Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao

Eao?e Aeaaeeneaa ?aaiiae/

OAeE: 616.127-005.8-085.225.2:611.018.74:577.112.08

Aeoeai?noue aiaeioae?io-1 oa ieneaeo acioo i?e aino?iio ?ioa?eo?
I?iea?aeo a aeeiai?oe? e?eoaaiiy ?ia?a?oi?aie
aia?ioaicei-ia?aoai?thth/iai oa?iaioo

14.01.11 – ea?ae?ieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai

nooiaiy eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? oa?ai?? AII Oe?a?ie, i. Oa?e?a.

Iaoeiaee ea??aiee: — aeaaeai?e IAI, AII Oe?a?ie, oa ?AII,
aeieoi? iaaee/ieo

iaoe, i?ioani? Iaea Ethaia
O?ioei?aia, aee?aeoi? ?inoeoooo

oa?ai?? AII Oe?a?ie, i.
Oa?e?a.

Io?oe?ei? iiiiaioe:

— aeieoi? iaaee/ieo iaoe, Aeanaiei Ieoaeei Aioiiiae/, caa. eaoaae?ith
oa?ai?? oa iao?ieia?? Oa?e?anueei? iaaee/ii? aeaaeai?? i?neyaeeieiiii?
ina?oe IIC Oe?a?ie, i. Oa?e?a;

— aeieoi? iaaee/ieo iaoe, Eacaeia TH??e Ieoaeeiae/, i?ioani?, caa.
eaoaae?ith oa?ai??, ea??aiee i?iaeaiii? iaoeiai-ae?aaiinoe/ii?
eaai?aoi??? aeaaeai??.

Oe?a?inueea iaaee/ia noiiaoieia?/ia aeaaeai?y, i. Iieoaaa,

I?ia?aeia onoaiiaa:

?inoeooo ea?ae?ieia?? ?i. I.Ae. No?aaeanea AII Oe?a?ie, i. Ee?a,
a?aeae?e ?ioa?eoo i?iea?aea oa a?aeiiaethaaeueiiai e?eoaaiiy

Caoeno a?aeaoaeaoueny 23 aa?aniy 1999 ?., i 1230 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04, i?e
Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?, ca aae?anith:
310022, i. Oa?e?a, i?. Eai?ia 4

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, 310022, i. Oa?e?a, i?. Eai?ia 4.

Aaoi?aoa?ao ?ic?neaiee “__03__ ” ___na?iiy____ 1999?.

A/aiee nae?aoa?

Niaoe?ae?ciaaii? a/aii? ?aaee,

e.i.i., aeioeaio
E.?. Ia/a?aiei

caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. Na?aae caoai?thaaiue na?oeaai-noaeeiii? nenoaie
aaaeeeaa ?ieue iaeaaeeoue aino?iio ?ioa?eoo i?iea?aeo (?I), ye iaei?e c
i?e/ei i?ia?anoaaiiy ?oai?/ii? oai?iae na?oey (?ON), ?iaae?aeecaoe?? oa
nia?oiino? na?aae ianaeaiiy. O c’ayceo c oeei i?iaeaia ?icoi?iiy
iaoio?c?ieia?/iiai ia?aa?ao i?ioeano o eiie?aoiiai oai?iai oa
iiaeaeueoiai i?ecia/aiiy eiio ?aoe?iiaeueii? oa?ai?? iaaoaa? ana
a?eueoiai cia/aiiy. O na?o? no/anieo aeaieo aaeeea oaaaa i?eae?ey?oueny
ieoaiiyi ii?ooaiiy ooieoe?? aiaeioae?th i?e aino?iio ?I (Yasue H., 1997;
Ikeda K., 1997).

Aea/aiiy ooieoe?iiaeueieo ii?ooaiue aiaeioae?th a ii?i? oa i?e iaoieia??
ia? aaeeea cia/aiiy ye aeey ?icoi?iiy iaoiaaiaoe/ieo iaoai?ci?a
caoai?thaaiue na?oeaai-noaeeiii? nenoaie, oae ? aeey ?ic?iaee iiaeo
?aoe?iiaeueieo oeyo?a ?o oa?iaeieia?/ii? ei?aeoe??.

*eneaii? aeine?aeaeaiiy, ni?yiiaai? ia aea/aiiy iaoai?ci?a ae??
?ia?a?oi??a aia?ioaicei-ia?aoai?thth/iai oa?iaioo (?AIO), aecia/eee iia?
aniaeoe canoinoaaiiy oe??? a?oie i?aia?ao?a o oai?eo ia aino?ee ?I oa
na?oeaao iaaeinoaoi?noue (NI) (Genoni M., 1996). Iaeiae ?acoeueoaoe
aeine?aeaeaiue canoinoaaiiy ?AIO o oai?eo ia aino?ee ?I noia?a/eea?
(Jeremic G. 1996, Desta B., 1995). O c’ayceo c oeei ?ieue oa
aeioe?euei?noue aeei?enoaiiy oe??? a?oie i?aia?ao?a o oaeeo iaoe??io?a
iio?aao? iiaeaeueoiai aea/aiiy.

Caeeoathoueny iaeiaea/aieie ?ieue aiaeioae?e-caeaaeieo iaoai?ci?a
aacieiino??eoe?? oa aaci?aeaenaoe?? a ?aae?caoe?? aoaeo?a ?AIO noiniaii
aei ci?i ia?aiao??a oeaio?aeueii? oa ia?eoa?e/ii? aaiiaeeiai?ee oa
aeoeaiino? eae?e?a?i-e?i?iiai? nenoaie. Ia ?ic?iaeaii i?aeoiaee aei
aeeoa?aioe?eiiai canoinoaaiiy ?AIO i?e aino?iio ?I ia iniia? noaio
aiaeioae?aeueii? aeenooieoe?? oa ?? ci?ie a aeeiai?oe? e?eoaaiiy oai?eo
ia aino?ee ?I.

Aeeeaaeaia aeiaiaeeoue aeooaeuei?noue aea/aiiy ae?? ?AIO ia
aiaeioae?e-caeaaei? iaoai?cie ?aaoeyoe?? noaeeiiiai oiiono o oai?eo ia
aino?ee ?I.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Iiaeaia ?iaioa
aeeiiaia a ?aieao oaie Iae?: “Aea/aiiy iaoiaaiaoe/ieo iaoai?ci?a
?aia?ooc?? oa ?ic?iaea iiaeo iaoiae?a ?aia?ooc?eii?
oa?ai?? aino?iai ?ioa?eoo i?iea?aeo”, ? 0197U008304
aea?ae?a?no?aoe?? a?aeae?eo aino?iai ?ioa?eoo i?iea?aeo ?inoeoooo
oa?ai?? AII Oe?a?ie ia aac? niaoe?ae?ciaaiiai ?ioa?eoiiai a?aeae?eaiiy
oa a?aeae?eaiiy ?aai?iaoe?? oa ?ioaineaii? oa?ai??.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe aoei i?aeaeuaiiy
aoaeoeaiino? iaaeeeaiaioicii? oa?ai?? aino?iai ?ioa?eoo i?iea?aea oa
?ic?iaoe? e?eoa???a ?iaeea?aeoae?ciaaii? oa?ai?? ?ioa?eoo i?iea?aea.

Aeey aeinyaiaiiy iinoaaeaii? iaoe noaaeeenue oae? caaaeaiiy:

Aea/eoe iaoai?cie aiaeioae?e-caeaaeii? aacieiino??eoe?? oa
aaci?aeaenaoe?? o oai?eo c ??ciiiai?oiei ee?i?/iei noaiii ia?aa?ao
aino?iai ?I;

Aecia/eoe aca?iica’ycie iieaciee?a aiaeioae?e-caeaaeii? aacieiino??eoe??
oa aaci?aeaenaoe?? c ee?i?/ieie oa ia?aee?i?/ieie ia?aiao?aie;

I?iaanoe ee?i?ei-a?io?i?/io ioe?ieo aoaeoeaiino? oa?ai?? ?AIO, o oai?eo
ia ?I;

Aea/eoe aeeiai?eo iieaciee?a aiaeioae?e-caeaaeii? aacieiino??eoe?? oa
aaci?aeaenaoe?? oa eae?e?a?i-e?i?iiai? nenoaie a i?ioean? e?eoaaiiy
?AIO;

?ic?iaeoe e?eoa??? i?iaiico aoaeoeaiino? oa?ai?? ?AIO.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Iiaecia aeaii? ?iaioe iieyaa?
a oiio, ui aia?oa ca aeiiiiiaith nenoaiiiai aiae?co aea/aii niaoeeo?eo
no?oeoo?ii? ia?aaoaeiae ooieoe?iiaeueieo nenoai i?aai?cio oai?eo ia ?I,
o aeeiai?oe? e?eoaaiiy ?AIO. Aia?oa aecia/aii e?eoa??? i?iaiico
aoaeoeaiino? oa?ai?? ?AIO oa anoaiiaeaii i?iaiinoe/io ?ioi?iaoeai?noue
ee?i?ei-ooieoe?iiaeueieo ? a?io?i?/ieo ia?aiao??a. Oaeiae aeiaaaeaii, ui
oa?aiaaoe/ia aoaeoeai?noue ?AIO noi?iaiaeaeo?oueny iie?auaiiyi
aiaeioae?aeueii? ooieoe??. Iaa?oioiaaia iaea?eueo ni?eyoeeaa ae?y
eiia?iiaaii? oa?ai?? ?AIO oa o?iiaie?oee?a ia iaoai?cie
aiaeioae?e-caeaaeii? aacieiino?eeoe?? oa aaci?aeaenaoe?? i?e aino?iio
?I.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. cia/aiiy ?iaioe iieyaa? a
oiio, ui aeiaaaeaii aeioe?euei?noue eiia?iiaaiiai canoinoaaiiy ?AIO oa
o?iiaie?oe/ii? oa?ai?? na?aae ?ioeo eiia?iaoe?e iaaeeeaiaioicieo
cania?a. ?ic?iaeai? i?iaiinoe/i? aeai?eoie aeicaieythoue ee?i?oeenoo
?iaeea?aeoaeueii ni?yiiaoaaoe oa?ai?th aino?iai ?I, a oaeiae ioe?ieoe
noai ooieoe?iiaeueieo ii?ooaiue aiaeioae?th ca aeiiiiiaith ee?i?/ieo oa
ia?aee?i?/ieo aeaieo.

?acoeueoaoe iaoeiaeo aeine?aeaeaiue (“I?ia?aia ?iaeea?aeoae?ciaaiiai
e?eoaaiiy aino?iai ?ioa?eoo i?iea?aea”, “Niin?a i?iaiicoaaiiy
oneeaaeiaiiai oa iaoneeaaeiaiiai ia?aa?ao aino?iai ?ioa?eoo i?iea?aea”),
ai?iaaaeaeaii o i?aeoeeo e?eoaaeueii-i?io?eaeoe/ieo caeeaae?a i.
Oa?eiaa: iaeani?e ee?i?/i?e e?ea?i?, ?inoeooo? oa?ai?? AII Oe?a?ie,
iaeanieo iaaee/ieo caeeaaeao: Ci??anueea Oe?E, Iieoaanueeee iaeaniee
ea?ae?ieia?/iee ae?niaina?. Aoaeoeai?noue ai?iaaaeaeaiiy a?aeia?aceeanue
o a?aeiiniiio ciaioaii? /ano ia?aaoaaiiy oai?iai o e?ea?i? oa ciaioaii?
o?iainiaeo aeo?ao ia e?eoaaiiy.

iniaenoee aianie caeiaoaa/a. Aeena?oaoe?eia ?iaioa aoea aeeiiaia i?ae
/an iaa/aiiy a ani??aioo?? ia aac? ?inoeoooo oa?ai?? AII Oe?a?ie.
Aeena?oaio cae?enithaaa i?aea?? oaiaoe/ieo oai?eo, caaacia/oaaa ?o
ianoaaeaiiy, eiio?ieue ca aoaeoeai?noth e?eoaaiiy. Caeiaoaa/ naiino?eii
canoiniaoaaa oae? iaoiaee aeine?aeaeaiiy oai?eo, ye aecia/aiiy
aiaeioae?io-1 (AO-1) ?aae?i?ioiieia?/iei iaoiaeii, aecia/aiiy
eiioeaio?aoe?? oeeee?/ieo ioeeaioeae?a, e?i?aeiiai niaeo?o e?ia?
?ioiioa?iaioiei iaoiaeii, aecia/aiiy aeoeaiino? eae?e?a?io (EE) oa
i?aeae?e?a?io (EA), a?iioaeai?/iiai iao??e-o?aoe/iiai ai?iiio (IOA) oa
Na-K-AOOace niaeo?ioioiiao?e/iei iaoiaeaie.

ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy oa ?acoeueoaoe
aeena?oaoe?? aoee iaaiai?ai? ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo
?inoeoooo oa?ai?? AII Oe?a?ie (Oa?e?a, 1997-1998??.), ?anioae?eainuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? iieiaeeo a/aieo ? niaoe?ae?no?a
(Oa?e?a, 1997 oa 1999??.), aoea c?iaeaia aeiiia?aeue ia ?a?iiaenuee?e
eiioa?aioe?? iieiaeeo a/aieo (Aa?e?i, 1997, 1998??.), I i?aeia?iaeiiio
c’?cae? iieiaeeo a/aieo (Oa?iii?eue, 1997?.).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 10 iaoeiaeo i?aoeue.
?c ieo 4 — a iaoeiaeo oaoiaeo aeaeaiiyo.

No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 226 ae?oeiaaieo
noi??ieao, oa neeaaea?oueny c oaeeo ?icae?e?a: anooio, aeaio ?icae?e?a
iaeyaeo e?oa?aoo?e, /ioe?ueio ?icae?e?a aeanieo niinoa?aaeaiue,
caeeth/ii? /anoeie, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo
aeei?enoaii? e?oa?aoo?e, yeee aeeth/a? 284 aeaea?aea: 49 ?in?enueeeo oa
oe?a?inueeeo aeaea?ae, 245 ?iicaiieo, ui neeaaea? 32 noi??iee,
?ethno?iaaia 30 oaaeeoeyie, 27 iaethieaie oa 5 noaiaie, ye? caeiathoue
50 noi??iie.

iniiaiee ci?no ?iaioe

Iaoa??aee ? iaoiaee aeine?aeaeaiiy.

I?e aeeiiaii? ?iaioe ianoaaeaii 122 oai?eo ia aino?ee ?I, ye?
ciaoiaeeeenue ia e?eoaaii? o a?aeae?eaii? ?aai?iaoe?? ?inoeoooo oa?ai??
AII Oe?a?ie. A?e oai?eo eieeaaany a?ae 33 aei 69 ?ie?a. na?aaei?e a?e
53,02 + 11,31 ?ie?a. Na?aae ianoaaeaieo oai?eo aoei 110 (90.1%)
/ieia?e?a ? 12 (9.9 %) ae?iie.

Na?aae ieo 86 (70,5%) oai?eo no?aaeaeaee ia noaa?eueio noaiiea?ae?th
??cieo ooieoe?iiaeueieo eean?a, a 52 (42.6%) oai?eo ia ianoaa?eueio
noaiiea?ae?th a inoaii? 5-20 aei?a. O 12 (9,8%) oai?eo ?ON
iai?oanooaaea ?icaeoeii aino?iai ?I. A?oa??aeueiith a?ia?oaic??th, a
aiaiiac?, no?aaeaeaee 78 (63.9%) oai?eo. ?I aoa ia?aeiiei o 98 (80,3%)
oai?eo. O a?oi? oai?eo c iiaoi?iei ?I ae?oaei ca ?aooieii a?i aoa o 20
/ieia?e?a, a o?ao?i o 4 oai?eo.

Aei aeine?aeaeaiiy aoee caeo/ai? oai?? ia aino?ee ?I o?eueee e?aiai
oeoii/ea. Ia?aaei?e ?I aoa ca?a?no?iaaiee o 72 (59,9%) oai?eo, ieaei?e
?I o 50 (40,1%) oai?eo. Ca aeaieie AEA o 70 (57,37%) oai?eo
a?aei?/aii o?ainio?aeueiee ?I (Q-coaaoeue), o 52 (42,63%) ?I aac
Q-coaoey. Iaaeinoaoi?noue e?iaiia?ao o?enoaaeany ca eeaneo?eaoe??th
Killip oa M.G.Wolk (1972). Aoei ca?a?no?iaaii 56 (45,9%) oai?eo c NI
a?aeiia?aeii Killip I, 62 (50,81%) oai?eo a?aeiia?aeii Killip II, oa 4
(3,27%) oai?eo a?aeiia?aeii Killip III. Ae?aaiic noaaeany ia i?aenoaa?
aiae?co nea?a oai?eo, ee?i?/ieo aeaieo oa ?acoeueoao?a
?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy. Ianoaaeaii oaeiae 20
caei?iaeo in?a (aeiii??a), ye? neeaee a?oio eiio?ieth.

Aoiea?ae?ia?ao?/ia ianoaaeaiiy i?iaiaeeeiny ia aoiea?ae?ia?ao? «O? 628A»
(Oe?a?ia) a iaeii- ? aeaii??iiio ?aaeeiao aeine?aeaeaiiy c ai?eaeueii?
oa ia?anoa?iaeueii? iiceoe?e ca caaaeueiii?eeiyoith iaoiaeeeith
(Iooa?eyiia H.I., 1987).

E?ia aeey a?io?i?/ieo aeine?aeaeaiue a?aee i?ae /an aini?oae?caoe??,
/a?ac 24 aiaeeie, ia 5oo oa 10oo aeiao. aeoeai?noue eae?e?a?i-e?i?iiai?
nenoaie a ieaci? e?ia? aecia/aee ca iaoiaeeeith, cai?iiiiiaaiith
Iano?iith O.N oa E?einueeith A.A. (1974?.). eiioeaio?aoe?y aiaeioae?io-1
(AO-1) a ieaci? e?ia? aecia/aee ?aae?i?ioiieia?/iei iaoiaeii
(noaiaea?oi? iaai?e o??ie «DRG», NOA), ??aaiue oeeee?/ieo ioeeaioeae?a
o ieaci? aecia/aee ca aeiiiiiaith noaiaea?oiiai iaai?o o??ie AO
«A?i?ioiiaai» (?in?y, i. Iineaa). e?i?aeiee niaeo? e?ia? aecia/aee
?ioiioa?iaioiei iaoiaeii. Aecia/aiiy ??aiy a?iioaeai?/iiai
iao??e-o?aoe/iiai ai?iiio (IOA) i?iaiaeeee niaeo?ioioiiao?e/iei
iaoiaeii. Aecia/aiiy aeoeaiino? Na-K-AOOace iaia?ai a?eo?ioeeo?a
i?iaiaeeee ca iaoiaeii Y.A.Oaaeioiaa (1984).

Iaoaiaoe/ia ia?iaea ?acoeueoao?a i?iaaaeaia ca aeiiiiiaith AII ?c
canoinoaaiiyi iaeaoo i?eeeaaeieo i?ia?ai aeey noaoenoe/ii? ia?iaee
?ioi?iaoe?? «EXEL» ? FOXPROL. A??ia?aei?noue ??cieoeue aecia/aee ca
aeiiiiiaith e?eoa??y t-Nouethaeaioa. Canoiniaaiee nenoaiiee aiae?c
i?iaiaeeany iaoiaeii ei?aeyoe?eieo no?oeoo?.

?acoeueoaoe aeine?aeaeaiiy

Aiae?c aoii?aeueiiai niaeo?o e?ia? o oai?eo c o?ainio?aeueiei ?I, o
ia?oo aeiao iieacaa (oaa. 1), ui ??aaiue AO-1 o oai?eo ia ?I
a??ia?aeii ia?aaeuoaaa iieacieee a?oie

eiio?ieth (p<0.001). Oaaeeoey 1 Ci?no aeayeeo iae?iaoii?aeueieo iieaciee?a o oai?eo c aino?ei o?ainio?aeueiei ?I a ia?oo aeiao caoai?thaaiiy (M + m). IIEACIEE A?oie niinoa?aaeaiiy ? t Oai?? ?I (n=81) Eiio?ieue (n=20) AO-1 (ia/ie) OeAIO(iiieue/e) IOA (ieiieue/e) EA (iaae/ie) EE (iaae/ie) Na-K-AOOaca (iiieue/e) 18.78 + 0.71 20.21 + 0.72 48.39 + 0.24 156.80 + 9.73 169.57 + 7.71 2.7 + 0.07 8.24 +1.41 7.14 + 1.32 22.31 + 2.47 402.34 + 13.51 52.33 + 4.23 4.2 + 0.09 < 0.001 <0.001 < 0.001 < 0.001 < 0.001 < 0.001 6.7 8.7 10.4 14.7 13.3 13.2 Aeniei a??ia?aeia i?aeaeuaiiy oaeiae ca?a?no?iaaii a?aeiinii IOAa (p<0.001), a oaeiae i?eai?/aiiy iei aeoeaiino? Na-K-AOOace a?eo?ioeeo?a. Ii?yae ?c i?aeaeuaiiyi aeoeaiino? aacieiino??eoi?ieo oaeoi??a, aeyaey?oueny oaeiae i?aeaeuaiiy aeoeaiino? iae?iaoii?aeueieo oaeoi??a c aaciae?eyooth/ith ae??th: oeAIO (p<0.001) oa eiiiiiaio?a eae?e?a?i-e?i?iiai? nenoaie - EA (p<0.001), EE (p<0.001). Oea na?ae/eoue i?i aeoeaaoe?th ye aacieiino??eoi?ieo oae ? aaciae?eyooth/eo oaeoi??a ?aaoeyoe?? noaeeiiiai oiiono a ia?oo aeiao o?ainio?aeueiiai ?I. Aecia/aiiy nooiaiy a?aeoeeaiiy a?ae ii?ie eiaeiiai c iieaciee?a, ca aeiiiiiaith ii?iiaaiiai t-e?eoa??th iieacaei, ui aei ia?oi? o??eee aeine?aeaeaieo oaeoi??a (ca aaee/eiith t-e?eoa??th) oa?eoee: EA (14.7) TH EE (13.3) TH Na-K-AOOaca (13.2), ui na?ae/eoue i?i ia?aaaaeio aeoeaaoe?th eae?e?a?i-e?i?iiai? nenoaie (aaciae?eyoaoe??), a?aeiinii aeoeaaoe?? ?ioeo iae?iaoii?aeueieo nenoai ye? aea/aee, oa i?ecaiaeeoue aei oi?ioaaiiy oiia aeaaii?e?iieo aeey caaeeaeaiiy o?aaeaiiai i?iea?aeo. I?e ?I aac Q-coaoey, aaaaoioaeoi?iee aiae?c ca aeiiiiiaith t-e?eoa??th, iieacaa (oaa. 2), ui aei ia?oi? o??eee ia?aiao??a, ca aaee/eiith ?o a?aeoeeaiiy a?ae iieaciee?a eiio?ieueii? a?oie, oa?eoee: Oaaeeoey 2 Ci?no aeayeeo iae?iaoii?aeueieo iieaciee?a o oai?eo c aino?ei ae??aiiaiaiaaei ?I (aac coaoey Q) a ia?oo aeiao caoai?thaaiiy (M + m). IIEACIEE A?oie niinoa?aaeaiiy ? t Oai?? ?I (n=81) Eiio?ieue (n=20) AO-1 (ia/ie) OeAIO(iiieue/e) IOA (ieiieue/e) EA (iaae/ie) EE (iaae/ie) Na-K-AOOaca(iiieue/e) 14.39 + 0.93 10.54 + 1.12 47.80 + 0.26 263.61 + 14.22 90.90 + 5.84 2.75 + 0.08 8.24 ±1.41 7.14 + 1.32 22.31 + 2.47 402.34 + 13.51 52.33 + 4.23 4.2 + 0.09 < 0.001 <0.05 < 0.001 < 0.001 < 0.001 < 0.001 3.6 2.0 10.3 7.1 5.4 12.1 Na-K-AOOaca (12.1) TH IOA (10.3) TH EA (7.1), ui na?ae/eoue i?i aeao?oeeo aaciaeeeyoaoi?ieo oa aeii?ioaaiiy ia 81.2% aeoeaiino? aacieiino??eoi?ieo oaeoi??a ye? aea/aee, iaae aaciae?eyooth/eie oa aeaco? ia iaaeinoaoi?noue eiiiainaoe?? iaoai?ci?a ?aaoeyoe?? noaeeiiiai aiiainoaco. Io?eiai? ?acoeueoaoe iiaeia ioa?aeoa?ecoaaoe c iiceoe?? ??ciini?yiiaaiino? oi/ie i?eeeaaeaiiy iaoiaaiaoe/ieo oaeoi??a: ?ic?eao aoa?ineea?ioe/ii? aeyoee c iiaeaeueoei ?icaeoeii o?iiaico ei?iia?ii? a?oa??? oa?aeoa?iei aeey a?eueoino? o?ainio?aeueieo ?I, oa aaciniacio ei?iia?ii? a?oa???, ui iiaea noaoe i?e/eiith i?ia?anoaaiiy ianoaa?eueii? noaiiea?ae?? c iiaeaeueoei o?ainoi?ioaaiiyi a ?I. C ?ioiai aieo aeii?ioaaiiy aacieiino?eeoi?ieo oaeoi??a i?e ae??aiiaiaiaaiio ?I iiaea na?ae/eoe i?i iani?eyoeeaee i?iaiic, uiaei i?io?aaiaaii? oa/??, o?ainio?ae?caoe?? ?I, ?icaeoeo ?aoeeaeea?a oa iiaoi?ieo ?ioa?eo?a. C iaoith aea/aiiy aieeao oa?ai?? ?AIO ia aeeiai?eo iae?iaoii?aeueieo iieaciee?a noaeeiiiai aiiainoaco a i?ioean? e?eoaaiiy ?I aoei ianoaaeaii aea? a?oie oai?eo, iaeia c yeeo io?eioaaea o?aaeeoe?eio oa?ai?th (o?iiaie?oe/io oa?ai?th, i?o?aoe, aaoa-aeieaoi?e, ani??ei, aaia?ei), a ?ioa ia oii? o?aaeeoe?eii? oa?ai?? io?eioaaea i?aia?aoe ?AIO (aiaeai?eea iaeaao o aeic? 5 – 20 ia ia aeiao). I?e i?eeii? ?AIO, aoei a?eueo a??ia?aeia i?eai?/aiiy aacieiino?eeoi?ii? aeaoa?i?iaioe i?ae i?e i?eeii? o?aaeeoe?eii? oa?ai??, aeiaeaoeiaee oa?aiaaoe/iee aoaeo aeyaeyany a a?eueo aeeiai?/iiio cieaeaii? aeoeaiino? AO-1, IOA, a oaeiae oeAIO, EE, EA ia 5-oo ? 10-oo aeiao e?eoaiiy, ui ni?eyoeeai a?aeaeaa?oueny ia i?ioeanao ?aiiaeaethaaiiy e?aiai oeoii/ea. I?iaaaeaia aeine?aeaeaiiy iieacaei, ui iaea?eueoith oi/eith i?eeeaaeaiiy ?AIO ? eae?e?a?i-e?i?iiaa nenoaia oa ca’ycaia c iath NO/oeAIO nenoaia. Iaie oaeiae aoei aea/aii aeeiai?eo iae?iaoii?aeueieo ia?aiao??a aeoeaiino? aiaeioae?th noaeei o a?oiao oai?eo, ye? io?eioaaee ?AIO o eiia?iaoe?? c aaoa-aeieaoi?aie, oa nai? aaoa-aeieaoi?e (oaa. 3). Oaaeeoea 3 Cia/aiiy aeoeaiino? iae?iaoii?aeueieo iieaciee?a noaeeiiiai oiiono o oai?eo ia ?I o i?ioean? e?eoaaiiy ?AIO (M + m) Iieaciee Aei e?eoaaiiy 5-a aeiaa 10-a aeiaa ?AIO ?AIO+aaoa-aeieaoi?e ?AIO ?AIO+aaoa-aeieaoi?e 1. AO-1 ia/ie 2. oeAIO iiieue/e 3. IOA ieiieue/e 4. EA iaae/ie 5. EE iaae/ie 18.8+0.7 20.2+0.7 48.4+0.2 156.8+9.7 169.6+7.7 15.9+0.8* 12.6+0.9* 47.5+0.2* 120.9+8.6* 153.6+7.9 20.3+1.0# 15.1+1.4* 46.0+0.2*# 63.7+7.2*# 117.7+8.7*# 14.6+0.7* 10.3+0.7* 47.0+0.2* 97.9+8.4* 139.9+7.2* 19.7+0.6# 15.3+1.1*# 45.9+0.2*# 75.2+6.3*# 75.3+6.4*# I?ei?oee: *- ?ic??ciaiiy a??ia?aei? (p<0.05) a ii??aiyii? c iieacieeaie aei e?eoaaiiy # - ?ic??ciaiiy a??ia?aei? (p<0.05) i?ae a?oiaie. Oae, yeui oa?ai?y ?AIO aeeeeeaea a??ia?aeia cieaeaiiy ??aiy AO-1 ia 5-o oa 10-o aeiao, oi i?e eiia?iaoe?? c aaoa-aeieaoi?aie ia a?aei?/aii nooo?aiai cieaeaiiy AO-1 a ii??aiyii? c aeaieie, io?eiaieie aei e?eoaaiiy. I?ae aieeaii oa?ai?? ?AIO niinoa??aa?oueny oaeiae cia/ia cieaeaiiy aeoeaiino? oeAIO ia 5-o oa 10-o aeiao e?eoaaiiy. O a?aeiioaii? IOAa EA ? EE, iii?/aiee iioaioe?thth/ee oa?aiaaoe/iee aoaeo eiia?iiaaii? oa?ai??, ui aeyaey?oueny o a??ia?aeiiio ?o cieaeaii? ia 5-o oa 10-o aeiao e?eoaaiiy. Aa?o/e aei oaaae oie oaeo , ui AO-1 ? oeAIO iaeaaeaoue aei i?noeaaeo, a IOA, EA ? EE ia?aaaaeii aei caaaeueieo oaeoi??a ?aaoeyoe?? noaeeiiiai oiiono, iiaeia c?iaeoe aeniiaie, ui aaoa-aeieaoi?e iineaaeththoue i?noeaa? oa iineeththoue caaaeuei? iaoai?cie aaci?aeaenaoe?? ?AIO. Oaeei /eiii, i?e aeii?ioaaii? aeoeaiino? i?noeaaeo iaoai?ci?a aaci?aeaenaoe?? iaae caaaeueieie iaiao?aeii i?ecia/aoe ?AIO ia oii? aacenii? oa?ai?? aac canoinoaaiiy aaoa-aeieaoi??a, a i?e aeii?ioaaii? aeoeaiino? caaaeueieo iaoai?ci?a - eiia?iiaaio oa?ai?th, aeeth/ath/o ?AIO oa aaoa-aeieaoi?e. I?iaaaeaiee nenoaiiee aiae?c iieacaa (iae. 1), ui i?e ?icaeoeo aino?iai ?I A A A A - aei e?eoaaiiy; A - 5-a aeiaa e?eoaaiiy; A - 10-a aeiaa e?eoaaiiy 1 aiaeioae?i-1 2 oeeee?/iee aoaiiceiiiiioinoao 3 iao??eo?aoe/iee ai?iii 4 eae?e?a?iiaai 5 eae?e?a?i 6 aeai?iai?iio?ainoa?aca 7 ania?oaoai?iio?ainoa?aca 8 oeoei? e?ia? Iae. 1. Ei?aeyoe?eia no?oeoo?a iieaciee?a iae?iaoii?aeueiiai noaoono noaeeiiiai oiiono oa aeoeaiino? iaoieia?/iiai i?ioeano o oai?eo ia aino?ee ?I aei oa ia oii? e?eoaaiiy ?AIO. a?aeaoaa?oueny i?aeoe/ii iiaiee ?iciaae ca’yce?a i?ae iae?iaoii?aeueieie ia?aiao?aie, ui na?ae/eoue i?i e?eco ooieoe?iioaaiiy nenoaie, iia’ycaio c aeniaaeaiiyi eiiiainaoi?ieo iaoai?ci?a ? ooieoe?iioaaiiy ?? eeoa ca ?aooiie caeo/aiiy i?aenenoaiieo ei?aeyoe?e. Ia 5-o aeiao e?eoaaiiy ?AIO a?aeaoaa?oueny ??cea iineaaeaiiy ?ioaa?aoe?? ei?aeyoe?eii? no?oeoo?e. Ia oeueiio oii? iii?/a?oueny, a?eueo i?ae a o?e ?ace, o ii??aiyii? c aeo?aeieie aeaieie, iineeaiiy aioo??oiueinenoaiii? neio?ii?caoe?? iieaciee?a oa iineaaeaiiy i?aenenoaiii? ?ioaa?aoe??. Oea na?ae/eoue i?i iineaaeaiiy ooieoe?iiaeueii? iai?oae nenoaie oa ia?ao?ae ?? c oace e?eoe/iiai ooieoe?iioaaiiy o oaco aeii?ioaaiiy eiiiainaoi?ieo iaoai?ci?a. Ia 10-o aeiao e?eoaaiiy ?AIO i?iaeiaaeo?oueny iiaeaeueoa ciaioaiiy caaaeueii? e?eueeino? ca’yce?a no?oeoo?e. Oaeei /eiii, iai?ee?ioe? eo?no oa?ai?? a?aeaoaa?oueny iaea?eueoa iineaaeaiiy ooieoe?iiaeueii? iai?oae nenoaie, c i?aeoe/ii iiaiei ii?ooaiiyi i?aenenoaiieo ca’yce?a iae?iaoii?aeueieo iieaciee?a c ia?aiao?aie iaoiaaiaoe/ii? aeaoa?i?iaioe. ?acii c e?euee?nieie ci?iaie oaeiae a?aeaoaaeany cia/ia ye?nia ia?aaoaeiaa oa?aeoa?o ei?aeyoe?e. sseui ia 5-o aeiao "ii?o?aoia" ??cieoey ei?aeyoe?eieo no?oeoo?, o ii??aiyii? c ii/aoeiaeie aeaieie, neeaaeaea 75%, oi ia 10-o aeiao aiia aeinyaaea iaeneiaeueii? aaee/eie - 88.2%. Oaeei /eiii, iai?ee?ioe? eo?no oa?ai?? a?aeaoaa?oueny iaea?eueoa ia?aaoaeiaa a?o?oaeoii?ee ooieoe?iiaeueii? nenoaie, eio?a neeaeany a ia?oo aeiao caoai?thaaiiy. Ii??aiyiiy nenoaiiiai aoaeoo canoinoaaiiy ?AIO oa o?aaeeoe?eii? oa?ai?? iieacaee (Iae. 2), ui i?e o?aaeeoe?ei?e oa?ai?? iii?/athoueny ae? ae nai? nenoaii? i?ioeane, aea nooi?iue ?o aeyaeaiue cia/ii iinooia?oueny aoaeoai, i?e e?eoaaii? ?AIO. A A A A - aei e?eoaaiiy; A - 5-a aeiaa e?eoaaiiy; A - 10-a aeiaa e?eoaaiiy Iae. 2. Ei?aeyoe?eia no?oeoo?a iieaciee?a iae?iaoii?aeueiiai noaoono noaeeiiiai oiiono oa aeoeaiino? iaoieia?/iiai i?ioeano o oai?eo ia aino?ee ?I aei oa ia oii? e?eoaaiiy o?aaeeoe?eiith oa?ai??th. Oae, caaaeueia e?euee?noue ca’yce?a no?oeoo?e ia 5-o aeiao oa?ai?? i?e o?aaeeoe?eiiio e?eoaaii? ia?aaeuo? oaeee aea iieaciee o oai?eo, ye? io?eioaaee ?AIO ia 10%, e?euee?noue i?aenenoaiieo ei?aeyoe?e a?aeiia?aeii ia 133%, a e?euee?noue aioo??oiueinenoaiieo ei?aeyoe?e, iaaiaee, aoea aeua ia 100% a a?oi? oai?eo, ui io?eioaaee ?AIO. Oaeei /eiii, iaea?eueo? ?ic??ciaiiy i?ae a?oiaie oi?eoeeny ia caaaeueii? e?eueeino? aai o?niioe ca’yce?a, a ?o aioo??oiueinenoaiii? aai i?aenenoaiii? ?ioaa?aoe??. Iniaeeai oea a?aeaeeiny ia iieacieeo ni?aa?aeiioaiiy e?eueeino? aioo??oiueinenoaiieo oa i?aenenoaiieo ca’yce?a. O a?oi? oai?eo, ui i?eeiaee ?AIO, eiao?oe??io aeii?ioaaiiy aioo??oiueinenoaiieo ca’yce?a iaae i?aenenoaiieie ia?aaeuoaaa oaeee o a?oi? oai?eo, ye? io?eioaaee o?aaeeoe?eio oa?ai?th a 4 ?ace, ui na?ae/eoue i?i aeoaea cia/ia cieaeaiiy ooieoe?iiaeueii? iai?oae nenoaie iae?iaoii?aeueii? ?aaoeyoe?? noaeeiiiai oiiono i?ae aieeaii ?AIO a ii??aiyii? ?c canoinoaaiiyi o?aaeeoe?eii? oa?ai??. Iai?ee?ioe? eo?no e?eoaaiiy a a?oi? oai?eo, ui io?eioaaee caaaeueiicanoiniaaia e?eoaaiiy, o ii??aiyii? c oai?eie, ye? io?eioaaee aeiaeaoeiai ?AIO, aeyaeaii iineeaiiy caaaeueii? ?ioaa?aoe?? ei?aeyoe?eii? no?oeoo?e ia 25%, a i?aenenoaiii? ?ioaa?aoe?? ia 100%. Aioo??oiueinenoaiia ?ioaa?aoe?y iieaciee?a ooieoe?iiaeueii? nenoaie, iaaiaee, aoea aeua ia 20% o oai?eo, ye? io?eioaaee ?AIO. Oaeei /eiii, i?e o?aaeeoe?eiiio e?eoaaii? a?aecia/a?oueny a?eueo oi?i?aeia, i?ae i?e aeei?enoaii? ?AIO, aeeiai?ea a?aeiiaeaiiy ooieoe?iiaeueieo aeanoeainoae nenoaie iae?iaoii?aeueieo iieaciee?a noaeeiiiai oiiono, ui i?aeoaa?aeaeothoue oae? cia/i? a?aei?iiino? a oa?aeoa?enoeeao ooieoe?iioaaiiy, ?icaeyiooi? nenoaie i?aai?cio ia 10-oo aeiao caoai?thaaiiy. Aoaeoeaia ii?iae?caoe?y ca aeiiiiiaith ?AIO on?o oa?aeoa?enoee ooieoe?iiaeueii? nenoaie, o naith /a?ao aeicaiey? ?e i?eai?/oaaoe iaoieia?/io aeaoa?i?iaioo, a iio?i aeaaaoe ni?iiiaei?noue aeey aoaeoeaiiai ?aiiaeaethaaiiy i?iea?aeo. Oaeei /eiii, i?iaaaeaiee nenoaiiee aiae?c aeyaea aeiaeaoeiaee nenoaiiee aoaeo ?AIO, o ii??aiyii? c o?aaeeoe?eiei e?eoaaiiyi, yeee iieyaa? a cieaeaii? ooieoe?iiaeueii? iai?oae nenoaie oa i?aeaeuaii? ?? eiiiainaoi?ieo iiaeeeainoae. Aa?o/e aei oaaae, ui aei o?aaeeoe?eii? oa?ai?? o cia/i?e e?eueeino? ianoaaeaieo oai?eo aoea canoiniaaia o?iiaie?oe/ia oa?ai?y, a oaeiae canoiniaoaaany i?eeii aaoa-aeieaoi??a, ie aea/aee aieea ia ia?aa?a aino?iai ?I ??ciiiai?oieo aa??aio?a oa?ai?? a caeaaeiino? a?ae ?icaeoeo a i?ioean? e?eoaaiiy oneeaaeiaiue (Iae.3) /anoioa oneeaaeiaiue aino?iai ?I acaaae? ii an?e a?oi? oai?eo *- p<0.05 a ii??aiyii? c caaaeueiith /anoioith oneeaaeiaiue O – o?iiaie?oeee; b – aaoa-aeieaoi?e; e - ?AIO Iae. 3. Aieea ??ciiiai?oieo aa??aio?a oa?ai?? ia /anoioo oneeaaeiaiue aino?iai ?I. I?iaaaeai? aeine?aeaeaiiy iieacaee, ui iaea?eueo aoaeoeaiei iaoiaeii e?eoaaiiy aino?iai ?I, uiaei ?icaeoeo oneeaaeiaiue, ? ii?aeiaia canoinoaaiiy o?iiaie?oe/ii? oa?ai?? oa ?AIO. I?ecia/aiiy aaoa-aeieaoi??a oa ?AIO ia? aooe aeeoa?aioe?eiaaiei. Iaeiei ?c e?eoa???a ?iaeea?aeoae?caoe?? i?ecia/aiiy aaoa-aeieaoi??a a eiia?iaoe?? c ?AIO, ? ni?aa?aeiioaiiy aeoeaaoe?? oeaio?aeueieo (IOA, EA, EE) oa i?noeaaeo (AO-1, oeAIO) oaeoi??a ?aaoeyoe?? noaeeiiiai oiiono. I?e aeii?ioaaii? i?noeaaeo iaoai?ci?a aaci?aeaenaoe?? iaae oeaio?aeueieie iaiao?aeii i?ecia/aoe ?AIO aac aaoa-aeieaoi??a, a i?e aeii?ioaaii? aeoeaiino? oeaio?aeueieo iaoai?ci?a – eiia?iiaaio oa?ai?th ?AIO ? aaoa-aeieaoi?e. Iaiao?aeii oaeiae caa?iooe oaaao ia iaaeinoaoith aoaeoeai?noue eiia?iaoe?? ?AIO oa aaoa-aeieaoi??a aac canoinoaaiiy nenoaiiiai o?iiaie?c?no a e?eoaaii? ?I, i?e ye?e niinoa??aaeiny cia/ia i?aeaeuaiiy e?eueeino? oneeaaeiaiue (86%), ui a?eueoa i?ae a o?e ?ace ia?aaeuoaaei ??aaiue oneeaaeiaiue i?e canoinoaaii? o?iiaie?oee?a oa ?AIO (25%). Aea/aiiy i?iaiinoe/ii? cia/ouino? iae?iaoii?aeueieo oaeoi??a ?aaoeyoe?? noaeeiiiai oiiono o oai?eo ?I uiaei ?icaeoeo oneeaaeiaiue a aino?iio ia??iae? caoai?thaaiiy iieacaei (Iae. 4), ui iaea?eueoo cia/ou?noue ia? iai?yi aeeiai?ee EE ia 5-o aeiao oa AEO ia 10-o aeiao e?eoaaiiy. Iae. 4. ?icoaooaaiiy iae?iaoii?aeueieo oaeoi??a ?aaoeyoe?? noaeeiiiai oiiono o oai?eo ia aino?ee ?I ca i?iaiinoe/iith cia/ou?noth (t-e?eoa??e) Iaeiae canoiniaai? aeaee oa?ai?? (o?iiaie?oeee, ?AIO oa aaoa-aeieaoi?e) iaee ye iiceoeaiee, oae ? iaaaoeaiee aieea ia aieiai? iaoiaaiaoe/i? iaoai?cie, eio?? iia’ycai? c aeieeiaiiyi oneeaaeiaiiai ia?aa?ao aino?iai ?I. Aa?o/e oea aei oaaae, iiaeia c?iaeoe aeniiaie, ui iaaeeeaiaioicia e?eoaaiiy aino?iai ?I ia? aooe noai?i aeeoa?aioe?eiaaiei. O ca’yceo c oeei iaie aoee ?ic?iaeaii aeai?eoie aeey iai?yiiai aecia/aiiy aeeiai?ee iae?iaoii?aeueieo oaeoi??a noaeeiiiai aiiainoaco AO-1, oeAIO, EE, i?iaiinoe/i? iiaeae? aeey aecia/aiiy aeeiai?ee AEO ia 10oo oa EE ia 5oo aeiao ?I, a oaeiae iiaeaeue i?iaiicoaaiiy oneeaaeiaiiai oa iaoneeaaeiaiiai ia?aa?ao aino?iai ?I, ui aeaei iai ciiao ia oe?e iniia? ?ic?iaeoe ocaaaeueiaiee aeai?eoi ?iaeea?aeoae?ciaaii? oa?ai?? oai?eo ia aino?ee ?I (Iae. 5.). EE5 – ??aaiue ee?e?a?io ia 5-oo aeiao caoai?thaaiiy AEO10 – ??aaiue aeai?iai?iio?ainoa?ace ia 10-oo aeiao caoai?thaaiiy Iae. 5. Aeai?eoi aeai?o ?iaeea?aeoaeueii-ni?yiiaaii? oa?ai?? aeey oai?eo ia aino?ee ?I Aeniiaee Aeey oai?eo ia aino?ee ?I ?icaeoie aiaeioae?aeueii? aeenooieoe?? aeyaey?oueny ye o i?aeaeuaii? ai?noo aacieiino??eoi?a aiaeioae?io-1, oae ? i?aeaeuaiiyi aeoeaiino? aaci?aeaenoth/iai ieneaeo acioo. O caeaaeiino? a?ae ia’?io ina?aaeeo o?aaeaiiy , a?aei?/a?oueny ??cieoey a aeii?ioaaii? aacieiino??eoi?ieo ? aaciae?eyooth/eo oaeoi??a noaeeiiiai aiaeino??eoi??a, ui ? iaei??th c oa?aeoa?ieo iciae ia?oi? aeiae caoai?thaaiiy. I?e canoinoaaii? ?AIO a?aeaoaa?oueny a?eueo aeeiai?/ia , i?ae i?e aaceniiio e?eoaaii?, ei?aeoe?y iae?iaoii?aeueieo iaoai?ci?a ?aaoeyoe?? noaeeiiiai oiiono, yea aeyaey?oueny a ii?iae?caoe?? ni?aa?aeiioaiiy i?ae aiaeioae?aeueieie aacieiino??eoi?ieie oa aaciae?eyooth/eie oaeoi?aie. I?eeii ?AIO c ia?oi? aeiae ?I ia? ni?eyoeeao ae?th ia ee?i?/iee ia?aa?a caoai?thaaiiy oa aioo??oiueina?oeaao aaiiaeeiai?eo, oiia?eueith? i?ia?anoaaiiy aeeeyoaoe?? e?aiai oeoii/ea oa cia/ii ciaioo? i?iya na?oeaai? iaaeinoaoiino?. Iaea?eueo aeioe?eueiee i?eeii ?AIO, aeey oai?eo ?I, i?e iayaiino? i?aeaeuaiiai oa aenieiai a?oa??aeueiiai oeneo oa ?icaeoeo na?oeaai? iaaeinoaoiino?. I?e niieo/aiiio i?eeii? aaoa-aeieaoi??a oa ?AIO a?aei?/a?oueny ??ciini?yiiaai?noue iiaeoethth/iai aieeao aaoa-aeieaoi??a ca ?aooiie iineaaeaiiy i?noeaaeo oa iineeaiiy caaaeueieo iaoai?ci?a aaci?aeaenaoe?? ?AIO. Aoaeo ?AIO ia aiaeioae?eio ooieoe?th ?aae?co?oueny oeyoii aieeao ia aeoeai?noue eae?e?a?i-e?i?iiai? nenoaie, eio?a iin?aaeo? aieea ?AIO ia aiaeioae?ei? oaeoi?e ?aaoeyoe?? noaeeiiiai aiiainoaco. I?ae aieeaii ?AIO a nenoai? aiaeioae?eii? ?aaoeyoe?? noaeeiiiai oiiono aeyaeaii cia/io ia?aaoaeiao ei?aeyoe?eieo no?oeoo?, yea a?aeia?aaea?oueny a cieaeaii? i?aenenoaiii? oa i?aeaeuaii? aioo??oiueinenoaiii? ?ioaa?aoe?? iieaciee?a, ui na?ae/eoue i?i ciaioaiiy ooieoe?iiaeueii? iai?oae nenoaie ? oi?ioaaii? ye?nii iiai? ooieoe?iiaeueii? nenoaie, ui ia? a?eueo cia/i? eiiiainaoi?i? aeanoeaino?. Iaea?eueo aoaeoeaiei iaoiaeii e?eoaaiiy ?I, ? niieo/aia canoinoaaiiy nenoaiii? o?iiaie?oe/ii? oa?ai?? oa i?ecia/aiiy ?AIO c ia?oi? aeiae e?eoaaiiy. Iaaeinoaoiith ? eiia?iaoe?y e?ea?nueeeo cania?a - i?ecia/aiiy ?AIO oa aaoa-aeieaoi??a aac o?iiaie?oe/ii? oa?ai??. ?ic?iaeai? ca aeiiiiiaith aiae?oe/iiai i?aeoiaeo oa nenoaiiiai aiae?co caeiiii??iino? noaio iae?iaoii?aeueieo iaoai?ci?a ?aaoeyoe?? noaeeiiiai oiiono oa aeeiai?ee a i?ioean? oa?ai?? aino?iai ?I, aeicaieeee ?ic?iaeoe ??ciiiai?oi? i?iaiinoe/i? iiaeae? aeey ioe?iee iniaeeainoae ia?aa?ao aino?iai ?I ? ia oe?e iniia? caoaeoaaoe caaaeueiee aeai?eoi ?iaeea?aeoae?ciaaii? oa?ai?? oai?eo ia aino?ee ?I. I?aeoe/i? ?aeiiaiaeaoe?? Aeyaeaia aeeiai?ea aiaeioae?aeueieo oaeoi??a ?aaoeyoe?? noaeeiiiai oiiono i?ae aieeaii iaaeeeaiaioicii? oa?ai?? ?AIO aeeeoo? iaiao?aei?noue aeeoa?aioe?eiaaiiai i?ecia/aiiy e?ea?nueeeo cania?a, ye? aeei?enoiaothoueny i?e e?eoaaii? ?I, ?c canoinoaaiiyi cai?iiiiiaaieo aeai?eoi?a ?iaeea?aeoae?ciaaiiai e?eoaaiiy ?I. Aeyaeaia ii?ooaiiy aoii?aeueiiai niaeo?o e?ia? i?e ?I, iniaeeai i?e i?ia?anoaaii? na?oeaai? iaaeinoaoiino? oa ?icaeoeo oneeaaeiaiue, aeiaiaeeoue aeioe?euei?noue canoinoaaiiy iaaeeeaiaioicieo i?aia?ao?a, ae?y yeeo ni?yiiaaia ia ei?aeoe?th oeeo ii?ooaiue. Iaei??th c oaeeo eiia?iaoe?e ? canoinoaaiiy nenoaiii? o?iiaie?oe/ii? oa?ai?? ? ?AIO c ia?oi? aeiae caoai?thaaiiy. Aeeth/aiiy ?AIO o noaie e?eoaaiiy aino?iai ?I c ia?oi? aeiae caoai?thaaiiy ?aeiiaiaeo?oueny ye oai?ei c iaoneeaaeiaiei ia?aa?aii caoai?thaaiiy, oae ? oneeaaeiaiei, iniaeeai o aeiaaeeao i?aeaeuaieo oeeo? a?oa??aeueiiai oeneo ? ?icaeoeii iciae iaaeinoaoiino? e?iaiia?ao. Aaaaea?oueny iaaeioe?eueiei aeei?enoaiiy a e?eoaaii? aino?iai ?I eiia?iaoe?? ?AIO oa aaoa-aeieaoi??a aac canoinoaaiiy o?iiaie?oe/ii? oa?ai??, o ca’yceo c oa?aiaaoe/iith iaaeinoaoi?noth: aenieee ?ecee ?icaeoeo oneeaaeiaiue, ye? noi?iaiaeaeothoue ia?aa?a aino?iai ia??iaeo ?I. Nienie iaoeiaeo i?aoeue Eaoee A.E. "NO - oeAIO nenoaia o aieueiuo ino?ui eioa?eoii ieiea?aea" // «Nia?aiaiiua i?iaeaiu eeeieee aioo?aiieo aieaciae». Nai?iee iao/iuo o?oaeia e 120-eaoeth eaoaae?u ainieoaeueiie oa?aiee OAIO.- Oa?ueeia: - 1997.- N. 146-151. Eaoee A.E. "NO/oeAIO nenoaia a ino?ii ia?eiaea eioa?eoa ieiea?aea" // I iaaeaeoia?iaeiue iaaeeoeeineee eiia?ann nooaeaioia e iieiaeuo o/aiuo. 18 – 22 iay 1997a. a. Oa?iiiieue. Oe?aeia. – N. 120 – 121. Letik V. I. "NATRIURETIC HORMONE and Na-K-ATP ACTIVITY IN PATIENT WITH ACUTE MYOCARDIAL INFARCTION" // 8th European Conference of the Charite, Berlin, Germany. October 15th – 18th 1997. Abstract N 65, p.69. Letik V. I. “Endothelin-1 in patients with Acute Myocardial Infarction“ // 9th European Conference of the Charite, Berlin, Germany. October 21st – 24th 1998. Abstract N 14, p.39. Eaoee A. E., Aeueoi ss. A. «Aeoeaiinoue NO/oeAIO nenoaiu i?e ino?ii eioa?eoa ieiea?aea» // Ieaioi oi?aaeaiey iao/iiai iauanoaa ea?aeeieiaia Oe?aeiu iinayuaiiue iaiyoe E.E. Ieoiaaa, I.A. Aaaooa e I.E. A?eoethea. "Aoa?ineea?ic e eoaie/aneay aieaciue na?oea: nia?aiaiiua aniaeou i?ioeeaeoeee, aeeaaiinoeee, ea/aiey". 11 - 13 iiya?y 1998a. Oe?. IEE ea?aeeieiaee ei. No?aaeanea, Eeaa, Oe?aeia.- N. 9. Eao?e A.?. «Aeoeai?noue NO/oeAIO nenoaie o oai?eo ia aino?ee ?ioa?eo i?iea?aeo c Q coaoeai oa aac iueiai” // E?ee. - 1998. - ? 5. - N. 96 - 98. Eaoee A.E. "Na-K-AOO-aciay aeoeaiinoue e niaea?aeaiea iao?eeo?aoe/aneiai ai?iiia a ino?ii ia?eiaea eioa?eoa ieiea?aea" // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. - 1998. - ? 23. - N. 39-44. Eaoee A.E. Iaci?. "Nia?aiaiiua i?aaenoaaeaiey i ?aiei-aiaeioaiceiiaie nenoaia e aiciiaeiuo niiniaao iiaeaaeaiey aa aeoeaiinoe" // A?a/aaiay i?aeoeea. – 1999. - ? 1. - N. 67 –70. Eaoee A.E. "Aiciiaeiinoue ii?aaeaeaiey o?iaiy yiaeioaeeia -1 o aieueiuo ino?ui eioa?eoii ieiea?aea n eniieueciaaieai ?ooeiiuo eeeie/aneeo e eaai?aoi?iuo enneaaeiaaiee" // A?a/aaiay i?aeoeea. - 1999. - ? 2. - N. 77 - 81. Eaoee A.E. «Nenoaiiue aiaeec yooaeoeaiinoe i?eiaiaiey eiaeaeoi?ia AIO i?e ino?ii eioa?eoa ieiea?aea» // ?anioaeeeaineay iao/ii-i?aeoe/aneay eiioa?aioeey iieiaeuo o/aiuo, 15 ethiy 1999 a. EO AIIO, a. Oa?ueeia. «Ia?niaeoeau ?acaeoey oa?aiee a eaioi OOI aaea». N. 39-40. Aiioaoe?y Eao?e A.?. Aeoeai?noue aiaeioae?io-1 oa ieneaeo acioo o oai?eo ia aino?ee ?ioa?eo i?iea?aeo a aeeiai?oe? e?eoaaiiy ?ia?a?oi?aie aia?ioaicei-ia?aoai?thth/iai oa?iaioo. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.11 - ea?ae?ieia?y. - Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?y i?enay/aia aea/aiith ?ie? aoii?aeueieo ii?ooaiue noaeeiiiai aiaeioae?th i?e aino?iio ?ioa?eo? i?iea?aeo a caeaaeiino? a?ae ee?i?/iiai ia?aa?ao, a oaeiae ioe?ioe? ee?i?/ii? aoaeoeaiino? ?o ei?aeoe?? ?ia?a?oi?aie AIO. Ca aeiiiiiaith oaeoi?iiai oa nenoaiiiai aiae?co ?ic?iaeaii ??ciiiai?oi? i?iaiinoe/i? iiaeae? aeey ioe?iee iniaeeainoae ia?aa?ao aino?iai ?I oa iiaoaeiaaii caaaeueiee aeai?eoi ?iaeea?aeoae?ciaaii? oa?ai?? oai?eo ia aino?ee ?I. Aeiaaaeaii, ui aiaeioae?aeueia aeenooieoe?y ? iaeiei ?c oaeoi??a ?icaeoeo aino?iai ?I. O caeaaeiino? a?ae ia’?io ona?aaeeo o?aaeaiiy , a?aei?/a?oueny ??cieoey a aeii?ioaaii? aacieiino??eoi?ieo ? aaciae?eyooth/eo oaeoi??a noaeeiiiai aiaeioae?th: i?e o?ainio?aeueiiio ?I - aaciae?eyoaoi??a, i?e ae??aiiaiaiaaiio ?I – aacieiino??eoi??a. Anoaiiaeaii, ui aeiaeaoeiaa i?ecia/aiiy ?ia?a?oi??a AIO aeeeeea? cia/io ia?aaoaeiao ooieoe?iiaeueii? nenoai? i?aai?cio, yea ae?aaea?oueny a cieaeaii? i?aenenoaiii? oa i?aeaeuaii? aioo??oiueinenoaiii? ?ioaa?aoe?? aiaeioae?aeueieo oaeoi??a, ui na?ae/eoue i?i ciaioaiiy ooieoe?iiaeueii? iai?oae nenoaie ? oi?ioaaii? ye?nii iiai? ooieoe?iiaeueii? nenoaie, aieiae?th/i? a?eueo cia/ieie eiiiainaoi?ieie aeanoeainoyie. Iaea?eueo aoaeoeaiei iaoiaeii e?eoaaiiy ?I, ? noi?nia canoinoaaiiy nenoaiii? o?iiaie?oe/ii? oa?ai?? oa i?ecia/aiiy ?AIO c ia?oi? aeiae e?eoaaiiy. Eiia?iaoe?y ?AIO oa aaoa-aeieaoi??a aac o?iiaie?oe/ii? oa?ai?? ? iaaeinoaoiuei aoaeoeaiith ye i?e oneeaaeiaiiio oa ? i?e iaoneeaaeiaiiio ia?aa?ao ?I. Eeth/ia? neiaa: ?ia?a?oi?e AIO, aino?ee ?ioa?eo i?iea?aeo, aiaeioae?aeueia aeenooieoe?y, aiaeioae?i-1, ieneae acioo, oeeee?/i? ioeeaioeaee, eae?e?a?iiaai, eae?e?a?i. Aiiioaoeey Eaoee A.E. Aeoeaiinoue yiaeioaeeia-1 e ieene acioa o aieueiuo ino?ui eioa?eoii ieiea?aea a aeeiaieea ea/aiey eiaeaeoi?aie aiaeioaicei-i?aa?auathuaai oa?iaioa. – ?oeiienue. aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.11 - ea?aeeieiaey. - Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Aeenna?oaoeey iinayuaia aii?inai eco/aiey ?iee aoii?aeueiuo ia?ooaiee ninoaeenoiai yiaeioaeey i?e ino?ii eioa?eoa ieiea?aea a caaeneiinoe io oyaeanoe eeeie/aneiai oa/aiey, a oaeaea ioeaiea eeeie/aneie yooaeoeaiinoe eo ei??aeoeee eiaeaeoi?aie AIO. Aeey ?aoaiey iinoaaeaiiuo caaea/ ianeaaeiaaii 122 aieueiuo eioa?eoii ieiea?aea a ino?ii ia?eiaea caaieaaaiey. Aue eniieueciaai eiiieaen iaoiaeee (?aaeeieioiiue, eiioiioa?iaioiue, niaeo?ioioiiao?e/aneee) ?ac?aaioaiiuo aeey ?aaeno?aoeee aaciaeoeaiuo aoii?aeueiuo oaeoi?ia aacieiino?eeoeee (yiaeioaeei-1, aeiioaeaie/aneee iao?eeo?aoe/aneee ai?iii, aeoeaiinoue Na-K-AOOacu y?eo?ioeeoia) e aaci?aeaenaoeee (oeAIO, eaeeee?aeiiaai, eaeeee?aei), a ieacia e?iae, eioi?ua a?aee i?e iinooieaiee a noaoeeiia? e iiaoi?yee /a?ac 24 /ana, ia iyoua e aeanyoua nooee caaieaaaiey. Aieueiua ino?ui eioa?eoii ieiea?aea ianeaaeiaaiu n i?eiaiaieai iaoiaeia: YEA a iieia a 12-oe noaiaea?oiuo ioaaaeaieyo, Yoi ea?aeeia?aoee, Ro- enneaaeiaaiey i?aaiia a?oaeiie eeaoee. Aiaeec iieo/aiiuo aeaiiuo i?iaiaeeeny n iiiiuueth oaeoi?iiai aiaeeca. Nenoaiiue aiaeec eco/aaiuo iieacaoaeae i?iaiaeeeny iaoiaeii ei??aeyoeeiiiuo no?oeoo?. Enneaaeiaaiey iieacaee, /oi o aieueiuo ino?ui EI ?acaeoea yiaeioaeeaeueiie aeenooieoeee i?iyaeyaony eae a oaaee/aiee niaea?aeaiey eco/aaiuo aacieiino?eeoi?iuo oae e aaciaeeeyoe?othueo oaeoi?ia. Aeieacaii, /oi yiaeioaeeaeueiay aeenooieoeey yaeyaony iaeiei ec oaeoi?ia ?acaeoey ino?iai eioa?eoa ieiea?aea. A caaeneiinoe io iauaia i/aaa ii?aaeaiey, ioia/aaony ?acieoea a aeiieie?iaaiee aacieiino?eeoi?iuo e aaciaeeeyoe?othueo oaeoi?ia ninoaeenoiai yiaeioaeey: i?e o?ainio?aeueiii eioa?eoa ieiea?aea - aaciaeeeyoaoi?ia, i?e iaeeii/aaiaii - aacieiino?eeoi?ia. Aiaeec yooaeoeaiinoe i?eiaiaiey eiaeaeoi?ia AIO a ino?ii ia?eiaea eioa?eoa ieiea?aea iieacae, /oi i?e eniieueciaaiee aeaiiie a?oiiu i?aia?aoia i?ienoiaeeo aieaa aeeiaie/iay, /ai i?e o?aaeeoeeiiiie oa?aiee ei??aeoeey iae?iaoii?aeueiuo iaoaieciia ?aaoeyoeee ninoaeenoiai oiiona, i?iyaeythuayny a ii?iaeecaoeee niioiioaiey iaaeaeo yiaeioaeeaeueiuie aacieiino?eeoi?iuie e aaciaeeeyoe?othueie oaeoi?aie. Ia iniiaa eco/aiey aeaiiuo oeaio?aeueiie aaiiaeeiaieee e aiaeeca YOI ea?aeeia?aoe/aneeo enneaaeiaaiee onoaiiaeaii, /oi i?eai eiaeaeoi?ia AIO n ia?auo nooie ino?iai eioa?eoa ieiea?aea ieacuaaao aeaaii?eyoiia aeeyiea ia eeeie/aneia oa/aiea caaieaaaiey e aioo?ena?aea/ioth aaiiaeeiaieeo, caiaaeeyao i?ia?anne?iaaiea aeeeyoaoeee eaaiai aeaeoaei/ea e cia/eoaeueii oiaiueoaao i?iyaeaiey na?aea/iie iaaeinoaoi/iinoe. Yoi iicaieeei naeaeaoue auaiae i iaeaieaa oeaeaniia?aciii i?eai eiaeaeoi?ia AIO o aieueiuo n eioa?eoii ieiea?aea, i?e iaee/ee oaaee/aiiiai eee aunieiai a?oa?eaeueiiai aeaaeaiey e i?eciaeia na?aea/iie iaaeinoaoi/iinoe. Nenoaiiue aiaeec iicaieee onoaiiaeoue, /oi aeiiieieoaeueiia iacia/aiea eiaeaeoi?ia AIO, n ia?auo nooie eioa?eoa ieiea?aea, aucuaaao cia/eoaeueioth ia?ano?ieeo ooieoeeiiaeueiie nenoaiu i?aaiecia, eioi?ay au?aaeaaony a nieaeaiee iaaenenoaiiie e oaaee/aiee aioo?enenoaiiie eioaa?aoeee yiaeioaeeaeueiuo oaeoi?ia aacieiino?eeoeee e aaci?aeaenaoeee, /oi naeaeaoaeuenoaoao ia oiaiueoaiee ooieoeeiiaeueiiai iai?yaeaiey nenoaiu e oi?ie?iaaiee ea/anoaaiii iiaie ooieoeeiiaeueiie nenoaiu, iaeaaeathuae aieaa au?aaeaiiuie eiiiainaoi?iuie aiciiaeiinoyie. Iieo/aiiua aeaiiua iicaieeee naeaeaoue auaiae i oii, /oi iaeaieaa yooaeoeaiui iaoiaeii ea/aiey eioa?eoa ieiea?aea, yaeyaony ni/aoaiiia i?eiaiaiea nenoaiiie o?iiaieeoe/aneie oa?aiee e iacia/aiea eiaeaeoi?ia AIO n ia?auo nooie caaieaaaiey. Eiiaeiaoeey eiaeaeoi?ia AIO e aaoa-aeieaoi?ia aac o?iiaieeoe/aneie oa?aiee yaeyaony iaaeinoaoi/ii yooaeoeaiie, eae i?e ineiaeiaiiii, oae e i?e ia ineiaeiaiiii oa/aiee eioa?eoa ieiea?aea. Eniieueciaaiea oaeoi?iiai e nenoaiiiai aiaeeca iicaieeei ?ac?aaioaoue ?acee/iua i?iaiinoe/aneea iiaeaee, i?aaenoaaeaiiua a aeaea aeai?eoiia, aeey ioeaiee iniaaiiinoae oa/aiey ino?iai eioa?eoa ieiea?aea. ?ac?aaioaiiue iaiauathuee aeai?eoi eiaeeaeaeoaeece?iaaiiie oa?aiee aieueiuo ino?ui eioa?eoii ieiea?aea /anoe/ii ?aoaao aii?inu eiaeeaeaeoaeueiinoe iiaeoiaeia a ea/aiee aeaiiiai caaieaaaiey. Eeth/aaua neiaa: eiaeaeoi?u AIO, ino?ue eioa?eo ieiea?aea, yiaeioaeeaeueiay aeenooieoeey, yiaeioaeei-1, ieenue acioa, oeeeee/aneea ioeeaioeaeu. ANNOTATION Vladislav Letik. Endothelin-1 and nitric oxide activity in patients with acute myocardial infarction in dynamics of treatment with angiotensin-converting enzyme inhibitors. - Manuscript. Thesis competing for a scientific degree of Candidate of Medical Sciences in specialty 14.01.11- Cardiology. - Kharkov State Medical University, Kharkov, 1999. The thesis deals with study of the role of humoral disturbances in the vascular endothelium in acute myocardial infarction (AMI) depending upon the clinical course, as well as with assessment of clinical efficacy of their correction by angiotensin-converting enzyme (ACE) inhibitors. With help of the factorial and systemic analysis, various prognostic models for assessing peculiarities in the course of AMI have been developed and a generalizing algorithm of individualized therapy for patients with AMI has been created. It has been proved that endothelial function is a factor of development of AMI. Depending upon the scope of the focus of lesion, these is different dominance of vasoconstricting and vasodilating factors of the vascular endothelium: in Q-wave AMI – vasodilators prevail, while in a non Q-wave AMI – vasoconstrictors do. It has been revealed that in additional administration of ACE inhibitors results in a significant reconstruction of the functional system of the organism; it is manifested by a decreased intersystemic integration of endothelial factors and an increased intrasystemic one, thereby testifying to a reduction in the functional tension of the system and formation of a qualitatively new functional system which possesses more expressed compensating abilities. A combined use of systemic trombolitic therapy and administration of ACE inhibitors from the first hours of disease are the most effective method for treating AMI. Use of ACE inhibitors and beta-blockers without any trombolitic therapy is an negative combination of medical means. Key words: ACE inhibitors, acute myocardial infarction, endothelial dysfunction, endothelin-1, nitric oxide, cyclic nucleotides. Nienie oiiaieo iicia/aiue AA - a?oa??aeueia a?ia?oaic?y AEO - aeai?iai?iio?ainoa?aca ?ON - ?oai?/ia oai?iaa na?oey ?I - ?ioa?eo i?iea?aeo ?AIO - ?ia?a?oi?e aia?ioaicei-ia?aoai?thth/iai oa?iaioo EA - eae?e?a?iiaai EE – eae?e?a?i IE – iaaeinoaoi?noue e?iaiia?ao IOA – iao??eo?aoe/iee ai?iii Na-K-AOOaca - iao??e-eae??aa-AOOaca NO - ieen acioo NO - noaiiea?ae?y NI - na?oeaaa iaaeinoaoi?noue oeAIO - oeeee?/iee 3'5'-aoaiiceiiiiioinoao AO-1 - aiaeioae?i-1 4 1 5 6 5 6 6 5 3 7 3 4 2 7 8 3 4 2 1 7 8 2 1 8 1 2 4 5 6 5 6 6 5 3 7 8 3 4 2 7 8 2 1 7 8 1 3 4

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