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Антигіпертензивна ефективність антагоністів кальцію дигідропіридинового ряду пролонгованої дії у співставленні зі станом клітинної мембрани еритроциті

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AEAAeAI?ss IAAeE*IEO IAOE OE?A?IE

?INOEOOO EA?Ae?IEIA?? ?i. aeaae. I. Ae. NO?AAEANEA

NAIEEIIIA OAOssIA A?EOI??AIA

OAeE: 616.12.-008.331.1:615.22

AIOEA?IA?OAICEAIA AOAEOEAI?NOUe AIOAAII?NO?A EAEUeOe?TH
AeEA?Ae?II??EAeEIIAIAI ?ssAeO I?IEIIAIAAII? Ae?? O NI?ANOAAEAII? C?
NOAIII EE?OEIII? IAIA?AIE A?EO?IOeEO?A OA NO – NENOAIE

14.01.11 – EA?Ae?IEIA?ss

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

EE?A – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea

AII Oe?a?ie.

Iaoeia? ea??aieee:

aeieoi? iaaee/ieo iaoe I?o/aiei Ieaia ?aai?aia, ?inoeooo ea?ae?ieia??
?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie, i?ia?aeiee iaoeiaee ni?a?ia?oiee
a?aeae?eaiiy ee?i?/ii? oa?iaeieia??;

aeieoi? a?ieia?/ieo iaoe, /eai-ei?aniiiaeaio IAI oa AII Oe?a?ie Aoea
Iaae?y Iaenei?aia, ?inoeooo a?io?i?? ?i. I.A. Iaeeaae?ia IAI Oe?a?ie,
caa?aeoaa/ a?aeae?eii a?io?i?? e?i?ae?a.

Io?oe?ei? iiiiaioe:

aeaaeai?e IAI Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani? Iieaaiei Ieaen?e
Ieaen?eiae/, caa?aeoaa/ a?aeae?eii aenia?eiaioaeueii? ea?ae?ieia??
?inoeoooo o?c?ieia?? ?i. I.I.Aiaiiieueoey IAI Oe?a?ie;

aeieoi? iaaee/ieo iaoe, i?ioani? N??aiei TH??e Ieeieaeiae/, caa?aeoaa/
a?aeae?eaiiy neiioiiaoe/ii? a?ia?oaic?? c eaai?aoi???th
aeno?aei?ii?aeueieo iaoiae?a e?eoaaiiy ?inoeoooo ea?ae?ieia?? ?i. aeaae.
I.Ae.No?aaeanea AII Oe?a?ie.

I?ia?aeia onoaiiaa:

Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y IIC Oe?a?ie, eaoaae?a
aini?oaeueii? oa?ai?? ?2.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “12” aeiaoiy 1999 ?. i 12 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.616.01 i?e ?inoeooo?
ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie, (252151, i. Ee?a,
aoe. Ia?iaeiiai iiie/aiiy, 5).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo
ea?ae?ieia?? ?i. aeaae. I.Ae.No?aaeanea AII Oe?a?ie, (252151, i. Ee?a,
aoe. Ia?iaeiiai iiie/aiiy, 5).

Aaoi?aoa?ao ?ic?neaiee “ 9 ” aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee
Aeaye N.?.

CAAAEUeIA OA?AEOA?ENOEEA

Aeooaeueiinoue oaie. Anaioeiaeueia a?oa??aeueia aiia?oaiciy (AA) – iaeia
c iaeaieueo iioe?aieo caoai?thaaiue na?oeaai-noaeeiii? nenoaie
caeeoa?oueny neeaaeiith no/aniith iaaeeei-aiieiai/iith i?iaeaiith. A
15-25% aei?ineiai ianaeaiiy aieueoinoi e?a?i naioo a?aei?/aii
iiaeaeuaiiy a?oa?iaeueiiai oeneo (AO) (Naeuaiei A.I.,1997; Aeieeaae
eiieoaoa yenia?oia AIIC, 1997), yeee ? ?acoeueoaoii neeaaeii? aca?iiaei?
iae?iaaiieo, aiaeie?eiieo, iaoaaiei/ieo oa iioeo /eiieeia. Na?aae ieo
aaaeeeaa iinoea iiniaea? iiooaeiee aii?aaoeyoi? – ieneae acioo (NO). I?e
AA iecea iaoiaaiaoe/ieo aniaeo?a iia’ycaia c aeenooieoe??th NO-nenoaie
(Furchgott R., Zawadzki J., 1980; Lusher T.F. et al.,1993). Aaeueioaaiiy
neioaco NO aai iiaeaeuaia eiai iiaeoeaaoeiy iiaea aieeaaoe ia c?inoaiiy
ia?eoa?ieiiai noaeeiiiai oiiono ? oi?ioaaiiy AA (Loscalzo J., 1995).
E??i oiai, aeneiaeaii a?iioaco, ui iniiaith ia?aeiieo oi?i a?ia?oaic?? ?
aaiaoe/ii aeaoa?i?iiaai? a?aeoeeaiiy a eii-o?ainii?oi?e ooieoe??
ieaciaoe/ii? iaia?aie ee?oei, iia’ycai? c oe?eei niaeo?ii ci?i ??
no?oeoo?e oa ooieoe?? (Iinoiia TH.A., 1993). E?i?aee ae ? eeth/iaeie
neeaaeieeaie ieaciaoe/ieo iaia?ai, oiio ii?ooaiiy ?o aee?ii-eeneioiiai
neeaaeo i?ecaiaeeoue aei ci?i ?aaoeyoe?? noaeeiiiai oiiono (Iieaaiei
I.I. oa ?i., 1995; Oeoia A.I., 1998; Tadde S. et al., 1998).

Aaaeeeaeie no/anieie aaciaeeeaooth/eie caniaaie aeey e?eoaaiiy AA ?
aioaaii?noe eaeueoe??aeo eaiae?a (AE) (Melchiorre ?., Gianutlla M.,
1988). Caoaaaeeii, ui aeey ei?ioeiae?th/eo AE aeea?ae?ii??eaeeiiaiai
?yaeo a?aei?/aii iani?eyoeeaa i?iaiinoe/ia cia/aiiy i?e o?eaaeiio
aeei?enoaii? (Alderman M. et al. 1997), ui ni?eyei ?ic?iaoe?
i?ieiiaiaaieo oi?i AE. A inoaii? ?iee ii?eethaeiaii a?aeiiino?, ui AE
ni?e/eiythoue iiaeaeuaiiy ?iaiy NO a oee?eoethth/ie e?iai, a iniia? /iai
iiaeooue eaaeaoue aeaa iaoai?cie: ia?oee noino?oueny ae?? aioaaii?no?a
eaeueoe?th ye iiooaeieo aioeieneaeaio?a, aiane?aeie /iai ciaioo?oueny
ia?aeenia aeano?oeoe?y NO. A iniia? ae?oaiai iaoai?cio eaaeeoue
caeaoi?noue aeayeeo aioaaii?no?a eaeueoe?th aeea?ae?ii??eaeeiiaiai ?yaeo
iie?auoaaoe aiaeioae?aeueio ooieoe?th (Ferro C.J., Webb D.J., 1997).

?ai?oa aoei iienaii caeaoi?noue aeea?ae?ii??eaeeiiaeo AE niia?eueithaaoe
?icaeoie aoa?ineea?ico oa ii?iae?coaaoe ??aaiue oieanoa?eio a e?ia?, ui
iiaea aooe iia’ycaii c aieeaii oeueiai i?aia?aoo ia iaoaaie?ci
oieanoa?eio. Iieacaii, ui iiaeeo?eaoe?th iaoaaie?cio oieanoa?eio
aioaaii?noe eaeueoe?th cae?eniththoue ia ee?oeiiiio ??ai?, caiia?aath/e
ia?aaaioaaeaiith ?iiaie eaeueoe?th oa ooai?aiith ao???a oieanoa?eio.

Iaeiei ?c ia?niaeoeaieo AE inoaiiueiai iieie?iiy ? aieiaeei?i (Kass
R.S., Arena J.P., 1989). O ca’yceo c aenieith nii??aeiai?noth ?c
oinoie?i?aeiei a?oa?ii ee?oeiieo iaia?ai ? o?eaaeei ia??iaeii
iai?aaeaaaeaiiy aieiaeei?i iaioith i??ith ni?e/eiy? aeeeeeai?
aaciaeeeaoaoe??th iia?/i? aoaeoe, oa?aeoa?i? aeey AE
aeea?ae?ii??eaeeiiai? a?oie, iath/e aenieo aioea?ia?oaiceaio oa
aioeaia?iaeueio aoaeoeai?noue.

Iaaaaeai? aeai? na?ae/aoue, ui aea/aiiy aioea?ia?oaiceaii? aoaeoeaiino?
AE ii?yae ?c aeine?aeaeaiiyie NO-nenoaie oa e?i?aeiiai i?io?eth
ee?oeiieo iaia?ai iiaea ?icoe?eoe oyaeaiiy i?i iaoai?cie oi?ioaaiiy AA
oa aaciaeeeaooth/? iaoai?cie ae?? ei?ioeiae?th/eo oa i?ieiiaiaaieo AE
aeea?ae?ii??eaeeiiaiai ?yaeo ? ? aeooaeueiei o iaoeiaiio oa i?aeoe/iiio
ieai?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. I?iaaaeaii
aeineiaeaeaiiy ? neeaaeiaith /anoeiith iaoeiaiai iai?yieo ?iaioe
aiaeaeieo eeiii/ii? oa?iaeieiai? ?inoeoooo ea?aeiieiai? ii. aeaae.
I.Ae.No?aaeanea AII Oe?a?ie ca?aeii c oaiith “?ic?iaea iiaeo iaoiaeia
eeiiiei-oa?iaeieiai/iiai eiio?ieth ca aoaeoeaiinoth oa aaciaeith
canoinoaaiiy na?oeaai-noaeeiieo eie?a i caniaia ia iniiai iaia?aiieo
iaoaiiciia ?o aei?” aeiaia?? c Iii?noa?noaii Oe?a?ie o ni?aaao iaoee oa
oaoiieia?e oa ?inoeoooii ea?aeiieiai? ii. aeaae. I.Ae.No?aaeanea AII
Oe?a?ie, ca ?2/1837-97 a?ae 28 aeiaoiy 1997 ?ieo. 

Iaoa ? caaea/? aeineiaeaeaiiy. Aea/eoe aioeaiia?oaiceaio aoaeoeaiinoue
aioaaiiinoia eaeueoeith aeeaiae?iii?eaeeiiaiai ?yaeo i?ieiiaiaaii? ae??
c o?aooaaiiyi noaio eeioeiii? iaia?aie oa NO-nenoaie aeey c’ynoaaiiy
iiaeeeaeo iaoaiiciia aaciaeeeyooth/eo aoaeoia aioaaiiinoia eaeueoeith oa
iioeiicaoei? iiaeoiaeia aei aeai?o aoaeoeaii? aioeaiia?oaiceaii?
oa?ai??.

Aeey aeinyaiaiiy oei?? iaoe aoee iinoaaeai? oaei caaea/i:

1. Aecia/eoe eeiii/iee noai oai?eo ia AA o niianoaaeaiii c
oa?aeoa?enoeeith aee?iieeneioiiai neeaaeo eeioeiieo iaia?ai a?eo?ioeeoia
oa aiinoii iio?eo-aiiiio (NO2) a ia?eoa?e/iie e?iai oai?eo;

2. I?iaanoe ii?iaiyeueiee aiaeic aioeaiia?oaiceaii? aoaeoeaiinoi
ei?ioeiaeith/eo oa i?ieiiaiaaieo oi?i aioaaiiinoia eaeueoeith I
iieieiiiy (i?oaaeei?i) oa III iieie?iiy (aieiaeei?i) o ni?anoaaeaii? c
oa?aeoa?enoeeaie aee?iieeneioiiai neeaaeo ee?oeiieo iaia?ai a?eo?ioeeo?a
oa ai?noii NO2 o ia?eoa?e/i?e e?ia? oai?eo;

3. C’ynoaaoe iiaeeea? iaoai?cie aioea?ia?oaiceaieo aoaeo?a AE
i?ieiiaiaaii? ae?? i?oaaeei?io oa aieiaeei?io aeey iioei?caoe??
i?aeoiae?a aei aeai?o aoaeoeaii? aioea?ia?oaiceaii? oa?ai??.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoaoia. A ?acoeueoaoi i?iaaaeaieo
aeineiaeaeaiue anoaiiaeaii, ui i?e AA ?icaeaa?oueny ae?aaeaiee aeaoioeeo
noaaieueiiai iaoaaieioo ieneaeo acioo – NO2 a oeieueiie e?iai oa ??
ieacii. I?e oeueiio aiino NO2 a a?eo?ioeeoao inoioii c?inoa?. sse
ianeiaeie, ?icei ciaioo?oueny niiaaiaeiioaiiy ?iaaiue NO2 a
ieacii/?iaaiue NO2 a a?eo?ioeeoao, ui ia? aaaeeeaa aeiaeaoeiaa
eaai?aoi?ia aeiaaiinoe/ia cia/aiiy.

I?e AA niinoa?iaa?oueny inoioia cieaeaiiy ?iaiia aieiaieo na?aaeiuei-
oa aeiaaieaioethaeeiaeo aee?ieo eeneio: ii?enoeiiai?, iaeueiioeiiai? oa
noaa?eiiai?. I?e oeueiio cia/ii c?inoa? ?iaaiue aeayeeo iieiiaiane/aieo
aee?ieo eeneio n-6 ?yaeo,- a?aoiaeiiiai? oa aeieicao?e?iiai?. Oei oaeoe
na?ae/aoue i?i ii?ooaiiy e?i?aeiiai neeaaeo iaia?ai a?eo?ioeeo?a i?e AA.

Aia?oa aeyaeaii, ui aioaaiiinoe eaeueoeith aeeaiae?iii?eaeeiiaiai ?yaeo
ei?ioei? oa o?eaaei? aei? ? iiooaeieie iiaeoeyoi?aie aiinoo
iio?eo-aiiiio. I?ecia/aiiy iioaaeeiiio ei?ioei? oa o?eaaei? ae??, a
oaeiae aieiaeeiiio ii?yae ?c ii?iae?caoe??th AO ni?e/eiyei aei inoioiiai
c?inoaiiy ?iaiy NO2 a oeieueiie e?iai oa ?? ieacii, aei ciaioaiiy – a
a?eo?ioeeoao, a oaeiae aei ii?iae?caoe?? aee?iieeneioiiai neeaaeo
ee?oeiieo iaia?ai.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoaoia.  I?iaaaeaii aeineiaeaeaiiy
i?iaeaiiino?oaaee i?eioeeiiao iiaeeeainoue aeei?enoaiiy aecia/aiiy
aiinoo NO2 a e?iai oa eiao?oe??ioo ?iaaiue NO2 a ieacii / ?iaaiue NO2 a
a?eo?ioeeoao (eiao?oe??io I/A) ye aeiaeaoeiaiai eaai?aoi?iiai
ae?aaiinoe/iiai e?eoa?ith AA, oa o yeino? aeiaeaoeiaiai a?io?i?/iiai
oanoo aeey aecia/aiiy aoaeoeaiinoi aioeaiia?oaiceaii? oa?aii?.

Aecia/aiiy ai?noo NO2 a e?ia?, ?? ieaci? oa a?eo?ioeeoao ca iaoiaeii
“Niin?a e?euee?niiai aecia/aiiy i?o?eo-ai?iio a a?ieia?/i?e ??aeei?” c
iaoith aeiaeaoeiai? aiioiii/ii? aeiaaiinoeee AA ai?iaaaeaeaii o eeiii/io
i?aeoeeo aiaeaeieaiue ?inoeoooo ea?aeiieiai? ii. aeaae. I.Ae.No?aaeanea
AII Oe?a?ie. Oeae iaoiae aoa ?ic?iaeaiee niieueii c aiaeaeieii aiioii??
eiiiaeia (ea?iaiee – /eai-ei?. IAI oa AII Oe?a?ie I.I.Aoea) Iinoeoooo
aiioiii? ii. I.A.Iaeeaaeiia IAI Oe?a?ie, i caoeuaiee iiceoeaiei ??oaiiyi
i?i aeaea/o iaoaioo ia aeiao?ae a?ae 19.02.99 ?., ?a?no?aoe?eiee iiia?
cayaee 98095152 IAeOe iaoaioii? aenia?oece. Aii ca?ac aeei?enoiao?oueny
? a iaoeiaie ?iaioi Iinoeoooo aiioiii? IAI Oe?a?ie .

Iniaenoee aianie caeiaoaa/a  iieyaa? a eeiii/iiio ianoaaeaiii oai?eo,
eiio?iei ia?aaiao caoai?thaaiiy, ?iaeeaiaeoaeueiiio iiaeai?i noaie
oa?iaeioa?aii? AA, aiaeici eioa?aoo?ieo aeaieo.

Niieueii ic n.i.n. A.A.Eioeth?oaith (aiaeaeie aiioiiii? eiiiaeia
Iinoeoooo aiioiii? IAI Oe?a?ie) aea/aea aiino NO2 a oeieueiie e?iai?,
?? ieacii oa a?eo?ioeeoao.

Niieueii ic n.i.n. A.I.Eeiiaoaanueeei (aiaeaeie aiioiiii? eiiiaeia
Iinoeoooo aiioiii? IAI Oe?a?ie) aeineiaeaeoaaea ?iciiaeie aee?ieo eeneio
o iaia?aiao a?eo?ioeeoia. Naiino?eii i?iaaea noaoenoe/io ia?iaeo
io?eiaieo ?acoeueoao?a aeine?aeaeaiiy, aiaeic oa iaaiai?aiiy
?acoeueoaoia ?iaioe i?iaaaeaii niieueii c iaoeiaeie ea?iaieeaie.

Ai?iaaoeiy ?acoeueoaoia aeena?oaoei?.  ?acoeueoaoe i?iaaaeaieo
aeineiaeaeaiue aeiiiaiaeaeenue ia iaoeiaeo eiioa?aioeiyo ?inoeoooo
ea?aeiieiai? ii. aeaae. I.Ae.No?aaeanea AII Oe?a?ie (Ee?a, 1998-1999
??.), ia iaoeiai-i?aeoe/iie eiioa?aioei? “No/anii i?iaeaie ea?aeiieiai?
oa ?aaiaoieiai? (Ee?a, 1998), a oaeiae iecoei iiaeia?iaeieo neiiicioiia:
ia ?inienueeiio iaoeiiiaeueiiio eiia?ani “Ethaeeia oa e?ee” (Iineaa,
?iniy, 1998), ia XIII iiaeia?iaeiiio eiia?ani oa?iaeieiaia (Ithioai,
O?I, 1998), ia 6-io naioiaiio eiia?ani ii aaaeai na?oey (AEaiaaa,
Oaaeoea?iy, 1998), ia iiaeia?iaeiie eiioa?aioei? “Iioaineaa na?oeaaa
aeiiiiiaa” (??onaeei, Ic?a?eue, 1998), ia IX i?aeia?iaeiiio eiia?an? ii
a?ia?oaic?? (I?eai, ?oae?y, 1999). ?iaioa aoea caneooaia ia ni?eueiiio
can?aeaii? a?aeae?eaiue ee?i?/ii? oa?iaeieia??, anaioe?aeueii?
a?ia?oaic??, ee?i?/ii? a?io?i?? ?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.
No?aaeanea, oa a?aeae?eo a?io?i?? e?i?ae?a ?inoeoooo a?io?i?? ?i. I.A.
Iaeeaae?ia IAI Oe?a?ie.

Ioaeieaoei?.  Ii oaii aeena?oaoei? iioaeieiaaii 11 ?iaio (na?aae ieo –
4 noaooi o i?ia?aeieo iaoeiaeo aeo?iaeao, 1 ??oaiiy i?i aeaea/o iaoaioo
oa 6 oac).

No?oeoo?a oa ianya ?iaioe.  Aeena?oaoeiy neeaaea?oueny ci anooio, i’yoe
?icaeieia, iaaiai?aiiy iaea?aeaieo ?acoeueoaoia, aeniiaeia, i?aeoe/ieo
?aeiiaiaeaoeie oa nieneo eioa?aoo?e. ?iaioo aeeeaaeaii ia 125 noi?iieao
iaoeiiieniiai oaenoo, aiia iethno?iaaia 25 oaaeeoeyie oa 7 iaethieaie.
Aiaeiia?aoi/iee aeaciaiee iinoeoue 200 aeaea?ae (25 aio/eciyieo oa 175
ca?oaiaeieo).

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy.

Ianoaaeaii 98 oai?eo iiii?iith AA oa 17 i?aeoe/ii caei?iaeo in?a c
ii?iaeueieie oeeo?aie AO, ye? neeaee a?oio eiio?ieth. Na?aaeiie aie
iaoei?ioia neeaa 51,31,7 ?. O?eaaeinoue caoai?thaaiiy – 8,02,5 ?.
Ae?aaiic AA aenoaaeyany ia i?aenoaa? ?aeiiaiaeaoe?? AIIC (1997). A
/anoeie oai?eo (43 iniae) aoei aeyaeaii ioaii/io oai?iao na?oey (?ON) ia
iiaenoaai aeaieo aaeia?aiiao?i? (AAI) oa aiaiia?aoi? aiioeaaeo noaeei.
An?o oai?eo aeey ia?aeiiiai ianoaaeaiiy aini?oae?coaaee o a?aeae?e
ee?i?/ii? oa?iaeieia?? ?inoeoooo ea?ae?ieia?? ?i. aeaae. I.Ae.
No?aaeanea. Ianoaaeaiiy aeeth/aei, e??i caaaeueiiai ? o?c?eaeueiiai,
?yae oano?a aeey aeeeth/aiiy neiioiiaoe/ieo a?ia?oaic?e oa noiooi?o
caoai?thaaiue. Aeine?aeaeaiiy i?iaiaeeeenue aei iaaeeeaiaioicii? oa?ai??
? i?ney i?iaaaeaiiy eo?niaiai e?eoaaiiy i?oaaeei?iii ei?ioei? ae??
(Ei?eioa?, AWD) oa i?ieiiaiaaiieie oi?iaie AE ae?a?ae?ii??eaeeiiaiai
?yaeo – i?oaaeei?iii (Ei?eioa?-?aoa?ae, AWD) oa aieiaeei?iii (Ii?aane,
Pfizer). A e?ioe? 3-aeaiiiai aaciaaeeeaiaioiciiai ia??iaeo on?i oai?ei
aoei i?ecia/aii i?oaaeei?i ei?ioei? ae?? a aeic? 40-80 ia/aeiao no?ieii
ia 7-10 aei?a. I?ney oeueiai oai?eo ia AA aoei ?icae?eaii ia 2 a?oie (ca
aeiyoeii 20 oai?eo, ye? aoee aeeeth/ai? c aeine?aeaeaiiy a ca’yceo c
?icaeoeii iia?/ieo yaeu). Cacia/aia oa?ai?y i?aeae?aeany aei aeinyaiaiiy
AO ia aeua NAO 139 ii.?o.no. oa AeAO 89 ii.?o.no. Aei ia?oi? a?oie
oa?eoei 44 oai?eo ia AA, ye? i?eeiaee i?oaaeei?i o?eaaei? ae??
(Ei?eioa?-?aoa?ae, AWD) 40 ia/aeiao, no?ieii ia 7-10 aei?a oa 3
i?nyoe?. Ae?oaa a?oia aoea i?aaenoaaeaia 34 iaoe??ioaie, yeei i?ioyaii
aiaeia?/ieo no?ie?a aoei i?ecia/aii aieiaeei?i (Ii?aane, Pfizer) a aeic?
5-10 ia/aeiao (oaae. 1).

Oaaeeoey 1.

Ii??aiyia oa?aeoa?enoeea oai?eo ia AA aei e?eoaaiiy.

IieacieeeA?oie oai?eo, oeiiieaeoiaai? ca?aeii i?ecia/aiiy i?oaaeei?io
ei?ioei? ae?? (n-98)i?oaaeei?io o?eaaei? ae?? (n-44)aieiaeei?io

(n-34)A?e (?iee)50,061,151,141,2953,741,64Iayai?noue ?ON (in?a)431315NAO
(ii.?o.no.)1782,61831,81854,3AeAO (ii.?o.no.)1101,61131,71142,7Ioeuen
(oaea?e/oa.)69,00,9068,11,1367,00,98Oieanoa?ei
(ia/aee)2176,42106,52256,6E?aa ia?aaena?aey
(ni)3,790,063,830,063,800,05EAe? (ni)5,180,085,230,105,400,14EN?
(ni)3,500,083,500,093,780,14OIOI (ni)1,220,031,210,031,200,03OCN
(ni)1,110,021,100,021,130,03OA (%)61,90,7861,30,9058,91,02

Onii oai?ei aei??thaaany a?oa??aeueiee oene (AO), i?iaiaeeeinue
aeaeo?iea?ae?ia?ao?/ia aeine?aeaeaiiy (AEA). ?a?no?oaaee
no?oeoo?ii-ooieoe?iiaeuei? iieacieee i?iea?aeo eiaiai oeoii/ea ca
aeiiiiiaith iaoiaeo aoiea?aeiia?aoi? ia aia?aoi “Biomedica” ca
caaaeueiii?eeiyoith iaoiaeeeith (Iooa?eyiia I.I., Aaeaieia TH.I., 1981).
C ae?aaiinoe/iith iaoith oai?ei aoei i?iaaaeaii aaeia?aiiao??th (AAI),
aeine?aeaeaiiy i/iiai aeia ieoe?noii, a /anoei? oai?eo (17 in?a) –
AO-iii?oi??ia aei ? i?ney i?ecia/aiiy e?eoaaiiy. Aeayeei oai?ei (7 in?a)
aoei i?iaaaeaii ei?iia?iaaio?eeoeia?ao?th.

Caaaeueiee oieanoa?ei ieacie e?ia? aea/aee ca
aeiiiiiaith aacio?iiaoia?ao?/iiai aiae?co ia o?iiaoia?ao? “Carlo
Erba” (Ioaeiy), /anoeio aeine?aeaeaiue aoei aeeiiaii ca aeiiiiiaith
aiae?caoi?a “Cobas Fara” (Aano??y). sse a?ia?oieanoa?ieai?th aoei
?icoe?iaii ??aaiue oieanoa?eio aeuee ca 200 ia/aee.

Aiino aee?ieo eeneio aecia/aee ca aeiiiiiaith o?iiaoia?aoi? ia
aaci-?iaeeiiiio o?iiaoia?aoi “Carlo Erba” (Ioaeiy) c iiia?aaeiii
iaoeethaaiiyi c?aceia, ia eieiioe? c oacith Silar-5CP (Serva, O?I). Ca
?acoeueoaoaie o?iiaoia?ao?? i?ae?aoiaoaaee ni?aa?aeiioaiiy
iaiane/ai?/iane/ai? aee?i? eeneioe. Ia i?aenoaa? inoaiiueiai iieacieea
noaeeee i?i nooi?iue iaiane/aiino? e?i?ae?a o?iae a??o?ioeeo?a.
E?euee?noue NO2 a oe?euei?e e?ia?, ieaci? ? o?e//? a?aeieoeo
a??o?ioeeoao aecia/aee ca aeiiiiiaith ?aaeoeao A??na ca?aeii iaoiaeo,
?ic?iaeaiiio ni?eueii c? ni?a?ia?oieeaie ?inoeoooo a?io?i?? ?i.
I.A.Iaeeaae?ia IAI Oe?a?ie, yeee io?eiaa ??oaiiy i?i aeaea/o iaoaioo ia
aeiao?ae. Niin?a aeeth/a? aeiaeaaaiiy aei a?ieia?/ii? ??aeeie
noeueoinae?oeeeiai? eeneioe, oeaio?eooaoaaiiy, a?aeae?eaiiy
iaaeinaaeiai? ??aeeie, aeiaeaaaiiy aei ia? ?ic/eio A??na, aecia/aiiy
iioe/ii? aonoeie ??aeeie oa ia/eneaiiy ?acoeueoaoo.

Io?eiai? ?acoeueoaoe aeine?aeaeaiiy aoee noaoenoe/ii ia?iaeai? ?c
aeei?enoaiiyi t-e?eoa??y No’thaeaioa. A??ia?aeieie aaaaeaee ?acoeueoaoe
i?e ?

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