueei? a?ae?iaaieia?/ii? ?aaeeiii-aenieoaoaoe?eii? noaioe?? oa eaai?aoi??? aenia?eiaioaeueii? aaeueiaieia?? ? aeei?enoiaothoueny aeey iii?oi?eiao aaeueiaiaeoeaiino? ?iaeiaeua, ioe?iee iaoiae?a i/euaiiy aiaee a?ae aeeiooiiii? i?e?ioei?e, ?aeaioeo?eaoe?? aiae iiaia?aee?eoeo ?iaeiaeu oa naa?aeeiaei ia i?aaeiao i?eiaeaaeiino? aei oeio "Iaooony". Eeth/ia? neiaa: aiaea "Iaooony", i?aai?/i? ?a/iaeie, aaoiooiiia i?e?ioei?a, i?e?iaia a?ioaoiieia?y, aaeueiaiaeoeai?noue. AIIIOAOeEss Aeean A.?. Aaeueiaiaeoeaiinoue i?aaie/aneeo aauanoa aiaeu "Iaooony" e iiaeoiaee e iiaeaee?iaaieth eo i?ienoiaeaeaiey.- ?oeiienue. Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.33.- eo?i?oieiaey e oeceioa?aiey.- Ieienoa?noai cae?aaiio?aiaiey Oe?aeie, Oe?aeineee IAeE iaaeeoeeineie ?aaaeeeoaoeee e eo?i?oieiaee, Iaeanna,1998. Aeenna?oaoeey iinayuaia enneaaeiaaieth i?iyaeaiee aaeueiaiaeoeaiinoe ioaeaeueiuo a?oii i?aaie/aneeo aauanoa ea/aaiie aiaeu "Iaooony" e auyniaieth eo i?ienoiaeaeaiey. Auyaeaiu iiaua yooaeou "Iaooone" in vitro e in vivo, /ai ?anoe?ai iaai? oanoia aeey ioeaiee aa aaeueiaiaeoeaiinoe. Aia?aua i?iaeaiiino?e?iaaia aiciiaeiinoue iieo/aoue aaeueiaiaeoeaiua ia/aea "Iaooone" iaoiaeii iee?iaiie aeioaoiieiaee ec ?acee/iiai oaeaaiaei?iaeiiai nu?uey (iciea?eoa, iaooe, ia?aoeia). ?ac?aaioee iaoee aiaae?aiea a i?aeoeeo O?oneaaaoeeie aeae?iaaieiae/aneie ?aaeeiii-yenieoaoaoeeii-iie noaioeee e eaai?aoi?ee yenia?eiaioaeueiie aaeueiaieiaee i?e iiieoi?eiaa aaeueiaiaeoeaiinoe ianoi?iaeaeaiey, ioeaiea iaoiaeia i/enoee "Iaooone" io aeeiooiiiie iee?ioei?u, eaeaioeoeeaoeee aiae oeia "Iaooony" iiauo ianoi?iaeaeaiee e neaaaeei. Eeth/aaua neiaa: aiaea "Iaooony", i?aaie/aneea aauanoaa, aaoiooiiiay iee?ioei?a, iee?iaiay aeioaoiieiaey, aaeueiaiaeoeaiinoue. SUMMARY Bilas V.R. The balneoactivity of the organic substances of the water "Naftussya"and modulation of their genesis.- The manuscript. The thesis for the obtaining the Candidates Degree in Medical Science on the specialty 14.01.33 - balneology and physiotherapy. Ukrainian research institute medical reabilitation and balneology.Idessa, 1998. The thesis is dedicated to the analysis of the manifestation of balneoactivity of the separate groups of organic substance of the security water "Naftussya" and the elucidation of their genesis. It is elucidated the new effects of "Naftussya" in vitro and in vivo and that is why it is increased the set of the tests for the valuation its balneoactivity. For the first time the possibility to get the balneoactive components of "Naftussya" with the method of the microbial biotechnology from different hydrocarbonic substances (oil, ozokerite, paraffin) is demonstrated. The elaborations are put into the practice Truskavets hydrogeological a exploratory station and the laboratory of the experimental balneology and they are used for the monitoring of the balneoactivity of the deposit, the valuation of the methods of the waters purification from allokhtonic microflora, the identification of the water in the new deposits ("Naftussya"-fieds) and the pors as the object to discover the thype of the water like "Naftussya". Key words: water "Naftussya", organic substances, autochtonicmicroflora, microbic biotechnology, balneoactivity.

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