Розробка складу та технології противиразкового препарату у вигляді гранул на основі природного цеоліту: Автореф. дис… канд. фармац. наук / Т.В. Крут

OE?A?INUeEA OA?IAOeAAOE*IA AEAAeAI?ss

E?OONUeEEO OAOssIA AANEE?AIA

OAeE 615.453.3:616.33-002.44:549.67

?IC?IAEA NEEAAeO OA OAOIIEIA?? I?IOEAE?ACEIAIAI I?AIA?AOO O AEAEssAe?
A?AIOE IA INIIA? I?E?IAeIIAI OeAIE?OO

15.00.01. Oaoiieia?y e?e?a oa i?iieneiaa oa?iaoe?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa oa?iaoeaaoe/ieo iaoe

Oa?e?a-1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Oe?a?inuee?e oa?iaoeaaoe/i?e aeaaeai?? (i. Oa?e?a)
I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? Oa?iaoeaaoe/ieo iaoe, i?ioani?

*o?oia Aeaaeeneaa ?aaiiae/

Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y,

caa?aeoth/ee eaoaae?ith caaiaenueei? oaoiieia?? e?e?a

Io?oe?ei? iiiiaioe:

aeieoi? oa?iaoeaaoe/ieo iaoe, i?ioani?

Aeieo???anueeee Aeieo?i ?aaiiae/

Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y,

caa?aeoth/ee eaoaae?ith i?aai?caoe?? oa aeiiii?ee oa?iaoe??;

aeieoi? oa?iaoeaaoe/ieo iaoe, aeioeaio

Aeaaeeoaa A?oae?e Aaeaioeiiae/

Caii??cueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

aeioeaio eaoaae?e oaoiieia?? e?e?a.

I?ia?aeia onoaiiaa:

Aea?aeaaiee iaoeiaee oeaio? e?ea?nueeeo cania?a, a?aeae?e oaaeaoiaaieo
e?ea?nueeeo oi?i, i. Oa?e?a.

Caoeno aeena?oaoe?? a?aeaoaeaoueny “30” aa?aniy 1999 ?. i 15 aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? A/aii? ?aaee Ae 64.605.01 i?e Oe?a?inuee?e
oa?iaoeaaoe/i?e aeaaeai?? ca aae?anith: 310002 i. Oa?e?a, aoe.
Iooe?inueea, 53.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oe?a?inueei?
oa?iaoeaaoe/ii? aeaaeai?? (310168, i.Oa?e?a, aoe. Aethoa?a, 4)

Aaoi?aoa?ao ?ic?neaiee “_28_” na?iiy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? A/aii? ?aaee A?eoeaiei ?.N.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ca inoaii? 15 ?ie?a ?iciianthaeaeai?noue
ae?aceiai? oai?iae oeoieiai — eeoeiaiai o?aeoo (OEO) na?aae ianaeaiiy
Oe?a?ie c?inea a 2,2 ?ace. Ca aeaieie i?iaiic?a, ?ic?aoiaaieo iaoiaeii
aeno?aiieyoe?e, i?e caa?aaeaii? oaiaeaioe?e oa oiia, ye? neeaeeny ca
ieioe? ?iee, /enei aeiaaee?a ae?aceiai? oai?iae OEO c?inoa aei 2010 ?ieo
aei 1934,59 ( 92,9 ia 100 000 iaoeaioe?a iaoi? e?a?ie (ca?ac oeae
iieaciee neeaaea? 1335,8 ia noi oeny/ ianaeaiiy).

Oaeei /eiii, iaaaaeai? aeai? i?i ?iciianthaeaeai?noue oe??? oai?iae oa
?? i?iaiic na?ae/aoue i?i aeeiai?/iee i?ia?anoth/ee c??no /enea
aeiaaee?a aeacaii? iaoieia??.

Aeey e?eoaaiiy aeaieo caoai?thaaiue aeei?enoiaothoue e?ea?nuee? caniae
??cieo oa?iaeieia?/ieo a?oi ?ineeiiiai, i?ia?aeueiiai oa neioaoe/iiai
iioiaeaeaiiy. I?e oeueiio iniaeeaa i?noea caeiathoue i?e?iaei? i?ia?aee,
iaeieie c yeeo ? oeaie?oe. Eaoae?oe/i?, ?iiiiai?ii?, ni?aoe?ei?
aeanoeaino?, aeniea naeaeoeai?noue iiaeeiaiiy, caeaoi?noue ?iciiae?eyoe
ca ?ici??ii ?iie oa iieaeoee ??cieo ?a/iaei, oea aeaeaei ia iiaiee
ia?ae?e ?o iiceoeaieo aeanoeainoae. Aaaeeeaa cia/aiiy ia? ? aeiiii?/ia
noi?iia ieoaiiy. Oe?a?ia ia? oe?eee ?yae cia/ieo ?iaeiaeu oeaie?oiaeo
ii??ae. I?iaiiciaai? ?ano?ne a?aee?eoiai aeaeiaoaaiiy oeaie?o?a
Caea?iaonueei? iaeano? neeaaeathoue a?ey 1 ie?ae. oii. Oaeiae oe?
i?ia?aee ca oe?eei ?yaeii aeanoeainoae ia iinooiathoueny neioaoe/iei,
eio?? ae?iaeythoueny a aaaaoueio e?a?iao, a ca aa?o?noth ?o cia/ii
aeaoaao?. Aeoiaey/e c oeueiai, aeei?enoaiiy i?e?iaeieo oeaie?o?a a
i?aeoe/i?e iaaeeoeei? Oe?a?ie aeooaeueii ? ?ice?eaa? aaeee? ia?niaeoeae
noai?aiiy e?ea?nueeeo i?aia?ao?a ia ?o iniia?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa aeeiiaia o a?aeiia?aeiino? c ieaiii iaoeiai — aeine?aeieo ?ia?o
Oe?a?inueei? oa?iaoeaaoe/ii? aeaaeai?? ca i?iaeaiith “Oa?iaoe?y” (iiia?
aea?aeaaii? ?a?no?aoe?? 01.9.1.002383).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoith ?iaioe ? ?ic?iaea iaoeiai
iaa?oioiaaiiai neeaaeo, oaoiieia?? ? iaoiae?a aiae?co eiia?iiaaiiai
i?aia?aoo a oi?i? a?aioe ia iniia? i?e?iaeiiai oeaie?oo aeey e?eoaaiiy
ae?aceiaeo iioeiaeaeaiue oeoieo oa aeaaiaaeoeyoeiaei? eeoee.

?aae?caoe?y iinoaaeaii? iaoe ia?aaeaa/aea ae??oaiiy ne?aeoth/eo
caaaeaiue:

Aiae?c e?oa?aoo?ieo aeaieo c ieoaiue ao?ieia??, iaoiaaiaco oa oa?ai??
ae?aceiai? oai?iae OEO;

I?iaaaeaiiy eiiieaeno o?ceei — o?i?/ieo, oaoiieia?/ieo, i?e?ia?ieia?/ieo
? iaaeeei — a?ieia?/ieo aeine?aeaeaiue ii noai?aiith iioeiaeueiiai
neeaaeo eiia?iiaaiiai i?aia?aoo;

Oai?aoe/ia ? aenia?eiaioaeueia iaa?oiooaaiiy neeaaeo ? oaoiieia??
a?aioe, ui ?ic?iaeai?;

?ic?iaea iaoiae?a eiio?ieth yeino? ?ic?iaeaii? e?ea?nueei? oi?ie;

Aea/aiiy niaoeeo?/ii? aeoeaiino? ? a?ieia?/ii? iaoe?aeeeaino? a?aioe;

?ic?iaea ii?iaoeaii — oaoi?/ii? aeieoiaioaoe?? ia eiia?iiaaiee i?aia?ao
? iiaeaiiy ?? aei Oa?iaeieia?/iiai eii?oaoo I?i?noa?noaa ioi?iie
caei?ia’y Oe?a?ie.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. I?iaaaeaii ii??aiyeueiee
aiae?c aeayeeo aeanoeainoae i?e?iaeiiai oeaie?oo c neioaoe/ieie
oeaie?oaie oa i?e?iaeiei aaioii?oii, ye? aaea aeaaii aeei?enoothoueny a
oa?iaoeaaoe/i?e i?aeoeoe?.

Aia?oa aecia/aia i?ioeae?aceiaa aeoeai?noue i?e?iaeiiai oeaie?oo ia?ee
A.

Aia?oa iaoeiai iaa?oioiaaii neeaae oa oaoiieia?th a?aioe ia iniia?
i?e?iaeiiai oeaie?oo aeey e?eoaaiiy ae?aceiaeo iioeiaeaeaiue oeoieo oa
aeaaiaaeoeyoeiaei? eeoee.

Iieacaia a?ieia?/ia iaoe?aeeea?noue ? aeniea niaoeeo?/ia aeoeai?noue
?ic?iaeaiiai i?aia?aoo.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

?ic?iaeaia oa iiaeaia aei Oa?iaeieia?/iiai eii?oaoo I?i?noa?noaa ioi?iie
caei?ia’y Oe?a?ie ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia a?aioee
“A?aoeaiao” aeey io?eiaiiy aeicaieo ia i?iaaaeaiiy ee?i?/ieo
aei?iaoaaiue.

Ie?ai? o?aaiaioe ?iaioe ai?iaaaeaeai? a iaa/aeueiee i?ioean ?yaeo AOC?a
e?a?ie.

Iniaenoee aianie caeiaoaa/a:

I?iaaaeai? o?ceei-o?i?/i? oa oaoiieia?/i? aeine?aeaeaiiy oeaie?oo
i?e?iaeiiai ia?ee “A” a ii??aiyii? c neioaoe/ieie oeaie?oaie oa
i?e?iaeiei aaioii?oii;

Iaa?oioiaaii neeaae oa ?ic?iaeaia oaoiieia?y a?aioe ia iniia?
i?e?iaeiiai oeaie?oo;

I?iaaaeai? o?ceei-o?i?/i? ? oaoiieia?/i? aeine?aeaeaiiy a?aioe i?ae
oiiaiith iacaith “A?aoeaiao”;

?ic?iaeaia ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia i?aia?ao “A?aoeaiao”.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe?eii?
?iaioe aeiiia?aeaeenue ia: iaoeiai-i?aeoe/i?e eiioa?aioe?? “Iao/iua
aeinoeaeaiey e i?iaeaiu i?iecaiaenoaa eaea?noaaiiuo n?aaenoa” (
Oa?ueeia, 1995 a.); iaoeiai-i?aeoe/i?e eiioa?aioe?? “Aeinyaiaiiy
no/anii? oa?iaoe?? — a iaaee/io i?aeoeeo” ( Oa?e?a, 1996 ?.);
i?aeia?iaeii? eiioa?aioe??, i?enay/aii? 75-??//th c aeiy ia?iaeaeaiiy
?aeoi?a OO? i?ioani?a Naea Ae.I. “Oai??y ? i?aeoeea noai?aiiy
e?ea?nueeeo i?aia?ao?a” ( Oa?e?a, 1998 ?.).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 5 iaoeiaeo noaoae.

No?oeoo?a oa ianya ?iaioe. Aeena?oaoe?y aeeeaaeaia ia 129 noi??ieao
iaoeiiieniiai oaenoo, neeaaea?oueny ?c anooio, i’yoe ?icae?e?a,
aeniiae?a, nieneo aeei?enoaii? e?oa?aoo?e oa aeiaeaoe?a.

?iaioa ?ethno?iaaia 29 oaaeeoeyie oa 12 ?enoieaie. Nienie e?oa?aoo?e
i?noeoue 139 e?oa?aoo?ieo aeaea?ae, c yeeo 35 ?iicaiieo aaoi??a.

CI?NO ?IAIOE

1.Aea/aiiy o?ceei-o?i?/ieo oa oaoiieia?/ieo aeanoeainoae i?e?iaeiiai
oeaie?oo ia?ee “A”.

Ia?i?aeueia i?ecia/aiiy e?e?a ia iia(ycaii aeey ethaeeie c aieueiaeie
a?ae/oooyie. Iaea?eueo i?eeiyoeie c oe??? a?oie e?e?a ? ??aee?: ne?iie,
noniaic??, e?aie?, ?ic/eie; oaa?ae?-a?aioeueiaai? ii?ioee oa oaaeaoee.
I?e aiae?c? iaaeie?e?a oa aeinoi?inoa aeacaieo oi?i aoei anoaiiaeaii, ui
a?aioee aea?aeii a?ae??ciythoueny a?ae ?ioeo ?yaeii ia?aaaa: aiie
i?aeoe/ii ia i?noyoue aieiae, ui ni?ey? ca?eueoaiith no?ie?a
i?eaeaoiino?; ?ic/eiaiiy ?o o aiae? ia?aae i?eeiaiiyi aeeeth/a?
iaiao?aei?noue aaaaeaiiy noaa?e?caoi??a; a?aeiaaea? iaiao?aei?noue
eiiieaeoaoe?? aeicoth/eie i?enoinoaaiiyie, ai aeica iiaea ?aaoethaaoenue
/eneii iaeao?a ia i?eeii; caa??aa?oueny i?e?ia?ieia?/ia /enoioa
i?aia?aoo oiui.

A?aoiaoth/e oea, a oaeiae aeoiaey/e c iaaee/iiai oa oa?iaoeaaoe/iiai
canoinoaaiiy oeaie?o?a, iaea?eueo iioeiaeueiith e?ea?nueeith oi?iith ?
a?aioee.

Aeey ?ic?iaee iioeiaeueiiai neeaaeo a?aioe c oeaie?oii noaei
iaiao?aei?noth aea/aiiy eiai o?ceei-o?i?/ieo oa oaoiieia?/ieo
aeanoeainoae.

Ia?aae i?iaaaeaiiyi aeine?aeaeaiue oeaie?o i/euaee ca iaoiaeeeith i?io.
Ae.I.Naea, yea caniiaaia ia a?aeio/oaaii? a?oaeo /anoie oa i?neo
aeaeaiooaaiiyi oeaie?oiai? noniaic??. I?iaiaeeee aeae?eueea
a?aeio/oaaiue oiio, ui o?eueee i?ney o?ueioe?aoiiai a?aeio/oaaiiy
aeinyaa?oueny ca?eueiaiiy i?ia?aeo a?ae aeii?oie. I?ney oeueiai oeaie?o
aenoooaaee i?e 140-160(N, ae??aieee oa i?in?thaaee /a?ac neoi.

Aecia/aiiy oaieiaiai aoaeoo cii/oaaiiy.

Aeey aeine?aeaeaiiy aoee acyo? oeaie?o i?e?iaeiee, a aeey ii??aiyiiy,
i?e?iaeiee aaioii?o ? neioaoe/i? oeaie?oe NaX oa NaA. Aeey aecia/aiiy
oaieioe cii/oaaiiy aoee i?iaaaeai? oa?iio?i?/i? aeine?aeaeaiiy c?ace?a,
ui aeaei ciiao e?euee?nii ioe?ieoe i??o ?o a?ae?io?eueiino?. C oe??th
iaoith aeei?enoaee eiei?eiao? aae?aaaoiiai oeio. C?acee aaeooioaaee i?e
105(5(N ia i?ioyc? 5 aiaeei. Aenia?eiaioaeueii aecia/aee i?e??no
oaiia?aoo?e ca ia??iae cii/oaaiiy ? ?ic?aoiaoaaee aaee/eio oaieioe. I?e
oeueiio aoee iaea?aeai? ne?aeoth/? iieacieee oaieioe cii/oaaiiy: aeey
i?e?iaeiiai oeaie?oo — 12,83(0,1 eae/a, i?e?iaeiiai aaioii?oo —
17,82(0,2 eae/a, neioaoe/ieo oeaie?o?a NaO — 5,80(0,2 eae/a, NaA —
5,00(0,1 eae/a.

Ia iniia? io?eiaieo aeaieo aoei ?ic?aoiaaii cia/aiiy ieoiii? iiaa?oi?
oeaie?oo, yea neeaei 463,0(0,2 i(. Aiae?c iaea?aeaieo ?acoeueoao?a
na?ae/eoue, ui iaea?eueo aenieee oaieiaee aoaeo ia? aaioii?o, a
iaeiaioee — neioaoe/i? oeaie?oe. I?e?iaeiee oeaie?o ia? a?aeiinii
aenieee oaieiaee aoaeo cii/oaaiiy, ui iiynith?oueny eiai cia/iith
ieoiiith iiaa?oiath. Oaeei /eiii, ca ?acoeueoaoaie aeine?aeaeaiue iiaeia
c?iaeoe aeniiaie, ui i?e?iaeiee oeaie?o oa?aeoa?eco?oueny a?aeiinii
aenieith a?ae?io?euei?noth na?aae ?a/iaei i?ia?aeueiiai iioiaeaeaiiy.
Oea iiynith? aeia?o caeaoi?noue oeueiai i?ia?aea aei aaeni?aoe??.

Aecia/aiiy iaa?yeo i?e?iaeiiai oeaie?oo o aiae?.

Aeey aeine?aeaeaiiy oe??? oa?aeoa?enoeee aoea aea?aia iaoiaeeea
aecia/aiiy ca A.Aaneeue?aei, yea ia? oo ia?aaaao, ui aeicaiey? i?yiei
niinoa?aaeaiiyi aeyaeoe iaa?ye. ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue
iaaaaeai? a oaaeeoe? 1. Aeai? oaaeeoe? iieacothoue, ui i?ioyaii ia?oeo
30 naeoiae ?nioaaea cao?eiea iaa?yeo, yea iia(ycaia c ia??iaeii
?iciianthaeaeaiiy aiaee a oeaie?oiaeo eaiaeao. Nai i?ioean iaa?yeo
a?aeaoaaany 5-6 aiaeei, i?ney /iai oeaie?o i?aeoe/ii ia iaa?yeaa. Ia
i?aenoaa? ?acoeueoao?a aeine?aeaeaiue ?ic?aooaaee ia(?i ii? caiiaiaieo
aiaeith, yeee neeaa 0,1651(0,0002 ni3/a. Aeoiaey/e c oeueiai, iiaeia
c?iaeoe aeniiaie, ui oeaie?o iaa?yea? ca ?aooiie ?iciianthaeaeaiiy aiaee
a eaiaeao oa ii?iaeieiao i?ia?aea, a iaeneiaeueia aaee/eia eiai iaa?yeo
iacia/ia ? neeaaea? 7,18% a?ae ii/aoeiaiai ia(?io i?ia?aea.

Oaaeeoey 1- Iaa?ye oeaie?oo i?e?iaeiiai o aiae?

*an iaa?yeo Aaee/eia iaa?yeo,I,ni3/a

Naeoiaee: 5 0

10 0

15 0

20 0

30 0,098(0,002

45 0,134(0,002

Oaeeeie: 1 0,150(0,001

2 0,185(0,001

3 0,204(0,0015

4 0,222(0,002

5 0,238(0,001

6 0,247(0,0015

7 0,256(0,001

8 0,264(0,0015

9 0,272(0,002

10 0,277(0,0015

20 0,312(0,002

30 0,329(0,001

40 0,344(0,001

50 0,363(0,0015

Aiaeeie: 1 0,367(0,0015

2 0,400(0,001

3 0,425(0,002

4 0,437(0,0015

5 0,444(0,002

6 0,507(0,001

12 0,507(0,0025

24 0,514(0,002

Aecia/aiiy no?oeoo?ii — iaoai?/ieo ia?aiao??a oa ?aieia?/ieo
aeanoeainoae aiaeieo aeenia?n?e i?e?iaeiiai oeaie?oo.

No?oeoo?ii-iaoai?/i? ia?aiao?e aecia/aee ca aeiiiiiaith i?eeaaeo
Aaeea?a-?aa?iaea?a, ?aieia?/i? aeine?aeaeaiiy i?iaiaeeee ia ?ioaoe?eiiio
a?neiceiao??. Aeine?aeaeaiiy aeenia?n?e oeaie?oo i?iaiaeeee a ii??aiyii?
c i?e?iaeiei aaioii?oii. I?ia?aeuei? aeenia?n?? c eiioeaio?aoe??th a?ae
10 aei 65% aiooaaee iaoiaeii ?icaaaeaiiy.

Aiae?c ?acoeueoao?a aeine?aeaeaiue iieacaa, ui oi?ioaaiiy no?oeoo?e a
nenoaiao caeaaeeoue a?ae ai?noo aeenia?nii? oace. C? ca?eueoaiiyi
eiioeaio?aoe?? oaa?aei? oace i?ioean no?oeoo?iooai?aiiy iineeth?oueny,
ui i?aeoaa?aeaeo?oueny c?inoaiiyi i?oei?nieo oa a(yce?nieo iieaciee?a.
Iaeiae a aeine?aeaeaieo nenoaiao oeaie?o-aiaea oa aaioii?o-aiaea
?ioaineai?noue i?io?eaiiy no?oeoo?iooai?aiiy iaiaeiaeiaa. Aiaei?
aeenia?n?? aaioii?oo i?e eiioeaio?aoe?? aeenia?nii? oace 15%
ooai?ththoue aa?aaaoeaii no?ee? eiaaoeyoe?ei? no?oeoo?e. Aeenia?n??
oeaie?oo ooai?ththoue no?ee? no?oeoo?e i?e eiioeaio?aoe?? oaa?aei? oace
40% oa aeua, ui iia(ycaii c iniaeeainoyie e?enoae?/ii? aoaeiae i?ia?ae?a
oa i?e?iaeith ?o iai?iieo eao?ii?a. Oaeei /eiii, iaea?aeai? ?acoeueoaoe
aeine?aeaeaiue na?ae/aoue, ui aiaei? aeenia?n?? oeaie?oo iathoue aaeeeo
aa?aaaoeaio no?ee?noue. Oea aeaco? ia i?eaeaoi?noue oeaie?oo aeey
i?eaiooaaiiy noniaic?e.

Oaoiieia?/i? aeine?aeaeaiiy i?e?iaeiiai oeaie?oo.

Aeey aea/aiiy oaoiieia?/ieo aeanoeainoae oeaie?oo aecia/aee ne?aeoth/?
oaoiieia?/i? oa?aeoa?enoeee: o?aeoe?eiee neeaae, neio/?noue, ianeiio
aonoeio oa eoo i?e?iaeiiai oeino. Ia i?aenoaa? iaea?aeaieo aeaieo iiaeia
c?iaeoe aeniiaie, ui a o?aeoe?eiiio neeaae? ii?ioeo oeaie?oo
ia?aaaaeathoue o?aeoe?? c ?ici??ii /anoie ia a?eueoa 0,125 ii, a oaeiae,
ui oeaie?o aieiae?? iiaaiith neio/?noth.

?acoeueoaoe aeuaaeacaieo eiiieaenieo o?ceei-o?i?/ieo oa oaoiieia?/ieo
aeine?aeaeaiue i?e?iaeiiai oeaie?oo ia?ee “A” aoee a?aoiaai? i?e
?ic?iaoe? iioeiaeueiiai neeaaeo i?aia?aoo oa aenia?eiaioaeueiiio
iaa?oiooaaii? aeai?o e?ea?nueei? oi?ie.

2. ?ic?iaea neeaaeo oa oaoiieia?? a?aioe ia iniia? i?e?iaeiiai oeaie?oo.

Iaeia c aieiaieo caaaeaiue oaoiieia?? iaea?aeaiiy aenieiye?nieo e?e?a
iieyaa? a iiooeo oa aeai?? oaeeo aeiiii?aeieo ?a/iaei, ye? ii?yae c
iaaeaiiyi e?eai iaiao?aeieo oaoiieia?/ieo aeanoeainoae ?iaeee a nooo?aee
aieea ia aeoeai?noue ae?th/iai i?aia?aoo.

Aeoiaey/e c oeueiai, a oaeiae a?aoiaoth/e o?ceei-o?i?/i? oa
oa?iaeieia?/i? aeanoeaino? oeaie?oo, iaie aea?ai? a yeino? aeiiii?aeieo
?a/iaei iaeoei yaeo/iee oa e?ioiaeue ea?oiieyiee, yeee oe?iei
aeei?enoiaothoue a oaoiieia?? aeaioiaeaiiy oaa?aeeo e?ea?nueeeo oi?i.
Aeaioiaeee ?yae c?ace?a a?aioe ia iniia? i?e?iaeiiai oeaie?oo c ??ciei
ai?noii iaeoeio oa e?ioiaeth (5,10,15,20,25,30,35%). E?eoa??yie ioe?iee
iaea?aeaieo a?aioe aoee ciai?oi?e aeaeyae, i?oei?noue ia noe?aii?noue oa
?iciaaea?i?noue. A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue aoei aea?aii 2
neeaaee a?aioe: ia?oee neeaae i?noeoue 70% oeaie?oo oa 30% iaeoeio,
ae?oaee neeaae — 70% oeaie?oo oa 30% e?ioiaeth. A iiaeaeueoiio ?acii c
eaoaae?ith ee?i?/ii? oa?iaoe?? aea/aeanue i?ioeae?aceiaa aeoeai?noue
oeeo aeaio neeaae?a (Oaaeeoey 2).

Oaaeeoey 2- Aieea oeaie?oo oa a?aioe ia eiai iniia? ia ia?aa?a
ae?aceiaiai iioeiaeaeaiiy o uo??a

Oiiae aeine?aeo *enei oaa?ei c ae?aceaie Ae?aceiaee ?iaeaen

Eiio?ieue 100 32,33(0,02

Oeaie?o 50 6,92(0,02

A?aioee:neeaae 1 48 6,04(0,03

A?aioee:neeaae 2 52 6.98(0,02

Aeai? oaaeeoe? na?ae/aoue, ui i?e aaaaeaii? iaeoeio yaeo/iiai
aeoeai?noue oeaie?oo iacia/ii c?inea, a i?e aaaaeaii? e?ioiaeth
ea?oiieyiiai — iaaiaee ciaioeeanue.

Oaeei /eiii, iaea?eueo iioeiaeueiei aoei ia?aii c?acie, yeee a nai?io
neeaae? ia? 70% i?e?iaeiiai oeaie?oo ia?ee “A” oa 30% iaeoeio yaeo/iiai.

Iaeiae, aiae?coth/e aeai?, ia iiaeia eacaoe, ui iaea?aeai? a?aioee
i?iyaeythoue aenieo i?ioeae?aceiao aeoeai?noue. *a?ac oea, aeey
iineeaiiy i?ioeae?aceiai? ae?? i?aia?aoo oa a?aoiaoth/e o?ceei-o?i?/i?
oa oa?iaeieia?/i? aeanoeaino?, aeiaeaee aei neeaaeo a?aioe iaoeeo?aoeee.

Aeey oeueiai aeaioiaeee ?yae c?ace?a c ??ciith eiioeaio?aoe??th
iaoeeo?aoeeeo (0,1; 0,5; 1,0; 1,5; 2,0; 5,0%). ? aea/aee niaoeeo?/io
aeoeai?noue aeaioiaeaieo c?ace?a (Oaaeeoey 3).

Oaaeeoey 3-Aea/aiiy i?ioeae?aceiai? aeoeaiino? a?aioe ia iniia? oeaie?oo
c ??ciei ai?noii

iaoeeo?aoeeeo

Oiiae aeine?aeo Ai?no iaoeeo?aoeeeo,% *enei oaa?ei c ae?aceaie
Ae?aceiaee ?iaeaen

Eiio?ieue — 100 32,33(0,02

Oeaie?o — 50 6,92(0,02

Neeaae 1 0,1 50 6,89(0,04

Neeaae 2 0,5 48 5,12(0,03

Neeaae 3 1,0 43 1,85(0,01

Neeaae 4 1,5 45 3,24(0,02

Neeaae 5 2,0 45 3,86(0,02

Neeaae 6 5,0 46 4,34(0,02

C aeaieo oaaeeoe? aeaeii, ui iaea?eueoo i?ioeae?aceiao aeoeai?noue
iathoue a?aioee neeaaeo 3, ye? ni?eythoue cieaeaiith ae?aceiaiai
?iaeaeno a 17,5 ?ac?a a ii??aiyii? c eiio?ieueiei cia/aiiyi.

I?ioeae?aceiaa aeoeai?noue oeeo a?aioe a 4 ?ace ia?aaeuo? aeoeai?noue
i?e?iaeiiai oeaie?oo, ui na?ae/eoue i?i ?aoe?iiaeuei?noue aaaaeaiiy aei
neeaaeo a?aioe iaeoeio yaeo/iiai oa iaoeeo?aoeeeo.

Aeoiaey/e c iaea?aeaieo aeaieo, iaie i?iiiio?oueny ne?aeoth/ee neeaae
a?aioe i?ae oiiaiith iacaith “A?aoeaiao”:

Ia 100 a — oeaie?oo i?e?iaeiiai -69,0 a

iaoeeo?aoeeeo — 1,0 a

iaeoeio yaeo/iiai -30,0 a

I?e aecia/aii? iioeiaeueii? e?eueeino? caieiaeoaa/a, ui aaiaeeoueny aei
iane aeey iaea?aeaiiy a?aioe, i?iaiaeeee aecia/aiiy o?aeoe?eiiai
neeaaeo. Aei noi?o? e?ea?nueeeo e aeiiii?aeieo ?a/iaei iine?aeiaii
aaiaeeee 12, 14, 16, 18, 20, 22, 24, 26, 28 oa 30% aiaee. Caieiaeaio
iano i?ioe?aee e??cue neoi c ae?aiao?ii ioai??a 2,0 ii ? aenoooaaee aei
caeeoeiai? aieiaino? 2-3%. Nooo iano aoi?eiii a?aioethaaee i?ioe?aiiyi
e??cue neoi c ae?aiao?ii ioai??a 2,0 ii ? aecia/aee o?aeoe?eiee neeaae.
?acoeueoaoe aeine?aeaeaiue iieacaee, ui i?e eiioeaio?aoe?? caieiaeoaa/a
iaioa 18% i?aeoe/ii a?aenooiy a?aioeueiaaia no?oeoo?a, a i?e
eiioeaio?aoe?? 28 ? 30% ii/eia?oueny caeeiaiiy ioai??a a?aioeyoi?a.
*?oei ae?aaeaia a?aioeueiaaia no?oeoo?a i?iyaey?oueny i?e aaaaeaii?
24-26% aiaee. Aea/aiiy oaoiieia?/ieo aeanoeainoae iaea?aeaieo a?aioe
aeicaieeei aeyaeoe o?aeoe?eiee iioeioi, yeee ooai?th?oueny i?e aaaaeaii?
o a?aioeueiaaio iano 26% aiaee.

A?aioee aiooaaee iaoiaeii aieiaiai a?aioethaaiiy, a yeino? caieiaeoaa/a
aeei?enoaee aiaeo i/euaio. I?ney a?aioethaaiiy a?aioee aenoooaaee.

Oaoiieia?/ia noaia ae?iaieoeoaa a?aioe “A?aoeaiao” iaaaaeaia ia ?en.1.

Aei neeaaeo a?aioe aoiaeyoue ?a/iaeie i?ia?aeueiiai, ?ineeiiiai oa
neioaoe/iiai iioiaeaeaiiy, eiaeia c yeeo ia? oa?aeoa?io oa?i?/io
iiaaae?ieo. Aeoiaey/e c oeueiai, aecia/aiiy oaiia?aoo?e aenoooaaiiy
i?aia?aoo i?iaiaeeee, ca aeiiiiiaith aeaieo oa?iia?aa?iao?e/iiai
aiae?co. Oeueiio aiae?co i?aeaeaaaee ne?aeoth/? c?acee: iaoeeo?aoeee,
iaeoei yaeo/iee oa ?ic?iaeai? a?aioee. Oeaie?o i?e?iaeiee aiae?co ia
i?aeaeaaaee oiio, ui ca aaaaoi/enaeueieie aeaieie e?oa?aoo?e oaiia?aoo?a
aeoeaaoe?? oeaie?oo neeaaea? 400(N, a ?iceeaaeaiiy ii/eia?oueny i?e
800(N.

Iaea?aeai? aea??aaoia?aie iieacaee, ui iaoeeo?aoeee aei 230(N ia
ia?aoa?ieth? ci?i, o iaeoeia yaeo/iiai ao?a/aiiy iane ii/eia?oueny i?ney
50(N. Io?eiaia aea??aaoia?aia ?ic?iaeaiiai i?aia?aoo na?ae/eoue, ui
a?aioee ii/eiathoue ao?a/aoe iano i?ney 60(N (?en.2).

Oa?i?i aenoooaaiiy a?aioe ?ic?aoiaoaaee oai?aoe/ii ca aeiiiiiaith
ae?aa?aie aieiaiai iia?o?y ?aic?ia.

Oaeei /eiii, ia i?aenoaa? iaea?aeaieo aeaieo anoaiiaeee ?aaeei
aenoooaaiiy ?ic?iaeaieo a?aioe: i?e oaiia?aoo?? 50(5(N i?ioyaii 1
aiaeeie a eaei?eoa?i?e nooa?oe? aac i?eioniaiai a?aeae?eaiiy aieiaiai
iia?o?y.

C iaoith noaiaea?oecaoe?? i?aia?aoo, a oaeiae aeey aea/aiiy
noaa?eueiino? a?aioe a i?ioean? caa??aaiiy, iaie ?ic?iaeai? iaoiaee
ye?niiai oa e?euee?niiai aiae?co.

Aiae?c iaoeeo?aoeeeo i?iaiaeeee iaoiaeii OO-niaeo?ineii??. Aeey oeaie?oo
i?e?iaeiiai canoiniaoaaee iaoiae aecia/aiiy eiai iai?iii? ?ieino?,
aeei?enoiaoth/e iaoiaeeeo OO-21 O?N? 485-90.

Noaa?euei?noue i?aia?aoo aea/aeanue a oiaeiaoe? c iie?ia?ieo
oa?iicaa?thaaeueieo iaoa??ae?a i?ioyaii 2 ?ie?a a cae/aeieo oiiaao
(20(2(N). *a?ac eiaei? 6 i?nyoe?a a?aioee i?aeaeaaaee anaa?/iiio
o?ceei-o?i?/iiio oa i?e?ia?ieia?/iiio aeine?aeaeaiith.
Aeine?aeaeoaaeenue: ciai?oi?e aeaeyae, ai?no aieiae, /an ?iciaaeo,
?aaeoe?? ?aeaioeo?eaoe??, e?euee?niee ai?no ae?th/eo ?a/iaei,
i?e?ia?ieia?/ia /enoioa, oaeiae aecia/aeanue i?ioeae?aceiaa aeoeai?noue
a?aioe.

Aiae?c ?acoeueoao?a aeine?aeaeaiue iieacaa, ui oiaeiaea ia aieeaa? ia
ye?noue i?aia?aoa ? a?aioee “A?aoeaiao” caeeoathoueny noaa?eueieie ia
i?ioyc? 2 ?ie?a.

3. Aea/aiiy oa?iaeieia?/ii? aeoeaiino? oeaie?oo i?e?iaeiiai ia?ee “A” oa
a?aioe “A?aoeaiao”.

Niaoeeo?/ia aeoeai?noue oeaie?oo oa a?aioe “A?aoeaiao” aoea aea/aia ia
eaoaae?? ee?i?/ii? oa?iaoe?? i?ae ea??aieoeoaii ae.i.i., i?ioani?a
?.A.Coiaiaoeue ia iiaeae? aeeiaieueii-i?aaei?cieiiiai? aeano?oeoe??
oeoieo. Oey iiaeaeue aoea aea?aia c o?aooaaiiyi ?? aenieiai
a?aeoai?aiiy, iaaeiaai/aniino? ieeio, a?aeiia?aeiino? iaoai?cio ?icaeoeo
iaoieia?? iaeiiai c iaoiaaiaoe/ieo iaoai?ci?a ?icaeoeo ae?acee o
ethaeeie.

Aeine?aeaeaiiy oeaie?oo i?iaiaeeee a ii??aiyii? c aenieiaoaeoeaiei
caniaii “Oeeiaoeaeei”. E?eoa??yie ioe?iee aoee i?e?ineii?/iee iaeyae,
iaoiii?oieia?/ia aea/aiiy neeciai? iaieiiee oeoieo o a?eeo uo??a,
e?euee?noue oaa?ei c ae?aceaie, ieiua ae?acie o an?o oaa?ei ? ae?aceiaee
?iaeaen (Oaaeeoey 4).

Oaaeeoey 4- I?ioeae?aceiaa aeoeai?noue oeaie?oo i?e?iaeiiai oa
“Oeeiaoeaeeio” ia iiaeae? aeeiaieueii-i?aaei?cieiiiaeo ae?acie

Oiiae aeine?aeo E?euee?noue oaa?ei c ae?aceaie Ieiua ae?acie o oaa?ei
Ae?aceiaee ?iaeaen

Iaoieia?y 100 32,33(0.02 32,33

Oeaie?o 51 11,57(4,11 6,92

“Oeeiaoeaeei” 78 13,70(5,10 10,60

*?(0,05 o a?aeiioaii? aei oaa?ei, yeeo ia e?eoaaee

I?e aeine?aeaeaii? a?aioe “A?aoeaiao” i?aia?aoii ii??aiyiiy aea?aee
iae?ieoiao ie?th, ye aenieiaoaeoeaiee ?aia?aoeaiee can?a, a oaeiae
iaoeeo?aoeee. Io?eiai? ?acoeueoaoe iaaaaeai? a oaaeeoe? 5.

Ii??aiyeueia aea/aiiy i?ioeae?aceiaeo aeanoeainoae iieacaei, ui oeaie?o
i?e?iaeiee ia?ee “A” cieaeo? aei 51% e?euee?noue oaa?ei c ae?aceaie,
ciaioo? ieiuo ae?acie aei 11,57 aae?a, cieaeo? ae?aceiaee ?iaeaen aei
6,92 ? ia? iaea?eueo aenieo i?ioeae?aceiao aeoeai?noue a ii??aiyii? c
i?aia?aoii “Oeeiaoeaeei”.

Oaaeeoey 5 — Aieea a?aioe “A?aoeaiao” ia ia?aa?a aenia?eiaioaeueiiai
ae?aceiaiai o?aaeaiiy oeoieo

o uo??a

Oiiae aeine?aeo E?euee?noue oaa?ei c

ae?aceaie Ieiua

ae?acie o oaa?ei Ae?aceiaee ?iaeaen

Iaoieia?y 100 32,33(0,02 32,33

“A?aoeaiao” 43 4,29(3,23 1,85

Iae?ieoiaa ie?y 42 9,48(2,12 3,79

Iaoeeo?aoeee 65 8,12(2.07 8,62

*?(0,05 o a?aeiioaii? aei oaa?ei, yeeo ia e?eoaaee

A?aioee “A?aoeaiao” cieaeothoue aei 43% e?euee?noue oaa?ei c ae?aceaie,
ciaioothoue ieiuo ae?acie aei 4,29 aae?a, cieaeothoue ae?aceiaee ?iaeaen
aei 1,85, ui a ii??aiyii? c iaoieia??th neeaaea? 17,5 ?ac?a. Oaeiae
a?aioee “A?aoeaiao” ca i?ioeae?aceiaith aeoeai?noth ia?aaeuothoue a 2
?ace iae?ieoiao ie?th oa a 4,5 ?ace iaoeeo?aoeee.

Aea/aiiy aieeao i?aia?aoo ia nae?aoi?io ooieoe?th oeoieo i?iaiaeeee ca
iaoiaeii A.?.Aiae???ai? oa ?.I.Oa?iai?. Caaaeueio eeneioi?noue oa ai?no
oei?enoiaiaeiaai? eeneioe aecia/aee oeo?oaaiiyi ca Ieoaae?nii.
?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue iaaaaeai? a oaaeeoe? 6.

Oaaeeoey 6 — Aieea a?aioe “A?aoeaiao” ia nae?aoe?th oeoieiaiai nieo
o uo??a

Oiiae

Aeine?aeo Ia(?i

oeoieiaiai nieo, ie Caaaeueia

eeneioi?noue, iiieue/e A?eueia

eeneioi?noue, iiieue/e

Eiio?ieue (aiaea) 3,86(0,4 79,6(5,2 30,6(3,2

“A?aoeaiao” 5,12(0,8 85,4(2,4 31,5(2,8

Aeai? oaaeeoe? na?ae/aoue, ui i?e aaaaeaii? oaa?eiai a?aioe “A?aoeaiao”
ca?eueoeeenue ia(?i oa caaaeueia eeneioi?noue oeoieiaiai nieo, a
iniiaiiio, ca ?aooiie ca?eueoaiiy ca(ycaii? eeneioe. Aeoiaey/e c
oeueiai, iiaeia c?iaeoe aeniiaie, ui i?aia?ao “A?aoeaiao” ?iaeoue
caoeniee aoaeo i?e ae?aceia?e oai?ia?, cieaeoth/e oaeee aa?aneaiee
oaeoi? oeoieiaiai nieo, yeei ? a?eueia oei?enoiaiaeiaaa eeneioa.

?acoeueoaoe oa?iaeieia?/ieo aeine?aeaeaiue na?ae/aoue i?i aenieo
i?ioeae?aceiao aeoeai?noue a?aioe “A?aoeaiao” i?e e?eoaaii? ae?aceiaeo
ii?acie oeoieo oa aeaaiaaeoeyoeiaei? eeoee.

I?e aea/aii? aino?i? oa o?ii?/ii? oiene/iino? ia anoaiiaeaii iaaaoeaiiai
aieeao i?aia?aoa ia caaaeueiee noai oaa?ei, iieacieee e?ia? oa noai
aioo??oi?o i?aai?a. Ia i?aenoaa? oeueiai c?iaeaii aeniiaie, ui i?aia?ao
ia oe?aeeeaee ? ia oiene/iee i?e aioo??oiueiio canoinoaaii?.

??aaiue i?e?iaii? eiioai?iaoe?? i?aia?aoo aecia/aee ca iaoiaeeeith AeO
O1, aei. 2, n.193. Ca ?acoeueoaoaie aeine?aeaeaiue anoaiiaeaii, ui
a?aioee “A?aoeaiao” caaeia?eueiythoue aeiiaai AeO O? aeae. c i?e?iaii?
/enoioe.

AENIIAEE

Ia i?aenoaa? e?oa?aoo?ieo aeaieo iieacaia aeooaeuei?noue i?iaeaie
ae?aceiai? oai?iae oa aeioe?euei?noue canoinoaaiiy i?e?iaeieo oeaie?o?a
a iaaeeoeei? oa oa?iaoe??.

2.Aea/aii ?yae o?ceei — o?i?/ieo aeanoeainoae i?e?iaeiiai oeaie?oo ia?ee
“A” — oaieioa cii/oaaiiy,e?iaoeea iaa?yeo, no?oeoo?ii — iaoai?/i? oa
?aieia?/i? ia?aiao?e. Anoaiiaeaii, ui a?i oa?aeoa?eco?oueny a?aeiinii
aenieith a?ae?io?euei?noth na?aae ?a/iaei i?ia?aeueiiai iioiaeaeaiiy,
ia? iacia/iee iaa?ye o aiae? (7,18%) oa ia? caeaoi?noue ooai?thaaoe
eiaaoeyoe?eii-oeenio?iii? no?oeoo?e i?e 40-60% ai?noo oaa?aei? oace.

?acoeueoaoe oeeo aeine?aeaeaiue aoee a?aoiaai? i?e aeai?? aeiiii?aeieo
?a/iaei, a oaeiae e?ea?nueei? oi?ie i?aia?aoo.

Aea/ai? oaoiieia?/i? aeanoeaino? i?e?iaeiiai oeaie?oo ia?ee “A” —
o?aeoe?eiee neeaae, neio/?noue, eoo i?e?iaeiiai oeino, ianeiia aonoeia.
Anoaiiaeaii, ui oeaie?o aieiae?? iaaeinoaoiueith neio/?noth.

?ic?iaeaii neeaae oa oaoiieia?th ae?iaieoeoaa a?aioe ia iniia? oeaie?oo
i?ae oiiaiith iacaith “A?aoeaiao”.

5.?ic?iaeai? iaoiaeeee ye?niiai oa e?euee?niiai aiae?co ae?th/eo
?a/iaei, aea/ai? oaoiieia?/i? aeanoeaino? a?aioe.

Aea/aia noaa?euei?noue i?aia?aoa ia i?ioyc? 2 ?ie?a. Anoaiiaeaii, ui
i?ney o?eaaeiai caa??aaiiy i?aia?ao a?aeiia?aea? aeiiaai
ii?iaoeaii-oaoi?/ii? aeieoiaioaoe??.

Aecia/aia i?ioeae?aceiaa aeoeai?noue oeaie?oo i?e?iaeiiai oa a?aioe ia
eiai iniia?. Anoaiiaeaii, ui i?ae aieeaii oeaie?oo ae?aceiaee ?iaeaen
cieaeo?oueny a 4 ?ace, a i?ae aieeaii a?aioe “A?aoeaiao”- a 17,5 ?ac?a.

Aea/aia oiene/i?noue ?ic?iaeaiiai i?aia?aoo i?e iaeii?aciaiio aaaaeaii?
oa noao?ii?/ieo aeine?aeao. Anoaiiaeaii, ui a?i ia oiene/iee.

Aea/aia i?e?ia?ieia?/ia /enoioa iaea?aeaieo a?aioe, ye? a?aeiia?aeathoue
aeiiaai AeO O? aeae. c i?e?iaii? /enoioe.

?ic?iaeaia oa iiaeaia aei Oa?iaeieia?/iiai eii?oaoo IIC Oe?a?ie
ii?iaoeaii-oaoi?/ia aeieoiaioaoe?y ia a?aioee “A?aoeaiao” c iaoith
iaea?aeaiiy aeicaieo ia i?iaaaeaiiy ee?i?/ieo aei?iaoaaiue.

O?aaiaioe ?iaioe ai?iaaaeaeai? a o/aiaee i?ioean ?yaeo aoc?a e?a?ie.

Ca oaiith aeena?oaoe?? iioae?eiaai? ne?aeoth/? ?iaioe:

Oeaie?oe, ?o eeaneo?eaoe?y, o?ceei-o?i?/i? oa iaaeeei-a?ieia?/i?
aeanoeaino?. Iia?aeiieaiiy ? 1 (Ae.A.?eaa/oe, I.TH.Eii?i, A.?.*o?oia,
A.TH.O?ao?iiee, O.A.E?oonueeeo (( A?niee oa?iaoe??.-1995.-?
3-4.-C.80-85.

Oeaie?oe, ?o eeaneo?eaoe?y, o?ceei-o?i?/i? oa iaaeeei-a?ieia?/i?
aeanoeaino?. Iia?aeiieaiiy ? 2. Iaaeeei-a?ieia?/i? aeanoeaino? oeaie?o?a
( Ae.A.?eaa/oe, I.TH.Eii?i, A.?.*o?oia, A.TH.O?ao?iiee, O.A.E?oonueeeo
// A?niee oa?iaoe??.-1996.-? 1-2.-C.82-86.

Eieeieaeii-oeie/aneia eco/aiea i?e?iaeiiai ieia?aea oeaieeoa
(Ae.A.?eaa/oe, A.E.*oaoia, O.A.E?ooneeo, A.I.Eieaniee, N.A.Nie?eaeiiia
(( Oa?iaeii.-1996.-? 7.-C.30-32.

?ac?aaioea ninoaaa e oaoiieiaee a?aioe ia iniiaa i?e?iaeiiai oeaieeoa /
O.A.E?ooneeo, A.E.*oaoia, E.A.Coiaiaoe, Ae.A.?uaa/oe //
I?iaeci?.-1999.-? 5.-N.22-23.

Ii?aaeaeaiea niaoeeoe/aneie aeoeaiinoe Caea?iaoneiai i?e?iaeiiai
oeaieeoa / O.A.E?ooneeo, E.A.Coiaiaoe, A.E.*oaoia, Ae.A.?uaa/oe //
I?iaeci?.-1999.-? 7.-N.44.

E?oonueeeo O.A. “?ic?iaea neeaaeo oa oaoiieia?? i?ioeae?aceiaiai
i?aia?aoo o aeaeyae? a?aioe ia iniia? i?e?iaeiiai oeaie?oo”.
Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa oa?iaoeaaoe/ieo
iaoe ca niaoe?aeuei?noth 15.00.01- oaoiieia?y e?e?a oa i?iieneiaa
oa?iaoe?y; Oe?a?inueea oa?iaoeaaoe/ia aeaaeai?y, Oa?e?a, 1999 ?.

Aeena?oaoe??th ? ?oeiien.

A aeena?oaoe?? ?ic?iaeai? iaoeiai iaa?oioiaaiee neeaae, oaoiieia?y oa
iaoiaee aiae?co eiiiiiaio?a eiia?iiaaiiai i?aia?aoo i?ioeae?aceiai?
ae??. Aea/ai? iaoe?aeeea?noue, niaoeeo?/ia aeoeai?noue ?ic?iaeaiiai
i?aia?aoo; a oaeiae eiai noaa?euei?noue i?ae /an caa??aaiiy.

Eeth/ia? neiaa: oeaie?o, neeaae, ae?aceiaee ?iaeaen, oaoiieia?y,
noaa?euei?noue.

E?ooneeo O.A. “?ac?aaioea ninoaaa e oaoiieiaee i?ioeaiycaaiiiai
i?aia?aoa a aeaea a?aioe ia iniiaa i?e?iaeiiai oeaieeoa”. Aeenna?oaoeey
ia nieneaiea o/aiie noaiaie eaiaeeaeaoa oa?iaoeaaoe/aneeo iaoe ii
niaoeeaeueiinoe 15.00.01- oaoiieiaey eaea?noa e i?iiuoeaiiay oa?iaoeey;
Oe?aeineay oa?iaoeaaoe/aneay aeaaeaiey, Oa?ueeia, 1999 a.

Aeenna?oaoeeae yaeyaony ?oeiienue.

Aeey ?ac?aaioee iioeiaeueiiai ninoaaa a?aioe ia iniiaa oeaieeoa eco/aiu
aai oeceei-oeie/aneea e oaoiieiae/aneea naienoaa.

Ii?aaeaeaiea oaieiaiai yooaeoa nia/eaaiey oeaieeoa aiaeie i?iaiaeeee i?e
iiiiue eaei?eiao?a aaeeaaaoiiai oeia. Yenia?eiaioaeueii ii?aaeaeyee
i?e?ino oaiia?aoo?u ca ia?eiae nia/eaaiey e ?ann/eouaaee aaee/eio
oaieiou. Aeey n?aaiaiey eniieueciaaee i?e?iaeiue aaioiieo e
neioaoe/aneea oeaieeou NaA e NaX. Ii ?acoeueoaoai enneaaeiaaiee
onoaiiaeee, /oi oeaieeo oa?aeoa?ecoaony ioiineoaeueii aunieie
aeae?ioeeueiinoueth n?aaee aauanoa ieia?aeueiiai i?ienoiaeaeaiey.
Eco/aiea iaaooaiey i?e?iaeiiai oeaieeoa a aiaea i?iaiaeeee ii iaoiaeeea
A. Aaneeueaaa. ?acoeueoaou i?iaaaeaiiuo enneaaeiaaiee iieacaee, /oi
i?ioeann iaaooaiey oeaieeoa i?iaeieaeaaony 5-6 /ania, iinea /aai ieia?ae
i?aeoe/anee ia iaaooaao, i?e/ai iaeneiaeueiay aaee/eia aai iaaooaiey
iacia/eoaeueiay e ninoaaeyao 7,18% io ia?aiia/aeueiiai iauaia.
No?oeoo?ii-iaoaie/aneea ia?aiao?u e ?aieiae/aneea naienoaa aiaeiuo
aeenia?nee i?e?iaeiiai oeaieeoa ii?aaeaeyee n iiiiuueth i?eai?a
Aaeea?a-?aaeiaea?a e ?ioaoeeiiiiai aeneiceiao?a. Enneaaeiaaiey
i?iaiaeeee a n?aaiaiee n i?e?iaeiui aaioiieoii. Aiaeec ?acoeueoaoia
enneaaeiaaiee iieacae, /oi noieeea eiaaoeyoeeiiiua no?oeoo?u ia?acotho
aiaeiua aeenia?nee aaioiieoa i?e eiioeaio?aoeee aeenia?iie oacu 15%, a
aeenia?nee oeaieeoa – i?e 40%, /oi naycaii n iniaaiiinoyie
e?enoaeee/aneiai no?iaiey ieia?aeia e i?e?iaeie eo iaiaiiuo eaoeiiia.
Aeey eco/aiey oaoiieiae/aneeo naienoa oeaieeoa ii?aaeaeyee o?aeoeeiiiue
ninoaa, nuio/anoue, ianuiioth ieioiinoue e oaie anoanoaaiiiai ioeina. A
?acoeueoaoa eco/aiey onoaiiaeee, /oi oeaieeo eiaao ieiooth nuio/anoue, a
?acia? /anoeoe ieia?aea ia i?aauoaao 0,125 ii.

I?e ?ac?aaioea ninoaaa e oaoiieiaee a?aioe ecaioiaeee ?yae ia?acoeia ia
iniiaa oeaieeoa n ?aciui niaea?aeaieai iaeoeia yaei/iiai e e?aoiaea
ea?oioaeueiiai. Ii ?acoeueoaoai eco/aiey i?ioeaiycaaiiie aeoeaiinoe
a?aioe onoaiiaeee, /oi i?e aaaaeaiee iaeoeia aeoeaiinoue oeaieeoa
aic?inea, a i?e aaaaeaiee e?aoiaea – iaiai?io oiaiueoeeanue. Oaeei
ia?acii, a ea/anoaa aniiiiaaoaeueiiai aauanoaa aue aua?ai iaeoei
yaei/iue. Aeey ii?aaeaeaiey eiioeaio?aoeee iaoeeo?aoeeea oaeaea
eco/aeanue i?ioeaiycaaiiay aeoeaiinoue ia?acoeia. Niaoeeoe/aneay
aeoeaiinoue i?e?iaeiiai oeaieeoa e a?aioe ia aai iniiaa ii?aaeaeyeanue
ia eaoaae?a eeeie/aneie oa?iaoeee iiae ?oeiaiaenoaii ae.i.i., i?ioanni?a
Coiaiaoe E.A. Aeey n?aaiaiey auee eniieueciaaiu oaeea aunieiyooaeoeaiua
i?aia?aou eae “Oeeiaoeaeei”, iaeaieoiaia ianei e iaoeeo?aoeee. Ia
iniiaaiee i?iaaaeaiiuo enneaaeiaaiee iaie i?aaeeiaeai ninoaa a?aioe ia
iniiaa i?e?iaeiiai oeaieeoa, iaeaaeathuee i?ioeaiycaaiiie aeoeaiinoueth.

I?aia?ao aioiaeee iaoiaeii aeaaeiiai a?aioee?iaaiey, a ea/anoaa
oaeaaeieoaey eniieueciaaee aiaeo i/euaiioth. Aeaaeiua a?aioeu nooeee a
eaei?eoa?iie nooeeea aac i?eioaeeoaeueiiai oaeaeaiey aicaeooa.
Ii?aaeaeaiea oaiia?aoo?u nooee i?aia?aoa i?iaiaeeee n iiiiuueth aeaiiuo
oa?iia?aaeiao?e/aneiai aiaeeca, a?aiy nooee ?ann/eouaaee oai?aoe/anee ii
aeeaa?aiia aeaaeiiai aicaeooa ?aiceia. Ia iniiaaiee iieo/aiiuo aeaiiuo
onoaiiaeee ?aaeei nooee ?ac?aaioaiiuo a?aioe: i?e oaiia?aoo?a 50+ 5iN ia
i?ioyaeaiee 1 /ana.

N oeaeueth noaiaea?oecaoeee i?aia?aoa, a oaeaea aeey eco/aiey
noaaeeueiinoe a?aioe a i?ioeanna o?aiaiey, ?ac?aaioaiu iaoiaeeee
ea/anoaaiiiai e eiee/anoaaiiiai aiaeeca. Aiaeec iaoeeo?aoeeea i?iaiaeeee
iaoiaeii OO-niaeo?ineiiee. Aeey oeaieeoa eniieueciaaee iaoiae
ii?aaeaeaiey aai iaiaiiie aieinoe. ?acoeueoaou eco/aiey noaaeeueiinoe
i?aia?aoa iieacaee, /oi a?aioeu “A?aoeaiao” inoathony noaaeeueiuie ia
i?ioyaeaiee 2 eao. Ia i?aia?ao a aeaea a?aioe ia iniiaa i?e?iaeiiai
oeaieeoa iiae oneiaiui iacaaieai “A?aoeaiao” ?ac?aaioaia
ii?iaoeaii-oaoie/aneay aeieoiaioaoeey.

Eeth/aaua neiaa: oeaieeo, ninoaa, ycaaiiue eiaeaen, oaoiieiaey,
noaaeeueiinoue.

Krutskykh T.V. “Technology and Composition Development of Anti-ulcer
Drug in Granules on the Basis of Natural Zeolite”.

The thesis for Master Degree in Pharmacy in speciality 15.00.01- Drug
Technology and Industrial Pharmacy; Ukrainian Academy of Pharmacy;
Kharkov, 1999.

The thesis is a manuscript.

The scientific based composition, technology and methods for component
analysis of the combined drug with anti-ulcer action have been developed
in this thesis. The harmlessness, specific activity of the drug
developed, as well as its stability in the process of storage have been
studied.

Key words: natural zeolite of brand A, composition, technology,
stability, ulcer index.

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