Застосування електричного поля постійного струму в комплексному лікуванні гнійних холангітів та холестатичної печінкової недостатності в ранньому післ

15

I?I?NOA?NOAI IOI?IIE CAeI?IAss OE?A?IE

OA?III?EUeNUeEA AeA?AEAAIA IAAeE*IA AEAAeAI?ss

?i. ?.ss.Ai?aa/aanueeiai

A?AAAITHE Aieiaeeie? ?aaiiae/

OAeE 616.36-06;616.366-003.7]-085.844.1

Canoinoaaiiy aeaeo?e/iiai iiey iino?eiiai no?oio a eiiieaeniiio
e?eoaaii? ai?eieo oieaia?o?a oa oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino?
a ?aiiueiio i?neyiia?aoe?eiiio ia??iae?

(aenia?eiaioaeueii-eeiii/ia aeineiaeaeaiiy)

14.01.03 — oi?o?aiy

Aaoi?aoa?ao aeena?oaoei?

ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?iii?eue — 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Aoeiaeinuee?e aea?aeaai?e iaaee/i?e aeaaeai?? IIC
Oe?a?ie

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe ?ooiae?e Aiae??yi Aai?a?eiae/,
aeioeaio eaoaae?e oieoaeueii? o??o?a?? AAeIA

Io?oe?ei? iiiiaioe:

Aeieoi? iaaee/ieo iaoe, i?ioani? Ie/eoaeei Ieoaeei THoeiiae/, ?inoeooo
ee?i?/ii? ? aenia?eiaioaeueii? o??o?a?? AII Oe?a?ie, caa?aeoaa/
a?aeae?eii ia/?iee ? aeia/ieo oeyo?a.

Aeieoi? iaaee/ieo iaoe, i?ioani? Aiae?thuaiei A?eoi? Iao?iae/,
Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie, i?ioani?
eaoaae?e oaeoeueoaonueei? ? caaaeueii? o??o?a?? c eo?nii i?ieoieia??.

I?ia?aeia onoaiiaa:

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC
Oe?a?ie, eaoaae?a o??o?a??.

Caoeno a?aeaoaeaoueny “8” aeiaoiy 1999 ?. i 1200 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 58.601.01 o Oa?iii?euenuee?e iaaee/i?e
aeaaeai?? ?i. ?.ss.Ai?aa/aanueeiai.

Aae?ana aeaaeai??: 282001, Oa?iii?eue, iaeaeai Aie?, 1

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? aeaaeai?? ca
aae?anith: i.Oa?iii?eue, aoe. ?onueea, 12.

Aaoi?aoa?ao ?ic?neaiee “6” aa?aniy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee E 58.601.01

aeieoi? iaaee/ieo iaoe, i?ioani? E?o I.I.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeuei?noue oaie. Eieoaaiiy oneeaaeiaieo oi?i aeia/ieai’yii? oai?iae
i?iaeiaaeo? caeeoaoenue aeooaeueiith i?iaeaiith [Magnuson T.H. et al.,
1997]. Iniiaiei iaoiaeii eieoaaiiy iaoaii/ii? aeiaoyieoei caeeoa?oueny
oi?o?ai/iee, i?e oeueiio aeiooaia oi?o?ai/ia aeoeaiinoue o oai?eo c
aenieei nooiaiai iia?aoeieiiai ?eceeo nyaa? 64,3 — 70% [Aiae?thuaiei
A.I., 1998; Kajyama G., 1997], a eieuee?noue oneeaaeiaiue a
iineyiia?aoeieiiio ia?iiaei c?inoa? aei 19,6% [Iai/e/ A.?., 1995;
Caeoeaa A.O., 1995], iniaeeai o aeaeyaei aino?i? ia/?ieiai?
iaaeinoaoiino? (21,2%). Aeciaiiy ?iei iioaeoei? i?e aieia?i?e
iano?oeoei?, ye iniiaii? i?e/eie ?icaeoeo aiieieo oieaiaioia, noaei
i?eaiaeii aeey oe?ieiai aeei?enoaiiy aioeiie?iaieo i?aia?aoia [Naaiei
A.O., Ie/eoaeei I.A., 1996; Demolis J.L. et al., 1996; Finkelstein R. et
al., 1996]. I?ioa a?eueo?noue c ieo iathoue ae?aaeaio aaiaoioiene/io
aeith [Actis G.C. et al., 1995; Sung J.J. et al., 1995], ui ?iaeoue ?o
aeei?enoaiiy iaiiaeeeaei i?e ?icaeoeo aino?i? ia/?ieiai? iaaeinoaoiino?.
Ia oiii oieanoaco ia aaea?oueny aeinyaoe oa?aiaaoe/ii aoaeoeaii?
eiioeaio?aoei? aioeaaeoa?iaeueieo i?aia?aoia o aeia/i aianeiaeie
ii?ooaiiy nae?aoi?ii? ooieoei? ia/iiee.

A aieueoino? ?iaio, i?enay/aieo ?acoeueoaoai eieoaaiiy oai?eo ia
aeia/ieai’yio oai?iao, oneeaaeiaio iaoaii/iith aeiaoyieoeath, iniiaiith
i?e/eiith nia?oi iiney oeeo iia?aoeie aaaaea?oueny ia/?ieiaa
iaaeinoaoi?noue [He/eoaeei I.A., 1995, 1998; Nakai T., 1996;
Aiae?thuaiei A.I., 1998], yea cono?i/a?oueny i?e aino?iio oieaoeenoeoi o
4,2 — 21,2% i ?? /anoioa c?inoa? ci caieueoaiiyi aieo iaoei?ioia oa
o?eaaeinoth iaoo?aoeieii? aeiaoyieoei. Ai?eiee oieaia?o caaaeaee
noi?iaiaeaeo?oueny i?eaii/aiiyi ooieoeiiiaeueiiai noaio ia/iiee, ui
i?iyaey?oueny o aeaeyae? ia/?ieiai? iaaeinoaoiino? [Eiaaeue/oe E.ss. oa
?i., 1998; Iaeneiethe A.?., 1998; Csendes A. et al., 1996].
Eaoaeueiinoue i?e ?icaeoeo ia/?ieiai? iaaeinoaoiino? a no?oeoo?i i?e/ei
nia?oi i?e aino?ie iaoieiai? iicaia/iieiaeo aeia/ieo oeyoia iin?aea?
ia?oa iinoea [Eiaaeue/oe E.ss. oa ?i., 1994; Na?iei A.O., 1996], ui a
caaaeueiiio neeaaea? 3,14-3,6%.

Aiaeic aeaea?ae iioi?iaoei? oa aeanieo niinoa?aaeaiue na?ae/eoue i?i
aeioeieueiinoue ?ic?iaee i?inoeo oa aeinooiieo iaoiaeia e?eoaaiiy
ai?eieo oieaia?o?a oa ia/?ieiai? iaaeinoaoiino? a ?aiiueiio
iineyiia?aoeieiiio ia?iiaei, ui aacothoueny ia ii?aeiaiii aei?
aeaeo?e/iiai iiey iinoieiiai no?oio oa iaaeeeaiaioicii? oa?aii?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?? caoaa?aeaeaia A/aiith ?aaeith Aoeiaeinueei? aea?aeaaii?
iaaee/ii? aeaaeai?? IIC Oe?a?ie (i?ioieie ? 13 a?ae 26.12.1996 ?.) ? ?
o?aaiaioii ieaiiai? iaoeiai? ?iaioe eaoaae?e oieoaeueii? oi?o?ai?
Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeaii? (? aea?ae?a?no?aoei?
01.93V027781 (1993-1997 ??.).

Iaoa ?iaioe. Iiaeaeueoe aoaeoeai?noue eieoaaiiy oai?eo ia aino?ee
ai?eiee oieaia?o oa oieanoaoe/io ia/?ieiao iaaeinoaoi?noue i?e
aeia/ieai’yiie oai?iai a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? ca
aeiiiiiaith aeei?enoaiiy aeaeo?e/iiai iiey iino?eiiai no?oio.

Aeey aeinyaiaiiy aeaii? iaoe aoee iinoaaeai? ianooii? caaea/?:

1. Iaa?oiooaaoe aoaeoeaiinoue canoinoaaiiy aeaeo?e/iiai iiey iinoieiiai
no?oio ?icii? aonoeie a eieoaaiii aino?eo ai?eieo oieaia?o?a oa
oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino? i?e aeia/ieai’yiie oai?iai.

2. Aea/eoe ciiie o?ceei-o?i?/ieo iieaciee?a aeia/i a aenia?eiaio? oa
ee?i?oe? iiae aieeaii aeaeo?e/iiai iiey iino?eiiai no?oio.

3. Aea/eoe aeeiaiieo iie?iaii? eiioai?iaoe?? aeia/i a i?ioeani
aenia?eiaioo iiae aieeaii aeaeo?e/iiai iiey iino?eiiai no?oio.

4. ?ic?iaeoe oa ai?iaaaeeoe a eieoaaeueio i?aeoeeo iiai iaoiaaiaoe/ii
iaa?oioiaaii iaoiaee eieoaaiiy aino?eo ai?eieo oieaia?o?a oa
oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino? i?e aeia/ieai’yiie oai?iai.

5. I?iaanoe ii?iaiyeueio ioe?ieo aoaeoeaiino? cai?iiiiiaaii? iaoiaeeee c
caaaeueiii?eeiyoeie iaoiaeaie eiiieaeniiai eieoaaiiy oai?eo ia aino?ee
ai?eiee oieaia?o oa oieanoaoe/io ia/?ieiao iaaeinoaoi?noue a ?aiiueiio
iineyiia?aoeieiiio ia?iiaei.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoaoia.

Aaoi?ii aia?oa a aenia?eiaioaeueieo oiiaao c’yniaaii iioeiaeueii
ia?aiao?e oa o?eaaeinoue naainia aieeao aeaeo?e/iiai iiey iino?eiiai
no?oio (AIIN) ia aiaieua o?aaeaiiy. Iioeiaeueiee aoaeo aei? AIIN a
eiiieaeniiio eieoaaiii aino?eo ai?eieo oieaia?o?a aeyaey?oueny i?e
aonoeii aeaeo?e/iiai iiey a aeia/? aiae 1,5 aei 2,8 iA/ni2 oa o?eaaeinoi
naain?a 60 oaeeei; i?e ia/?ieia?e iaaeinoaoiino? iioeiaeueiith ? ae?y
AIIN aonoeiith a aeia/? 0,7-1,4 iA/ni2, ui i?ecaiaeeoue aei aiaeiiaeaiiy
eeioeiiiai aiiainoaco aaiaoioeeoia i, oaeei /eiii, ii?iaeicaoei?
nae?aoi?ii? ooieoei? ia/iiee.

Aeyaeaii aaeoa?eoeeaeiee aoaeo aieeao aeaeo?e/iiai iiey iino?eiiai
no?oio ia iaoiaaii? oa oiiaii iaoiaaii? i?e?ii?aai?cie – caoaeieeia
oieaiaioo i?e aeia/ieai’yiie oai?iai a ?aiiueiio iineyiia?aoeieiiio
ia?iiaei.

Aeyaeaii caeaaei?noue ciiie /ooeeainoi caoaeieeia oieaia?oo aei
aioeiie?iaieo caniaia a aeia/? aiae neee no?oio.

Aeiaaaeaii aeicicaeaaeiee aoaeo noeioethth/i? ae?? AIIN ??cii? aonoeie
ia nae?aoi?io ooieoe?th ia/?iee i?e aino?eo ai?eieo oieaia?oao oa
oieanoaoe/i?e ia/?ieia?e iaaeinoaoiino?. Iaea?eueo iioeiaeueiei ? aieea
AIIN aonoeiith a aeia/? 0,7-1,4 iA/ni2 i?e ?io?aoieaaeioaaeueiiio
?icoaooaaii? aeoeaiiai aeaeo?iaeo.

Aeyaeaii aoaeo ii?iae?caoe?? oiceei-oiii/ieo ia?aiao?ia aeia/i iiae
aieeaii AIIN. I?e oeueiio cyniaaii, ui iaea?eueo iioeiaeueieie
ia?aiao?aie ? aonoeia no?oio a aeia/? aiae 1,5 aei 2,8 iA/ni2 i?e
aino?iio oieaia?o? oa 0,7-1,4 iA/ni2 – i?e ia/?ieia?e iaaeinoaoiino?.

Ia iniia? aenia?eiaioaeueieo aeine?aeaeaiue ?ic?iaeaii oa ai?iaaaeaeaii
a i?aeoeeo iiai iaoiaee eiiieaeniiai eieoaaiiy aino?eo ai?eieo
oieaia?o?a oa ia/?ieiai? iaaeinoaoiino? a ?aiiueiio iineyiia?aoeieiiio
ia?iiaei, ui aacothoueny ia ii?aeiaiiio canoinoaaii? aeaeo?e/iiai iiey
iino?eiiai no?oio oa iaoiaaiaoe/ii iaa?oioiaaieo e?ea?nueeeo cania?a.

?ic?iaeaii iiaee niin?a iiaeaethaaiiy aino?iai aenia?eiaioaeueiiai
oieaoeenoeoo (Aea?aeiaoaio 23140A Oe?a?ia, G09A23/28, A61A10/00 a?ae
30.06.98).

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoaoia.

Pic?iaeaii oa ai?iaaaeaeaii a oi?o?ai/io i?aeoeeo iiai iaoiaee
eieoaaiiy oai?eo ia aino?ee ai?eiee oieaia?o oa oieanoaoe/io ia/?ieiao
iaaeinoaoi?noue a ?aiiueiio iineyiia?aoeieiiio ia?iiaei.

C o?aooaaiiyi iniaeeainoae ia?aa?ao aino?iai oieaia?oo oa oieanoaoe/ii?
ia/?ieiai? iaaeinoaoiino? a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? iaie
?ic?iaeai? ?iciiiai?oii aa??aioe aioo??oiueioeaieiiiai aeaeo?ioi?aco
iaoiaaiaoe/ii iaa?oioiaaieo e?ea?nueeeo cania?a, ui aeathoue
iiaeeea?noue aeinyaoe iaeneiaeueii? oa?aiaaoe/ii? aei? a ciii o?aaeaiiy.

?ic?iaeaii oa ai?iaaaeaeaii a o??o?a?/io i?aeoeeo niin?a ?aa?iia?ii?
aioea?ioeeioa?ai?? caiaeueieo caoai?thaaiue a?e?a?ii? nenoaie (Iiceo.
??oaiiy i?i aeaea/o Iaoaioo Oe?a?ie ia aeiao?ae a?ae 01.12.98 ?. ca
cayaeith ? 97073445) oa niin?a e?eoaaiiy caiaeueieo caoai?thaaiue
aeia/iiai i?oo?a oa iicaia/?ieiaeo aeia/ieo i?ioie?a (Iiceo. ??oaiiy i?i
aeaea/o Iaoaioo Oe?a?ie ia aeiao?ae a?ae 01.12.98 ?. ca cayaeith ?
97073446).

Ai?iaaaeaeaiiy a i?aeoeeo iaaaaeaieo iaoiaeia a oi?o?ai/iiio
aiaeaeieaiii ? 1 iinueei? eeiii/ii? eiea?ii ? 1 i.*a?iiaoei iieacaei
?oith aenieo eieoaaeueio aoaeoeaiinoue oa aeicaieeei ciaioeoe
e?aeei-aeaiue i?e oieaia?oao c 22,641,61 aei 16,881,31 (p<0,01), cieceoe e?euee?noue i?neyiia?aoe?eieo ai?eii-naioe/ieo oneeaaeiaiue ia 9,6%, ciaioeoe eaoaeueiinoue aiae ia/?ieiai? iaaeinoaoiino?, iie?aueoe ?acoeueoaoe eieoaaiiy aeaii? eaoaai?i? oai?eo. Iniaenoee aianie caeiaoaa/a. Aaoi? cae?eniea ?ic?iaeo iniiaieo oai?aoe/ieo ? i?aeoe/ieo iieiaeaiue ?iaioe, a naia: - aea/ea caeiiiii?iinoi ciii i?e?iaii? eiioai?iaoe?? o aeia/i iiae aieeaii aeaeo?e/iiai iiey iinoieiiai no?oio i?e oieaia?oao oa oieanoaoe/i?e ia/?ieia?e iaaeinoaoiino?; - aenia?eiaioaeueii aea/ea aeeiai?eo ciii oiceei-oiii/ieo ia?aiao?ia aeia/i iiae aieeaii AIIN; - ?ic?iaea niinia eieoaaiiy ai?eieo oieaia?o?a oa oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino? o oai?eo ia aeia/ieai'yio oai?iao a ?aiiueiio iineyiia?aoeieiiio ia?iiaei; - ca o/anoth aeena?oaioa i?ie?eiaaii 72% oai?eo; - aaoi?ii i?iaaaeaii aiae?c oa ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy, noi?ioeueiaaii on? iieiaeaiiy, aeniiaee oa ai?iaaaeaeaii a i?aeoeeo iaoiaee/i? ?aeiiaiaeaoe??. Ai?iaaoeiy ?acoeueoaoia aeena?oaoei?. Iniiai? iieiaeaiiy aeena?oaoe?? aeeeaaeai? oa iaaiai?ai? ia iaoeiai-i?aeoe/ieo eiioa?aioeiyo Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeaii? (*a?iiaoei, 1996, 1997, 1998), iiaeia?iaeiie iaoeiaie eiioa?aioei? "Aeooaeueii ieoaiiy no/anii? oi?o?ai?" (Oaeai?iae, 1997 ?.), ia?oiio iiaeia?iaeiiio eiia?ani anioeiaoei? oi?o?aia Poioii? "Oi?o?aiy ia ii?ici o?aoueiai oeny/ieiooy" (Piatra Neamt, Poioiiy, 1997 ?.), 2-io iiaeia?iaeiiio iaaee/iiio eiia?ani nooaeaioia i iieiaeeo a/aieo (Oa?iiiieue, 1998 ?., aea ?iaioa ca aeooaeuei?noth ieoaiiy oa ?acoeueoaoaie aeine?aeaeaiue iin?ea 1-oa i?noea), 4-iio i?aeia?iaeiiio iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo (Katowice, Iieueua, 1998 ?.), ia ?? Eiia?an? o??o?a?a Oe?a?ie (Aeiiaoeuee, 1998 ?.), ni?eueiiio can?aeaii? eaoaae? oieoaeueii?, oaeoeueoaonueei?, caaaeueii? o??o?a?e, iaoeiai? eii?n?? Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeai?? oa oiaa?enoaa o??o?a?a *a?i?aaoeueei? iaeano? 23 a?oaeiy 1998 ?ieo. Ioaeieaoei?. Iniiaii iieiaeaiiy aeena?oaoei? aeeeaaeaii a 12 ae?oeiaaieo i?aoeyo, o o./. a 2 oaoiaeo iaoeiaeo aeaeaiiyo, io?eiaii iaeei iaoaio Oe?a?ie ia aeiao?ae oa aeaa iiceoeaieo ??oaiiy i?i aeaea/o iaoaioo Oe?a?ie ia aeiao?ae, aeaeaii iaoiaee/i? ?aeiiaiaeaoei? "Eiiieaenia i?ioieaeoeea oa eieoaaiiy iineyiia?aoeieieo oneeaaeiaiue aiieii-naioe/iiai oa?aeoa?o c aeei?enoaiiyi iinoieiiai no?oio a oi?o?ai?" (*a?iiaoei, 1996). No?oeoo?a i ianya aeena?oaoei?. Iaoa?iae aeena?oaoeieii? ?iaioe aeeeaaeaii ia 142 noi?iieao iaoeiiieno. Aeena?oaoeiy neeaaea?oueny c 6 /anoei, yei aeeth/athoue anooi, 4 ?icaeiee, aiae?c oa ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy, aeniiaee, i?aeoe/ii ?aeiiaiaeaoei?, nienie aeei?enoaieo aeaea?ae. Oaeno iethno?iaaiee 40 oaaeeoeyie, 14 iaethieaie. Nienie eioa?aoo?e iinoeoue 265 iaeiaioaaiue, c ieo 100 iiicaiii. Iniiaiee ci?no ?iaioe Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeineiaeaeaiiy ii aea/aiith aieeao AIIN ia ia?aaia aino?iai ai?eiiai oieaia?oo (AAO) oa ia/?ieiai? iaaeinoaoiino? (II) i?e iaoaii/iie aeiaoyieoei i?iaaaeaii ia 69 oaa?eiao (aacii?iaeieo niaaeao) ?icii? noaoi, aaaith 16-24 ea, a iia?aoe?eieo a?aa??th Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeai??. Aiaeoai?aiiy aenia?eiaioaeueii? iiaeaei AAO i?iaaaeaii ca ?ic?iaeaiei iaie niiniaii iiaeaethaaiiy aino?iai aenia?eiaioaeueiiai oieaoeenoeoo (iaoaio 23140 A Oe?a?ie, IIE G09B23/28, A61B10/00 a?ae 30.06.98 ?.) ia 28 oaa?eiao. Aieea AIIN ia aeieyieo ia/iiee i?e ?iciie aonoeii no?oio i?iaiaeeee ia i?ioyci 60 oaeeei uiaeaiii. A 1-e a?oii oaa?ei (8) iiaeeeth/aee iaoei?ii ?icoaoiaaii aeaeo?iaee aei ?icieo iiethnia aia?aoo "Iioie-1". A 2-e a?oii (8) noa?eeueiee aeaeo?iae aaiaeeee a ae?aiaae caaaeueii? aeia/ii? i?ioiee, uia aii ia aeioiaeea ia 1-2 ni aei ioai?ia ae?aiaaeii? o?oaee, oa iiaeeeth/aee aei iiceoeaiiai eiioaeoo. Aieaoa?aeueiee iaoei?iee aeaeo?iae iiaeeeth/aee aei eeaie "iiion". A 3-e a?oii oaa?ei (8) iiceoeaiee aeaeo?iae aaiaeeee aiaeia?/ii 2-e, aiae'?iiee - a ae?aiaae iiaeia/iieiaiai i?inoi?o iiney iiia?aaeiueiai caiiaiaiiy eiai 10 ie 0,5% ?ic/eio aeiieneaeeio. Aeey eiio?ieth aeei?enoaee 4 niaae. Aeey ioe?iee aoaeoo aei? AIIN, a oiaei o?iii/iiai aenia?eiaioo, iaie aecia/aeeny iieacieee ?I oa ieoiiiai aeaeo?e/iiai iii?o aeia/i (IAI). Aeeiaii/ia aea/aiiy ciiie ?aaeoei? aeia/i i?iaiaeeeinue ca aeiiiiiaith aia?aoo EEAE-1 Eai'yiaoeue-Iiaeieuenueeiai NEA IAO. *a?ac ae?aiaae caaaeueii? aeia/ii? i?ioiee aaiaeeee iie?iciiae aeii?thaaiiy ia aeeaeio 10 ni, aeaeo?iae ii?iaiyiiy oienoaaany ia iiia?aaeiuei aeaieaiiio aoni niaaee. Iieacieee ?a?no?oaaeenue ia oeeo?iaiio oaaei i?eeaaeo. Aeey aecia/aiiy IAI oi?eoeai c ae?aiaaeo caaaeueii? aeia/ii? i?ioiee caae?aany 1 ie aeia/i. IAI aecia/aee ca iaoiaeeeith, iienaiith I.N.Ei/iaaei oa niiaaao. [1992]. Aenia?eiaioaeueio ea?oeio iaoo?aoeieii? aeiaoyieoei c ?icaeoeii II oa AAO a?aeoai?thaaee ca iaoiaeeeith I.O. Hanoa?eia oa P.A.Ha?iaeaoeeie ia 41 niaaoe?. Aieea AIIN i?iaiaeeany i?ioyaii 60 oaeeei uiaeaiii. Niaaee aoee iiae?eai? ia 4 a?oie. Aei eiio?ieueii? a?oie oa?eoee 4 niaaee, aei 1-i? a?oie (c iaoe??iei ?icoaooaaiiyi aeaeo?iae?a) – 12 niaae, 2-i? (c aeaeo?iaeii a i?ina?o? caaaeueii? aeia/ii? i?ioiee) – 12, oa 3-i? (iaeei aeaeo?iae a caaaeuei?e aeia/i?e i?ioioe?, ?ioee – a i?ina?o? ae?aiaaeo i?aeia/?ieiaiai i?inoi?o) - 13 niaae. Aea/aii aieea AIIN ??cii? neee ia aeeoo?caeaoi?noue iaoiaaiieo oa oiiaii iaoiaaiieo iie?ii?aaiiciia, aeae?eaieo c aeia/?. Aeey i?e?ia?ieia?/ieo aeine?aeaeaiue i?iaiaeeany caa?? 1 ie aeia/? c ae?aiaaeo caaaeueii? aeia/ii? i?ioiee a noa?eeuei? i?ia??ee aaciina?aaeiuei ia?aae naainaie aaeueaai?caoe??, iae?aco i?ney naaino, /a?ac 2, 4, 6 oa 10 aiaeei i?ioyaii 6 ae?a. Iin?ae i?iaiaeeeenue ia oaa?ae? na?aaeiaeua c aeiaeaaaiiyi aeia/? oa aecia/aiiyi /ooeeaino? io?eiaieo caoaeiee?a aei aioea?ioee?a. Eoeueoo?e i?e?ii?aai?ci?a ae?iuoaaee i?ioyaii 24 aiaeei i?e oaiia?aoo?? 37N, i?ney /iai ?aeaioeo?eoaaee aeae caoaeieea. E?euee?noue aeeoo?caeaoieo ee?oei ae?aoiaoaaee a aeanyoe/ieo eiaa?eoiao. *ooeea?noue i?e?ii?aai?ci?a aei aioea?ioee?a aecia/aee ia niaoe?aeueiiio "o?aoa?ao?" aeic aeine?aeaeaiiy i?e?ii?aai?ci?a, yeee aeionea? iaaee/iee iaoeiai-ae?iaie/ee oeaio? “A?inai” (i. A?iieoey). Eeiii/iee iaoa?iae neeaee 192 iaoe??ioe c AAO oa oieanoaoe/iith II i?e aeia/ieai'yiie oai?iai, yei aoee iia?iaaii a eeiiioei oieoaeueii? oi?o?ai?. O 52 i?iaiaeeeinue eiiieaenia e?eoaaiiy ca ?ic?iaeaieie iaoiaeeeaie c ?io?aoieaaeioaaeueiei aaaaeaiiyi aioea?ioee?a oa ?io?aoieaaeioaaeueiei ?icoaooaaiiyi aeoeaiiai aeaeo?iaeo (18) aai iaoe??iei ?icoaooaaiiyi aeaeo?iae?a (34). Eiio?ieuei? a?oie neeaee 44 iaoe??ioe, yeei i?iaiaeeany aioo??oiueioeaieiiee aeaeo?ioi?ac ca iaoiaeeeith ee?i?ee oieoaeueii? o??o?a?? Aoeiaeinueei? aea?aeaaii? iaaee/ii? aeaaeai??, oa 96, o yeeo iaoiaee i?io?eaeoeee oa e?eoaaiiy a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? aoee o?aaeeoe?eieie. Aie oai?eo eieeaaany aiae 22 aei 86 ?ieia. C iaoith ia'?eoeaii? ioeiiee ?ic?iaeaieo oa ai?iaaaeaeaieo iaoiaeia eieoaaiiy AAO oa II a ?aiiueiio iineyiia?aoeieiiio ia?iiaei a eeiii/ieo oiiaao iaie aeeiiaii anaa?/i? caaaeueii eaai?aoi?ii oa a?io?i?/i? ianoaaeaiiy ca caaaeueiii?eeiyoeie iaoiaeeeaie. Aei??thaaiiy ciiie ?I aeia/? oa ieoiiiai aeaeo?e/iiai iii?o aeia/? i?iaiaeeeinue aiaeia?/ii aenia?eiaioaeueiei aeine?aeaeaiiyi. Ani io?eiai? iieacieee i?ieoee aa?iaoeieii-noaoenoe/io ia?iaeo ia IAII 386 SX ca i?ia?aiith "FoxPro 2.0" (c) 1989, 1991 Fox Holdings, Inc. oa PC IBM–486 ca i?ia?aiith “Exell-5”. Iniiai? ?acoeueoaoe aeine?aeaeaiiy. Aea/aiiy aeaeo?ii?ia?aeiino? oeaiei aaiaoi-a?e?a?ii? nenoaie a oiiaao AAO oa II cana?ae/eei, ui iioeiaeueiei aeey e?ea?aeaoe?? caiaeueieo ci?i o aeia/iaea?aeieo oeyoao i?e AAO a i?neyiia?aoe?eiiio ia??iae? ? aa?iaio c ?icoaooaaiiyi iiceoeaiiai aeaeo?iaeo a i?inaioi ae?aiaaeo caaaeueii? aeia/ii? i?ioiee, a aiae'?iiiai aieaoa?aeueiiai iaoei?ii a i?iaeoe?? ia/iiee. I?e aieeai AIIN iecueei? uieueiinoi (iaioa 1,4 iA/ni2 iiaea/? no?oio ia aia?ao?) iae?aco iiney naaino aaeueaaiicaoei? ?H c?inoa? aei 6,8 a ia?oo aeiao. Iiney 4 aiaeei ?H ciaioo?oueny aei aeoiaeiiai ?iaiy. AIIN iecueei? uieueiinoi i?ecaiaeeoue aei ii?iaeicaoei? iieacieeia ?H ia 6-7 aeiao iiney iia?aoei?. Iiaia eieaiaeaoeiy caiaeueiiai i?ioeano o aeia/iaea?aeieo oeyoao aiaeaoaa?oueny ia 10 aeiao. Iieacieee IAI aeia/i aei?iaiththoue 54,131,58 Ii/ni (p<0,001). I?e iaoei?i?e eieae?caoe?? iaio aeaeo?iaeia ia 5 aeiao ?H aeia/i aei?iaith? 6,730,36, ia 7 aeiao 7,040,32, a ii?ie aeinyaa? eeoa ia 9-10 aeiao. IAI ii?iaeico?oueny ia 11-12 aeaiue iiney iia?aoei?. A 3-e a?oi? iieacieee aeinyaathoue iaae ii?ie ia 9-10 aeiao iineyiia?aoeieiiai ia?iiaeo. Aea/aiiy aieeao AIIN na?aaeiuei? uieueiinoi (a iaaeao 0,05-0,015 iA/ni2) canaiae/eei (1-oa a?oia), ui ?H aeia/i c?inoaea aei 7,5-7,8 iae?aco iiney 1-ai naaino aaeueaaiicaoei?. *a?ac 8 aiaeei iiney i?iaaaeaiiy naaino ?H aeia/i ciaiooaaeinue aei 6,4-6,5. I?e uiaeaiiiio aieea? AIIN na?aaeiuei? uieueiino? a 2-e oa 3-e a?oiao oaa?ei ii?iaeicaoeiy iieacieeia ?H aiaeaoaa?oueny ia 4-5 aeiao, a a 1-e a?oi? – ia 7-8 aeiao. IAI aeia/i a 1-e a?oi? ia 7 aeiao aei?iaithaaa 82,261,94 Ii/ni (p<0,01), a inoaoi/ii ii?iaeicoaaany eeoa ia 11-12 aeiao. A 2-e a?oii aaea ia 5 aeiao ?H aeinyaaa cia/aiue 7,580,30 (p<0,05), ia 7 aeiao 7,720,14 (p<0,05) i iaaeaei ia aeoiaeea ca iaaei ii?ie. Aiaeiiaiaeii iieacieee IAI noaiiaeee 64,371,67 (p<0,001) oa 56,241,82 Ii/ni (p<0,001), oiaoi niinoa?iaa?oueny a?eueo oaeaeea eieaiaeaoeiy caiaeueiiai i?ioeano a ii?iaiyiii c iioeie a?oiaie. Iiaoi?iee aieea AIIN aeniei? uieueiinoi i?ecaiaeeoue aei iioeiaeaeoth/i? aei? ia iaia?aie iio?aeiaoey?ieo i?ioieia, ui iie?ineiii/ii aeyaey?oueny o aeaeyaei aaiiaiei?; ?H aeia/i i?e oeueiio iiaeaeuo?oueny aei 9,8-10,0. Oea naiae/eoue i?i ?icaeoie ia/?ieiai? iaaeinoaoiino? oa ? iani?eyoeeaith i?iaiinoe/iith iciaeith. I?e aiaeoai?aii? aenia?eiaioaeueii? ea?oeie iaoo?aoeieii? aeiaoyieoei c ?icaeoeii IH oa AAO a eiio?ieueiie a?oii a ia?oo aeiao IAI aeia/i ciaioo?oueny aei 34,260,52 Ii/ni, oiaei ye ?H aei?iaith? 9,780,18. Ha 7-8 aeiao ii/eia? ca?eueooaaoenue IAI aei 42 Ii/ni, a ?H iinooiiai ciaioo?oueny aei 8,5. Hi?ie iieacieee iaaoaathoue ia 14-16 aeiao iiney iia?aoei?. I?e aieeai AIIN iecueei? uieueiinoi iiaea/? no?oio ia aia?ao? (0,7-1,4 iA/ni2) iae?aco iiney naaino aaeueaaiicaoei? a 2-e a?oi? ?H noaiiaeoue 9,8 a ia?oo aeiao. Ii?iaeicaoeiy iieacieeia ?H oa IAI niinoa??aa?oueny ia 6-7 aeiao iiney iia?aoei?. I?e aieea? AIIN u?eueiinoth iiaea/? no?oio ia aia?ao? 1,5 - 2.8 iA/ni2 ?H aeia/i iaaeeaeaeinue aei ii?ie ia 9-10 aeiao. Aeey i?iaaaeaiiy /a?acoei?ii? aaeueaaiicaoei? iioeiaeueiith aonoeiith no?oio ? 0,05-0,1 iA/ni2. Iiney ia?oiai naaino ?H aeia/i ciaiooaaany aei 9,7. Hi?iaeicaoeiy iieacieeia ?H niinoa?iaaeanue ia 9-10 aeiao. I?e 3-io aa?iaio? ?icoaooaaiiy aeaeo?iae?a ii?iaeicaoeiy ?H aeia/i aiaeaoaa?oueny ia 8-9 aeiao i?e aieeai no?oiii na?aaeiuei? uieueiino? oa ia 7-8 aeiao i?e aieeai AIIN iecueei? uieueiinoi. Aea/aiiy aioei?e?iaii? ae?? AIIN aeyaeei, ui /a?acoe??iee aieea no?oiii iecueei? u?eueiino? eeoa iacia/ii aieeaa? ia e?euee?niee neeaae i?e?ioei?e, ciaiooth/e eiioeaio?aoe?th c 11,00,19 lg EOI/ie a ia?oo aeiao aei 7,780,11 lg EOI/ie iai?ee?ioe? 4-i? aeiae. A 2-e a?oi? a?aeiia?aei? iieacieee ciaioeeenue c 10,780,15 lg EOI/ie aei 6,020,07 lg EOI/ie oa a 3-e a?oi? c 10,260,25 lg EOI/ie aei 6,680,09 lg EOI/ie. Ia?aaaaeii aen?aaeanue eeoeiaa oei?a (E.coli oa Str. Faecalis). I?e aieea? AIIN na?aaeiuei? aonoeie c 2-i? aeiae iieacieee i?e?iaii? caa?oaeiaiino? aeia/? cia/ii iaio? a 2-e a?oi? a ii??aiyii? c eiio?ieai oa ?ioeie aeine?aeieie a?oiaie, a iai?ee?ioe? aeine?aeaeaiiy ciaioothoueny aei 4,600,07 lg EOI/ie. I?e ae?? AIIN aeniei? u?eueiino? aaea i?ney ia?oiai naaino i?aeaeuoaaeanue /ooeea?noue aeae?eaii? c aeia/? eoeueoo?e i?e?ii?aai?ci?a aei eaaii?oeaoeio aei 24,2±0,8 ii. I?ney 2-ai naaino c?inoa? /ooeea?noue aei aii?oeee?io (24,7±0,6) oa aaioai?oeeio (15,4±0,6). I?ney 5 naaino /ooeea?noue aei aii?oeee?io noaiiaeea 17,6±0,3 ii (p<0,05), aei aaioai?oeeio 19,6±0,4 ii (?<0,05); aei eaaii?oeaoeio, oeaoioaeneio oa eaiai?oeeio i?aeoe/ii ia ci?ithaaeanue a ii??aiyii? c aeo?aeieie aeaieie, a?aeiiaethaaeanue /ooeea?noue aei aeien?oeeee?io. Aieea AIIN aeniei? u?eueiino? a??ia?aeii i?aeaeuo? /ooeea?noue aeae?eaieo c aeia/? eoeueoo? aei aii?oeee?io, aaioai?oeeio oa aeien?oeeee?io. I?e niinoa?aaeaiiyo ca aeaeieaiiyi aeia/i i?ney aeaeiii?ani? aeia/iaea?aeieo oeyoia a eiio?ieueiie a?oii oaa?ei na?aaeiy eieueeinoue aeia/i i?ioyaii ia?oi? aiaeeie noaiiaeea 14-16 ie/aiae, a i?ioyaii aeiae – 6-8 ie/aiae, iath/e oaiaeaioeith aei ciaioaiiy. Aiaeiiaeaiiy aeae?eaiiy aeia/? ii/eiaeinue c 6-7 aeiae oa inoaoi/ii caaa?ooaaeinue /a?ac 18-20 aeia. O an?o a?oiao oaa?ei i?e aieea? AIIN iecueei? uieueiinoi caieueoaiiy aeaeieaiiy aeia/i ii/eiaeinue iai?eeiioei i?iaaaeaiiy 1-aiaeeiiiai naaino aaeueaai?caoei?. Aeaaio aeia/i caieueooaaany a 2,2-2,6 ?ace. AIIN iecueei? u?eueiino? a 2-e oa 3-e a?oiao caieueooaaei nae?aoeith aeia/i a 3,3-3,5 ?ace. Noeioeueiaaia nae?aoeiy a ia?oo aeiao niinoa?iaa?oueny ia i?ioyci 4-6 aiaeei, a ia ae?oao aeiao – ia i?ioyci 12-14 aiaeei. Iiney 4-5-ai naaino, ye i?aaeei, nae?aoi?ia ooieoeiy ia/iiee ii?iaeicoaaeanue. Canoinoaaiiy AIIN aeniei? uieueiinoi i?eaii/oaaei nae?aoi?io ooieoeith ia/iiee. A na?i? eeiii/ieo aeineiaeaeaiue aea/aii 192 oai?eo ia oieaiaioe, iia?iaaieo ao?o/aiiy c i?eaiaeo aeia/ieai'yii? oai?iae. A eiio?ieuei?e a?oi? 1 (96) aaaeaiiy a iineyiia?aoeieiiio ia?iiaei aoei caaaeueiii?eeiyoei. A eiio?ieuei?e a?oi? 2 (44) aeei?enoiaoaaeanue iaoiaeeea aeaeo?ioi?aco c aioo??oiueiaaiiei oa aioo??oiueiiycaaei aaaaeaiiyi aioea?ioee?a. O 52 oai?eo canoiniaoaaee ?io?aoieaaeioaaeueia aaaaeaiiy aioei?e?iaieo i?aia?aoia oa aaeueaaiicaoeith c aeoeaiei aeaeo?iaeii o i?ina?o? ae?aiaaeo caaaeueii? aeia/ii? i?ioiee (18) aai iaoe??iith eieae?caoe??th aeaeo?iae?a (34). ?iciiae?e oai?eo a a?oiao ca a?eii oa noaooth aoa aiiiaaiiei. Ia'?i iia?aoeaiiai ao?o/aiiy caeaaeaa aiae noaio oai?iai, oa?aeoa?o ? noaaei? iniiaiiai oa noiooiio caoai?thaaiue, i?iya?a II. A i?neyiia?aoe?eiiio ia??iae? o iniiai?e a?oi? oai?eo ?io?aoieaaeioaaeueii aaiaeeee aioea?ioeee (/ano?oa aaioai?oeei, aii?oeee?i aai oeaoaeinii?eie ia 10–20 ie i?ae?a??oiai 0,25% ?ic/eio iiaiea?io) aai 10-20 ie 0.5% ?ic/eio ae?ieneae?io c i?iaaaeaiiyi naain?a aioo??oiueioeaieiiiai aeaeo?ioi?aco. Aieea AIIN ii/eiaee /a?ac 12-24 aiaeeie iiney iia?aoei? (91 oai?ee). Aaeueaaiicaoeiy aeieyiee ia/iiee noi?iaiaeaeo?oueny iiiioiei (a 2,2-2,6 ?ac?a) caieueoaiiyi aeia/iaiaeaeieaiiy ii ae?aiaaeo a ia?oo aeiao iiney iia?aoei?. A ia?o? aeiae i?ney iia?aoe?? aeia/, a?aoiaoth/e yaeua caiaeaiiy o iicaia/iieiaeo aeia/ieo oeyoao, a aeaaiaaeoeyoeiaeo eeoeo i?aeoe/ii ia iaaeoiaeeoue ? aeae?ey?oueny ii ae?aiaaei?e o?oaoe?. Iioii, iiae aieeaii ii?aeiaiiai canoinoaaiiy aioeaiioeeo, i?ioecaiaeueieo caniaia oa aaeueaaiicaoei? i?aai?a aaiaoi-a?e?a?ii? nenoaie, a?aeaoaa?oueny ciaioaiiy caiaeueiiai i?ioeano, ui noai?th? ni?eyoeeai oiiae aeey aiaeoieo aeia/i o aeaaiaaeoeyoeiaeo eeoeo. Oea aeyaey?oueny ciaioaiiyi eieueeinoi aiaeoiaeia aeia/i ii ae?aiaaeo. Iieacieee o?ceei-o?i?/ieo ia?aiao??a aeia/i ia caeaaeaoue a?ae i?noey caai?o aeia/? c a?e?a?ii? nenoaie. O oai?eo an?o a?oi IAI aeia/? a 1-o aeiao i?ney iia?aoe?? ia? aenie? iieacieee ? eieeaa?oueny a ??cieo a?oiao a?ae 124,351,88 aei 129,462,24 Ii/ni, a ?I aeia/? a 1-o aeiao i?ney iia?aoe?? neeaaea? 6,180,73 – 6,250,82. O oai?eo 1-i? eiio?ieueii? a?oie oae? iieacieee aeia/? caa??aathoueny aei 6-7 aeiae i?aeoe/ii aac ci?i, ii/eiath/e c 8-9 aeiae IAI ciaioo?oueny aei 100 Ii/ni, a ?I c?inoa? aei 7,0. Ia 12 aeiao ?I ia?aaoaa? a iaaeao ii?ie ? noaiiaeoue 7,880,14, oiae? ye IAI caeeoa?oueny aeaui aeuei ca ii?io, ui na?ae/eoue i?i iaiiaio e?ea?aeaoe?th caiaeueiiai i?ioeano o aeia/iaea?aeieo oeyoao. Oaiaeaioe?y aei ii?iae?caoe?? o?ceei-o?i?/ieo ia?aiao??a aeia/? o oai?eo 2-i? eiio?ieueii? a?oie c’yaey?oueny aaea ia 5-oo aeiao c iiiaioo iia?aoe??, ia 7 aeiao IAI aeia/? noaiiaeoue 72,541,32 Ii/ni, a ?I 7,380,23. Inoaoi/ia ii?iae?caoe?y niinoa??aaeanue ia 10-11 aeiao. Aei oeueiai /ano IAI noaiiaea 56,170,57 Ii/ni. O oai?eo aeine?aeii? a?oie i?ney ii/aoeo canoinoaaiiy AIIN aaea ia 3-oth aeiao ?I aeia/? i?aeaeuo?oueny aei 6,980,42, a IAI ciaioo?oueny aei 108,562,11 Ii/ni. Aei ii?ie iieacieee iaaeeaeathoueny ia 6-7 aeiao ? a iiaeaeueoiio caeeoathoueny a iaaeao ii?ie. Ia 7 oa 10 aeiao ?I noaiiaeoue 7,690,09 ? 7,780,07, a IAI, a?aeiia?aeii, 62,261,83 oa 57,431,86 Ii/ni. Aeey i?iaaaeaiiy ?aoe?iiaeueii? aioea?ioeeioa?ai?? i?iaiaeeeinue i?e?ia?ieia?/ia ianoaaeaiiy aeia/?, i?e yeiio i?e?ioei?a aeae?eaia o 96,8% aeiaaee?a. Iae/anoioa aeniaaeenue eeoeiaa iaee/ea oa aioa?ieiee. I?e?ioei?a aoea ?acenoaioiith aai iaei/ooeeaith aei aioea?ioee?a o 64,5% aeiaaee?a. Iaea?eueoa /ooeea?noue aecia/aeanue noiniaii aii?oeee?io oa oeaoaeinii?ei?a. I?e ?io?aoieaaeioaaeueiiio ?icoaooaaii? aeoeaiiai aeaeo?iaeo a?aecia/a?oueny a?eueo oaeaeea ciaioaiiy yaeu ?io?eoaaiiy aeia/?. Canoinoaaiiy AIIN a eiiieaeniiio e?eoaaii? a ?aiiueiio iineyiia?aoeieiiio ia?iiaei o oai?eo ia AAO i?e aeia/ieai'yiie oai?iai aeicaieeei ciaioeoe e?euee?noue oneeaaeiaiue aiieii-naioe/iiai oa?aeoa?o ia 9,6% oa, caaaeyee oeueiio, nei?ioeoe oa?i?ie noaoe?iia?iiai e?eoaaiiy c 22,641,61 aei 16,881,31 (p<0,01). Iaie i?iaaaeaii aiae?c 58 ?noi??e oai?ia iaoe??io?a, o yeeo ia?aa?a oieaia?oo oneeaaeithaaany ?icaeoeii oieanoaoe/ii? II c ???-?V nooiaiai iaoai?/ii? aeiaoyieoe?. Nooi?iue iaoai?/ii? aeiaoyieoe? oa aino?i? II, ui ?? noi?iaiaeaeo?, aecia/aee ca eeaneo?eaoe??th A.I. Ceiaae/a oa ni?aaao. Aeaeiiiainiaaia aeiaoyieoey (??? nooi?iue) oa?aeoa?eco?oueny aenieei ai?noii a e?ia? a?e??oa?io – 101-200 ieiieue/e. I?e oa?i?iaeuei?e aeiaoyieoe? (?V nooi?iue) a?e??oa?iai?y ia?aaeuo? 200 ieiieue/e, aiia noi?iaiaeaeo?oueny ae?aaeaiei i?eai?/aiiyi na?aeiiino?, ciaioaiiyi aeiaiaiai ae?o?aco aei 400-500 ie, ?icaeoeii na?oeaai-noaeeiii? iaaeinoaoiino?. *ano?oa anueiai aino?a II ?icaeaaeanue o oai?eo noa?oiai a?eo (61-80 ?ie?a). A?eueo?noue a?oie neeaaeaee /ieia?ee – 43 iniae (74,14%). Iniiaio a?oio (17) neeaee oai??, o yeeo aacenia oa?ai?y aeiiiaithaaeanue a i?neyiia?aoe?eiiio ia??iae? aioo??oiueioeaieiiei aeaeo?ioi?acii c ?io?aoieaaeioaaeueiei aaaaeaiiyi aioei?e?iaieo i?aia?ao?a. Eiio?ieueio a?oio 1 neeaee 25 iaoe??io?a, yeei i?iaiaeeeinue eeoa caaaeueiii?eeiyoi? iaoiaee e?eoaaiiy. A eiio?ieuei?e a?oi? 2 (16) o aeiaeaoie aei aacenii? oa?ai?? i?iaiaeeany aioo??oiueioeaieiiee aeaeo?ioi?ac c iaoe??iei ?icoaooaaiiyi iaio aeaeo?iae?a. Aioei?e?iai? caniae aaiaeeeenue aioo??oiueiaaiii. Ia?aaeiia?aoeieia iiaeaioiaea i?iaiaeeeanue c o?aooaaiiyi eaai?aoi?ieo iieacieeia oa iayaiino? noiooiuei? iaoieia??. Ia'?i iia?aoeaiiai ao?o/aiiy caeaaeaa aiae noaio oai?iai, noaae?? ia/?ieiai? iaaeinoaoiino? oa eiiiainaoe?? noiooiio caoai?thaaiue. Aoaeoeai?noue e?eoaaeueieo caoiae?a ioe?ithaaee ca aeeiai?eith caaaeueiiai noaio oai?eo, ii?iae?caoe??th aaiiaeeiai?ee, eaai?aoi?ieie iieacieeaie oa e?euee?nieie iieacieeaie aeia/?, ui aeae?eyeanue ii ae?aiaaeo c caaaeueii? aeia/ii? i?ioiee. Iaa?oue a ia?oo aeiao i?ney iia?aoe??, i?e yaeuao ae?aaeaii? oieanoaoe/ii? II, niinoa??aa?oueny nooo?aa ??cieoey i?ae aeia/iaeae?eaiiyi o oai?eo ??cieo a?oi. Aiii ? a?eueoei o iaoe??io?a iniiaii? a?oie, i?e/iio iae?ineii?/ii aeae?ey?oueny oaiia aeia/, a oie /an ye o oai?eo 1-i? eiio?ieueii? a?oie aeia/ neaaicaaa?aeaia, oae caaia “a?ea aeia/”. C 6-7 aeiae a?aeiiaeth?oueny ianaae aeia/? o aeaaiaaeoeyoeiaeo eeoeo. I?iaaaeaia aeine?aeaeaiiy o?ceei-o?i?/ieo ia?aiao??a aeia/i o oai?eo c II aeyaeei, ui e?eoe/ieie aeey oieanoaoe/ii? II ? IAI ieae/a 33 Ii/ni oa i?aeaeuaiiy ?I aei 10,0. Iieacieee IAI aeia/? a 1-oo aeiao i?ney iia?aoe?? ciaioothoueny aei i?i?ioio ? a na?aaeiueiio noaiiaeyoue 34 Ii/ni, a ?I aeia/? neeaaea? 9,74±0,26 - 9,76±0,18. O oai?eo 1-i? eiio?ieueii? a?oie ia 7 aeiao i?ney iia?aoe?? IAI noaiiaeoue 40,42±1,12 Ii/ni, a ?I ciaioo?oueny aei 8,96±0,12. Ia 10 aeiao IAI i?aeaeuo?oueny aei 48,26±1,20 Ii/ni, a ?I aei??aith? 8,62±0,17. Ia 12 aeiao c iiiaioo iia?aoe?? iieacieee eeneioii-eoaeii? ??aiiaaae oa IAI aeinyaathoue iaae ii?ie ? noaiiaeyoue, a?aeiia?aeii, 8,20±0,11 oa 52,64±0,96 Ii/ni. O oai?eo 2-i? eiio?ieueii? a?oie IAI aeia/? ia 7 aeiao noaiiaeoue 47,56±1,36 Ii/ni, a ?I 8,76±0,17. Aei 10-i? aeiae o a?eueoino? oai?eo iieacieee ?I aeinyaaee ii?ie. A iniiai?e a?oi? aei ii?ie iieacieee ?I iaaeeaeathoueny ia 8 aeiao, a IAI ia aeiao ?ai?oa. Ia 7 oa 10 aeiao ?I noaiiaeoue 8,61±0,13 ? 8,02±0,09, a a?aeiia?aei? iieacieee IAI 48,22±1,04 oa 52,24±1,02 Ii/ni. Ii?iaiyiiy aeeiaiiee eaai?aoi?ieo aeaieo aeaco? ia aieueo ni?eyoeeaee ia?aaia ?aiiueiai iineyiia?aoeieiiai ia?iiaeo o oai?eo c II, yeei i?iaiaeeeanue eiiieaenia iioaineaia oa?aiiy a ?aiiueiio iineyiia?aoeieiiio ia?iiaei a ii?aeiaiii c o?eaaeith aaeueaaiicaoei?th i?aai?a aaiaoia?e?a?ii? nenoaie. Hacaaaeath/e ia iioaineaio oa?ai?th, a eiio?ieuei?e a?oi? 1 a 27,58% aeiaaeeia o oai?eo ia AAO oa II io?eiai? eaoaeuei? ?acoeueoaoe aiane?aeie aaiaoa?a?? (75%), i?ia?anoaaiiy na?oeaai-noaeeiii? iaaeinoaoiino? (18,75%), i?ia?anoaaiiy ia?eoii?oo 6,25%. Cai?iiiiiaaia iaoiaeeea aeicaieeea iai nei?ioeoe caaaeueiee eiaeei-aeaiue c 24,941,16 aei 19,590,84 (p<0,01). Aeniea eieoaaeueia oa aeiiiii/ia aoaeoeaiinoue ?ic?iaeaiiai iaie iaoiaeo eieoaaiiy oai?eo ia AAO oa oieanoaoe/io II i?e aeia/ieai'yiie oai?iai a ?aiiueiio iineyiia?aoeieiiio ia?iiaei, oaoii/ia i?inoioa, iaaaeeea aa?oinoue, iaaeathoue iiaeeeainoue canoiniaoaaoe eiai a aoaeue-yeeo oi?o?ai/ieo aiaeaeieaiiyo c iaoith iie?auaiiy ?acoeueoaoia eieoaaiiy oai?eo. Aeniiaee 1. Iaeaieueo ?aoeiiiaeueiei aeey e?eoaaiiy aino?eo ai?eieo oieaia?o?a a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? ? ii?aeiaia canoinoaaiiy aioei?e?iaieo cania?a c ae??th aeaeo?e/iiai iiey iinoieiiai no?oio c aonoeiith iiaea/? no?oio a aeia/? 1,5-2,8 iA/ni2 i?e ?io?aoieaaeioaaeueiiio ?icoaooaaii? aeoeaiiai aeaeo?iaeo. O aeiaaeeao oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino? c iaoai?/iith aeiaoyieoeath ???-?V no. iaea?eueo iioeiaeueiei ? aieea aeaeo?e/iiai iiey aonoeiith iiaea/? no?oio a aeia/? 0,7-1,4 iA/ni2, yea ia? aeanoeaino? noeioethth/i? ae?? ia nae?aoi?io ooieoe?th ia/?iee. 2. Aaeueaaiicaoeiy i?aai?a aaiaoia?e?a?ii? nenoaie i?e aino?iio ai?eiiio oieaia?o? oa oieanoaoe/i?e ia/?ieia?e iaaeinoaoiino? (ca aenia?eiaioaeueieie aeaieie) i?e aonoei? iiaea/? no?oio a aeia/? a iaaeao aei 0,7 iA/ni2 i?aeoe/ii ia aieeaa? ia ii?iae?caoe?th o?ceei-o?i?/ieo ia?aiao??a aeia/?. Aeaeo?e/ia iiea iino?eiiai no?oio aonoeiith iiaea/? no?oio 1,5-2,8 iA/ni2 ni?ey? ii?iae?caoe?? ieoiiiai aeaeo?e/iiai iii?o oa ?I aeia/? i?e aino?iio i?neyiia?aoe?eiiio oieaia?o? ia 3-4 aeiae ?ai?oa. 3. Eieaeueia eiioeaio?aoe?y aeeoo?caeaoieo iaoiaaiieo oa oiiaii iaoiaaiieo i?e?ii?aai?ci?a o aeia/? i?yiii?iii?oe?eii caeaaeeoue a?ae aonoeie aeaeo?e/iiai iiey iino?eiiai no?oio. Iaea?eueo ae?aaeaiee aaeoa?eoeeaeiee aoaeo aeyaey? aeaeo?e/ia iiea iino?eiiai no?oio aonoeiith a aeia/? 1,5-4,2 iA/ni2 a?aeiinii E.coli, Str.faecalis. 4. Aeaeo?e/ia iiea iino?eiiai no?oio ??cii? aonoeie aieeaa? ia /ooeea?noue iaoiaaiieo oa oiiaii iaoiaaiieo i?e?ii?aai?ci?a aei aioea?ioee?a. *ooeea?noue ooai?a E.coli aei aaioai?oeeio ca?eueoo?oueny i?yiii?iii?oe?eii aonoei? no?oio (a?ae 11,60,4 aei 19,60,4). Iioeiaeueiei aeey canoinoaaiiy a ee?i?/ieo oiiaao ? aeaeo?e/ia iiea iino?eiiai no?oio aonoeiith iiaea/? no?oio 1,5-2,8 iA/ni2. 5. ?ic?iaea oa ai?iaaaeaeaiiy a i?aeoeeo niinia?a e?eoaaiiy aino?iai ai?eiiai oieaia?oo oa ia/?ieiai? iaaeinoaoiino? a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? aeicaieeei iai ciaioeoe e?euee?noue ai?eii-caiaeueieo oneeaaeiaiue ia 9,6% oa i?neyiia?aoe?eiee e?aeei-aeaiue i?e e?eoaaii? oieaia?o?a c 22,641,61 aei 16,881,31 (p<0,01) oa i?e ia/?ieia?e iaaeinoaoiino? c 24,941,16 aei 19,590,84 (p<0,01). I?aeoe/i? ?aeiiaiaeaoe?? 1. Aeey i?iaaaeaiiy aioo?ioiueioeaieiiiai aeaeo?ioi?aco i?e oieaia?oao c iaoai?/iith aeiaoyieoeath ?-?? no. i?ney i?iieaaiiy ae?aiaaeo caaaeueii? aeia/ii? i?ioiee 0,25% ?ic/eiii iiaiea?io a ae?aiaae aaiaeyoue iaaeeeaiaioicio noi?o (10-20 ie 0,25% oaieiai ?ic/eio iiaiea?io c ?ic/eiaiei aioeaiioeeii o iioeiaeueiie aeici (eaiaiioeei – 1 a, aaioaiioeei - 80 ia, aii?oeee?i 0,5 a) aai 10 ie 0,5% ae?ieneaeeio)). A ae?aiaaeio o?oaeo caaaeueii? aeia/ii? i?ioiee aaiaeeoueny noa?eeueiee eaoaoa?iee aeaeo?iae ia cacaeaeaa?aeue aei??yio aeeaeio oaeei /eiii, uia a?i ia aeioiaeea ia 2-3 ni aei ae?aiaaeieo ioai??a. Ae?aiaaeio o?oaeo ia?ae?eaathoue caoenea/ai. Ia ciio ia/iiee nia?aaeo oa ccaaeo iaeeaaeathoue a?eaoa?aeuei? aeaeo?iaeii i?ieeaaeee ieiuath 300-400 ni2. Eaoaoa?iee aeaeo?iae i?aeeeth/athoue aei eeaie “+”, a?eaoa?aeuei? aeaeo?iaei? i?ieeaaeee – aei eeaie “”. Aaeueaaiicaoeith i?iaiaeyoue ca aeiiiiiaith aia?aoo "Iioie-1" i?e aonoeii no?oio iiaea/? a aeia/? 1,5-2,8 iA/ni2 ia i?ioyci 60 oaeeei (i?e oeueiio aonoeia no?oio i?ioiaeaeaiiy a oeaieiao ia ia?aaeuo? 0,1 iA/ni2). *a?ac 30 oa., a i?e iiya? ?icie?ath/eo aieae a i?aaiio i?ae?aaa?? (i?e iayaiino? iaa?yeo p. Fateri) ?ai?oa, a?aee?eaathoue ae?aiaaeio o?oaeo. Eo?n eieoaaiiy 5-7 naainia. I?ney aecia/aiiy /ooeeainoi i?e?ioei?e aeia/? aei aioeaiioeeia i?iaiaeeoueny cai?ia aioea?ioee?a a i?ioean? e?eoaaiiy c o?aooaaiiyi aioea?ioeeia?aie. 2. I?e iaoe??i?e eieae?caoe?? iaio aeaeo?iae?a ieiuath 300-400 ni2 i?ae /an i?iaaaeaiiy aaeueaai?caoe?? ca aeiiiiiaith aia?aoo "Iioie-1" c aonoeiith no?oio 0,03-0,05 iA/ni2 ia i?ioyc? 60 oaeeei ?io?aoieaaeioaaeueii /a?ac ae?aiaae aaiaeyoue e?aiaeueii c /anoioith 10-20 e?aiaeue/oa 100 ie 0,9% ?ic/eio NaCl c ?ic/eiaiei aioea?ioeeii o iioeiaeueiie aeici (eaiaiioeei – 1 a, aaioaiioeei - 80 ia, aii?oeee?i 0,5 a aai 10 ie 0,5% ae?ieneaeeio). Cai?ia aioea?ioee?a a i?ioean? e?eoaaiiy i?iaiaeeoueny c o?aooaaiiyi aioea?ioeeia?aie. Eo?n eieoaaiiy 5-7 naainia. 3. Canoinoaaiiy aioeaiioeeia oa aioei?e?iaieo cania?a ii?aeiothoue c aioo?ioiueiaaiiei aaaaeaiiyi aetheici-aioaiiiieo noiioae, eiea?aieneeace (100 ia), oei?enoiai eaeueoeith (10%-10 ie), aooieiio (2,4%-10 ie) i?ae /an naain?a aeaeo?ioi?aco. Ii?o/ c oeei i?iaiaeyoue ei?aeoeith aeaeo?ieioii?, eeneioii-eoaeii? ?iaiiaaae, aieeiaiai aaeaino, aeaoieneeaoeieio oa?aiith. 4. Iaoiaeeea aioo??oiueiii?iaeieiiiai aeaeo?ioi?aco i?e oieanoaoe/i?e ia/?ieia?e iaaeinoaoiino? c iaoai?/iith aeiaoyieoeath ???-?V no. ia? aeaye? a?aei?iiino? a?ae aiaeia?/ii? i?e ?cieueiaaiiio oieaia?o?. *a?ac 30 oa. i?ney ii/aoeo naaino i?iythoue iiey?i?noue aeaeo?iae?a ia?aeeth/aiiyi eeai ia aia?ao? c iaoith noeioethaaiiy aeae?eaiiy a?ea?aiiaoii? o?aeoe?? aeia/?. Aonoeia no?oio iiaea/? a aeia/? 0,7-1,4 iA/ni2. Eo?n eieoaaiiy 7-10 naainia. Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe?? 1. A?aaaithe A.?., ?ooiae?e A.A., Iaoe?ai?a A.A. Eiiieaenia o??o?a?/ia e?eoaaiiy oai?eo c ai?eieie oieaia?oaie oa ia/?ieiaith iaaeinoaoi?noth ca aeiiiiiaith ciiaeueiiai aioo??oiueioeaieiiiai aeaeo?ioi?aco // A?niee iaoeiaeo aeine?aeaeaiue. - 1998. - ? 5-6. - N. 14-15. 2. A?aaaithe A.?., ?ooiae?e A.A. No/ani? i?aeoiaee aei e?eoaaiiy ai?eiiai oieaia?oo (iaeyae e?oa?aoo?e) // Aoeiaeinueeee iaaee/iee a?niee. – 1998. O.2. - ? 4. – N.199-204. 3. Iaoaio 23140 A Oe?a?ia, IIE G09 A23/28, A61A10/00. Niin?a iiaeaethaaiiy aino?iai aenia?eiaioaeueiiai oieaoeenoeoo / ?ooiae?e A.A., Neaei?/oe ?.E., A?aaaithe A.?.; Cayaea ? 97031215 a?ae 18.03.97 ?., iioae. 30.06.98, Athe. ? 3. 4. Cayaea ? 97073445 a?ae 01.07.97 ?. Niin?a ?aa?iia?ii? aioea?ioeeioa?ai?? caiaeueieo caoai?thaaiue a?e?a?ii? nenoaie / ?ooiae?e A.A., Aeaena?iei I.A., A?aaaithe A.?. Iiceoeaia ??oaiiy i?i aeaea/o Iaoaioo Oe?a?ie a?ae 01.12.98 ?. 5. Cayaea ? 97073446 a?ae 01.07.97 ?. Niin?a e?eoaaiiy caiaeueieo caoai?thaaiue aeia/iiai i?oo?a oa iicaia/?ieiaeo aeia/ieo i?ioie?a /?ooiae?e A.A., Aeaena?iei I.A., A?aaaithe A.?. Iiceoeaia ??oaiiy i?i aeaea/o Iaoaioo Oe?a?ie a?ae 01.12.98 ?. 6. ?ooiae?e A.A., Aeaena?iei I.A., Na?iei A.O., A?aaaithe A.?. Eiiieaenia i?io?eaeoeea oa e?eoaaiiy i?neyiia?aoe?eieo oneeaaeiaiue ai?eii-naioe/iiai oa?aeoa?o c aeei?enoaiiyi iino?eiiai no?oio a o??o?a?? //Iaoiaee/i? ?aeiiaiaeaoe??. - *a?i?aoe?, 1996. - 24 n. 7. ?ooiae?e A.A., A?aaaithe A.?. E?eoaaiiy ai?eieo oieaia?o?a c aeei?enoaiiyi aeaeo?e/iiai iiey iino?eiiai no?oio // Iao. i?aeia?. iaoe. eiioa?aioe?? "Aeooaeuei? ieoaiiy no/anii? o??o?a??". – Oaeai?iae, 1997. – N. 67-68. 8. ?ooiae?e A.A., Aeaena?iei I.A., A?aaaithe A.?. E?eoaaiiy i?neyiia?aoe?eiiai oieaia?oo // ?? Eiia?an o??o?a?a Oe?a?ie: Ca. iaoe. ?ia?o. – Ee?a; Aeiiaoeuee: Ee?i. o??o?a?y, 1998. – N. 157-158. 9. A?aaaithe A.?. E?eoaaiiy ai?eieo oieaia?o?a o ?aiiueiio i?neyiia?aoe?eiiio ia??iae? c aeei?enoaiiyi aeaeo?e/iiai iiey iino?eiiai no?oio // 2 I?aeia?iaeiee eiia?an nooaeaio?a ? iieiaeeo a/aieo (oace aeiiia?aeae). – Oa?iii?eue, 1998. – N. 261. 10. A?aaaithe A.?. Ci?ie eeneioii-eoaeii? ??aiiaaae aeia/? i?e e?eoaaii? ai?eiiai i?neyiia?aoe?eiiai oieaia?oo ca aeiiiiiaith aeaeo?e/iiai iiey iino?eiiai no?oio a aenia?eiaio? // Iao. 2-ai iaoeiaiai neiiiceoio "Aeieia?/i? i?iaeaie a o??o?a?? oa ?ioeo aaeocyo iaaeeoeeie". – *a?i?aoe?, 1998. – N. 31-32. 11. A?aaaithe A.?., Iaoe?ai?a A.A., I?aee?niee A.I. Aea/aiiy aeaeo?e/iiai iii?o oeaiei i?e ai?eiiio oieaia?o? oa ia/?ieia?e iaaeinoaoiino? a aenia?eiaioaeueieo oiiaao // Oai aea. – N. 33-34. 12. Grebeniuk V. Complex surgical treatment of purulent cholangitis on the background of gall-stone disease during the early post-operative period // 4-th International Medical Student's Congress (Poland). – Katowice, 1998. – P. 111. Aiioaoe?y A?aaaithe A.?. Canoinoaaiiy aeaeo?e/iiai iiey iino?eiiai no?oio a eiiieaeniiio e?eoaaii? ai?eieo oieaia?o?a oa oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino? a ?aiiueiio i?neyiia?aoe?eiiio ia??iae?. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ii niaoe?aeueiino? 14.01.03 - o??o?a?y. – Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y ?i. ?.ss.Ai?aa/aanueeiai, Oa?iii?eue, 1999. Aeena?oaoe?y i?enay/aia ieoaiiyi e?eoaaiiy aino?eo ai?eieo oieaia?o?a oa oieanoaoe/ii? ia/?ieiai? iaaeinoaoiino? o oai?eo ia aeia/ieaiyio oai?iao a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? c aeei?enoaiiyi ??cieo iaoiaeee aioo??oiueioeaieiiiai aeaeo?ioi?aco. Ia iniia? aenia?eiaioaeueieo aeine?aeaeaiue ia niaaeao iaaeaii i?e?ia?ieia?/ia iaa?oiooaaiiy iiceoeaii? ae?? aeaeo?e/iiai iiey iino?eiiai no?oio, aea/aia caeiiii??i?noue ci?i ieoiiiai aeaeo?e/iiai iii?o oa ?I aeia/?. ?ic?iaeaii oa ai?iaaaeaeaii a i?aeoeeo iia? iaoiaee e?eoaaiiy ai?eiiai oieaia?oo oa ia/?ieiai? iaaeinoaoiino?. I?e i?iaaaeaii? aiae?co ee?i?ei-eaai?aoi?ieo iieaciee?a aeaia ii??aiyeueia oa?aeoa?enoeea cai?iiiiiaaieo ? caaaeueiii?eeiyoeo iaoiae?a e?eoaaiiy. Eeth/ia? neiaa: ai?eiee oieaia?o, ia/?ieiaa iaaeinoaoi?noue, aeia/ieaiyia oai?iaa, aioo??oiueioeaieiiee aeaeo?ioi?ac, aeaeo?e/ia iiea iino?eiiai no?oio. Summary Grebeniuk W.I. The use of the electric field of constant current in complex treatment of purulent cholangitis and cholestatic liver insufficiency in the early post-operative stage. – Manuscript. Dissertation on competition scientific degree candidate of medical science in surgery 14.01.03. – Ternopil State Medical Academy named after I.Ya.Gorbachevsky, Ternopil, 1999. Dissertatiton dedicate for questions of treatment of purulent cholangitis and cholestatic liver insufficiency in the early post-operative period on the background of gall-stone disease. On the base of experimental examinations on the dogs was conduct microbiological basis positive result of influence the electric field of constant current by different density, was study the changes of specific electric resistance and pH of the bile. Were created and use in practice new methods of treatment of purulent cholangitis and cholestatic liver insufficiency. A comparative characteristic of proposed and conventional methods is presented on the basis of an analysis of clinicolaboratory data. Key words: purulent cholangitis, cholestatic liver insufficiency, gall-stone disease, inratissue electrophoresis, electric field of constant current. Aiiioaoeey A?aaaithe A.E. Eniieueciaaiea yeaeo?e/aneiai iiey iinoiyiiiai oiea a eiiieaeniii ea/aiee aiieiuo oieaiaeoia e oieanoaoe/aneie ia/?ii/iie iaaeinoaoi/iinoe a ?aiiai iineaiia?aoeeiiiii ia?eiaea. – ?oeiienue. Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.03 - oe?o?aey. – Oa?iiiieueneay ainoaea?noaaiiay iaaeeoeeineay aeaaeaiey ei. E.ss. Ai?aa/aaneiai, Oa?iiiieue, 1999. Aeenna?oaoeey iinayuaia aii?inai ea/aiey ino?uo aiieiuo oieaiaeoia e oieanoaoe/aneie ia/?ii/iie iaaeinoaoi/iinoe o aieueiuo aeae/iieaiaiiie aieaciueth a ?aiiai iineaiia?aoeeiiiii ia?eiaea n eniieueciaaieai ?acee/iuo iaoiaeee aioo?eoeaiaaiai yeaeo?ioi?aca. I?eciaiea i?ei?eoaoiie ?iee eioaeoeee a aicieeiiaaiee e ?acaeoee ainiaeeoaeueiuo caaieaaaiee aeae/aauaiaeyueo iooae i?eaaei e oe?ieiio eniieueciaaieth aioeaeioeeia. Ec-ca aaiiaeeiaie/aneeo e ii?oieiae/aneeo eciaiaiee a i/aaa ainiaeaiey i?ioeaiiee?iaiua i?aia?aou ia iiiaaeatho a ainiae?iiua oeaie aeeea?iie nenoaiu e a i/aiue iaaieueoie eiioeaio?aoeee auaeaeythony n aeae/ueth iai?iaeieaeeoaeueiia a?aiy. Iaeiei ec iooae auoiaea ec oaeiai iieiaeaiey yaeyaony eniieueciaaiea yeaeo?e/aneiai iiey iinoiyiiiai oiea (YIIO). A yenia?eiaioa ii?iaeecaoeey oaeaeueiiai yeaeo?e/aneiai nii?ioeaeaiey e ?I aeae/e iaaethaeaeanue ?aiueoa i?e ea/aiee ino?iai oieaiaeoa a neo/aa ?aniieiaeaiey iieiaeeoaeueiiai yeaeo?iaea a i?inaaoa ae?aiaaea oieaaeioa e eniieueciaaiey YIIO i?e ieioiinoe iiaea/e oiea ia aiia?aoa 1,5-2,8 iA/ni2. I?e ?acaeoee ia/?ii/iie iaaeinoaoi/iinoe a yenia?eiaioa iioeiaeueiui yaeyaony eniieueciaaiea YIIO n ieceie ieioiinoueth iiaea/e oiea ia aiia?aoa (0,7-1,4 iA/ni2). I?e yoii ieioiinoue i?ioiaeaeaiey oiea a oeaiyo ia i?aauoaea 0,1 iA/ni2. Enneaaeiaaiey oeceei-oeie/aneeo ia?aiao?ia aeae/e i?e aicaeaenoaee aioo?eoeaiaaiai yeaeo?ioi?aca a ?aiiai iineaiia?aoeeiiiii ia?eiaea o aieueiuo auyaeee eo ii?iaeecaoeeth ia 4-5 nooie ?aiueoa ii n?aaiaieth n eiio?ieueiie a?oiiie. I?e iee?iaeieiae/aneii enneaaeiaaiee aeae/e iee?ioei?a auaeaeaia a 96,8% neo/aaa. *aua anaai aunaaaeenue eeoa/iay iaei/ea e yioa?ieieee. Iee?ioei?a auea ?acenoaioiie eee iaei/oanoaeoaeueiie e aioeaeioeeai a 64,5% neo/aaa. I?e i?iaaaeaiee yeaeo?ioi?aca n eio?aoieaaeioaaeueiui ?aniieiaeaieai aeoeaiiai yeaeo?iaea iaaethaeaaony aieaa auno?ia oiaiueoaiea iee?iaiiai caa?yciaiey aeae/e. ?ac?aaioaiiua iaoiaeeee eniieueciaaiu i?e ea/aiee 52 aieueiuo, eioi?ui i?iaaaeaii a n?aaeiai 6-8 naainia aioo?eoeaiaaiai yeaeo?ioi?aca. O anao aieueiuo oa/aiea iineaiia?aoeeiiiiai ia?eiaea auei aeaaeeei. Eniieueciaaiea YIIO iicaieeei i?aaeioa?aoeoue eaoaeueiua enoiaeu a iiuoiie a?oiia aieueiuo (a eiio?ieueiie oia?ei 4), nieceoue eiee/anoai aiieii-naioe/aneeo ineiaeiaiee (a iiuoiie a?oiia - oieueei 2 ia?aie/aiiuo iiaa?oiinoiuo iaaiiaiey ?aiu a i?aaeaeao iiaeeiaeiie eeao/aoee) a ?aiiai iineaiia?aoeeiiiii ia?eiaea e nie?aoeoue iauee eieei-aeaiue n 24,941,16 aei 19,590,84 (p<0,01). O 17 aieueiuo n ia/aii/iie iaaeinoaoi/iinoueth ???-?V no. eniieueciaaiea i?aaeeiaeaiiuo iaoiaeee iicaieeei ainnoaiiaeoue ooieoeeth ia/aie ia 2-3 nooee iineaiia?aoeeiiiiai ia?eiaea, /oi i?iyaeeinue oaaee/aieai nae?aoeee aeae/e ii ae?aiaaeo a 2,2-2,6 ?aca e niinianoaiaaei eo/oaio i?ioaeaieth iineaiia?aoeeiiiiai ia?eiaea. Ia iniiaaiee yenia?eiaioaeueiuo enneaaeiaaiee i?iaaaeaii iee?iaeieiae/aneia iainiiaaiea iieiaeeoaeueiiai aeaenoaey YIIO, eco/aia caeiiiia?iinoue eciaiaiey oaeaeueiiai yeaeo?e/aneiai nii?ioeaeaiey e ?I aeae/e iiae aicaeaenoaeai YIIO ?acee/iie ieioiinoe. ?ac?aaioaiu e aiaae?aiu a i?aeoeeo iiaua niiniau ea/aiey aiieiuo oieaiaeoia e oieanoaoe/aneie ia/?ii/iie iaaeinoaoi/iinoe a ?aiiai iineaiia?aoeeiiiii ia?eiaea. Eeth/aaua neiaa: aiieiue oieaiaeo, ia/?ii/iay iaaeinoaoi/iinoue, aeae/iieaiaiiay aieaciue, aioo?eoeaiaaue yeaeo?ioi?ac, yeaeo?e/aneia iiea iinoiyiiiai oiea.

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