.

Алергічні дерматози у робочих машинобудівного виробництва (клініко-експериментальне дослідження): Автореф. дис… канд. мед. наук / С.Г. Лобашов, Укр.

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I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

OE?A?INUeEEE IAOEIAI- AeINE?AeIEE ?INOEOOO

AeA?IAOIEIA?? OA AAIA?IEIA??

Ia i?aaao ?oeiieno

EIAAOIA NA?A?E AAI??OIAE*

OAeE: 616.5-056.3:613.63/65.001.6-084

AEA?A?*I? AeA?IAOICE O ?IAI*EO IAOEIIAOAe?AIIAI AE?IAIEOeOAA

(EE?I?EI- AENIA?EIAIOAEUeIA AeINE?AeAEAIIss)

14.01.20. — oe??i? oa aaia?e/i? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a– 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Iaeanueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie

Iaoeiaee ea??aiee:aeieoi? iaaee/ieo iaoe, i?ioani?

Eiaaiianueeee Ae?a ?aaiiae/,

Iaeanueeee aea?aeaaiee iaaee/iee oi?aa?neoao, IIC Oe?a?ie,

caa. eaoaae?ith oe??ieo oa aaia?e/ieo caoai?thaaiue

Io?oe?ei? iiiiaioe:aeieoi? iaaee/ieo iaoe, aeioeaio, caa?aeoaa/
eaoaae?ith oa?ai?? c eo?nii aea?iaoiaaia?ieia?? Noinueeiai Aea?aeaaiiai
oi?aa?neoaoo Ai/a?ia Aaneeue Aiae??eiae/

aeieoi? iaaee/ieo iaoe, i?ioani? eaoaae?e oe??ieo oa aaia?e/ieo oai?ia
Caii??cueeiai Aea?aeaaiiai iaaee/iiai oi?aa?neoaoo E?ni?oeueeee Aiaoie?e
?aaiiae/

I?ia?aeia onoaiiaa:

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. aeaae. I.I.Aiaiiieueoey IIC
Oe?a?ie, i.Ee?a

Caoeno a?aeaoaeaoueny “_23__”__06__________1999 ?ieo i 10.00__aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.64.603.01 i?e Oe?a?inueeiio
iaoeiai- aeine?aeiiio ?inoeooo? aea?iaoieia?? oa aaia?ieia?? ca
aae?anith: 310057, i.Oa?e?a, aoe. *a?ieoaanueeiai 7/9 .

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oe?a?inueeiai
iaoeiai- aeine?aeiiai ?inoeoooo aea?iaoieia?? oa aaia?ieia?? (i. Oa?e?a,
aoe. *a?ieoaanueeiai 7/9).

Aaoi?aoa?ao ?ic?neaiee “_21___”___05_____1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee E.N.Oaoeueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca oiia iaoeiai- oaoi?/iiai i?ia?ano c?inoa? /enei
o?i?/ieo aaaio?a– aea?aai?a, ye? caeaoi? aeeeeeaoe ??ciiiai?oi? oi?ie
aea?a?/ieo o?aaeaiue, a oiio /ene? aea?aiaea?iaoice. A i?aeoeeo
ia?iaeiiai ainiiaea?noaa ai?iaaaeaeothoueny iia? o?i?/i? ?a/iaeie, ye?
iathoue ia?aeiiiiiae?acithth/? oa nainea?e?coth/? aeanoeaino?
(A.N.A?oeiia e niaao., 1977; A.A.Aioiiueaa e niaao., 1985; TH.I.Oaieia,
A.A.Eethaa, 1986; I?ioi?aieia e niaao., 1993; A.I.Aieeineaaneay, 1996;
N.I.Oaaei?ia e niaao., 1996; H.Schubert, E.Zachunka, 1989; G.B.Winton,
C.W.Lewis, 1992; S.Seidenari at al., 1994).

Oea ? iaei??th c i?e/ei oaeaeeiai ca?eueoaiiy /enea aea?a?/ieo
caoai?thaaiue, iniaeeai aea?iaoic?a o?i?/iiai aaiaco (Y.A.Aaoeaaa,
1975), ia?o ca ana a ?iaeono??aeueii ?icaeiooeo e?a?iao (A.Ae.Aaei,
1978; A.E.Neieoeui e niaao., 1988; Oaaei?ia N.I. e niaao., 1996;
R.Wolfin, J.Danis, 1984; J.Jidoi at al., 1995).

?iaioa i?enay/aia aeooaeuei?e i?iaeai?– aea/aiith aea?a?/ieo
aea?iaoic?a (AAe) o ?iai/eo iaoeiiaoae?aiiai ae?iaieoeoaa (IAA), eiei
ieoaiue aeey ae??oaiiy oe??? caaea/? ia? aea?aeaaia oa nioe?aeueia
cia/aiiy (A.A.Aaiieeia e niaao., 1981; A.Ae.Naeenneee e niaao., 1987;
Aaeeyiiaa TH.A. e niaao., 1998; e ae?.).

Ca?aeii c aeaieie A.A.Aioiiue?aa oa ni?aaao. (1979- 1991), i?iooai?iae
oe??e caeiathoue ia?oa i?noea na?aae i?ioan?eii? iaoieia??, ia ieo
i?eoiaeeoueny 1/2 an?o aeiaaee?a oei/aniai? ao?aoe i?aoeacaeaoiino?.

Aeai? i?i no?oeoo?o aea?aiaea?iaoieia?/ii? caoai?thaaiino? (AAeC) a
iaoeiiaoae?aiiio ae?iaieoeoa?, iioeiaeueieo noaiao e?eoaaiiy oa
i?io?eaeoeeo ? iaaeinoaoi?ie oa noia?a/eeaeie (A.A.Oaethaeaiei, 1972;
A.A.Niiia, A.E.Aeieaia, 1976; I.Ae.Aaaiiaa, 1984; A.E.Neieoeui e niaao.,
1988; A.A. Aioiiueaa e niaao., 1991; L.Hubasova at al.,1994; A.Alomar et
al., I995; P.J.Coenraads at al., 1995). Iaei??th c iniaeeainoae oe???
aaeoc? ia?iaeiiai ainiiaea?noaa ? canoinoaaiiy aaeeei? e?eueeino?
??ciiiai?oieo iiaeo eaei-oa?aiaeo iaoa??ae?a (EOI), ye?
aeei?enoiaothoueny ia aaaaoueio oaoiieia?/ieo eaieao. EOI i?noyoue iaei
aeine?aeaeai? o?i?/i? ?a/iaeie, ye? iio?aaothoue aeaoaeueii? ioe?iee ?o
aieeao ia i?aai?ci ethaeeie (O.O.Oa?/aiei,1984; Oee?oeueieeia A.I. e
niaao., 1988; Oaaei?ia N.I. e niaao., 1996; V.Pirila, 1992).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa ?
/anoeiith eiiieaenii? iaoeiai-aeine?aeii? ?iaioe IIC Oe?a?ie, yea
aeeiio?oueny ia eaoaae?? oe??ieo oa aaia?e/ieo caoai?thaaiue IAeIO (?
aea?ae?a?no?aoe?? 0196U001834).

Iaoith ae?enii? ?iaioe ? ?ic?iaea eiiieaeno e?eoaaeueieo oa
i?io?eaeoe/ieo caoiae?a ii cieaeaiith AAeC, aeeeeeaieo aieeaii EOI a
iaoeiiaoae?aiiio ae?iaieoeoa?.

Aeey ae??oaiiy oe??? i?iaeaie aoee iinoaaeai? oa aeine?aeaeai? ianooii?
caaea/?:

I. Aea/eoe ca 5 ?ie?a (1992- 1997 ?.?.) no?oeoo?o oa aeeiai?eo
aea?iaoic?a o ?iai/eo Iaeanueeeo caaiae?a “AII”, “Aoaea?ae?aae?ea” oa
caaiaeo “E?ayi”.

2. Aea/eoe o?aaeai?noue ?iai/eo caaiae?a aea?aiaea?iaoicaie c
anoaiiaeaiiyi nooiaiy ae?aciino? aea?a?/ieo ?aaeoe?e (A?).

3. I?aeoaa?aeeoe a aenia?eiaio? iiaeeea?noue aeieeiaiiy A? o
a?aeiia?aeue ia aieea neaaeeo aea?aai?a.

4. ?ic?iaeoe oa ai?iaaaeeoe eiiieaen ae?aaiinoe/ieo, e?eoaaeueii-
i?io?eaeoe/ieo caoiae?a aeey ?aiiueiai aecia/aiiy oai?eo, aoaeoeaiiai ?o
e?eoaaiiy oa iiia?aaeaeaiiy caoai?thaaiino?.

5. Ioe?ieoe aoaeoeai?noue ?ic?iaeaieo e?eoaaeueii- i?io?eaeoe/ieo
caoiae?a.

Iaoeiaa iiaecia io?eiaieo ?acoeueoao?a. Aia?oa iiaeeaeaii aea/aia
no?oeoo?a oa aeeiai?ea AAe ia i?eeeaae? aaeeeeo IAA, aecia/ai?
i?e/eiii-iane?aeeia? ca’ycee, aecia/ai? iaoiaaiaoe/i? iaoai?cie. C /enea
iaea?eueo /anoi aeei?enooaaieo EOI a IAA aecia/aii 6 ia?ie a?oio?a ?
aiaeae, ye? aeeeeeaee ??eoaoeai? oa oiene/ii-aea?a?/i? ?aaeoe?? o
?iai/eo iaoeiiaoae?aieoeoaa. Aia?oa i?iaaaeai? aeine?aeaeaiiy ii
a?aeoai?aiith A? a?ae ia?aaeaa/oaaieo aea?aai?a — EOI. Oiiae
aenia?eiaioo aeicaieeee o?ainoi?ioaaoe iaoiaeeeo nainea?e?caoe?? aeey
neeueieo aea?aai?a (?aoei?ii. ?1270). Aeey neaaeeo aea?aai?a aoea
aeei?enoaia iaoiaeeea A.?.Eiaaiianueeiai oa E.?.Cae?inueei? (a.n.
?1195978). Niaoeeo?ea io?eiaieo caiaeueieo ?aaeoe?e ia oe??? ii?nueeeo
naeiie, yeeo aoei nainea?e?ciaaii aeine?aeaeoaaieie EOI, aecia/eea
?ic?iaeo iiaiai niiniao ioe?iee ?aaeoe?e oe??e a aeine?ae?
“o?eieao-oano” (?aoei?ii. ?1331).

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue aia?oa i?e AAe o i?aoe?aiee?a
IAA a oe?ieiio ia’?i? oa eiiieaenii aea/ai? iieacieee oa?ii?aoeaioe?? ?
oaiia?aoo?ieo ?aaeoe?e, ?I oe??e, no?eeino? eai?ey??a oe??e (NEO),
aeaeo?e/iiai iii?o oe??e (AIO), aeai? ii?oieia?/iiai noaio ia?eoa?e/ii?
e?ia?, ai?noo anei?a?iiai? eeneioe (AE) a e?ia? oa aene?aoe?? ?? ?c
na/ath, ooieoe?iiaeueiee noai O- ? A- e?ioioeeo?a, O- ? A- ?iaeoeiaaieo
oaeia??a oa noi?ani??a a caeaaeiino? a?ae oi?ie aea?aiaea?iaoico oa
noaaeo ?iaioe ia ae?iaieoeoa?.

Aeey iiaeeeaino? ioe?iee aoaeoeaiino? cai?iiiiiaaiiai niiniao e?eoaaiiy
?ic?iaeaii oaoiieia?th aecia/aiiy NEO (aaeocaaa ?aoei?ii. ?622) ca
aeiiiiiaith i?eno?ith “aacaoiiao?a” (?aoei?ii. ?1242). Ai?iaaaeaeaia
iaeeieoey aacioanooaaiiy A/ni2 (e?euee?noue aeno?aaacao?a ia ieiu? a 1
ni2).

Aeey e?eoaaiiy AAe o ?ia?oiee?a IAA cai?iiiiiaai? ianooii? noaie
eiiieaenii? oa?ai??:

1. Niin?a e?eoaaiiy aea?aiaea?iaoic?a o?i?/iiai aaiaco (a.n. ?1526689),
yeee iieyaa? a oiio, ui ia oii? iaaeeeaiaioicii? oa?ai?? i?iaiaeyoue
e?eoaaiiy oeyoii aieeao aeiciaaiei aaeooiii. I?ney ooai?aiiy aaiaoiie
cae?eniththoue aeaeo?ioi?ac 1% ?ic/eiii anei?a?iiai? eeneioe.

2. Niin?a e?eoaaiiy aecaie (aaeocaaa ?aoei?ii.?1107), yeee aeeth/a?
iaaeeeaiaioicio (caaaeueiioe??iethth/o, naaeaoeaio, aeanainea?e?coth/o,
ciai?oith) oa?ai?th ? aieea aeiciaaiiai aaeooia c aeaeo?ioi?acii 1%
?ic/eio aaeanei?a?io.

Aia?oa, c iaoith iiia?aaeaeaiiy aoi?eiiiai ?io?eoaaiiy oa naiaoe??
i?e?io?aai, cai?iiiiiaaia ie?aea “Eica-1” — ?aoe.i?ii.?1607;
a?ae?ioiaia aaeoa?eoeeaeia ie?aea “Eica-2” — ?aoe.i?ii. ?1606;
a?ae?io?eueia ie?aea “Eica-3” — aaeocaaa ?aoei?ii.? 968.

Aia?oa ?ic?iaeaii noaiaea?oe oa e?eoa??? aoaeoeaiino? e?eoaaeueii-
i?io?eaeoe/ieo caoiae?a aeey i?aoe?aiee?a IAA. Aeey caaacia/aiiy
aeeniaina?iiai niinoa?aaeaiiy ?ic?iaeaia nenoaia e?euee?nii? ioe?iee
noaio caei?ia’y, i?eioeei?a iii?oi?oaaiiy noaio oai?iai ia AAeC.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Cai?iiiiiaai? ?ic?iaee
ai?iaaaeaeaii a i?aeoeeo ?iaioe iie?ee?i?ee caaiaeo ?i. “E?ayi”,
cae?aaieoeue caaiae?a “No?iea?ae?aaeeea” ? “NII”, a?aeae?ee oaoi?ee
aaciaee aeuaia?a?aoiaaieo i?aei?e?inoa, eaoaae?e oe??aaioai?ia
Iaeanueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, Iaeanueeiai IAe?
a??onieia??, Oe?a?inueeiai ?anioae?eainueeiai eai?ici??th, Iaeanueeiai
IOAAe ? AOAAe, oe??aaieaa?iao?a Oe?E A?oeecueeiai, A?ey?anueeiai,
E?e?enueeiai oa ?ioeo ?aeii?a Iaeanueei? iaeano?, Ia’?aeiaii?
cae?cie/ii? e?ea?i? ?1 i.Iaeane, Iaeanueei? aeeoy/i? i?eieia?/ii?
e?ea?i?, *a?iiii?nueei? aanaeiiai? ee?i?/ii? e?ea?i? ia aiaeiiio
o?ainii?o?, i?nueeeo oe??aaiaeeniaina??a i. Aeaaeeainoiea oa i.
Na?aoiaa. Oea aeicaieeei i?aeaeueoe aoaeoeai?noue ae?aaiinoeee,
e?eoaaiiy oa i?io?eaeoeee AAe.

Iniaenoee aianie aeena?oaioa. Aeena?oaio naiino?eii cae?enithaaa
ieaioaaiiy, i?iaaaeaiiy an?o aenia?eiaioaeueieo ? ee?i?/ieo
aeine?aeaeaiue, ocaaaeueiaiiy, noaoenoe/io ia?iaeo oa aiae?c io?eiaieo
aeaieo, noi?ioethaaa aeniiaee ?iaioe.

Ai?iaaoe?y ?iaioe. Iniiai? ?acoeueoaoe ?iaioe iaaiai?ai? ia can?aeaiiyo
c’?cae?a, i?aeia?iaeieo, ?anioae?eainueeeo, iaeanieo, oi?aa?neoaonueeeo
iaoeiaeo oa iaoeiai-i?aeoe/ieo eiioa?aioe?yo, ?anioae?eainuee?e
cono??/?, ia’?aeiai?e A/ai?e ?aae? IAeIO, Iaeanueeiio iaeaniiio
iaoeiaiio oiaa?enoa? aea?iaoiaaia?ieia?a, ia noi?niiio can?aeaii?
eaoaae? ? OIE “Oa?aiaaoe/i? niaoe?aeueiino?” IAeIO (02.11.98.).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? ?ic?iaeaii 2 aeiaoiaee, 5
aaeocaaeo ?aoei?iiiceoe?e, 10 ?aoei?iiiceoe?e, 1 iaoiaee/ia
?aeiiaiaeaoe?y, 2 ?ioi?iaoe?eieo eenoe, 10 ioae?eaoe?e, c yeeo 2 —
aeo?iaeuei? noaoo?.

No?oeoo?a oa ia’?i aeena?oaoe??. .?iaioa aeeeaaeaia ia 201 noi??ioe?
iaoeiiieniiai oaenoo ? neeaaea?oueny c aaaaeaiiy, iaeyaeo e?oa?aoo?e oa
aiae?co iaoa??ae?a ? iaoiae?a aeine?aeaeaiue, /ioe?ueio ?icae?e?a
?acoeueoao?a aeanieo aeine?aeaeaiue, aiae?co ? ocaaaeueiaiiy
?acoeueoao?a aeine?aeaeaiue, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e ?
nieneo e?oa?aoo?e, yeee neeaaea?oueny c 382 aeaea?ae, c yeeo 261
aeeeaaeaii ee?eeeoeath. ?iaioa ?ethno?iaaia 17 iaethieaie oa 35
oaaeeoeyie.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae oa iaoiaee aeine?aeaeaiue. Aeey ioe?iee aoaeoeaiino?
ai?iaaaeaeaiiy icaei?ia/eo caoiae?a ia Iaeanueeeo caaiaeao “NII”,
“Aoaea?ae?aae?ea” ? “E?ayi”, ie i?iaaee ii??aiyeueiee aiae?c aeeiai?ee
caaaeueii? aea?iaoieia?/ii? caoai?thaaiino? (CAeC) oa AAeC. Caaaeueiee
ia??iae aeine?aeaeaiue, yeee aeeth/aa ? ai?iaaoe?th ?ic?iaeaieo iaoiae?a
e?eoaaiiy ia 504 oai?eo ia AAeC neeaa c 1992 ii 1997 ?.?.

I?io?eaeoe/i? iaeyaee cae?eniaii o 2350 in?a, c yeeo 1336 ?iai/eo
aaciaeo i?ioan?e, neeaee iniiaio a?oio, a 1014 ?ia?oiee?a caaiae?a, ye?
aaciina?aaeiuei ia eiioaeooaaee c aea?aaiaie — eiio?ieueio A?oio
ii??aiyiiy neeaee 206 i?aeoe/ii caei?iaeo in?a — i?aoe?aieee
iie?ee?i?ee oa nooaeaioe.

Ia iiiaio ai?iaaoe?? ?ic?iaeaieo iaoiae?a e?eoaaiiy oa i?io?eaeoeee
i?iaeiaaeoaaei i?aoethaaoe a?eueo?noue in?a, ye? aoee aeine?aeaeai? ia
aoai? i?io?eaeoe/iiai iaeyaeo- a?aeiia?aeii 822 — iniiaiay a?oiia, 768
— eiio?ieueia oa 168 in?a aoei a a?oi? ii??aiyiiy. Ianoaaeaiiy
ia?aaeaa/aei ee?i?/iee iaeyae, i?iaaaeaiiy oe??ieo i?ia (a oe?eiio 12942
i?iae) oa ?ioiieia?/ieo aeine?aeaeaiue– aecia/aiiy ?AOE, Aa-?IE,
Ao-?IE, ooieoe?iiaeueii? aeoeaiino? O- ? A- e?ioioeeo?a, O- ? A-
?iaeoeiaaii? oaeia?ii? oa noi?ani?ii? aeoeaiino?– (anueiai 4314
?ioiioano?a).

Aenia?eiaioaeueia a?aeoai?aiiy AOAe oa oeo?oaaiiy aea?aai?a ae?iaie/iai
na?aaeiaeua i?iaaaeaii ia 117 ii?nueeeo naeieao. Oaa?eiai eiio?ieueii?
a?oie i?iaiaeeee aie?eaoe?? eneeieo, aacae?iiai? ie??, o?c?ic/eio
(I.I.Caeeai, A.A.Eaaeaaa, 1965; A.A. Eaaeaaa, 1974). An?i oaa?eiai
i?iaiaeeee caaaeuei? aiae?ce e?ia? oa na/?, ?NAE, OAI (I.A.Aeaenaaaa,
E.A.Aeoaaa, 1978; E.A.Aeoaaa e niaao., I980) (anueiai i?iaaaeaii 243
eiaeiiai aeaeo aeine?aeaeaiue). A e?ioe? aeine?aeo /anoeio ii?nueeeo
naeiie aeaeai?ooaaee c ianooiiei a?noieia?/iei aeine?aeaeaiiyi oe??e oa
aioo??oi?o i?aai?a ca caaaeueiii?eeiyoeie iaoiaeeeaie (A.I.Oeaaoeiaa,
E.N.Ia?neia, 1979; A.I. Oeaaoeiaa e niaao., 1981; A.I.Oeaaoeiaa,
A.I.Ii?aeiaoeaa, 1986).

I?ae iaoei niinoa?aaeaiiyi ciaoiaeeeinue 336 oai?eo ia aea?a?/iee
eiioaeoiee aea?iaoeo — AEAe, oa 168 — ia aecaio. A?eueo?noue oai?eo
neeaaeaee ae?iee –342(67,9%), /ieia?ee– 162(32,1%). 318 in?a(63,1%)
aoee iaea?eueo i?aoeacaeaoiiai a?eo 21-45 ?ie?a. O?eaae?noue
caoai?thaaiiy o 67,9% ia ia?aaeuoaaea 10 ?ie?a ? ua o 10,3% neeaaeaea —
21-25 ?ie?a. Iiia?aaeith oa?ai?th io?eioaaei 414(82,1%), ?c ieo–
98(19,1%) e?eoaaeenue noaoe?iia?ii. Cai?iiiiiaaio iaie oa?ai?th, yea
ia?aaeaa/aea aeei?enoaiiy aeiciaaiiai aaeooio(AeIA) oa aeaeo?ioi?aco
anei?a?iiai? eeneioe (AOAE) –AeIA/AOAE, io?eioaaei 292(57,9%). A oe?e
a?oi? (a iiaeaeueoiio- “aeine?aeia” a?oia) o 96(19%) aecia/aeanue
aecaia, o 192(38,9%) — AEAe. “Eiio?ieueio” a?oio neeaaeaee 212 (42,1%)
oai?eo, c yeeo 72(14,3%) no?aaeaeaee ia aecaio ? 140(27,8%) – ia AEAe. A
oe?e a?oi? i?iaiaeeeanue o?aaeeoe?eia oa?ai?y.

O in?a, yeeo niinoa??aaee i?iaiaeeee aeine?aeaeaiiy caaaeueiiai aiae?co
e?ia? (1012 ianoaaeaiue) (I.A.Aaca?iiaa, 1981). Aecia/aiiy ai?noo AE a
e?ia? oa na/? cae?enithaaee ca aeiiiiiaith aiia?ioeo?iiao?e/iiai iaoiaeo
O?eueiaina (692 aeine?aeaeaiue) (TH.I.Ino?ianeee, 1979; E.A.Aaca?iiaa,
1986). Ooieoe?iiaeueiee noai e?ioioeeoa?ii? nenoaie aecia/aee ca
caaaeueiii?eeiyoeie iieacieeaie ?AOE (i?e?iiiaeeo?eaoe?y), Aa?IE, Ao?IE,
a oaeiae iieacieeaie O-O-; O-A- ?iaeoeiaaii? oaeia?ii? oa noi?ani?ii?
aeoeaiino? (322 aeine?aeaeaiue), ui aeicaiey? aeaoe iaea?eueo ae/a?iio
oa?aeoa?enoeeo aca?iia?aeiinei i?ae ie?aieie oi?iaie e?ioioeeo?a
(Aaaaeaeaiyi I.A., 1987; Aeaaoiaa I.A., 1992; Clark A., 1994). Iieacieee
ooieoe?iiaeueiiai noaio oe??e– ?I (844 aeine?aeaeaiue ?I– ia ?I- iao??
EIO-0,1) (Aieueaeooaei A.I., A.A.Oea/, 1987), oaiia?aoo?o oe??e
(iaaee/iee aeaeo?ioa?iiiao? OIAI-1), aeaeo?ioe??iee ii??, ii?iae
oa?ii?aoeaioe?? oa aieueiai? /ooeeaino? (aia?ao Aeinu/aaa A.A. EAeO-1)
(796 cai???a) aecia/aee ye aaciina?aaeiuei a cii? a?aaeaiiy, oae ?
ia?eoieaeueii oa ia neiao?e/ieo ae?eyieao a aeeiai?oe? ia?aa?ao
caoai?thaaiiy. No?ee?noue eai?ey??a oe??e aei??thaaee ca aeiiiiiaith
aacaoiiao?a aeanii? eiino?oeoe??. Niaoeeo?/io /ooeea?noue oe??e
aecia/aee iaoiaeii e?aiaeueieo i?ia ca Aaae?iaei I.N.

?ic?iaeaia iaie noaia eiiieaenii? oa?ai?? AAe aaco?oueny ia ii?aeiaii?
ae?i?iaoe?eii?, caaaeueiioe??iethth/i?, aeanainea?e?coth/i?,
naaeaoeaii?, aeac?ioieneeaoe?eii?, ae??oe/ii?, iaoiaaiaoe/ii? oa?ai??
noi?iii?o caoai?thaaiue, ?iaeoeaoth/iai, aeaeo?io?c?ieia?/iiai oa
ciai?oiueiai e?eoaaiiy. Cacia/ai? eiiiiiaioe i?ecia/aeenue c o?aooaaiiyi
?iaeea?aeoaeueieo iniaeeainoae ia?aa?ao AAe.

I?iaaaeaiiy iniiaieo i?ioeaaeo? e?eoaaiiy (a.n.?1526689) ca iaoiaeeeith
AeIA/AOAE ia?aaeaa/aei aecia/aiiy no?eeino? eai?ey??a oe??e (NEO) ca
aeiiiiiaith 3- oaeeeiiiai aaeooiiiai aieeao (98,7 eIa) ia aioo??oith
iiaa?oith na?aaeiuei? o?aoeie ia?aaeie?//y ia ae?eyioe? ae?aiao?ii 20ii.
A?aeiia?aeii aei nooiaiy ae?aciino? NEO a iiaeaeueoiio aeei?enoiaothoue
aaeooii? ethaaoe c aiiioiaaiei aeoeaiei aeaeo?iaeii ieiuath a?ae 2 aei
10 ni2. Ca aeiiiiiaith aia?aoa AEI-02 aeicothoue aaeooiiee aieea a
caeaaeiino? a?ae NEO c iaoith a?aeoai?aiiy aaiaoii. I?ney i?eieiaiiy
aaeooiiiai aieeao i?iaiaeyoue aeaeo?ioi?ac 1% ?ic/eio anei?a?iiai?
eeneioe ia i?ioyc? 10- 15 oa.ca aeiiiiiaith aia?aoa “Iioie-1”.
U?euei?noue aeaeo?e/iiai no?oio i?ae aeoeaiei aeaeo?iaeii neeaaea? 0,05
iA/ni2. Aeaeo?ioi?aoe/i? naaine i?iaiaeyoue uiaeiaiai 5 ?ac?a ia
oeaeaeaiue.

Aiae?c ?acoeueoao?a aeine?aeaeaiue i?iaiaeeee c aeei?enoaiiyi
aa??aoe?eii- noaoenoe/ieo iaoiae?a aiae?co, ca e?eoa??yie ia?aiao?e/iiai
iaoiaeo ioe?iee aeinoia??iino? a?aei?iiinoae ?acoeueoao?a (Ae.Naiaoeeaa,
1968; A.E.Eociaoeia, 1978).

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. I?e aea/aii? AAeC oa CAeC
ia iaeanneeo caaiaeao “E?ayi”, “Aoaea?ae?aae?ea” oa “AII” ca 1992- 1997
?.?. c’yniaaii iayai?noue ia i?ioyc? 1992 ?ieo noaa?eueii? ieoiii? aaae
AAeC (7,4%)

Iae. 1. Aeeiai?ea caoai?thaaiino? oe??e ca 1992-1997 ?.?. o ?ia?oiee?a
caaiae?a a?oie eiio?ieth c o?aaeeoe?eieie iaoiaeaie e?eoaaiiy.

Ii in? aanoeen: ?iee, noiaa/eee ia ia?aaeiueiio ieai?– AAeC, ia
caaeiueiio — CAeC. Ii in? i?aeeiao: /enei aeiaaee?a caoai?thaaiue.

ia oii? a?aeiinii iecueei? CAeC (12,3%), ui ? iaioei a?ae aiaeia?/ieo
iieaciee?a a ?ioeo aaeocyo IAA(14,6 -21,4%) (A.N.?aaai, A.A. Aioiiueaa,
1975). I?e/iio, iaaea?a?/i? aea?iaoice aeyaeythoueny o oi?i? i?inoeo
eiioaeoieo aea?iaoeo?a, aea?aiaea?iaoice– o aeaeyae? aecaie,
e?iiea’yiee oa oieneaea?i??. Ii/eiath/e c e?ioey 1992 ?. iii?oii
c?inoathoue iieacieee CAeC ? a 1997 ?. caoai?thaai?noue o ii??aiyii? c
1992 ?. ? a 1,7 ?ace aeuith, a /enei aei?a iai?aoeacaeaoiino?- a?eueoei
a 1,4 ?ace, ieoiia aaaa na?aae an?o caoai?thaaiue – a 1,4 ?ace
a?eueoith. C?inoaiiy AAeC eaea a?eueo aenieeie oaiiaie ? a 1997 ?. a
ii??aiyii? c 1992 ?. caoai?thaai?noue ? a?eueoith a 7,9 ?ace, /enei
aei?a iai?aoeacaeaoiino?– a 5,9 ?ace, a ieoiia aaaa AAeC– a 4,7 ?ace.
A 1997 ?. o /ieia?e?a AAe niinoa??aaeenue a 5,8 ?ace /ano?oa, a o
ae?iie- a 9,6 ?ace. Ni?aa?aeiioaiiy caoai?thaaiino? o /ieia?e?a oa
ae?iie neeaei i?e CAeC (1: 1) oa AAeC (1: 2). Iaea?eueoa
?iciianthaeaeaiiy AAe iathoue o a?eia?e a?oi? aei 30 ?ie?a (49,3%), oa
i?e noaae? ?iaioe aei 10 ?ie?a (69,9%).

Aecaie oa aea?iaoeoe neeaaeathoue 88,5% a?ae on?o oi?i AAe ?
a?aeiia?aeathoue ca 94,6% an??? iai?aoeacaeaoiino?. Ni?a?aeiioaiiy i?ae
aecaiith oa aea?iaoeoaie a 1993 ?. aoei 1:4,8, a a 1997 ?. – 1:1,53.

Iaea?eueoa ieoiia aaaa AAeC i?eoiaeeoueny ia 8 iniiaieo oeao?a
caaiae?a(67,5%) ? /ano?oa ca ?ioeo oai??? 9 i?ioan?eieo a?oi (67,5%) –
?iai/eo, ye? ca nai?ie iaia’yceaie iathoue aenieee eiioaeo c EOI. A 3/4
aeiaaee?a oai?? eiioaeooaaee c aiaeeth AO-92-AN, AO-92-ON, IO-133c,
IO-133nn, a?oioaie AO-0119, OE-03-E.

Iiceoeaaoe?y oe??ieo ?aaeoe?e niinoa??aaeanue o 48,4% in?a iniiaii?
a?oie, c iaeiei aea?aaiii – o 27,4%, c aeaiia – 21%, c o?ueiia – 6,1%.
Aeei?enoai? a ?iaio? aea?aaie (OA, AE, OOA) ? a a?eueoino? eiiiiiaioaie
EOI. I?e iiaoi?iiio oanooaaii? i?ney i?iaaaeaiiy ?ic?iaeaieo caoiae?a
iiceoeaaoe?y a iniiai?e a?oi? cieceeanue aei 40,1% (P

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