Вплив вірусів поліомієліту та їх бентонітових варіантів на пухлинні процеси в експерименті: Автореф. дис… канд. біол. наук / Н.В. Ахрамєєва, Нац. ме

I?i?noa?noai ioi?iie caei?ia’y Oe?a?ie

Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?iai? I.I.Aiaiiieueoey

Ao?ai??aa Iaoae?y Aieiaeeie??aia

OAeE 578.835.15:578.72:616-006-092.4

AIEEA A??ON?A IIE?II??E?OOOA ?O AAIOII?OIAEO AA??AIO?A IA IOOEEII?
I?IOeANE A AENIA?EIAIO?

03.00.06 — a??onieia?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa

a?ieia?/ieo iaoe

Ee?a — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao?

?iai? I.I.Aiaiiieueoey IIC Oe?a?ie.

Iaoeiaee ea??aiee: Oe?iaieia A.I., ae.i.i., i?ioani?, /eai-ei?. IAI oa
AII Oe?a?ie, caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie, caa?aeoth/ee
eaoaae?ith i?e?ia?ieia??, a??onieia?? oa ?ioiieia?? IIO.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani? ?eaaeei Na?oeaia
Eaiioue?aia, noa?oee iaoeiaee ni?a?ia?oiee, a. i. caa. eaai?aoi???th
i?e?ia?ieia?/iiai eiio?ieth yeino? ?ioiia?ieia?/ieo i?aia?ao?a
Ee?anueeiai iaoeiai-aeine?aeiiai ?inoeoooo ai?aeai?ieia?? oa
?ioaeoe?eieo oai?ia ?i. E.A.A?iiaoaanueeiai

aeieoi? iaaee/ieo iaoe, i?ioani? A?eiaae/ TH??e Aeeiiae/, caneoaeaiee
ae?y/ iaoee, caa?aeoth/ee aenia?eiaioaeueii-eaai?aoi?iei a?aeae?eii
?inoeoooo iieieia?? oa ?aae?ieia??

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe
?i. I.Ae.Ooieea IIC Oe?a?ie, i.Ee?a.

Caoeno a?aeaoaeaoueny “ 20 “ o?aaiy 1999 ?. i 13.30 ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.003.01 i?e Iaoe?iiaeueiiio
iaaee/iiio oi?aa?neoao? ?i. I.I.Aiaiiieueoey ca aae?anith: 252057,
Ee?a-57, i?iniaeo Ia?aiiae, 34, iaaeeei-i?io?eaeoe/iee ei?ion,
aoaeeoi??y ?2.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?i. I.I.Aiaiiieueoey ca aae?anith: Ee?a-57,
aoe.Ciieia?/ia,3.

Aaoi?aoa?ao ?ic?neaiee “ 20 ” ea?oiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

aeieoi? iaaee/ieo iaoe, i?ioani?
I.I. ssai?ianueeee

Aeooaeuei?noue ?iaioe

Iieieia?/i? caoai?thaaiiy yaeythoueny iaaecae/aeii aaaeeeaith iaaee/iith
oa nioe?aeueiith i?iaeaiith. Caaaeath/e ia oea, aenia?eiaioaeueia
iaa?oiooaaiiy iiaeo iaoiae?a oa?ai?? iooeei eeoa?oueny aeooaeueiei
caaaeaiiyi. A oaia??oi?e /an i?iaiaeeoueny ?ioaineaiee iiooe iiaeo
i?aeoiae?a aei e?eoaaiiy iieieia?/ieo caoai?thaaiue (A.A. Oeeiiaiei n
niaao., 1998; V Bertone et al.,1997; T Schunck et al, 1998). Iaeiei ?c
oaeeo iaoiae?a ? a??ioa?ai?y. Ieoaiiy i?i canoinoaaiiy a??on?a a
iieioa?ai?? aeine?aeaeo?oueny ? aeeneooo?oueny aaea i?ioyaii aeanyoe??/
— c iiiaioo a?aee?eooy yaeua a??oniiai iieio?ii?cio oa iieie?co.

Aea/aiiy aca?iiae?? a??on?a oa iooeei, ye iiaee iaoeiaee iai?yiie, ii/aa
oi?ioaaoeny a 50-o? ?iee. Aeey a??ioa?ai?? iieicaoai?thaaiue
aei?iaiaoaaeenue a??one ??cieo oaeniiii?/ieo a?oi oa a??oni? aaeoeeie —
a?aia??one, aaeaiia??one, a??one aa?iano, a??on a?niiaaeoeeie,
aioe?aa?/ia aaeoeeia c ??cieie, /anii noia?a/eeaeie, iane?aeeaie. Aea
niaeo? a??on?a, ui iiaeooue aooe aeei?enoai? a i?aeoe/i?e a??ioa?ai??,
iaiaaeo?oueny aeanoeainoyie oeeo a??on?a. Aiie iathoue aooe aiaoiaaiieie
/e iaeiiaoiaaiieie aeey ethaeeie ? ni?e/eiyoe ae?aaeaio ooii??ia?aoth/o
ae?th. C oe??? oi/ee ci?o ia?niaeoeaieie ? aioa?ia??one (AA), ye?
a?aeiinyoueny aei ?iaeeie Picornaviridae, ?iaeo Enterovirus (J.L.
Melnick, 1996). Ee?i?/io ai?iaaoe?th oa i?aeoe/ia canoinoaaiiy
aioa?ia??on?a a iieieia?/i?e ee?i?oe? ?icii/aea I.E.Ai?ioeeiaa (I.E.
Ai?ioeeiaa, 1986), yea noai?eea ?yae aeeaeo aioa?ia??onieo aaeoeei, ui
aeei?enoiaoaaeeny c 1958 ?ieo aeey ?ioi?caoe?? ?aeiaeo oai?eo c iaaiei
iiceoeaiei ee?i?/iei aoaeoii. Ia?aeaeueii c 1960 ?ieo Iooeai??oea A.ss.
?c ni?aaaoi?aie (A.ss. Iooeaieaoea, 1969; A.ss. Iooeaieaoea, 1977; A.ss.
Iooeaieaoea n niaao., 1982) i?iaiaeeee aenia?eiaioaeuei? aeine?aeaeaiiy
a oeueiio iai?yieo, a ?acoeueoao? yeeo aoei aeyaeaii iieio?ii?ci
cia/iiai /enea aioa?ia??on?a aei aeayeeo iooeei ethaeeie ? oaa?ei.

Na?aae AA iniaeeai ?aaeueiei aeey a??ioa?ai?? ? canoinoaaiiy aaeoeeiieo
ooai?a a??on?a iie?ii??e?oo (AAII), oiio, ui aiie ? neeaaeiaeie
eiiiiiaioaie aeeai? iie?ii??e?oii? aaeoeeie Naa?ia, yea
aeei?enoiao?oueny aeey ianiai? ?ioi?caoe?? ethaeae (oiaoi yaeythoueny
aacia/ieie), ?, ia?yaeo c ?ioeie aioa?ia??onaie, i?iyaeythoue iieio?iii?
aeanoeaino? (I.E Ai?ioeeiaa, 1979). C iaeyaeo ia oa, ui aca?iiae?y
a??on?a oa iooeei ia? aeoaea ?iaeea?aeoaeueiee oa?aeoa?, ia?aae oei ye
?aeiiaiaeoaaoe iaai? a??one aeey aeine?aeaeaiiy a iieieia?/i?e ee?i?oe?
iaiao?aeii ??ciia?/ii aea/eoe iaoai?cie ?o aieeao ia ?icaeoie iooeei oa
ia i?aai?ci a oe?eiio.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. A ?iaio?
ocaaaeueiaii ?acoeueoaoe aeine?aeaeaiue, cae?eniaieo ca?aeii c
aea?aeaaieie ieaiiaeie oaiaie IIC Oe?a?ie, a?aioiaeie aeine?aeaeaiiyie,
ye? aoee i?iaaaeai? ia eaoaae?? i?e?ia?ieia??. a??onieia??, ?ioiieia??
IIO i?e o?iainoaaii? IIC Oe?a?ie, Aea?aeaaiiai eii?oaoo ii ai?iouea? ?c
NI?Aeii :

Oaia: “Aieea aeeai? iie?ii??e?oii? aaeoeeie ia ?ioiio nenoaio”

? aea?aea?no?aoe?? 0194V025378.

Oaia: “?ioa?oa?aioe?y i?ae aioa?ia??onaie oa ?ao?ia??onaie ye iiaeeeaee
oeyo i?io?eaeoeee NI?Aeo oa NI?Ae-anioe?eiaaieo ?ioaeoe?e” ?
aea?aea?no?aoe?? 0195V0145.

Iaoith ?iaioe aoei aenia?eiaioaeueia aea/aiiy ?icaeoeo iooeei ?
i?ioean?a, ui ?o noi?iaiaeaeothoue, ia oii? aaaaeaiiy aaeoeeiieo
iie?ia??on?a oa aeine?aeaeaiiy iiaeeeaeo iaoai?ci?a iieiiiaeoethth/i?
ae?? inoaii?o.

Caaaeaiiy aeine?aeaeaiiy:

1. Aea/eoe aieea aaeoeeiieo iie?ia??on?a ia ?icaeoie iooeei ia
i?eeeaae?:

na?eiie 180 (S 180)

ai?aea?ii?aeii? ea?oeeiiie eaaaiue Eueth?na (LL)

a??on?iaeoeiaaiiai eaeeico ?aooa?a (LR)

2. Aeine?aeeoe aieea ia ?icaeoie aenia?eiaioaeueieo iooeei aaioii?oiaeo
aa??aio?a iie?ia??on?a ia i?eeeaae? AAII II oeio.

3. Aecia/eoe aieea aaeoeeiieo a??on?a iie?ii??e?oo ia aeaye? oaeoi?e
ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio ieoae:

i?iaeoeoe?th ?ioa?oa?iio

neioac oaeoi?o iae?ico iooeei

ooieoe?iiaeueio aeoeai?noue ii?iaeueieo e?ea??a

4. Aea/eoe oeueo?ano?oeoo?i? ci?ie a ee?oeiao e?noeiaiai iiceo o ieoae c
eaeeicii ?aooa?a oa a iooeeii?e oeaiei? oaa?ei c ai?aea?ii?aeiith
ea?oeeiiiith eaaaiue Eueth?na i?ae aieeaii aaeoeeiieo iie?ia??on?a

5. Ii??aiyeueii aeine?aeeoe ?ai?iaeoeoe?th aaeoeeiieo iie?ia??on?a a
i?aaiao oa iooeeiieo oeaieiao oaa?ei.

Iaoeiaa iiaecia ?iaioe.

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue aeyaeaii i?ioaeoeaiee
iieiiiaeoethth/ee aoaeo ?ioi?caoe?? aaeoeeiieie iie?ia??onaie ia
i?aai?ci oaa?ei c iiaiooai?aiiyie. C’yniaaii, ui aaaaeaiiy AAII III oeio
iaeae?aci?oa aieeaa? ia ?icaeoie eaeeico ?aooa?a oa ea?oeeiiie Eueth?na,
iaoiiaethth/e ca?eueoaiiy na?aaeiuei? o?eaaeino? aeeooy (NOAE) ieoae oa
ciaioaiiy na?aaeiuei? iane iooeei (NII) ? na?aaeiuei? e?eueeino?
iaoanoac?a. AAII II oeio iiceoeaii aieeaa? ia ieoae-iin??a na?eiie
S-180, iaoiiaeth? ca?eueoaiiy ?o NOAE oa ciaioaiiy iane iooeei.

Aia?oa i?iaaaeaii ii??aiyeueia aea/aiiy aieeao AAII ia ??ai? aeo?aeieo
iiioeyoe?e oa ?o aaioii?oiaeo aa??aio?a a?aeiinii ia?aa?ao aeanoiiieo
i?ioean?a. Ia i?eeeaae? AAII II oeio iieacaii, ui i?ioaeoeaiee aoaeo
?ioi?caoe?? aa??aioii Aaaio+ oaa?ei c S 180 oa LL aeuee, i?ae i?e
aeei?enoaii? a??on?a aeo?aeii? iiioeyoe??. Oea iiaea neoaeeoe
iaa?oiooaaiiyi noai?aiiy i?eioeeiiai iiaeo i?aia?ao?a ia iniia?
aaioii?oiaiai aa??aioo Aaaio+ iie?ia??on?a aeey canoinoaaiiy a oa?ai??
iooeei.

I?iaaaeaii eiiieaenio ioe?ieo ae?? AAII ia ?ioiieia?/i? iieacieee, ui
iia’ycai? c i?ioeiooeeiiei caoenoii. Anoaiiaeaii, ui aaeoeeii?
iie?ia??one i?aeaeuothoue ooieoe?iiaeueio aeoeai?noue ii?iaeueieo
e?ea??a, ?iaeoeothoue neioac ?ioa?oa?iio oa oaeoi?o iae?ico iooeei.

Oai?aoe/ia oa i?aeoe/ia cia/aiiy

I?iaaaeai? aeine?aeaeaiiy aeiiiaiththoue ? iiaeeaeththoue ?nioth/?
oyaeaiiy i?i aca?iiae?th a??on?a ? iooeei oiio ui:

eiiieaenia aea/aiiy aieeao AAII ia iooeeiiee i?ioean c aeei?enoaiiyi
a??onieia?/ieo, ?ioiieia?/ieo, aeaeo?iiiii?e?ineii?/ieo iaoiae?a oa
o?aaeeoe?eiiai i?aeoiaeo aei aecia/aiiy i?ioeiooeeiii? aeoeaiino?
a??onieo i?aia?ao?a iieacaei iayai?noue iieiiiaeoethth/eo aoaeo?a, i?iya
yeeo caeaaeeoue a?ae oeio ? aaioii?oiaiai aa??aioo a??on?a oa aeaeo
iooeeie;

iieiiiaeoethth/a ae?y AAII aeiaaaeaia ia eeoa ia ??ai? aeo?aeii?
a??onii? iiioeyoe??, a oaeiae ia ??ai? aaioii?oiaeo aa??aio?a — c
o?aooaaiiyi aeenioe?aoe?? aioa?ia??on?a ia aa??aioe Aaaio+ oa Aaaio
SYMBOL 45 \f «Symbol» \s 13.5 — a i?ioean? ?ai?iaeoeoe??. Ia i?eeeaae?
AAII II oeio aeiaaaeaii, ui aa??aio Aaaio+ (aeii?ioth/ee eiiiiiaio
iiioeyoe??) ia? a?eueo ae?aaeaiee i?ioaeoeaiee aoaeo, i?ae a??one
aeo?aeii? iiioeyoe??. Aa??aio Aaaio SYMBOL 45 \f «Symbol» \s 13.5 —
(i?ii?iee eiiiiiaio iiioeyoe?? aaeoeeiieo ooai?a iie?ia??on?a), iaaiaee,
coiiaeth? a?eueo ?ioaineaiee ??no iooeei.

?ic?iaeaia noaia eiiieaenii? aenia?eiaioaeueii? ioe?iee aieeao a??on?a
ia ?icaeoie iooeei, yeo iiaeia ?aeiiaiaeoaaoe aeey i?iaaaeaiiy
aiaeia?/ieo aeine?aeaeaiue a ee?i?/ieo oiiaao.

Io?eiai? ?acoeueoaoe aeiaiaeyoue, ui AAII yaeythoueny ia?niaeoeaieie
aeey iiaeaeueoiai aea/aiiy ?o oa?aiaaoe/ieo iiaeeeainoae a iieieia?/i?e
ee?i?oe?.

Iniaenoee aianie caeiaoaa/a. Aenia?eiaioaeueia aea/aiiy aieeao
iie?ia??on?a oa ?o aaioii?oiaeo aa??aio?a ia ?icaeoie iooeei,
aeine?aeaeaiiy oaeoi??a ianiaoeeo?/ii-ai caoenoo oaa?ei ia oii?
?ioi?caoe?? oa oaa?ei c iooeeiaie, aeyaeaiiy ?iciiiaeaiiy iie?ia??on?a a
oeaieiao oa i?aaiao ieoae c aeei?enoaiiyi iaoiaeo oioinainea?e?caoe??
a??on?a cae?eniai? aaciina?aaeiuei aaoi?ii ?iaioe ia eaoaae??
i?e?ia?ieia??, a??onieia?? oa ?ioiieia?? IIO. Aeine?aeaeaiiy
oeueo?ano?oeoo?e iooeeiieo ee?oei oa ee?oei e?no-eiaiai iiceo i?iaaaeai?
a eaai?aoi??? aeaeo?iiii? i?e?ineii?? OeIAeE IIO, eiinoeue-oaoe?? oa
aeiiiiiao iaaeaaaea i?io. Noa/aiei E.I., ca ui aeneiaeth?ii ?e ue?o
iiaeyeo.

Ai?iaaoe?y ?iaioe.

Iniiai? iieiaeaiiy ?iaioe aoee aeeeaaeai? ia 10-io i?aeia?iaeiiio
eiia?an? c a??onieia?? (Jerusalem, Israel, 1996), i?aeia?iaei?e iaoeia?e
eiioa?aioe??, i?enay/ai?e 150-??//th c aeiy ia?iaeaeaiiy Ia/ieeiaa (i.
Oa?e?a, 1995), i?aeia?iaei?e iaoeia?e eiioa?aioe?? “Ii?oieia?y —
i?aeoe/i?e aaoa?eia??? oa iaaeeoeei?” (i. A?ea Oea?eaa, 1998),
eiioa?aioe??, i?enay/ai?e 100-??//th a?ae aeiy ia?iaeaeaiiy N.N.Aey/aiea
(i. Ee?a, 1998).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 13 ?ia?o, a oiio /ene?
7 noaoae, i?aaenoaaeaieo o aeaeaiiyo, ?aeiiaiaeiaaieo AAE Oe?a?ie.

No?oeoo?a oa ianya ?iaioe. Iniiaiee iaoa??ae aeena?oaoe?? aeeeaaeaii ia
169 noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny ?c anooio, iaeyaeo
e?oa?aoo?e, 4 ?icae?e?a aeanieo aeine?aeaeaiue, aeniiae?a, nieneo
aeei?enoaieo aeaea?ae (186 a?o/eciyieo oa 96 ?iicaiieo). Aeena?oaoe?eia
?iaioa ?ethno?iaaia 16 oaaeeoeyie oa 12 iaethieaie.

Iniiaiee ci?no aeena?oaoe??.

Iaoa??aee oa iaoiaee aeine?aeaeaiue.

Aeey i?iaaaeaiiy aeine?aeaeaiue aoee aeei?enoai? ae?iaie/? aaeoeeii?
ooaie a??on?a iie?ii??e?oo ? — LSn2ab, ?? — P-712,ch 2ab oa ??? — Leon12
ab oei?a, io?eiai? c ?inoeoooo iie?ii??e?oo oa a??onieo aioeaoae?o?a AII
N?N? a 1983 ?ioe?.

Aea/aiiy iieiiiaeoethth/i? ae?? oeeo a??on?a i?iaiaeeee ia oaeeo
aenia?eiaioaeueieo iooeeiieo iiaeaeyo: na?eiia 180, ai?aea?ii?aeia
ea?oeeiiia eaaaiue Eueth?na oa a??on?iaeoeiaaiee eaeeic ?aooa?a, ye?
aoee etha’ycii iaaeai? no.i.n. E.?. Caai?oeei oa i?io. I.?. Iaoiaiei
(?inoeooo ?aae?ieia?? oa aenia?eiaioaeueii? iieieia?? ?i.
?.Eaaaoeueeiai). Ia?auaieaiiy iooeei oa aea/aiiy aieeao a??on?a ia
?icaeoie aeanoii i?iaiaeeee ca eeane/ieie iaoiaeeeaie, ui
aeei?enoiaothoueny aeey aeine?aeaeaiiy i?ioeiooeeiieo i?aia?ao?a
(A.Aooane n niaao., 1980). Aenia?eiaioe aeey aea/aiiy aieeao
iie?ia??on?a ia ?icaeoie iooeei i?iaiaeeee ca oaeith caaaeueiith
noaiith: cae?enithaaee iiia?aaeith ?ioi?caoe?th oaa?ei a??onai?niei
iaoa??aeii, /a?ac 2 aeiae i?euaiethaaee iooeeie, a i?ioean? ?icaeoeo
aeanoiie i?iaiaeeee iiaoi?io ?ioi?caoe?th a?aeiia?aeieie a??onaie.
?acoeueoaoe ioe?ithaaee ca na?aaeiueith ianith iooeei (aeey oeueiai
ieoae caaeaaee oa aeeo/aee iooeeie) oa na?aaeiueith o?eaae?noth aeeooy
oaa?ei. Ia iiaeae? ea?oeeiiie Eueth?na aecia/aee e?euee?noue iaoanoac?a.

Aeey aeine?aeaeaiiy iieiiiaeoethth/iai aoaeoo a??on?a iie?ii??e?oo ia
??ai? iiioeyoe?? iiia?aaeiuei io?eioaaee aaioii?oia? aa??aioe Aaaio+ oa
Aaaio SYMBOL 45 \f «Symbol» \s 13.5 — , ia ye? aeenioe?ththoue
aioa?ia??one a i?ioean? ?ai?iaeoeoe??. Aeey naeaeoe?? aaioii?oiaeo
aa??aio?a ?c iiioeyoe?e a??on?a aoei canoiniaaii niaoe?aeueiee iaoiae
(A.I. Oe?iaieia, 1977). Eiai i?eioeei iieyaa? a oiio, ui aeii?ioth/a
/anoeia iiioeyoe?? iie?ia??on?a aaeni?ao?oueny ia aaioii?o? i?e
iaeo?aeueieo aai neaaieoaeieo ?I, oiio oeae aa??aio iaea?aeaa neiaie
Aaaio +. I?ii?ia /anoeia iiioeyoe?? — oea a??one, ye? ia aaeni?aothoueny
ia aaioii?o? i?e aeaieo ?I. Aiie io?eiaee iacao aa??aio Aaaio SYMBOL 45
\f «Symbol» \s 13.5 — . Aeey naeaeoe?? aeei?enoiaoaaee 0,5% noniaic?th
aaeth aaioii?oo, yeee aeiaeaaaee aei a??onai?niiai iaoa??aeo (?I
7,2-7,6). Aai-oii?o c aaeni?aiaaieie a??onaie iaaeae? aeei?enoiaoaaee ye
aeaea?aei aa??aioo Aaaio+, a noia?iaoaio i?aeaeaaaany ua 6 aeniaaeaiiyi
aaeai aaioii?oo ? i?noea aa??aio Aaaio SYMBOL 45 \f «Symbol» \s 13.5 — .
Iio?i i?iaiaeeee ianaae? a??on?a iaio aa??aio?a ia ee?oeiieo eoeueoo?ao.
Io?eiaiee a?-?onai?niee iaoa??ae iiaoi?ii ia?iaeyee aaioii?oii i?e ?I
7,2-7,6 ? eiioeaio?oaaee.

Iiaeeeaeie iaoai?ciaie aieeao a??on?a ia ia?aa?a aeanoiiieo i?ioean?a ?
i?yiee iieie?c, iaoiiaeaiee iieio?ii?ciii ? ?iciiiaeaiiyi a??on?a a
iooeeii?e oeaiei?, a oaeiae a??on?iaeoeiaaia ?ioiiiiaeoeyoe?y.

C iaoith iaea?aeaiiy aeieac?a ?ai?iaeoeoe?? iie?ia??on?a a iooeeiao oa
?ioeo i?aa-iao oaa?ei aoa aeei?enoaiee oaiiiai oioinainea?e?caoe??
aioa?ia??on?a i?ioeaa?iii (A.A. Ei?ieaaa, 1980). Aeneiaeth?ii ue?o
iiaeyeo i?io. A.A.Ei?ieueia?e ca eiinoeue-oaoe?? oa iaaeaiiy i?aia?aoo
i?ioeaa?io. Ia?iaeai? i?ioeaa?iii a??one iaaoaathoue aea-noea?noue
?iaeoeaoaaoeny i?ae ae??th na?oea. Oea ia aaiaoe/iee oaiiiai, oiio ia
a??onia iioiinoai a?i ia ?iciianthaeaeo?oueny. Iiioeyoe?th a??on?a
ia?aae ?ioi?caoe??th ia?iaeythoue i?ioeaa?iii. A i?ioean? ?ai?iaeoeoe??
a i?aai?ci? oaa?ei iauaaeee ia?iaeaieo i?ioeaa?iii a??on?a ao?a/athoue
oioi/ooeea?noue. I?ney aeae?eaiiy c i?aai?a /anoeio iaoa??aeo ia?iaeyee
na?oeii ? i?iaiaeeee ii??aiyeueia oeo?oaaiiy. Aeyaeaiiy ?ioaeoe?eieo
a??on?a a /anoei? AAAI, ui aoea ia?iaeaia na?oeii, na?ae/eoue i?i
?ai?iaeoeoe?th aioa?ia??on?a a i?aaiao oaa?ei. Aeyaeaiiy ?ioaeoe?eieo
a??on?a o?eueee a /anoei? iaoa??aeo, ia ia?iaeai?e na?oeii, na?ae/eoue
i?i oa, ui oea a??one aeo?aeii? iiioeyoe??, oiaoi a??one, ye? eeoa
i?iieeaee a oeaieie, aea ia ?iciiiaeoaaeeny a ieo. Aeey i?iaaaeaiiy
aenia?eiaioo oaa?eiai-iooeeiiiin?yi aaiaeeee ia?iaeai? i?ioeaa?iii
a??one. Aeae?eaiiy a??on?a i?iaiaeeee /a?ac 48 aiaeei i?ney ?ioi?caoe??.

C iaeyaeo ia oa, ui iniiaio ?ieue a i?ioeiooeeiiiio caoeno?
a?ae?a?athoue ianiaoeeo?/i? oaeoi?e, aoei aeine?aeaeaii aieea
?ioi?caoe?? aaeoeeiieie iie?ia??onaie ?ioaeoieo ieoae oa
oaa?ei-iooeeiiiin??a ia oae? iieacieee ye ooieoe?iiaeueia aeoeai?noue
ii?iaeueieo e?ea??a (IE), neioac oaeoi?o iae?ico iooeei (OII) oa
?ioa?oa?iio (?OI). Aeey oeueiai ?ioaeoiei oaa?eiai aaiaeeee a??one
a?aeiia?aeiiai oeio a e?eueeino? 1o107 OOeAe50. *a?ac 1, 4, 7 oa 14 ae?a
i?ney ?ioi?caoe?? oaa?ei caaeaaee, a?aee e?ia oa naeac?iee aeey
iiaeaeueoeo aeine?aeaeaiue. C iaoith aea/aiiy aieeao iie?ia??on?a ia
?aaeoeai?noue iooeeiiiin??a oaa?ei ?ioi?coaaee, /a?ac 24 aiaeeie ?i
i?euaiethaaee iooeeie. Acyooy iaoa??aeo aeey aeine?aeaeaiue
cae?enithaaee /a?ac 14 ae?a i?ney ?iieoeyoe?? iooeeiieo ee?oei (LL oa S
180) /e /a?ac 22 aeiae i?ney aaaaeaiiy a??ono eaeeico ?aooa?a (VLR).

Aecia/aiiy aeoeaiino? ii?iaeueieo e?ea??a i?iaiaeeee eiei?eiao?e/iei
iaoiaeii (I.A. Eociaeiaa, 1991). Aeey oeueiai aeei?enoiaoaaee
nieaiioeeoe ieoae, ye? i?iyaeythoue aeoeai?noue ii?iaeueieo e?ea??a.
Oeth aeoeai?noue aeyaeyee ii oeeoioiene/i?e ae?? ia /ooeea? ee?oeie
L-929. Ioe?ieo oeeoie?co i?iaiaeeee c aeei?enoaiiyi a?oaeueiiai
aa?aieea, yeee aiineee a eoeueoo?o ee?oei-i?oaiae aei ia?iaee ?o IE.
I?ney ?oeioaaiiy /anoeie ee?oei i?ae ae??th NK c ieo aea?eueiy?oueny
aa?aiee. Iaoiaeii niaeo?ioioiiao??? aecia/aee ?ioaineai?noue caaa?aeaiiy
eoeueoo?aeueii? ??aeeie aeine?aeieo oa eiio?ieueieo i?ia (ia ia?iaeaieo
nieaiioeeoaie) ? ioe?ithaaee oeeoioiene/iee ?iaeaen.

Aecia/aiiy ??aiy OII a ieaci? e?ia? iniiaaia ia aeyaeaii? oeeoie?oe/ii?
ae?? OII ii a?aeiioaiith aei /ooeeaeo ee?oei L-929. Aeey oeueiai
ee?oeiio noniaic?th ?iceeaaee a 96-eoieia? ieaioaoe ? i?ney 24 aiaeei
?ieoaaoe?? aeiaeaaaee aeoeiii?oeei oa aeine?aei? ne?iaaoee. *a?ac 24
aiaeeie ?ieoaaoe?? a NI2-?ieoaaoi??, ceeaaee na?aaeiaeua, ui i?noeei
c?oeiiaai? i?ae ae??th OII ee?oeie, ? aeiaeaaaee 0,2% ?ic/ei
e??noae-a?ieaoo aeey caaa?aeaiiy ee?oei, ui caeeoeeeny a eoieao. Ia
niaeo?ioioiiao?? aecia/aee ?ioaineai?noue caaa?aeaiiy oa i?ae?aoiaoaaee
oeeoioiene/iee ?iaeaen.

Aeey aecia/aiiy ?ioa?oa?iio aoei aeei?enoaii 2 i?aeoiaee: aeyaeaiiy
ne?iaao-eiaiai ?OI, ?iaeoeiaaiiai iie?ia??onaie oa iooeeiaie ? aeyaeaiiy
?OI, neioaciaaii-ai nieaiioeeoaie i?ae ae??th ?iaeoeoi??a (eiieaiaaae?io
A — SYMBOL 103 \f «Symbol» \s 14 g -?OI oa a??ono oai?iae Iueth-eanea —
SYMBOL 97 \f «Symbol» \s 14 a -?OI). I?eioeei iaoiaeo iieyaa? a oiio,
ui ?OI ni?aaey? i?ioaeoeaio ae?th ii a?aeiioaiith aei ee?oei,
?io?eiaaieo a??onaie. Oeae aoaeo ioe?iththoue ii iaeo?ae?caoe?? OeIA
i?i?ioi ia 50%. Aeey aecia/aiiy ?OI ieoae canoiniaoaaee
caaaeueiii?eeiyoo nenoaio: eoeueoo?a ee?oei L-929 oa a??on aac?eoey?iiai
noiiaoeoo. Ue?i aeyeo?ii a. i.n. eaa. i?e?ia?ieia?? oa a??onieia?? IAe?
ioiei??iaieia?? ?i.I.?.Eieiiee/aiea, E?eaioaonuee?e E.Ae. ca etha’ycia
iaaeaiiy iaiao?aeieo ?aaeoea?a oa eiinoeueoaoeaio aeiiiiiao.

Aeey aeaeo?iiii-i?e?ineii?/ieo aeine?aeaeaiue oeueo?ano?oeoo?e iooeeiieo
ee?oei ieoae aeei?enoiaoaaee eeane/io iaoiaeeeo i?eaiooaaiiy
aeaeo?iiiii?e?ineii?/ieo i?aia?ao?a. Iaoa??ae o?enoaaee o ?ic/ei? OsO4
ii Eieo?eueaeo. C?acee ciaaiaeithaaee a aoaiie? c?inoath/i?
eiioeaio?aoe??, ii/eiath/e c 700 nie?oo, aoeaoiio oa caeeaaee o noi?o
aiiio oa a?aeae?oo ca caaaeueiia?aeiiith noaiith (A.ss.Ea?oio, 1984).
C??ce aeaioiaeyee ia oeueo?aoiiao LKB-O oa Reichert ? eiio?anooaaee 2%
?ic/eiii o?ai?eaoeaoaoo o 70% aoaiie? oa oeeo?aoii naeioey oa aea/aee a
aeaeo?iiieo i?e?ineiiao AIA-100A, AIA-100A?. Ioe?ieo ci?i
ii?oiooieoe?iiaeueii? i?aai?caoe?? ee?oei i?iaiaeeee ca?aeii iaoiaeai
(A.I.Ni?ieei, 1989; R.Duke et al., 1996; S.Bergese et al., 1997).

Io?eiai? aenia?eiaioaeuei? aeai? ia?iaeyee iaoiaeii aa??aoe?eii?
noaoenoeee c aecia/aiiyi e?eoa??th No’thaeaioa (Ieioea? I.I., 1982).

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy.

I?e aea/aii? iieiiiaeoethth/i? aeoeaiino? aaeoeeiieo a??on?a
iie?ii??e?oo anoaiiaeaii, ui an? 3 oeie a??on?a caeaoi? aieeaaoe ia
?icaeoie aenia?eiaioaeueieo iooeei. Oa?aeoa? oa ?ioaineai?noue ae??
caeaaeeoue ye a?ae oeio a??ono, oae ? a?ae aeaeo iooeeie.

Aeine?aeaeaiiy, i?iaaaeai? ia iiaeae? na?eiie 180 a?aeia?aaeai? a oaae.
1.

Oaaeeoey 1.

Aieea aaeoeeiieo iie?ia??on?a ia ?icaeoie na?eiie 180 o ieoae.

A??one Na?aaeiy iana iooeeie Na?aaeiy o?eaae?noue aeeooy

aaniethoia

(M SYMBOL 177 \f «Times New Roman» \s 14 ± m, a) a?aeiinii eiio?ieth

(a %)

aaniethoia

(a aeiaao) a?aeiinii eiio?ieth

(a %)

aac ?ioi?caoe??

(n=10) 4,42 SYMBOL 177 \f «Symbol» \s 14 ± 0,53 100 17,79 SYMBOL 177
\f «Symbol» \s 14 ± 0,11 100

I oei (n=10) 5,57 SYMBOL 177 \f «Symbol» \s 14 ± 0,56

? SYMBOL 62 \f «Symbol» \s 13.5 > 0,1 126 18,48 SYMBOL 177 \f «Symbol»
\s 14 ± 0,07

? SYMBOL 62 \f «Symbol» \s 13.5 > 0,1 103

II oei, (n=10) 2,21 SYMBOL 177 \f «Symbol» \s 14 ± 0,35

? SYMBOL 60 \f «Symbol» \s 13.5 < 0,02 50 25,84 SYMBOL 177 \f "Symbol" \s 14 ± 0,72 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,05 144 III oei, (n=10) 2,68 SYMBOL 177 \f "Symbol" \s 14 ± 0,25 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,02 60,6 18,02 SYMBOL 177 \f "Symbol" \s 14 ± 1,21 ? SYMBOL 62 \f "Symbol" \s 13.5 > 0,1 100,7

I?ei?oea: P- ??aaiue cia/ouino? ii a?aeiioaiith aei eiio?ieueii? a?oie
(ia?ioi?ciaai? oaa?eie).

Iaea?eueoee aieea ia ?icaeoie iooeeie ni?e/eiy? AAII II oeio,
?ioi?caoe?y yeei aeeeeea? cao?eieo ?inoo na?eiie, i?iaeiaaeo?
o?eaae?noue aeeooy oaa?ei ia 44% ? ciaioo? iano iooeei a na?aaeiueiio a
2 ?ace ii??aiyii c eiio?ieueiith a?oiith. AAII III oeio ni?ey?
ciaioaiith na?aaeiuei? iane iooeei a 1,65 ?ace, aea ia aieeaa? ia NOAE.
Ae?y AAII I oeio a?ae??ciy?oueny oei, ui a?i ia eeoa ia aieeaa? ia
o?eaae?noue aeeooy ieoae, a iaa?oue ni?ey? i?enei?aiith ?inoo iooeeie oa
iaoiiaeth? ca?eueoaiiy ?? iane ia 26 % ii??aiyii c eiio?ieai.

Aieea aaeoeeiieo a??on?a iie?ii??e?oo ia ia?aa?a ea?oeeiiie Eueth?na
i?aaenoaaeaiee a oaae. 2.

Oaaeeoey 2.

Aieea aaeoeeiieo iie?ia??on?a ia ?icaeoie ea?oeeiiie Eueth?na o ieoae

A??one Na?aaeiy iana

iooeei Na?aaeiy e?euee?noue iaoanoac?a Na?aaeiy o?eaae?noue aeeooy

aaniethoia

(M SYMBOL 177 \f «Symbol» \s 14 ± m, a) a?aeiinii eiio?ieth

(a %) aaniethoia a?aeiinii eiio?ieth

(a %) aaniethoia

(a aeiaao) a?aeiinii eiio?ieth

(a %)

aac ?ioi?caoe??

(n=10) 2,03 SYMBOL 177 \f «Symbol» \s 14 ± 0,18 100 1,88 SYMBOL 177 \f
«Symbol» \s 14 ± 0,49 100 29,1 SYMBOL 177 \f «Symbol» \s 14 ± 0,92
100

? oei

(n=10) 1,66 SYMBOL 177 \f «Symbol» \s 14 ± 0,31

? SYMBOL 62 \f «Symbol» \s 13.5 > 0,1 81,8 2,88 SYMBOL 177 \f «Symbol»
\s 14 ± 0,62

? SYMBOL 60 \f «Symbol» \s 13.5 < 0,05 153 27,2 SYMBOL 177 \f "Symbol" \s 14 ± 1,9 ? SYMBOL 62 \f "Symbol" \s 13.5 > 0,1 93,5

?? oei

(n=10) 1,36 SYMBOL 177 \f «Symbol» \s 14 ± 0,24

? SYMBOL 60 \f «Symbol» \s 13.5 < 0,05 67 1,44 SYMBOL 177 \f "Symbol" \s 14 ± 0,33 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,05 76,6 33,7 SYMBOL 177 \f "Symbol" \s 14 ± 0,56 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,02 115,8 ??? oei (n=10) 1,16 SYMBOL 177 \f "Symbol" \s 14 ± 0,28 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,02 57,1 1,2 SYMBOL 177 \f "Symbol" \s 14 ± 0,318 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,05 63,8 36,8 SYMBOL 177 \f "Symbol" \s 14 ± 0,34 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,01 126,5 I?ei?oea: P - ??aaiue cia/ouino? ii a?aeiioaiith aei eiio?ieueii? a?oie (ia?ioi?ciaai? oaa?eie). Iaeae?aci?oee aoaeo ni?e/eiy? AAII III oeio - Leon,12ab, ?ioi?caoe?y yeei iaoiiaeth? ciaioaiiy na?aaeiuei? iane iooeeie ia 42,9 %, ca?eueoaiiy na?aaeiuei? o?eaa-eino? aeeooy oaa?ei ia 26,5 % ? ciaioaiiy e?eueeino? iaoanoac?a ia 36,2 % ii??aiyii c eiio?ieai. ?ioi?caoe?y ieoae AAII ?? oeio - P-712,ch 2ab oaae iaoiiaeth? aioeaean-oiiio aeoeai?noue ii a?aeiioaiith aei ea?oeeiiie ? aeeeeea? cieaeaiiy na?aaeiuei? iane iooeeie ia 33%, i?iaeiaaeo? na?aaeith o?eaae?noue aeeooy ieoae-iooeeiiiin??a ia 15,8 % ? cieaeaiiy /enea iaoanoac?a ia 23,4 %. Aaeoeeiiee iie?ia??on I oeio - LSc,2ab iaeaea ia aieeaa? ia ??no iooeeie LL, aea i?ecaiaeeoue aei aeoeaaoe?? i?ioeano iaoanoacoaaiiy a 1,53 ?ace.Ianiiae?aaiee aoaeo ni?e/eiy? ?ioi?caoe?y aeine?aeieo oaa?ei anioe?aoe??th o?ueio oei?a iie?ia??on?a. Oaeee a??oniee i?aia?ao iaeaea ia aieeaa? ia iano iooeei ieoae, aea eiai noi?aneaia ae?y ia i?aai?ci iooeeiiiin??a i?iyaey?oueny a i?aeneeai?e ?iaeoeoe?? i?ioeano iaoanoacoaaiiy - e?euee?noue iaoanoac?a aeey oaeeo oaa?ei noaiiaeoue a na?aaeiuei-io 6,5 iaeeieoeue, ui a 3,46 ?ac?a ia?aaeuo? aiaeia?/iee iieaciee a eiio?ieuei?e a?oi?. Ae?th iie?ia??on?a ia ?icaeoie eaeeic?a aoei aeine?aeaeaii ia iiaeae? a??on?iaeoeiaaiiai eaeeico ?aooa?a – oaae.3. Oaaeeoey 3. Aieea aaeoeeiieo iie?ia??on?a ia na?aaeith o?eaae?noue aeeooy ieoae c eaeeicii ?aooa?a A??one Aaniethoia na?aaeiy o?e-aae?noue aeeooy (a aeiaao) Na?aaeiy o?eaae?noue aeeooy a?aeiinii eiio?ieth (a %) aac ?ioi?caoe?? (n=15) 16,94 SYMBOL 177 \f "Symbol" \s 14 ± 4,32 100 ? oei (n=15) 35,71 SYMBOL 177 \f "Symbol" \s 14 ± 2,99 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,01 210,8 ?? oei (n=15) 26,04 SYMBOL 177 \f "Symbol" \s 14 ± 1,24 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,05 153,7 ??? oei (n=15) 144,93 SYMBOL 177 \f "Symbol" \s 14 ± 3,29 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 855,5 I?ei?oea: P- ??aaiue cia/ouino? ii a?aeiioaiith aei eiio?ieueii? a?oie (ia?ioi?ciaai? oaa?eie). Aiae?c iaea?aeaieo ?acoeueoao?a iieaco?, ui ?ioi?caoe?y ieoae AAII I oeio iaoiiaeth? ca?eueoaiiy NOAE ia 110,8% ii??aiyii c eiio?ieueiith ia?ioi?ciaaiith a?oiith. AAII II oeio aeeeeea? aeaui iaioee aoaeo - NOAE ca?eueoo?oueny ia 53,7%. Iaeae?aci?oo i?ioeiooeeiio aeoeai?noue ia? AAII III oeio. NOAE oaa?ei, yeei aaiaeeee oeae a??on, ca?eueooaaeany ia 755,5% ? neeaaeaea 144,9 aei?a. Aaioii?oia? aa??aioe ca aieeaii ia iooeeii? i?ioeane i?eioeeiiai a?ae??ciythoueny iaeei a?ae iaeiiai, i?i ui na?ae/aoue ?acoeueoaoe, i?aaenoaaeai? a oaae.4. Oaaeeoey 4. Aieea aaiaoe/ieo aa??aio?a aaeoeeiiiai iie?ia??ono ?? oeio ia ?icaeoie aenia?eiaioaeueieo iooeei A??one Na?eiia 180 Ea?oeeiiia Eueth?na na?aaeiy iana iooeei na?aaeiy iana iooeei na?aaeiy e?euee?noue iaoanoac?a aaniethoia (M SYMBOL 177 \f "Symbol" \s 14 ± m, a) a?aeiinii eiio?. (a %) aaniethoia (M SYMBOL 177 \f "Symbol" \s 14 ± m, a) a?aeiinii eiio?. (a %) aaniethoia a?aeiinii eiio?. (a %) aac ?ioi?caoe?? (n=15) 3,2 SYMBOL 177 \f "Symbol" \s 14 ± 0,16 100 3,67 SYMBOL 177 \f "Symbol" \s 14 ± 0,17 100 2,4 SYMBOL 177 \f "Symbol" \s 14 ± 0,51 100 aeo?aeia iiioeyoe?y (n=15) 1,46 SYMBOL 177 \f "Symbol" \s 14 ± 0,11 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 45,6 2,86 SYMBOL 177 \f "Symbol" \s 14 ± 0,19 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,01 77,9 1,6 SYMBOL 177 \f "Symbol" \s 14 ± 0,3 ? SYMBOL 60 \f "Symbol" \s 13.5 < 0,1 66,7 aa??aio Aaaio+ (n=15) 0,9 SYMBOL 177 \f "Symbol" \s 14 ± 0,16 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 ?2 SYMBOL 60 \f "Symbol" \s 13.5 < 0,02 28,1 2,03 SYMBOL 177 \f "Symbol" \s 14 ± 0,11 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 ?2 SYMBOL 60 \f "Symbol" \s 13.5 < 0,01 55,3 0,7 SYMBOL 177 \f "Symbol" \s 14 ± 0,21 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,02 ?2 SYMBOL 60 \f "Symbol" \s 13.5 < 0,05 29,2 aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - (n=15) 6,9 SYMBOL 177 \f "Symbol" \s 14 ± 0,17 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 ?2 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 215,6 5,43 SYMBOL 177 \f "Symbol" \s 14 ± 0,25 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 ?2 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 147,9 4,9 SYMBOL 177 \f "Symbol" \s 14 ± 0,32 ?1 SYMBOL 60 \f "Symbol" \s 13.5 < 0,01 ?2 SYMBOL 60 \f "Symbol" \s 13.5 < 0,001 204,1 I?ei?oea: P1- ??aaiue cia/ouino? ii a?aeiioaiith aei eiio?ieueii? a?oie (ia?ioi?ciaai? oaa?eie), P2 – ??aaiue cia/ouino? ii a?aeiioaiith oaa?ei, ?ioi?ciaaieo a??onaie aeo?aeii? iiioeyoe?? (a iaaeao iooeeiii? iiaeae?). O ieoae, yeeo ?ioi?coaaee aa??aioii Aaaio+, na?aaeiy iana na?eiie aoea a 3,6 ?ace ieae/ith i?ae a eiio?ieuei?e a?oi? oa a 1,6 ?ace iaioith, i?ae o oaa?ei, yeei aaiaeeee a??one aeo?aeii? aaoa?iaaiii? iiioeyoe??. Aiaeia?/i? iieacieee aoee io?eiai? ? ia iiaeae? ea?oeeiiie Eueth?na. Aa??aio Aaaio+ coiiaethaaa cieaeaiiy na?aaeiuei? iane iooeeie iaeaea a 2 ?ace ? ciaioaiiy iaoanoac?a o 3,43 ?ace ii??aiyii c eiio?ieueieie oaa?eiaie. Oaa?eie c na?eiiith 180, ye? iaea?aeaee aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - , iaee iooeeie a 2,16 ?ace a?eueo? ca eiio?ieuei?. Ii??aiyii c na?aaeiueith ianith iooeei ieoae, ?ioi?ciaaieo aeo?aeiei a??onii ? aa??aioii Aaaio+ , oeae iieaciee ca?eueooaaany a 4,6 ? 7,5 ?ace a?aeiia?aeii. Iiae?aia oaiaeaioe?y niinoa??aa?oueny ? i?e aeine?aeaeaiiyo ia ieoao c ea?oeeiiiith. Oae, aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - coiiaeth? i?aeaeuaiiy o ieoae na?aaeiuei? iane iooeeie ia 47,9% ii??aiyii c eiio?ieai ? ia 89,8% o ii??aiyii? c oaa?eiaie, ?ioi?ciaaieie a??onaie aeo?aeii? iiioeyoe??. E?euee?noue iaoanoac?a o oaa?ei, ui io?eiaee aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - , ia?aaeuo? oaeiae aiaeia?/iee iieaciee o eiio?ieueieo oaa?ei oa ieoae, ?ioi?ciaaieo aeo?aeiith iiioeyoe??th, a 2,04 oa 3,1 ?ace a?aeiia?aeii. Iaea?aeai? aeai? ia?aeiieeai na?ae/aoue i?i oa, ui aa??aio Aaaio+ a?ae??ciy?oueny a?ae aa??aioo Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - ae?aaeaiith i?ioeiooeeiiith ae??th oa ia? a?eueo cia/iee aioeaeanoiiiee aoaeo, i?ae iie?ia??one aeo?aeii? iiioeyoe??. Aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - , ni?e/eiy? i?ioeeaaeiee aoaeo, a?i iaoyaeo? ia?aa?a iooeeiieo i?ioean?a, iacaeaaeii a?ae ?o aeaeo. Ioaea, ca?eueiaiiy iiioeyoe?? a?ae aa??aioo Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - aeaaioai?ii aieeaa? ia ?aae?caoe?th aioeaeanoiiieo iioaioe?e iie?ia??on?a. Ie oyaeyee nia? iiaeeea? iaoai?cie i?ioeiooeeiii? ae?? iie?ia??on?a ye aca?iiae?th aeayeeo oaeoi??a. Ii-ia?oa, caeaoi?noue iie?ia??on?a aei i?iieeiaiiy oa ?iciiiaeaiiy a oeaieiao iooeei, oiaoi iieie?oe/ia ae?y. Ii-ae?oaa, aeoeaaoe?y ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio oa oaeoi??a i?ioeiooeeiiiai ?ioi?oaoo. Aeey aecia/aiiy iieio?iiieo aeanoeainoae iie?ia??on?a canoiniaoaaee iaoiae oioinainea?e?caoe?? a??on?a i?ioeaa?iii. Ia i?eeeaae? ? oa ?? oei?a aeiaaaeaii, ui aaeoeeii? a??one iie?ii??e?oo caeaoi? ia eeoa aei i?iieeiaiiy, aea e aei ?iciiiaeaiiy a iooeeiieo ee?oeiao. A oeaieiao ye na?eiie, oae ? ea?oeeiiie ?ai?iaeoeoe?y aaeoeeiieo iie?ia??on?a a?aeaoaa?oueny a?eueo ?ioaineaii i?ae a eiio?ieueieo oeaieiao. Aea?aia iiaeaeue ea?oeeiiie Eueth?na ia?aaeaa/a? aaaaeaiiy iooeeiieo ee?oei a i`yciao oeaieio caaeiuei? eaie ieo?, aea ? a?aeaoaa?oueny ?icaeoie ia?aeiii? iooeeie. Oiio, i?e aeae?eaii? a??on?a ?c aeanoiie ca eiio?ieue i?aaeea ae?oaa ?ioaeoia eaia oaa?eie. ?acoeueoaoe aea/aiiy iieio?ii?cio iie?ia??on?a i?aaenoaaeai? ia ?en.1. ?en.1. ?ai?iaeoeoe?y aaeoeeiieo iie?ia??on?a a iooeeiieo oeaieiao oa i?aaiao ieoae. Oeeo?aie iicia/aia e?euee?noue a??on?a ia 1 a?ai oeaieie. Ca?aeii ?acoeueoaoai, iaea?aeaiei ia iiaeae? na?eiie ? ea?oeeiiie, ae?aciee iieio?ii?ci i?eoaiaiiee iie?ia??onai ye ?, oae ? ?? oeio. Aea i?ioaeoeaia i?ioeioo-eeiia ae?y aeiaaaeaia eeoa aeey AAII ?? oeio. E?euee?noue aeae?eaiiai ?c iooeeie iie?ia?-?ono II oeio iacia/iith i??ith ia?aaeuo? e?euee?noue a??ono I oeio. Oiio, aeoiaey/e eeoa c iieio?iiieo aeanoeainoae, ia iiaeia iiynieoe ??cieoeth i?ae aieeaii ia ?icaeoie io-oeeie AAII I oa II oei?a. Iieio?ii?ci oa ?iciiiaeaiiy iie?ia??on?a a ee?oeiao iooee-ie iiaeeeai ia yaey?oueny ?aeeiith i?e/eiith ?o aioeaeanoiiii? aeoeaiino?. ??cieoey i?ae ??aiai ?ai?iaeoeoe?? a??on?a I oa II oei?a iacia/ia, aea e?euee?noue a??onieo iauaaee?a, aeae?-eaieo ?c ee?oei na?eiie ((1,8 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,0025)o104 oa (2,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,077)o104 – aeey ? oa ?? oei?a a?aeiia?aeii) ia ii?yaeie ia?aaeuo? e?euee?noue iauaaee?a, ui aeae?eai? ?c ea?oeeiiie ((3,8 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,048)o103 oa (4,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,074)o103 aeey ? oa ?? oei?a a?aeiia?aeii). Oiaoi, ii a?aeiioaiith aei na?eiie 180 AAII aeoeai?oa i?iyaeythoue nai? iieio?iii? aeanoeaino?, i?ae aei ea?oeeiiie. Oea i?aeoaa?aeaeo? oie oaeo, ui, caaaeii, na?eiie a?eueo /ooeea? aei aioa?ia??on?a, i?ae iooeeie ai?aea?iaeueiiai iioiaeaeaiiy (Aa?eeaaa ?.?., 1977). Ia iiaeia aeeeth/aoe iiaeeeaino? oiai, ui iayai?noue ?ioaeoe?eiiai a??ono a iooeeiieo ee?oeiao i?ecaiaeeoue aei iaaii? ci?ie ?o aioeaaiieo oa?aeoa?enoee, oiaoi iaoiiaeth? aaoa?iaai?caoe?th iooeeiii? oeaieie, ?iaey/e ?? a?eueo ?ioiiaaiiith ? /ooeeaith aei niaoeeo?/ieo ?ioiieo oaeoi??a ?aaeoeaiino? i?aai?cio. sse a?aeiii iooeeii? ee?oeie ? neaaeeie aioeaaiaie (Einyeia I.I. e ae?., 1985), oiio i?aeneeaiiy ?o ?ioiiaaiiino? iiaea aooe cia/ouei oaeoi?ii, ui iioaioe?th? aeani? neee i?aai?cio aei i?ioeiooeei-iiai caoenoo. A i?aaenoaaeai?e ?iaio? iaaiaeyoueny aeai?, ui i?aeoaa?aeaeothoue ?ioiii?aaiio?ii?ci iie?ia??on?a ? aeiaiaeyoue caeaoi?noue iie?ia??on?a aei ?ai?iaeoeoe?? a i?aaiao ?ioiii? nenoaie, oaeeo ye oeion ? naeac?iea (?en.1). Ioaea, AAII iiaeooue ?aae?coaaoe nai? ?ioiiiiaeoethth/? aeanoeaino? i?e aaciina?aaeiueiio ?iciiiaeaii? a ee?oeiao ?ioiieo i?aai?a, cie?aia aeeeeeath/e i?aeneeaiiy i?iaeoeoe?? ?OI. Iniiaio ?ieue a i?ioeiooeeiiiio caoeno? i?aai?cio a?ae?a?athoue ianiaoeeo?/i? oaeoi?e (Aeae/iai A.E., 1984). Aaeeea cia/aiiy ia? ?ioa?oa?ii, aeoeai?noue IE ? IO, i?iaeoeoe?y OII. ?OI oa OII iathoue ia eeoa i?yio iooeeiioeeaeio aeoeai?noue, aea e ?aaoeththoue aca?iiae?th ?ioiieiiiaoaioieo ee?oei, yea aecia/a? oi?io-aaiiy ?ioiii? a?aeiia?ae?. Iaaaaeai? a ?iaio? aenia?eiaioe ua ?ac i?aeoaa?aeaeothoue, ui a?-?one a naith /a?ao aieeaathoue ia neioac oeeo oeeoie?i?a ?, a?aeiia?aeii, iiaeoeththoue ?ioiio ?aaeoeai?noue i?aai?cio. Aoei i?iaaaeaii aea/aiiy ?ioa?oa?iiiaiai noaoono, aeoeaiino? ii?iaeueieo e?ea??a oa i?iaeoeoe?? ne?iaaoeiaiai oaeoi?o iae?ico iooeei o ?ioaeoieo ieoae ia oii? ?ioi?caoe?? AAII, a oaeiae ii??aiyiiy ??aiy ianiaoeeo?/iiai caoenoo ieoae-iooeeiiiin??a, ?ioi?ciaaieo aaeoeeiieie iie?ia??onaie oa ia?ioi?ciaaieo. Aaeoeeii? iie?ia??one caeaoi? aieeaaoe ia ?ioa?oa?iiiaee noaoon i?aai?cio, yeee oa?aeoa?eco? ooieoe?iiaeueiee noai e?ioi?aeieo ee?oei e?ia? (oaae.4). Oaaeeoey 4. Aieea aaeoeeiieo iie?ia??on?a ia iieacieee ianiaoeeo?/ii? ?aaeoeaiino?. A??one Oa?i?ie aeine?aeaeaiiy 1 aeiaa 4 aeiaa 7 aeiaa 14 aeiaa iieacieee ne?iaaoeiaiai ?ioa?oa?iio (i?aeia?iaei? iaeeieoe?) I oei (n=21) 146,5 SYMBOL 177 \f "Symbol" \s 13.5 ± 12,88 ?<0,001 133,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 213,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 33,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 P>0,1

II oei

(n=21) 240,0 SYMBOL 177 \f «Symbol» \s 13.5 ± 25,76

?<0,001 266,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 586,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 51,53 ?<0,001 93,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 12,88 ?<0,01 III oei (n=21) 133,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 12,88 ?<0,001 146,5 SYMBOL 177 \f "Symbol" \s 13.5 ± 12,88 ?<0,001 240,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 86,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 19,32 ?<0,02 aac ?ioi?c. (n=21) 33,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 iieacieee ne?iaaoeiaiai oaeoi?a iae?ico iooeei (oeeoioiene/iee ?iaeaen a %) ? oei (n=21) 15,2 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,16 ?<0,01 18,5 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,32 ?<0,001 13,2 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,17 ?>0,1 12,1 SYMBOL 177 \f «Symbol» \s 13.5 ± 1,13

?<0,1 ?? oei (n=21) 18,8 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,81 ?<0,01 23,1 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,65 ?<0,001 14,8 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,16 ?<0,01 12,5 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,15 ?<0,1 ??? oei (n=21) 14,1 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,80 ?<0,1 20,9 SYMBOL 177 \f "Symbol" \s 13.5 ± 1,29 ?<0,001 14,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,81 ?<0,1 13,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,80 ?<0,1 aac ?ioi?c. (n=21) 11,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,97 iieacieee aeoeaiino? ii?iaeueieo e?ea??a (oeeoioiene/iee ?iaeaen a %) ? oei (n=21) 50,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,58 ?<0,001 39,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,39 ?<0,01 66,2 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,56 ?<0,001 17,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,50 ?<0,001 ?? oei (n=21) 62,1 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,48 ?<0,001 58,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,57 ?<0,01 73,2 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,75 ?<0,001 27,2 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,49 ?<0,001 ??? oei (n=21) 47,4 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,58 ?<0,001 40,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,38 ?<0,001 59,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,96 ?<0,001 33,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,42 ?<0,001 aac ?ioi?c. (n=21) 36,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,69 I?ei?oea: P- ??aaiue cia/ouino? ii a?aeiioaiith aei a?oie ia?ioi?ciaaieo oaa?ei. Iaeaeoeai?oei ?iaeoeoi?ii aiaeiaaiiiai ?OI yaey?oueny AAII II oeio. Iaeneiaeueiee oeo? ne?iaaoeiaiai ?OI i?e iie?ia??oni?e ?iaeoeoe?? niinoa??aa?oueny ia 7 aeiao ? ia?aaeuo? ??aaiue ?OI ?ioaeoiiai i?aai?cio a 17,62 ?ac?a. ?iaeoeoe?y a?aecia/a?oueny c 1 aeiae niinoa?aaeaiiy ? aeey AAII II noaiiaeoue 240,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 II, ui ia?aaeuo? aiaeia?/i? iieacieee aeey ?ioeo AAII. Acaaae?, e?euee?noue ?OI a e?ia? ieoae, ?ioi?ciaaieo oeei a??onii, ia?aaeuo? eiai e?euee?noue o oaa?ei, yeei aaiaeeee ?io? AAII. I?iaeoeoe?y oeueiai oeeoie?io nieaiioeeoaie i?ae ae??th ?iaeoeoi??a in vitro na?ae/eoue i?i caeaoi?noue eaeeioeeo?a neioacoaaoe ?OI. C iaeyaeo ia oa, ui AOI yaey?oueny ?iaeoeoi?ii A-e?ioioeeo?a, a i?oiaai Eii A - ?iaeoeoi?ii ee?oei O-nenoaie, iiaeia ca ia?aaaaeiith i?iaeoeoe??th SYMBOL 97 \f "Symbol" \s 14 a -oa SYMBOL 103 \f "Symbol" \s 14 g -?ioa?oa?iio iiina?aaeeiaaii noaeeoe i?i aeoeai?noue A- ? O-eaiie ?ioi?oaoo acaaae?. Nieaiioeeoe ieoae, ?ioi?ciaaieo iie?ia??onii ??? oeio, i?iaeoeothoue SYMBOL 97 \f "Symbol" \s 14 a -?OI a oeo?ao, ye? ia?aaeuothoue aiaeia?/io aeoeai?noue nieaiioeeo?a ?ioaeoieo ieoae a 1,82-8,01 ?ac?a. Iaeaeu? oeo?e SYMBOL 103 \f "Symbol" \s 14 g -?ioa?oa?iio ?iaeoeo? AAII II oeio. Iiia?aaeiy ?ioi?caoe?y oaa?ei aaeoeeiiei iie?ia??onii I oeio iacia/iith i??ith ni?ey? i?aeaeuaiith neioaco SYMBOL 103 \f "Symbol" \s 14 g -?ioa?oa?iio ? i?ney iacia/ii? noeioeyoe?? i?eai?/o? neioac SYMBOL 97 \f "Symbol" \s 14 a -?OI. Ia iniia? iaaaaeaieo aeaieo iiaeia c?iaeoe aeniiaie, ui AAII II oeio coiiaeth? ye aeae?eaiiy ?OI a e?ia, oae ? noeioeth? O-eaieo ?ioi?oaoo. A??on ??? oeio, e??i i?aeaeuaiiy ??aiy ?OI a ne?iaaooe? e?ia?, aeeeeea? aeoeaaoe?th A-e?ioioeeo?a. AAII, ye? yaeythoueny aeoeaieie ?iaeoeoi?aie ?OI, i?iyaeythoue ae?acio aioeaeanoiiio aeoeai?noue. Oea iiaea aooe iaoiiaeaii ye aaciina?aaeiueith aioei?ie?oa?aoeaiith ae??th ?ioa?oa?iio ia iooeeii? ee?oeie, oae ? caeaoi?noth eiai aeoeaoaaoe ?ioiioeeoe. Ca aeaieie e?oa?aoo?e, ia?iaea iae?ioaa?a ?ioa?oa?iiii i?aeneeth? i?iaeoeoe?th ?ioa?eaee?io-1, yeee ae?? ia ii?iaeuei? e?ea?e, noeioethth/e ?o iieie?oe/i? iioaioe?? (Oiaineee A.N., 1986). E??i oiai, ?OI caeaoiee aaciina?aaeiuei aeoeaoaaoe IE (Iao?ia ?.A., 1994). Oea ocaiaeaeo?oueny c ?acoeueoaoaie iaoeo aeine?aeaeaiue, i?i oa, ui ?ioi?caoe?y eiaeiei ?c o?ueio oei?a iie?ia??on?a aeoeao? oeeoioiene/i?noue ii?iaeueieo e?ea?ieo ee?oei ieoae (oaae.4). AAII II oeio, yeee aeyaeany iaeae?aci?oei ?iaeoeoi?ii ?ioa?oa?iio, neeuei?oa ca an?o aeoeaoaaa IE. C e?oa?aoo?e a?aeiii, ui oaeoi? iae?ico iooeei o iaaaeeeeo e?eueeinoyo iaiao?aeiee aeey aaeaeaaoii? ?ioiii? a?aeiia?ae? acaaae? ? i?ioeiooeeiii? cie?aia. Iacia/ia i?aeaeuaiiy e?eueeino? OII, yeee ?iaeoeothoue an? o?e oeie aaeoeeiieo iie?ia??on?a (oaae.4), ni?ey? aeoeaaoe?? i?ioeiooeeiiiai ?ioi?oaoo. C iaeyaeo ia oa, ui iaeiei ?c iniiaieo i?iaeooeaio?a ? iaeii/anii ?aoeei??io?a OII ? iae?ioaae, iiaeia noaeeoe ? i?i aeoeai?noue oeeo ee?oei, ye? a?ae?a?athoue aaeeeo ?ieue a i?ioeiooeeiiiio caoeno? i?aai?cio. E??i oiai, OII i?aeneeth? i?iieeeea?noue aiaeioae?th ? ?iaeoeo? oaiioaenen iiiioeeo?a, iaeo?io?e?a oa ?ioeo ?ioiioeeo?a a oeaieie, ui ni?ey? ianiaoeeo?/iiio oeeoie?co iooeeiieo ee?oei (Noneia A.I., 1990). Aecia/aiiy iieaciee?a ianiaoeeo?/ii? ?acenoaioiino? o ieoae c iooeeiaie iieacaei, ui iaiieanoe/iee i?ioean aeeeeea? noi?an?th ?ioii?aaeoeaiino? i?aai?cio (oaae.5). Oaaeeoey 5. Aieea iie?ia??on?a ia oaeoi?e ianiaoeeo?/iiai caoenoo o ieoae c aenia?eiaioaeueieie iooeeiaie A??on Aeoea-i?noue IE ??aaiue ?OI ??aaiue OII S SYMBOL 97 \f "Symbol" \s 14 a SYMBOL 103 \f "Symbol" \s 14 g Na?eiia 180 aac ?ioi?caoe?? (n=21) 26,2 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,42 1173,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 103,3 36,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 23,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 39,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 1,78 AAII ?? oeio (n=21) 37,4 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,61 ?<0,001 266,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 93,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 12,88 ?<0,001 73,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 6,44 ?<0,001 27,4 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,86 ?<0,001 Ai?aea?ii?aeia ea?oeeiiia eaaaiue Eueth?na aac ?ioi?caoe?? (n=21) 17,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,57 2346,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 103,1 33,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 6,67 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 49,9 SYMBOL 177 \f "Symbol" \s 13.5 ± 1,29 AAII ??? oeio (n=21) 30,34 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,49 ?<0,001 533,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 51,53 ?<0,001 133,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 30,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 ?<0,001 31,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,97 ?<0,001 Eaeeic ?aooa?a aac ?ioi?caoe?? (n=21) 20,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,37 1066,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 103,1 36,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 16,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 29,1 SYMBOL 177 \f "Symbol" \s 13.5 ± 1,45 AAII ??? oeio (n=21) 32,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,50 ?<0,001 373,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 51,53 ?<0,001 266,7 SYMBOL 177 \f "Symbol" \s 13.5 ± 25,76 ?<0,001 33,3 SYMBOL 177 \f "Symbol" \s 13.5 ± 3,22 ?<0,02 19,0 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,81 ?<0,001 I?ei?oee: 1 S - ??aaiue ne?iaaoeiaiai ?ioa?oa?iio SYMBOL 97 \f "Symbol" \s 14 a , SYMBOL 103 \f "Symbol" \s 14 g - oeo? SYMBOL 97 \f "Symbol" \s 14 a - oa SYMBOL 103 \f "Symbol" \s 14 g -?ioa?oa?ii?a, ui i?iaeoeothoueny in vitro nieaiioeeoaie, ia?iaeaieie a?aeiia?aeieie ?iaeoeoi?aie 2. Oeeo?aie a oaaeeoe? i?aaenoaaeaii: ??aaiue ?ioa?oa?iio (i?aeia?iaei? iaeeieoe?) iieacieee oaeoi?o iae?ico iooeei oa aeoeai?noue ii?iaeueieo e?ea??a (cia/aiiy oeeoioiene/iiai ?iaeaeno a %) 3. P- ??aaiue cia/ouino? ii a?aeiioaiith aei a?oie ia?ioi?ciaaieo oaa?ei. Aiia ae?aaeaeany a i?eai?/aii? oeeoioiene/ii? aeoeaiino? ii?iaeueieo e?ea??a. O ieoae-iooeeiiiin??a a?aeaoaaany i?aeneeaiee neioac aiaeiaaiiiai ?ioa?oa?iio (oaae.5), yeee neoaeeoue iiaaiith i?iaiinoe/iith iciaeith noiniaii ?icaeoeo iaoieia?/-iiai i?ioeano ? i?ecaiaeeoue aei i?eai?/aiiy ee?oeiiiai ?ioi?oaoo, ui ae?aaea?oueny a cie-aeaii? caeaoiino? nieaiioeeo?a aei i?iaeoeoe?? SYMBOL 97 \f "Symbol" \s 14 a - oa SYMBOL 103 \f "Symbol" \s 14 g -?OI (Caineia A.I., 1983). ?ioi?ciaa-i? AAII oaa?eie-iooeeiiiin?? iaee a?eueo aenie? iieacieee oeeoioiene/ii? aeoeaiin-o? IE-ee?oei. O ieo ciaiooaaany ??aaiue ne?iaaoeiaiai ?ioa?oa?iio, ui oaeiae ? iice-oeaiei iiiaioii (A?oia O.E., 1996), a?aeiiaethaaeanue caeaoi?noue ?iaeoeiaaieo nieaii-oeeo?a neioacoaaoe in vitro SYMBOL 97 \f "Symbol" \s 14 a - oa SYMBOL 103 \f "Symbol" \s 14 g -?OI. ?ioi?caoe?y ieoae c aeanoiiaie iaoiiaethaaea cieaeaiiy e?eueeino? oee?eoethth/iai OII, oiae? ye ia?ioi?ciaai? oaa?eie iaee iaoieia?/ii aenie? ??ai? oeueiai oeeoie?io. Oeae oaeo ia? aaaeeeaa cia/aiiy, ine?eueee a?aeiii, ui naia iaaenie? eiioeaio?aoe?? OII noeioeththoue i?ioean aeoeaaoe?? ?ioiioeeo?a ? iaiao?aei? aeey ?aaoeyoe?? ??cieo noaiiioeyoe?e ?ioiieiiiaoaioieo ee?oei, oiae? ye aeniea e?euee?noue iiaea aeeeeeaoe ooeiaeaeaiiy oeaiei, oie ? iaa?oue eaoaeueiee e?iaoeue (Aggarwall B., 1995). Aeoiaey/e c ?acoeueoao?a i?iaaaeaieo aenia?eiaio?a, ie i?eeoee aei caeeth/aiiy, ui i?ia?aeieie iaoai?ciaie, ui eaaeaoue a iniia? iiaeoeyoe?? iie?ia??onaie ia?aa?ao aeanoiiieo i?ioean?a, yaey?oueny aeoeaaoe?y i?ioeiooeeiieo ianiaoeeo?/ieo oaeoi??a caoenoo i?aai?cio. Aeaeo?iiii-i?e?ineii?/i? aeine?aeaeaiiy i?aeoaa?aeaeothoue caeaoi?noue iie?ia??on?a ?iciiiaeoaaoeny a ee?oeiao iooeei. Ca?aeii iaea?aeaiei ?acoeueoaoai, ?ioi?caoe?y ieoae-iooeeiiiin??a aeoeao? i?ioean i?a?aoe?? iae?ioaa?a a iooeeiio oeaieio, ui ni?ey? ?aa?an?? iooeeiii? oeaieie. I?iaaaeai? aeine?aeaeaiiy iieacaee, ui o ieoae c eaeeicii ?aooa?a, ?ioi?ciaaieo aaeoeeiiei iie?ia??onii ??? oeio, ooeiaeaeaiiy ee?oei e?noeiaiai iiceo aoee ia oaeeie cia/ieie, ye o ia?ioi?ciaaieo oaa?ei. Aeniiaee. 1. Aeiaaaeaii, ui ?ioi?caoe?y ieoae aaeoeeiieie ooaiaie a??on?a iie?ii??e?oo aieeaa? ia ia?aa?a aenia?eiaioaeueieo iooeei. A caeaaeiino? a?ae oeio a??on?a ? aeaeo iooeei oeae aieea iiaea i?iyaeyoeny ye a aaeueioaaiiy, oae ? a noeioeyoe?? aeanoiiiiai i?ioeano. 2. Aaeoeeiiee iie?ia??on ?? oeio - P-712,ch 2ab, i?iyaey? ae?acio i?ioeiooeeiio aeoeai?noue ii a?aeiioaiith aei an?o o?ueio aeei?enoaieo a ?iaio? iiaeaeae iooeei ieoae: i?ecaiaeeoue aei ciaioaiiy na?aaeiuei? iane na?eiie 180 ia 50% oa aei ca?eueoaiiy na?aaeiuei? o?eaaeino? aeeooy ia 44%. ni?e/eiy? cieaeaiiy na?aaeiuei? iane ai?aea?ii?aeii? ea?oeeiiie eaaaiue Eueth?na ia 37%, i?aeaeuaiiy na?aaeiuei? o?eaaeino? aeeooy ia 15,8% oa ciaioaiiy e?eueeino? iaoanoac?a a 1,3 ?ace. iaoiiaeth? ca?eueoaiiy na?aaeiuei? o?eaaeino? aeeooy i?e eaeeic? ?aooa?a ia 53,7%. 3. ?ioi?caoe?y aaeoeeiiei iie?ia??onii ??? oeio – Leon12 ab, ia? i?ioaeoeaio ae?th a?aeiinii ia?aa?ao aeaio aea/aieo aeanoiiieo i?ioean?a o ieoae: i?e ea?oeeiii? Eueth?na aeeeeea? cieaeaiiy na?aaeiuei? iane iooeei ia 42,9%, iiaeiaaeaiiy na?aaeiuei? o?eaaeino? aeeooy ia 26,5% oa ciaioaiiy e?eueeino? iaoanoac?a a 1,57 ?ac?a i?e eaeeic? ?aooa?a i?ecaiaeeoue aei ca?eueoaiiy na?aaeiuei? o?eaaeino? aeeooy a 8,5 ?ace 4. Ia i?eeeaae? aaeoeeiiiai iie?ia??ono ? oeio - LSn2ab, aeiaaaeaii, ui a??onia ?ioi?caoe?y iiaea iaoiiaethaaoe noeioeyoe?th iooeeiiiai ?inoo: na?aaeiy iana iooeei ieoae ?c na?eiiith 180, ?ioi?ciaaieo oeei ooaiii i?aeaeuoaaeany ia 26%, ii??aiyii c eiio?ieai e?euee?noue iaoanoac?a o ieoae c ea?oeeiiiith Eueth?na, yeei aaiaeeee a??on ? oeio, ca?eueooaaeinue a 1,53 ?ace. Iiae?aiee aoaeo aeyaeaii i?e aaaaeaii? ieoai i?aia?aoo, ui neeaaeaany c on?o o?ueio ooai?a aaeoeeiieo iie?ia??on?a. 5. Iiioeyoe?y iie?ia??on?a iaiaeii??aeia ca aieeaii ia iooeeiiee i?ioean: aaioii?oiaee aa??aio Aaaio+ a?ae??ciy?oueny a?ae aeo?aeii? iiioeyoe?? ae?aci?oei i?ioeiooeeiiei aoaeoii, aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - , iaaiaee, iaoyaeo? ia?aa?a aeanoiiiiai i?ioeano. Oea aeiaaaeaii ia i?eeeaae? iie?ia??ono ?? oeio - aa??aio Aaaio+ iaoiiaeth? cieaeaiiy na?aaeiuei? iane na?eiie 180 a 3,6 ?ace, ea?oeeiiie a 1,85 ?ace oa ciaioaiiy e?eueeino? iaoanoac?a a 3,43 ?ace aa??aio Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - noeioeth? iooeeiiee i?ioean - na?aaeiy iana na?eiie ca?eueoo?oueny ia 115,6 %, ea?oeeiiie ia 47,9% oa e?euee?noue iaoanoac?a i?aeaeuo?oueny a 2 ?ace. 6. AAII i?iyaeythoue ae?aci? iieio?iii? aeanoeaino?, aiie caeaoi? aei ?ai?iaeoeoe?? a iooeeiao, ui aeiaaaeaii c aeei?enoaiiyi iaoiaeo oioinainea?e?caoe?? a??on?a i?ioeaa?iii. Na?aaeiy eiioeaio?aoe?y a??on?a a iooeeiao noaiiaeoue a?ae (3,8 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,048)o103 aei (2,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,077)o104 OOeAe50/a oeaieie. 7. Aaeoeeii? iie?ia??one ? neeueieie ?ioiiiiaeoeyoi?aie. I?ioaeoeaia aioeaeanoiiia aeoeai?noue AAII ii a?aeiioaiith aei na?eiie 180, ea?oeeiiie Eueth?na oa eaeeico ?aooa?a o ieoae iaoiiaeaia iiaeoeyoe??th oaeoi??a ianiaoeeo?/ii? i?ioeiooeeiii? ?acenoaioiino?. aaeoeeii? iie?ia??one noeioeththoue neioac ne?iaaoeiaiai ?ioa?oa?iio, i?aeneeththoue i?iaeoeoe?th ?iaeoeiaaiiai SYMBOL 97 \f "Symbol" \s 13.5 a - oa SYMBOL 103 \f "Symbol" \s 13.5 g -?ioa?oa?iio, ni?eythoue aeoeai?e i?iaeoeoe?? oaeoi?o iae?ico iooeei oa i?aeaeuothoue ooieoe?iiaeueio aeoeai?noue i?e?iaeieo e?ea??a. ?ioi?caoe?y aaeoeeiieie iie?ia??onaie ni?ey? a?aeiiaeaiith oaeoi??a ianiaoeeo?/ii? ?acenoaioiino? ieoae-iooeeiiiin??a. Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe??. 1. Ei?ithoaiei I.I., Oe?iaieia A.I., Ao?ai??aa I.A. ?ioiii?aaiio?i?ci a??on?a iie?ii??e?oo // AEo?iae AII Oe?a?ie.- 1997.- o.3, ?2.- N.291-299. 2. Ei?ithoaiei I.I., Oe?iaieia A.I., Ao?ai??aa I.A., Ne/iaa A.A., Oeeia I.A. Aca?iiae?y aioa?ia??on?a c ?ioiiith nenoaiith // Aeiiia?ae? IAI Oe?a?ie.- 1997.- ?6.- N.181-183. 3. Ao?ai??aa I.A. Aea/aiiy ?ioiieia?/ieo iaoai?ci?a iieii?ioaeoeaii? ae?? aaeoeeiieo iie?ia??on?a // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.- ?23.- N.53-55. 4. Ao?ai??aa I.A., Oe?iaieia A.I. Aieea iie?ia??on?a ia ?icaeoie aenia?eiaioaeueieo iooeei // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.- ?24.- N.19-22. 5. Oe?iaieia A.I., Aiiniaa E.I., Ei?ithoaiei I.I., Ao?ai??aa I.A. oa ?i. ?ieue aioa?ia??on?a a ia?ioaeoe?ei?e iaoieia?? // I?iaeaie iaaeeoeeie.- 1998, ?3.- N.20-25. 6. Ao?aiaaaa I.A., Oe?iaieia A.I. Ei?ithoaiei I.I. Aeeyiea iieeiae?onia ia iiooieaaue i?ioeann // International Journal on Immunoreabilitation.- 1997.- ?4.- N.148. 7. Ao?ai??aa I.A., Ei?ithoaiei I.I., E?eaioaonueea E.Ae. Aieea aaeoeeiieo iie?ia??on?a ia iieacieee ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio ieoae // Aeooaeuei? ieoaiiy iaaee/ii? i?e?ia?ieia?? oa a??onieia??. Ca??iee i?aoeue aei 100-??//y aeiy ia?iaeaeaiiy N.Aey/aiea.- Ee?a:- 1998.- N. 91-95. 8. Ao?ai??aa I.A., Oe?iaieia A.I., Noa/aiei E.A. Oeueo?ano?oeoo?ia ia?aaoaeiaa iooeeiii? oeaieie i?ae ae??th iieio?iiieo iie?ia??on?a // A?niee A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo.- 1998.- aei.6., /ano.2- N.3-5. 9. Ei?ithoaiei I.I., Oe?iaieia A.I., Ao?ai??aa I.A., Aiae???iei O.A., Eicae ?.A. Oeueo?ano?oeoo?i? ci?ie i?aai?a ?ioiii? nenoaie i?ae aieeaii a??on?a iie?ii??e?oo // A?niee A?eioea?e?anueeiai aea?aeaaiiai aa?a?iiai oi?aa?neoaoo.- 1998.- aei.6., /ano.1- N.30-33. 10. Ne/iaa A.A., Oe?iaieia A.I., Ei?ithoaiei I.I., Ao?ai??aa I.A. Iniaeeaino? ?ioiiiaoiaaiaco aenia?eiaioaeueii? noao?eieieiai? ?ioaeoe?? ia oii? ?ioi?caoe?? a??onaie iie?ii??e?oo// Oe?. iaoe.-iaae. iieiae. aeo?i.- 1997.-?1-2.-N.22-25. 11. Achramejeva N., Kornjushenko O., Shirobokov V. The inhibition of growth of the experimental tumours by Entheroviruses and its possible mechanism // Abstract 10th International congress of virology.- Jerusalem, Israel.- 1996.- P.239. 12. Shirobokov V., Sitchova V., Kornjushenko O., Shilov M., Achramejeva N. Polioviruses as immunomodulators // Abstract 10th International congress of virology.- Jerusalem, Israel.- 1996.- P. 238. 13. Oe?iaieia A. I., Ei?ithoaiei I.I., Ao?aia?aa I. A., Ne/iaa A. A., Einothe I. A. ?ioiio?ii?ci a??on?a iie?ii??e?oo // Oace aeii. I?aeia?. iaoe. eiio., i?ena. 150-??//th c aeiy ia?iaeaeaii Ia/ieeiaa.- Oa?e?a.- 1995.- N. 159. Aiioaoe?y Ao?ai??aa I.A. Aieea a??on?a iie?ii??e?oo oa ?o aaioii?oiaeo aa??aio?a ia iooeeii? i?ioeane a aenia?eiaio?. – ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa a?ieia?/ieo iaoe ca niaoe?aeuei?noth 03.00.06 – a??onieia?y.- Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I.I.Aiaiiieueoey, Ee?a, 1999. ?iaioa i?enay/aia aea/aiith aieeao aaeoeeiieo a??on?a iie?ii??e?oo oa ?o aaioii?oiaeo aa??aio?a ia aenia?eiaioaeuei? iooeeii? i?ioeane. Anoaiiaeaii, ui an? o?e oeie aaeoeeiieo iie?ia??on?a iathoue iieiiiaeoethth/? aeanoeaino?, oa?aeoa? oa ?ioaineai?noue ?o aieeao caeaaeaoue ye a?ae oeio a??ono, oae ? a?ae aeaeo iooeeie. I?e aeine?aeaeaii? i?ioeiooeeiieo aeanoeainoae iie?ia??on?a ia ??ai? aaoa?iaaiii? iiioeyoe??, aeiaaaeaii, ui aaioii?oiaee aa??aio Aaaio+ ia? iaea?eueoee i?ioeiooeeiiee aoaeo, aa??aio iiioeyoe?? Aaaio SYMBOL 45 \f "Symbol" \s 13.5 - , iaaiaee, iaoiiaeth? i?ia?an?th iooeeiiiai i?ioeano. Iaeiei c iiaeeeaeo iaoai?ci?a ci?ie iie?ia??onaie ?ioaineaiino? aeanoiiiiai ?inoo iiaea aooe aieea, yeee aiie ni?e/eiythoue ia oaeoi?e ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio ieoae. Anoaiiaeaii, ui iie?ia??one caeaoi? ci?ithaaoe a e?ia? ??aaiue aaaeeeaeo iaae?aoi??a ?ioi?oaoo - ?ioa?oa?iio, oaeoi?o iae?ico iooeei. Aeoeai?noue ii?iaeueieo e?ea??a ieoae, ?ioi?ciaaieo aaeoeeiieie iie?ia??onaie, aoea aeuith, i?ae o ?ioaeoieo. Aeiaaaeaii, ui a??one iie?ii??e?oo iathoue iieio?iii? aeanoeaino?, aiie caeaoi? ?iciiiaeoaaoenue a iooeeiieo ee?oeiao. Aeena?oaoe?eia ?iaioa ? oai?aoe/iei iaa?oiooaaiiyi a??ioa?ai??, ye iao?aaeeoe?eiiai iai?yieo e?eoaaiiy iieieia?/ieo caoai?thaaiue. Eeth/ia? neiaa: aaeoeeii? a??one iie?ii??e?oo, aa??aioe iiioeyoe?? iie?ia??on?a, aenia?eiaioaeuei? iooeeie, ianiaoeeo?/i? oaeoi?e caoenoo, iieiiiaeoeyoe?y, ?ioiiiiaeoeyoe?y. Achramejeva N. Influence of poliomyelitis viruses and them bentonit variants to cancer processes in experiment. - The manuscript. The thesis for the scientific degree of candidate of biological sciences by speciality 03.00.06-virology. Bogomolets National medical university, Kiev, 1999. The dissertation is devoted to research of influence of vaccine poliomyelitis viruses and them bentonit variants to experimental cancer processes. Is established, that all three types of vaccine polioviruses have oncomodulation property. Character and intensity of their influence depend on a type of a virus and from a kind of a tumour. With research properties of polioviruses at a level of a heterogeneous population, is proved, that bentonit variant Abent+ renders greatest antitumour effect, variant Aaaio(, on the contrary, causes a progression of tumours process. To one of possible mechanisms of change polioviruses of intensity of blastoma growth, can be influence, which they render on the factors unspecific resistence of organizm of mice. Is established, that polioviruses are capable to change in blood a level important mediators of immunity - interferon, tumours necrotic factor. The activity normal killers of mice, who were immunized of vaccine polioviruses, was above, than at intact. Is proved, that the viruses of poliomyelitis have oncotropic property, they are capable to be made multiple copies in tumor cells. The dissertation work is a theoretical substantiation of virotherapy, as untraditional direction of treatment oncocogy diseases. Key words: vaccine viruses of poliomyelitis, variant of population of polioviruses, experimental tumours, factors unspecific resistence, oncomodulation, immunomodulation. Ao?aiaaaa I.A. Aeeyiea ae?onia iieeiieaeeoa e eo aaioiieoiauo aa?eaioia ia iiooieaaua i?ioeannu a yenia?eiaioa. – ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo iaoe ii niaoeeaeueiinoe 03.00.06 – ae?onieiaey, Iaoeeiiaeueiue iaaeeoeeineee oieaa?neoao ei. A.A.Aiaiiieueoea, Eeaa, 1999. ?aaioa iinayuaia yenia?eiaioaeueiiio eco/aieth iieiiiaeoee?othuaai aeaeno-aey aaeoeeiiuo ae?onia iieeiieaeeoa e eo aaioiieoiauo aa?eaioia. Onoaiiaeaii, /oi ana o?e oeia aaeoeeiiuo iieeiae?onia niiniaiu aeeyoue ia oa/aiea iiooieaaiai i?ioeana. Oa?aeoa? e eioaineaiinoue yooaeoa caaenyo eae io oeia ae?ona, oae e io aeaea iiooiee. Iaeaieaa au?aaeaiiia i?ioeaiiiooieaaia aeaenoaea ii ioiioa-ieth e yieaea?iieaeiie ea?oeeiiia eaaeeo Euethena e ae?oneiaeooee?iaaiiiio eaeeico ?aooa?a i?iyaeyao iieeiae?on ??? oeia - Leon12ab. O aeeaioiuo n ea?oeeiiiie, eiioiece?iaai-iuo aeaiiui ae?onii, ianna iiooieae oiaiueoaeanue ia 42,0 % , eiee/anoai iaoanoacia nieaeaeinue ia 36,2 %, a i?iaeieaeeoaeueiinoue aeecie oaaee/eaaeanue ia 26,5 % ii n?aa-iaieth n eiio?ieai. N?aaeiyy i?iaeieaeeoaeueiinoue aeecie iuoae n eaeeicii, eiioiece-?iaaiiuo yoei ae?onii, auea a 8,56 ?ac auoa, /ai o eioaeoiuo. Iaeaieaa aooaeoe-aiie ia iiaeaee na?eiiu 180 ieacaeanue eiioiecaoeey iieeiae?onii ?? oeia - P-712,ch 2ab. Iuoe, eioi?ui aaiaeeee iacaaiiue ae?on, eiaee n?aaeithth i?iaeieaee-oaeueiinoue aeecie ia 44% aieueoa e n?aaeithth ianno iiooiee a 1,65 ?ac iaiueoa, /ai iaeiioiece?iaaiiua aeeaioiua. Ia i?eia?a aaeoeeiiiai iieeiae?ona ? oeia - LSn2ab – iieacaii, /oi ae?oniay eiioiecaoeey iiaeao niinianoaiaaoue i?ia?annee iiooieaaiai ?inoa. Ianna iiooieae o iuoae n na?eiiie iiae aeeyieai yoiai ae?ona aic?anoaea ia 26%, a eiee/anoai iaoanoacia o iuoae n ea?oeeiiiie oaaee/eaaeinue a 1,52 ?aca. Iiioeyoeey iieeiae?onia iaiaeii?iaeia, a i?ioeanna ?ai?iaeoeoeee yioa?iae?onu aeennioeee?otho ia aaioiieoiaua aaiaoe/aneea aa?eaiou, eioi?ua ioee/athony ae?oa io ae?oaa ii iaeioi?ui aeieiae/aneei ia?aiao?ai, a oii /enea e ii aeeyieth ia iiooieaaue i?ioeann. Aa?eaio Aaaio+ ieacuaaao aieaa au?aaeaiiia i?ioeaiiiooieaaia aeaenoaea, /ai ae?onu enoiaeiie aaoa?iaaiiie iiioeyoeee. O iuoae, eiioiece?iaaiiuo aa?eaioii Aaaio+ , n?aaeiyy ianna na?eiiu auea a 3,6 ?aca ieaea, /ai o iuoae eiio?ieueiie a?oiiu e a 1,6 ?aca iaiueoa, /ai o aeeaioiuo, eioi?ui aaiaeeee ae?onu enoiaeiie iiioeyoeee. Aiaeiae/iua ?acoeueoaou auee iieo/aiu e ia iiaeaee ea?oeeiiiu Euethena. Aa?eaio Aaaio+ iaoneiaeeaaao nieaeaiea iannu iiooiee ii/oe a 2 ?aca e oiaiueoaiea eiee/anoaa iaoanoacia a 3,43 ?aca ii n?aaiaieth n eiio?ieai. Aa?eaio Aaaio( ieacuaaao i?ioeaiiieiaeiue yooaeo. Ianna iiooieae o aeeaioiuo n na?eiiie 180, eiioiece?iaaiiuo aa?eaioii Aaaio(, auea a 2,16 ?ac, /ai o eiio?ieueiuo iuoae. Eiee/anoai iaoanoacia o aeeaioiuo n ea?oeeiiiie, eioi?uo eiioiece?iaaee aa?eaioii Aaaio(, i?aauoaei aiaeiae/iue iieacaoaeue a eiio?ieueiie a?oiia a 2,04 ?aca. Iaoaieciaie iieiiiaeoee?othuaai yooaeoa ae?onia iiaoo neoaeeoue i?yiie iieieec, aaoa?iaaiecaoeey iiooieaauo eeaoie e eiioiiiiaeoee?othuaa aeaenoaea ae?onia. Auee iinoaaeaiu yenia?eiaiou, iai?aaeaiiua ia eco/aiea iieio?iiiuo naienoa iieeiae?onia. I?iaaaeaia ioeaiea eo aeeyiey ia oaeoi?u ianiaoeeoe/aneie caueou, eioi?ua ea?atho aaaeouoth ?ieue a i?ioeaiiiooieaaie ?acenoaioiinoe. Aeey auyaeaiey iieio?iiecia aaeoeeiiuo iieeiae?onia eniieueciaaee iaoiae oioinaineaeeecaoeee ae?onia i?ioeaaeiii. Ia i?eia?a ? e ?? oeiia aeieacaii, /oi ae?onu iieeiieaeeoa niiniaiu ia oieueei i?iieeaoue, ii e ?iciiiaeaoueny a iiooieaauo eeaoeao. A oeaie na?eiiu e ea?oeeiiiu ?ai?iaeoeoeey iieeiae?onia i?ienoiaeeo aieaa eioaineaii, /ai a eiio?ieueiuo oeaiyo. N?aaeiyy eiioeaio?aoeey ae?onia a iiooieyo ninoaaeyea io (8 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,048)o103 aei (2,6 SYMBOL 177 \f "Symbol" \s 13.5 ± 0,077)o104 OOeAe50 ia a?aii oeaie. E?iia oiai, ?ai?iaeoeoeey iieeiae?onia i?ienoiaeeo a eiioiiieiiiaoaioiuo eeaoeao, /oi iiaeao auoue cia/eiui oaeoi?ii, iioaioee?othuei neeu i?aaiecia, iai?aaeaiiua ia i?ioeaiiiooieaaoth caueoo. Ecaanoii, /oi a i?ioeanna ?acaeoey iiaiia?aciaaiee i?ienoiaeeo iauay eiio-iinoi?anney i?aaiecia, eioi?ay i?iyaeyaony eae a ineaaeaiee niaoeeoe/aneiai ei-ioiiiai ioaaoa, oae e a oaiaoaiee ianiaoeeoe/aneie ?acenoaioiinoe. Yoi auei iiaeo-aa?aeaeaii yenia?eiaioaie, i?aaenoaaeaiiuie a aeaiiie ?iaioa. O iuoae n ea?oeeiiiie Euethena iieacaoaee ooieoeeiiaeueiie aeoeaiinoe ii?iaeueiuo eeeea?ia ninoaaeyee 17,6(0,57 % (cia/aiea oeeoioiene/aneiai eiaeaena a %), /oi aieaa /ai a 2 ?aca ieaea iieacaoaey o eioaeoiuo iuoae. Iaaethaeaeinue oaeaea oiaiueoaiea eiaeooee?iaaiiiai neioaca (- e (-eioa?oa?iiia in vitro. Yoi naeaeaoaeuenoaoao i nieaeaiee iioaioeeaeueiie aeoeaiinoe eiioiioeeoia. Ia iiaeaee na?eiiu e eaeeica iaaethaeaeanue aiaeiae/iay oaiaeaioeey. O iiooieaauo iuoae ioia/aeinue /?acia?iia oaaee/aiea o?iaiy nuai?i-oi/iiai eioa?oa?iia e oaeoi?a iae?ica iiooieae, oa?aeoa?iia aeey aeanoiiiiai i?i-oeanna. A ?aaioa i?aaenoaaeaiu aeieacaoaeuenoaa niiniaiinoe aaeoeeiiuo iieeiae?onia aeoeae?iaaoue oaeoi?u ianiaoeeoe/aneie caueou. Ii?iaeueiay eeeea?iay aeoeaiinoue nieaiioeeoia iuoae, eiioiece?iaaiiuo iieeiae?onaie, /a?ac 1 nooee ninoaaeyea io 47,4(0,58 % aei 62,1(0,46 %, /oi aeinoiaa?iii i?aauoaao eiio?ieueiue iieacaoaeue (36,6(0,69 %). Aneaaenoaea eiioiecaoeee o aeeaioiuo iaaethaeaeanue eiaeoeoeey neioaca oaeeo iaaeeaoi?ia eiioieoaoa, eae eioa?oa?ii e oaeoi? iae?ica iiooieae. Iiauoae-ny neioac eiaeooee?iaaiiiai ( - e (-eioa?oa?iiia in vitro. O iuoae-iiooieaiineoaeae, eioi?ui aaiaeeee aaeoeeiiua iieeiae?onu, i?ienoiaeeea aeoeaaoeey oaeoi?ia ianiaoee-oe/aneie ?acenoaioiinoe, /oi a eiia/iii n/aoa, iaoneiaeeaaei i?ioeaiiiooieaaue yooaeo ae?onia iieeiieaeeoa. Oaeei ia?acii, i?aaenoaaeaiiay aeenna?oaoeeiiiay ?aaioa, yaeyaony oai?aoe/aneei iainiiaaieai ae?ioa?aiee, eae iao?aaeeoeeiiiiai iai?aaeaiey a ea/aiee iieieiae/aneeo caaieaaaiee. Eeth/aaua neiaa: aaeoeeiiua ae?onu iieeiieaeeoa, aa?eaiou iiioeyoeee iieeiae-?onia, yenia?eiaioaeueiua iiooiee, ianiaoeeoe/aneea oaeoi?u caueou, iieiiiaeoeyoeey, ei-ioiiiiaeoeyoeey. PAGE PAGE 21

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