I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE
OE?A?INUeEEE iaoEIAI-AeINE?AeIEE ?inoeooo
aea?iaoieia?? OA aaia?ieia??
IAIAAeE? IAA?? IAIAAe IAEE
OAeE 616.972-085.334-036:616.832.9-008.849
E?eoaaiiy oai?eo ia ?aii?e neo?e?n ii?aeiaiei canoinoaaiiyi
i?iea?i-iai?oeee?io ? aaicaoei-iai?oeee?io a oaeiae
oaiien?iaoeeiai?oeee?io
(ee?i?ei-eaai?aoi?ia aeine?aeaeaiiy)
14.01.20 – oe??i? oa aaia?e/i? oai?iae
Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy
eaiaeeaeaoa iaaee/ieo iaoe
Oa?e?a – 1999
Aeena?oaoe??th ? ?oeiien.
?iaioa aeeiiaia a Oe?a?inueeiio iaoeiai-aeine?aeiiio ?inoeooo?
aea?iaoieia?? oa aaia?ieia?? IIC Oe?a?ie.
Iaoeiaee ea??aiee: – aeieoi? iaaee/ieo iaoe,
Iaa?ia Aaiiaae?e ?aaiiae/,
Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo
aea?iaoieia?? oa aaia?ieia?? IIC Oe?a?ie caa?aeoth/ee a?aeae?eii
aaia?ieia?? .
Io?oe?ei? iiiiaioe:
aeieoi? iaaee/ieo iaoe, i?ioani? ?aae?iiia Aieiaeeie? A?eai?iae/,
Eoaainueeee Aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie, caa?aeoth/ee
eaoaae?ith oe??ieo oa aaia?e/ieo oai?ia;
–eaiaeeaeao iaaee/ieo iaoe, aeioeaio, Aeoia?aa Aaeeia Ieaen??aia,
Oa?e?anueea aea?aeaaia iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe IIC
Oe?a?ie, aeioeaio eaoaae?e oe??ieo oa aaia?e/ieo oai?ia.
I?ia?aeia onoaiiaa: Oe?a?inueeee Iaoeiiiaeueiee iaaee/iee oiiaa?neoao
ii. aeaae. I.I. Aiaiiieueoey IIC Oe?a?ie, eaoaae?a oe??ieo oa aaia?e/ieo
oai?ia, i. Ee?a.
Caoeno a?aeaoaeaoueny «__27___» aeiaoiy_ 1999 ?. i __12____ aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.603.01 i?e Oe?a?inueeiio
iaoeiai-aeineiaeiiio iinoeoooi aea?iaoieiai? oa aaia?ieiai? ca
aae?anith: 310057, i.Oa?eia, aoe. *a?ieoaanueeiai 7/9.
C aeena?oaoei?th iiaeia iciaeiieoeny a aiaeiioaoei Oe?a?inueeiai
iaoeiai-aeineiaeiiai iinoeoooo aea?iaoieiai? oa aaia?ieiai? (i.Oa?eia,
aoe. *a?ieoaanueeiai 7/9).
Aaoi?aoa?ao ?icineaiee «25__» aa?aniy_ 1999 ?.
A/aiee nae?aoa? niaoeiaeiciaaii? a/aii?
?aaee, eaiaeeaeao iaaee/ieo iaoe, aeioeaio E.N. Oaoeueea
CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE
Aeooaeuei?noue oaie aeine?aeaeaiue. Neo?e?n – iaeia c iaea?eueoa
iioe?aieo ?ioaeoe?eieo oai?ia a aaaaoueio e?a?iao. Ca aeaieie AIIC o
na?o? ui??/ii ca?aaea?oueny 12-15 i?eueeii?a /ieia?e [Aeiaayi A.A. ?
ni?aaao., 1995, 1998; I?ann-?aeec AIC, 1995; Garnett G.P, 1997].
Caoai?thaai?noue a Oe?a?i? oaae aeineoue aeniea, oi/a iai?oeeany
oaiaeaioe?y aei ?? cieaeaiiy. Ca aeaieie Oeaio?o iaaee/ii? noaoenoeee
IIC Oe?a?ie, ia 100 000 ianaeaiiy ciiao aeyaeaieo aeiaaee?a neo?e?no
aoei: a 1995 ?ioe? – 118,9; a 1996 – 150,9; a 1997 – 147,1; 1998 –
137,3. Ia no/aniiio aoai? neo?e?n ia?aa?aa? c iacia/ieie i?iyaaie ia
oe??? ? neeciaeo iaieiieao, i?ioa, /anoioa oneeaaeiaiue c aieo ia?aiai?
nenoaie ? aioo??oi?o i?aai?a cia/ii ca?eueoeeany [Iaa?ia E.E., 1996;
Iaeauoe 0.0., 1998]. Aoaeoeaia e?eoaaiiy oai?eo ? ?oi?o noaoaaeo
eiioaeo?a aeicaiey? ia?a?aaoe iioe?aiiy ?ioaeoe?? ? iiia?aaeeoe i?ci?
oneeaaeiaiiy.
Iai?oeee?ie caeeoathoueny iniiaieie caniaaie aeey e?eoaaiiy neo?e?no
[Aaeoeaaa Y.A. ? ni?aaao., 1992; Einaaa I.E. ? ni?aaao., 1998;
Ia/eiieeia E.I. ? ni?aaao.1980; Naiaiooa E.A., 1994; Iaa?ia, E.E. ?
ni?aaao., 1999; Musher P.N., Rolfs R.T., 1990]. Canoinoaaiiy iao???ai? ?
eae??ai? nieae aaiceeiai?oeee?io aoaeoeaii, i?ioa iio?aao? aaaaeaiiy
i?aia?aoo eiaei? 3-4 aiaeeie, ui iiaeeeai o?eueee a oiiaao noaoe?iia?o.
Aeth?aioi? i?aia?aoe iai?oeee?io – aaicaoei-iai?oeee?ie a?aeiinii
aoaeoeai?. I?ioa, inoaii?ie ?ieaie noaee iaeiie/oaaoeny aeai? i?i
aeiaaeee ee?i?/ieo ? na?ieia?/ieo ?aoeeaeea?a, na?i?acenoaioiino?, a
oaeiae ?icaeiaiiy i?ci?o oi?i o iaoe??io?a, ui e?eoaaeenue
i?ieiiaiaaieie iai?oeee?iaie [Aooiaa A.E., Ooiaea A.A., 1998; Iaa?ia,
E.E. ? ni?aaao., 1999; I?eei A.O. ? ni?aaao., 1999; Mann J. Et al, 1994;
Erbelding E., 1997]. I/aaeaeii, aeoi??y, aeeeeeaia ia?oei oni?oiei
aeina?aeii canoinoaaiiy aeth?aioieo iai?oeee?i?a, eiee neo?e?n
aee?eiaoaaee “iaeiith ?i’?eoe??th” aaea iicaaeo. Iac??ea iaiao?aei?noue
a iiaeo iaoiaeao niaoeeo?/ii? oa?ai?? c o?aooaaiiyi iniaeeainoae
ai?aeai?ieia?? ? ee?i?ee neo?e?no, ia iniia? aea/aiiy iaoiaaiaco
caoai?thaaiiy ? oa?iaeieia?/ieo aeanoeainoae, iiaeo i?aia?ao?a
iai?oeee?iiaiai ?yaeo. E?eoaaiiy neo?e?no iiaeiii aooe ia o?eueee
aoaeoeaiei, aea oaeiae iaeiooiaiei, c?o/iei, aeinooiiei.
Ca’ycie ?iaioe c caieaiiaaiith iaoeiaith oaiaoeeith. Aeine?aeaeaiiy ?
o?aaiaioaie ieaiiaeo iaoeiai-aeine?aeieo oai Oe?a?inueeiai IAe?
aea?iaoieia?? ? aaia?ieia?? IIC Oe?a?ie – “Aea/aiiy no/anieo
iniaeeainoae ai?aeai?ieia?? ? ee?i?/iiai ia?aa?ao neo?e?oe/ii?
?ioaeoe??, ?ic?iaea iiaeo cania?a ae?aaiinoeee ? iaoiae?a e?eoaaiiy
ca?acieo oi?i neo?e?no” (? aea?ae?aa?no?aoe?? 0195V026587) oa “Ci?oai?
aaia?e/i? ?ioaeoe??: ai?aeai?ieia?y, ae?aaiinoeea, ee?i?ea, iaoiaaiac,
e?eoaaiiy, i?io?eaeoeea” (? aea?ae?aa?no?aoe?? 0197V015565).
Iaoa ? caaea/? aeine?aeaeaiiy. ?ic?iaeoe iia? iaoiaee e?eoaaiiy oai?eo
ia ?aii? oi?ie neo?e?no i?iea?i-iai?oeee?iii o ii?aeiaii? c
aaicaoei-iai?oeee?iii, a oaeiae oaiien?iaoeeiai?oeee?iii c o?aooaaiiyi
iniaeeainoae ee?i?ee, iaoiaaiaco caoai?thaaiiy ? oa?iaeioa?aiaaoe/ieo
aeanoeainoae oeeo i?aia?ao?a.
Caaea/?:
Aecia/eoe ee?i?/i? iniaeeaino? ? oa?aeoa? ia?aa?ao ?aiiueiai neo?e?no ia
no/aniiio aoai?. Ii??aiyoe i?iyae neo?e?no o oai?eo, ui iaoeathoue o
??cieo aaia?ao?/ieo ciiao.
C’ynoaaoe oa?iaeie?iao/i? iniaeeaino? i?iea?i-iai?oeee?io ?
aaicaoei-iai?oeee?io i?e e?eoaaii? oai?eo ia neo?e?n.
C’ynoaaoe oa?iaeie?iaoe/i? iniaeeaino? oaiien?iaoeeiai?oeee?io, i?e
e?eoaaii? oai?eo ia neo?e?n.
I?iaanoe ii??aiyeueiee aiae?c iaeaeeae/eo ? a?aeaeaeaieo ?acoeueoao?a
e?eoaaiiy oai?eo ia neo?e?n ?c canoinoaaiiyi i?iea?i-iaieoeeeeeio ?
aaicaoei-iaieoeeeeeio.
I?iaanoe ii??aiyeueiee aiae?c iaeaeeae/eo ? a?aeaeaeaieo ?acoeueoao?a
e?eoaaiiy oai?eo ia neo?e?n ?c canoinoaaiiyi oaiien?iaoeeiaieoeeeeeio.
Cai?iiiioaaoe iia? iaoiaeeee e?eoaaiiy oai?eo ia ?aii? oi?ie neo?e?no ?
?ic?iaeoe e?eoa??? ioe?iee ?oiuei? aoaeoeaiino?.
Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Anoaiiaeaii ee?i?/i?
iniaeeaino? neo?e?no ia no/aniiio aoai?. I?iaaaeaii ii??aiyiiy i?iya?a
neo?e?no o oai?eo, ui aeeaooue o ??cieo aaia?ao?/ieo ? nioe?aeueieo
oiiaao – a i. Aaeo ? a i. Oa?eia?. Oea aeicaieeei aecia/eoe, ye?
ee?i?/i? iciaee a?eueoa, a ye? iaioa noeeuei? aei aieeao c aieo
ciai?oieo /eiiee?a. Aea/aii oa?iae?iaoe/i? iniaeeaino?
i?iea?i-iai?oeee?io ? aaicaoei-iai?oeee?iio, a oaeiae
oaiien?iaoeeiai?oeee?io i?e e?eoaaiiy oai?eo ia neo?e?n. ?ic?iaeaii iia?
iaoiaee e?eoaaiiy oai?eo ia ?aii? oi?ie neo?e?no. I?iaaaeaii
ii??aiyeueiee aiae?c iaeaeeae/eo ? a?aeaeaeaieo ?acoeueoao?a e?eoaaiiy
neo?e?no c canoinoaaiiyi oaiien?iaoeeiai?oeee?io, i?iea?i-iai?oeee?io ?
aaicaoei-iai?oeee?io. Cai?iiiiiaaii iia? e?eoa??? ioe?iee aoaeoeaiino?
e?eoaaiiy oai?eo ia ?aii? oi?ie neo?e?no.
I?aeoe/ia cia/ei?noue iaea?aeaieo ?acoeueoao?a. Cai?iiiiiaaii aoaeoeai?
? c?o/i? iaoiaeeee e?eoaaiiy ?aiiueiai neo?e?no, ?ic?iaeaii iia?
e?eoa??? ioe?iee aoaeoeaiino? e?eoaaiiy. ?ic?iaeai? iaoiaee e?eoaaiiy
oai?eo ia neo?e?n ai?iaaaeaeai? a ?iaioo ianooiieo
e?eoaaeueii-i?io?eaeoe/ieo ? iaoeiai-iaaeaaia?/ieo onoaiia: ee?i?e
Oe?a?inueeiai IAe? aea?iaoieia?? ? aaia?ieia??, E?einueeiai
?anioae?eainueeiai oe??ii-aaia?ieia?/iiai aeeniaina?o (OAAe),
Aei?i?iiao?ianueeiai, Aeiiaoeueeiai, Noinueeiai ? Ieeiea?anueeiai
iaeanieo OAAe, eaoaae? oe??ieo ? aaia?e/ieo oai?ia Aeiiaoeueeiai,
Caii??cueeiai, iaaee/ieo oi?aa?neoao?a, iaaee/iiai oaeoeueoaoo
Noinueeiai aea?aeaaiiai oi?aa?neoaoo.
Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai naiino?eii i?iaaaeaii aiae?c
iaoeiaeo ioae?eaoe?e, ?ic?iaeaii ieai aeena?oaoe??, i?iaaaeaia ee?i?/ia
ianoaaeaiiy 161 oai?iai ia ?aii? oi?ie neo?e?no. A on?o eaai?aoi?ieo
aeine?aeaeaiiyo aaoi? i?eeiaa iniaenoo o/anoue. Noaoenoe/ia
ii?aoethaaiiy e ?ioai?aoaoe?y io?eiaieo aeaieo a oaeiae aeniiaee
c?iaeai? aaoi?ii.
Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? iaaiai?aii
ia can?aeaii? oiai?eonoaa aea?iaoiaaia?ieia?a ?anioae?ee Aca?aaeaeaeai
18.03.1997, ia iaoe?iiaeuei?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Caoai?thaaiiy, ui ia?aaeathoueny noaoaaei oeyoii, a Oe?a?i?” (Ee?a,
aa?anaiue 1998 ?.), ia iaoeiai-i?aeoe/ieo eiioa?aioe?yo
aea?iaoiaaia?ieia?a o i?noao Aei?i?iiao?ianueeo (eenoiiaae 1998 ?.) ?
Eoaainueeo (ea?oaiue 1999), a oaeiae ia VII C’?cae? aea?iaoiaaia?ieia?a
Oe?a?ie (7-10 aa?aniy 1999 ?., i. Ee?a).
Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? ioi?ieaii cayaeo ia iaoaio,
aeaeaii iaoiaee/i? ?aeiiaiaeaoe??, iioae?eiaaii 14 ?ia?o, c yeeo 6
aeo?iaeueieo noaoae.
No?oeoo?a aeena?oaoe??. Aeena?oaoe?y neeaaea?oueny c anooio, iaeyaeo
e?oa?aoo?e (?icae?e 1), iieno iaoa??ae?a ? iaoiae?a (?icae?e 2)
?acoeueoao?a aeanieo aeine?aeaeaiue (?icae?e 3), iaaiai?aiiy iaoeiai? ?
i?aeoe/ii? cia/eiino? ?acoeueoao?a (?icae?e 4), aeniiae?a ? nieneo
e?oa?aoo?e. Iaaiaeyoueny iiai? a?ae?ia?ao?/i? aeai? i?i 177 aeaea?ae –
96 ia oe?a?inuee?e ? ?in?enuee?e iiaao, a 81 – ia aiae?enuee?e oa ?ioeo
?a?iiaenueeeo iiaao. ?oeiien aeena?oaoe?? aeeeaaeaii ia 110 noi??ieao
oaenoo, caa?noaiiai ia eiii’thoa?? (?aaeaeoi? Microsoft Word’97; o?eoo
Times New Roman, ?ici?? 14 ioieo?a, ?ioa?aae 2) ? i?noeoue 12 oaaeeoeue
? 11 iaethie?a.
IAOIAeE AeINE?AeAEAIIss
C a?oaeiy 1995 ?. ii n?/aiue 1999 ?. aoa ianoaaeaiee 161 oai?ee ia
?aii?e neo?e?n (no?ie ca?aaeaiiy aei 1 ?ieo), ui neeaee aea?
aeine?aeaeoaai? a?oie (? e ??). A?oia I (84 oai?eo) e?eoaaeany a
aea?iaoiaaia?ieia?/iiio a?aeae?eaii? iie?ee?i?ee ? 19 ? I?nueeiio OAAe
i. Aaeo. A?oia II (77 oai?eo) e?eoaaeany a Oe?a?inueeiio IAe?
aea?iaoieia?? oa aaia?ieia??, i. Oa?e?a.
Na?aae 84 oai?eo a?oie I /ieia?e?a aoei 59 (70%), ae?iie – 25 (30%).
Na?aaei?e a?e oai?eo o a?oi? I aoa 22,7 ?ie?a. Ia?aeiiee neo?e?n a a?oi?
I aoei ae?aaiinoiaaii o 17 oai?eo (20%), aoi?eiiee neo?e?n – o 35 (42%),
neo?e?n eaoaioee ?aii?e – o 32 (38%). A?oia I neeaaeaeany c aeaio
ii??aithaaieo i?aea?oi: iniiaii? i?aea?oie IA, ui iaea?aeoaaea
i?iea?i-iai?oeee?i G a niieo/aii? c aaicaoei-iai?oeee?iii G (41 oai?ee)
? i?aea?oie ii??aiyiiy IA, ui iaea?aeoaaea e?eoaaiiy o?eueee
aaicaoei-iai?oeee?iii G (43 oai?eo).
Na?aae oai?eo a?oie II /ieia?e?a aoei 43(56%), ae?iie – 34(44%).
Na?aaei?e a?e oai?eo o a?oi? II aoa 23,1 ?ie?a. Ia?aeiiee neo?e?n o
a?oi? II ae?aaiinoiaaii o 12(16%), aoi?eiiee neo?e?n – o 35(45%).
Neo?e?n eaoaioee ?aii?e – o 30 (39%). A?oia II oaeiae neeaaeaeany c
aeaio ii??aithaaieo i?aea?oi: iniiaii? i?aea?oie IIA, ui iaea?aeoaaea
oaiien?iaoeeiai?oeee?i (48 oai?eo) ? i?aea?oie ii??aiyiiy IIA, ui
iaea?aeoaaea e?eoaaiiy iao???aith n?eeth aaiceeiai?oeee?io (29 oai?eo).
Na?ieia?/i? iaoiaee aeine?aeaeaiiy aeeth/aee noaiaea?oiee eiiieaen
na?ieia?/ieo ?aaeoe?e (EN?) – ?aaeoe?th ca’ycoaaiiy eiiieaiaioo c
ea?ae?ie?i?iiaei ? o?aiiiaiiei aioeaaiaie ? i?e?i?aaeoe?th
i?aoeei?oaoe?? ?c ea?aeeie?i?iiaei aioeaaiii, a oaeiae ?aaeoe?th
eioiioeoi?anoeaioe?? – ??O-200 ? c iiaeeo?eaoe??th ??O-aan ? ?aaeoe?th
?iiia?e?caoe?? ae?aeeo o?aiiiai (??O). Na?ieia?/i? ?aaeoe?? i?iaiaeeee
a?aeiia?aeii /eiiiai Iaeaco IIC ? 204 a?ae 29.12.92. I?ney e?eoaaiiy
aeine?aeaeaiiy i?iaiaeeee uii?ny/ii i?ioyaii no?ieo, iaaiai?aiiai a
?ino?oeoe?? IIC Oe?a?ie 1995 ?ieo.
Aecia/aiiy eiioeaio?aoe?? iai?oeee?io a ne?iaaooe? e?ia? i?iaiaeeee
iaoiaeii aenieiaoaeoeaii? ??aeeiii? o?iiaoia?ao??. I?aeaiooaaiiy c?ace?a
aeey aeine?aeaeaiiy, ?oiy aeno?aeoe?y e i/euaiiy i?iaiaeeeeny ia iniia?
iaoiaeee, iienaieo Boatto G. ? ni?aaao., 1997 (aeey aaiceeiai?oeee?io) ?
Lindberg R.L. ? ni?aaao. , 1984 (aeey oaiien?iaoeeiai?oeee?io). C?acee
caa??aaeeny i?e –200 N ia a?eueo 3-o i?nyoe?a aei i?iaaaeaiiy aiae?co.
I?ney ?acii?iaeoaaiiy 2 ie ne?iaaoee i?iioneaeiny /a?ac iao?ii AeEAIAE
N16. Iao?ii i?iieaaany 2 ie aeenoeeueiaaii? aiaee. Iio?i iai?oeee?i
cieaaany c iao?iia 2 ie aoeaoii?o??ea (MERCK). O?eueo?ao aenoooaaany,
inaae ?ic/eiyany a 0,2 ie aeenoeeueiaaii? aiaee. A yeino? noaiaea?oo
aeei?enoiaoaaeeny aiaeyi? ?ic/eie i?aia?ao?a: ?aoa?iai (Benzathine
Benzylpenicillin, Biochemie); i?iea?i iai?oeee?i G (Penicillin G
procain, Biochemie); aaiceeiai?oeee?io iao???aa n?eue
(Benzylpnnicillinum-natrium, Ee?aiaaei?aia?ao); Phenoxymethylpenicillin
(Megacillin, Cheiie Grunental GMBH-Stolberg/RHLD, aeica?e Oa?ieii?oaoo
Oe?a?ie ? 171 a?ae 08.12.94 ?.). Aiae?c i?iaiaeeany c aeei?enoaiiyi
??aeeiiiai o?iiaoia?aoa Beckman c eieiieith Cenapon SCX C18 4o100 ii.
Oeueo?ao?ieaoiaee aeaoaeoi?, aoei anoaiiaeaii ia oaee? aeiaaeeiith 230
ii. ?ooeeaa oaca neeaaeaeany c 20 % aoeaoii?o??eo (MERCK) ? 80 %
aeenoeeueiaaii? aiaee, ?H 3,0. ?ooeeaa oaca iiaeaaaeany c? oaeaee?noth
0,5 ie/oa. Ia’?i c?acea, ui aaiaeeany neeaaeaa 50 iee. Aecia/aee oae?
oa?iae?iaoe/i? iieacieee: Cmax – iaeneiaeueia eiioeaio?aoe?y a
ne?iaaooe? e?ia?; Cm- na?aaeiy eiioeaio?aoe?y a ne?iaaooe? e?ia? ca
ia??iae niinoa?aaeaiiy; Omax – /an aeinyaiaiiy iaeneiaeueii?
eiioeaio?aoe??; AUC (area under curve) – ieiua o?ao?e i?ae e?eaith, ui
a?aeaeaa? caeaaei?noue eiioeaio?aoe?? a?ae /ano; T1/2 – ia??iae
iai?aaeaaaeaiiy – /an, iaiao?aeiee aeey ciaioaiiy aaea?/? eiioeaio?aoe??
a e?ia?; Vd – ia’?i ?iciiae?eo – a?iioaoe/iee ia’?i ??aeei i?aai?cio,
iaiao?aeiee aeey ??aiii??iiai ?iciiae?eo an??? e?eueeino? aaaaeaii?
?a/iaeie a eiioeaio?aoe??, ui aei??aith? eiioeaio?aoe?? a e?ia?.
Iaoaiaoe/ia ii?aoethaaiiy io?eiaieo aeaieo i?iaiaeeeiny eiii’thoa?? c
aeei?enoaiiyi i?ia?ai SYSTEM GOLD HPLC-P/ACE Tutorial ? Microsoft
Excel’97. Aeey eiaeii? aea??ee i?iaiaeeeiny ia/eneaiiy: na?aaeiueiai
a??oiaoe/iiai, noaiaea?oii? iiieeee, iiaee, iaae?aie, noaiaea?oiiai
a?aeoeeaiiy, aeenia?n??, aneiao??? e aenoeano. Ii??aiyiiy na?aaei?o
?iaeee ca aeiiiiiaith aeaooaea??eiaeo Z-oanoo ? t-oanoo. Aeey ii??aiyiiy
aea??ie aoa canoiniaaiee aeaioaeoi?iee aeenia?n?eiee aiae?c (F-oano) ?
?aa?aneaiee aiae?c. Aoa i?eeiyoee ??aaiue iaae?eiino? 95%.
?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss
Ee?i?ea neo?e?no – aeyaeai? iniaeeaino?. A?oie oai?eo I e II aoee
?icae?eai? oa?eoi??aeueii e ciaoiaeeeenue a ??cieo oiiaao. Aea/aiiy
?oi?o ee?i?/ieo iniaeeainoae i?iaiaeeeinue ie?aii (iaeii/aniaa,
aaaaoioeaio?iaa, i?iniaeoeaia aeine?aeaeaiiy). *anoioe ee?i?/ieo i?iya?a
neo?e?no a a?oiao I e II iaaaaeai? a oaaeeoe? 1.
Oaaeeoey 1.
Iniaeeaino? ee?i?/ieo i?iya?a ?aiiueiai neo?e?no
Ee?i?/ia iciaea A?oia I A?oia II ?=
Noiooiy iaoieia?y (%) 34 (41%) 18 (23%) 0,0145 SYMBOL 42 \f “Symbol” \s
13.5 *
?ieoaaoe?eiee ia??iae (oeaei?) 4,4 SYMBOL 177 \f “Symbol” \s 13.5 ± 0,4
4,1 SYMBOL 177 \f “Symbol” \s 13.5 ± 0,1 0,1898
A?iceaiee oaiea? (%) 16 (53%) 12 (60%) 0,6275
Ae?aceiaee oaiea? (%) 14 (47%) 8 (40%) 0,625
Oneeaaeiai? oaiea?e (%) 10 (33%) 4 (20%) 0,3087
Aoeiia? oaiea?e (%) 4 (33%) 2 (10%) 0,7461
Ae?aiao? e?ioiaoce?a (ni) 1,6 SYMBOL 177 \f “Symbol” \s 13.5 ± 0,2 1,5
SYMBOL 177 \f “Symbol” \s 13.5 ± 0,2 0,4962
?icaiea (%) 24 (69%) 21 (60%) 0,4319
Niaoeeo?/ia aia?ia (%) 29 (83%) 26 (74%) 0,3585
Iaioee ia ooeoa (%) 15 (43%) 22 (63%) 0,0956
Iaioee aeieiiii-i?aeioiai?(%) 21 (60%) 22 (63%) 0,7961
Iaioee ia aaieoae?yo (%) 28 (80%) 19 (54%) 0,0214 SYMBOL 42 \f
“Symbol” \s 13.5 *
Oe?ie? eiiae?eiie (%) 19 (54%) 9 (26%) 0,0177 SYMBOL 42 \f “Symbol” \s
13.5 *
Iaioee a ii?iaeiei? ?ioa (%) 29 (83%) 14 (40%) 0,0003 SYMBOL 42 \f
“Symbol” \s 13.5 *
Iaioee ia aieineno?e /anoei? aieiae (%) 10 (29% 4 (11%) 0,0579
Aeiiaoe?y (%) 3 (9%) 7 (20%) 0,1879
Noiooiy iaoieia?y o oai?eo a?oie ? niinoa??aaeany a 1,8 ?ace /ano?oa
i?ae a a?oi? ?? (?=0,0145). A?ae??ciyany e oa?aeoa? noiooiuei?
iaoieia??. O a?oi? ? ia?aaaaeaee caoai?thaaiiy oeoieiai-eeoeiaiai
o?aeoo, ia/?iee ? ia?aiai? nenoaie, a a a?oi? ?? – a?iaeieia?/ia e
o?ieia?/ia iaoieia?y. *anoioa ee?i?/ieo iciae, ui oa?aeoa?ecothoue
ia?aa?a ?aiiueiai neo?e?no a aeine?aeaeoaaieo a?oiao, a??ia?aeii ia
a?ae??ciyeanue. Aeiyoie neeaaeathoue: /anoioa iaioe a iaeano? aai?oae?e,
oe?ieeo eiiaeeeii ? iaioe ia neeciai? ?ioa (a?aeiia?aeii a 1,5; 2,8 ?
2,1 ?ace) (Oaaeeoey 1). Oe? ?icoiaeaeaiiy iiaeooue aooe iia’ycai? c oei,
ui a a?oi? ? ia?aaaaeaee oai??, ui aoee aeyaeai? aeoeaii (a?aeiia?aeii
38% ? 21%, ?=0,0183). C ee?i?/ii? i?aeoeee a?aeiii, ui yeui ee?i?/i?
i?iyae aoi?eiiiai neo?e?no iaiaaeothoueny aeneiii ia neeciaeo iaieiieao
?ioa ? aai?oae?e, oi aiie iiaeooue aooe iaiii?oi? aeey oai?iai. O
oeueiio aeiaaeeo a?eueo a??ia?aeia aeoeaia aeyaeaiiy, a ia naiino?eia
caa?oaiiy ca iaaee/iith aeiiiiiaith. Na?aaeiy o?eaae?noue ?ieoaaoe?eiiai
ia??iaeo ia?aaeuoaaea 4 oeaei?, ui aeae?eueea a?ae??ciy?oueny a?ae 3-o
oeaei?a, iienaieo o eeane/ieo iin?aieeao. Na?aae iniaeeainoae ee?i?ee
ia?aeiiiai neo?e?no a?aecia/ai? iacia/i? ?ici??e e?ioaoe/ieo aoce?a i?e
?aa?iia?iiio neea?aaeai?o? ? cia/ia /anoioa niaoeeo?/ii? aia?ie a iaio
a?oiao oai?eo. O a?oi? ? a?aecia/aiee aeineoue aenieee a?aenioie oai?eo
?c naai?aeieie iaioeaie ia aieineno?e /anoei? aieiae. Oea ia?aaeuoaaei
aiaeia?/iee iieaciee o a?oi? II a 2,6 ?ace, i?ioa ?icoiaeaeaiiy ia
aeinyaee aeia??/iai ??aiy (?=0,0579). Neo?e?oe/ia ie?oea?noue
(aeiiaoe?y) i?eaeecii a aeaa ?ace /ano?oa niinoa??aaeany o oai?eo a?oie
II (20%) o ii??aiyii? c a?oiith I, aea oea ?icoiaeaeaiiy noaoenoe/ii
iaa??ia?aeii (?=0,1879).
Iaa?oiooaaiiy noai e?eoaaiiy oai?eo ia ?aii? oi?ie neo?e?no c
o?aooaaiiyi oa?iaeie?iaoeee i?iea?i-iai?oeee?io ? aaicaoei-iai?oeee?io,
a oaeiae oaiien?iaoeeiai?oeee?io
Oa?iae?iaoe/i? aeine?aeaeaiiy i?iaiaeeeeny o 18 oai?eo ia neo?e?n, ui
aoee a?ae?a?ai? aeia?eueii c a?oi I ? II. ?acoeueoaoe oa?iae?iaoe/ieo
aeine?aeaeaiue iiaeai? a oaaeeoeyo 2-5 ? ia iaethieao 1-3. C a?oie I
aoei a?ae?a?aii 9 oai?eo. I’youe iaoe??io?a c iniiaii? i?aea?oie IA,
/ioe?e iaoe??ioe – ?c i?aea?oie ii??aiyiiy IA. I?aea?oia IA –
neeaaeaeany c oai?eo, eio?ei o yeino? niaoeeo?/iiai e?eoaaiiy aoa
i?ecia/aiee i?iea?i-iai?oeee?i 2,4 iei. IAe a iaeio n?aeieoeth,
aaicaoei-iai?oeee?i 2,4 iei. IAe a ?ioo n?aeieoeth iaeii?aciai i?e
ia?aeiiiio neo?e?n?; i?e aoi?eiiiio neo?e?n? – ae?oaa ?i’?eoe?y 2,4 iei.
IAe aaicaoei-iai?oeee?io /a?ac 7 aei?a ? i?e neo?e?n? ?aiiueiio
eaoaioiio – /a?ac 7 aei?a aaicaoei-iai?oeee?i 4,8 iei. IAe (ii 2,4 iei.
IAe a iaeaea? n?aeieoe?). I?aea?oia IA – iaea?aeoaaea e?eoaaiiy ca
iaoiaeeeith, ?aeiiaiaeiaaii? AIIC. I?e ia?aeiiiio neo?e?n? i?ecia/aee
2,4 ie IAe aaicaoei-iai?oeee?io iaeii?aciai; i?e aoi?eiiiio ? ?aiiueiio
eaoaioiio neo?e?n? – 2,4 ie IAe aaicaoei-iai?oeee?io aeai?aciai c
?ioa?aaeii a 1 oeaeaeaiue. A a?oi? I acyooy e?ia? i?iaiaeeeinue /a?ac 1,
6, 12, 24 aiaeeie i?ney ii/aoeo e?eoaaiiy ? aeae? uiaeiae i?ioyaii 7
ae?a – /a?ac 48, 72, 96, 120, 144 ? 168 aiaeei. C a?oie II, ui oaeiae
neeaaeaeany c aeaio ii??aithaaieo i?aea?oi – iniiaii? i?aea?oie IIA ?
i?aea?oie ii??aiyiiy IIA, aoei a?ae?a?aii 9 iaoe??io?a. I’youe oai?eo ?c
i?aea?oie IIA, yeei aoa i?ecia/aiee oaiien?iaoeeiai?oeee?i ii 2 iei. IAe
aioo??oiueii’yciai 1 ?ac ia aeaiue, ? 4 oai?eo ?c i?aea?oie IIA, ui
e?eoaaeeny iao???aith n?eeth aaiceeiai?oeee?io ii 1 iei. IAe
aioo??oiueii’yciai eiaei? 3 aiaeeie. O a?oi? II acyooy e?ia?
i?iaiaeeeinue i?ioyaii ia?oi? aeiae i?ney ii/aoeo e?eoaaiiy – /a?ac 0,5,
1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 18 ? 24 aiaeeie. Ia i?aenoaa?
io?eiaieo cia/aiue eiioeaio?aoe?? aaiceeiai?oeee?io ?
oaiien?iaoeeiai?oeee?io a e?ia? aoaeoaaee oa?iae?iaoe/io e?eao, ui
ae?aaeaea ona?aaeiaio caeaaei?noue eiioeaio?aoe?? a?ae /ano.
I?ioyaii ia?oi? aeiae na?aaeiy eiioeaio?aoe?y aaiceeiai?oeee?io i?e
ii?aeiaiiio e?eoaaii? i?iea?iii ? aaicaoeiii aoea 4,2 iea/ie, a i?e
e?eoaaii? o?eueee aaicaoeiii – 0,2 iea/ie, oiaoi aoea a?eueoa a 22 ?ace
(oaaeeoey 2).
Oaaeeoey 2.
Na?aaeiy eiioeaio?aoe?y iai?oeee?io a ne?iaaooe? e?ia?(iea/ie) i?ioyaii
7 ae?a a a?oi? I.
Aiaeeie
A?oie 1 6 12 24 48 72 96 120 144 168
IA 8,46 5,68 2,21 0,25 0,17 0,16 0,11 0,08 0,07 0,06
IA 0,06 0,28 0,25 0,17 0,12 0,1 0,08 0,07 0,07 0,06
I?ioyaii ianooiieo 2-7 ae?a eiioeaio?aoe?y aaiceeiai?oeee?io a
i?aea?oiao a??ia?aeii ia a?ae??ciyeany. Ii?aeiaia canoinoaaiiy
i?iea?i-iaioeoeee?io aeiaeaoeiai aei aaicaoei-iai?oeee?io aeicaieeei
?noioii iie?ioeoe oa?iae?iaoe/i? iieacieee, ui oa?aeoa?ecothoue
iane/aiiy i?aai?cio aaiceeiai?oeee?iii (oaaeeoey 3).
Oaaeeoey 3
Oa?iae?iaoe/i? ia?aiao?e i?e aecia/aii? eiioeaio?aoe?? aaiceeiai?oeee?io
a e?ia? o oai?eo a?oie I
Oa?iae?iaoe/iee iieaciee I?aea?oia IA I?aea?oia IA
Cm – Na?aaeiy eiioeaio?aoe?y (iea/ie) 2,73 0,18
Cmax – iaeneiaeueia eiioeaio?aoe?y (iea/ie) 9,72 0,34
Omax-/an aeinyaiaiiy iaeneiaeueii? eiioeaio???(aiaeeie) 2 8
AUC – ieiua i?ae e?eaith [(iea/ie) o aiae] 96,8 18,22
T1/2 – ia??iae iai?aaeaaaeaiiy (aiaeeie) 4,8(120) 145
Vd – ia’?i ?iciiae?eo (e) 1052,3 8084,5
Na?aaeiy eiioeaio?aoe?y iai?oeee?io a e?ia? ca aanue /an niinoa?aaeaiiy
aoea a?eueoa a 15,2 ?ace, iaeneiaeueiee ??aaiue eiioeaio?aoe?? o oai?eo
iniiaii? i?aea?oie ia?aaeuoaaa oeae iieaciee a i?aea?oi? ii??aiyiiy a
28,6 ?ace ? aeinyaaany a 4 ?ace oaeaeoa. O i?aeoe/iiio ieai? oea
icia/a?, ui a?ae?aco i?ney ii/aoeo e?eoaaiiy
noai?th?oueny aeniea eiioeaio?aoe?y iai?oeee?io a i?aai?ci?, ui aaaeeeai
aeey caiia?aaiiy aeaeeaaiiy ae?aeeo o?aiiiai. Ieiua i?ae e?eaith
«eiioeaio?aoe?y-/an», o oai?eo, ui iaea?aeoaaee i?iea?i-iai?oeee?i o
niieo/aii? c aaicaoei-iai?oeee?iii, aoea a 5,3 ?ace a?eueoa, i?ae o
oai?eo, ui iaea?aeoaaee o?eueee aaiceoei-iai?oeee?i. Oeae iieaciee
oa?aeoa?eco? nooi?iue oeo/aiiy i?aia?aoo a e?ia ? o?eaae?noue eiai
ia?aaoaaiiy oai. A ia?oo aeiao ia??iae iai?aaeaaaeaiiy a iniiai?e
i?aea?oi? IA aoa o 30 ?ac?a iaioa, i?ae a i?aea?oi? ii??aiyiiy IA.
Iio?i, c /aoaa?oi? aei nueiii? aeiae, a?i o ii??aithaaieo i?aea?oiao
?noioii ia a?ae??ciyany. Oaea ea?oeia a?aeaeaa? aeaaaeaiiy iai?oeee?io,
aaaaeaiiai o oi?i? i?iea?ia, i?ioyaii ia?oeo o?ueio ae?a, a iio?i e?eaa
i?eeia? aeaeyae, oa?aeoa?iee aeey oa?iaeie?iaoeee
aaicaei-aaiceeiai?oeee?io (iae. 1).
Ia’?i ?iciiae?eo oaeiae cia/ii ??cieany a ii??aithaaieo i?aea?oiao – o
7,7 ?ace. Iaioee ia’?i ?iciiae?eo i?e canoinoaaii? 2,4 iei. IAe
i?iea?i-iai?oeee?io a niieo/aii? c 2,4 iei. IAe aaicaoei-iai?oeee?io
icia/a?, ui a oeueiio aeiaaeeo e?euee?noue aaiceeiai?oeee?io a oeaieiao
i?aai?cio a?eueoa. I?iea?iiaee iin?e ni?ey? oaeaeeiio iane/aiith
iai?oeee?iii on?o oeaiei i?aai?cio ? aa?aioo? o?aiiiaiaoeeaeio
eiioeaio?aoe?th i?ioyaii aeiae. Aaicaoeiiaee iin?e i?aeo?eio?
aeinoaoith eiioeaio?aoe?th iai?oeee?io a i?aai?ci? i?ioyaii oeaeiy. Oeei
iaa?oioiao?oueny aaaaeaiiy aeiaeaoeiai ?aciai? aeice i?iea?i-iai?oeee?io
2,4 iei. IAe iaeii/anii c ia?oith ?i’?eoe??th 2,4 iei. IAe
aaicaoeiiai?oeee?io.
Iae. 1. Na?aaeiy eiioeaio?aoe?y iai?oeee?io a ne?iaaooe? e?ia? i?ioyaii
2-7 aeiae. Nooe?eueia e?i?y – oai?? a?oie IA, ui iaea?aeoaaee i?iea?i +
aaicaoei. Ia?a?ea/anoa e?i?y – oai?? a?oie IA, ui iaea?aeoaaee o?eueee
aaicaoeiiai?oeee?i.
I?e e?eoaaii? oai?eo ia neo?e?n oaiien?iaoeeiai?oeee?iii eiai
eiioeaio?aoe?y a e?ia? /a?ac 1 aiaeeio i?ney aaaaeaiiy a o?e ?ace
ia?aaeuoaaea eiioeaio?aoe?th aaiceeiai?oeee?io, /a?ac 2 aiaeeie – o
i’youe ?ac?a, /a?ac 3 aiaeeie – o a?n?i ?ac?a. I?ney ae?oai? ?i’?eoe?? 1
iei. IAe aaiceeiai?oeee?io (/a?ac 4 aiaeeie i?ney ii/aoeo
niinoa?aaeaiiy) a?aeaoeiny ae??aithaaiiy eiioeaio?aoe?e i?ae iniiaiith
i?aea?oiith IIA ? i?aea?oiith ii??aiyiiy IIA, i?ioa, o ca’yceo c a?eueo
oaeaeeei aeaaaeaiiyi aaiceeiai?oeee?io a ii??aiyii? c
oaiien?iaoeeiai?oeee?iii, /a?ac 5 aiaeei eiioeaio?aoe?y
oaiien?iaoeeiai?oeee?io ana ua ia?aaeuoaaea eiioeaio?aoe?th
aaiceeiai?oeee?io a 1,6 ?ace, a /a?ac 6 aiaeei – o aeaa ?ace. C 7-i? aei
24-i? aiaeeie eiioeaio?aoe?y iai?oeee?io a iniiai?e i?aea?oi? aoea 1,7
iea/ie, ui a 93 ?ace a?eueoa i?i?iaeueii? o?aiiiaiaoeeaeii?
eiioeaio?aoe??. *a?ac 24 aiaeeie – oiaoi ia?aae /a?aiaith ?i’?eoe??th
oaiien?iaoeeiai?oeee?io – eiioeaio?aoe?y iai?oeee?io a ne?iaaooe? e?ia?
neeaaeaea 0,06 iea/ie, ui a 3 ?ace ia?aaeuoaaei iaiao?aeiee i?i?ioi
(0,018 iea/ie) (Oaaeeoey 4). Canoinoaaiiy iaeii? ?i’?eoe?? 2 iei. IAe
oaiien?iaoeeiai?oeee?io ia aeiao aeicaiey? caaacia/eoe aeinoaoi?
iane/aiiy i?aai?cio iai?oeee?iii, iaiao?aeia aeey e?eoaaiiy ?aii?o oi?i
neo?e?no i?e caa??aaii? aaeaeaaoii? o?eaaeino? eo?no e?eoaaiiy. I?e
cia/ieo ?icoiaeaeaiiyo i?ae i?i?iaeueiei ? iaeneiaeueiei ??aiyie
i?ioyaii aeiae, na?aaeiy eiioeaio?aoe?y iai?oeee?io a ne?iaaooe? e?ia?
ca /an niinoa?aaeaiiy a iniiai?e i?aea?oi? IIA ? i?aea?oi? ii??aiyiiy
IIA a??ia?aeii ia a?ae??ciyeany – a?aeiia?aeii 7,4 ? 6,8 iea/ie.
Oaaeeoey 4.
Na?aaeiy eiioeaio?aoe?y iai?oeee?io a ne?iaaooe? e?ia? (iea/ie) i?ioyaii
1 aeiae a a?oi? II.
Aiaeeie
A?oie 0,5 1 2 3 4 5 6 7 8 9 10 11 12 18 24
IIA 7,2 28,8 7,4 18,9 11,8 9,9 6,3 5,2 2,9 1,9 1,1 1,2 0,82
0,21 0,06
IIA 8,5 9,5 5,3 2,2 11,8 6,2 3,1 12,1 6,3 3,5 10,7 5,9 3 3,2
2,6
Iaeneiaeueiee ??aaiue eiioeaio?aoe?? o oai?eo iniiaii? i?aea?oie
ia?aaeuoaaa oeae ??aaiue a i?aea?oi? ii??aiyiiy a 1,6 ?ace ? aeinyaaany
ca 1 aiaeeio. O i?aeoe/iiio ieai? oea icia/a?, ui a ia?o? 5-7 aiaeei
i?ney aaaaeaiiy 2 iei. IAe oaiien?iaoeeiai?oeee?io noai?th?oueny aeniea
eiioeaio?aoe?y iai?oeee?io a i?aai?ci?, ii??aiyiia c oith, ui
noai?th?oueny i?e aaaaeaii? 1 iei. IAe aaiceeiai?oeee?io iao???ai? nie?
eiaei? 3 aiaeeie.
Ine?eueee a i?aea?oi? IIA iao???aa n?eue aaiceeiai?oeee?io aaiaeeeanue
aaaaoi?aciai (8 ?ac?a ia aeiao), e?eaa caeaaeiino? eiioeaio?aoe?? a?ae
/ano iaea aeaeyae oaeeynoi? e?i??. O oai?eo iniiaii? i?aea?oie
caeaaei?noue eiioeaio?aoe?? a?ae /ano ia ae?eyieao c?inoaiiy ? iaae?iiy
iineea yeniiiaioe?eiee oa?aeoa? (iae.2).
Iae. 2. Na?aaeiy eiioeaio?aoe?y iai?oeee?io a ne?iaaooe? e?ia? i?ioyaii
2-7 aeiae. Nooe?eueia e?i?y – oai?? a?oie IIA, ui iaea?aeoaaee
oaiien?iaoeeiai?oeee?i. Ia?a?ea/anoa e?i?y – oai?? a?oie IIA, ui
iaea?aeoaaee iao???ao n?eue aaiceeiai?oeee?io
Ieiu? i?ae e?eaeie «eiioeaio?aoe?y-/an», o oai?eo iniiaii? i?aea?oie IIA
? i?aea?oie ii??aiyiiy IIA aoea i?eaeecii iaeiaeia? e a?ae??ciyeeny
ianooo?ai – ia 13% (oaaeeoey 5). Io?eiai? aeai? icia/athoue, ui nooi?iue
oeo/aiiy iai?oeee?io a nenoaiiee e?iaiiio?e i?e canoinoaaii? aeaio
ii??aithaaieo iaoiaeee e?eoaaiiy neo?e?no i?eaeecii iaeiaeiaa. I?ioa, o
aeiaaeeo oaiien?iaoeeiai?oeee?io, oea aeinyaa?oueny ca ?aooiie cia/ii
iaioi? aeiaiai? aeice ? e?eueeino? ?i’?eoe?e. Ia??iae iai?aaeaaaeaiiy a
i?aea?oi? IIA aoa o 2,3 ?ace a?eueoa a ii??aiyii? c i?aea?oiith IIA.
Ia’?i ?iciiae?eo oaeiae cia/ii a?ae??ciyany a ii??aithaaieo i?aea?oiao –
o 3,1 ?ace (oaaeeoey 5). Iaioee ia’?i ?iciiae?eo i?e canoinoaaii? 2 iei.
IAe oaiien?iaoeeiai?oeee?io 1 ?ac ia aeiao a ii??aiyii? c 1 iei. IAe
aaiceeiai?oeee?i iao???aith n?eeth 8 ?ac?a ia aeiao icia/a?, ui a
ia?oiio aeiaaeeo e?euee?noue aaiceeiai?oeee?io a oeaieiao i?aai?cio
a?eueoa.
Oaaeeoey 5
Iniiai? oa?iae?iaoe/i? ia?aiao?e i?e aecia/aii? eiioeaio?aoe??
aaiceeiai?oeee?io a e?ia? o oai?eo a?oie II
Oa?iae?iaoe/iee iieaciee I?aea?oia
IIA I?aea?oia IIA
Cm – na?aaeiy eiioeaio?aoe? (iea/ie) 7,4 6,8
Cmax – iaeneiaeueia eiioeaio?aoe?y (iea/ie) 28,8 18,5
Omax-/an aeinyaiaiiy iaeneiaeueii? eiioeaio?aoe?? (aiae) 1,0 0,5
AUC – ieiua i?ae e?eaith [(iea/ie) o aiae] 116,8 152,2
T1/2 – ia??iae iai?aaeaaaeaiiy (aiae) 1,6 0,7
Vd – ia’?i ?iciiae?eo (e) 226,8 705,72
Oaeei /eiii, oa?iae?iaoe/i? aeine?aeaeaiiy, i?iaaaeai? o oai?eo, ui
iaea?aeoaaee i?iea?i-iai?oeee?i (2,4 iei. IAe) o niieo/aii? c
aaicaoei-iai?oeee?iii (2,4 iei. ), a oaeiae oaiien?iaoeeiai?oeee?i (2
iei. IAe 1 ?ac ia aeiao) aeicaieeee anoaiiaeoe, ui o oai?eo, ye?
iaea?aeothoue e?eoaaiiy i?iea?i-iai?oeee?iii ? aaicaoei-iai?oeee?iii, a
oaeiae oaiien?iaoeeiai?oeee?iii ca cai?iiiiiaaieie iaoiaeeeaie,
noai?th?oueny aeinoaoi? aeey e?eoaaiiy neo?e?oe/ii? ?ioaeoe?? iane/aiiy
i?aai?cio iai?oeee?iii. Cai?iiiiiaai? iaoiaeeee e?eoaaiiy oai?eo ia
?aii? oi?ie neo?e?no aeineoue c?o/i? aeey aiaoeaoi?iiai e?eoaaiiy ?
e?eoaaiiy a oiiaao aeaiiiai noaoe?iia?o. I?e aeei?enoaii?
oaiien?iaoeeiai?oeee?io noia?ia aeica iai?oeee?io a /ioe?e ?ace iaioa,
i?ae i?e aaaaeaii? aiaei?ic/eiii? iao???ai? nie? aaiceeiai?oeee?io
a?aeiiaaeaeii aei /eiii? ?ino?oeoe??.
Iaeaeeae/? ? a?aeaeaeai? ?acoeueoaoe e?eoaaiiy oai?eo
I?e ii??aiyeueiiio aiae?c? aeaio iaoiae?a e?eoaaiiy aeyaeaii, ui i?e
e?eoaaii? i?iea?i-iai?oeee?iii o niieo/aii? c aaicaoeiiai?oeee?iii,
ie?ai? aeoeai? i?iyae neo?e?no cieeaee oaeaeoa, i?ae i?e e?eoaaii?
o?eueee aaicaoeiiai?oeee?iii. A?iceaiee oaiea? – ia 1,6 aei?; ae?aceiaee
oaiea? – ia 2 aei?; ?icaiea – ia 1,4 aei?; iaioee ia ooeoa? – ia 1,3
aei?; iaioee a ii?iaeiei? ?ioa – ia 0,9 aei?. I?e ii??aiyii? no?ie?a
cieeiaiiy on?o oaiea??a (aeeth/ath/e a?iceai? ? ae?aceia?) a
ii??aithaaieo i?aea?oiao IA ? IA aoee io?eiai? oae? ?acoeueoaoe.
Na?aaei?e no?ie cieeiaiiy oaiea??a o oai?eo, ui iaea?aeoaaee e?eoaaiiy
i?iea?iii o niieo/aii? c aaicaoeiii , aoa ia 1,7 aei? iaioa i?ae o
oai?eo, ui iaea?aeoaaee e?eoaaiiy o?eueee aaicaoei-iai?oeee?iii
(Oaaeeoey 6). No?iee cieeiaiiy iaioe ia aai?oae?yo ? iaioe ia aeieiiyo ?
i?aeioaao aoee i?aeoe/ii iaeiaeiaeie a ii??aithaaieo i?aea?oiao. Cia/eia
i?enei?aiiy cieeiaiiy a iniiai?e i?aea?oi? IA aeyaeaii aeey
?aa?iia?iiai neea?aaeai?oo – ia 3,8 aeiae; oe?ieeo eiiaeeeii – ia 2,2
aeiae ? neo?e?oe/ii? aia?ie – ia 3,8 aeiae. Io?eiai? ?acoeueoaoe iiaeia
?icoe?ieoe ye ia?aaaao cai?iiiiiaaii? iaoiaeeee e?eoaaiiy ?aiiueiai
neo?e?no. Oaeaeea ae?i?iaoe?y caoaeieea i?enei?th? ?ic??oaiiy aeoeaieo
i?iya?a, ye?, ii noo?, ? ?aaeoe??th i?aai?cio ia o?aiiiaie.
Oaaeeoey 6
No?iee cieeiaiiy neo?e?ae?a a i?aea?oiao IA (iniiai?e) ? IA (ii??aiyiiy)
Ee?i?/ia iciaea I?aa?oia IA(aei?) I?aea?oia IA(aei?) ?=
A?iceaiee oaiea? 6,3 SYMBOL 177 \f “Symbol” \s 14 ± 0,9 7,9 SYMBOL
177 \f “Symbol” \s 14 ± 0,8 0,0818
Ae?aceiaee oaiea? 8,0 SYMBOL 177 \f “Symbol” \s 14 ± 0,5 10,0 SYMBOL
177 \f “Symbol” \s 14 ± 1,2 0,0835
An? oaiea?e 7,4 SYMBOL 177 \f “Symbol” \s 13.5 ± 0,6 9,1 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,7 0 ,0157 SYMBOL 42 \f “Symbol” \s 13.5 *
Neea?aaeai?o 15,3 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 19,1(0,9 0 ,0002
SYMBOL 42 \f “Symbol” \s 13.5 *
?icaiea 7,6 SYMBOL 177 \f “Symbol” \s 14 ± 0,6 9,0 SYMBOL 177 \f
“Symbol” \s 14 ± 0,6 0,0561
Iaioee ooeoaa 11,6 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 12,9 SYMBOL 177
\f “Symbol” \s 14 ± 0,9 0,1853
Iaioee a ii?iaeiei? ?ioa 7,1 SYMBOL 177 \f “Symbol” \s 14 ± 0,4 8,0
SYMBOL 177 \f “Symbol” \s 14 ± 0,6 0,0786
Iaioee ia aai?oae?yo 9,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,4 9,3
SYMBOL 177 \f “Symbol” \s 14 ± 0,3 0,1181
Oe?ie? eiiaeeeiie 11,4 SYMBOL 177 \f “Symbol” \s 14 ± 0,8 13,6 SYMBOL
177 \f “Symbol” \s 14 ± 0,8 0 ,0149 SYMBOL 42 \f “Symbol” \s 13.5 *
Iaioee aeieiiue/i?aeioia 13,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,9 13,1
SYMBOL 177 \f “Symbol” \s 14 ± 1,0 0,1331
Aia?ia 8,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 12,6 SYMBOL 177 \f
“Symbol” \s 14 ± 0,7 0 ,0013 SYMBOL 42 \f “Symbol” \s 13.5 *
A?aeaeaeaeai? ?acoeueoaoe e?eoaaiiy aoee i?iaiae?ciaai? o an?o oai?eo ia
i?aenoaa? aeeiai?ee iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e i?e
ee?i?ei-na?ieia?/iiio eiio?ie? aee?eiaaiiino? a?ae 6 aei 18 i?nyoe?a. O
oai?eo, ui iaea?aeoaaee e?eoaaiiy i?iea?i-iai?oeee?iii o niieo/aii? c
aaicaoeiiai?oeee?iii, iaaaoeaaoe?y a?aeaoaa?oueny oaeaeoa ye a oe?eiio a
i?aea?oi?, oae ? c o?aooaaiiyi oi?ie neo?e?no. O an?o oai?eo iniiaii?
i?aea?oie IA iaaaoeaaoe?y ianoaaaea a na?aaeiueiio /a?ac 4,7 i?nyoey, a
a i?aea?oi? ii??aiyiiy IA – /a?ac 6,2 i?nyoey, oiaoi a na?aaeiueiio ia
i?aoi?a i?nyoey oaeaeoa (?=0,0142). Aiaeia?/ia oaiaeaioe?y aeyaey?oueny
? i?e aiae?c? no?ie?a iaaaoeaaoe?? o oai?eo a ii??aithaaieo i?aea?oiao
IA ? IA ie?aii aeey ia?aeiiiai, aoi?eiiiai ? eaoaioiai neo?e?no. Oae, o
oai?eo ia ia?aeiiee neo?e?n iniiaii? a?oie IA iaaaoeaaoe?y ianoaea a
na?aaeiueiio /a?ac 2,8 i?nyoey, a a a?oi? ii??aiyiiy IA – /a?ac 3,7
i?nyoey – ??cieoey i?eaeecii ia 26 aei?a. O oai?eo aoi?eiiei neo?e?nii,
ui iaea?aeoaaee e?eoaaiiy i?iea?i-iai?oeee?iii o niieo/aii? c
aaicaoeiiai?oeee?iii, iaaaoeaaoe?y ianoaea a na?aaeiueiio /a?ac 5,1
i?nyoe?a, a o oai?eo, ui e?eoaaeeny o?eueee aaicaoeiiai?oeee?iii – /a?ac
6,5 i?nyoe?a, oiaoi a na?aaeiueiio ia 40 aei?a iia?euei?oa. (?=0,079).
Iaea?eueoa ae?aci? a?aei?iiino? i?ae iniiaiith i?aea?oiith IA ?
i?aea?oiith ii??aiyiiy niinoa??aaeeny o oai?eo ia eaoaioee neo?e?n. I?e
eaoaioiio neo?e?n? a ?acoeueoao? e?eoaaiiy eiia?iaoe??th
i?iea?i-iai?oeee?io ? aaicaoeiiai?oeee?io, iaaaoeaaoe?y ianoaea a
na?aaeiueiio /a?ac 5 i?nyoe?a, a a ?acoeueoao? e?eoaaiiy o?eueee
aaicaoeiiai?oeee?iii – /a?ac 7,2 i?nyoe?a – oiaoi ??cieoey a?eueo i?ae
ia aeaa i?nyoe? (?=0,037).
Canoinoaaiiy cai?iiiiiaaieo iaie iiaeo e?eoa???a ioe?iee aeeiai?ee
iaaaoeaaoe?? ca aeiiiiiaith ?aa?aneaiiai aiae?co aeicaieeei aeyaeoe
?icoiaeaeaiiy, ui ia niinoa??aaeeny i?e cae/aeiiio ii??aiyii? no?ie?a
iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e. Aiae?c e?eai?, ui a?aeaeaa?
eoioeyoeaiee a?aenioie iaaaoeaaoe?? (iieaciee /anoee oai?eo a
aeine?aeaeoaai?e aea??oe?, o yeeo a?aeaoeany iaaaoeaaoe?y aei aeaiiai
no?ieo), a naia, ioe?iea iaoeeo e?i?? ?aa?an??, ui oa?aeoa?eco?
oaeaee?noue iaaaoeaaoe??, ? ia/eneaiiy ooieoe?? «a?ae??cie», ui
oa?aeoa?eco? no?ie iaaaoeaaoe??, aeicaiey? e?aua i?iaiae?coaaoe
a?aeaeaeai? ?acoeueoaoe e?eoaaiiy. A?ao?/ia a?aeia?aaeaiiy aeeiai?ee
iaaaoeaaoe?? a ii??aithaaieo i?aea?oiao iaei aeaeyae «eoioeyoeaii?
ia?ae» – e?eai? iaeiie/aiiy (iaethiee 3 ? 4). Iaoee e?i?? e?i?eii?
?aa?an??, ui oa?aeoa?eco? ca?eueoaiiy a?aenioea iaaaoeaaoe?? i?ioyaii 14
i?nyoe?a, a iniiai?e i?aea?oi? IA aei??aithaaa 5,3; a a i?aea?oi?
ii??aiyiiy IA – 6,3.
Iae. 3. Aeeiai?ea iaaaoeaaoe?? eiiieaeno na?ieia?/ieo ?aaeoe?e (EN?) o
oai?eo a?oie I (eoioeyoeaiee a?aenioie). IA – oai??, ui iaea?aeoaaee
i?iea?iiai?oeee?i + aaicaoeiiai?oeee?i; IA – oai?? ui iaea?aeoaaee
aaicaoeiiai?oeee?i.
A?eueo ae?aci? ?icoiaeaeaiiy aeyaeythoueny i?e ii??aiyii? i?aea?oi c
o?aooaaiiyi oi?ie neo?e?no. I?e ia?aeiiiio neo?e?n? a iniiai?e i?aea?oi?
? i?aea?oi? ii??aiyiiy iaoee e?i?? ?aa?an?? a?aeiia?aeii 18,2 ? 21,0.
Eiao?oe??io ?aa?an?? aeey ii??aithaaieo i?aea?oi i?e aoi?eiiiio neo?e?n?
oaeee: 7,1 a iniiai?e i?aea?oi? IA ? 8,4 – a i?aea?oi? ii??aiyiiy IA.
I?e eaoaioiio ?aiiueiio neo?e?n? a iniai?e i?aea?oi? oai?eo iaaaoeaaoe?y
a?aeaoaaeany cia/ii oaeaeoa, o ii??aiyii? c i?aea?oiith ii??aiyiiy.
Iaoee e?i?? e?i?eii? ?aa?an?? a?aeiia?aeii 5,8 ? 6,7.
Oaeei /eiii, o oai?eo, ui e?eoaaeeny i?iea?i-iai?oeee?iii o niieo/aii? c
aaicaoei-iai?oeee?iii, iaaaoeaaoe?y eiiieaeno na?ieia?/ieo ?aaeoe?e ia
neo?e?n a?aeaoaaeany oaeaeoa a ii??aiyii? c oai?eie, ui e?eoaaeany
o?eueee aaicaoei-iai?oeee?iii. Oea na?ae/eoue i?i ni?eyoeea? a?aeaeaeai?
?acoeueoaoe aeine?aeaeoaaii? iaoiaeeee ? i?i ?? aenieo aoaeoeai?noue.
Cai?iiiiiaaia iaoiaeeea ? c?o/iith a canoinoaaii? ? iiaea aooe
aeei?enoaia aeey aiaoeaoi?iiai e?eoaaiiy oai?eo ia ?aii?e neo?e?n.
Aoaeoeai?noue e?eoaaiiy oaiien?iaoeeiai?oeee?iii ioe?ithaaeany ii
no?ieao cieeiaiiy aeoeaieo i?iya?a (iaeaeeae/? ?acoeueoaoe) ? ii
aeeiai?oe? iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e (a?aeaeaeai? ?acoeueoaoe).
I?e ii??aiyeueiiio aiae?c? aeaio iaoiae?a e?eoaaiiy aeyaeaii, ui i?e
e?eoaaii? oaiien?iaoeeiai?oeee?iii ie?ai? aeoeai? i?iyae neo?e?no
cieeaee oaeaeoa, i?ae i?e e?eoaaii? aaiceeiai?oeee?iii (Oaaeeoey 7).
A?iceaiee oaiea? – ia 1,2 aei?; ae?aceia? oaiea?e – ia 3 aei?; ?icaiea –
ia 2,3 aei?. I?e ii??aiyii? no?ie?a cieeiaiiy on?o oaiea??a (aeeth/ath/e
a?iceai? ? ae?aceia?) o ii??aithaaieo i?aea?oiao IIA ? IIA aoee io?eiai?
oae? ?acoeueoaoe. Na?aaeisq no?ie cieeiaiiy oaiea??a o oai?eo iniiaii?
i?aeaoie aod ia 2,3 aei? a?eueoa. I?enei?aiiy cieeiaiiy a iniiai?e
i?aea?oi? IIA aeyaeaii oaeiae aeey ?aa?iia?iiai neea?aaeai?oa – ia 2,4
aeiae. Oa?i?ie cieeiaiiy iaioe ia ooeoa? oa iaioe a ii?iaeiei? ?ioa aoee
i?aeoe/ii iaeiaeiaeie a ii??aithaaieo i?aea?oiao – 6-9 aei?a (oaaeeoey
7). Iaioee ia aai?oae?yo o oai?eo, ui e?eoaaeeny
oaiien?iaoeeiai?oeee?iii, cieeaee oaeaeoa a na?aaeiueiio ia 1,6 aei?
i?ae o oai?eo, ui e?eoaaeeny aaiceeiai?oeee?iii. Oe?ie? eiiaeeeiie o
oai?eo iniiaii? i?aea?oie IIA cieeaee a na?aaeiueiio ia 2,5 aei?
oaeaeoa, i?ae o oai?eo a?oia ii??aiyiiy IIA. Neo?e?oe/ia aia?ia
?ic??ooaaeany ca aiaeia?/iee /an o oai?eo iaio i?aea?oi. No?ie
cieeiaiiy aia?ie a?aeiia?aeii 8 ? 10 ae?a. sse aeaeii c oaaeeoe? 7,
oae? i?iyae aoi?eiiiai neo?e?no ye ?icaiea ? iaioee ia aeieiiyo ?
i?aeioaao o oai?eo iniiaii? i?aea?oie ?ic??ooaaeeny a??ia?aeii oaeaeoa,
i?ae o oai?eo i?aea?oie ii??aiyiiy – a?aeiia?aeii ia 2,3 ? 5,4 aeiae.
Aoei i?iaaaeaii ii??aiyeueia aea/aiiy a?aeaeaeaieo ?acoeueoao?a
e?eoaaiiy oaiien?iaoeeiai?oeee?iii ? aaiceeiai?oeee?iii. Aeeiai?ea
iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e a iniiai?e i?aea?oi? IIA ? a
i?aea?oi? ii??aiyiiy IIA ?noioii ia a?ae??ciyeanue. O caaaeueii?
noeoiiino? oai?eo, ui iaea?aeoaaee e?eoaaiiy oaiien?iaoeeiai?oeee?iii,
iaaaoeaaoe?y a?aeaoaaeany a na?aaeiueiio /a?ac 3,6 i?nyoey. O oai?eo, ui
iaea?aeoaaee e?eoaaiiy aaiceeiai?oeee?iii iaaaoeaaoe?y ianoaea a
na?aaeiueiio /a?ac 4,4 i?nyoey ( = 0,0993). Aiaeia?/ia ea?oeia
niinoa??aaeany ? i?e aiae?c? no?ie?a iaaaoeaaoe?? o oai?eo ie?aii aeey
ia?aeiiiai, aoi?eiiiai ? eaoaioiai neo?e?no . Oae o oai?eo ia ia?aeiiee
neo?e?n c iniiaii? i?aea?oie IIA iaaaoeaaoe?y ianoaea a na?aaeiueiio
/a?ac 2 i?nyoey, a o oai?eo c i?aea?oie ii??aiyiiy IIA – /a?ac 2,2
i?nyoey, oiaoi i?aeoe/ii a aiaeia?/i? no?iee (?=0,3437). O oai?eo ia
aoi?eiiee neo?e?n, ui iaea?aeoaaee e?eoaaiiy oaiien?iaoeeiai?oeee?iii,
iaaaoeaaoe?y ianoaea a na?aaeiueiio /a?ac 3,8 i?nyoe?a, a o oai?eo, ui
e?eoaaeeny aaiceeiai?oeee?iii – /a?ac 4,2 i?nyoe?a, oiaoi a
na?aaeiueiio ia 12 aei?a ?ai?oa. O oai?eo ia eaoaioee neo?e?n i?ae
iniiaiith i?aea?oiith IIA ? i?aea?oiith ii??aiyiiy IIA ia aeayeaii
?icoiaeaeaiue o oaeaeeino? iaaaoeaaoee na?ieia?/ieo ?aaeoe?e i?ney
e?eoaaiiy. I?e eaoaioiio neo?e?n? a i?aea?oi? IIA iaaaoeaaoe?y ianoaea a
na?aaeiueiio /a?ac 4 i?nyoey, a a i?aea?oi? IIA – /a?ac 4,2 i?nyoey.
Aeey e?euee?nii? oa?aeoa?enoeee iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e o
ii??aithaaieo i?aea?oiao aoa canoiniaaiee ?aa?aneaiee aiae?c e?eai?, yea
a?aeiath?aaea? eoioeyoeaiee a?aenioie iaaaoeaaoe?? – iieaciee /anoee
oai?eo a aeine?aeaeoaai?e aea??oe?, o yeeo a?aeaoeany iaaaoeaaoe?y aei
aeaiiai no?ieo. Iaoee e?i?? ?aa?an??, ui oa?aeoa?eco? ia?inoaiiy
a?aenioea iaaaoeaaoe??, a iniiai?e i?aea?oi? IIA aei??aithaaa 7,2; a a
i?aea?oi? ii??aiyiiy – IIA – 7,4 oiaoi i?aeoe/ii ia a?ae??ciyany. I?e
ii??aiyii? i?aea?oi c o?aooaaiiyi oi?ie neo?e?no ?noioieo ?icoiaeaeaiue
i?ae ieie o oaeaeeino? iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e oaeiae ia
aeyaey?oueny. I?e ia?aeiiiio neo?e?n? a iniiai?e i?aea?oi? ? i?aea?oi?
ii??aiyiiy iaoee e?i?? ?aa?an?? a?aeiia?aeii 35,5 ? 40,0. Eiao?oe??io
?aa?an?? aeey ii??aithaaieo i?aea?oi IIA ? IIA i?e aoi?eiiiio neo?e?n?
oaeee: – 9,5 a iniiai?e i?aea?oi? IIA ? 9,2 – a i?aea?oi? ii??aiyiiy
IIA. I?e eaoaioiio ?aiiueiio neo?e?n? a i?aea?oi? oai?eo, ui e?eoaaeeny
oaiien?iaoeeiai?oeee?iii, ? i?aea?oi? ii??aiyiiy, ui e?eoaaeany
aaiceeiai?oeee?iii, aeeiai?ea iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e ?noioii
ia a?ae??ciyeanue. Iaoee e?i?? e?i?eii? ?aa?an?? a?aeiia?aeii 8,0 ? 8,7.
Oaaeeoey 7
No?iee cieeiaiiy neo?e?ae?a a i?aea?oiao IIA (iniiaii?) ? IIA
(ii??aiyiiy)
Ee?i?/ia iciaea I?aea?oia IIA
(aei?) I?aea?oia IIA
Iae. 4. Aeeiai?ea iaaaoeaaoe?? eiiieaeno na?ieia?/ieo ?aaeoe?e (EN?) o
oai?eo a?oie II (eoioeyoeaiee a?aenioie). IIA – oai??, ui iaea?aeoaaee
iaaaoeeeeei; IIA – oai?? ui iaea?aeoaaee, aaiceeiai?oeee?i.
?acoeueoaoe, io?eiai? i?e aea/aiiu iaeaeeae/eo oa auaeaeaeaieo
?acoeueoao?a e?eoaaiiy a i?aea?oiao IIA ? IIA iiaeia ?icoe?ieoe ye
i?aeoaa?aeaeaiiy aoaeoeaiino? iaio iaoiaeee. Ia?aaaaith cai?iiiiiaaii?
iaoiaeeee e?eoaaiiy ?aiiueiai neo?e?no oaiien?iaoeeiai?oeee?iii ?
c?o/i?noue o canoinoaaii?. I?e oeueiio ?iaeoueny iaeia ?i’?eoe?y ia
aeiao, a ia a?n?i, ye i?e iaoiaeeoe? ii??aiyiiy. E??i oiai, noia?ia
aeica iai?oeee?io a /ioe?e ?ace iaioa i?e aeei?enoaii?
oaiien?iaoeeiai?oeee?io.
AENIIAEE
Oai?ei ia ?aii?e neo?e?n i?eoaiai? eaoaioee ia?aa?a caoai?thaaiiy
(38,6%) ? iiaeiaaeaiiy ?ieoaaoe?eiiai ia??iaeo (29 SYMBOL 177 \f
“Symbol” \s 13.5 ± 1 aei?a). Aeoeaiee neo?e?n ia?aa?aa? c? neaaeith
ae?aci?noth ?aa?iia?iiai e?ioaaeai?oo (1,5 SYMBOL 177 \f “Symbol” \s
13.5 ± 0,1 ni); aenieith /anoioith neo?e?oe/ii? aia?ie (78,5%), iaioe ia
neeciaeo iaieiieao ii?iaeieie ?ioa (61,5%) ? aai?oae?e (67%); a oaeiae
c a?aeiinii iecueeith /anoioith iaioe ia ooeoa? (53%). Noiooiuey
niiaoe/ia iaoieia?y niinoa??aa?oueny o 32% oai?eo ia ?aii?e neoee?n.
Anoaiiaeaii, ui /anoioa noiooiuei? iaoieia?? caeaaeeoue a?ae ?aa?iio
iaoeaiiy oai?eo, oiae? ye /anoioa ie?aieo ee?i?/ieo i?iya?a neo?e?no
a?ae i?noey i?iaeeaaiiy oai?eo ia caeaaeaoue.
Aaaaeaiiy aioo??oiueii’yciai 2,4 iei. IAe i?iea?i-iai?oeee?io a
niieo/aii? c 2,4 iei. IAe aaicaoei-iai?oeee?io ni?ey? oaeaeeiio
iane/aiith aaiceeiai?oeee?iii ne?iaaoee e?ia? (8,5 SYMBOL 177 \f
“Symbol” \s 13.5 ± 1,2 iea/ie /a?ac 1 aiaeeio; 0,3 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,0,1 iea/ie /a?ac aeiao) ? caa??aaiith
o?aiiiaiaoeeaeii? eiioeaio?aoe?? i?ioyaii 7 ae?a (0,06 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,01 iea/ie). Iaeaeeae/? ? a?aeaeaeai? ?acoeueoaoe
na?ae/aoue i?i aoaeoeai?noue e?eoaaiiy oai?eo ia ?aii?e neo?e?n ca
aeaiith iaoiaeeeith. Oaa?aeee oaiea? cieea? ca 7,4 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,6 aei?; ?aa?iia?iee e?ioaaeai?oe – ca 15,3 SYMBOL
177 \f “Symbol” \s 14 ± 0,7 aei?; ?icaiea – ca 7,6 SYMBOL 177 \f
“Symbol” \s 14 ± 0,6 aei?; iaioee ia ooeoa?, o ii?iaeiei? ?ioa ? ia
aai?oae? yo – a?aeiia?aeii ca 11,6 0,7, 7,1 SYMBOL 177 \f “Symbol” \s 14
± 0,4 ? ca 9,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,4 aei?. Oe?ie?
eiiaeeeiie – ca 11,4 SYMBOL 177 \f “Symbol” \s 14 ± 0,8 aei?; iaioee
aeieiiue ? i?aeioia – ca 13,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,9 aei?;
aia?ia ca – 8,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 aei?. O oai?eo ia
ia?aeiiee neo?e?n iaaaoeaaoe?y na?ieia?/ieo ?aaeoe?e ianoa? /a?ac 2,8
SYMBOL 177 \f “Symbol” \s 14 ± 0,4 i?nyoey; ia aoi?eiiee neo?e?n – /a?ac
5,1 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 i?nyoey; o oai?eo ia ?aii?e
eaoaioee neo?e?n – /a?ac – 5,0 SYMBOL 177 \f “Symbol” \s 14 ± 0,7
i?nyoey.
Aaaaeaiiy 2 iei. IAe oaiien?iaeeiai?oeee?io aioo??oiueii’yciai noai?th?
aenieo eiioeao?ioeeth oaiien?iaoeeiai?oeee?io a ne?iaaooe? e?ia? (28,8
SYMBOL 177 \f “Symbol” \s 13.5 ± 2,3 iea/ie /a?ac 1 aiaeeio; 0,8 SYMBOL
177 \f “Symbol” \s 13.5 ± 0,02 iea/ie /a?ac 12 aiaeei) ? caa??aaiith
o?aiiiaiaoeeaeii? eiioeaio?aoe?? i?ioyaii aeiae (0,06 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,02 iea/ie). Iaeaeeae/? ? a?aeaeaeai? ?acoeueoaoe
na?ae/aoue i?i aoaeoeai?noue e?eoaaiiy oai?eo ia ?aii?e neo?e?n ca
aeaiith iaoiaeeeith. Oaa?aeee oaiea? cieea? ca 4,1 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,4 aei?; ?aa?iia?iee e?ioaaeai?oe – ca 8,8 SYMBOL
177 \f “Symbol” \s 13.5 ± 0,7 aei?; ?icaiea – ca 6,5 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,5 aei?; iaioee ia ooeoa?, o ii?iaeiei? ?ioa ? ia
aai?oae?yo – a?aeiia?aeii ca 8,2 SYMBOL 177 \f “Symbol” \s 13.5 ± 0,6
5,7 SYMBOL 177 \f “Symbol” \s 13.5 ± 0,3 ? ca 8,4 SYMBOL 177 \f “Symbol”
\s 13.5 ± 0,7 aei?. Oe?ie? eiiaeeeiie – ca 11,8 SYMBOL 177 \f “Symbol”
\s 13.5 ± 0,9 aei?; iaioee aeieiiue ? i?aeioia – ca 11,3 SYMBOL 177 \f
“Symbol” \s 13.5 ± 0,5 aei?; aia?ia ca – 8,3 SYMBOL 177 \f “Symbol” \s
13.5 ± 0,6 aei?. O oai?eo ia ia?aeiiee neo?e?n iaaaoeaaoe?y na?ieia?/ieo
?aaeoe?e ianoa? /a?ac 2,0 SYMBOL 177 \f “Symbol” \s 14 ± 0,3 i?nyoey;
ia aoi?eiiee neo?e?n – /a?ac 3,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,5
i?nyoey; ia ?aii?e eaoaioee – /a?ac – 4,0 SYMBOL 177 \f “Symbol” \s 14
± 0,5 i?nyoey.
Cai?iiiiiaaii iiaee iaoiae e?euee?nii? ioe?iee a?aeaeaeaieo ?acoeueoao?a
e?eoaaiiy a?oie oai?eo ia neo?e?n ia iniia? aiae?co eoioeyoeaiiai
a?aenioea iaaaoeaaoe?? na?ieia?/ieo ?aaeoe?e – oiaoi a?aenioea oai?eo, o
yeeo a?aeaoeany iaaaoeaaoe?y aei aeaiiai no?ieo. I?e oeueiio
i?iaiaeeoueny ?aa?aneaiee aiae?c e?i??, ui a?aeaeaa? ci?io eoioeyoeaiiai
a?aenioea i?ioyaii /ano. Ia/eneththoueny ooieoe?? «iaoee e?i?? ?aa?an??»
– oaeaee?noue ci?ie cia/aiue ocaeiaae in? /ano ? «a?ae??cie» –
a?aenoaiue aei oi/ee ia?aoeio e?i?? ?aa?an?? c a?nnth /ano. Io?eiai?
?acoeueoaoe oa?aeoa?ecothoue oaeaee?noue ? o?eaae?noue iaaaoeaaoe??
na?ieia?/ieo ?aaeoe?e a aeai?e a?oi? oai?eo.
I?iiiiothoueny iia? iaoiaee e?eoaaiiy oai?eo ia ?aii?e neo?e?n (no?ie
ca?aaeaiiy aei 1 ?ieo), aeey canoinoaaiiy a oiiaao aiaoeaoi??? aai
aeaiiiai noaoe?iia?o.
A. I?iea?i-iai?oeee?i (2,4 i?eueeiie IAe) a iaeio n?aeieoeth,
aaicaoeiiai?oeee?i (2,4 i?eueeiie IAe) – a ?ioo n?aeieoeth iaeii?aciai
(i?aaaioeaia e?eoaaiiy, neo?e?n ia?aeiiee); /a?ac 7 aei?a ae?oaa
?i’?eoe?y 2,4 i?eueeiie IAe aaicaoei-iai?oeee?io, a /a?ac 7 aei?a o?aoy
?i’?eoe?y 2,4 i?eueeiie IAe aaicaoei-iai?oeee?io (neo?e?n aoi?eiiee,
neo?e?n eaoaioee ?aii?e).
A. Oaiien?iaoeeiai?oeee?i ii 2 i?eueeiie IAe aioo??oiueii’yciai 1 ?ac ia
aeaiue (i?aaaioeaia e?eoaaiiy, neo?e?n ia?aeiiee – 7 aei?a; neo?e?n
aoi?eiiee – 14 aei?a; neo?e?n ?aii?e eaoaioee – 18 aei?a).
NIENIE IIOAE?EIAAIEO I?AOeUe CAeIAOAA*A
CA OAIITH AeENA?OAOe??
Iaiaaeee I. I. Iiuo i?eiaiaiey yenoaioeeeeeia aeey ea/aiey ?aiieo oi?i
neoeeena // AEo?iae aea?iaoieiaee e aaia?ieiaee.- ? 2(4).-
Oa?ueeia,1997.- N.82-84.
Iaa?ia A.E., Aiiaea?aiei A.I., Iaiaaeee I.I. Nia?aiaiiua iniaaiiinoe
neoeeena: eaai?aoi?iay aeeaaiinoeea a iaiauo oneiaeyo // AEo?iae
aea?iaoieiaee e aaia?ieiaee.- ? 1(5).- Oa?ueeia,1998.- N.8-12.
Iaa?ia A.E., Iaiaaeee I.I. Iiaua iiaeoiaeu e ea/aieth neoeeena //
Aea?iaoiaaia?ieiaey, einiaoieiaey e naeniiaoieiaey (Aeiai?iiao?iane).-
1998 ?1.- N.130- 132.
Iaa?ia A.E., Aoaaiei O.A., Aiiaea?aiei A.I., Iaiaaeee I.I., Iao?aoaiei
I.?. I?eioeeie ao?io?iiiiai e?eoaaiiy neo?e?no // E?e?.- 1998.-
?.4.-N.54-58.
Iaa?ia A.E., Aoaaiei O.A., Aiiaea?aiei A.I., Iaiaaeee I.I. I?eioeeie
ao?io?iiiiai e?eoaaiiy neo?e?no // AEo?iae aea?iaoieiaee e aaia?ieiaeee
(Oa?ueeia).- 1999.- ? 1 (7).- C. 64-67.
Iaa?ia A.E., Iaiaaeee I.I. Iaaaoeee?i ye ao?io?iiie e aaaio e?eoaaiiy
neo?e?no // Oe?a?inueeee iaaee/iee aeueiaiao.- 1999.- Oii 2.-
?1(Aeioaoie).-N.73-74.
«Niin?a ioe?iee ?acoeueoao?a e?eoaaiiy oai?eo ia ?aii? oi?ie neo?e?no.
Cayaea ia aeiao?ae. I??i??oaoia aeia?aeea ? 99063323, a?ae 15.06.1999 ?.
Iaa?ia A.E., Aiiaea?aiei A.I., Iaiaaeee I.I. I?eioeeiu yoeio?iiiiai
ea/aiey neoeeena ia nia?aiaiiii yoaia // Caoai?thaaiiy, ui
ia?aaeathoueny noaoaaei oeyoii. Oac. Eiio.Eeaa, 1998.- 88 n.- N. 50.
Iaa?ia A.E., Iaiaaeee I.I . Iaaaoeeeeei eae n?aaenoai ea/aiea ?aiieo
oi?i neoeeena. Oac. aeii.VII Oe?a?inueeiai c’?caeo aea?iaoiaaia?ieia?a
(7-10 aa?aniy 1999 ?., i. Ee?a).- N.111.
A.E Iaa?ia I.I. Iaiaaeee Eiiaeie?iaaiiia i?eiaiaiea aeth?aioiuo e
aiaei?anoai?eiuo i?aia?aoia iaieoeeeeeia o nioeeaeueiai-iaaeaaiiieo/iiai
eioeiaaioa // Iiaia a iaoea e i?aeoeea (Iaeanna).- 1998.-?.2.-N.38
Iaa?ia A.E., Iaiaaeee I.I. No/ani? i?eioeeie e?eoaaiiy neo?e?no //
Oi?noaaneea /oaiey. Na. iao/i. I?aeo. ?aaio. IAAeEIOI: Aeiiaoee, 1999-
N.124-126.
Iaa?ia A.E., Iaiaaeee I.I. E?eoaaiiy ?aii?o oi?i neo?e?no iaaaoeee?iii
// Aeooaeuei? ieoaiiy aea?iaoiaaia?ieia??. Aeione 12. Aei?i?iiao?ianuee,
1999.- N.282-284.
Iaa?ia A.E., Aiiaea?aiei A.I., Iaiaaeee I.I. Oeueo?ano?oeoo?i?e
iaoiaaiac ?aiiaai aeoeaiiai neoeeena: acaeiiaeaenoaea TREPONEMA
PALLIDUM n eeaoeaie-ieoaiyie e eiioiieiiiaoaioi?ie eeaoeaie // AEo?iae
aea?iaoiaaia?ieiaee e einiaoiaeiaee (Naeo-Ieoa?ao?a) 1998.- ?2.-N.55-59.
Ae.Ae.Aaaeeoeaa, I.I Iaiaaeee, A.I. Iaiaaeia ?.?. Aonaeiia .Iiuo
i?eiaiaiey i?ieaei-iaieoeeeeeia e yenoaioeeeeeia i?e ea/aiee ?aiieo oi?i
neoeeena // NaFeoieua – Caei?iauea-Aaeo,1998.-?.10.-N.27-30.
Ae.Ae.Aaaeeoeaa, I.i. Iaiaaeee, A.I. Iaiaaeia Nia?aiaiiia ninoiyiea e
i?iaeaiu, naycaiiua n i?eiaiaieai aaeoeeiu i?ioea neoeeena
Dermatovenerologiynin Azerbaaycanda Muasir» Nailiyyetlery» professor
I.M. Ismaiyilzadenin 100 illik yubilleyne hesr olunmus.- Baki, 1998.-
N.93-98.
Ea/aiea ?aiiaai neoeeena n i?eiaiaieai aeth?aioiuo e aiaei-?anoai?eiuo
i?aia?aoia iaieoeeeeeiiaiai ?yaea. Iaa?ia A.E., Iaiaaeee I.I., Eei/ei
A.A. Iaoiaee/aneea ?aeiiaiaeaoeee aeey aea?iaoiaaia?ieiaia.-. Oe?aeineee
IEE aea?iaoieiaee e aaia?ieiaee IIC Oe?aeiu, Oa?ueeia, 1998 a. 6 n.
AIIOAOe??
Iaiaaee? I.I. E?eoaaiiy oai?eo ia ?aii?e neo?e?n ii?aeiaiei
canoinoaaiiyi i?iea?i-iai?oeee?io ? aaicaoei-iai?oeee?io a oaeiae
oaiien?iaoeeiai?oeee?io (ee?i?ei-eaai?aoi?ia aeine?aeaeaiiy). ?oeiien.
Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.20 – oe??i? oa aaia?e/i? oai?iae.–
Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo aea?iaoieia?? oa aaia?ieia??,
Oa?e?a, 1999.
Aeena?oaoe?th i?enay/aii ?ic?iaoe? iaoiae?a e?eoaaiiy oai?eo ia ?aii?
oi?ieAneo?e?no i?iea?i-iaieoeeeeeiii o niieo/aii? c
aaicaoei-iai?oeee?iii, a oaeiae oaiien?iaoeeiaieoeeeeeiii c o?aooaaiiyi
iniaeeainoae ee?i?ee, iaoiaaiaco caoai?thaaiiy ? oa?iaeioa?aiaaoe/ieo
aeanoeainoae oeeo i?aia?ao?a. Aea/aii ee?i?/i? iniaeeaino? oa oa?aeoa?
ia?aa?ao ?aiiueiai neo?e?na ia no/aniiio aoai? o oai?eo, ui iaoeathoue o
??ciiiai?oieo aaia?ao?/ieo ciiao. Aecia/aii oa?iaeieeiaoe/i? iniaeeaino?
i?iea?i-iaieoeeeeeio ? aaicaoei-iaieoeeeeeio, a oaeiae
oaiien?iaoeeiaieoeeeeeio i?e e?eoaaii? oai?eo i neo?e?n. I?iaaaeaii
ii??aiyeueiee aiae?c iaeaeeae/eo ? a?aeaeaeaieo ?acoeueoao?a e?eoaaiiy
oai?eo ia neo???n ?c canoinoaaiiyi i?iea?i-iaieoeeeeeio ?
aaicaoei-iaieoeeeeeio, a oaeiae oaiien?iaoeeiaieoeeeeeio. Cai?iiiiiaaii
iia? aoaeoeai? ? c?o/i? iaoiaee e?eoaaiiy oai?eo ia ?aiie oi?ie
neo?e?no aeey canoinoaaiiy a i?aeoe/i?e ioi?ii? caei?ia’y ? ?ic?iaeai?
e?eoa??? ioe?iee ?oiuei? aoaeoeaiino?. Eeth/ia? neiaa: neo?e?n,
e?eoaaiiy, i?iea?i-iai?oeee?i, aaicaoei-iai?oeee?i,
oaiien?iaoeeiai?oeee?i
Iaiaaeee I.I. Ea/aiea aieueiuo ?aiiei neoeeenii ni/aoaiiui i?eiaiaieai
i?ieaei-iaieoeeeeeia e aaicaoei-iaieoeeeeeia, a oaeaea
oaiieneiaoeeiaieoeeeeeia (eeeieei-eaai?aoi?iia enneaaeiaaiea) ?oeiienue
Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.20 – eiaeiua e aaia?e/aneea aieacie.–
Oe?aeineee iao/ii-enneaaeiaaoaeueneee einoeooo aea?iaoieiaee e
aaia?ieiaee, Oa?ueeia, 1999.
Neoeeen inoaaony iaeiie ec iaeaieaa ?ani?ino?aiaiiuo eioaeoeeiiiuo
aieaciae ai iiiaeo no?aiao. Oeaeueth aeaiiie ?aaiou auei ?ac?aaioaoue
iiaua iaoiaeu ea/aiey aieueiuo ?aiieie oi?iaie neoeeena
i?ieaei-iaieoeeeeeiii a ni/aoaiee n aaicaoei-iaieoeeeeeiii, a oaeaea
oaiieneiaoeeiaieoeeeeeiii n o/aoii iniaaiiinoae eeeieee, iaoiaaiaca
caaieaaaiey e oa?iaeioa?aiaaoe/aneeo naienoa yoeo i?aia?aoia. Auee
eco/aiu eeeie/aneea iniaaiiinoe e oa?aeoa? oa/aiey ?aiiaai neoeeena ia
nia?aiaiiii yoaia o aieueiuo, i?iaeeaathueo a ?acee/iuo aaia?aoe/aneeo
ciiao. Ii?aaeaeaiu oa?iaeieeiaoe/aneea iniaaiiinoe i?ieaei-iaieoeeeeeia
e aaicaoei-iaieoeeeeeia, a oaeaea oaiieneiaoeeiaieoeeeeeia i?e ea/aiee
aieueiuo neoeeenii. I?iaaaeai n?aaieoaeueiue aiaeec aeeaeaeoeo e
ioaeaeaiiuo ?acoeueoaoia ea/aiey aieueiuo neoeeenii n i?eiaiaieai
i?ieaei-iaieoeeeeeia e aaicaoei-iaieoeeeeeia, a oaeaea
oaiieneiaoeeiaieoeeeeeia. I?aaeeiaeaiu iiaua yooaeoeaiua e oaeiaiua
iaoiaeu ea/aiey aieueiuo ?aiieie oi?iaie neoeeena aeey i?eiaiaiey a
i?aeoe/aneii cae?aaiio?aiaiee e ?ac?aaioaiu e?eoa?ee ioeaiee eo
yooaeoeaiinoe. Onoaiiaeaii, /oi o aieueiuo ?aiiei neoeeenii oa?aeoa?ii
iaee/ea niioonoaothuae niiaoe/aneie iaoieiaee (32%), ne?uoia oa/aiea
neoeeena (38,6%), oaeeeiaiea eieoaaoeeiiiiai ia?eiaea (29 SYMBOL 177 \f
“Symbol” \s 13 ± 1 aeiae). Aeoeaiue neoeeen i?ioaeaao ni neaaie
au?aaeaiiinoueth ?aaeiia?iiai eeioaaeaieoa (1,5 SYMBOL 177 \f “Symbol”
\s 13 ± 0,1ni); aunieie /anoioie neoeeeoe/aneie aiaeiu (78,5%), iaioe ia
neecenouo iaiei/eao iieinoe ?oa (61,5%) e aaieoaeee (67%); ieceie
/anoioie iaioe ia ooeiaeua(53%). I?e n?aaiaiee aeaoo a?oii aieueiuo
?aiiei neoeeenii, i?iaeeaathueo a a. Oa?ueeiaa e a a. Aaeo, onoaiiaeaii,
/oi /anoioa e aeae niioonoaothuae iaoieiaee caaenyo io ?aaeiia
i?iaeeaaiey aieueiuo, oiaaea eae oa?aeoa? oa/aiey e ano?a/aaiinoue
ioaeaeueiuo eeeie/aneeo i?iyaeaiee neoeeena io ianoa aeeoaeuenoaa
aieueiuo ia caaenyo. Aaaaeaiea 2,4 iei. AAe i?ieaei-iaieoeeeeeia a
ni/aoaiee n 2,4 iei. AAe aaicaoei-iaieoeeeeeia niinianoaoao auno?iio
ianuuaieth aaiceeiaieoeeeeeiii nuai?ioee e?iae (8,5 SYMBOL 177 \f
“Symbol” \s 13 ± 1,2 iea/ie /a?ac 1 /an; 0,3 SYMBOL 177 \f “Symbol” \s
13 ± 0,0,1 iea/ie /a?ac nooee) e nio?aiaieth o?aiiiaiaoeeaeiie
eiioeaio?aoeee a oa/aiea 7 nooie (0,06 SYMBOL 177 \f “Symbol” \s 13 ±
0,01 iea/ie). Aeeaeaeoea e ioaeaeaiiua ?acoeueoaou naeaeaoaeuenoaotho ia
yooaeoeaiinoe ea/aiey aieueiuo ?aiiei neoeeenii ii aeaiiie iaoiaeeea.
Oaa?aeue oaie? ?ac?aoaaony ca 7,4 SYMBOL 177 \f “Symbol” \s 13 ± 0,6
aeiy; ?aaeiia?iue eeioaaeaieo – ca 15,3 SYMBOL 177 \f “Symbol” \s 14 ±
0,7 aeiy; ?icaiea – ca 7,6 SYMBOL 177 \f “Symbol” \s 14 ± 0,6 aeiy;
iaioeu ia ooeiaeua, a iieinoe ?oa e ia aaieoaeeyo – niioaaonoaaiii ca
11,6 SYMBOL 177 \f “Symbol” \s 14 ± 0,7, 7,1 SYMBOL 177 \f “Symbol” \s
14 ± 0,4 e ca 9,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,4 aeiy. Oe?ieea
eiiaeeeiiu – ca 11,4 SYMBOL 177 \f “Symbol” \s 14 ± 0,8 aeiy; iaioeu
eaaeiiae e iiaeioa – ca 13,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,9 aeiy;
aiaeia ca – 8,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 aeiy. O aieueiuo
ia?ae/iui neoeeenii iaaaoeaaoeey na?ieiae/aneeo ?aaeoeee ianooiaao /a?ac
2,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,4 ianyoea; aoi?e/iui neoeeenii –
/a?ac 5,1 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 ianyoea; ?aiiei ne?uoui –
/a?ac – 5,0 SYMBOL 177 \f “Symbol” \s 14 ± 0,7 ianyoea. Aaaaeaiea 2 iei.
AAe oaiieneiaeeiaieoeeeeeia aioo?eiuoa/ii nicaeaao aunieoth
eiioeao?ioeeth oaiieneiaoeeiaieoeeeeeia a nuai?ioea e?iae (28,8 SYMBOL
177 \f “Symbol” \s 13 ± 2,3 iea/ie /a?ac 1 /an; 0,8 SYMBOL 177 \f
“Symbol” \s 13 ± 0,02 iea/ie /a?ac 12 /ania) e nio?aiaieth
o?aiiiaiaoeeaeiie eiioeaio?aoeee a oa/aiea nooie (0,06 SYMBOL 177 \f
“Symbol” \s 13 ± 0,02 iea/ie). Aeeaeaeoea e ioaeaeaiiua ?acoeueoaou
naeaeaoaeuenoaotho ia yooaeoeaiinoe ea/aiey aieueiuo ?aiiei neoeeenii ii
aeaiiie iaoiaeeea. Oaa?aeue oaie? ?ac?aoaaony ca 4,1 SYMBOL 177 \f
“Symbol” \s 13 ± 0,4 aeiy; ?aaeiia?iue eeioaaeaieo – ca 8,8 SYMBOL 177
\f “Symbol” \s 13 ± 0,7 aeiy; ?icaiea – ca 6,5 SYMBOL 177 \f “Symbol” \s
13 ± 0,5 aeiy; iaioeu ia ooeiaeua, a iieinoe ?oa e ia aaieoaeeyo –
niioaaonoaaiii ca 8,2 SYMBOL 177 \f “Symbol” \s 13 ± 0,6 5,7 SYMBOL 177
\f “Symbol” \s 13 ± 0,3 e ca 8,4 SYMBOL 177 \f “Symbol” \s 13 ± 0,7
aeiy. Oe?ieea eiiaeeeiiu – ca 11,8 SYMBOL 177 \f “Symbol” \s 13 ± 0,9
aeiy; iaioeu eaaeiiae e iiaeioa – ca 11,3 SYMBOL 177 \f “Symbol” \s 13 ±
0,5 aeiy; aiaeia ca – 8,3 SYMBOL 177 \f “Symbol” \s 13 ± 0,6 aeiy. O
aieueiuo ia?ae/iui neoeeenii iaaaoeaaoeey na?ieiae/aneeo ?aaeoeee
ianooiaao /a?ac 2,0 SYMBOL 177 \f “Symbol” \s 14 ± 0,3 ianyoea;
aoi?e/iui neoeeenii – /a?ac 3,8 SYMBOL 177 \f “Symbol” \s 14 ± 0,5
ianyoea; ?aiiei ne?uoui – /a?ac – 4,0 SYMBOL 177 \f “Symbol” \s 14 ± 0,5
ianyoea. I?aaeeiaeai iiaue iaoiae eiee/anoaaiiie ioeaiee ioaeaeaiiuo
?acoeueoaoia ea/aiey a?oiiu aieueiuo neoeeenii ii aeaiiie iaoiaeeea ia
iniiaa aiaeeca eoioeyoeaiiai i?ioeaioa – o.a. i?ioeaioa aieueiuo, o
eioi?uo i?iecioea iaaaoeaaoeey na?ieiae/aneeo ?aaeoeee e aeaiiiio n?ieo.
I?e yoii i?iaiaeeony ?aa?anneaiue aiaeec eeiee, io?aaeathuae eciaiaiea
eoioeyoeaiiai i?ioeaioa ai a?aiaie. Au/eneyaony ooieoeee «iaeeii eeiee
?aa?annee» – nei?inoue eciaiaiey cia/aiee aaeieue ine a?aiaie e
«io?acie» – aeeeio ?annoiyiey aei oi/ee ia?ana/aiey eeiee n inueth
a?aiaie. Iieo/aiiua ?acoeueoaou oa?aeoa?ecotho nei?inoue e
aeeeoaeueiinoue iaaaoeaaoeee a aeaiiie a?oiia aieueiuo. ?aeiiaiaeothony
iiaua iaoiaeu ea/aiey aieueiuo ?aiiei neoeeenii (n?ie ca?aaeaiey aei 1
aiaea), i?eiaieiua a oneiaeyo aiaoeaoi?ee eee aeiaaiiai noaoeeiia?a.
I?ieaei-iaieoeeeeei a iaeio yaiaeeoeo, aaicaoeiiaieoeeeeei 2,4
ieeeeiia AAe – a ae?oaoth yaiaeeoeo iaeii?aciai (i?aaaioeaiia ea/aiea,
neoeeen ia?ae/iue); /a?ac 7 aeiae iiaoi?iay eiuaeoeey 2,4 ieeeeiia
AAe aaicaoei-iaieoeeeeeia (neoeeen aoi?e/iue naaaeee); /a?ac 7 aeiae
o?aouey eiuaeoeey 2,4 ieeeeiia AAe aaicaoei-iaieoeeeeeia (neoeeen
aoi?e/iue ?aoeeaeeaiue, neoeeen ne?uoue ?aiiee). Oaiieneiaoeeiaieoeeeeei
ii 2 ieeeeiia AAe aioo?eiuoa/ii 1 ?ac a aeaiue (i?aaaioeaiia ea/aiea,
neoeeen ia?ae/iue – 7 aeiae; neoeeen aoi?e/iue naaaeee – 14 aeiae;
neoeeen aoi?e/iue ?aoeeaeeaiue e ?aiiee ne?uoue – 18 aeiae). Eeth/aaua
neiaa: neoeeen, ea/aiea, i?ieaei-iaieoeeeeei, aaicaoei-iaieoeeeeei,
oaiieneiaoeeiaieoeeeeei
Mamedli M.M. Treatment of pataents with early syphilis by combined
application of procaine penicillin & benzatin penicillin and also
phenoxymethylpenicillin (clinical and laboratory research)
Manuscript.Thesis for a candidate of medical science degree in
speciality of 14.01.20 – skin and venereal diseases.– Ukrainian Research
Institute for Dermatology and Venereology, Kharkov, 1999.
The thesis is dedicated to development of treatment methods for the
patients with the early syphilis by procaine penicillin in a combination
with benzatin penicillin, and also by phenoxymethylpenicillin in view of
clinic, pathogenesis of the disease and pharmacotheraputic properties of
these medications. The clinical features and character of current early
syphilis in patients living in various geographical zones are
investigated. Certain pharmacokinetic properties of procaine penicillin
and benzatin penicillin, and also phenoxymethylpenicillin at treatment
of the patients with syphilis were determined. The comparative analysis
of the nearest and remote results of treatment of the patients is
carried out. The new effective and convenient methods of treatment of
the patients by the early forms of syphilis are developed. These methods
can be applied in public health servaces New criteria for an estimation
of their efficiency are proposed. Key words: syphilis, treatment,
procaine penicillin, benzatin penicillin, phenoxymethylpenicillin
A??ia?aei?noue a?ae??ciaiiy
SYMBOL 42 \f “Symbol” \s 12 * A?ae??ciaiiy a??ia?aei?
Cia/aiiy 4,8 aeey ia?oi? aeiae; cia/aiiy 120 – aeey 2-7 ae?a.
SYMBOL 42 \f “Symbol” \s 10 * A?ae??ciaiiy a??ia?aei?
SYMBOL 42 \f “Symbol” \s 10 * A?aei?iiino? a??ia?aei?
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