Швидкість поширення ультразвуку в скловидному тілі ока як діагностичний показник ступеня внутрішньоочних посттравматичних змін: Автореф. дис… канд.

?INOEOOO I*IEO OAI?IA ? OEAIEIII? OA?AI??

?i. A.I. O?EAOIAA

EIAAEUe*OE IEAENAIAe? AAI?A?EIAE*

OAeE 617.7-001-06-079+534.292

OAEAeE?NOUe IIOE?AIIss OEUeO?ACAOEO

A NEEIAEAeIIIO O?E? IEA ssE Ae?AAIINOE*IEE IIEACIEE NOOIAIss
AIOO??OIUeII*IEO IINOO?AAIAOE*IEO CI?I

14.01.18 ( I/i? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

IAeANA ( 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a ?inoeooo? i/ieo oai?ia ? oeaieiii? oa?ai??

?i. A.I. O?eaoiaa AII Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

Eiaae ?aai Ieoaeeiae/,

?inoeooo i/ieo oai?ia ? oeaieiii? oa?ai??

?i. A.I. O?eaoiaa, aee?aeoi?

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee Aia?iaa Iaae?y Oaaei??aia,

?inoeooo i/ieo oai?ia ? oeaieiii? oa?ai??

?i. A. I. O?eaoiaa, ea??aiee a?aeae?eaiiy aeeoy/i? iooaeueiieia??;

aeieoi? iaaee/ieo iaoe, i?ioani? Noo?ia Ethaeieea Ieaen??aia,
Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I. Ai?ueeiai,
caa?aeoth/a eaoaae?ith i/ieo oai?ia

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?
ina?oe ?i. I.E. Ooieea, eaoaae?a i/ieo oai?ia, IIC Oe?a?ie, i.Ee?a

Caoeno a?aeaoaeaoueny “17” /a?aiy 1999 ?. i 14 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.556.01 a ?inoeooo? i/ieo oai?ia ?
oeaieiii? oa?ai?? ?i. A.I. O?eaoiaa AII Oe?a?ie ca aae?anith: 270061,
Oe?a?ia, i. Iaeana, O?aioeocueeee aoeueaa?, 49/51.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? ?inoeoooo i/ieo
oai?ia ? oeaieiii? oa?ai?? ?i. A.I. O?eaoiaa AII Oe?a?ie (270061,
Oe?a?ia, i. Iaeana, O?aioeocueeee aoeueaa?, 49/51).

Aaoi?aoa?ao ?ic?neaiee “_17__” o?aaiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe, i?ioani?
Iiiiia?/oe A.N.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Aiae?c iioae?eiaaieo aeaieo ii oeueo?acaoeia?e
ae?aaiinoeoe? i/ieo caoai?thaaiue iieaco?, ui aiia ?icaeaa?oueny oeyoii
ana a?eueo iiaiiai aeoyao c eoiia?ai e?euee?nii? ?ioi?iaoe?? i?i
aeonoe/i? aeanoeaino? oeaiei (niaeo?aeueiee aiae?c, aeiiiea?ia?ao?y).
Aeei?enoaiiy a?eueo aeineiiaeeo eiii(thoa?eciaaieo oeueo?acaoeiaeo
neaia??a caaacia/o? aeeoa?aioe?thaaiiy ??ciiiai?oieo oei?a
aioo??oiueii/ieo oeaiei, aecia/aiiy oiaueie aioo??oiueii/ieo i?aieiiie,
io?eiaiiy ia(?iiiai cia?aaeaiiy iaoieia?/iiai ooai?aiiy, e?euee?nia
aecia/aiiy oaeaeeino? e?iaiia?ao a ie?aieo noaeeiao iea ? i?a?oe
[Coleman D.J., 1979, 1983, 1990, 1995, Iaoieni?n A.?., 1980, Silverman
R.H., 1995, Guthoff R.F., 1989, 1991].

A?eueo?noue o?aai iea noi?iaiaeaeo?oueny ii?ooaiiyi i?ici?ino?
caeiiethth/eo na?aaeiaeu ia?aaeiueiai a?aeae?eo iea (iaa?ye aai
?io?eueo?aoe?y ?ia?aee, e?ia aai aenoaeao a ia?aaei?e eaia??, iiiooi?iiy
e?eooaeeea), ui oneeaaeith? aai ?iaeoue iaiiaeeeaei ae?aaiinoeeo noaio
neeiaeaeiiai o?ea ? aioo??oiueii/ieo iaieiiie ca aeiiiiiaith iioe/ieo
cania?a aeine?aeaeaiiy.

Iniiaiei oe?iei ?iciianthaeaeaiei caniaii ae?aaiinoeee aioo??oiueii/ii?
iaoieia?? a oeeo aeiaaeeao ? iaeii- ? aeai?ici??ia oeueo?acaoeiaa
aeine?aeaeaiiy [Ia?io? ?. E., 1987, O??aeiai O. ?., 1989].

Iaeiae i?e oaeeo aaaeeeo iinoo?aaiaoe/ieo noaiao iea ye aiaeiooaeuei?o,
ianeaiee aaiiooaeuei, ii/aoeiaa noaae?y noaao?io?? /a?ac aeeoociee
?io?eueo?aoeaiee oa?aeoa? i?ioeano no?oeoo?i? eoiia?ao?/i? ci?ie a
neeiaeaeiiio o?e? iacia/i? aai ? a?aeia?aaeaiiyi noiooiuei? iaoieia??
(a?aeoa?oaaiiy n?oe?aee, iiiooi?iiy neeiaeaeiiai o?ea, aioo??oiueii/ia
noi?iii? o?ei).

A??ia?aeia ae?aaiinoeea aaaeeino? aiaeiooaeuei?oo oa aaiiooaeueio aeoaea
aaaeeeaa. A?aeiii, ui i?e aaaeeiio aiaeiooaeuei?o? oa ianeaiiio
aaiiooaeuei? aoaeoeaia i?iaaaeaia a ?aii? oa?i?ie a?o?aeoii?y [THaeaeia
A.I., 1981, Verbraeken H., 1988, ?iae?i N.N., 1993, Eiaae ?.I., Aia?iaa
I.O., 1985, Aoiaei?iaa ?.A., 1985, Ia/ao?i A.A., Aaeyi?i A.O., 1987,
?iiauaiei A.Ae., 1988]. I?e cao?eioe? c i?iaaaeaiiyi iaiao?aeiiai
e?eoaaiiy ca ei?ioeee /an a?aeaoaathoueny iacai?ioi? aeano?oeoeai? ci?ie
aioo??oi?o iaieiiie iea, ui a a?eueoino? aeiaaee?a i?ecaiaeeoue aei
ao?aoe ia?niaeoea ia ni?eyoeeaee iane?aeie caoai?thaaiiy.

A?aeiii, ui iaea?eueo? o?oaeiiu? a aeeoa?aioe?aeuei?e ae?aaiinoeoe?
iinoo?aaiaoe/ii? a?iioii?? ? noaao?io?? aeeeeeathoue aeiaaeee c
iacia/iei ciaioaiiyi ia?aaeiuei-caaeiuei? in? (ICI) o?aaiiaaiiai iea.
Aiii iiaea aooe coiiaeaii ye ao?aoith neeiaeaeiiai o?ea aai a?iioii??th
aiane?aeie ciaioaiiy i?iaeoeoe?? aiaeyienoi? aieiae ? ca?eueoaiiy ??
a?aeoieo, oae ? aooe ?acoeueoaoii i?ioean?a ao?io??. Aeeoa?aioe?aeueia
ae?aaiinoeea oeeo noai?a ia? aaeeea i?aeoe/ia cia/aiiy, ine?eueee i?e
iinoo?aaiaoe/i?e a?iioii?? aei?aaaeai? oa aoaeoeai? e?eoaaeuei? caoiaee
ii caa?aaeaiith iea ? i?aeaeuaiith eiai ci?iaeo ooieoe?e.

Aeeeaaeai? aeai? aecia/athoue aeooaeuei?noue ?ic?iaee iiaeo a?eueo
aoaeoeaieo cania?a ae?aaiinoeee aaaeeino? iinoo?aaiaoe/iiai
aiaeiooaeuei?oo, aaiiooaeueio oa noaao?io?? i/iiai yaeoea o aeiaaeeao
iiiooi?iiy caeiiethth/eo na?aaeiaeu ia?aaeiueiai a?aeae?eo iea.

Ca(ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?y (
/anoeiith iaoeiai-aeine?aeii? ?iaioe a(aeae(eaiiy ?aeiino?oeoeaii(
i(e?io(?o?a(( iioeiaeaeaiue iea ?inoeoooo IO ? OO ?i. A.I. O?eaoiaa:
«?ic?iaea iiaeo iaoiae?a ae?aaiinoeee ? a?aeiiaethth/iai e?eoaaiiy
oai?eo c oyaeeeie o?aaiaie i/ae» (iiia? aea?ae?a?no?aoe?? UA01002983?),
ui aeeiioaaeany a 1992 — 1995 ?ieao ia aac( ?inoeoooo i/ieo oai?ia ?
oeaieiii? oa?ai?? ?i. A.I. O?eaoiaa.

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe ? i?aeaeuaiiy aoaeoeaiino?
oeueo?acaoeiai? ae?aaiinoeee aaaeeino? aioo??oiueii/ieo iinoo?aaiaoe/ieo
ci?i ia iniia? ?ic?iaee iiaiai iaoiaeo aecia/aiiy oaeaeeino? iioe?aiiiy
oeueo?acaoeo (OIOC) a neeiaeaeiiio o?e?.

Aeey aeinyaiaiiy oe??? iaoe a ?iaio? aoee iinoaaeai? oae? caaea/?:

?ic?iaeoe iiaee niin?a ? i?eno??e aeey aei??thaaiiy oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? iea, aecia/eoe oi/i?noue
cai?iiiiiaaiiai iaoiaeo aeine?aeaeaiiy ? aa??aoe?th oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? a ii?i?.

Aecia/eoe caeaaei?noue oaeaeeino? iioe?aiiy oeueo?acaoeo a?ae
eiioeaio?aoe?? na?aei? oeeo?aoii? e?ia? ? nooi? ieacie e?ia? o
o?c?ieia?/iiio ?ic/ei?.

I?iaanoe ii??aiyeueia aeine?aeaeaiiy ai?noo caaaeueiiai a?eea a
neeiaeaeiiio o?e? i/ae, aioeeaeiaaieo c i?eaiaeo iinoo?aaiaoe/ii?
noaao?io?? i/iiai yaeoea, ? a neeiaeaeiiio o?e? o?oiieo i/ae ethaeae,
ye? ia iaee i/ieo caoai?thaaiue.

Aea/eoe caeaaei?noue aaaeeino? iane?aee?a o?aai iea, oneeaaeiaieo
aiaeiooaeuei?oii /e aaiiooaeueiii, a?ae aaee/eie oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? a ?aiiueiio iinoo?aaiaoe/iiio ia??iae?.

I?iaanoe ii??aiyeueia aeine?aeaeaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo a
neeiaeaeiiio o?e? i?e oneeaaeiaiiyo o?aai iea, ui noi?iaiaeaeothoueny
??ciei nooiaiai ?icaeoeo niieo/ii? oeaieie a neeiaeaeiiio o?e? ?
aioo??oiueii/ieo iaieiieao.

Iaa?oiooaaoe aeioe?euei?noue canoinoaaiiy iaoiaeo aecia/aiiy oaeaeeino?
iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? aeey ioe?iee aaaeeino?
aioo??oiueii/ii? iinoo?aaiaoe/ii? iaoieia?? ? aeaoe ?aeiiaiaeaoe?? uiaei
eiai canoinoaaiiy a eiiieaen? ee?i?/ieo ? ?ino?oiaioaeueieo iaoiae?a
ae?aaiinoeee.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa a iooaeueiieia??
noai?aiee i?eno??e aeey aecia/aiiy in vivo oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? (iaoaio Oe?a?ie ?20886A a?ae 7.10.97) ?
?ic?iaeaia iaoiaeeea aeine?aeaeaiiy, ui aeicaiey? cae?enieoe aei??
oaeaeeino? oeueo?acaoeo c oi/i?noth (1,2 i/n (a?aeiinia iia??oi?noue
(0,08%).

Anoaiiaeaiee aocueeee ae?aiacii aa??aoe?? oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? a ii?i? ( 1541,2(1,6 i/n (M((). Ia
aeyaeaii aeinoia??ii? ?ica?aeiino? i?ae aaee/eiith oaeaeeino? iioe?aiiy
oeueo?acaoeo o ae?oae ? aei?ineeo.

Anoaiiaeaii, ui oaeaee?noue iioe?aiiy oeueo?acaoeo in vitro i?yii
i?iii?oe?eia eiioeaio?aoe?? nooi? ieacie e?ia? oa na?aei? oeeo?aoii?
e?ia? a o?c?ieia?/iiio ?ic/ei?. A?aae??io i?aeaeuaiiy oaeaeeino?
oeueo?acaoeo ia 1% ca?eueoaiiy eiioeaio?aoe?? neeaaea? 3,4 i/n aeey
nooi? ieacie e?ia? e 0,5 i/n aeey e?ia?.

Aia?oa iieacaii, ui i?e aaee/ei? oaeaeeino? iioe?aiiy oeueo?acaoeo a
neeiaeaeiiio o?e? o oai?eo c iinoo?aaiaoe/iei aiaeiooaeuei?oii ?
aaiiooaeueiii iiiaae 1550 i/n a?aecia/athoueny iani?eyoeea? ee?i?/i?
iane?aeee. Iaea?aeai? aeai? aeicaieythoue ?icaeyaeaoe aaee/eio
oaeaeeino? iioe?aiiy oeueo?acaoeo ye aaaeeeaee ianiaoeeo?/iee
ia’?eoeaiee ?ioaa?aeueiee e?euee?niee e?eoa??e aaaeeino? aiaeiooaeuei?oo
? nooiai? aaiiooaeueio.

Aia?oa anoaiiaeaii, ui a neeiaeaeiiio o?e? noaao?io?/ieo i/ae
a?aecia/a?oueny cia/ia i?aeaeuaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo (a
na?aaeiueiio ia 22,3 i/n). Iieacaii, ui oea coiiaeaii ?ic?inoaiiyi
niieo/ii? oeaieie a neeiaeaeiiio o?e? ? aioo??oiueii/ieo iaieiieao,
ine?eueee o?ee?aoia i?aeaeuaiiy ai?noo caaaeueiiai a?eea a neeiaeaeiiio
o?e? noaao?io?/ieo i/ae (aei 0,1%) ia iiaea aeeeeeaoe nooo?aiai
ca?eueoaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo. Aecia/aiee ??aaiue
iieacieea oaeaeeino? iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? ( 1549,2
i/n, yeee aeicaiey? aeae?eeoe noaao?io?/i? i/i? yaeoea ?c i/ae c ?ioeie
iinoo?aaiaoe/ieie ci?iaie (a?iioii?y, oaa?o, iiiooi?iiy neeiaeaeiiai
o?ea, a?aeoa?oaaiiy n?oe?aee).

Iaa?oioiaaia a?aeiinia ia?aaaaa iieacieea oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? o ii??aiyii? c aaee/eiith
ia?aaeiuei-caaeiuei? in? a ae?aaiinoeoe? ii/aoeiai? noaao?io?? i/iiai
yaeoea, yea i?iyaey?oueny nooo?aeie o?a?icieie ci?iaie neeiaeaeiiai o?ea
oa aioo??oiueii/ieo iaieiiie aac cia/iiai ciaioaiiy ?ici???a iea.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Io?eiai? a oiae? aeeiiaiiy
aeena?oaoe?eii? ?iaioe ?acoeueoaoe aeiaiaeyoue, ui aecia/aiiy oaeaeeino?
iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? iieacaii a ?aiiueiio
iinoo?aaiaoe/iiio ia??iae? i?e aiaeiooaeuei?o? oa aaiiooaeuei?, ui
i?io?eathoue c iiiooi?iiyi caeiiethth/eo na?aaeiaeu ia?aaeiueiai
a?aeae?eo iea, c iaoith anoaiiaeaiiy ?o aaaeeino? ? a/aniiai aeai?o i?ae
i?iaeiaaeaiiyi eiina?aaoeaiiai ? o??o?a?/iei caniaaie e?eoaaiiy.
A?aeiii, ui i?e aaaeeiio aiaeiooaeuei?o? oa ianeaiiio aaiiooaeuei?
aoaeoeaia i?iaaaeaia a ?aii? oa?i?ie a?o?aeoii?y.

Iaa?oioiaaia ei?eni?noue aeine?aeaeaiiy oaeaeeino? iioe?aiiy
oeueo?acaoeo a neeiaeaeiiio o?e? i?e an?o iinoo?aaiaoe/ieo ci?iao i/ae
aeey ae?aaiinoeee ii/aoeiai? noaae?? ao?io??, ui i?iyaey?oueny nooo?aeie
o?a?icieie ci?iaie neeiaeaeiiai o?ea oa aioo??oiueii/ieo iaieiiie aac
cia/iiai ciaioaiiy ?ici???a iea.

Aeeoa?aioe?aeueia ae?aaiinoeea iinoo?aaiaoe/ii? a?iioii?? oa noaao?io??
ia? aaeeea i?aeoe/ia cia/aiiy, ine?eueee i?e iinoo?aaiaoe/i?e a?iioii??
aei?aaaeai? ? aoaeoeai? e?eoaaeuei? caoiaee ii caa?aaeaiith iea ?
i?aeaeuaiith eiai ci?iaeo ooieoe?e.

?ic?iaeaiee niin?a aecia/aiiy oaeaeeino? iioe?aiiy oeueo?acaoeo a
neeiaeaeiiio o?e? ai?iaaaeaeaiee o i?aeoe/io ae?aaiinoe/io ?iaioo
a?aeae?eaiiy ?aeiino?oeoeaii? i?e?io??o?a?? iioeiaeaeaiue iea ?
a?aeae?eaiiy a?o?ai?ao?iaeueii? o??o?a?? ?inoeoooo i/ieo oai?ia ?
oeaieiii? oa?ai?? ?i. A.I. O?eaoiaa AII Oe?a?ie, ui aeicaieeei cia/ii
i?aeaeueoe ?ioi?iaoeai?noue oeueo?acaoeiai? ae?aaiinoeee aaaeeino?
aioo??oiueii/ii? iaoieia?? oai?eo c o?aaiaie iea.

Iniiai? iaoeia? ? i?aeoe/i? iieiaeaiiy ?iaioe aeeth/ai? a i?ia?aio
eaeoe?e ? i?aeoe/ieo caiyoue ia?aaeaoanoaoe?eieo oeeee?a eaoaae?e
iooaeueiieia?? oaeoeueoaoo i?neyaeeieiiiiai iaa/aiiy e?ea??a Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. Ia iniia? aea/aiiy e?oa?aoo?e ii
oeueo?acaoeia?e ae?aaiinoeoe? ? naiino?eieo aenia?eiaioaeueieo
aeine?aeaeaiue oai?aoe/ii iaa?oioiaaia iiaeeea?noue ioe?iee aaaeeino?
aioo??oiueii/ieo iinoo?aaiaoe/ieo ci?i i?e oyaeeeo o?aaiao iea oa ?o
iane?aeeao ii aaee/ei? oaeaeeino? iioe?aiiy oeueo?acaoeo a neeiaeaeiiio
o?e?.

Ianoaaeaiiy oai?eo c o?aaiaie iea i?iaaaeaii o a(aeae(eaii(
?aeiino?oeoeaii( i(e?io(?o?a(( iioeiaeaeaiue iea ca o/anoth ae-?a iaae.
iaoe, no. iaoe. ni(a?ia(oieea, ea?(aieea a(aeae(eaiiy E?aniiaeae O.A.

Caeiaoaa/ Eiaaeue/oe I.A. i?eeiaa o/anoue a iooaeueiieia(/iiio
ianoaaeaii? oai?eo, naiino?eii i?ia?a aenia?eiaioaeuei? ? eoiia?ao?/i?
aeine(aeaeaiiy, noaoenoe/io ia?iaeo io?eiaieo ?acoeueoao?a. ?acii ?c
ni?aaaoi?aie aoa c?iaeaiee ee(i(/iee aiae(c aaaeeino? iane?aee?a o?aai
iea o iaoe((io(a a caeaaeiino? a?ae ??aiy i?aeaeuaiiy oaeaeeino?
iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e?.

I??i?eoaoia ?aeay ?ic?iaee i?eeaaeo aeey aecia/aiiy in vivo oaeaeeino?
iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? a iaeiaeia?e i??? iaeaaeeoue
iaoeiaiio ea??aieeia?, ae-?o iaae. iaoe, i?io. Eiaath ?.I., caeiaoaa/o
Eiaaeue/oeo I.A., ae-?o iaae. iaoe, no. iaoe. ni?a?ia?oieeo E?aniiaeae
O.A.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. ?acoeueoaoe aeena?oaoe?? aoee
aeieeaaeai? ia can?aeaiiyo Iaeanueeiai iaeaniiai iooaeueiieia?/iiai
oiaa?enoaa (1999), IO c(?cae? iooaeueiieia?a Oe?a?ie (i. Iaeana, 1996
?.), IV i?aeia?iaei?e eiioa?aioe?? c iooaeueiieia?? (i. Ee?a, 1998 ?.),
ia can?aeaiiyo a/aii? ?aaee ?inoeoooo i/ieo oai?ia ? oeaieiii? oa?ai??
?i. A.I. O?eaoiaa (i. Iaeana, 1996 ( 1998).

Ioae?eaoe??. Iniiai? ?acoeueoaoe aeena?oaoe?? aeeeaaeai? a 7
ioae?eaoe?yo. ?c ieo ( iaeei iaoaio Oe?a?ie, 4 aeo?iaeueieo noaoo? a
“Iooaeueiieia?/iiio aeo?iae?”, oace aeiiia?aeae IX c(?caeo
iooaeueiieia?a Oe?a?ie ? IV i?aeia?iaeii? eiioa?aioe?? c iooaeueiieia??.

Ia(?i oa no?oeoo?a ?iaioe. Aeena?oaoe?y aeeeaaeaia ?in?enueeith iiaith ?
neeaaea?oueny c anooio, 5 ?icae?e?a, caeeth/aiiy, aeniiae?a oa nieneo
aeei?enoaieo e?oa?aoo?ieo aeaea?ae. ?ethno?iaaia 6 oaaeeoeyie ? 23
iaethieaie. Nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae ( 163.

?iaioa aeeeaaeaia ia 129 noi??ieao iaoeiiieno, ?c ieo oaaeeoe?
caeiathoue ( 4, iaethiee ( 8, nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae
( 16 noi??iie.

INIIAIEE CI?NO

Ca inoaii? aeaa aeanyoe??//y a e?oa?aoo?? ? ie?ai? iia?aeiieaiiy i?i
aei?? oaeaeeino? iioe?aiiy oeueo?acaoeo (OIOC) o oeaieiao ethaenueeiai
i?aai?cio c ae?aaiinoe/iith iaoith: iiceo [Kremkau F. W., 1979],
ia/?ioe? [Hayashi N., 1985], o ae?ii/eo a?oaeyo [Kossoff G., 1973].

Aeine?aeaeaiiy OIOC o iaoieia?/ii ci?iaieo no?oeoo?ao iea: a
neeiaeaeiiio o?e? [Caooe?ia I. ?., Iiiiaa-E?eaiiaeiaa E. A., 1991], a
eaoa?aeoaeueieo e?eooaeeeao [Oe?oeeia TH.E., 1984] — iinyoue iaeeie/iee
oa?aeoa? ? i?iaiaeeeeny eeoa in vitro.

Anoaiiaeaii, ui cia/aiiy oaeaeeino? caoea a a?eueoino? a?ieia?/ieo
??aeei ? i’yeeo oeaiei ia?aaeuothoue oaeaee?noue caoea o aiae? ? a?eueo
aeniea cia/aiiy OIOC a iaei?e oeaiei? o ii??aiyii? c ?ioith ei??aeth? c
a?eueo aenieei ai?noii o i?e a?eeia, iniaeeai no?oeoo?iiai eieeaaaia
[Goss S.A., Frizzell L.A., Dunn F., 1980].

Ii aeaiei ??cieo aaoi??a i?e aenia?eiaioaeueiiio aiaeiooaeuei?o? o
e?ie?a e?euee?noue caaaeueiiai a?eea a neeiaeaeiiio o?e? c?inoa? a 6 (
30 ?ac o ii??aiyii? c ii?iith [Walstad R.A., 1987, ?iae?i N.N., 1993].

Ianeai? aaiiooaeueie, ui iinyoue, ye i?aaeei, aeeoociee oa?aeoa?,
iiaeii? aeeeeeaoe i?aeaeuaiiy ??aiy a?eea a neeiaeaeiiio o?e?
i?iii?oe?eii a?aeiiniiio ia’?io e?ia?, ai?no i?ioa?i?a o ye?e a 500
?ac?a aeua ? a?ae??ciy?oueny aeinoaoiueith noaa?euei?noth.

I?e iinoo?aaiaoe/i?e ao?io?? a neeiaeaeiiio o?e? a?aei?/a?oueny
?ic?inoaiiy aaaaoi? eieaaaiii niieo/ii? oeaieie.

Iaaaaeai? aeai? noaee i?aenoaaith aeey ?ic?iaee a iooaeueiieia??
i?eioeeiiai iiaiai i?aeoiaeo a oeueo?acaoeia?e ae?aaiinoeoe?, yeee
aaco?oueny ia aea/aii? ia a?aeaeaieo, a o?aini?n?eieo aeonoe/ieo
oa?aeoa?enoee oeaiei iea.

Aeine?aeaeaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo a ??cieo a?ieia?/ieo
??aeeiao aoee i?iaaaeai? a neeyi?e ethaao?, iii?uai?e a aiaeyiee
oa?iinoao OIN, i?e oaiia?aoo?? 37,0( N.

A aeine?aeaeaiiyo aeei?enoiaoaaeany na?aea oeeo?aoia e?ia ? nooa ieacia
e?ia? o aeaeyae? nooiai ii?ioeo, ui a iaaiiio ni?aa?aeiioaii?
?icaiaeeeeny o?c?ieia?/iei ?ic/eiii.

Ai?no caaaeueiiai a?eea a neeiaeaeiiio o?e? aea/aiee a 8 i/ao,
aioeeaeiaaieo c i?eaiaeo iinoo?aaiaoe/ii? noaao?io??, ? 21 o?oiiiio ioe?
ethaeae, ye? ia iaee i/ieo caoai?thaaiue.

Ee?i?/ia ?ioi?iaoeai?noue iiaiai iaoiaeo oeueo?acaoeiai? ae?aaiinoeee
aea/aia ia 214 oai?eo c aaaeeeie iinoo?aaiaoe/ieie ci?iaie iea: o 42
oai?eo (42 iea) c aino?ei iinoo?aaiaoe/iei aiaeiooaeuei?oii, 30 oai?eo
(30 i/ae) c iinoo?aaiaoe/iei aaiiooaeueiii, 27 oai?eo (27 i/ae) c
noaao?io??th i/iiai yaeoea, 28 oai?eo (28 i/ae) c iinoo?aaiaoe/iith
a?iioii??th, 36 oai?eo (38 i/ae) c iiiooi?iiyi neeiaeaeiiai o?ea, 24
oai?eo (24 iea) c a?aeoa?oaaiiyi n?oe?aee, 28 oai?eo (28 i/ae) c
oaa?oii.

A?eueo?noue oai?eo aoea /ieia?/i? noao? ( 198 (92,5%). Na?aae ieo cia/io
/anoeio neeaaeaee iniae iieiaeiai, iaea?eueo i?aoeacaeaoiiai a?eo (21 (
40 ?ie?a) ( 115 (53.7%)

sse eiio?ieue aoea acyoa oaeaee?noue iioe?aiiy oeueo?acaoeo a
neeiaeaeiiio o?e? a 58 caei?iaeo ia?ieo i/ao oai?eo c aioo??oiueii/ieie
iooeeiaie.

I?e ianoaaeaii? oai?eo canoiniaoaaeenue a?aeii? niiniae ? i?eeaaee ii
caaaeueiii?eeiyo?e iaoiaeeoe?: aino?ioa ci?o aecia/aeany ii oaaeeoeyo
Aieia?ia-N?aoeaaa oa Oaaaeueiaa; canoiniaoaaeenue a?ii?e?ineii?y;
iai?yia iooaeueiineii?y; iaeii?ici??ia oeueo?acaoeiaa eoiia?ao?y
(A-iaoiae) ia eoiiiooaeueiineii? “YIN-22” ? oeueo?acaoeiaiio a?iiao??
“HUMPHREY-820”; aeai?ici??ia oeueo?acaoeiaa neaioaaiiy (A-iaoiae) ia
i?eeaae? “OCUSCAN — 400”.

E??i oiai, an?i oai?ei aoa i?iaaaeaiee aei?? OIOC a neeiaeaeiiio o?e? ca
aeiiiiiaith ?ic?iaeaiiai iaie i?eeaaeo (iaoaio Oe?a?ie ?20886A a?ae
7.10. 97).

I?eeaae aeeiiaiee o aeaeyae? I-iiae?aii? ?icnoaii? neiae, ia iaei?e
aeoaeoe? yei? anoaiiaeaiee aeniei/anoioiee oeueo?acaoeiaee
i?eeiaeueii-aei?ii?ithaaeueiee ia?aoai?thaa/, a ia ?io?e ( aeonoe/iee
a?aeaeaa/. Cacaeaeaa?aeue oeyoii aeaoe?aoii? ?ino?eeyoe?? 0,5% ?ic/eio
ae?ea?ia ?iaeoueny iiaa?oiaaa aianoac?y eii(thieoeaaeueii? ii?iaeieie.
I?ae /an i?iaaaeaiiy aeine?aeaeaiiy neiaa caaiaeeoueny a
eii(thieoeaaeueio ii?iaeieio ia iaeneiaeueii iiaeeeao aeeaeio oaeei
/eiii, uia oeueo?acaoeiaee i?eeiaeueii-aei?ii?ithaaeueiee ia?aoai?thaa/
?icoaooaaany c? ne?iiaai? noi?iie i/iiai yaeoea, a a?aeaeaa/ ( c
iiniai?. Oeyoii ieaaiiai ia?ai?uaiiy ca aeiiiiiaith i?aoeec?eiiai
aeaoooaaiiy aeoaeee I-iiae?aii? ?icnoaii? neiae c oeueo?acaoeiaei
ia?aoai?thaa/ai cae?enith?oueny o?enaoe?y i/iiai yaeoea i?ae a?aeaeaa/ai
? oeueo?acaoeiaei ia?aoai?thaa/ai. A oeeo oiiaao cae?enith?oueny aei??
OIOC a ia?aaei?e iieiaei? neeiaeaeiiai o?ea c canoinoaaiiyi oeeo?iai?
ia?iaee iaea?aeaieo eoiineaiae?a.

Aeine?aeaeaiiy caeiaei e?eueea oaeeei, ia?aiineeiny aeia?a. O?eueee a
aeayeeo aeiaaeeao oai?? nea?aeeeenue ia iai?e?ii? a?ae/oooy a i?noeyo
eiioaeoo i(?ciia?aoai?thaa/a ? aeonoe/iiai a?aeaeaa/a c i/iei yaeoeii.

Aenia?eiaioaeueii anoaiiaeaii, ui e?eaa caeaaeiino? OIOC o
o?c?ieia?/iiio ?ic/ei? a?ae oaiia?aoo?e a ae?aiacii? oaiia?aoo? a?ae 22(
aei 42( N iineoue e?i?eiee oa?aeoa? ? cia/aiiy oaiia?aoo?iiai
eiao?oe?aioa oaeaeeino? (2 i/n/(C) a?aeiia?aea? e?oa?aoo?iei aeaiei. Oea
na?ae/eoue i?i oa, ui cai?iiiiiaaiee i?eeaae i?e ci?i? oaiia?aoo?e
ciai?oiueiai na?aaeiaeua ia aiineoue cia/ieo aeanieo iia??oiinoae a
i?ioean aei??o, ca’ycaieo c oaiia?aoo?ieie i?e?iaeaoi?iaoe?yie eiai
eiino?oeoeaieo aeaiaio?a, ye? iiaeooue aeeeeeaoe ci?io a?aenoai? i?ae
oeueo?acaoeiaei i(?ciia?aoai?thaa/ai ? aeonoe/iei a?aeaeaa/ai.

A ?acoeueoao? aenia?eiaioaeueieo aeine?aeaeaiue onoaiiaeaia i?yia
e?i?eia caeaaei?noue (?(0,05) i?ae aaee/eiith OIOC (i/n) ?
eiioeaio?aoe??th nooi? ieacie e?ia? ? e?ia? N (%) a o?c?ieia?/iiio
?ic/ei?. A?aae??io i?aeaeuaiiy oaeaeeino? oeueo?acaoeo ia 1% ca?eueoaiiy
eiioeaio?aoe?? neeaaea? 3,4 i/n aeey nooi? ieacie e?ia? e 0,5 i/n aeey
e?ia?.

I?iaaaeaieie a?io?i?/ieie aeine?aeaeaiiyie a neeiaeaeiiio o?e?
aioeeaeiaaieo noaao?io?/ieo i/ae aoei aeyaeaii nooo?aa aeinoia??ia
i?aeaeuaiiy ??aiy caaaeueiiai a?eea aei 0,1% ( a na?aaeiueiio a 2,8 ?aca
a?eueoa a?ae ii?ie.

Anoaiiaeaiee a?aeiinii aocueeee ae?aiacii eieeaaiue aaee/eie OIOC a
ii?i? ( a?ae 1537,0 aei 1543,1 i/n (0,4% a?ae na?aaeiueiai cia/aiiy,
??aiiai 1541,2(1,6 (M(()), ui, ia iaoo aeoieo, ? a?aeia?aaeaiiyi aeniei?
noaa?eueiino? o?ceei-eiei?aeieo ia?aiao??a neeiaeaeiiai o?ea.

Aecia/aii, ui aei?? OIOC a neeiaeaeiiio o?e? caei?iaeo i/ae iiaea aooe
c?iaeaiee c oi/i?noth ((1,2(0,2) i/n, ui a?aeiia?aea? a?aeiini?e
iia??oiino? (0,08%.

O an?o 42 oai?eo ia aiaeiooaeuei?o i?e oeueo?acaoeiaiio neaioaaii?
niinoa??aaeinue cia/ia aa??thaaiiy eoiia?ao?/ieo i?eciae?a ii?aaeaiiy
neeiaeaeiiai o?ea ( a?ae eieaeueii ?icoaoiaaieo iaeeie/ieo aeonoe/ii
iecueei? u?eueiino? caouaiue aei oa?aeoa?ieo aeey aiaeiooaeuei?oo
o?eniaaieo ? ieaaath/eo no?oeoo? ??cii? aaee/eie oa aeonoe/ii?
u?eueiino?, ye? /anoi ceeaaeeny a nooe?eueiee eiiaeiia?ao.

OIOC a neeiaeaeiiio o?e? o?aaiiaaiiai iea o oeeo oai?eo aa??thaaea a
oe?ieeo iaaeao: a?ae 1542,3 aei 1574,3 (1555,5(1,3) i/n ? a na?aaeiueiio
ia (14,1(0,3) i/n ia?aaeuoaaea oaeo ia ia?iiio caei?iaiio ioe? (
(1541,3(0,2) i/n.

Aiae?c aeeiai?ee ci?iaeo ooieoe?e ? iane?aee?a aiaeiooaeuei?o?a
aeicaieea aeae?eeoe aea? a?oie oai?eo: a ia?o?e a?oi? c 12 oai?eo, aea
OIOC ia ia?aaeuoaaea 1549,2 i/n, a ??cieoey OIOC ia oai?iio ? ia?iiio
caei?iaiio ioe? aoea iaio 6,8 i/n, iane?aeee a iniiaiiio aeyaeeeny
ni?eyoeeaeie; a ae?oa?e a?oi? c 30 oai?eo, aea OIOC ia?aaeuoaaea 1550,0
i/n, a ??cieoey OIOC ia oai?iio ? ia?iiio caei?iaiio ioe? aoea a?eueoa
8,4 i/n ( iani?eyoeeaeie.

A ia?o?e a?oi? oai?eo ia aoei aeiaeii? aa?noea?aoe?? oa aioeeaaoe??, o 8
iaoe??io?a (67%) a ?acoeueoao? e?eoaaiiy aoa io?eiaiee oi?iaiee c??. A
ae?oa?e a?oi? oai?eo o 15 iaoe??io?a (50%) c i?eaiaeo i?ia?anoaaiiy
aiaeiooaeuei?oo aai noaao?io?? aoea i?iaaaeaia aa?noea?aoe?y aai
aioeeaaoe?y o?aaiiaaiiai iea, na?aae caeeoea oai?eo i? o eiai ia aoei
io?eiaii oi?iaiiai ci?o.

O an?o 30 oai?eo c aaiiooaeueiii i?e oeueo?acaoeiaiio neaioaaii? a
neeiaeaeiiio o?e? aeyaeyeeny aiiiaaii? aeonoe/ii iecueei? u?eueiino?
ae??aiiaeenia?ni? noano?aoe.

OIOC a neeiaeaeiiio o?e? o?aaiiaaiiiai iea o oeeo oai?eo aa??thaaea a?ae
1540,8 aei 1566,3 (1551,2(0,6) i/n ? aoea a na?aaeiueiio ia (10,4(0,7)
i/n aeua, i?ae ia ia?iiio caei?iaiio ieo, aea OIOC neeaea (1541,0(0,2)
i/n.

An?i ?i i?iaiaeeeany eiina?aaoeaia ?icniieooth/a oa?ai?y. Iaeiiio
oai?iio /a?ac aeaa oeaei? i?ney o?aaie aiane?aeie iaaoaeoeaiino?
?icniieooth/i? oa?ai?? aoea i?iaaaeaia a?o?aeoii?y.

Aiae?c aeeiai?ee ci?iaeo ooieoe?e ? iane?aee?a aaiiooaeuei?a aeicaieea
aeae?eeoe aea? a?oie: a ia?o?e a?oi? c 18 oai?eo, aea OIOC ia
ia?aaeuoaaea 1548,4 i/n, a ??cieoey OIOC ia oai?iio oa ia?iiio
caei?iaiio ioe? aoea iaio 7,7 i/n, iane?aeee aeyaeeeny ni?eyoeeaeie; a
ae?oa?e a?oi? c 12 oai?eo, aea OIOC ia?aaeuoaaea 1549,2 i/n, a ??cieoey
OIOC ia oai?iio ? ia?iiio caei?iaiio ioe? aoea a?eueoa 9,2 i/n ( a
iniiaiiio iani?eyoeeaeie.

A ia?o?e a?oi? c 18 oai?eo o 12 iaoe??io?a a i?ioean? e?eoaaiiy aino?ioa
ci?o i?aeaeueeany, o 6 – ia ci?ieeany. A ?acoeueoao? o 15 oai?eo (79%)
aoa io?eiaiee oi?iaiee c?? ? eeoa o o?ueio i?e aeienoe? caa??aaeinue
na?oeia?ae/oooy c i?aaeeueiith aai iai?aaeeueiith na?oeii?iaeoe??th,
ca’ycaia c iaoieia?/ieie ci?iaie a caaeiueiio a?aeae?e? iea. An? oai??
aeienaeeny c niie?eieie i/aie, i? a iaeiiio aeiaaeeo ia a?aei?/aii
a?iioii?? oa oaiaeaioe?? aei ?icaeoeo a?iioii?? iea.

A ae?oa?e a?oi? c 12 oai?eo o 5 in?a ci?ia? ooieoe?? a i?ioean?
e?eoaaiiy ia i?aeaeueeeny, a 6 – iia??oeeeny ? eeoa a iaeiiio aeiaaeeo
aoei a?aei?/aii iie?ioaiiy ? io?eiaii oi?iaiee c??, ??aiee 0,03.
Iaiao?aeii a?aecia/eoe, ui a inoaiiueiio aeiaaeeo oi?ioee ?acoeueoao aoa
aeinyaiooee i?ney noaoioaeueii? a?o?aeoii??, ui aoea i?iaaaeaia a ?aii?
oa?i?ie ( /a?ac 2 oeaei? i?ney io?eiaiiy o?aaie. C 12 oai?eo o 5
iaoe??io?a (42%) ?icaeioeanue noaao?io?y i/iiai yaeoea, c ieo o aeaio
aeiaaeeao a ca’yceo c a(yeiieeiiei oaa?oii i/? aoee aioeeaeiaai?, o 2
iaoe??io?a (17%) ?icaeioeanue no?eea a?iioii?y i/iiai yaeoea, o 1 (8%) (
aoi?eiia aeaoeiia.

Ia iaoo aeoieo, a??o? iane?aeee o?aaiaoe/ieo aiaeiooaeuei?o?a ?
aaiiooaeuei?a i?e aaee/ei? OIOC iiiaae 1549,2 i/n iiaeooue aooe
iia’ycai? c oei, ui i?e iaaiiio ia’?i? caiaeueiiai aenoaeaoa oa
e?iaiaeeeao aeyaeythoueny iaaeinoaoi?ie iiaeeeaino? i?noeaaeo nenoai
aiiainoaca ii ooee?caoe?? i?iaeoeo?a ?iciaaeo oeaiei, aaeoa??aeueieo
oienei?a ? e?ia?. I?e oeueiio a?ieia?/ia a?aeiia?aeue ?icaeaa?oueny o
a?aeiia?aeiino? c caeiiii ia?aoiaeo e?eueeino? a ye?noue: iaaaeee?
caiaeuei? aenoaeaoe oa e?iaiaeeeae ?icniieoothoueny aacne?aeii /e
caeeoathoue i?ney naaa i?aei? iiiooi?iiy, ianeai? ae caiaeuei? aenoaeaoe
oa e?iaiaeeeae ca a?aeiinii ei?ioeee /an i?ecaiaeyoue aei a?oaeo ci?i
neeiaeaeiiai o?ea ? aioo??oiueii/ieo iaieiiie, ia??aeei cae?i/othoueny
noaao?io??th iea.

C?icoi?ei, a iaoiio aeine?aeaeaii? ia iiaeia aeeeth/eoe, ui iaaiee aieea
ia aaaee?noue oa/?? oa iane?aeee o?aaie iea cae?enithaaee oae? oaeoi?e,
ye ?? oa?aeoa?, iayai?noue aioo??oiueii/iiai noi?iiueiai o?ea ? no?iee
eiai aeeo/aiiy, iayai?noue ? ianya a?aeoa?oaaiiy n?oe?aee.

Iacaaaeath/e ia oea, iaea?aeai? aeai? aeicaieythoue aaaaeaoe aaee/eio
OIOC nooo?aei ianiaoeeo?/iei ia’?eoeaiei ?ioaa?aeueiei e?euee?niei
e?eoa???i aaaeeino? aiaeiooaeuei?oo ? aaiiooaeueio.

Oiio aecia/aiiy OIOC a neeiaeaeiiio o?e? i?e aiaeiooaeuei?o? ?
aaiiooaeuei? iieacaia a ?aiiueiio iinoo?aaiaoe/iiio ia??iae? o aeiaaeeao
iiiooi?iiy caeiiethth/eo na?aaeiaeu ia?aaeiueiai a?aeae?eo iea c iaoith
a/aniiai aeai?o i?ae i?iaeiaaeaiiyi eiina?aaoeaiiai oa o??o?a?/iei
iaoiaeaie e?eoaaiiy.

I?e oeueo?acaoeiaiio neaioaaii? o oai?eo ?c iiiooi?iiyi neeiaeaeiiai
o?ea, oaa?oii, a?iioii??th a neeiaeaeiiio o?e? cae/aeii niinoa??aaeeny
aeonoe/ii iecueei? ? na?aaeiuei? u?eueiino? aieieia, oyaee ? oaa?oe. O
oai?eo c a?iioii??th /anoi aeiaeaoeiai a?aecia/aeiny iioiauaiiy
oi??i?aoeiaeueiiai oa?o. O oai?eo c a?aeoa?oaaiiyi n?oe?aee a caaeiueiio
a?aeae?e? iea ia a?eueoiio /e iaioiio i?ioyc? aeyaeyeany oa?aeoa?ia
aeonoe/ii aeniei? u?eueiino? iaia?aiia no?oeoo?a, ui iaea ca’ycie c
aeeneii ci?iaiai ia?ao. O oai?eo c noaao?io??th a neeiaeaeiiio o?e?
niinoa??aaeeny an? aeuacacia/ai? ci?ie a ??cieo eiia?iaoe?yo.

I?e oaa?o?, a?aeoa?oaaii? n?oe?aee, iiiooi?ii? neeiaeaeiiai o?ea,
a?iioii?? aeyaeaii iii??ia (a na?aaeiueiio ia 2,7-4,2 i/n) aeinoia??ia
ca?eueoaiiy OIOC a neeiaeaeiiio o?e? o ii??aiyii? c ii?iith, i?e/iio a
on?o aeiaaeeao iaeneiaeueia cia/aiiy ci??yii? OIOC ia ia?aaeueei 1549,2
i/n. Iaaiaee, aaee/eia OIOC a neeiaeaeiiio o?e? noaao?io?/ieo i/ae
cia/ii (ia 22,3 i/n) ia?aaeueea ii?io (p(0,01), a oaeiae aeinoia??ii
a?ae??ciyeany a?ae na?aaei?o cia/aiue OIOC (p(0,01), io?eiaieo i?e
oaa?o?, iiiooi?ii? neeiaeaeiiai o?ea, a?aeoa?oaaii? n?oe?aee oa
a?iioii??.

Ia i?aenoaa? io?eiaieo ?acoeueoao?a iiaeia noaa?aeaeoaaoe, ui cia/ia
i?aeaeuaiiy OIOC a neeiaeaeiiio o?e? noaao?io?/ieo i/ae ia iiaea aooe
coiiaeaii oaeeie iinoo?aaiaoe/ieie ci?iaie, ye a?iioii?y, oaa?o,
iiiooi?iiy neeiaeaeiiai o?ea, a?aeoa?oaiiy n?oe?aee, a iiynith?oueny
oei, ui a neeiaeaeiiio o?e? oa iaieiieao i/iiai yaeoea ooai?ththoueny
u?euei? o?a?ici? no?oeoo?e, a yeeo oeueo?acaoeia? eieeaaiiy
iioe?ththoueny cia/ii oaeaeoa, i?ae o ii?iaeueiiio neeiaeaeiiio o?e?. A
neeo ia??aiii??iino? ?icaeoeo ? ??ciiai nooiaiy aeyaeaiiy a eiaeiiio
eiie?aoiiio aeiaaeeo o?a?ici? ci?ie iiaeooue aeeeeeaoe ??ciee ??aaiue
i?aeaeuaiiy OIOC.

I?aeaeuaiiy OIOC o neeiaeaeiiio o?e? i?e noaao?io?? i/iiai yaeoea iiaeia
oaeiae iiynieoe ca?eueoaiiyi o neeiaeaeiiio o?e? ai?noo caaaeueiiai
a?eea aiane?aeie o?aaeaiiy aaiaoiiiooaeuei?/iiai aa?’??o, ao?aoe ?i
nai?? aea??eiai? i?iieeiino? ? aeoiaeii eiiiiiaio?a e?ia? c e?iaiiiniiai
?onea ana?aaeeio iea. Iaoeie aeine?aeaeaiiyie anoaiiaeaii ca?eueoaiiy
ai?noo caaaeueiiai a?eea a neeiaeaeiiio o?e? aioeeaeiaaieo noaao?io?/ieo
i/ae aei 0,1%, aea oeueiai i?aeaeuaiiy iaaeinoaoiuei aeey nooo?aiai
ca?eueoaiiy OIOC (ia iao?e a naeoiaeo). Oea iieacaii iaie a
aenia?eiaioaeuei?e ?iaio? ii aea/aiith caeaaeiino? aaee/eie OIOC a?ae
ai?noo nooi? ieacie e?ia? a o?c?ieia?/iiio ?ic/ei?.

Iaie aeyaeaiee aenieee ??aaiue ei?aeyoe?eii? caeaaeiino? (r=0,68) OIOC o
neeiaeaeiiio o?e? a?ae nooiaiy ciaioaiiy aeiaaeeie iea. I?ioa aeaeaei ia
caaaeaee ciaioaiiy ia?aaeiuei-caaeiuei? in? iaeiicia/ii
noi?iaiaeaeoaaeiny i?aeaeuaiiyi OIOC. Aaee/eia ei?aeyoe?eiiai ca’yceo
i?ae OIOC o neeiaeaeiiio o?e? ? nooiaiai ciaioaiiy aeiaaeeie iea ??cei
cieaeo?oueny (aei r=0,19) ? aiia noa? iaaeinoia??iith o aeiaaeeao
iacia/iiai ciaioaiiy (aei 15%) ?ici??o o?aaiiaaiiiai iea o ii??aiyii? c
ia?iei caei?iaei. Oea iiaeia iiynieoe oei, ui o a?eueoino? aeiaaee?a a
oeeo i/ao ua ia ii/aany i?ioean cai?uaiiy o?a?iciith oeaieiith
o?c?ieia?/ii aeoeaieo no?oeoo?, a iaea i?noea ao?aoa neeiaeaeiiai o?ea
/e a?iioii?y.

Iieaciee OIOC a neeiaeaeiiio o?e? ia? a?aeiinio ia?aaaao o ii??aiyii? c
aaee/eiith ICI a ae?aaiinoeoe? ii/aoeiai? noaao?io?? i/iiai yaeoea, ui
i?iyaey?oueny nooo?aeie o?a?icieie ci?iaie neeiaeaeiiai o?ea ?
aioo??oiueii/ieo iaieiiie aac cia/iiai ciaioaiiy ?ici???a iea. Oea
coiiaeaii oei, ui ca eiai aeiiiiiaith ioe?ith?oueny nooi?iue ?ic?inoaiiy
niieo/ii? oeaieie a ioe? ( iaoiaaiaoe/ii a?eueo ?aii?e i?iya ao?io??,
i?ae ciaioaiiy ?ici??o i/iiai yaeoea.

Iieaciee OIOC ii oa?aeoa?o ci?i, ye? aea/athoueny ? ioe?iththoueny,
nooo?ai caeeaea? oae? iiiyooy ye “ao?io?y” a a?noieia?? ? “noaao?io?y” a
ee?i?oe?. Ie aaaaea?ii, ui aeine?aeaeaiiy OIOC o neeiaeaeiiio o?e? iiaea
aooe ei?eniei i?e an?o iinoo?aaiaoe/ieo noaiao i/ae ?c ciaioaiiyi
ia?aaeiuei-caaeiuei? in? aeey ae?aaiinoeee ianooio ao?io??.

Iaiao?aeii a?aecia/eoe ?yae iniaeeainoae cai?iiiiiaaiiai ia’?eoeaiiai
e?euee?niiai iieacieea. Ii-ia?oa, ye iieacaii a ?iaio?, a?i iineoue
ianiaoeeo?/iee (oi?aa?naeueiee) oa?aeoa? ? eiai aaee/eia a iniiaiiio
aecia/a?oueny ai?noii o neeiaeaeiiio o?e? caaaeueiiai a?eea iacaeaaeii
a?ae eiai iioiaeaeaiiy. Ii-ae?oaa, oeae iieaciee yaey? niaith
?ioaa?aeueiee (noia?iee) e?eoa??e nooiaiy aeeoocieo ci?i o neeiaeaeiiio
o?e?, ai a?aeaeaa? eiai iaoieia?th a ia’?i?.

Aaaeeeaei ?acoeueoaoii i?iaaaeaieo aeine?aeaeaiue ? anoaiiaeaiiy aeey
an?o aea/aieo iinoo?aaiaoe/ieo noai?a iea, ui nooo?ai a?ae??ciythoueny
ii oa?aeoa?o iaoieia?/ieo ci?i, iaeiaeiaiai a?aie/ii aeiionoeiiai ??aiy
OIOC a neeiaeaeiiio o?e? (1549,2-1550,0 i/n), ia?aaeuaiiy yeiai, ye
i?aaeei, na?ae/eoue i?i iani?eyoeeaee ?icaeoie caoai?thaaiiy.

A?aoiaoth/e aenieo ae?aaiinoe/io oe?ii?noue aaee/eie OIOC a ianoaaeaii?
oai?eo c aeeoociith iaoieia??th neeiaeaeiiai o?ea i?e iiiooi?ii?
caeiiethth/eo na?aaeiaeu ia?aaeiueiai a?aeae?eo iea, aeioe?eueii
?aeiiaiaeoaaoe ai?iaaaeaeaiiy niiniao aecia/aiiy OIOC o neeiaeaeiiio
o?e? ye aeiaeaoeiaiai ?aaeeio ?iaioe a ?nioth/? iooaeueiieia?/i?
i?eeaaee aeey oeueo?acaoeiai? a?iiao???. I?aeoe/ii oea eeoa iio?aao?
?ic?iaee aeiaeaoeiaiai aeniei/anoioiiai oeueo?acaoeiaiai aeao/eea ?
niaoe?aeueii? i?ia?aie aeey ia?iaee a?aeaeoeo eoiineaiae?a.

AENIIAEE

Oeueo?acaoeiaa ae?aaiinoeea i/ieo caoai?thaaiue ?icaeaa?oueny a noi?iio
a?eueo iiaiiai aeoyao e?euee?nii? ?ioi?iaoe?? c eoiineaiia?ai
(niaeo?aeueiee aiae?c, aeiiiea?ia?ao?y). A?aenooi?noue ia?iaaceaieo
iaoiae?a ia(?eoeaii? e?euee?nii? ioe?iee aaaeeino? aioo??oiueii/ieo
iinoo?aaiaoe/ieo ci?i o aeiaaeeao iiiooi?iiy caeiiethth/eo na?aaeiaeu
ia?aaeiueiai a?aeae?eo iea oneeaaeith? a/aniee aea?? aaeaeaaoieo
iaoiae?a e?eoaaiiy iinoo?aaiaoe/iiai aiaeiooaeuei?oo, aaiiooaeueio oa
noaao?io?? i/iiai yaeoea, ui coiiaeth? a??o? iane?aeee o?aai iea.

Aia?oa a iooaeueiieia?? noai?aiee i?eno??e aeey aecia/aiiy in vivo
oaeaeeino? iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? (iaoaio Oe?a?ie
?20886A a?ae 7.10.97) ? ?ic?iaeaia iaoiaeeea aeine?aeaeaiiy, ui
aeicaiey? cae?enieoe aei?? oaeaeeino? oeueo?acaoeo c oi/i?noth (1,2 i/n
(a?aeiinia iia??oi?noue (0,08%).

Oaeaee?noue iioe?aiiy oeueo?acaoeo in vitro i?yii i?iii?oe?eia
eiioeaio?aoe?? nooi? ieacie e?ia? oa na?aei? oeeo?aoii? e?ia? a
o?c?ieia?/iiio ?ic/ei?. A?aae??io i?aeaeuaiiy oaeaeeino? oeueo?acaoeo ia
1% ca?eueoaiiy eiioeaio?aoe?? neeaaea? 3,4 i/n aeey nooi? ieacie e?ia? e
0,5 i/n aeey e?ia?.

Oaeaee?noue iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? a ii?i? ia?
aocueeee ae?aiacii aa??aoe?? ( 1541,2(1,6 i/n (M((). Ia anoaiiaeaii
aeinoia??ii? ?ica?aeiino? i?ae aaee/eiith oaeaeeino? iioe?aiiy
oeueo?acaoeo o ae?oae ? aei?ineeo.

Aia?oa iieacaii, ui i?e aaee/ei? oaeaeeino? iioe?aiiy oeueo?acaoeo a
neeiaeaeiiio o?e? o oai?eo c iinoo?aaiaoe/iei aiaeiooaeuei?oii ?
aaiiooaeueiii iiiaae 1550 i/n a?aecia/athoueny iani?eyoeea? ee?i?/i?
iane?aeee. Io?eiai? aeai? aeicaieythoue ?icaeyaeaoe aaee/eio oaeaeeino?
iioe?aiiy oeueo?acaoeo ye aaaeeeaee ianiaoeeo?/iee ia’?eoeaiee
?ioaa?aeueiee e?euee?niee e?eoa??e aaaeeino? aiaeiooaeuei?oo ? nooiaiy
aaiiooaeueio.

Aia?oa anoaiiaeaii, ui a neeiaeaeiiio o?e? noaao?io?/ieo i/ae
a?aecia/a?oueny cia/ia i?aeaeuaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo (a
na?aaeiueiio ia 22,3 i/n). Iieacaii, ui oea coiiaeaii ?ic?inoaiiyi
niieo/ii? oeaieie a neeiaeaeiiio o?e? ? aioo??oiueii/ieo iaieiieao,
ine?eueee o?ee?aoia i?aeaeuaiiy ai?noo caaaeueiiai a?eea a neeiaeaeiiio
o?e? noaao?io?/ieo i/ae (aei 0,1%) ia iiaea aeeeeeaoe nooo?aiai
ca?eueoaiiy oaeaeeino? iioe?aiiy oeueo?acaoeo. Aecia/aiee ??aaiue
iieacieea oaeaeeino? iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? ( 1549,2
i/n, yeee aeicaiey? aeae?eeoe noaao?io?/i? i/i? yaeoea ?c i/ae c ?ioeie
iinoo?aaiaoe/ieie ci?iaie (a?iioii?y, oaa?o, iiiooi?iiy neeiaeaeiiai
o?ea, a?aeoa?oaaiiy n?oe?aee).

?acoeueoaoe ee?i?/ii? ai?iaaoe?? cai?iiiiiaaiiai i?eeaaeo ? niiniao
aecia/aiiy oaeaeeino? iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e?
aeicaieythoue ?aeiiaiaeoaaoe eiai ye aeiaeaoeiaee ?ino?oiaioaeueiee
iaoiae aeine?aeaeaiiy a eiiieaeni?e ae?aaiinoeoe? aaaeeino? na?aeeo
o?aai iea oa ?o iane?aee?a.

NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??

Eiaaeue/oe A.A. Ii?aaeaeaiea nei?inoe ?ani?ino?aiaiey oeueo?acaoea a
noaeeiaeaeiii oaea i?e iinoo?aaiaoe/aneeo, ainiaeeoaeueiuo e iiooieaauo
aeaciuo caaieaaaieyo //Iooaeueiie. aeo?i. — 1997. — ?1. — N. 56-61.

Eiaae E.I., Eiaaeue/oe A.A., E?aniiaeae O.A. Iiaue yeni?ann-iaoiae
oeueo?acaoeiaie aeeaaiinoeee oyaeanoe ino?iai iinoo?aaiaoe/aneiai
yiaeiooaeueieoa //Iooaeueiie. aeo?i. — 1997. — ?3. — N. 153-157.

Eiaae E.I., Eiaaeue/oe A.A., E?aniiaeae O.A. Oeueo?acaoeiaay
aeeaaiinoeea oyaeanoe aaiiooaeueia a ?aiiai iinoo?aaiaoe/aneii ia?eiaea
//Iooaeueiie. aeo?i. — 1998. — ?4. — N. 302-306.

Eiaaeue/oe A.A., E?aniiaeae O.A., Eieiiee/oe N.A. Oeueo?acaoeiaie
eiee/anoaaiiue iaoiae ioeaiee au?aaeaiiinoe aioo?eaeaciuo oea?iciuo
eciaiaiee i?e iinoo?aaiaoe/aneie noaao?ioee aeaciiai yaeiea
//Iooaeueiie. aeo?i. — 1998. — ?6. — N. 441-447.

Iao. ?20886A Oe?a?ia, IIE 6 A61A8/10. I?eno??e aeey aei??thaaiiy
oaeaeeino? iioe?aiiy oeueo?acaoeo o a?ieia?/ieo oeaieiao /Eiaae ?.I.,
Eiaaeue/oe I.A., E?aniiaeae O.A.; Cayaa ?96072825 15.07.96; Iioae.
27.02.98; Athe. ?1; N.3.1.42-3.1.43.

Eiaae E.I., Eiaaeue/oe A.A., E?aniiaeae O.A. Iiaue oeueo?acaoeiaie
iaoiae ioeaiee oyaeanoe yiaeiooaeueieoa e aaiiooaeueia a ?aiiea n?iee
iinea o?aaiu //Oace aeii. IO c(?caeo iooaeueiieia?a Oe?a?ie. ( Iaeana. —
1996. — N.310-311.

Eiaaeue/oe A.A., E?aniiaeae O.A., Eieiiee/oe N.A. Eiee/anoaaiiue iaoiae
ioeaiee noaiaie au?aaeaiiinoe aioo?eaeaciuo iinoo?aaiaoe/aneeo oea?iciuo
eciaiaiee //Oace aeii. IV i?aeia?iaeii? eiioa?aioe?? c iooaeueiieia??. —
Ee?a. — 1998. — N.157-158.

AIIOAOe?ss

Eiaaeue/oe I.A. Oaeaee?noue iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e?
iea ye ae?aaiinoe/iee iieaciee nooiaiy aioo??oiueii/ieo iinoo?aaiaoe/ieo
ci?i. ( ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.18 ( i/i? oai?iae. ( ?inoeooo i/ieo oai?ia ?
oeaieiii? oa?ai?? ?i. A.I. O?eaoiaa, AII Oe?a?ie, Iaeana, 1999.

Aaoi?ii cai?iiiiiaaiee iiaee e?euee?niee iaoiae oeueo?acaoeiai?
ae?aaiinoeee aaaeeino? aioo??oiueii/ieo iinoo?aaiaoe/ieo ci?i (iaoaio
Oe?a?ie ?20886A a?ae 7.10.97) i?e oyaeeeo o?aaiao iea oa ?o iane?aeeao
ia i?aenoaa? aecia/aiiy oaeaeeino? iioe?aiiy oeueo?acaoeo (OIOC) a
neeiaeaeiiio o?e?. Ianoaaeaii 214 oai?eo (214 i/ae) c iinoo?aaiaoe/iei
aiaeiooaeuei?oii, aaiiooaeueiii, noaao?io??th i/iiai yaeoea,
a?iioii??th, oaa?oii, iiiooi?iiyi neeiaeaeiiai o?ea, a?aeoa?oaaiiyi
n?oe?aee. A on?o aeiaaeeao aeyaeaii aeinoia??ia i?aeaeuaiiy OIOC o
neeiaeaeiiio o?e? o ii??aiyii? c ii?iith. Iieacaii, ui i?aeaeuaiiy OIOC
a iniiaiiio coiiaeaii ca?eueoaiiyi a neeiaeaeiiio o?e? ai?noo
caaaeueiiai a?eea. Aia?oa anoaiiaeaii, ui i?e aaee/ei? OIOC o
neeiaeaeiiio o?e? iiiaae 1550 i/n o oai?eo c iinoo?aaiaoe/iei
aiaeiooaeuei?oii ? aaiiooaeueiii a?aecia/athoueny iani?eyoeea? ee?i?/i?
iane?aeee. A neeiaeaeiiio o?e? noaao?io?/ieo i/ae aeyaeaii cia/ia
i?aeaeuaiiy OIOC (a na?aaeiueiio ia 22,3 i/n) ? iieacaii, ui aiii
coiiaeaii ?ic?inoaiiyi aaaaoi? eieaaaiii niieo/ii? oeaieie a
neeiaeaeiiio o?e? oa aioo??oiueii/ieo iaieiieao. ??aaiue iieacieea
oaeaeeino? iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e? 1549,2 i/n ? aeua
aeicaiey? aeae?eeoe noaao?io?/i? i/i? yaeoea ?c i/ae c ?ioeie
iinoo?aaiaoe/ieie ci?iaie (a?iioii?y, oaa?o, iiiooi?iiy neeiaeaeiiai
o?ea, a?aeoa?oaaiiy n?oe?aee).

Eeth/ia? neiaa: o?aaia iea, neeiaeaeia o?ei, oeueo?acaoeiaa
ae?aaiinoeea, oaeaee?noue iioe?aiiy oeueo?acaoeo a neeiaeaeiiio o?e?.

AIIIOAOeEss

Eiaaeue/oe A.A. Nei?inoue ?ani?ino?aiaiey oeueo?acaoea a noaeeiaeaeiii
oaea aeaca eae iieacaoaeue noaiaie aioo?eaeaciuo iinoo?aaiaoe/aneeo
eciaiaiee. ( ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.18 ( aeaciua aieacie. ( Einoeooo aeaciuo
aieaciae e oeaiaaie oa?aiee ei. A.I. Oeeaoiaa, AII Oe?aeiu, Iaeanna,
1999.

Oeueo?acaoeiaay aeeaaiinoeea aeaciuo caaieaaaiee ?acaeaaaony a noi?iio
ana aieaa iieiiai ecaea/aiey ec yoineaiia?aii eiee/anoaaiiie eioi?iaoeee
ia aeonoe/aneeo naienoaao oeaiae (niaeo?aeueiue aiaeec,
aeiiiea?ia?aoey). Ionoonoaea iaeiaaceaiuo iaoiaeia iauaeoeaiie
eiee/anoaaiiie ioeaiee oyaeanoe aioo?eaeaciuo iinoo?aaiaoe/aneeo
eciaiaiee a neo/ayo iiiooiaiey i?aeiieythueo n?aae ia?aaeiaai ioaeaea
aeaca cao?oaeiyao naiaa?aiaiiue auai? aaeaeaaoiuo iaoiaeia ea/aiey
iinoo?aaiaoe/aeiai yiaeiooaeueieoa, aaiiooaeueia e noaao?ioee aeaciiai
yaeiea, /oi iaoneaaeeaaao ooaeoea enoiaeu o?aai aeaca. Aaoi?ii
ipaaeeiaeai iiaue eiee/anoaaiiue iaoiae oeueo?acaoeiaie aeeaaiinoeee
au?aaeaiiinoe aioo?eaeaciuo iinoo?aaiaoe/aneeo eciaiaiee (iaoaio Oe?aeiu
?20886A io 7.10.97) i?e oyaeaeuo o?aaiao aeaca e eo enoiaeao ia iniiaa
iipaaeaeaiey nei?inoe ?ani?ino?aiaiey oeueo?acaoea (N?OC) a
noaeeiaeaeiii oaea. I?e aiaeeca eeoa?aoo?u auyniaii, /oi cia/aiey
nei?inoe caoea a aieueoeinoaa aeieiae/aneeo aeeaeeinoae e iyaeeo oeaiae
i?aauoatho nei?inoue caoea a aiaea e aieaa aunieia cia/aiea N?OC a
iaeiie oeaie ii n?aaiaieth n ae?oaie ei??aee?oao n aieaa aunieei
niaea?aeaieai a iae aaeeia, a iniaaiiinoe no?oeoo?iiai eieeaaaia. I?e
iinoo?aaiaoe/aneii yiaeiooaeueieoa a noaeeiaeaeiii oaea iaeaieeaaaony
aiaaoue aaeeii ainiaeeoaeueiue yennoaeao, i?e aaiiooaeueia a
noaeeiaeaeiia oaei iiiaaeaao e?iaue, niaea?aeaiea aaeea a eioi?ie a 500
?ac auoa. I?e iinoo?aaiaoe/aneie noaao?ioee aeaciiai yaeiea a
noaeeiaeaeiii oaea e aioo?eaeaciuo iaiei/eao ioia/aaony ?ac?anoaiea
oea?iciie niaaeeieoaeueiie oeaie. I?eaaaeaiiua aeaiiua iineoaeeee
iniiaie aeey ?ac?aaioee iiaiai iaoiaea oeueo?acaoeiaie aeeaaiinoeee.
Yenia?eiaioaeueiuie enneaaeiaaieyie in vitro onoaiiaeaii, /oi nei?inoue
?ani?ino?aiaiey oeueo?acaoea i?yii i?iii?oeeiiaeueia eiioeaio?aoeee
nooie ieaciu e?iae e e?iae a oeceieiae/aneii ?anoai?a. A?aaeeaio
iiauoaiey nei?inoe ?ani?ino?aiaiey oeueo?acaoea ia 1% oaaee/aiey
eiioeaio?aoeee ninoaaeyao 3,4 i/n aeey nooie ieaciu e?iae e 0,5 i/n aeey
e?iae. Aeioeie/aneeie enneaaeiaaieyie a noaeeiaeaeiii oaea
yioeeae?iaaiiuo noaao?ioe/iuo aeac auyaeaii aeinoiaa?iia iiauoaiea
niaea?aeaiey iauaai aaeea aei 0,1% (a eiio?ieueiuo aeacao yoio
iieacaoaeue ninoaaee 0,035%), eioi?ia ia iiaeao aucaaoue nouanoaaiiiai
oaaee/aiey nei?inoe ?ani?ino?aiaiey oeueo?acaoea. Onoaiiaeaii, /oi
nei?inoue ?ani?ino?aiaiey oeueo?acaoea a noaeeiaeaeiii oaea iiaeao auoue
ecia?aia n oi/iinoueth (1,2 i/n (ioiineoaeueiay iia?aoiinoue (0,08%). Ia
58 caei?iauo aeacao ii?aaeaeaii, /oi nei?inoue ?ani?ino?aiaiey
oeueo?acaoea a noaeeiaeaeiii oaea a ii?ia eiaao oceee aeeaiacii
aa?eaoeee ( 1541,2(1,6 i/n (I((). Ianeaaeiaaii 214 aieueiuo (214 aeac) n
iinoo?aaiaoe/aneei yiaeiooaeueieoii, aaiiooaeueiii, noaao?ioeae aeaciiai
yaeiea, aeiioiieae, oaaeoii, iiiooiaieai noaeeiaeaeiiai oaea, ioneieeie
nao/aoee. I?e anao aeaeao iaoieiaee iaia?oaeaii aeinoiaa?iia iiauoaiea
N?OC a noaeeiaeaeiii oaea ii n?aaiaieth n ii?iie. Aia?aua onoaiiaeaii,
/oi i?e aaee/eia N?OC a noaeeiaeaeiii oaea aieaa 1550 i/n o aieueiuo n
iinoo?aaiaoe/aneei yiaeiooaeueieoii e aaiiooaeueiii ioia/athony
iaaeaaii?eyoiua eeeie/aneea enoiaeu, /oi iicaieyao ?anniao?eaaoue
aaee/eio N?OC eae aaaeiue ianiaoeeoe/aneee iauaeoeaiue eioaa?aeueiue
eiee/anoaaiiue e?eoa?ee oyaeanoe yiaeiooaeueieoa e noaiaie aaiiooaeueia.
I?e oaaeoa, ioneieea nao/aoee, iiiooiaiee noaeeiaeaeiiai oaea, aeiioiiee
iaia?oaeaii oia?aiiia (a n?aaeiai ia 2,7 ( 4,2 i/n) aeinoiaa?iia
oaaee/aiea N?OC a noaeeiaeaeiii oaea ii n?aaiaieth n ii?iie, i?e/ai ai
anao neo/ayo iaeneiaeueiia cia/aiea ecia?aiiie N?OC ia i?aauneei 1549,2
i/n. A a?oiia aieueiuo n noaao?ioeae aaee/eia N?OC a noaeeiaeaeiii oaea
cia/eoaeueii (ia 22,3(2,2 i/n) i?aauneea ii?io (?(0,01), a oaeaea
aeinoiaa?ii ioee/aeanue io n?aaeieo cia/aiee N?OC (?(0,01), iieo/aiiuo
i?e oaaeoa, iiiooiaiee noaeeiaeaeiiai oaea, ioneieea nao/aoee e
aeiioiiee. Iieacaii, /oi cia/eoaeueiia iiauoaiea N?OC a noaeeiaeaeiii
oaea noaao?ioe/iuo aeac iaoneiaeaii ?ac?anoaieai aiaaoie eieeaaaiii
niaaeeieoaeueiie oeaie a noaeeiaeaeiii oaea e aioo?eaeaciuo iaiei/ae,
iineieueeo o?aoe?aoiia iiauoaiea niaea?aeaiey iauaai aaeea a
noaeeiaeaeiii oaea noaao?ioe/iuo aeac (aei 0,1%) ia iiaeao aucaaoue
nouanoaaiiiai oaaee/aiey nei?inoe ?ani?ino?aiaiey oeueo?acaoea. O?iaaiue
iieacaoaey N?OC a noaeeiaeaeiii oaea 1549,2 i/n e auoa iicaieyao
auaeaeeoue noaao?ioe/iua aeaca ec aeac n ae?oaeie iinoo?aaiaoe/aneeie
eciaiaieyie (aeiioiiey, oaaeo, iiiooiaiea noaeeiaeaeiiai oaea, ioneieea
nao/aoee). Yoio iieacaoaeue ii oa?aeoa?o eco/aaiuo e ioeaieaaaiuo
eciaiaiee nouanoaaiii naeeaeaao oaeea iiiyoey, eae “ao?ioey” a
ii?oieiae/aneii e “noaao?ioey” a eeeie/aneii iiieiaiee. Iieacaoaeue N?OC
a noaeeiaeaeiii oaea iaeaaeaao i?aeiouanoaii ii n?aaiaieth n aaee/eiie
ICI a aeeaaiinoeea ia/aeueiie noaao?ioee aeaciiai yaeiea, i?iyaeythuaeny
au?aaeaiiuie oea?iciuie eciaiaieyie noaeeiaeaeiiai oaea e aioo?eaeaciuo
iaiei/ae aac cia/eoaeueiiai oiaiueoaiey ?acia?ia aeaca. Yoi iaoneiaeaii
oai, /oi n aai iiiiuueth ioeaieaaaony noaiaiue ?ac?anoaiey
niaaeeieoaeueiie oeaie a aeaco ( iaoiaaiaoe/anee aieaa ?aiiaa i?iyaeaiea
ao?ioee, /ai oiaiueoaiea ?acia?a aeaciiai yaeiea. ?acoeueoaou
eeeie/aneie ai?iaaoeee i?aaeeiaeaiiiai ono?ienoaa e niiniaa ii?aaeaeaiey
nei?inoe ?ani?ino?aiaiey oeueo?acaoea a noaeeiaeaeiii oaea iicaieytho
?aeiiaiaeiaaoue aai a ea/anoaa aeiiieieoaeueiiai eino?oiaioaeueiiai
iaoiaea enneaaeiaaiey a eiiieaeniie aeeaaiinoeea oyaeanoe naaaeeo o?aai
aeaca e eo enoiaeia

Eeth/aaua neiaa: o?aaia aeaca, noaeeiaeaeiia oaei, oeueo?acaoeiaay
aeeaaiinoeea, nei?inoue ?ani?ino?aiaiey oeueo?acaoea a noaeeiaeaeiii
oaea.

ANNOTATION

Kovalchuk A.G. Ultrasound velocity in vitreous body as diagnostic
indicator of the severity of intraocular posttraumatic changes. (
Manuscript.

Thesis for a candidate`s degree by speciality 14.01.18 ( eye diseases. (
The Filatov Institute of Eye Diseases and Tissue Therapy, AMS of
Ukraine, Odessa, 1999.

The author has developed a new quantitative method of ultrasonic
diagnostics for evaluation of the severity of intraocular posttraumatic
changes (patent of Ukraine ?20886A of 7.10.97) in cases of heavy eye
trauma based on the measurement of ultrasound velocity (USV) in vitreous
body. 214 patients (214 eyes) with posttraumatic endophthalmitis,
hemophthalmos, phthisis oculi, hypotony, vitreous opacity, uveitis,
retinal detachment have been inspected. In all cases the considerable
USV rise on comparison with the norm is revealed. It is shown, that the
USV rise is caused mainly by increasing of common protein content. For
the first time it is established, that unfavorable clinical outcomes are
marked at patients with posttraumatic endophthalmitis and hemophthalmos
when USV in vitreous body increase more than 1550 m/s. In cases of
posttraumatic phthisis oculi the significant USV rise (on the average
22,3 m/s) is revealed and it is shown, that it is caused by growth of
connective tissue in vitreous body and eye`s sheaths, which contains
significant amount of collagen. The USV in vitreous body 1549,2 m/s and
above allows to differentiate posttraumatic phthisis oculi from other
posttraumatic changes (posttraumatic hypotony, vitreous opacity,
uveitis, retinal detachment).

Key words: eye trauma, vitreous body, ultrasonic diagnostics, ultrasound
velocity in vitreous body.

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