Застосування літію карбонату в комплексному лікуванні хворих на гострі гепатити А і В: Автореф. дис… канд. мед. наук / І.Г. Грижак, Київ. НДІ епідем

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Ee?anueeee iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa

?ioaeoe?eieo oai?ia ?iai? E. A. A?iiaoaanueeiai

OAeE 616.36 — 002 — 059 + 546.34 + 612.017.1 + 612.112.3 + 575

A?EAEAE ?AI? AIAOIAE*

CANOINOAAIIss E?O?TH EA?AIIAOO A EIIIEAENIIIO

E?EOAAII? OAI?EO IA AINO?? AAIAOEOE A ? A

14.01.13 — ?ioaeoe?ei? oai?iae

Aaoi?aoa?ao ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?aaii-O?aie?anuee?e aea?aeaai?e iaaee/i?e aeaaeai??
IIC Oe?a?ie.

IAOEIAEE EA??AIEE:

aeieoi? iaaee/ieo iaoe, i?ioani? Aeeeee Aiaaeai Ieeieaeiae/, caa?aeoaa/
eaoaae?e ?ioaeoe?eieo oai?ia ?aaii- O?aie?anueei? aea?aeaaii? iaaee/ii?
aeaaeai??.

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? Ee?e/aiei Aeieo?i Oaaei?iae/,
caa?aeoaa/ eaoaae?e ?ioaeoe?eieo oai?ia A?iieoeueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i. I.?. Ie?iaiaa;

aeieoi? iaaee/ieo iaoe Oaa/aiei Eaii?ae TH??eiae/, caa?aeoaa/ eaoaae?e
?ioaeoe?eieo oai?ia Euea?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo
?i. Aeaieea Aaeeoeueeiai.

I?IA?AeIA ONOAIIAA:

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 23 aa?aniy 1999 ?ieo i 1100
aiae

ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae. 26.614.01 i?e
Ee?anueeiio iaoeiai-aeine?aeiiio ?inoeooo? ai?aeai?ieia?? oa
?ioaeoe?eieo oai?ia ?iai? E.A. A?iiaoaanueeiai IIC Oe?a?ie ca
aae?anith: 252015, i. Ee?a — 15, aoe. N?/iaaiai iianoaiiy, 23.

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? Ee?anueeiai
iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i.
E.A. A?iiaoaanueeiai.

Aaoi?aoa?ao ?ic?neaiee “ 21 ” na?iiy 1999?.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee, aeieoi? iaaee/ieo iaoe
Aiae A.Ae.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. A Oe?a?i? i?iaeiaaeo? ?a?no?oaaoeny aenieee
??aaiue caoai?thaaiino? ia aaiaoeoe A ? A, caeeoa?oueny cia/iith
na?aaeiy o?eaae?noue iaeiiai aeiaaeeo oai?iae, cono??/a?oueny
oaeeaiiae?aiee ia?aa?a, ?aoeeaeeae oa o?ii?caoe?y i?ioeano o 10-15%
oai?eo ia aaiaoeo A ?, iacaaaeath/e ia no/ani? iaoiaee ?ioaineaii?
oa?ai??, i?aeoe/ii iiia?aaeiueith caeeoa?oueny nia?oi?noue a?ae
ia/?ieiai? aioeaoaeiiao?? oa ?ioeo oneeaaeiaiue (0,12 — 1,1%), — ana
oea coiiaeth? iino?eiee ?ioa?an iaoeiaoe?a aei aeaii? i?iaeaie ( Aiae
A.Ae., 1990; Aa?anoi A.A., 1993; Iinoiaeo A.A. e niaao., 1995;
Aiae?ae/ei I.A., 1996; Aiceaiiaa AE.E., 1997).

Aecia/aeueiei /eiieeii o iaoiaaiac? iani?eyoeeaeo oi?i caoai?thaaiiy
aai eiai oneeaaeiaiue ? noai ?ioiii? ?aaeoeaiino? i?aai?cio:
ee?oeiiiai ? aoii?aeueiiai ?ioiiiai noaoono, oaaioeeoa?ii? aeoeaiino?
iae?ioaa?a ? iaeo?io?eueieo a?aioeioeeo?a, nenoaie ?ioa?oa?iio,
eiiieaiaioo oiui. A?aoiaoth/e neacaia, a oaeiae iaaeinoaoith
aoaeoeai?noue ao?io?iiii? oa?ai??, ? iaa?oioiaaieie ni?iae aeei?enoaoe
i?aia?aoe c ?ioiiiiaeoethth/eie aeanoeainoyie a eiiieaeniiio e?eoaaii?
oai?eo ia a??oni? aaiaoeoe. Ieoaiith canoinoaaiiy ?ioiio?iiieo cania?a o
ee?i?/i?e i?aeoeoe? a??onieo aaiaoeo?a ca inoaii?e /an i?eae?eeee oaaao
aaaaoi aeine?aeiee?a: O?ieia A.O. e niaao., 1990; Gregorio G.V.,
1994; Aeeeee A.I., 1995; Aiae?ae/ei I.A. ? ni?aaao, 1995, 1996 oiui.
Canoiniaoaaeeny ianooii? i?aia?aoe: eaaai?cie, o?iae?i, nieai?i, iao??th
ioeea?iao, i?iae?a?icai, eo?aioee, ?cii?eiacei, ?ioa?oa?ii oa eiai
?iaeoeoi?e, a a ?ac? caa?ice ia/?ieiai? aioeaoaeiiao?? —
aetheiei?oeeinoa?i?aee ? aioee?ioioeeoa?iee ?ioiiaeiaoe?i. Eiaeai ?c
iacaaieo i?aia?ao?a iii?e iiceoeaiee aoaeo ia ia? anaioiiethth/i? ae??
ia ?ioiio nenoaio ? ia caaaeaee aa?aioo? iioei?caoe?th i?ioean?a
?ioiiiaoiaaiaco a??onieo aaiaoeo?a, oiio ca inoaii?e /an
niinoa??aa?oueny oaiaeaioe?y aei canoinoaaiiy iioeiaeueieo eiia?iaoe?e
?ioiiiiaeoeyoi??a, aeeth/ath/e e aioa?ini?aaioe, aioeieneaeaioe, ui
iiaea aeaoe noiiaaiee /e iioaioe?eiaaiee aoaeo (Aic?aiiaa AE.?., 1990,
1997; Iinothe A.?. ? ni?aaao.,1991; Aa?ieoeueea E.A., 1991; Aeeeee A.I.,
1995; Ainiiaea?nueeee ?.ss., 1997). Oaeee iaoiae ? aeinooiiei ?
aoaeoeaiei, aea i?eaiaeeoue aei iie?i?aaiac??, iaeii/anii noath/e
aei?iae/ei.

O a?o/eciyi?e oa caei?aeiii?e e?oa?aoo?? ? iia?aeiieaiiy i?i /eneaii?
iaoeia? aeine?aeaeaiy, ye? ?ice?eaathoue aaaaoia?aii? ?ioiio?iii?
aeanoeaino? eii?a e?o?th ( Aenaiaiei A.?. e niaao.,
1983; Iaiieeia A.A., 1988; ssai?eianueeee E.E. e niaao., 1984; Fernandes
L.F., Fox R.A., 1980; Skotnicki A.B., 1985; Wu Y.Y. 1992).
A?aecia/a?oueny, ui eiie e?o?th ci?iththoue ooieoe?th ?ioiieiiiaoaioieo
ee?oei a iniiaiiio /a?ac ianooii? iaoai?cie: aeieaaeo aaeai?eaooeeeeace
? ciaioaiiy ni?aa?aeiioaiiy oeAIO / oeAIO, i?eai?/aiiy oinoie?iace A2 ?
ciaioaiiy ooai?aiiy i?inoaaeaiaeei?a, i?eai?/aiiy Na+/ Ca2+
o?ainiaia?aiiiai iai?io. Ci?ie aioo??oiueiee?oeiiiai aiiainoaco,
aeeeeeai? eiiaie e?o?th, i?eaiaeyoue aei ca?eueoaiiy aeoeaiino? aaea
iiia?aaeiuei aeoeaiaaieo e?ioioeeo?a, iineeaiiy ?aaeoe?e
?icaoeiooai?aiiy, aeanoo?ainoi?iaoe??, i?ie?oa?aoe??, c?inoa? e?ea?ia
aeoeai?noue e?ioioeeo?a; ca?eueoo?oueny ioe iaeo?io?eueieo a?aioeioeeo?a
oa oaaioeeoa?ia aeoeai?noue iaeo?io?e?a. Aoaeoe eii?a e?o?th
iiina?aaeeiaothoueny /a?ac aieea aeayeeo e?ioie?i?a ( ?E-2, ENO, OII
), iie?auaiiy i?ioean?a ee?oeiiiai iaoaaie?cio, noaa?e?caoe?th ee?oeiieo
oa e?ciniiaeueieo iaia?ai, aioeieneaeaioi? aeanoeaino? (Ioeoa?yi A.A.
e niaao., 1983, 1985). E?o?th ea?aiiao ?c aenieith aoaeoeai?noth
canoiniaoaaany o oai?eo ?c yo?iaaiieie iaeo?iiai?yie i?e o?i?ioa?ai??
eaeeic?a /e ceiye?nieo iiaiooai??a, i?e i?iiaiaaeo o?aaeaiiyo, o oai?eo
ia anoiaoe/iee a?iio?o, aaneoe?o, ?ioaeoe?eii- aea?a?/iee a?o?eo, NI?Ae
oiui ( Skotnicki A.B. et al. 1985; Iaeueiee A.A., Iaeueiee A.E.,
1988). Iia?aeiieaiiy i?i canoinoaaiiy e?o?th ea?aiiaoo a eiiieaeni?e
oa?ai?? oai?eo ia a??oni? aaiaoeoe a e?oa?aoo?? ia cono??/athoueny.

O e?eoaaeuei?e i?aeoeoe? aaaaea?oueny, ui na?aaeiueioa?aiaaoe/ia
eiioeaio?aoe?y eiio a ne?iaaooe? e?ia? 0,6-1,5 iiieue/e, i?e i?e
iaaaoeaiiai aieeao ia ia?aio?iaoici? i?aaie, a oiio /ene? ? ia/?ieo, ia
iienaii. Iaeiae, ?ioiiiiaeoethth/? aoaeoe e?o?th iiaeooue niinoa??aaoeny
i?e cia/ii iaio?e eioeaio?aoe?? eiio, i?ae oa, yea aeinyaa?oueny o
ineo?ao?e/i?e i?aeoeoe? ( Shopsin B. et al. 1971). I?aia?ao e?o?th
ea?aiiao ye i?inoa iai?aai?/ia niieoea o ia/?ioe? ia iaoaaie?co?oueny, a
oiio ia iio?aao? iai?oaeaiiy oa?iaioaoeaieo nenoai aaiaoioeeo?a, ui ?
aaaeeeai a oiiaao iaoieia?? ia/?iee. A?eueoa oiai, i?ae aieeaii e?o?th
a?aeaoaa?oueny iaeiie/aiiy ae?eiaaio a ia/?ieiaeo ee?oeiao /a?ac eiai
?inoe?iiiiae?aio ae?th ? i?eai?/aiiy aetheiiaiaaiaco ( Eaueineee E.A. e
niaao., 1982; Ethaeiia A.E.,1984; Ceieoeueeee A.I. 1986; Rodrigues —
Gil J.E., et al., 1993 ).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa aeeiiaia
a ?aieao iniiaiiai iaoeiaiai iai?yieo ?aaii-O?aie?anueei? iaaee/ii?
aeaaeai??: “ ?ic?iaea iiaeo iaaee/ieo oaoiieia?e oa noaiaea?o?a yeino?
ae?aaiinoeee, i?io?eaeoeee oa e?eoaaiiy iaeaaaeeea?oeo caoai?thaaiue” ?
? o?aaiaioii ni?eueii? eiiieaenii? iaoeiai-aeine?aeii? ?iaioe eaoaae?
?ioaeoe?eieo oai?ia ? oaeoeueoaonueei? o??o?a?? ia oaio: “ ?ic?iaea
iiaeo iaoiae?a ?aiiuei? aeeoa?aioe?aeueii? ae?aaiinoeee a??oniiai
aaiaoeoo ? iaoai?/ii? aeiaoyieoe? oa ae?aaiinoeee ?aeo
iaie?aaoia?e?a?ii? ciie. Aecia/aiiy e?eoa???a ooieoe?iiaeueii?
iaaeinoaoiino? ia/?iee c iaoith iiia?aaeaeaiiy oneeaaeiaiue a
i?neyiia?aoe?eiiio ia??iae? ? ?ic?iaea iaoiaeee eiiieaeniiai
o??o?a?/iiai e?eoaaiiy ? ?aaa?e?oaoe?? oai?eo c iaoai?/iith
aeiaoyieoeath” ? 01.03.037.96 i.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa ?iaioe — aea/eoe aoaeoeai?noue
e?o?th ea?aiiaoo ye i?aia?aoa ii?iioei?/ii? oa ?ioiio?iiii? ae?? a
eiiieaeniiio e?eoaaii? oai?eo ia aino?? aaiaoeoe A ? A c ??cieie
oi?iaie aaaeeino?.

Iniiai? caaea/? aeine?aeaeaiiy:

1. Aeine?aeeoe a aeeiai?oe? noai ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo
i?aai?cio, oaaioeeoa?ii? aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a o
oai?eo ia aino?? aaiaoeoe A ? A, ye? io?eioaaee e?o?th ea?aiiao.

2. Anoaiiaeoe ia iniia? aeacaieo oano?a iiaeeea?noue iioei?coaaoe
?ioiio a?aeiia?aeue a oiiaao ?ioaeoe?eiiai i?ioeano a oai?eo ia aaiaoeoe
A ? A c ??cieie oi?iaie aaaeeino?, aeeth/ath/e oeo, ye? io?eioaaee
i?aaei?cieii.

3. Aea/eoe ooieoe?iiaeueiee noai aaiioeio niiaoe/ieo ee?oei i?aai?cio
o oai?eo ia a??oni? aaiaoeoe oa aieea e?o?th ea?aiiaoo ia oeeoiaaiaoe/i?
iieacieee.

4. ?ic?iaeoe ? cai?iiiioaaoe aeey i?aeoe/ii? ioi?iie caei?ia’y
iioeiaeuei? aa??aioe noai ?ioiio?iiii? oa?ai?? ?c canoinoaaiiyi e?o?th
ea?aiiaoo o oai?eo ia aino?? aaiaoeoe A ? A.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa canoiniaaii e?o?th
ea?aiiao ye i?aia?ao ii?iioei?/ii? oa ?ioiio?iiii? ae?? a eiiieaeniiio
e?eoaaii? aino?eo aaiaoeo?a A ? A, iaa?oioiaaia aeioe?euei?noue eiai
i?ecia/aiiy.

Aia?oa aeey ioe?iee nooiaiy aeoeaiino? oeeoioiene/ieo e?ioioeeo?a
aeei?enoaii ?ioaa?aeuei? ?ioiieia?/i? eiao?oe??ioe — ?ioiiiai oeeoie?co
oa i?e?iaeiuei? oeeoioiene/iino? ( E?Oe ? EIOe ).

Aeyaeaii, ui e?eoaaiiy oai?eo ia aaiaoeo A c aeei?enoaiiyi e?o?th
ea?aiiaoo i?eaiaeeoue aei ca?eueoaiiy iiioeyoe?? aaeeeeo a?aioey?ieo
e?ioioeeo?a, ciaioaiiy ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a oa
iineeaiiy oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a.

Iieacaii, ui e?o?th ea?aiiao o oai?eo ia aaiaoeo A ciaioo? aeeaeio
?ioiiaeai?an?? oa ?ioiii? aaoiaa?an??, iiceoeaii aieeaath/e ia O-
e?ioioeeoe, aaeee? a?aioey?i? e?ioioeeoe, oee?eoethth/? ?ioii?
eiiieaene. O oai?eo ia aaaeeo oi?io aaiaoeoo A ?c ia?aaea?nieeaie
aioeaoaeiiao??, ye? io?eioaaee i?aaei?cieii, aeinyaa?oueny
?ioii?aaa?e?oaoe?y.

Anoaiiaeaii iiceoeaiee aieea e?o?th ea?aiiaoo ia iieacieee oaaioeeoa?ii?
aeoeaiino? iaeo?io?e?a ? ciaioaiiy /anoioe aaeoa??aeueieo oneeaaeiaiue
o oai?eo ia aaiaoeo A.

O oai?eo ia aino?? aaiaoeoe A ? A anoaiiaeaii caeiiii??i? ii?ooaiiy
ooieoe?iiaeueiiai noaio aaiioeio (ONA) niiaoe/ieo ee?oei, ye?
ia?aaoaathoue a ?ioa?oac?, oiio iieaciee ONA iiaeia aeei?enoiaoaaoe ye
aeiaeaoeiaee e?eoa??e a ioe?ioe? aoaeoeaiino? e?eoaaiiy. I?ae aieeaii
e?o?th ea?aiiaoo a?aeaoaa?oueny iie?auaiiy oeeoiaaiaoe/ieo iieaciee?a.

O i?aenoieo, iiceoeai? aoaeoe e?eoaaiiy c e?o??i ea?aiiaoii
i?iyaeythoueny a iie?auaii? ee?i?ei-a?io?i?/ieo iieaciee?a o iaoe??io?a
?c na?aaeiueiaaaeeith oi?iith aaiaoeoo A oa o oai?eo ?c
ia?aaea?nieeaie aioeaoaeiiao??, ye? io?eioaaee i?aaei?cieii. O oai?eo ia
aaiaoeoe A ? A anoaiiaeaii ciaioaiiy i?iya?a aaaaoinoaeeiii? aeenoii??.

?ic?iaeaia ? ai?iaiaaia noaia eiiieaenii? oa?ai?? ?c canoinoaaiiyi
e?o?th ea?aiiaoo aeey e?eoaaiiy oai?eo ia aino?? aaiaoeoe A ? A c
??cieie oi?iaie aaaeeino?, cie?aia aeey oai?eo ia aaaeeo oi?io aaiaoeoo
A ?c ia?aaea?nieeaie aioeaoaeiiao??, ye? io?eioaaee i?aaei?cieii.

I?aeoe/ia cia/aiiy ?iaioe. Cai?iiiiiaaiee eiiieaen iaoiae?a
aeine?aeaeaiiy aeicaiey? aeyaeoe ? ioe?ieoe c?ooaiiy o aaaeeeaeo
?ioiiiaoiaaiaoe/ieo eaieao aino?iai aaiaoeoo A ? A, ui ni?ey? oi/i?oiio
i?iaiicoaaiith ia?aa?ao oai?iae, i?aeai?o aaeaeaaoii? oa?ai?? oa
eiio?ieth ca ?? aoaeoeai?noth. Aeaiee eiiieaen ?ioiieia?/ieo
aeine?aeaeaiue ? aeinooiiei c iaeyaeo ia i?inoioo oaoi?/iiai aeeiiaiiy
oa aeiiii?/io aeioe?euei?noue ? iiaea aeei?enoiaoaaoenue o iianyeaeaii?e
e?eoaaeuei?e i?aeoeoe?.

Oni?oia canoinoaaiiy e?o?th ea?aiiaoo a eiiieaeniiio e?eoaaii? oai?eo ia
aaiaoeoe A ? A ?c ??ciith oi?iith aaaeeino? aeicaiey? aeei?enoiaoaaoe
eiai c iaoith iioei?caoe?? ?ioiieia?/ieo ?aaeoe?e a oiae? ?ioaeoe?eiiai
i?ioeano, iineeaiiy oaaioeeoa?ii? aeoeaiino? iaeo?io?eueieo
a?aioeioeeo?a ? iiia?aaeaeaiiy aaeoa??aeueieo oneeaaeiaiue, onoiaiiy
i?iya?a aaaaoinoaeeiii? aeenoii??, a a ?acoeueoao? — aeinyaaoe
oaeaeoiai ee?i?/iiai iaeoaeaiiy, e?aui? iaaee/ii? ?aaa?e?oaoe?? oai?eo.

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeai? a e?eoaaeueiee i?ioean
aaiaoieia?/iiai a?aeae?eaiiy i?nueei? ee?i?/ii? ?ioaeoe?eii? e?ea?i?
i. ?aaii-O?aie?anueea.

Iniaenoee aianie caeiaoaa/a. Iniaenoa o/anoue iieyaaea o i?iaaaeaii?
aiae?oe/iiai iaeyaeo e?oa?aoo?ieo aeaea?ae, naiino?eiiio aeeiiaii?
ee?i?ei-?ioiieia?/ieo aeine?aeaeaiiue. Io?eiai? aeai? caeiaoaa/
noaoenoe/ii ii?aoethaaa oa ?ioa?i?aooaaa, noi?ioethaaa aeniiaee oa
i?aeoe/i? ?aeiiaiaeaoe??, iine?aeiaii ai?iaaaeea ?o o ee?i?/io
i?aeoeeo. Aecia/aiiy eiioeaio?aoe?? e?o?th a ne?iaaooe? e?ia? i?ia?a o
i?iaeaii?e eaai?aoi??? a?io?i?/ii? aeieia?? ?OAeIA i?ae ea??aieoeoaii
caa. eaai?aoi???th i?io. ?. A. Iacaie, a oeeoiaaiaoe/i? aeine?aeaeaiiy
aeeiiaa ia eaoaae?? iaaee/ii? a?ieia?? oa aaiaoeee i?ae ea??aieoeoaii
caa. eao. i?io. E.?. Eiaaeue/oe.** Ca iaaeaio iaoiaee/io ?
eiinoeueoaoeaio aeiiiiiao i?e i?iaaaeaii? aeine?aeaeaiue ai?noo
i?e?iaeaiaio?a a e?ia? aaoi? aaey/iee i?io. ?.A. Iacai?, a i?e aeeiiaii?
oeeoiaaiaoe/ieo aeine?aeaeaiue — i?io. E.?. Eiaaeue/oe.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy
aeena?oaoe?eiiai aeine?aeaeaiiy aeiiia?aeaeeny ia iaoeiai-i?aeoe/i?e
eiioa?aioe?? ? ieaioi? Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie (i. Ioea/aai,
1998); V c’?cae? Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie ( i. Oa?iii?eue,
1998); ia 1-io iaoe?iiaeueiiio eiia?an? Oe?a?ie c ?ioiieia??,
aea?aieia?? oa ?ioii?aaa?e?oaoe?? ( i. Aeoooa, 1998); ia?a?eaenoeo
eo?nao ?ioaeoe?ii?no?a ?aaii-O?aie?anueei? iaeano?
( 1997-1998), ia ni?eueiiio can?aeaii? eaoaae? aini?oaeueii? oa?ai?? ? 1
oa ?ioaeoe?eieo oai?ia ?aaii-O?aie?anueei? aea?aeaaii? iaaee/ii?
aeaaeai?? (5.05.99)

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o, 4 c ieo
o aeo?iaeueieo aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie. Ai?iaaaeaeaii o?e
?aoe?iiae?caoi?nuee? i?iiiceoe?? (? 17/ 2354 a?ae 3. 12. 1998, ?
6/2372 ? ? 7/2373 a?ae 30.07.99 ), ca?a?no?iaai? ?aaii-O?aie?anueeith
aea?aeaaiith iaaee/iith aeaaeai??th, aeaiee iaoiae e?eoaaiiy aianaii a
iaeaniee ?a?no? iaaeeei-a?ieia?/ieo oa iaaeeei-oaoi?/ieo i?iiiceoe?e a
i?aeoeeo ioi?iie caei?ia’y ( ?a?no? ? 74 , 1997).

No?oeoo?a ? ia’?i aeena?oaoe??. ?iaioa aeeeaaeaia ia 163 noi??ieao
iaoeiiieniiai oaenoo, ?ethno?iaaia 40 oaaeeoeyie ? 10 ?enoieaie.
Aeena?oaoe?y neeaaea?oueny ?c anooio, iaeyaeo e?oa?aoo?e, ?icae?eo
caaaeueiiee?i?/ieo oa niaoe?aeueieo iaoiae?a aeine?aeaeaiiy, 2-o
?icae?e?a aeanieo aeine?aeaeaiue, aiae?co ? ocaaaeueiaiiy ?acoeueoao?a
aeine?aeaeaiiy, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo
aeei?enoaieo aeaea?ae, yeee i?noeoue 242 aeaea?aea.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. ?iaioa aeeiioaaeanue o ee?i?oe?
?ioaeoe?eieo oai?ia, i?iaeaii?e eaai?aoi??? a?io?i?/ii? aeieia?? ? ia
eaoaae?? iaaee/ii? a?ieia?? oa aaiaoeee ?aaii-O?aie?anueei? iaaee/ii?
aeaaeai??.

Aeey aeinyaiaiiy iinoaaeaieo caaaeaiue ianoaaeaii 89 oai?eo ia aino?ee
aaiaoeo A a?eii a?ae 20 aei 60 ?ie?a, na?aae ieo 56 /ieia?e?a ( 62,9%)
oa 33 ae?iee ( 37,1%), ? 107 iaoe??io?a ?c aino?ei aaiaoeoii A a?eii
a?ae 20 aei 65 ?ie?a, na?aae ieo 55 /ieia?e?a ( 51,1% ) ? 52 ae?iee
(48,6%).

A eiio?ieueio a?oio uiaei a?io?i?/ieo e ?ioiieia?/ieo iieaciee?a oa?eoee
30 caei?iaeo in?a — aeiii??a e?ia?. C ieo o 20 — oe aecia/aany ??aaiue
eiio e?o?th a ne?iaaooe? e?ia?, a o 20-oe in?a /ieia?/i? noao? a?eii
25-35 ?ie?a aeeiioaaeeny oeeoiaaiaoe/i? aeine?aeaeaiiy.

Ae?aaiic aino?iai aaiaoeoo A /e A aenoaaeyee ia iniia? ee?i?ei —
ai?aeai?ieia?/ieo aeaieo. I?aeoaa?aeaeoaaee aaiaoeo A oeyoii aecia/aiiy
a ne?iaaooe? e?ia? ?aae?i?ioiiei aiae?cii aioe- HAV-IgM, a aaiaoeo A —
iayai?noth HBsAg, aioe- HBc-IgM, aioe-HBe-IgM.

Oi?io aaaeeino? oai?iae aecia/aee, aeoiaey/e c ioe?iee nooiaiy
caaaeueii? ?ioieneeaoe??, ?ioaineaiino? aeiaoyieoe?, ??aiy
a?ia?oa?iaioai??, ca?eueoaiiy ?ici???a ia/?iee ca e?eoa??yie iiaeaieie
Aethaa?ii A.O. ? Iiaeoeueeei ?.I., 1988.

A?aeiia?aeii aei aaaeeino? a??oniiai aaiaoeoo oa i?iaaaeaiiai e?eoaaiiy
oai?? ia aaiaoeo A aoee ?icae?eai? ia 4 a?oie , a oai?? ia aaiaoeo A ia
6 a?oi, ye iieacaii ia oaae. 1. E?o?th ea?aiiao oai?ei ?c
aaiaoeoii A /e A i?ecia/aany a eiiieaeniiio e?eoaaii? aeiaeaoeiai aei
caaaeueiii?eeiyoi? oa?ai?? ii 0,3 aea?/? ia aeaiue ( 0,6 ia aeiao)
i?ioyaii 10 aei?a, ii/eiath/e c 2-3-ai aeiy ia?aaoaaiiy a noaoe?iia?? (
c 3-4-ai aeiy aeiaoyie/iiai ia??iaeo ). Iaoe??ioai ?c ia?aaea?nieeaie
aioeaoaeiiao?? e?o?th ea?aiiao i?ecia/aany ii 0,3 o?e/? ia aeaiue ( 0,9
ia aeiao) i?ioyaii inoaii?o 10 aei?a canoiniaaiiai eo?no i?aaei?cieiio.

Noai ee?oeiiiai ?ioi?oaoo aea/aee ca aeiiiiiaith ?aaeoe??
?icaoeiooai?aiiy e?ioioeeo?a ca iaoiaeii N. Mendes, 1974.
Coaiiioeyoe?th oaio?e?i — iiaeoeueiaaieo e?ioioeeo?a aecia/aee ca
iaoiaeii S. Limatibul , 1978, noaiiioeyoe?th O-aeoeaieo ee?oei — ca
iaoiaeii Kerman et al., 1976. Aaeee? a?aioey?i? e?ioioeeoe ( AAE ), ye?
ooieoe?iiaeueii ? i?e?iaei?ie oeeoioiene/ieie ee?oeiaie ( Cae. E.I.,
Aooaiei A.E., 1985), i?ae?aoiaoaaee a iaceao, ye? aoee i?eaioiaeai?
aeey aecia/aiiy O- ee?oei.

Oaaeeoey 1

?iciiae?e oai?eo ia aaiaoeoe A ? A o a?aeiia?aeiino? aei i?iaaaeaiiai
e?eoaaiiy

I?iaaaeaia e?eoaaiiyA?oieAaceniaAacenia oa?ai?y +oai?eooa?ai?ye?o?y
ea?aiiaoi?aaei?cieii i?aaei?cieii ?

e?o?y ea?aiiaoAA ?c eaaeith oi?iith

1315—AA ?c na?aaeiueiaaaeeith oi?iith3031—AA ?c na?aaeiueiaaaeeith
oi?iith3030—AA ?c aaaeeith oi?iith

1113—AA ?c aaaeeith oi?iith ? ia?aaea?nieeaie aioeaoaeiiao??—1112

Aeey ioe?iee nooiaiy aeoeaaoe?? anueiai ianeao oeeoioiene/ieo E-ee?oei
cai?iiiiiaaii eiao?oe??io ?ioiiiai oeeoie?co ( E?Oe):

E?Oe = ??? 0-e,

aea 0-e?ioioeeoe ae?aaeai? aeanyoeiaei ae?iaii.

Aeey ioe?iee /anoee i?e?iaei?o oeeoioiene/ieo ee?oei a ii??aiyii? ?c
aioeo?eicaeaaeieie e?ea?aie cai?iiiiiaaii eiao?oe??io i?e?iaeiuei?
oeeoioiene/iino? ( EIOe):

EIOe = AAE : 0-e,

aea AAE ? 0-e ae?aaeai? o a?aenioeao aai a aeanyoeiaeo ae?iaao.

E?Oe ? EIOe ?ic?aoiaoaaee a aeeiai?oe? caoai?thaaiiy.

C iaoith ioe?iee ?ioiinoeioethth/iai aoaeoo a?ae canoinoaaiiy e?o?th
ea?aiiaoo ?ic?aoiaoaaee eiao?oe?aio ?ioiinoeioethth/i? ae??
(E?Ae), cai?iiiiiaaiee Ainiiaea?nueeei ?.ss. (1997):

E?Ae = (Oe2:Oe1) / (Oea2:Oea1),

aea Oe — ??aaiue O-e?ioioeeo?a o iaoe??io?a, e?eiaaieo ?ioiiiiaeoeyoi?ii
aei (1) ? i?ney (2) e?eoaaiiy; Oea — ??aaiue O-e?ioioeeo?a o
iaoe??io?a, ye? io?eioaaee aacenio oa?ai?th aei (1) ? i?ney (2)
e?eoaaiiy.

sseui E?Ae 1, oi i?aia?ao aieiae?? ?ioiinoeioethth/ith ae??th.

Neeaae ?ioiiaeiaoe?i?a ne?iaaoee e?ia? aecia/aee iaoiaeii ?aae?aeueii?
aeeooc?? ca iaoiaeii Mancini G. et al., 1965, a oee?eoethth/? ?ioii?
eiiieaene ( Oe?E ) iaoiaeii inaaeaeaiiy 3 % iie?aoeeaiae?eieai (
Iaioeeia A.A., 1987).

Oaaioeeoa?io aeoeai?noue iaeo?io?eueieo a?aioeioeeo?a aecia/aee
iaoiaeii, iienaiei Iaioeeiaei A.A. (1987), aea iiaeeo?eoaaee eiai a
oaeee niin?a, ui a?aioeioeeoe aeey iinoaiiaee ?aaeoe?? a?aee o?, ye?
a?aeae?eyee a?ae e?ioioeeo?a a a?aae??io? u?eueiino?. Ia 100 ee?oei o
iaceo i?ae?aoiaoaaee a?aeiini? iieacieee: oaaioeeoa?iee ?iaeaen (O?),
oaaioeeoa?ia /enei (O*), ?iaeaen aaeoa?eoeeaeiino? (?AI) oa aeoeai?noue
i??eiia?ieneaeace ca oeeoio?i?/iei iaoiaeii A?aoaia — Eiiey. Aaniethoi?
iieacieee ?ic?aoiaoaaee ia aaniethoia /enei iaeo?io?e?a (A*I) a 1 ii3
e?ia? ca iaoiaeii Aeaenaiae?iaa I.O. ? ni?aaao., 1988: aaniethoiee
iieaciee oaaioeeoa?ii? aeoeaiino? ( AIOA), aaniethoiee
iieaciee iiaeeiaiiy (AII), aaniethoiee iieaciee aaeoa?eoeeaeiino? (
AIA).

Aiae?c ?ioa?oacieo yaea? ee?oei ai?oae?th neeciai? iaieiiee ii?iaeieie
?ioa ?c i?ae?aooieii iieacieea noaoaaiai o?iiaoeio, ?iaeaeno
o?iiaoecaoe??, ?iaeaeno iaoieia?/ii ci?iaieo yaea? aeeiioaaee ca
iaoiaeeeaie Aeuoeiaiai A.Ae., 1975, Aaieiie E.I., 1980, 1990; Y?ai?aena
A.A., 1990; ioeeaiey?iiai ?iaeaeno ca iaoiaeeeith *aeeaeca I.A.,
Caoeaieiie I.A., 1988. ?ic?aoiaoaaany ?ioaa?aeueiee iieaciee —
ooieoe?iiaeueiee noai aaiioeio ( ONA), cai?iiiiiaaiee Neo/eeii A.I.
(1996):

ONA = ( I? Iss ?O) : ( NO Iss ),

aea I? — ioeeaiey?iee ?iaeaen, Iss — ii?iaeuei? yae?a, ?O — ?iaeaen
o?iiaoecaoe??, NO — noaoaaee o?iiaoei, Iss — ii?oieia?/ii ci?iai? yae?a.

Ai?no eiio e?o?th a ieaci? e?ia? aecia/aee iaoiaeii aeaeo?iiii? ai?n??
c ?ic?yaeii ieacie ia aia?ao? “ Plazmaquant ”.

C iaoith aeeoa?aioe?aeueii? ae?aaiinoeee aeiaoyieoeue an?i oai?ei
i?iaiaeeee oeueo?acaoeiaa aeine?aeaeaiiy aaiaoiiaie?aaoe/ii? ciie
/a?aaii? ii?iaeieie ia oeueo?acaoeiaiio oiiia?ao?/iiio neaia?? oeio
SonoScope — 30 ( I?ia//eia ), a ca iieacaiiyie i?iaiaeeeany
o?a?iaano?iaeoiaeaiineii?y, eiii’thoa?ia oiiia?ao?y.

Aeey ioe?iee noaio na?oeaai-noaeeiii? ae?yeueiino? i?iaiaeeeiny
aeaeo?iea?ae?ia?ao?/ia aeine?aeaeaiiy.

Oeeo?iaee iaoa??ae noaoenoe/ii ii?aoeueiaaiee, anoaiiaeai? ei?aeyoe?ei?
ca’ycee i?ae ie?aieie iieacieeaie, aecia/aiee nooi?iue aeinoia??iino?
??cieoeue i?ae iieacieeaie c aeei?enoaiiyi t-e?eoa??th No’thaeaioa ca
aeiiiiiaith iaeaoa i?eeeaaeieo i?ia?ai aeey noaoenoe/ieo ?ic?aooie?a ia
ia?niiaeueiiio eiii’thoa?? Acer Power — 486SX. Aeey ioe?iee
aeinoia??iino? aeaio na??e oeeoiaaiaoe/ieo aeine?aeaeaiue ( aei ? i?ney
e?eoaaiiy ) canoinoaaee ??cieoeaaee iaoiae noaoenoe/ieo ?ic?aooie?a (
Eaaiia TH.E., Iiai?aethe I.I., 1990 ).

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

I?iaiae?ciaaii ee?i?ei-a?io?i?/i? iieacieee, ?ioiiee noaoon,
oaaioeeoa?io aeoeai?noue iaeo?io?eueieo a?aioeioeeo?a, oeeoiaaiaoe/i?
iieacieee niiaoe/ieo ee?oei o oai?eo ia aaiaoeo A ? aaiaoeo A ia ii/aoeo
e?eoaaiiy, ii??aithth/e ?c iieacieeaie a caei?iaeo in?a. Aoaeoeai?noue
eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo i?iaiae?ciaaia
a aeeiai?oe? caoai?thaaiiy ca oeeie ae iieacieeaie, ii??aithth/e ?c
aaceniith oa?ai??th. ?ioiieia?/i? aeine?aeaeaiiy aeeiioaaeeny o?e/?: ia
2-3-e aeaiue o noaoe?iia?? ( aei i?ecia/aiiy e?o?th ea?aiiaoo ), /a?ac
10 aei?a ( i?ney eo?no e?o?th ea?a?iaoo) oa iaia?aaeiaei? aeienee.
Oai?eo ia aaiaoeo A ?c ia?aaea?nieeaie aioeaoaeiiao?? ianoaaeoaaee a
ia??iae iaeneiaeueieo iaoieia?/ieo i?iya?a ( aei canoinoaaiiy
i?aaei?cieiio), ca 10 aei?a aei a?aei?ie i?aaei?cieiio ( aei
i?ecia/aiiy e?o?th ea?aiiaoo) oa i?ney io?eiaieo eo?n?a i?aaei?cieiio ?
e?o?th ea?aiiaoo.

I?ae niinoa?aaeaiiyi ciaoiaeeeeny 89 oai?eo ia aaiaoeo A: 28 ?c eaaeith
oi?iith ? 61 ?c na?aaeiueiaaaeeith oi?iith. A eiiieaeniiio e?eoaaii?
e?o?th ea?aiiao io?eioaaee 15 oai?eo ?c eaaeith oa 31 ?c
na?aaeiueiaaaeeith oi?iith, a aacenio oa?ai?th io?eioaaee 13 iaoe??io?a
?c eaaeith oa 30 ?c na?aaeiueiaaaeeith oi?iith. A?oie ii??aiyiiy aoee
??aiicia/i? ca a?eii, noaooth ? ee?i?/ieie i?iyaaie oai?iae ia ii/aoeo
e?eoaaiiy.

Anoaiiaeaii, ui ia 3-4-e aeaiue aeiaoyie/iiai ia??iaeo a iaoe??io?a ?c
eaaeith oi?iith ?ioiieia?/i? iieacieee ia aeoiaeeee ca iaae?
o?c?ieia?/ieo eieeaaiue, ie??i iiioeyoe?? AAE, yea c?inea a 1,7 ?ac (
?<0,001). O oai?eo ?c na?aaeiueiaaaeeith oi?iith niinoa??aaeanue O-e?ioiiai?y ca ?aooiie iaaeinoaoiino? OO*e, ye? cieceeeny aaea?/? ( ?<0,001), aea e?euee?noue oeeoioiene/ieo ee?oei ia?aaaaeaea ii?io: ca?eueoeany ioe AAE a 1,7 ?ace ( ?<0,001) ? 0-e?ioioeeo?a a 1,2 ?ace ( ?<0,001). Ci?ie ni?aa?aeiioaiiue i?ae ?ioiioeeoaie ??cieo eean?a a?aeia?aaeaee ?ioaa?aeuei? ?ioiieia?/i? eiao?oe??ioe, aaee/eia yeeo ei?aethaaea ?c oi?iith aaaeeino? oai?iae: ???, r=0,715; E?Oe, r=0,873; EIOe, r= -0,826. I?e eaae?e oi?i? aaiaoeoo A c?inoaa o?eueee EIOe, ui na?ae/eei i?i ia?aaaaeio aeoeaaoe?th i?ioean?a i?e?iaeiuei? oeeoioiene/iino?, a i?e na?aaeiueiaaaee?e c?inoaee ???, E?Oe oa EIOe, ui aeacoaaei ia aaeain i?ae niaoeeo?/ieie oa ianiaoeeo?/ieie /eiieeaie i?ioea??oniiai ?ioi?oaoo. A?aeiia?aeii aei oi?ie aaaeeino? aaiaoeoo c?inoaa ??aaiue IgM oa Oe?E. Ia ii/aoeo aeiaoyie/iiai ia??iaeo niinoa??aaeanue iaeo?iiai?y, yea ni?e/eieea cieaeaiiy aaniethoieo iieaciee?a oaaioeeoico ( AIOA, AII, AIA), cie?aia AIA o oai?eo ?c eaaeith oi?iith cieceany a 1,8 ?ace (p<0,01). A iaoe??io?a ?c na?aaeiueiaaaeeith oi?iith cieaeoaaeeny ye a?aeiini?, oae ? aaniethoi? iieacieee oaaioeeoico, a oaeiae ? aeoeai?noue i??eiia?ieneaeace. O ieo iieaciee AIA cieceany, ii??aiyii ?c ii?iith, a 3,5 ?ace ? noaiiaea anueiai 28,8 % a?ae iieacieea a a?oi? aeiii??a ( 0,86 0,09104/ii3 i?ioe 2,980,35104/ii3, p<0,001 ). Oeeoiaaiaoe/ieie iaoiaeaie ianoaaeaii 35 /ieia?e?a a?eii 25 -35 ?ie?a oai?eo ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith ? anoaiiaeee ca?eueoaiiy e?eueeino? ee?oei ?c iaoieia?/ii ci?iaieie yae?aie oa ?c yae?aie, ye? i?noeee noaoaaee o?iiaoei, a iieaciee ONA noaa ieae/ei ca ii?io a 4,3 ?ace (p<0,001). Oea na?ae/eei i?i aeac?ioaa?aoe?th i?ioean?a ?aae?caoe?? niaaeeiai? ?ioi?iaoe?? oa ca?eueoaiiy /enea iaaeeoo?caeaoieo ee?oei. O ca’yceo c oeeoie?oe/iei neiae?iiii eiioeaio?aoe?y eiio e?o?th o oai?eo aoea aeuith ca ii?io: c eaaeith oi?iith - 1,410,05 ieiieue/e (p<0,001), a c na?aaeiueiaaaeeith - 2,48 0,07 ieiieue/e i?ioe 1,030,04 ieiieue/e o aeiii??a (p<0,001). I?ae aieeaii eiiieaeniiai e?eoaaiiy ?c aeeth/aiiyi e?o?th ea?aiiaoo, ii??aiyii ?c aaceniith oa?ai??th, anoaiiaeaii, ui o oai?eo ?c na?aaeiueiaaaeeith oi?iith aaiaoeoo A i?aiaioia e?eca ianoaaaea ia 2 aei? ?ai?oa (p<0,05), ciaiooaaeeny i?iyae anoaiiaaaaoaoeaiiai neiae?iio ? aeyaeyeeny iaia?aaeiaei? aeienee o?eueee a 6,4% i?ioe 13,3% oai?eo, aea nei?i/aiiy oa?i?io aeiaoyie/iiai ia??iaeo ia a?aeaoeiny. Iie?aueany ?ioiiee noaoon o oai?eo, ye? io?eioaaee e?o?th ea?aiiao: o an?o iaoe??io?a ca?eueoeany ioe AAE ? iia’ycaiee c iei EIOe, cieceany ??? oa E?Oe; ??aaiue Oe?E a na?aaeiueiio aeey an?o oai?eo ?c aaiaoeoii A cieceany ia 13,7 IAe (p<0,001). O iaoe??io?a ?c na?aaeiueiaaaeeith oi?iith i?aeaeueeany oaaioeeoa?ia aeoeai?noue iaeo?io?e?a ca ?yaeii iieaciee?a: c?inoaee O?, O*, ?AI, aeoeai?noue II; ca?eueoeeeny AIOA, AII, a AIA a 1,6 ?ace ia?aaeuoaaa aiaeia?/iee iieaciee o oai?eo, ye? io?eioaaee eeoa aacenio oa?ai?th (p<0,001). Anoaiiaeaii, ui i?ae aieeaii e?o?th ea?aiiaoo iie?aueany ooieoe?iiaeueiee noai aaiioeio niiaoe/ieo ee?oei, a ONA c??n a 1,7 ?ace (p<0,01) ca ?aooiie ca?eueoaiiy e?eueeino? ee?oei ?c ii?iaeueieie yae?aie ? ciaioaiiy ee?oei, ye? i?noeee a yae?ao aaoa?ii?eiioe/io O - o?iiiniio. I?ney 10-oe aeaiiiai aaeeaaiiy e?o?th ea?aiiaoo oai?eie ?c aaiaoeoii A eiioeaio?aoe?y eiio a ne?iaaooe? e?ia? a na?aaeiueiio noaiiaeea 0,2980,011 iiieue/ e, a iciae ?ioieneeaoe?? ia aeieeaei a aeiaeiiai oai?iai. Ianoaaeaii 107 iaoe??io?a ?c aino?ei aaiaoeoii A: 60 ?c na?aaeiueiaaaeeith oi?iith, 24 ?c aaaeeith oa 23 ?c aaaeeith oi?iith, a yeeo aeieeee ia?aaea?nieee aioeaoaeiiao??. Iaeia /anoeia oai?eo io?eioaaea e?o?th ea?aiiao: 30 ?c na?aaeiueiaaaeeith, 13 ?c aaaeeith oi?iith oa 12 ?c ia?aaea?nieeaie aioeaoaeiiao??, a ae?oaa - aacenio oa?ai?th, a?aeiia?aeii a?oie ii 30, 11 ? 11 iaoe??io?a. A?oie ii??aiyiiy aoee ??aiicia/i? ca a?eii, noaooth oa ee?i?/ieie i?iyaaie oai?iae ia ii/aoeo e?eoaaiiy. O an?o oai?eo ia aaiaoeo A ia 3-4 aeaiue aeiaoyie/iiai ia??iaeo, ii??aiyii ?c caei?iaeie iniaaie, ci?ie ?ioiiiai noaoono iaee a iniiaiiio iaeiioeiiee oa?aeoa?, aea aeeaeia ci?i caeaaeaea a?ae oi?ie aaaeeino?: ciaiooaaeany iiioeyoe?y O-e?ioioeeo?a ca ?aooiie OO*e, a c?inoaee ioee 0-e?ioioeeo?a ? O-aeoeaieo ee?oei. E?euee?noue AAE c?inoaea o?eueee o oai?eo ?c na?aaeiueiaaaeeith oi?iith. Iniaeea?noth oai?eo ?c ia?aaea?nieeaie aioeaoaeiiao?? aoei oa, ui aoea cieaeaiith e?euee?noue AAE ? O-aeoeaieo ee?oeie, a ca?eueoaiei ioe A-e?ioioeeo?a. A?aeiia?aeii aei oi?ie aaaeeino? oai?iae c?inoaa ??aaiue IgM ? Oe?E. Ioe?ieoe ci?ie ni?aa?aeiioaiue e?ioioeeo?a ??cieo eean?a aeicaieyee ?ioaa?aeuei? ?ioiieia?/i? eiao?oe??ioe, aaee/eia yeeo ei?aethaaea ?c oi?iith aaaeeino? oai?iae: ???, r=0,741; E?Oe, r=0,876; EIOe, r= -7,84. sse aeaeii ia ?en. 1, ??? o oai?eo c na?aaeiueiaaaeeith oi?iith c?inoaa aei 4,03, ?c aaaeeith oi?iith - aei 4,94, a a iaoe??io?a ?c ia?aaea?nieeaie aioeaoaeiiao?? aoa iaeaeuei - 7,48. E?Oe c?inoaa, a?aeiia?aeii aei 1,65, ? 2,03, a iaeaeuei aoa a inoaii?e a?oi? - 3,07. EIOe, iaaiaee, ciaioeany, a?aeiia?aeii aei 0,56 ? 0,43, a iaeieae/ei aeyaeany o oeo, ye? iaee ia?aaea?nieee aioeaoaeiiao?? - 0,35. Oaea cieaeaiiy EIOe i?e aaiaoeo? A, ia a?aei?io a?ae oai?eo ia aaiaoeo A ( aeea. ?en. 1), aeaco? ia iaaeinoaoi? iaoai?cie ianiaoeeo?/iiai i?ioea??oniiai ?ioi?oaoo ia oe? ia?aaaaeath/i? aeoeaaoe?? niaoeeo?/ii? eaiee ee?oeiiiai ?ioi?oaoo. wmetafile8? ??*?? ?5???????? ???????yyy???????????? 0??? ????'yy??? ??????? ????yyy???? ???????'yy??? ????yyy???? ???????0???????'yy??? ????yyy???? ???????0???????'yy??? ????yyy???? ???????+z?????ue??aaa?yy???-?????u????????????-???? aaa????????????$?O?Iw?u?o?AE?O????ue??yyy??????-?? ???????? yyy???????????$?w?u?s??o??o?AE?w?u????$?o?AE?o???O?o?AE? ???u?????????????-??????????AE?o????yyy????????u?w? ???E? ???y?????E?M????ae????I?|??? ???I?«???V???N?U??? ‘???O????I???u?w????I???ae?¦????o?ae???O? I????ae?u???AE?o????O????AE?o?????o????E? ???????E?M??? ?M???I?|??? ?|???I?«??? ?¬???N?U????Y???O????????u?w?????s????ae?¦? ????¤????O?I?????I????AE?o?????o????u?w????AE?o??? ?O????Y?w????®?o?????????A?v????—?o????c????F ?v?????o????‰????†?u????g?o????o????i?u????P?o ????V????L?t????8?o????=????.?t???? ?o????$?????s?????o????????ue??????????-????? ???? ??????????????????$?O?Iw?u?o?AE?O????u????????????- ??????????$?w?u?s??o??o?AE?w?u????$?o?AE?o???O?o?AE????u ?????????????-??????????u?w????yyy????????I???u ?w????th?w????y??????????ae????ae???? ??? ???V??? V??? ‘???‘???I???I???uoy??????1/4???I????Arial Cyr?——???-? ???2?????1?? ???2Ae????2?? ???2 ue????3?? ???25???4?? ???2o???5?? ???2«???6?????O????I???I???O???o?ae??? o?e???ae?u???ae?y???O????O? ???2u?i???EIOe?? ?? ???2ae????E?Oe???? ???2O????????? ??5???B???(??????????????? ????????????????????KKK?ff1/2y™™°?™™?ff1. Caei?ia? iniae. 2. Oai?? ia aaiaoeo A ?c eaaeith oi?iith. 3. Oai?? ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith. 4. Oai?? ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith. 5. Oai?? ia aaiaoeo A ?c aaaeeith oi?iith. 6. Oai?? ia aaiaoeo A ?c aaaeeith oi?iith ? ia?aaea?nieeaie aioeaoaeiiao??. A?aeiia?aeii aei oi?ie aaaeeino? oai?iae cieaeoaaeeny iieacieee oaaioeeoa?ii? aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a ye a?aeiini?, oae ? aaniethoi?, a iaea?eueoa ?ioaa?aeueiee AIA. O oai?eo ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith AIA cieceany a 3,7 ?ace ( p<0,001), a ?ac? aaaeei? oi?ie aaiaoeoo A a 5 ?ac ( ?<0,001 ), a a iaoe??io?a ?c ia?aaea?nieeaie aioeaoaeiiao?? ia oe? eiiiainaoi?ii? iaeo?io?e?? cieaeoaaany ia oae ??cei - a 3,2 ?ace ( p<0,001). Ii?ooaiith aaeoa?eoeeaeii? ooieoe?? iaeo?io?e?a a?aeiia?aeaei cieaeaiiy aeoeaiino? II, a nooi?iue aeoeaiino? oa?iaioo iaea ei?aeyoeaiee ca’ycie ?c iieacieeii ?AI ( r=0,649). O oai?eo ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith anoaiiaeaia cia/ia ii?ooaiiy ooieoe?iiaeueiiai noaio aaiioeio niiaoe/ieo ee?oei: iieaciee NO c??n aaea?/? (p<0,01), ?ICss cieceany aaea?/? (p<0,01), a a ?acoeueoao? ?ioaa?aeueiee iieaciee ONA cieceany iaeaea a 10 ?ac (p<0,001). Anoaiiaeaii, ui oeeoie?oe/iee neiae?ii ni?e/eith? i?aeaeuaiiy ??aiy eiio e?o?th a ne?iaaooe? e?ia?: a iaoe??io?a ?c na?aaeiueiaaaeeith aei 2,590,06 ieiieue/e (p<0,001), a ?c aaaeeith oi?iith aei 3,420,08 ieiieue/e (p<0,001) i?ioe 1,03 0,04 ieiieue/e o caei?iaeo in?a. Iaeiae, o a?oi? iaoe??io?a, ye? io?eioaaee i?aaei?cieii, ??aaiue eiio cieceany a 1,6 ?ace ( 0,630,06 ieiieue/e, p<0,001), ?iia??ii /a?ac i?aeaeuaiee eiai ee??ain ?c e?ia? i?ae aieeaii AEN. Ii??aithth/e aoaeoeai?noue eiiieaeniiai e?eoaaiiy ?c aeeth/aiiyi e?o?th ea?aiiaoo c aaceniith oa?ai??th, ca aeaieie ee?i?ei-a?io?i?/iiai ianoaaeaiiy anoaiiaeaii, ui o oai?eo ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith i?aiaioia e?eca ianooiaea ia 2 aei? ?ai?oa ? ia 6,5 aeiy nei?ioeany aeiaoyie/iee ia??iae, a oa?i?i ia?aaoaaiiy o noaoe?iia?? - ia 6,6 aeiy. O iaoe??io?a ?c ia?aaea?nieeaie aioeaoaeiiao??, yeei i?ecia/aee i?aaei?cieii, oa?i?i ia?aaoaaiiy o noaoe?iia?? nei?ioeany ia 7,2 aeiy. Ia aeyaeaii iiceoeaiiai aieeao ia o?eaae?noue aeiaoyie/iiai ia??iaeo o oai?eo ia aaaeeo oi?io aaiaoeoo A. O an?o iaoe??io?a ciaiooaaeeny i?iyae anoaiiaaaaoaoeaiiai neiae?iio. Aei e?eoaaiiy aiie aeyaeyeeny a 36,9 % oai?eo ?c na?aaeiueiaaaeeith ? aaaeeith oi?iaie, oa a 100 % in?a ?c ia?aaea?nieeaie aioeaoaeiiao??. A ia??iae ?aiiuei? ?aeiiaaeanoeaioe??, ii??aiyii ?c oai?eie, ye? io?eioaaee aacenio oa?ai?th, aaaaoaoeai? ?iceaaee aeyaeyeeny o?eueee o 7,0 % i?ioe 17,0 % iaoe??o?a ?c na?aaeiueith oa aaaeeith oi?iaie, a a oeo, ye? io?eiaee eo?n i?aaei?cieiio ? e?o?th ea?aiiaoo, - a 41,7 % i?ioe 72,7 % oai?eo. ??aaiue a?e??oa?io o iaoe??io?a ?c na?aaeiueiaaaeeith oi?iith i?ney eo?no e?o?th ea?aiiaoo, ii??aiyii ?c oai?eie, ye? io?eiaee aacenio oa?ai?th, ciaiooaaany ia 17,23 ieiieue/e (?<0,001 ), a a iaoe??io?a ?c ia?aaea?nieeaie aioeaoaeiiao?? i?ney eo?no i?aaei?cieiio ? e?o?th ea?aiiaoo a?e??oa?i ciaioeany ia 6,60 ieiieue/e (?<0,001 ). O oai?eo ia aaaeeo oi?io aaiaoeoo A a?i ciaioeany o?eueee ia?aae aeieneith aei 17,181,10 ieiieue/e i?ioe 23,96 1,45 ieiieue/e (?<0,001 ). Anoaiiaeaii cieaeaiiy aeoeaiino? AnAO o an?o a?oiao oai?eo ?c aaiaoeoii A, ui aeaco? ia ciaioaiiy noaio a?iien?? ia/?ieiaeo ee?oei, noaa?e?caoe?th i?oioiiae??aeueieo iaia?ai. Aeyaeaii ?ioiiiiaeoethth/ee oa?aeoa? ae?? i?aia?aoo. Noeioethth/ee eiai aieea noinoaaany O-e?ioioeeo?a ? AAE, e?euee?noue yeeo o ia?eoa?e/i?e e?ia? c?inoaea, aea oaeiae c?inoaea noaiiioeyoe?y OO*e, ui ni?eyei noi?an?? ?ioiieia?/ieo ?aaeoe?e, i?ioa o ??cieo a?oiao iaoe??io?a ?c aaiaoeoii A ae?aaeai?noue ci?i aoea iaiaeiaeiaith. O oai?eo ?c na?aaeiueiaaaeeith oi?iith c?inoaea iiioeyoe?y O-e?oioeeo?a ia 5,33 % ( ?<0,05), AAE ia 4,46 % ( ?<0,05 ), a noaiiiiioeyoe?y OO*e ia 1,33 % (?<0,05 ). O oai?eo ?c aaaeeith oi?iith ca?eueoeeanue o?eueee iiioeyoe?y OO*e ia 0,91 % (?<0,05 ), a a oeo, ye? iaee ia?aaea?nieee aioeaoaeiiao??, i?ney eo?no i?aaei?cieiio ? e?o?th ea?aiiaoo c?inee o?eueee AAE ia 3,6 % ( ?<0,05). I?ney canoinoaaiiy e?o?th ea?aiiaoo, ii??aiyii ?c oai?eie ia aaceni?e oa?ai??, cia/ieo iiceoeaieo ci?i caciaee ?ioaa?aeuei? ?ioiieia?/i? eiao?oe??ioe: ??? oa E?Oe ciaiooaaeeny, a EIOe c?inoaa. ??? ciaiooaaany o iaoe??io?a ?c na?aaeiueiaaaeeith oi?iith - 5,03 i?ioe 5,82, ?c aaaeeith - 5,44 i?ioe 6,02, a a oai?eo ?c ia?aaea?nieeaie aioeaoaeiiao?? i?ney eo?no i?aaei?cieiio oa e?o?th ea?aiiaoo - 2,25 i?ioe 2,47. Oae naii cieaeoaaany E?Oe: o oai?eo ?c na?aaeiueiaaaeeith oi?iith - 1,57 i?ioe 2,15, ?c aaaeeith - 1,96 i?ioe 2,39, a a iaoe??io?a i?ney eo?no i?aaei?cieiio oa e?o?th ea?aiiaoo - 0,65 i?ioe 0,80. I?ioeeaaeieo ci?i caciaa EIOe, oiaoi a?i c?inoaa: a ?ac? aaiaoeoo A ?c na?aaeiueiaaaeeith oi?iith - aei 0,76 i?ioe 0,62; ?c aaaeeith - 0,53 i?ioe 0,48; o oai?eo i?ney eo?no i?aaei?cieiio ? e?o?th ea?aiiaoo - 0,60 i?ioe 0,41. ?ioiinoeioethth/ee aoaeo ia’?eoeaii a?aeia?acea E?Ae, yeee o oai?eo ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith aei??aithaaa 1,1. I?ae aieeaii i?aia?aoo o an?o oai?eo ?c aaiaoeoii A cieceany ??aaiue Oe?E a na?aaeiueiio ia 15,31 IAe ( ?<0,05). Anoaiiaeaii noeioethth/ee aoaeo eiiieaeniiai e?eoaaiiy ?c e?o??i ea?aiiaoii ia oaaioeeoa?io aeoeai?noue iaeo?io?eueieo a?aioeioeeo?a: O?, ?AI oa II i?aeaeooaaeeny o iaoe??io?a ?c na?aaeiueiaaaeeith ? aaaeeith oi?iaie aaiaoeoo A. E?euee?noue iaeo?io?e?a a na?aaeiueiio aeey an?o oai?eo ia aaiaoeo A ca?eueoeeany ia 0,98103 / ii3 (?<0,05), a a ?acoeueoao? c?inee aaniethoi? iieacieee oaaioeeoico - AIOA, AII ? AIA. Inoaii?e iieaciee, ye aeaeii ia ?en.2, c?inoaa cie?aia a eiaei?e a?oi? oai?eo ia aaiaoeo A, a a na?aaeiueiio aeey an?o iaoe??io?a ca?eueoeany a 1,7 ?ace ( ?<0,001). Iie?auaiiy aaniethoieo iieaciee?a oaaioeeoico a iaoe??io?a ?c aaiaoeoii A, ye? io?eioaaee i?aaei?cieii ? e?o?th ea?aiiao, a?aeaoeiny o cia/i?e i??? ca ?aooiie ca?eueoaiiy e?eueeino? iaeo?io?e?a o ia?eoa?e/i?e e?ia?, a ia no?eueee ca ?aooiie aeoeaaoe?? ooieoe?? naieo oaaioeeo?a. wmetafile8? ??‘???5???????? ???????yyy???????????? y?»??? ????'yy??? ??????? ????yyy???? ???????'yy??? ????yyy???? ???????y?»???????'yy??? ????yyy???? ???????y?»???????ue??yyy??????-?????u????????????-???? yyy???????????????????$?J??g?gN?J?N?J?????u???????? ?????-?????????u?????????????-????ue??yyy??????-????'y y??? ????-?????-??????????? yyy????O?g?J????»?¶W?^?????J????yyy???????????? ??g???”?J????”?g???v?J????v?g???W?J????W?g??? 9?J????9?g????J?????g???-????-????'yy??? ????-?????-????yyy???? yyy????y?»???????»?¶W?^???u????????????-????????? ?J?????????????g???N?g???N?J?????J????-????- ????'yy??? ????-?????-????yyy???? yyy????y?»???????-????-????'yy??? ????-?????-????yyy???? yyy????u?¶?????-????-????'yy??? ????-?????-????yyy???? yyy????N?h?J????-????-????'yy??? ????-?????-????yyy???? yyy????N?i?J????u????????????-?????????ue??yyy?yy???- ??????????????????$?_?????N?_?N?_?????ue??aaa?yy???- ?????????? aaa????$?¦?j?A?j?A?N?¦?N?¦?j????$?i???N?i?N?i?????$?5C?Q C?QN?5N?5C????-????-????'yy??? ????-?????-????yyy???? aaa????N?h?J????-????-????'yy??? ????-?????-????yyy???? aaa????y?»???????u?????????????-??????????J???????? ????N?J????uoy??????1/4???I??? Arial Cyr?[[???-????N?F????N?N??????F??????N????”?F????”? N????v?F????v?N????W?F????W?N????9?F????9?N?????F? ????N????N?J????N?g???O?J????I?J????O?‘????I?‘?? ??O?U????I?U????O? ???I? ???O?g???I?g???-????-????u??????1/4????"System? ???-????'yy??? ????-????-?????-????yyy???? aaa????u?¶?????-????-????-????'yy??? ????-????-?????-????yyy???? aaa????O?h?J????-????-????-????'yy??? ????-????-?????-????yyy???? aaa????Oe?m?E????ue?????yy???-??????????u?????yyy????- ??????????›?µ?5???B???(??????????????? ???????????????????????yyy?DDY???DDa??DDI?DD,??????ae ?m????-????????? ???$??? Oai??, ye? io?eioaaee e?o?th ea?aiiao Oai??, ye? io?eioaaee aacenio oa?ai?th ?en. 2. Aaniethoiee iieaciee aaeoa?eoeeaeiino? ( AIA) o oai?eo ia aaiaoeo A, ye? io?eioaaee e?o?th ea?aiiao. 1. Oai?? ia aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith. 2. Oai?? ia aaiaoeo A ?c aaaeeith oi?iith. 3. Oai?? ia aaiaoeo A ?c aaaeeith oi?iith ? ia?aaea?nieeaie aioeaoaeiiao??. * - iicia/aii aeinoia??io ??cieoeth i?ae iieacieeaie o oai?eo, ui io?eioaaee e?o?th ea?aiiao oa o caei?iaeo in?a. ** - iicia/aii aeinoia??io ??cieoeth i?ae iieacieeaie o oai?eo, ui io?eioaaee e?o?th ea?aiiao ? a iaoe??io?a ia aaceni?e oa?ai??. A ee?i?oe? aaiaoeoo A niinoa??aaeeny noiooi? aaeoa??aeuei? oneeaaeiaiiy: aino?a iiaaiii?y, i?iaea?i?y oa caaino?aiiy o?ii?/iiai oieaoeenoeoo, a?iio?oo, i??eiiao?eoo, a?ia?a?oo, ia?iaeiioico. Na?aae an?o iaoe??io?a, ye? io?eioaaee a eiiieaeniiio e?eoaaii? e?o?th ea?aiiao, aaeoa??aeuei? oneeaaeiaiiy aeieeaee ??aeoa - a 16,3 % i?ioe 40,4 % oai?eo, ye? io?eioaaee o?eueee aacenio oa?ai?th. sseui ie?aii ioa?aeoa?ecoaaoe a?oio oai?eo, ye? io?eioaaee i?aaei?cieii, oi aaeoa??aeuei? oneeaaeiaiiy aeieeaee a 81,8 % iaoe??io?a ia aaceni?e oa?ai??, iacaaaeath/e ia i?io?eaeoe/ia canoinoaaiiy aioea?ioee?a, a a aiaeia?/ieo oai?eo, ye? io?eioaaee e?o?th ea?aiiao - o?eueee a 41,7 % . I?ae aieeaii e?eoaaiiy ?c e?o??i ea?aiiaoii, iie?auoaaeeny oeeoiaaiaoe/i? iieacieee niiaoe/ieo ee?oei: ciaiooaaeanue e?euee?noue ee?oei, ui i?noeea aaoa?ii?eiioe/io O - o?iiiniio ? c?inoaea e?euee?noue ee?oei ?c ii?iaeueieie yae?aie, a ?ioaa?aeueiee iieaciee ONA a 1,7 ?ace ia?aaeuoaaa aiaeia?/iee iieaciee o iaoe??io?a, ui io?eioaaee o?eueee aacenio oa?ai?th (p<0,05). Eiioeaio?aoe?y eiio e?o?th a ne?iaaooe? e?ia? i?ney aeanyoeaeaiiiai aaeeaaiiy 0,6 ia aeiao e?o?th ea?aiiaoo a na?aaeiueiio aeey oai?eo ?c na?aaeiueith oa aaaeeith oi?iith aeinyaea 0,292 0,016 iiieue /e, a a oai?eo, ye? io?eioaaee 0,9 ia aeiao ( iaoe??ioe ?c ia?aaea?nieeaie aioeaoaeiiao??, ye? io?eioaaee eo?n i?aaei?cieiio ? e?o?th ea?aiiaoo) - 0,481 0,036 iiieue /e, i?e oeueiio iciae ?ioieneeaoe?? ia aeieeaei. Io?eiai? ?acoeueoaoe aeine?aeaeaiue na?ae/aoue i?i iiaeeea?noue canoinoaaiiy e?o?th ea?aiiaoo a eiiieaeniiio e?eoaaii? oai?eo ia aaiaoeoe A ? A ?c ??cieie oi?iaie aaaeeino? c iaoith iioei?caoe?? ?ioiii? a?aeiia?ae? a oiiaao ?ioaeoe?eiiai i?ioeano, onoiaiiy i?iya?a anoaiiaaaaoaoeaiiai neiae?iio, iiia?aaeaeaiiy aaeoa??aeueieo oneeaaeiaiue, noeioeyoe?? i?ioean?a naiiaaiaco. AENIIAEE 1. O oai?eo ia aaiaoeo A aeyaeaii ieiath/? ii?ooaiiy ?ioiiiai noaoono, oaaioeeoa?ii? aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a ? ooieoe?iiaeueiiai noaio aaiioeio niiaoe/ieo ee?oei. 2. O iaoe??io?a ?c aino?ei aaiaoeoii A niinoa??aa?oueny ii?ooaiiy ee?oeiiiai oa aoii?aeueiiai ?ioiiiai noaoono, i?eai?/aiiy aeoeaiino? iaeo?io?eueieo a?aioeioeeo?a, cieaeaiiy ooieoe?iiaeueiiai noaio aaiioeio niiaoe/ieo ee?oei. Ae?aaeai?noue, aeeaeia ? no?ee?noue oeeo i?ioean?a caeaaeaoue a?ae oi?ie aaaeeino? oai?iae. 3. Eiiieaenia e?eoaaiiy oai?eo ia aaiaoeo A ?c canoinoaaiiyi e?o?th ea?aiiaoo i?eaiaeeoue aei ca?eueoaiiy e?eueeino? aaeeeeo a?aioey?ieo e?ioioeeo?a oa cieaeaiiy ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a, iie?auaiiy iieaciee?a oaaioeeoico ? ooieoe?iiaeueiiai noaio aaiioeio niiaoe/ieo ee?oei, ciaioaiiy i?iya?a anoaiiaaaaoaoeaiiai neiae?iio, aea ia aieeaa? ia o?eaae?noue aeiaoyie/iiai ia??iaeo. 4. Eiiieaenia e?eoaaiiy oai?eo ?c e?o??i ea?aiiaoii ia aaiaoeo A ? aoaeoeai?oei, i?ae aacenia oa?ai?y: o iaoe??io?a ?c na?aaeiueiaaaeeith oi?iith nei?i/oth?oueny o?eaae?noue oa?i?i?a aeiaoyie/iiai ia??iaeo ? noaoe?iia?iiai e?eoaaiiy ia 6-7 aei?a, a iaoe??io?a, ye? io?eioaaee i?aaei?cieii, oa?i?i noaoe?iia?iiai e?eoaaiiy nei?ioeany ia 7,2 aeiy; oaeaeoa ianooia? ?aa?an ee?i?/ieo neiioii?a oai?iae ? ii?iae?caoe?y a?io?i?/ieo iieaciee?a. O an?o a?oiao oai?eo ciaioo?oueny /enei oneeaaeiaiue ? iani?eyoeeaeo iane?aee?a, cieeathoue i?iyae anoaiiaaaaoaoeaiiai neiae?iio. 5. E?eoaaiiy c e?o??i ea?aiiaoii oai?eo ia aaiaoeo A ia? ?ioiiiiaeoethth/ee aoaeo, yeee iaeae?aaeai?oee o iaoe??io?a ?c na?aaeiueiaaaeeith oi?iith aaiaoeoo A: ca?eueoothoueny iiioeyoe?? O-ee?oei, oaio?e?i/ooeeaeo e?ioioeeo?a, aaeeeeo a?aioey?ieo e?ioioeeo?a, ciaioo?oueny ??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a. 6. A ?acoeueoao? eiiieaeniiai e?eoaaiiy ?c e?o??i ea?aiiaoii i?aeaeuothoueny eiao?oe??ioe ?ioiinoeioethth/i? ae?? oa i?e?iaeiuei? oeeoioiene/iino?, ciaioothoueny ?ioii?aaoeyoi?iee ?iaeaen ? eiao?oe??io ?ioiiiai oeeoie?co. Oe? iieacieee iiaeooue aeei?enoiaoaaoeny aeey ioe?iee aoaeoeaino? ?ioiiiiaeoethth/i? oa?ai??. 7. Canoinoaaiiy e?o?th ea?aiiaoo a e?eoaaii? aaiaoeoo A iie?auo? ooieoe?th iiaeeiaiiy ? ia?ao?aaethaaiiy i?e?ii?aai?ci?a iaeo?io?eueieie a?aioeioeeoaie, ui noi?iaiaeeoueny c?inoaiiyi aeoeaiino? i??eiia?ieneaeace. 8. Aeei?enoaiiy e?o?th ea?aiiaoo a e?eoaaii? oai?eo ia aino?ee aaiaoeo A iie?auo? ooieoe?iiaeueiee noai aaiioeio niiaoe/ieo ee?oei ca ?aooiie ciaioaiiy e?eueeino? ee?oei ?c aaoa?ii?eiioe/iith O-o?iiiniiith ? ee?oei ?c iaoieia?/ii ci?iaieie yae?aie. Aeacaiee iieaciee iiaea neoaeeoe aeiaeaoeiaei e?eoa???i aoaeoeaiino? e?eoaaiiy. IA?AE?E IIOAE?EIAAIEO I?AOeUe CA OAIITH AeENA?OAOe?? 1. A?eaeae ?.A. Aeeiai?ea iieaciee?a ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo a oai?eo ia a??oni? aaiaoeoe A ? A i?ae aieeaii eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo // Aaeeoeueeee e?ea?nueeee a?niee. - 1997. - O. 4, ?4. - N. 80 - 82. 2. A?eaeae ?.A., Aeeeee A.I. Iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy ?ioiiiiaeoethth/eo aeanoeainoae nieae e?o?th a ee?i?/i?e i?aeoeoe? // Aaeeoeueeee e?ea?nueeee a?niee. - 1998. - O.5, ? 1. - N. 109 - 112. 3. A?eaeae ?.A. Ei?aeoe?y ii?ooaiue ooieoe?iiaeueiiai noaio aaiioeio o oai?eo ia a??oni? aaiaoeoe A ? A ca aeiiiiiaith e?o?th ea?aiiaoo // Aaeeoeueeee e?ea?nueeee a?niee. - 1998. - O.5, ?3. - N. 30 - 31. 4. A?eaeae ?.A. Ci?ie oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a o oai?eo ia a??oni? aaiaoeoe A ? A i?ae aieeaii eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo // ?ioaeoe?ei? oai?iae. - 1999. - ?1. - N. 16-19. 5. A?eaeae ?.A. Ci?ie iieaciee?a oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a o oai?eo ia aaiaoeo A i?ae aieeaii eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo // A?eia? iniaeeaino? ?ioaeoe?eieo oai?ia. Iaoa??aee iaoeiai-i?aeoe/ii? eiioa?aioe?? ? ieaioio Anioe?aoe?? ?ioaeoe?ii?no?a Oe?a?ie. - Ioea/aai, 1998. - N. 34 - 35. 6. A?eaeae ?.A. Aeeiai?ea iieaciee?a ?ioi?oaoo o oai?eo ia aaiaoeo A i?ae aieeaii eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo // Aeooaeuei? ieoaiiy ee?i?/ii? ?ioaeoieia??. Iaoa??aee V - c’?caeo ?ioaeoe?ii?no?a Oe?a?ie. - Oa?iii?eue: Oe?iaaeeieaa. - 1998. - N. 31 - 32. 7. A?eaeae ?.A. Aieea eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo ia ?ioiieia?/i? iieacieee o oai?eo ia a??oniee aaiaoeo A // ? - e iaoe?iiaeueiee eiia?an Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe??. Ca??ea oac. - Aeoooa. - 1998. - N.164 - 165. 8. I?e?oi?iaa O.I., Aeeeee A.I., Eia?ei O.C., A?eaeae ?.A., I?eoeye I.ss., Ith?ee A.O., Eiciaee A.I. Ee?i?ei - eaai?aoi?i? oa ?ino?oiaioaeuei? iaoiaee ianoaaeaiiy a aeeoa?aioe?aeuei?e ae?aaiinoeoe? aeiaoyieoeue // ?ioaeoe?ei? oai?iae (?acoeueoaoe iaoeiai - aeine?aeii? ?iaioe, aeena?oaoe?eieo aeine?aeaeaiue). Aeione VI. - Euea?a, 1999. - N. 8 - 9. AIIOAOe?ss A?eaeae ?.A. Canoinoaaiiy e?o?th ea?aiiaoo a eiiieaeniiio e?eoaaii? oai?eo ia aino?? aaiaoeoe A ? A. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.13 - ?ioaeoe?ei? oai?iae. Iaoeiai-aeine?aeiee ?inoeooo ai?aeai?ieia?? oa ?ioaeoe?eieo oai?ia ?i. E.A. A?iiaoaanueeiai IIC Oe?a?ie, Ee?a, 1999. A ?iaio? iiaeaii ?acoeueoaoe ee?i?ei-a?io?i?/ieo, ?ioiieia?/ieo ? oeeoiaaiaoe/ieo aeine?aeaeaiue oai?eo ia aino?? aaiaoeoe A ? A ?c ??cieie oi?iaie aaaeeino? oa ioe?ieo aoaeoeaiino? eiiieaeniiai e?eoaaiiy ?c canoinoaaiiyi e?o?th ea?aiiaoo - i?aia?aoo, yeee aieiae?? ii?iioei?/ieie oa ?ioiio?iiieie aeanoeainoyie, a ii??aiyii? ?c caaaeueiii?eeiyoith aaceniith oa?ai??th. Eiiieaenia e?eoaaiiy ?c e?o??i ea?aiiaoii oai?eo ia aino?ee aaiaoeo A i?eaiaeeoue aei ca?eueoaiiy e?eueeino? aaeeeeo a?aioey?ieo e?ioioeeo?a a ia?eoa?e/i?e e?ia? oa cieaeaiiy ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a, iie?auaiiy iieaciee?a oaaioeeoico ? ooieoe?iiaeueiiai noaio aaiioeio niiaoe/ieo ee?oei, ciaioaiiy i?iya?a anoaiiaaaaoaoeaiiai neiae?iio, aea ia aieeaa? ia o?eaae?noue aeiaoyie/iiai ia??iaeo. Anoaiiaeaii, ui canoinoaaiiy e?o?th ea?aiiaoo a eiiieaeniiio e?eoaaii? oai?eo ia aino?ee aaiaoeo A ?c na?aaeiueiaaaeeith oi?iith oa oai?eo, ye? io?eioaaee i?aaei?cieii, aea? ae?aaeaiee ee?i?/iee aoaeo, oaeaeoa ii?iae?cothoueny iieacieee a?e??oa?iiaiai iai?io ? nei?i/o?oueny aeiaoyie/iee ia??iae. O iaoe??io?a a?aeiiaeth?oueny ?ioiieia?/iee noaoon i?aai?cio, caa??aa?oueny aaeain i?ae niaoeeo?/ieie oa ianiaoeeo?/ieie /eiieeaie ee?oeiiiai ?ioi?oaoo, iie?auo?oueny oaaioeeoa?ia aeoeai?noue iaeo?io?eueieo a?aioeioeeo?a ? ooieoe?iiaeueiee noai aaiioeio niiaoe/ieo ee?oei, ye? ia?aaoaathoue a ?ioa?oac?. Eeth/ia? neiaa: a??oni? aaiaoeoe, ?ioi?oao, oaaioeeoic, ooieoe?iiaeueiee noai aaiioeio, e?o?th ea?aiiao, e?eoaaiiy. AIIIOAOeEss A?eaeae E.E. Eniieueciaaiea eeoey ea?aiiaoa a eiiieaeniii ea/aiee aieueiuo ino?uie aaiaoeoaie A e A. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.13 - eioaeoeeiiiua aieacie. Iao/ii-enneaaeiaaoaeueneee einoeooo yieaeaieieiaee e eioaeoeeiiiuo aieaciae ei. E.A. A?iiaoaaneiai IC Oe?aeiu, Eeaa, 1999. A aeenna?oaoeee i?aaenoaaeaiu ?acoeueoaou eeeieei-aeioeie/aneeo, eiioiieiae/aneeo e oeeoiaaiaoe/aneeo enneaaeiaaiee aieueiuo ino?uie aaiaoeoaie A e A ?acee/iuo oi?i oyaeanoe e ioeaiea yooaeoeaiinoe eiiieaeniiai ea/aiey n eniieueciaaieai eeoey ea?aiiaoa - i?aia?aoa n ii?iioeie/aneeie e eiioiio?iiiuie naienoaaie a n?aaiaiee n iauai?eiyoie aaceniie oa?aieae. Eeoee ea?aiiao iacia/aeny ii 0,6 a nooee aioo?ue ( a aeaa i?eaia) ni 2-3-ai aeiy noaoeeiia?iiai ea/aiey ia i?ioyaeaiee 10 aeiae. Aieueiui n i?aaeaanieeaie yioeaoaeiiaoee, a ea/aiee eioi?uo aue i?eiaiai i?aaeiecieii, i?aia?ao iacia/aee a aeica 0,9 a nooee ( a o?e i?eaia ) a iineaaeiea 10 aeiae eo?na i?aaeiecieiia. O aieueiuo ino?uie ae?oniuie aaiaoeoaie iaaethaeaaony ia?ooaiea eeaoi/iiai eiioiiiai noaoona. I?e aaiaoeoa A oiaiueoaaony ioe O-oaioeeeei/oanoaeoaeueiuo eeaoie e oaaee/eaaaony ioe aieueoeo a?aioey?iuo eeioioeeoia. I?e aaiaoeoa A anoue O-eeioiiaiey ca n/ao O-oaioeeeei/oanoaeoaeueiuo eeaoie, oiaiueoaiea eiee/anoaa aieueoeo a?aioey?iuo eeioioeeoia e oaaee/aiea /enea 0-eeioioeeoia. Iniaaiiinoyie aaiaoeoa A, i?ioaeaaoaai n ia?aaeaanieeaie yioeaoaeiiaoee, auei nieaeaiea ioea O- aeoeaiuo eeaoie e oaaee/aiea A-eeoioeeoia. O?iaie oee?eoee?othueo eiioiiuo eiiieaenia e eiioiiaeiaoeeiia I aic?anoaee i?e aaiaoeoao A e A a niioaaonaee n oi?iie oyaeanoe. Eiee/anoai iaeo?ioeeueiuo a?aioeioeeoia oiaiueoaeinue e ia?ooaeanue eo oaaioeeoa?iay aeoeaiinoue, /oi auei i?e/eiie aaeoa?eaeueiuo ineiaeiaiee. O aieueiuo n i?aaeaanieeaie yioeaoaeiiaoee iaaethaeaeny iaeo?ioeeac ni cia/eoaeueiui ia?ooaieai niiniaiinoe a?aioeioeeoia e oaaioeeoe?iaaieth iee?iaiuo eeaoie. Iaeaieaa /anoi aaeoa?eaeueiua ineiaeiaiey eiaee ianoi eiaiii a yoie a?oiia iaoeeaioia ( 81,8%). O iaoeeaioia ni n?aaeiaoyaeaeie oi?iie aaiaoeoa A e oaeaea aaiaoeoa A eco/aii ooieoeeiiaeueiia ninoiyiea niiaoe/aneeo eeaoie (eeaoee aoeeaeueiiai yieoaeey), i?aauaathueo a eioa?oaca, e onoaiiaeaii cia/eoaeueiia aai nieaeaiea ca n/ao oaaee/aiey /enea eeaoie niaea?aeaueo iaoieiae/anee eciaiaiiua yae?a, a oaeaea yae?a niaea?aeauea iieiaie o?iiaoei. A niioaaonoaee n oyaeanoueth aaiaoeoa a nuai?ioea e?iae oaaee/eaaeny o?iaaiue eiia eeoey, /oi auei neaaenoaeai oeeoieeoe/aneiai neiae?iia. Onoaiiaeaii, /oi o aieueiuo aaiaoeoii A iiae aeeyieai ea/aiey n eniieueciaaieai eeoey ea?aiiaoa, ii n?aaiaieth n aaceniie oa?aieae, aic?anoaao eiee/anoai aieueoeo a?aioey?iuo eeioioeeoia e nieaeaaony o?iaaiue oee?eoee?othueo eiioiiuo eiiieaenia, oeo/oaaony ooieoeeiiaeueiia ninoiyiea aaiioeia niiaoe/aneeo eeaoie, auno?aa ono?aiyaony anoaiiaaaaoaoeaiue neiae?ii, ii nie?auaiey aeaeoooiiai ia?eiaea ia ianooiaao. Eiiieaeniia ea/aiea aaiaoeoa A n eniieueciaaieai eeoey ea?aiiaoa, ii n?aaiaieth n yooaeoeaiinoueth aaceniie oa?aiee, eiaao nouanoaaiiua i?aeiouanoaa: auno?aa ii?iaeece?othony iieacaoaee aeee?oaeiiaiai iaiaia, nieaeaaony o?iaaiue AnAO e nie?auaaony aeaeoooiue ia?eiae o aieueiuo ni n?aaeiaoyaeaeie oi?iie. O anao aieueiuo ainnoaiaaeeaaaony eiioiieiae/aneee noaoon: aic?anoaao eiee/anoai iaueo O-eeaoie, oaioeeei/oanaeoaeueiuo e aieueoeo a?aioey?iuo eeioioeeoia, o.a. nio?aiyaony aaeain iaaeaeo niaoeeoe/aneeie e ianiaoeeoe/aneeie oaeoi?aie eeaoi/iiai eiioieoaoa, nieaeaaony o?iaaiue oee?eoee?othueo eiioiiuo eiiieaenia; aic?anoaao aaniethoiia eiee/anoai iaeo?ioeeia a ia?eoa?e/aneie e?iae, ainnoaiaaeeaaaony eo oaaioeeoa?iay aeoeaiinoue e aeoeaiinoue oa?iaioa ieaeiia?ieneaeacu. Iiae aeeyieai i?aia?aoa oeo/oaaony ooieoeeiiaeueiia ninoiyiea aaiioeia niiaoe/aneeo eeaoie ca n/ao oiaioaiey eiee/anoaa eeaoie niaea?aeaueo aaoa?iieeiioe/aneoth O-o?iiiniio e eeaoie n iaoieiae/anee eciaiaiiuie yae?aie. Oeacaiiue niinia ea/aiey auno?aa ono?aiyao i?iyaeaiey anoaii-aaaaoaoeaiiai neiae?iia, cia/eoaeueii oiaiueoaao /anoioo niioonoaothueo aaeoa?eaeueiuo ineiaeiaiee, oeo/oaao ea/anoai iaaeeeaiaioiciie ?aaaeeeoaoeee iaoeeaioia. O aieueiuo, i?eiathueo i?aaeiecieii, aaeoa?eaeueiua ineiaeiaiey ia oiia oiio?aaeaiey eeoey ea?aiiaoa aicieeaee cia/eoaeueii ?aaea ( 41,7 % ). Ii o aieueiuo n oyaeaeie oi?iie aaiaoeoa A i?aia?ao ia ieacuaaao iieiaeeoaeueiiai aeeyiey ia eeeie/aneia oa/aiea aieacie. Iinea 10-oe aeiaaiiai oiio?aaeaiey eeoey ea?aiiaoa a aeica 0,6 a nooee o aieueiuo n aaiaoeoaie A e A eiioeaio?aoeey eeoey a nuai?ioea e?iae ninoaaeyea a n?aaeiai 0,295 0,017 iiieue/e. O aieueiuo n i?aaeaanieeaie yioeaoaeiiaoee, eioi?ui iacia/aeny eeoey ea?aiiao ii 0,9 a nooee ia i?ioyaeaiiee 10 aeiae, eiioeaio?aoeey eiia aeinoeaea o?iaiy - 0,4810,036 iiieue/e. Neioiiia eioieneeaoeee ia iaaethaeaeinue. Eeth/aaua neiaa: ae?oniua aaiaoeou, eiioieoao, oaaioeeoic, ooieoeeiiaeueiia ninoiyiea aaiioeia, eeoey ea?aiiao, ea/aiea. ANNOTANION Grizhak I.H. Application of Lithium Carbonatis in a Complex Treatment of patients with Hepatites A and B. - Manuscript. A thesis to obtain the scientific degree a candidate of sciense ( medicine ) in speciality 14.01.13 - Infections Diseases. The Gromashevsky Epidemiology and Infections Diseases Research Institute under Ukranian Ministry of Health, Kyiv, 1999. The work presents rezults of clinicobiochemical, immunologic and citogenetic study of patients suffering from acute hepatites A and B with differrent levels of severity and conteins an estimation of the efficiency using a preparation with normothymic and immunotropic features - lithium carbonatis compared with a routine basic therapy. The complex treatment with lithium carbonatis of the acute hepatitis A patients result in an increase of the large granular lymphocytes number and the a decrease in the circulating immune complexes level, an improvement of the phagocytosis indices and functional status of the somatic cells genotypes, reductions of asthenic vegetativ syndrom manifestations, but doesn’t reduce the jondice period. It was found out that lithium carbonatis use in a complex treatment of patients suffering from acute hepatitis B with a middle severity and patients who had received prednisolone gave a pronounced effect, bilirubin exchange findings get normalized sooner and jaundice period reduces. The patients restore the organism immunologic status, a balance between specific and nonspecific factors of the cellular immunity is maintained, the phagocytic activity of neutrophils granulocytes increase and the genotype functional status of the somatic cells being in an interphase improves. Key Words: virus hepatites, immunity, phagocytosis, genotype functional status, lithium carbonatis, treatment.

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