.

Перебіг гломерулонефриту в умовах цитомегаловірусної інфекції: Автореф. дис… канд. мед. наук / С.М. Артемова, Харк. держ. мед. ун-т. — Х., 1999. — 1

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OA?E?ANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

A?OAIIAA Na?oeaia Ieeiea?aia

OAeE 616.611-002-022.6-036-08

IA?AA?A AEIIA?OEIIAO?EOO A OIIAAO

OeEOIIAAAEIA??ONII? ?IOAEOe??

14.01.02 – aioo??oi? oai?iae

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?e?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
IIC Oe?a?ie.

Iaoeiaee ea??aiee aeieoi? iaaee/ieo iaoe, i?ioani?

Naieaeioeueea AEaiia Aeieo??aia,

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/ea eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia ? 2

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, aeioeaio

Aeanaiei Ieoaeei Aioiiiae/,

Oa?e?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe,

caa?aeoaa/ eaoaae?e oa?ai?? oa iao?ieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

Aieueoeaa Aiaoie?e Ieeieaeiae/,

?inoeooo i?iaeai e??ia?ieia?? oa e??iiaaeeoeeie IAI Oe?a?ie,

caa?aeoaa/ a?aeae?eo e??iiaoio?c?ieia??.

I?ia?aeia onoaiiaa ?inoeooo o?ieia?? oa iao?ieia?? AII Oe?a?ie,
a?aeae?e oa?aiaaoe/ii? iao?ieia??.

Caoeno a?aeaoaeaoueny “ 9 ” aa?aciy 2000 ?.,

i1230 aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04
i?e Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ca aae?anith:
310022, i. Oa?e?a, i?iniaeo Eai?ia, 4.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (aae?ana: 310022, i. Oa?e?a,
i?iniaeo Eai?ia, 4)

Aaoi?aoa?ao ?ic?neaiee “7” ethoiai 2000 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, eaiaeeaeao iaaee/ieo iaoe,

aeioeaio
E.?.Ia/a?aiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE.

Aeooaeuei?noue oaie. I?iaeaie ?inoo caoai?thaaiue ie?ie oa ci?ie ?o
ia?aa?ao, oaeaeeiai ?icaeoeo neea?ioe/ieo i?ioean?a, ?acenoaioiino? aei
canoiniaaii? oa?ai?? noaee o inoaii? ?iee oeaio?aeueieie o ee?i?/i?e
iao?ieia??. Aeiia?oeiiao?eo (AI) o?aaea? ia?aaaaeii in?a iieiaeiai a?eo,
eiai ia?aa?a a?ae??ciy?oueny iaooeeueiei i?ia?anoaaiiyi c
?iaae?aeecaoe??th, ui aecia/a? iniaeeao aeooaeuei?noue ? nioe?aeueio
cia/ei?noue aea/aiiy eiai ao?ieia?? oa iaoiaaiaco. A inoaii? ?iee cia/ii
ci?ieeanue no?oeoo?a AI: a?aecia/a?oueny c??no aeiaaee?a o?ii?caoe??
aino?iai AI, a oaeiae, iacaaaeath/e ia ?ic?iaeo iiaeo iaoiae?a
e?eoaaiiy, ia? i?noea ca?eueoaiiy ieoiii? aaae AI o no?oeoo??
caoai?thaaiino? (Oa?a?aa E.A., 1992). Aaconi?oieie aeyaeythoueny ni?iae
a?aeaeaeeoe oa?i?ie ianoaiiy o?ii?/ii? ie?eiai? iaaeinoaoiino? (OII).
A?aeiii, ui iaeiei ?c oaeoi??a i?ia?anoaaiiy AI ? iino?eia iia?eueia
iaaeoiaeaeaiiy aioeaai?a o e?iaiia?a. Oiio a inoaii? ?iee ona /ano?oa
iianoa? i?iaeaia iiaeeeai? o/ano? a??onii? ?ioaeoe?? ye o ao?ieia??, oae
?, a?eueoith i??ith, o o?ii?caoe?? ? i?ia?anoaaii? AI. Aei i?yieo
aeieac?a o/ano? a??onii? ?ioaeoe?? a ao?ieia?? AI a?aeiineoueny
aeyaeaiiy ?o aioeaai?a o neeaae? ?ioiieo eiiieaen?a o iao?ia?iioaoao. ?
e iia?/i? aeieace. Oae, o oai?eo ia aino?ee ? o?ii?/iee AI cia/ii
cieaeaiee ai?no ?ioa?oa?iio ne?iaaoee e?ia? ? i?iaeoeoe?y ?ioa?oa?iio
eaeeioeeoaie. Oe?eeii a??ia?aeii, ui i?eai?/aiiy ?ioa?oa?iiooai?aiiy –
oe??? iaeaaaeeea?oi? eaiee i?ioea??oniiai caoenoo – iiaea ni?eyoe
ia?nenoaioe?? ??ciiiai?oieo a??on?a (?oaeaiei A.A., 1989).

O ca’yceo c oeei caaaeueia oaaaa iao?ieia?a caa?oa?oueny aei
oeeoiiaaaeia??onii? ?ioaeoe??, ui aeiaaino?ieiai ia?nenoo? a i?aai?ci?
ethaeeie oa aeyaey? nai? iaoiaaii? aeanoeaino? eeoa a oiiaao ia?aeiiiai
aai aoi?eiiiai ?ioiiaeao?oeeoo. Aca?iica’yceo OeIA ? aeiia?oeiiao?eoo
i?enay/ai? iiiaeeiie? ioae?eaoe?? (Muller GA, 1992, Park JS, 1994), oa e
oi aiie noinothoueny, aieiaiei /eiii, aeine?aeaeaiiy OeIA? o iaoe??io?a
ae?ae?cieo oeaio??a. Iecea i?aoeue i?enay/aia aeyaeaiith OeIA o oai?eo
ia ??ciiiai?oi? oi?ie AI ? ?icaeoeo OII (Gregory MC, 1988, Uj M, 1988,
Blanche P, 1996). Iieacaii, ui, a iniiaiiio, OeIA aeyaey?oueny a oai?eo
c IgA-iao?iiao??th: Muller GA ? ni?aaaoi?e, 1992, aeyaeyee a 90%
aeine?aeaeoaaieo iao?ia?iioao?a oai?eo ia IgA-iao?iiao?th aioeaai a??ono
oeeoiiaaae??. Oe? ?iaioe iinyoue iieniaee oa?aeoa?, aac ?icaeyaeo aieeao
aeaiiai a??ono ia ee?i?/i? i?iyae e ?ioi?oao oai?iai ia AI. Aea a?aeiii,
ui o oai?eo ?c cieaeaiith ?ioiiith ?aaeoeai?noth a ?acoeueoao?,
iai?eeeaae, ei?oeeinoa?i?aeii? oa?ai??, OeIA? iiaea ni?e/eieoe na?eici?
oneeaaeiaiiy, o oiio /ene? ca?eueoeoe aeenaaeain a ?ioii?e nenoai? ?
iia??oeoe noai oai?eo. I?e AI aeenaaeain a ?ioii?e nenoai? ? iaei??th c
eaiie iaoiaaiaoe/iiai eaioethaa, oiio noai?ththoueny oiiae aeey
aeoeaaoe?? oeeoiiaaae?? c eaoaioiei ia?aa?aii. O naith /a?ao, OeIA,
aeoea?coth/enue, aeeeeea? ae?aaeai? ci?ie a ?ioiiiio aiiainoac?,
iniaeeai a ee?oeii?e eaioe?, ui iiaea iaoyaeeoe ia?aa?a AI, oi?ioaaoe
no?ee?noue aei e?eoaaiiy, ?, ye iane?aeie, i?enei?eoe i?ia?anoaaiiy AI.
O iaoai?ci? ooeiaeaeoth/i? ae?? OeIA ia ie?ee aeae?eythoue aeae?eueea
iiiaio?a: i?yia oeeoiiaoe/ia ae?y, ooai?aiiy oee?eoethth/eo ?ioiieo
eiiieaen?a c ianooiiei a?aeeeaaeaiiyi ?o ia aacaeuei?e iaia?ai? eeoai/ea
ie?ee, a oaeiae noi?nia ae?y oeeo iaoai?ci?a, aea caaaeueii? aeoiee c
oeueiai ieoaiiy iaia (Ronco R, Verroust P, 1982). Oaeei /eiii, iiaeeeao
o/anoue OeIA? a iaoiaaiac?, o?ii?caoe??, i?ia?anoaaii? AI ? ?icaeoeo
?acenoaioiino? aei i?iaaaeaii? oa?ai?? inoaoi/ii ia c’yniaaii.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeine?aeaeaiiy
aeeiiaii o a?aeiia?aeiino? c ieaiii iaoeiai-aeine?aeieoeueeeo ?ia?o
Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ? ? o?aaiaioii IAe?
eaoaae?e i?iiaaeaaoeee aioo??oi?o oai?ia ? 2 “?ieue ?ioaeoe?eii?
eiioeaioe?? o aeieeiaii?, o?ii?caoe?? oa ia?aa?ao caiaeueieo
caoai?thaaiue ie?ie” (? aea?ae?a?no?aoe?? 01980002623).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa ?iaioe – aecia/aiiy ?ie?
oeeoiiaaaeia??ona a ?icaeoeo, i?ia?anoaaii?, a?eueo aaaeeiio ia?aa?ao
aeiia?oeiiao?eoo, iiaeeeaiai aieeao OeIA ia ee?ieei-?ioiieia?/i?
iieacieee oai?eo i?e ??ciiiai?oieo oi?iao aeiia?oeiiao?eoo, a oaeiae
?icaeoie no?eeino? aei i?iaaaeaii? oa?ai??.

Aeey ?aae?caoe?? oe??? iaoe iinoaaeai? ianooii? caaea/?:

1. Aea/eoe ?io?eiaai?noue OeIA oai?eo ia ??ciiiai?oi? oi?ie
aeiia?oeiiao?eoo.

2. Aecia/eoe a?oio oai?eo AI, iaea?eueoa noeeueio aei ?ioaeoe?? OeIA .

3. Aeine?aeeoe iniaeeaino? ee?i?/iiai ia?aa?ao aeiia?oeiiao?eoo o
?io?eiaaieo OeIA oai?eo.

4. Aea/eoe ci?ie ?ioiieia?/ieo iieaciee?a o ?io?eiaaieo OeIA oai?eo ia
aeiia?oeiiao?eo.

5. Aea/eoe iniaeeaino? ia?aa?ao aino?iai aeiia?oeiiao?eoo o ?io?eiaaieo
oai?eo ?c iaoith c’yniaoaaiiy iiaeeeai? o/ano? OeIA o o?ii?caoe?? aeaii?
oi?ie.

6. Iieacaoe iiaeeeao o/anoue OeIA o iaoiaaiac? aeiia?oeiiao?eoo oeyoii
aeine?aeaeaiiy iao?ia?iioao?a ca aeiiiiiaith iie?ia?acii? eaioethaiai?
?aaeoe?? c iaoith aeyaeaiiy AeIE oeeoiiaaaeia??ono.

Iaoeiaa iiaecia. Aea/aii iioe?ai?noue OeIA na?aae oai?eo ia aino?ee ?
??ciiiai?oi? oi?ie o?ii?/iiai aeiia?oeiiao?eoo.

Aeyaeaii noeeueio aei ?ioaeoe?? OeIA a?oio oai?eo ia o?ii?/iee
aeiia?oeiiao?eo – iao?ioe/io.

Iieacaii, ui a ?io?eiaaieo OeIA oai?eo ia?aa?a aino?iai aeiia?oeiiao?eoo
a?ae??ciy?oueny noeeuei?noth aei o?iiecaoe?? i?ioeano.

Anoaiiaeaii ?icoiaeaeaiiy a ee?i?/iiio ia?aa?ao aeiia?oeiiao?eoo a
?io?eiaaieo OeIA o ii??aiyii? c ia?io?eiaaieie. Iieacaii, ui a oe???
eaoaai??? oai?eo ia?aa?a aeiia?oeiiao?eoo oa?aeoa?eco?oueny a?eueoei
nooiaiai ae?aciino? ee?i?/ieo i?iya?a ? ?acenoaioi?noth aei i?iaaaeaii?
oa?ai??.

A?aecia/aii iniaeeaino? ci?i ?ioi?oaoo a ?io?eiaaieo oai?eo, ui
iieyaathoue o cieaeaii? ??aiy IgG, oeo?o eiiieaiaioo e cieaeaii?
a?aenioea oaaioeeooth/eo iaeo?io?e?a.

Iieacaii, ui ?ioi?iaoeaiei iaoiaeii aeine?aeaeaiiy OeIA? a i?aai?ci?
ethaeeie ? iie?ia?acia eaioethaiaa ?aaeoe?y aeey aeyaeaiiy AeIE OeIA o
a?ieia?/ieo na?aaeiaeuao ? iao?ia?iioaoao, i?ioa aeey aa??o?eaoe??
ae?aaiico OeIA? iaiao?aeiee ? ?OA, yeee aeiiiaith? ? aeicaiey? aeyaeoe
“?aii?” aioeo?ea aei OeIA o ne?iaaooe? e?ia?. Iieacaii iiaeeea?noue
o/ano? OeIA o ?icaeoeo aeiia?oeiiao?eoo, ui i?aeoaa?aeaeaii iayai?noth
AeIE OeIA o iao?ia?iioaoao.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Anoaiiaeaii aenieo /anoioo
?io?eiaaiino? oeeoiiaaaeia??onii oai?eo on?ia oi?iaie aeiia?oeiiao?eoo,
aaae/ee eiai ia?aa?a, ??ciini?yiiaai? ci?ie ?ioiii? nenoaie,
noeeuei?noue aei o?ii?caoe?? aino?iai AI ? ?acenoaioi?noue aei oa?ai?? a
?io?eiaaieo oai?eo, aeiaaaeaii ?ieue aeaiiai a??ono a iaoiaaiac?
aeiia?oeiiao?eoo. O ca’yceo c oeei iaa?oioiaaii iaiao?aei?noue
ianoaaeaiiy on?o oai?eo ia aeiia?oeiiao?eo ia iayai?noue
oeeoiiaaaeia??ono. Aeiaaaeaii iaea?eueoo ?ioi?iaoeai?noue iaoiaeo
anoaiiaeaiiy OeIA a i?aai?ci? ethaeeie oeyoii IE?. Ca aeiiiiiaith
oeueiai iaoiaeo iiaeia aecia/eoe aaciina?aaeiuei AeIE a??ono a
a?ieia?/ieo na?aaeiaeuao, ui na?ae/eoue i?i i?enooi?noue a??ono a
i?aai?ci?. Oaeiae aeinoaoiuei ?ioi?iaoeaiei ? iaoiae ?OA aeey aeyao
“?aii?o” aioeo?e (1-6 i?nyoe?a i?ney ?io?eoaaiiy). O aeiaaeeo iiceoeaieo
?acoeueoao?a aeine?aeaeaiiy ?aeiiaiaeiaaii i?ecia/aoe niaoeeo?/io
i?ioea??onio oa?ai?th, aei yei? a?aeiinyoueny no/ani? iaaee/i? i?aia?aoe
– aaioeeeeia??, oinea?iao, oa ?ioiiiiaeoethth/o oa?ai?th ca aeiiiiiaith
?cii??iaceio, eaaai?cieo, -o?iiceio, aai aeei?enoiaoth/e -?ioa?oa?ii.

?acoeueoaoe aeine?aeaeaiiy ai?iaaaeaeai? a ee?i?/io i?aeoeeo
iao?ieia?/iiai oa ioeueiiiieia?/iiai a?aeae?eaiue OIEE, a oaeiae
a?aeae?eaiue iia?o?yii-e?aiaeueieo oa eeoeiaeo ?ioaeoe?e OIE?E,
aoaeoeai?noue ai?iaaaeaeaiiy – iie?ioaiiy ae?aaiinoeee.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi i?iaiae?ciaaia iaoeiaa
e?oa?aoo?a ca ia?aiith oaiaoeeith, i?iaaaeaiee ?ioi?iaoe?eiee iiooe,
yeee aeicaieea aea?aoe iai?yi aeey aeine?aeaeaiue. Naiino?eii i?iaaaeaii
ianoaaeaiiy oai?eo ca?aeii c i?ia?aiith aeine?aeaeaiiy ia an?o eiai
aoaiao. Noaoenoe/ia ia?iaea ?acoeueoao?a aeine?aeaeaiue, iiaoaeiaa
iaoaiaoe/ieo iiaeaeae i?ioean?a caniaaie aa??aoe?eii? noaoenoeee, ui
?aae?co?oueny noaiaea?oieie iaeaoaie i?ia?ai noaoenoe/iiai aiae?co
STADIA 4.0 i STATISTICA FOR WINDOWS, aeeiiai? aaoi?ii iniaenoi.
Naiino?eii i?iaaaeaii aiae?c iaea?aeaieo aeaieo, noi?ioeueiaaii aeniiaee
oa i?aeoe/i? ?aeiiaiaeaoe??, ui aeo?eathoue c ?acoeueoao?a
aeine?aeaeaiiy.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??, ioae?eaoe??. Aeena?oaoe?y
ai?iaiaaii ia ni?eueiiio can?aeaii? eaoaae? i?iiaaeaaoeee aioo??oi?o
oai?ia ? 2 ? i?e?ia?ieia??, a??onieia?? oa ?ioiieia?? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iniiai? iieiaeaiiy oa ?acoeueoaoe aeena?oaoe?? aoee iaaiai?ai? ia
iaoeiai-i?aeoe/ieo eiioa?aioe?yo eaoaae?e IAO ? 2 OAeIO (1996-1998), IV
ui??/iiio Naieo-Iaoa?ao?cueeiio iao?ieia?/iiio nai?ia??
(Naieo-Iaoa?ao?a, 1996), ia can?aeaii? Oa?e?anueeiai iaoeiaiai
iaaee/iiai oiaa?enoaa (Oa?e?a, 1996), ia Ia?oiio i?aeia?iaeiiio
iaaee/iiio eiia?an? nooaeaio?a oa iieiaeeo a/aieo (Oa?iii?eue, 1997),
iaoeiai-i?aeoe/i?e eiioa?aioe?? “Ie?ee oa ?ioaeoe?y” (?aaii-O?aie?anuee,
1997), ia I?aeia?iaeiiio eiia?an? ?a?iiaenueei? iao?ieia?/ii?
anioe?aoe??, ?a?iiaenueei? anioe?aoe?? ae?ae?co oa o?ainieaioaoe??
(AEaiaaa, 1997), ia XIV c’?cae? oa?aiaao?a Oe?a?ie (Ee?a, 1998), ia
iaeani?e iao?ieia?/i?e eiioa?aioe?? “O?ii?/ia ie?eiaa iaaeinoaoi?noue”
(Oa?e?a, 1999).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?eii? ?iaioe iioae?eiaai? 5
noaoae o oeaio?aeueieo i?io?eueieo aeaeaiiyo, o oiio /ene? 2 o
i?ia?aeieo oaoiaeo aeo?iaeao, 3 noaoo? o ca??ieeao iaoeiaeo i?aoeue, 7
oac?a o ca??ieeao aeiiia?aeae, iaea?aeaii iiceoeaia ??oaiiy i?i aeaea/o
iaoaioo ia aeiao?ae.

Ianya oa no?oeoo?a aeena?oaoe??. Aeena?oaoe?th aeeeaaeaii ia 201
noi??ioe? iaoeiiieno ? aiia neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e,
o?ueio ?icae?e?a aeanieo niinoa?aaeaiue – iaoa??aee ? iaoiaee
aeine?aeaeaiiy, aeani? niinoa?aaeaiiy, iaaiai?aiiy ?acoeueoao?a,
caeeth/aiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e oa nieneo aeei?enoaii?
e?oa?aoo?e. ?iaioa ?ethno?iaaia 18 oaaeeoeyie, ui noaiiaeoue 10 noi??iie
? 58 iaethieaie (32 noi??iee). A?ae?ia?ao?/iee iieaciee i?noeoue 293
aeaea?aea, a oiio neeaae? – 184 ?iicaiieo aaoi??a (ui neeaaea? 35
noi??iie).

CI?NO ?IAIOE.

Ia’?eo, caniae ? iaoiaee aeine?aeaeaiiy. Ia’?eoii aeine?aeaeaiiy aoee
112 oai?eo (64 /ieia?ea oa 48 ae?iie o a?oe? 15-56 ?ie?a) ia
??ciiiai?oi? oi?ie AI, ui ia?aaoaaee ia e?eoaaii? o iao?ioe/iiio
a?aeae?eaii? Oa?e?anueei? iaeanii? ee?i?/ii? e?ea?i?. Na?aae ieo aoei 29
ia aino?ee oa 83 ia o?ii?/iee AI (iao?ioe/io oi?io ae?aaiinoiaaii o 40
oai?eo, eaoaioio-o 22, a?ia?oii?/io-o 11 ? ci?oaio-o 10 oai?eo).
Ae?aaiic AI anoaiiaethaaany ia i?aenoaa? caaaeueiiee?i?/ieo, a?io?i?/ieo
oa ?ino?oiaioaeueieo aeine?aeaeaiue. O eiiieaen a??onieia?/ieo
aeine?aeaeaiue aoiaeeee iaoiae oeeoieia?/ii? ae?aaiinoeee OeIA? o
inaaeao neeie oa na/?, iaoiae ?OA, aeyaeaiiy AeIE OeIA iaoiaeii
iie?ia?acii? eaioethaiai? ?aaeoe??. Iaoiae oeeoieia?/ii?
aeni?an-ae?aaiinoeee aeei?enoiaoaaany aeey aeyaeaiiy oeeoiiaaae?/ieo
ee?oei. Aeey anoaiiaeaiiy aioeo?e aei OeIA aeei?enoiaoaaany iaoiae ?OA
ca aeiiiiiaith ye?nii? oano-nenoaie aeey aeyaeaiiy ia?aeiii? OeIA.
I?eioeei iaoiaeo aaco?oueny ia aeyaeaii? “?aii?o” a??onniaoeeo?/ieo IgM,
ui ia?acothoueny i?e ?iciiiaeaii? a??ono o i?aai?ci?, ii/eiath/e c 1
aeiy i?ney ?io?eoaaiiy oa caa??aathoueny a e?ia? aei i?a?ieo. Oaeiae
aecia/aeenue “i?ci?” aioeo?ea, aai IgG, ye? ? aiaiianoe/ieie aioeo?eaie,
ui aeacothoue ia o?ii?/io eaoaioio ?ioaeoe?th. Aeey aecia/aiiy
oeeoiiaaaeia??onii? AeIE aeei?enoiaoaaany iaoiae iie?ia?acii?
eaioethaiai? ?aaeoe??. Nain iaoiaeo iieyaa? o aaaaoie?aoiiio eii?thaaii?
o?aaiaioo AeIE oa?iaioii AeIE-iie?ia?acith. Iiooe i?iaiaeeee
aaciina?aaeiuei o ee?i?/iiio iaoa??ae?–inaaeao na/? oa iao?ia?iioaoao.
Aei eiiieaeno aeine?aeaeaiue ?ioiiiai aiiainoaco oai?eo aoiaeeee iaoiaee
aeine?aeaeaiiy caaaeueiiai ?ioiiiai noaoono ? oa ?? ??ai?a (ee?oeiiee oa
aoii?aeueiee ?ioi?oao). Eiio?ieueia a?oia aeeth/aea 10 i?aeoe/ii
caei?iaeo in?a (5 ae?iie oa 5 /ieia?e?a) o a?oe? 20-38 ?ie?a aac
caoai?thaaiue ie?ie, c ii?iaeueieie iieacieeaie aeaieo
eaai?aoi?ii-?ino?oiaioaeueieo iaoiae?a aeine?aeaeaiiy. Iaea?aeai? aeai?
ii?aoeueiaai? noaoenoe/ii ia IAII ?AI ?N AO ca iaeaoii noaoenoe/ieo
i?ia?ai c aeei?enoaiiyi e?eoa??th Nouethaeaioa oa e?eoa??th caiaee
I??niia.

?acoeueoaoe oa ?o iaaiai?aiiy. I?e ianoaaeaii? oai?eo ia ??ciiiai?oi?
oi?ie AI iaie aeyaeaii aenieo /anoioo ?io?eoaaiiy OeIA. Oae, IgG
aecia/aeenue a 68% oai?eo. O 43% oai?eo aeyaeai? IgM. OeIE aecia/aeeny a
inaaeao na/? o 54% oai?eo, a inaaeao neeie – o 64% oai?eo. AeIE OeIA
aecia/aeanue a inaaeao na/? o 30% oai?eo. Oaeiae aeyaeaii AeIE OeIA o
3-o c 16-oe aeine?aeaeoaaieo iao?ia?iioao?a (19%). O a?oi? caei?iaeo
in?a o 1-ai aeyaeaii IgG, OeIE a inaaeao neeie, AeIE OeIA a inaaeao na/?
ia aecia/aeeny a aeiaeii? iniae c eiio?ieueii? a?oie. Oaea aeniea
?io?eiaai?noue oai?eo iiynith?oueny, i/aaeaeii, aeenaaeainii ?ioiii?
nenoaie. C ?ioiai aieo, a?aeiii, ui a iaoiaaiac? AI iniiaia cia/aiiy
iaaea?oueny ii?ooaiiyi a ?ioii?e nenoai?, iane?aeeii yeeo ? ??
iaaeinoaoi?noue ? nainea?e?caoe?y e?ioioeeo?a. Ana oea noai?th?
ni?eyoeeaee “a?oio” aeey ?io?eoaaiiy OeIA aai aeoeaaoe?? oeeoiiaaae?? c
eaoaioiei ia?aa?aii, ui naia ii nia? ca?eueoo? aeenaaeain a nenoai?
?ioi?oaoo (Diamod RD, 1989). O oai?eo ia aino?ee AI AeIE OeIA aeyaeaia a
inaaeao na/? 2-o ?c 14 oai?eo (14%), aioeo?ea (IgM) aeyaeai? a
ne?iaaooe? e?ia? 33% oai?eo, IgG – 53% oai?eo. O inaaeao na/? 47% oai?eo
ciaeaeai? OeIE. O a?eueoino? ?io?eiaaieo cia/ii a?eueoa ae?aaeaiee
iaa?yeiaee neiae?ii, aeuee ??aaiue i?ioa?io??? ? aaiaoo???. O
?io?eiaaieo oai?eo ii?yae c oeiiaeie aeey aino?iai AI ?ioiieie
ii?ooaiiyie a?aecia/aeeny a?eueo ae?aaeai? ?iceaaee ?ioiiiai aiiainoaco
a ii??aiyii? c ia?io?eiaaieie oai?eie ia aino?ee AI, ye? iieyaaee a
cieaeaii? caaaeueii? e?eueeino? O-eeioioeeo?a, cieaeaii? O-noi?ani??a,
cieaeaii? i?iaeoeoe?? IgA ? IgG, aeoeaiino? eiiieaiaioo ? ?ia?a?oe??
nenoaie oaaioeeoico (ca ?aooiie cieaeaiiy a?aenioea oaaioeeooth/eo
iaeo?io?e?a). Iaiaaath/enue aeaoe iiyniaiiy oeei ci?iai, ie aeoiaeeee c
oaeoo ?nioaaiiy ??ciiiai?oieo oi?i ca’yceo OeIA ?c aino?ei AI. Ii-ia?oa,
iiaeeeaa ao?ieia?/ia ?ieue OeIA o aeieeiaii? AI. Aaaaoi oaeo?a
(a?aenooi?noue ca’yceo c -aaiie?oe/iei no?aioieieii, ii/aoie i?ney A?A?,
oa?aeoa?i? ci?ie ?ioi?oaoo) na?ae/aoue ia ei?enoue ia?aeiiiai
ao?ieia?/iiai /eiieea OeIA. I?ioa, aeey i?aeoaa?aeaeaiiy oeueiai oaeoo
iaia? ia’?eoeaieo aeaieo, aei yeeo, ia iaoo aeoieo, a?aeiineoueny
aeyaeaiiy aioeaaio OeIA o neeaae? ?ioiieo eiiieaen?a aacaeueii?
iaia?aie.

I?i oa, ui OeIA, e??i caaaeaii? iiaeeeai? ao?ieia?/ii? ?ie?, oneeaaeith?
ia?aa?a aino?iai AI, na?ae/eoue oa, ui a ?io?eiaaieo oai?eo ia?aa?a
aino?iai AI oa?aeoa?eco?oueny, o ii??aiyii? c ia?io?eiaaieie, a?eueo
ae?aaeaieie i?ioa?io???th, aaiaoo???th, ci?iaie a ?ioii?e nenoai? oa
no?ee?noth aei i?iaaaeaii? oa?ai?? (oaaeeoey 1).

Oaae. 1. Iieacieee ?ioi?oaoo ?io?eiaaieo OeIA oai?eo ia AAI

?ioiieia?/i?

Iieacieee.Eiio?ieue 1 (E1) (caei?ia? iniae N=10)

Eiio?ieue 2 (E2) (oai?? AAI aac OeIA? N=10)?io?eiaai? oai?? ia AAI n=5

(ii??aiyiiy c iieacieeaie E2)

>E2

E2

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