I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE
AeA?AEAAIA I?AeI?E?INOAI “OE?A?INUeEEE IAOEIAI- AeINE?AeIEE ?INOEOOO
II?NUeEI? IAAeEOeEIE”
IIACOI Iaaei Aiaoie?eiae/
OAeE 616.37- 002-036.11
IAAeE*IA OA I?IOAN?EIA ?AAA?E?OAOe?ss I?AOe?AIEE?A II?NUeEIAI
O?AINII?OO, ssE? NO?AAEAeATHOUe IA O?II?*IEE IAIE?AAOEO
14.01.34.-aa?aoe?eia, eini?/ia oa ii?nueea iaaeeoeeia
Aaoi?aoa?ao ia caeiaoooy iaoeiaiai
nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
Iaeana- 1999
Aeena?oaoe??th ? ?oeiien
?iaioa aeeiiaia a Aea?aeaaiiio i?aei?e?inoa? “Oe?a?inueeee iaoeiai-
aeine?aeiee ?inoeooo ii?nueei? iaaeeoeeie ”, i. Iaeana
Iaoeiaee ea??aiee: Aeieoi? iaaee/ieo iaoe, aeioeaio
Caii?iae/aiei Ai?en Na?a?eiae/
aeioeaio eaoaae?e ii?nueei? iaaeeoeeie Iaeanueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo
Io?oe?ei? iiiiaioe aeieoi? iaaee/ieo iaoe,
Ie/eoaeei Ieoaeei THoeiiae/
ea??aiee a?aeae?eo eaia?ineii?/ii? o??o?a?? ? oieae?o?aco Ee?anueeiai
?inoeoooo ee?i?/ii? oa aenia?eiaioaeueii? o??o?a?? AII Oe?a?ie
aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee ni?a?ia?oiee
E?niaae Aieiaeeie? Ieaenaiae?iae/
noa?oee iaoeiaee ni?a?ia?oiee AeI “Oe?a?inueeee iaoeiai- aeine?aeiee
?inoeooo ii?nueei? iaaeeoeeie”
I?ia?aeia onoaiiaa Oa?e?anueeee ?inoeooo oaeineiiaeaiiy e?ea??a IIC
Oe?a?ie
Caoeno a?aeaoaeaoueny “_19_ “ eaioiy 1999 ?. i__13___aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.41.617.01 i?e Aea?aeaaiiio
i?aei?e?inoa? “Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ii?nueei?
iaaeeoeeie ” ca aae?anith: 270049, i.Iaeana, aoe. Noaeiiaoae?aia, 1.
C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Aea?aeaaiiai
i?aei?e?inoaa “Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ii?nueei?
iaaeeoeeie ”
Aaoi?aoa?ao ?ic?neaiee “16_”_aa?aciy_ 1999 ?.
A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,
ae.i.i., i?ioani? ?aiaoue?a I.I.
Aeooaeuei?noue i?iaeaie. I?iaeaia aeniei? caoai?thaaiino? ?
iniaeeainoae aeieeiaiiy oa e?eoaaiiy o?ii?/iiai iaie?aaoeoo (OI) iaaoaa?
a oiiaao ?iaioe ia ii?nueeiio o?ainii?o? aaaeeeaiai cia/aiiy. Cie?aia,
aeniea /anoioa caiaeaiiy i?aeoeoieiai? caeice (IC) aecia/a?oueny
niaoeeo?/ieie oiiaaie ?iaioe ii?ye?a, a?aceea?noth ia?aio?ie IC aei
no?aniaaiiiai aeeao [Eiaaiei A.A., 1995, 1997; Aieoaiei A.I., 1992;
Iaooaeuoaoei I.TH., 1992; Caii?iae/aiei A.N., 1998; Eaiaoueaa A.I.,
1998].
Iacaaaeath/e ia aeaye? oni?oe iaaeeeaiaioiciiai ? o??o?a?/iiai e?eoaaiiy
OI, inoaii?ie ?ieaie i?iaeaia ?ic?iaee aoaeoeaieo iaoiae?a e?eoaaiiy
oaeiai caoai?thaaiiy ? aeoaea aeaeaeith a?ae ?? ?ica’ycaiiy. Oea
iaoiiaeaii ye neeaaei?noth iaoiaaiaoe/ieo iaoai?ci?a ?icaeoeo OI,
iaaeinoaoiueith aoaeoeai?noth ?nioth/eo iaoiae?a e?eoaaiiy, oae ?
no??ieei c?inoaiiyi caoai?thaaiino? ia OI o oeea?e?ciaaieo e?a?iao, o
oiio /ene? e a Oe?a?i?. Ca aeaieie A.A.Oae?iiaa c? ni?aaao. (1998),
caoai?thaai?noue ia OI a Oe?a?i? ioe?ith?oueny o n?aaeiueiio
aaee/eiith, aeecueeith aei 1% a?ae on??? e?eueeino? ianaeaiiy, a
caoai?thaai?noue ia OI o ii?ye?a ? ua a?eueu aenieith – o 1,5- 2,5 ?aco
[E?niaae A.A., 1995].
E?eoaaiiy oai?eo ia OI ae??ciy?oueny neeaaei?noth, ? iaa?oue
canoinoaaiiy o??o?a?/ieo iaoiae?a ia iiaea aa?aiooaaoe iiaii?
eiiiainaoe?? o oai?eo oyaeeeo aieueiaeo a?ae/ooo?a ? caiia?aoe
ii?ooaiiyi c aieo oeoieiai- eeoeiaiai o?aeoo, oiaoi oae? oai?? caaaeaee
iio?aaothoue eiiieaeniiai e?eoaaiiy [Oae?iia A.A., 1997; Oka Y. et al.,
1993; Sameshima H. et al., 1993; Asseman C. et al., 1996; Norman J.G. et
al., 1996; Stephens F.O., 1997].
Iacaaeia?euei? ?acoeueoaoe uiaei e?eoaaiiy OI iiaeooue iiynithaaoenue ye
iaaeinoaoi?ie iiaeeeainoyie o??o?a?/ii? oaeoeee, ui canoiniao?oueny
nueiaiaei?, eiiieaenieie iaoiaeaie e?eoaaiiy, oae ? cia/iith i??ith
iane?aeeaie iaaeinoaoiueiai iaoiaaiaoe/iiai iaa?oiooaaiiy iaoiae?a
eiiieaeniiai e?eoaaiiy aeaiiai caoai?thaaiiy [Oae?iia A.A., 1997]. [Oka
Y. et al., 1993; Sameshima H. et al., 1993; Asseman C. et al., 1996;
Norman J.G. et al., 1996; Stephens F.O., 1997].
Ca aeaieie Caii?iae/aiea A.N. (1998), a oiiaao e?eoaaiiy OI aeoaea
aoaeoeaiei noiniaii caiia?aaiiy oneeaaeiaiiyi ?aiiueiai e a?aeaeaeaiiai
i?neyiia?aoe?eiiai ia??iae?a ? canoinoaaiiy eaca?iiai aei?ii?iaiiy
iecueei? ?ioaineaiino? ?io?a/a?aiiiai ae?aiaciio (EAI??Ae) ?
iaioieneo?e?io (IOO). I?e/iio ca oiia iaeii/aniiai aeei?enoaiiy
eiia?iaoe?? oeeo iaoiae?a a?aei?/a?oueny iioaioe?eiaaiee oa?aiaaoe/iee
aoaeo. Iaeiae o ?ac? oni?oiiai canoinoaaiiy oaeeo iaoiae?a o eiiieaeni?e
oa?ai?? aeeiai?ea ?aaa?e?oaoe?? oai?eo ? aeoaea iia?eueiith, cie?aia,
niinoa??aathoueny iniaeeaino? a?aeiinii ia?aeeniiai ieeneaiiy e?i?ae?a
(IIE). Iiaeia aaaaeaoe, ui aoaeoeai?noue canoinoaaiiy ?ic?iaeaiiai
eiiieaeno EAI??Ae +IOO ia? cia/i? ?aca?ae uiaei eiai iie?auaiiy,
iniaeeai yeui iiaa eaea i?i ei?aeoe?th o oai?eo i?ioean?a
a?eueii?aaeeeaeueiiai ieeneaiiy.
Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y
aeeiiaia a?aeiia?aeii aei ieaio iaoeiai-aeine?aeieo ?ia?o Aea?aeaaiiai
i?aei?e?inoaa “Oe?a?inueeee iaoeiai-aeine?aeiee ?inoeooo ii?nueei?
iaaeeoeeie” ? ? o?aaiaioii iaoeiai-aeine?aeii? oaie, ? aea?ae?a?no?aoe??
01.86.000.6102.
Iaoith ?iaioe aoea ?ic?iaea iaoiaaiaoe/ii iaa?oioiaaiiai eiiieaeniiai
e?eoaaiiy ii?ye?a, ui no?aaeaeathoue ia o?ii?/i? oi?ie iaie?aaoeoo, c
aeei?enoaiiyi o??o?a?/ieo, oa?iaeieia?/ieo ? o?c?ioa?aiaaoe/ieo
iaoiae?a, ei?eaoth/eo i?ioeane a?eueii?aaeeeaeueiiai ieeneaiiy oa
eieaaaiii?iaeoeoe??.
Iniiai? caaaeaiiy aeine?aeaeaiiy aoee oaeeie:
aea/eoe noai IIE o oai?eo – ?ia?oiee?a ii?nueeiai o?ainii?oo, yeeo aoei
i?iiia?iaaii c i?eaiaeo OI, e iniaeeaino? aeaieo iieaciee?a o ?ac?
canoinoaaiiy o eiiieaeni?e oa?ai?? EE, a oaeiae eiia?iiaaiiai
canoinoaaiiy EE ? eiiieaeno IOO+EAI??Ae;
?ic?iaeoe aenia?eiaioaeueio iiaeaeue OI ia iniia? aeine?aeaeaiue
aeeiai?ee aeoeaiino? o?eineio, ai?eace, e?iace, ?ia?a?oi?a o?eineio, a
oaeiae a?aeo?ii?aeace, eenei? oinoaoace; ae?aciino? i?ioean?a IIE ?
aioeieneaeaioiiai caoenoo; ??ai?a ienei?ie?io e ienee?ceio o ieaci?
e?ia?; a oaeiae aieueiai? /ooeeaino? ia ??cieo oa?i?iao, ii/eiath/e c
iiiaioo oi?ioaaiiy aenia?eiaioaeueiiai iaie?aaoeoo, ca aeiiiiiaith
caii?iaeoaaiiy e nenoaiiiai canoinoaaiiy no?aioicioioeeio;
aea/eoe aoaeoeai?noue ie?aiiai ? ii?aeiaiiai canoinoaaiiy e?ii?ai?
eeneioe (EE), IOO ? EAI??Ae o oaa?ei ?c aenia?eiaioaeueiei OI;
aea/eoe iniaeeaino? ?ioiieia?/ii? ?aaeoeaiino?, iieaciee?a
ooieoe?iiaeueiiai noaio IC ? IIE o oai?eo ia OI a oiiaao o?aaeeoe?eii?
oa?ai?? ? eiiieaenii? oa?ai?? c aeei?enoaiiyi IOO ? EAI??Ae;
aeine?aeeoe aeeiai?eo ??aiy (-ienei?ie?io, (-ienee?ceio, aeoeaiino?
a?aeo?ii?aeace ? (-aetheiceaeac o ieaci? e?ia? oai?eo, ye? i?aeeyaaee
eiiieaeniiio e?eoaaiith c oaaaeaiiyi EE ye ie?aii, oae ? a eiiieaen? c
IOO ? EAI??Ae;
aea/eoe aoaeoeai?noue eiiieaeniiai e?eoaaiiy oai?eo ia OI ca ?o noaiii o
a?aeaeaeaiiio i?neyiia?aoe?eiiio ia??iae? e iieacieeaie ?ioiieia?/ii?
?aaeoeaiino?, IIE, noeioeueiaaii? aene?aoi?ii? oa ?ie?aoi?ii? ooieoe?e
IC ca oiiae aeeth/aiiy aei eiiieaeno e?eoaaeueieo caoiae?a o??o?a?/ii?
ei?aeoe?? caoai?thaaiiy, oaaaeaiiy EE ye ie?aii, oae ? a eiiieaen? c IOO
? EAI??Ae;
aea/eoe iniaeeaino? i?ioan?eii? ?aaa?e?oaoe?? ii?ye?a i?ney eiiieaeniiai
e?eoaaiiy OI.
Iaoeiaa iiaecia. Aia?oa aecia/aii, ui aiane?aeie ?icaeoeo
aenia?eiaioaeueiiai OI, yeee ni?e/eiy?oueny caii?iaeoaaiiyi oeaieie IC
oei?aoeeii ia oii? canoinoaaiiy no?aioicioioeeio, niinoa??aa?oueny oaea:
i?aeaeuaiiy ??ai?a o?eineio, ai?eace, e?iace, c?inoaiiy aeoeaiino?
a?oeao?ii?aeace, eenei? oinoaoace, ??ai?a ienei?ie?io e ienee?ceio a
ieaci? e?ia?, ?ioaineo?eaoe?y IIE, cieaeaiiy aioeieneaeaioiiai caoenoo,
a oaeiae ?icaeoie i?aeaeuaii? aieueiai? /ooeeaino? oaa?ei i?ioyaii
ainueie oeaei?a a?ae iiiaioo caii?iaeoaaiiy IC. Aeiaaaeaii, ui EE
ni?e/eiy? aeica-caeaaeiee aoaeo uiaei cieaeaiiy oa?iaioai??, iieaciee?a
IIE, aioeieneaeaioii? oa?iaioaoeaii? aeoeaiino? a?aeo?ii?aeace, eenei?
oanoaoace, (-ienei?ie?io, (-ienee?ceio. Aeyaeaii iineeaiiy aeacaieo
aoaeo?a EE i?ae aieeaii ?o ii?aeiaiiai canoinoaaiiy c IOO ? EAI??Ae.
Aeiaaaeaii, ui aieueiaee neiae?ii, oa?aeoa?iee aeey i?iya?a OI,
i?aeeyaa? ?noioi?e ?aaeoeoe?? ia a?aeaeaeaieo no?ieao o oai?eo, yeei
i?iaiaeeee eiiieaenia e?eoaaiiy c aeeth/aiiyi EE, ? ? a?eueo ae?aciei
i?e oaaaeaii? aei e?eoaaeueiiai eiiieaeno IOO ? EAI??Ae. A oiiaao
eiiieaeniiai e?eoaaiiy, yea i?noeoue canoinoaaiiy EE, IOO ? EAI??Ae,
?noioii iie?auothoueny a?aeaeaeai? ?acoeueoaoe e?eoaaiiy oai?eo ia OI,
caa??aa?oueny ooieoe?iiaeueia caeaoi?noue aecie?eiii? /anoeie IC, yea
aecia/a?oueny o oanoao noeioeyoe?? nae?aoe?? ?c nae?aoeiii ?
iaie?aicei?iii, caa??aa?oueny ?ie?aoi?ia ooieoe?y, yea aecia/a?oueny ye
ca iieacieeii aacaeueii? ?ie?aoe?? ?inoe?io, oae ? aetheaaiio.
Canoinoaaiiy EE o eiiieaen? caoiae?a aeey e?eoaaiiy oai?eo ia OI
caaacia/o? ia a?aeaeaeaiiio ia??iae? a?eueo ae?acio ii?iae?caoe?th
iieaciee?a ?ioiieia?/ii? ?aaeoeaiino?, a oaeiae iieaciee?a IIE ?
oa?iaioaoeaii? eaiee aioeieneaeaioii? nenoaie. Aeiaaaeaii, ui
aeeoa?aioe?eiaaiee i?aeo?ae uiaei aeai?o iia?aoe?e ae?aioaaiiy ?
?acaeoe?? IC aeicaiey? aeinyaoe aeia?eo ?acoeueoao?a e?eoaaiiy o 84,7%
oai?eo ? caaeia?eueieo- o 11,9%. Canoinoaaiiy EE ?noioii ni?ey?
iie?auaiith ia?aa?ao iaeaeeae/iai i?neyiia?aoe?eiiai ia??iaeo ?
i?ioan?eii? ?aaa?e?oaoe?? oai?eo ia a?aeaeaeaieo oa?i?iao i?ney
iia?aoe??.
I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoao?a. Aeyaeaia aeniea
aoaeoeai?noue iaoiaaiaoe/ii iaa?oioiaaiiai eiiieaeniiai e?eoaaiiy ?
i?ioan?eii? ?aaa?e?oaoe?? ii?ye?a, ye? no?aaeaeathoue ia OI, aiane?aeie
aeeth/aiiy aei eiiieaeniiai e?eoaaiiy EE, yeo iaiao?aeii canoiniaoaaoe o
aeaeyae? aioo??oiueii’yciaeo oaaaeaiue ?c ?ic?aooieo 50 ia aea?/? ia
aeiao i?ioyaii 2 – 4-o oeaei?a. Ii?aeiaiiy EE ?c IOO, yeee oaiaeeoueny o
aeaeyae? aioo??oiueiaaiieo ?iooc?e ?c ?ic?aooieo 0,1 a ia 250 ie
?cioii?/iiai ?ic/eio iao??th oei?eaeo aei iia?aoeaiiai ao?o/aiiy ?
i?ioyaii 5-e aei?a i?ney iia?aoe??, ? ae?? EAI??Ae ia i?iaeoe?th IC aei
iia?aoe?? ? i?ioyaii o?ueio aei?a i?neyiia?aoe?eiiai ia??iaeo (aea?/? ia
aeaiue, o?eaae?noue naaino – 10 oa., aeiaaeeia oaee? – 0,89-0,95 iei)
ni?e/eiy? ae?acio iiceoeaio e?eoaaeueio ae?th. E??i oiai, cai?iiiiiaaia
iaoiaeeea e?eoaaiiy EE, IOO ? EAI??Ae iiaea canoiniaoaaoenue ye
naiino?eiee iaoiae oa?ai?? o oai?eo ia OI, ye? ia i?aeeyaathoue
o??o?a?/iiio e?eoaaiith.
?acoeueoaoe ?iaioe ai?iaaaeaeai? o ae?yeuei?noue o??o?a?/ieo
a?aeae?eaiue ?cia?euenueei? aanaeiiai?, ?ee?/?anueei?, Ieeiea?anueei?,
?ai?enueei?, E?e?enueei? ii?oiaeo e?ea?aiue.
Iniaenoee aianie aeena?oaioa. Aeena?oaio noi?ioethaaa iaoo, caaaeaiiy
aeine?aeaeaiiy, aeeiiaa aenia?eiaioaeuei? aeine?aeaeaiiy ? i?ia?a
eiiieaenia e?eoaaiiy oai?eo ia o?ii?/iee iaie?aaoeo, o oiio /ene? ?yae
o??o?a?/ieo ao?o/aiue ye iia?oth/ee o??o?a ? anenoaio, c?iaea aiae?c
io?eiaieo aeaieo ? noi?ioeuethaaa aeniiaee e i?aeoe/i? ?aeiiaiaeaoe??.
Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeine?aeaeaiue
aeieeaaeaii ia can?aeaii? Iaeanueeiai iaeaniiai iaoeiaiai oiaa?enoaa
o??o?a?a (1997), I- e i?aeia?iaei?e eiioa?aioe?? c ii?nueei? iaaeeoeeie
(Iaeana, 1997), Iaoeia?e eiioa?aioe??, i?enay/ai?e 80-??//th aeaae.
A.A.Oae?iiaa (Ee?a, 1998), noi?nieo can?aeaiiyo eaoaae? ii?nueei?
iaaeeoeeie, ii?iaeueii? ? iaoieia?/ii? o?c?ieia?? IAeIO (Iaeana, 1997,
1998, 1999).
Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 6 ?ia?o, ?c yeeo
5 – aeo?iaeuei? noaoo?.
No?oeoo?a e ianya aeena?oaoe??. Ci?no ?iaioe aeeeaaeaii ia 193 noi??ieao
iaoeiiieniiai oaenoo. Aeena?oaoe?y neeaaea?oueny c? anooio ? oanoe aeaa:
iaeyae e?oa?aoo?e – 1 aeaaa; iaoa??ae ? iaoiaee – 1 aeaaa; iniaeno?
aeine?aeaeaiiy – 3 aeaae; aeniiaee, i?aeoe/i? ?aeiiaiaeaoe??, iieaae/ee
e?oa?aoo?e. Oaeno ?ethno?iaaiee (?enoie?a – 17, oaaeeoeue – 21).
A?ae?ia?ao?y i?noeoue 122 aeaea?aea, iaae?oeiaaieo ee?eeeoeath, ? 134 –
?io? aeaea?aea.
CI?NO ?IAIOE
Iaoa??aee oa caniae aeine?aeaeaiiy. Aenia?eiaioaeuei? aeine?aeaeaiiy.
Niinoa?aaeaiiy n?oaaaeeeecy ca yiia o?oi?/iiai aecna?eiaioo ia 275
a?eeo uo?ao-caioeyo e?i?? A?coa? iacoth a?ae 180 aeo 320 a. O oaa?ei
ni?e/eiyee iiaeaeue OI oeyoii ioieiaeaeaiiy oeaieie IC oei?aoeeii o
ii?aeiaii? c oaaaeaiiyi no?aioicioioeeio [Oeeii?eiaa O.Ae., 1995]. Ca
eiio?ieue aoei acyoi iani?aaaeiueiiia?iaaieo uo??a.
?ioiieia?/i? iaoiaee aeine?aeaeaiiy Aeey aecia/aiiy ooieoe?oiaeueioao
coaio O-cecoaie e?ioooeeo?a aea/aee cnaoeeo?/i? ee?oeii? ?aaeoe??
a?na?/ooeeaino? in vitro. Cie?aia, c oe??th iaoith aea/aee ?aaeoe?th
aaeueioaaiiy i?eeeiaiiy ee?oei (?AIE), ?aaeoe?th aeanoo?ainoi?iaoe??
e?ioioeeo?a (?AOE), ?aaeoe?th cnaoeeo?/iiao ?ocaoeoooai?aiiy (A-?OE,
I-?OE), a oaeiae ?aaeoe?th aaeueioaaiiy i?a?aoe?? e?ioioeeo?a (?AIE)
[Aoaa?a??oe I.A. c? ni?aaao., 1990; 1991]. ?ioioaeoaoe?ie eeac?a A, M ?
G aecia/aeeny o?iiaoia?ao?/iei iaooaeoi [Iao?ia ?.A., 1991].
Oa?aeoa?enoeea oa?iaioaoeaieo ? iaoaaie?/ieo ci?i. sse niaoeeo?/iee
iieaciee aeieeiaiiy ? ?icaeoeo iaie?aaoeoo o ieaci? e?ia? aecia/aee
aeoeai?noue o?eineio ca A?eaiaa?ii – Oaoa?ieeii; ?ia?a?oi?a o?eineio –
ca Oaaa?aaeii o iiaeeo?eaoe?? Oaoa?ieeiaa; aeueoa-ai?eace – ca iaoiaeii
Ea?aaay. Aeine?aeaeaiiy ai?noo caaaeueiiai oieanoa?eio i?iaaaeeee ca
iaoiaeii ?eueea; oieanoa?eio, e?iii?ioa?ae?a aeniei? aonoeie – ca
iaoiaeii Aaaey i?ney aaia?ei-ia?aaioeaai? i?aoeei?oaoe?? ? inaaeaeoaaiiy
ne?iaaoee aiii?ioa?i-aaoaai?nieo e?iii?ioa?ae?a; o?eae?oea?eaee oa
caaaeuei? e?i?aee – ca aeiiiiiaith ae?aaiinoe/ieo iaai??a o??ie “Eaoaia”
(*ao?y); a oaeiae cae?enithaaee aeaeo?io?aoe/iee ?iciiae?e
e?iii?ioa?ae?a o aae? aaa?ice [Ci?uee?ia A.A. c? ni?aaao., 1997].
Aeoeai?noue a?aeo?ii?aeace aecia/aee ca noaiaea?oiei iaoiaeii [Aca?aiie
E.N., Aaia?aeia E.E., 1994], b- ienei?ie?io ? b- ienee?ceio – ca
i?ia?ae?eiiaei iaoiaeii [Anao?ai? A.N., 1956], aeoeai?noue b-
aetheiceaeac – ca iaoiaeeeith Borooach K. et al., (1961), aeoeai?noue
eenei? oinoaoace – ca noaiaea?oiei iaoiaeii [Aca?aiie E.N., Aaia?aeia
E.E., 1994].
Aecia/aiiy ??aiy iaeiiiaiai ae?aeueaeaa?aeo (IAeA) i?iaaaeeee ca
aeiiiiiaith o?iaa?a?oo?iai? eeneioe [E.Ae.Noaeueiay, O.A.Aa?eoaeee,
1977]. O ieaci? e?ia? ? a a?eo?ioeeoao aecia/aee aeoeai?noue
aeooao?iiia??ieneaeace (AOI), aeooao?ii?aaeoeoace (A?), eaoaeace, a
oaeiae noia?ieneaeaeeniooace (NIAe) a a?eo?ioeeoao [Ooaaeiaa A.I.,
Aioiiiaa O.A., 1997]. Ca eiio?ieue a?aee a?aeiia?aei? iieacieee
i?aeoe/ii caei?iaeo in?a aiaeia?/iiai a?eo.
Ee?i?/i? niinoa?aaeaiiy ? eiiieaenia oa?ai?y. O o??o?a?/iiio
a?aeae?eaii? *i?iiii?nueei? oeaio?aeueii? aanaeiiai? ee?i?/ii? e?ea?i?
ia aiaeiiio o?ainii?o? ca ia??iae c 1987 ii 1998 ??. c i?eaiaeo OI
i?iaaaeaia e?eoaaiiy 127 oai?eo- i?aoe?aiee?a ii?nueeiai o?ainii?oo, a
oiio /ene? 83 ae?iie oa 44 /ieia?e?a, ?ao?iniaeoeaiee aiae?c
aaciina?aaei?o oa a?aeaeaeaieo ?acoeueoao?a o??o?a?/iiai ?
eiina?aaoeaiiai e?eoaaiiy yeeo noaiiaeoue iniiao aeaiiai aeine?aeaeaiiy.
Na?aaei?e a?e oai?eo noaiiaea 43,7(5,1 ?ie?a.
Ae?aaiinoeea cae?enithaaeany ia i?aenoaa? eiiieaeniiai ianoaaeaiiy
oai?eo c aeei?enoaiiyi iaoiae?a oeueo?acaoeiaiai, ?aioaaiieiii’thoa?iiai
aeine?aeaeaiue, eaia?ineii??, iaoiaeo aeenoaioe?eii? ?aae?aoe?eii?
ae?aaiinoe/ii? oaieiiao???, aia?ia?ao?? IC, aiaeineii?/ii? ?ao?ia?aaeii?
oieaia?ia?ao??, a oaeiae ee?i?ei- eaai?aoi?ieo aeaieo.
Oaaaeaiiy EE (o?ieoiaa eeneioa, ASTA Medica AG, I?ia//eia) cae?enithaaee
aeicaie a?ae 10 aei 50 ia/ea, a/i, aea?/? ia aeiao. Aeey eaca?ioa?ai??
aeei?enoiaoaaany eaca?iee aia?ao ia a?nai?ae? aae?th “Oci?” c aeo?aeiith
iiooaei?noth 3 Ao ?iioeueniiai ?aaeeio ae?? (300 Aoe), aaia?oth/ee oaee?
aeiaaeeiith 0,89 – 0,95 iei; o?eaae?noue naaino noaiiaeea 10 oa. IOO
(“o?aioae”, Oaano) canoiniaoaaee uiaeiaiai aioo??oiueiaaiii ii 0,1 a ia
250 ie ?cioii?/iiai ?ic/eio Na CL.
Noaoecoe/ia oa?iaea ?acyeueoao?a aeine?aeaeaiue i?iaaaeeeanue ?c
canoinoaaiiyi caaaeueiii?eeiyoeo o iaaeeeo-a?oeoa?/ieo aeine?aeaeaiiyo
na?aiao?e/ieo ? iana?aiao?e/ieo iaooae?a coaoecoe/ioao aiae?co
[Nanaoeeaa Ae., 1968; Ayaea? A.A., Aaieei A.A., 1973; ss.Ay?ao e ae?.,
1991] ia eoin’thoa?? IBM PC/AT ca aeiiiiiaith n?oa?ai coaoecoe/ioao
aiae?co.
1. Aenia?eiaioaeueia iaa?oiooaaiiy eiiieaeniiai iaoiaeo e?eoaaiiy OI.
Aeey iiaeaethaaiiy OI aoea aeei?enoaia iaoiaeeea eiia?iiaaii? ae??
no?aioicioioeeiii, o?iiiei aei ia?aio?ie IC, ?c caii?iaeoaaiiyi oeaieie
IC [Oeeii?eiaa O.Ae., 1996].
*a?ac 24 aiae. i?ney caii?iaeoaaiiy oeaieie IC o uo??a niinoa??aaeinue
c?inoaiiy aeoeaiino? o?eineio a e?ia? o 8,6 ?aco ii??aiyii c eiio?ieai
(P0,05).
I?ae aieeaii 7-aeaiieo oaaaeaiue IOO (20,0 ia/ea) o oaa?ei ia 8-io
oeaei? iieacieee aeoeaiino? o?eineio a 3,2 ?aco, ai?eace ? e?iace a 2,8
? 2,3 ?aco ia?aaeuoaaee oae? o eiio?ie? (P0,05), aeoeai?noue ?ia?a?oi?a o?eineio aoea iaioith, i?ae o eiio?ie?,
ia 16% (P>0,05). I?ae aieeaii EAI??Ae (10- oa.), IOO (20,0 ia/ea) ia
oii? i?ny/iiai oaaaeaiiy EE (10,0 ia/ea) on? aeine?aeaeoaai? iieacieee
ia a?ae??ciyeenue a?ae oaeeo o a?oi? iani?aaaeiueiiia?iaaieo oaa?ei
(P>0,05).
O uo??a ?c OI /a?ac 8 oeaei?a ??ai? IAeA o ieaci? ? a a?eo?ioeeoao aoee
aeueie a?ae eiio?ieueieo cia/aiue a?aeiia?aeii o 3,17 ? 4,62 ?aco
(P0,05). A oiiaao ii?aeiaiiai
canoinoaaiiy IOO (20,0 ia/ea) ? EAI??Ae (10-oa.) ??ai? IAeA o ieaci? ? a
a?eo?ioeeoao ia?aaeuoaaee a?aeiia?aei? iieacieee o eiio?ie? a 2,4 ? 3,0
?ace (P0,05).
EE (10,0 ia/ea) a oiiaao OI (8-e oeaeaeaiue) cieaeoaaea ??aaiue b-
ienei?ie?io, b- ienee?ceio, aeoeai?noue a?aeo?ii?aeace ? eenei?
oinoaoace o ii??aiyii? c eiio?ieai a?aeiia?aeii ia 70 ? 60% (P0,05).
A oiiaao aieeao IOO (20,0 ia/ea), EAI??Ae (10-oa.) ia oii? i?ny/iiai
canoinoaaiiy EE (10,0 ia/ea) a?aei?/aeany i?aeoe/ii iiaia ii?iae?caoe?y
c aieo an?o aeine?aeaeoaaieo iieaciee?a (P>0,05).
I?ae aieeaii EE aeicith 10,0 ia/ea ?ioaineai?noue aieueiaeo ?aaeoe?e,
ye? aeieeaee o uo??a o a?aeiia?aeue ia cauaieaiiy oainoa, ia?aaeuoaaea
oaeo o eiio?ie? ia 80% (P0,05).
Oaeei /eiii, iaaaaeai? ?acoeueoaoe na?ae/aoue i?i oa, ui EE iineeth?
oa?aiaaoe/io ae?th IOO, EAI??Ae noiniaii oa?iaioaoeaieo ii?ooaiue, a
oaeiae aieueiai? /ooeeaino? o uo??a ?c OI.
2. Aaciina?aaei? ?acoeueoaoe ??ciiiai?oieo iaoiae?a o??o?a?/iiai ?
eiiieaeniiai e?eoaaiiy oai?eo ia OI
Ianoaaeaii 127 oai?eo – ii?ye?a ?c ??cieie oi?iaie OI a?eii a?ae 25 aei
53 ?ie?a, ye? iaee noaae ieaaaiiy ia noaeiao a?ae 2 aei 25 ?ie?a. ?c ieo
69 iaoe??io?a io?eiaee eiiieaenia o??o?a?/ia e?eoaaiiy, ?ioei aoei
i?iaaaeaia eiiieaenia eiina?aaoeaia e?eoaaiiy c canoinoaaiiyi EE o
ii?aeiaii? ?c IOO ? EAI??Ae. Eiio?ieueio a?oio neeaaeaee 32 oai?eo, yeei
i?iaiaeeany eo?n o?aaeeoe?eiiai e?eoaaiiy.
O 12 oai?eo aoei cae?eniaia aioo??oi? ae?aioaaiiy aeno?aia?aio?iaoicieo
e?no IC, yea aeeiioaaee oeyoii oi?ioaaiiy oe?ieiai a?/ea e?noe c oiieith
eeoeith ia a?aeeeth/ai?e iaoe? ca iaoiaeii ?o aai aeiaa?e iaoe? ca
A?aoiii ? “caaeooeith” i?ea?aeii? iaoe? ca A.A.Oae?iiaei, noi?iiaaiiai o
ieaeiueiio iiethn? e?noe. Oeenoiaano?inoii?th ? oeenoiaeoiaeaiinoii?th
cae?eniaii a?aeiia?aeii o 14 e 13 oai?eo. O?nooei?thiinoii?y ia
ao?a/aiiio ae?aiaae? c a?aeeeth/aiith ca ?o iaoeath oiiei? eeoee aoea
aeeiiaia o 2 oai?eo. Iicaeiaaeith iaie?aaoi?thiinoii?th i?iaaaeaii o 17
oai?eo.
?c 58 oai?eo, yeei aoee aeeiiai? iia?aoe?? aioo??oiueiai ae?aioaaiiy,
i?neyiia?aoe?ei? oneeaaeiaiiy niinoa??aaeenue o 5 in?a. ?c ieo iiia?ee
aeaa iaoe??ioe: iaeei – i?ney oeenoiaano?inoii?? ? iaeei – i?ney
o?nooei?thiinoii??.
I?ieneiaeueia ?acaeoe?y IC (IAe?) ca Wippl-A.A.Oae?iiaei o
pilorus-caa??aath/iio aa??aio? aoea aeeiiaia o 3 oai?eo. Aeenoaeueia
?acaeoe?y IC cae?eniaia o 8 oai?eo.
I?ney IAe? ? aeenoaeueii? ?acaeoe?? IC i?neyiia?aoe?ei? oneeaaeiaiiy
?icaeaaeenue o aeaio oai?eo: a iaeiiio aeiaaeeo niinoa??aaeinue
aeieeiaiiy e?ainoi?iiiueiai i?aeae?ao?aaiaeueiiai aanoeano, a o ae?oaiai
oai?iai i?ney aeenoaeueii? ?acaeoe?? IC ?icaeioany ia?eoii?o, yeee
cae?i/eany eaoaeueiei e?ioeai. Oaeei /eiii, eaoaeuei?noue o oe?eiio
noaiiaeea 4,3%.
O ieaci? e?ia? oai?eo ia OI aei iia?aoe?? iaei i?noea c?inoaiiy
eiioeaio?aoe?? iaeiiiaiai ae?aeueaeaa?aeo (IAeA; ia 70%) ? ae??iiaeo
eii’thaao?a (AeE; o 2,.2 ?aco). E??i oiai, o ieaci? e?ia? oaeiae
cieaeoaaany ai?no ye caaaeueiiai aeooao?iio, oae ? eiai a?aeiiaeaii?
oi?ie (a?aeiia?aeii ia 40 ? 26,6%), aioeieneaeaoieo oa?iaio?a: NIAe (ia
37%), aeooao?iiia?ieneaeace (o 1,8 ?aco) ? aeooao?ii?aaeoeoace (ia 36%)
(P0.05). Aecia/aaeiny i?aeaeuaiiy (ia 25%)
eiioeaio?aoe?? caaaeueiiai aeooao?iio, a oaeiae (ia 31%) aeoeaiino? NIAe
(P0,05),
aeoeai?noue aeooao?iiia?ieneaeace – ia 4,6% ? aeooao?ii?aaeoeoace – ia
5,5% (P>0,05). Canoinoaaiiy a?oai?io A o eiiieaen? c IOO ? EAI??Ae ia
i?eaiaeeei aei c?inoaiiy e?eoaaeueiiai aoaeoo, yeee a?aei?/aany i?e
ii?aeiaiiio canoinoaaii? IOO ? EAI??Ae.
Ca oiiae canoinoaaiiy IOO aeicith 0,1 a a?aei?/aeiny cieaeaiiy ai?noo
(-ienei?ie?io: eiai ??aaiue noaiiaea 10,7±0.9 ieiieue/e, a aeicith 0,2 a
– aei 7.9 ± 0.8 ieiieue/e, ui oaeiae aoei aeinoia??ii iaioei, i?ae o
eiio?ie? (P0,05), oei/anii /an ye a?eueo o?eaaea ae?y (30 oa.)
ni?e/eiyea ciaioaiiy ai?noo ai?iieeneioe aei 9,0±0,7 ieiieue/e (P0,05). I?ae
aieeaii e?ii?ai? eeneioe aeicith 50,0 ia ??aaiue ienei?ie?io ciaiooaaany
aei 9,3±1,0 ieiieue/e, a ienee?ceio – aei 10,0±1,1 ieiieue/e (P0.05). Canoinoaaiiy EAI??Ae (10-
oa. naaine) ? IOO (0,1 a) ia ci?ithaaei ??aiy aeoeaiino?
N-aoeaoee-(-aetheicai?i?aeace, yeee noaiiaea 4,7±1,0 oi.i./ie (P>0,05).
Ii?aeiaia canoinoaaiiy e?ii?ai? eeneioe (25 ia), IOO (0,1 a) ? EAI??Ae
(10 – oa. naaine) i?ecaiaeeei aei cieaeaiiy ??aiy aeoeaiino?
N-aoeaoee-(-aetheicai?i?aeace, ui noaiiaea 1,8±0,7 oi.i./ie ? aoa
aeinoia??ii iaioei o ii??aiyii? c oaeei o oai?eo ia OI aac e?eoaaeueieo
ae?e (P
0,05), ?ia?a?oi?a o?eineio – caeeoaeanue a?eueo iecueeith, i?ae o
eiio?ie? (ia 13,9%) (?0,05). O ?ac? e?eoaaiiy ?c canoinoaaiiyi EE aeine?aeaeoaai? iieacieee
ia a?ae??ciyeenue a?ae eiio?ieueieo cia/aiue (Oaae. 2).
Oaaeeoey 2
Ci?ie oa?iaioaoeaii? aeoeaiino? ieacie e?ia? o oai?eo ia OI a oiiaao
eiiieaeniiai e?eoaaiiy
Eiio?ieue (i?aeoe/ii caei?ia?)
(n=16)
OI
(n=12) OI+ eiiieaenia
o?aaeeoe?eia
e?eoaaiiy
(n=15) OI+e?ii?aa eeneioa+ IOO+EAI??Ae
(n=27)
O?einei
(iiieue/n.e.) 26,9(4,3
41,6( 5,6* 38,7( 5,2 30,0( 4,2
?ia?a?oi? o?eineio
(ieiieue/n.e.) 10,2( 0,3
7,2(0,3*** 8,9( 0,3** 9,7( 0,4
Ai?eaca
(a//.e.) 869,2( 73,2 1330,5( 123,6** 1278,4( 113,4** 965,5( 72,6
E?iaca
(ieiieue/n.e.) 565,3( 62,8 792,6( 81,7* 650,2( 73,4 550,3( 54,5
I?ei?oea: *-P0,05), a oaeiae aeinoia??ia o ii??aiyii? c ??aiai aei ii/aoeo
eiiieaeniiai e?eoaaiiy i?aeaeuaiiy aeoeaiino? eaoaeace (ia 15%),
oea?oeiieaci?io (ia 25%) ? NIAe ( ia 14%). I?ae aieeaii eiiieaeniiai
e?eoaaiiy oai?eo c oaaaeaiiyi eiiieaeno IOO+EAI??Ae a?aei?/aeinue
?noioia cieaeaiiy ??aiy oieanoa?eio- ia 37% o ii??aiyii? c eiai ??aiai
aei ii/aoeo e?eoaaiiy (PI?AEOE*I? ?AEIIAIAeAOe??
C iaoith iaea?eo aoaeoeaiiai i?iaaaeaiiy eiiieaeniiai e?eoaaiiy ii?ye?a,
ye? no?aaeaeathoue ia OI, iaiao?aeii aei eiiieaeno e?eoaaeueieo caoiae?a
aeeth/eoe EE, yeo ne?ae canoiniaoaaoe o aeaeyae? aeaio- /ioe?eoeaeiaaiai
eo?no aioo??oiueii’yciaeo ?i’?eoe?e ?c ?ic?aooieo ii 50 ia aea?/? ia
aeiao.
Ca oiiae canoinoaaiiy EE ca aeacaiith noaiith c?inoa? oa?aiaaoe/ia
aoaeoeai?noue canoinoaaiiy eiiieaeno IOO+EAI??Ae (a?aeiia?aeii ii 0,1 a
i?ioyaii 5 aei. aioo??oiueiaaiii ? o?eaeiaiaa ii?ii?iaiiy i?iaeoe?? IC
aea?/? ia aeaiue ii 10 oa. ca aeiiiiiaith aia?aoa "Oci?" c aeo?aeiith
iiooaei?noth 3 Ao, 300 Aoe, aeiaaeeiith oaee? 0,89- 0,95 iei). Aeaiee
iaoiae iiaea aooe canoiniaaiei a oiiaao ii?nueeiai ?aeno.
NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??
Aeei?enoaiiy iaioieneo?e?io aeey e?eoaaiiy aenia?eiaioaeueiiai
iaie?aiiae?ico//AEo?iae Aeaaeai?? Iaaee/ieo iaoe.- 1998.- O.4,?3.- N.
530- 538 (a ni?aaao. c Eiaaieii A.I., Caii?iae/aieii A.N., Oaiae?ith
I.A., Aiaeeaanueeei E.N.).
Oa/aiea iineaiia?aoeeiiiiai ia?eiaea o aieueiuo o?iie/aneei iaie?aaoeoii
a oneiaeyo i?eiaiaiey iaioieneoeeeeia e eio?ae?aniiai eaca?iiai
eceo/aiey ieceie eioaineaiinoe//A?niee ii?nueei? iaaeeoeeie.- 1998.-
?2.- N. 25-27.
?ae iiaeaeaeoaei/iie aeaeacu: aiciiaeiinoe ?aaeeeaeueiiai ea/aiey a
ioaeaeaiee iauaoe?o?ae/aneiai i?ioeey//Aiiaeu oe?o?ae/aneie
aaiaoieiaee.- 1998.- O.3,?3.- N.222- 223 (a niaao. n Caii?iae/aiei A.N.,
Oeoeia(i A.E., Ai?aoiia(i A.A., Ai?iaeaaa(i E.A.).
Canoinoaaiiy aioeieneaeaio?a o i?aoe?aiee?a ii?nueeiai o?ainii?oo,
iia?iaaieo c i?eaiaeo o?ii?/iiai iaie?aaoeoo//A?niee ii?nueei?
iaaeeoeeie.- 1999.- ?1.- N. 33.
Aeei?enoaiiy e?ii?ai? eeneioe (EE) oa iaioieneo?e?io (IOO) a
i?neyiia?aoe?eiiio ia??iae? o i?aoe?aiee?a ii?nueeiai o?ainii?oo, oai?eo
ia o?ii?/iee iaie?aaoeo (OI)//A?niee ii?nueei? iaaeeoeeie.- 1999.- ?1.-
N. (a ni?aaao. c Caii?iae/aieii A.N.)
Oe?o?ae/aneay oaeoeea i?e iaie?aiiae?ica//A na. iao/iuo ?aaio "II-e
Eiia?an o??o?a?a Oe?a?ie".- Ee?a- Aeiiaoeuee, Aeae. "Ee?i?/ia
o??o?a?y".- 1998.- N.112- 113 (a niaao. n Caii?iae/aiei A.N., Oeoeia(i
A.E., Iaoiaiei A.A., Ai?aoiia(i A.A., Ieuaiei A.A.).
AIIOAOe??
Iiacoi I.A. Iaaeeoeeineay e i?ioanneiiaeueiay ?aaaeeeoaoeey ?aaioieeia
ii?neiai o?ainii?oa, eioi?ua no?aaeatho o?iie/aneei iaie?aaoeoii.-
?oeiienue.
Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.34- aaeaoeeiiiay, einie/aneay e ii?neay
iaaeeoeeia.- Ainoaea?noaaiiia i?aaei?eyoea "Oe?aeineee iao/ii-
enneaaeiaaoaeueneee einoeooo ii?neie iaaeeoeeiu".
Enneaaeiaaiea iinayuaii i?iaeaia iaoiaaiaoe/aneiai iainiiaaiey
iiaeoiaeia e eiiieaeniiio ea/aieth OI o ?aaioieeia ii?neiai o?ainii?oa.
A oneiaeyo o?iie/aneiai yenia?eiaioa iieacaii oi?ie?iaaiea o?iie/aneiai
yieeaioiaaiaca i?e ni/aoaiiii i?eiaiaiee caii?aaeeaaiey oeaie aeaeacu e
aaaaeaiee no?aioicioioeeia, ieacuaathuaai oiene/aneee yooaeo a ioiioaiee
oeaie IAE. A aeaiiuo oneiaeyo ia ainueiie iaaeaea n iiiaioa aicaeaenoaee
o aeeaioiuo ioia/aeenue i?iyaeaiey, oa?aeoa?iua aeey OI: aunieay
aeoeaiinoue o?eineia, aieeacu, eeiacu, ieceee o?iaaiue eiaeaeoi?a
o?eineia, iiauoaiea eioaineaiinoe ia?aeeniuo i?ioeannia, aunieay aieaaay
/oanoaeoaeueiinoue. A oneiaeyo aeaiiie iiaeaee auei iieacaii, /oi EE e
IOO ieacuaatho aeica- caeaeneiia oa?aaiaaoe/aneia aeaenoaea, a EEIEEAe
i?e n?aaeiae aeeeoaeueiinoe naaina (30 iei) oaeaea aucuaaao nieaeaiea
oa?iaioaiee. Ni/aoaiea EE n eiiieaenii IOO+ EEIEEAe nii?iaiaeaeaaony
iieiie eiiiainaoeeae iaoieiae/aneeo i?iyaeaiee. Iioaioee?iaaiea
oa?aiaaoe/aneeo yooaeoia iiae aeeyieai EE ioia/aeinue oaeaea a ioiioaiee
iiauoaiiuo a nayce n OI iieacaoaeae ia?aeeniiai ieeneaiey eeieaeia,
b-ienei?ieeia e b-ieneeeceia, aeaeo?iieaeacu, eeneie oinoaoacu, a oaeaea
aieaaiai neiae?iia. A ?aaioa i?aaenoaaeaiu ?acoeueoaou ianeaaeiaaii 127
aieueiuo - ii?yeia no?aaeathueo OI, ec eioi?uo 69 iaoeeaioia iieo/eee
eiiieaeniia oe?o?ae/aneia ea/aiea, inoaeueiui auei i?iaaaeaii
eiiieaeniia eiina?aaoeaiia ea/aiea n i?eiaiaieai EE a ni/aoaiee n IOO e
EEIEEAe. Eiio?ieueioth a?oiio ninoaaeee 32 aieueiuo, iieo/eaoeo eo?n
o?aaeeoeeiiiiai ea/aiey. I?eiaiaiea EE, IOO e EEIEEAe i?eaiaeeei e
nieaeaieth o?iaiy IAeA e AeE a n?aaiaiee n niioaaonoaothueie
iieacaoaeyie aei ia/aea ea/aiey. Auei ioia/aii oaeaea oaaee/aiea
eiioeaio?aoeee iauaai aeooaoeiia e aai o?aeoeee, aeoeaiinoe NIAe,
iieacaoaeae aeooaoeiiia?ieneaeacu e aeooaoeii?aaeoeoacu. Aeeth/aiea a
eiiieaen aeoaieia A (100 ia/nooee) ia nii?iaiaeaeaeinue oneeaieai
oa?aiaaoe/aneiai aeaenoaey eiiieaena IOO+ EEIEEAe. Iiae aeeyieai EE (25
ia), IOO - 0,1 a e 10- iei naainia EEIEEAe iaaethaeaeinue au?aaeaiiia
nieaeaiea o?iaiy (-ienei?ieeia e (-ieneeeceia. E?iia yoiai, iiae
aeeyieai ?ac?aaioaiiiai ea/aaiiai eiiieaena iaaethaeaeanue ii?iaeecaoeey
aeoeaiinoe aeaeo?iieaeacu, N-aoeaoee-(-aetheicaieieaeacu. A oneiaeyo
i?eiaiaiey ?ac?aaioaiiiai iaoiaea ea/aiey OI oi?ioee ?acoeueoao
iaaethaeaeny o 50 aieueiuo (84,7%), oaeiaeaoai?eoaeueiue –o 7 (11,9%) e
iaoaeiaeaoai?eoaeueiue – o 2 aieueiuo (3,4%). A oneiaeyo i?eiaiaiey
aeaiiiai eiiieaena a ioaeaeaiiii ia?eiaea ioia/aeanue au?aaeaiiay
ii?iaeecaoeey iieacaoaeae eiioiieiae/aneie ?aaeoeaiinoe (O- e A-
eeioioeeoa?iie nenoaiu), iieacaoaeae noeioee?iaaiiie nae?aoeee
(nae?aoei, iaie?aiceiei), o?iaiy iaie?aaoe/aneeo oa?iaioia a e?iae
iaoeeaioia, a oaeaea iieacaoaeae IIE.
Oaeei ia?acii, eiiieaeniay ioeaiee ?acoeueoaoia i?eiaiaiey EE iieacuaaao
aa aunieoth yooaeoeaiinoue o aieueiuo OI- ?aaioieeia aiaeiiai
o?ainii?oa.
Eeth/aaua neiaa: o?iie/aneee iaie?aaoeo, ii?neie o?ainii?o, eeiiaaay
eeneioa, iaioieneoeeeei, eio?ae?aniia eaca?iia eceo/aiea ieceie
eioaineaiinoe.
Iiacoi I.A. Iaaee/ia oa i?ioan?eia ?aaa?e?oaoe?y i?aoe?aiee?a ii?nueeiai
o?ainii?oo, ye? no?aaeaeathoue ia o?ii?/iee iaie?aaoeo.- ?oeiien.
Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.34- aa?aoe?eia, eini?/ia oa ii?nueea
iaaeeoeeia.- Aea?aeaaia i?aei?e?inoai "Oe?a?inueeee iaoeiai- aeine?aeiee
?inoeooo ii?nueei? iaaeeoeeie".
Caaaeaiiyi aeine?aeaeaiiy aoeia aecia/aiiy aoaeoeaiino? canoinoaaiiy
e?ii?ai? eeneioe o eiiieaeniiio e?eoaaii? ii?yeua- oai?eo ia OI. Ca oiia
aenia?eiaioo ia iiaeae? OI o uo??a, ui a?aeoai?thaaeanue oeyoii
caii?iaeaiiy oeaieie caeice ia oii? canoinoaaiiy no?aioicioioeeio
aeiaaaeaii iie?auaiiy ia?aa?ao caoai?thaaiiy ye iuae aieeaii
naiino?eiiai canoinoaaiiy EE, oae ? i?e ?? eiiieaeniiio aeei?enoaii? c
IOO oa E?I??Ae. O ii?ye?a- oai?eo ia OI, ye? io?eiaee o??o?a?/ia
e?eoaaiiy (69 in?a), oa eiiieaenia eiina?aaoeaia e?eoaaiiy (57 in?a)
anoaiiaeaii a?eueoo aoaeoeai?noue o canoinoaaiiy ?ic?iaeaiiai
e?eoaaeueiiai eiiieaeno o a?aeiioaii? aei ii?iae?caoe?? iieaciee?a IIE,
oa?iaioaoeaii? aeoeaiino? e?ia? (o?einei, ai?eaca, e?iaca, ?ia?a?oi?
o?eineio), a?aeo?ii?aeaca, aetheiceaeace, ??aiy ienei?ie?io oa
ienee?ceio. I?inoaaeai? o a?aeaeaeaiiio ia??iae? (a?ae 5 i?nyoe?a aei 5
?ie?a) ?acoeueoaoe cana?ae/eee oaeiae ae?acio oa?aiaaoe/io
aoaeoeai?noue- ca?aeii iieaciee?a oa?iaioaoeaii? aeoeaiino? e?ia?,
?ioiieia?/ii? ?aaeoeaiino?.
Eeth/ia? neiaa: o?ii?/iee iaie?aaoeo, ii?nueeee o?ainii?o, e?ii?aa
eeneioa, iaioieneo?e?i, ?io?a/a?aiia eaca?ia aei?ii?ithaaiiy iecueei?
?ioaineaiino?.
Povzun P.A. Medical and professional rehabilitation of sailors who
suffer from chronic pancreatitis.- Manuscript.
Thesis for a candidate's degree by speciality 14.01.34- air- fly, marine
and space medicine.- Governmental structure "Ukrainian Research
Institute of Marine Medicine".
The efficacy of lipoic acid in complex treatment of sailors suffered
from cnronic pancreatitis was determined. Under condition of
experimental modeling of chronic pancreatitis in rats via frozening of
pancreatic tissue with the preliminar administration of streptozotocin
the improvement of the pathological disease development both in case of
lipoic acid and it’s coadminsitration with pentoxyphillin and infrared
laser irradiation of low intenisty was shown. In sailors who were
treated surgically (69 patients) and those who were not operated on (57
patients) the more pronounced efficacy of worked complex method of
treatment was shown with regard to processes of peroxidation, enzymatic
activity of blood (tripsin, amylasem lipase, inhibitor of tripsin),
hyaluronidase, glucosidase, level of oxyproline and oxylisine. During
the postponed period (from 5 months up to 5 years) the pronounced
therapeutic efficacy was evident with regard to enzymatic activity of
blood abd immunological activity.
Key words: chronic pancreatit, marine transport, lipoic acid,
pentoxyphillin, infrared laser irradiation of low intensity.
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