Регуляторний природний пептидний комплекс нирок: отримання, фізико-хімічні властивості, зв’язок з головним комплексом гістосумісності, імунобіологічні

I?I?NOA?NOAI IOI?IIE CAeI?IA”ss OE?A?IE

IAOe?IIAEUeIEE IAAeE*IEE OI?AA?NEOAO ?i.I.I.AIAIIIEUeOess

Ia i?aaao ?oeiieno

OAeE 612.46:577.156+615.2’2/.9

EAEAeAOAA ?AI? IAO?IAE*

?AAOEssOI?IEE I?E?IAeIEE IAIOEAeIEE EIIIEAEN IE?IE:

IO?EIAIIss, O?CEEI-O?I?*I? AEANOEAINO?, CA’ssCIE C

AIEIAIEI EIIIEAENII A?NOINOI?NIINO?,

?IOIIA?IEIA?*I? AOAEOE OA ?IC?IAEA OA?IAEIEIA?*II?

?A*IAEIE

Niaoe?aeuei?noue — 14.03.08 — ?ioiieia?y oa aea?aieia?y

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Ee?a — 1999

Aeena?oaoe?y ? ?oeiien.

?iaioa aeeiiaia ia aac? OeIAeE Oe?a?inueei? iaaee/ii? noiiaoieia?/ii?
aeaaeai??, i.Iieoaaa

Iaoeiaee eiinoeueoaio:

— aeieoi? iaaee/ieo iaoe, i?ioani? Ae?aiiee Aai?a?e Ieeieaeiae/,
caa?aeoth/ee eaoaae?ith ee?i?/ii? ?ioiieia?? Iaoe?iiaeueiiai iaaee/iiai
oi?aa?neoaoo ?i.I.I.Aiaiiieueoey.

Io?oe?ei? iiiiaioe:

— aeieoi? iaaee/ieo iaoe, i?ioani? Eenyiee Ieeiea ?aaiiae/, caa?aeoaa/
a?aeae?eii iae?i?ioiieia?? ?inoeoooo iae?io??o?a?? ?i. A.I.?iiiaeaiiaa
AII Oe?a?ie;

— aeieoi? iaaee/ieo iaoe, i?ioani? Iaeuei?eia Ieaa Oaaein?eiae/,
caa?aeoaa/ eaai?aoi???th ?ioiieia?? Ee?anueeiai iaoeiai-aeine?aeiiai
?inoeoooo ioiea?eiaieia?? ?i. A.?.Eieii?e/aiei;

— aeieoi? iaaee/ieo iaoe, i?ioani? Iaeeaeaa Aaae?i Ieaen?eiae/,
Oe?a?inueeee iaoeiai-i?aeoe/iee oeaio? aiaeie?eiii? o??o?a??,
o?ainieaioaoe?? aiaeie?eiieo i?aai?a oa oeaiei IIC Oe?a?ie.

I?ia?aeia onoaiiaa: ?inoeooo aenia?eiaioaeueii? iaoieia??, iieieia?? oa
?aae?ia?ieia?? IAI Oe?a?ie ?i.Eaaaoeueeiai, eaai?aoi??y ?ioiieia?? oa
aea?aieia??.

Caoeno aeena?oaoe?? a?aeaoaeaoueny 15 ea?oiy 1999 ?ieo i 13.30 aiaeei?
ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.003.04 i?e
Iaoe?iiaeueiiio iaaee/iiio oi?aa?neoao? ?iai? aeaaeai?ea
I.I.Aiaiiieueoey (252057, i.Ee?a, I?iniaeo Ia?aiiae,34).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Iaoe?iiaeueiiai
iaaee/iiai oi?aa?neoaoo ?iai? aeaaeai?ea I.I.Aiaiiieueoey (i.Ee?a, aoe.
Ciieia?/ia 1, noiiaoieia?/iee ei?ion).

Aaoi?aoa?ao ?ic?neaiee 10 aa?aciy 1999 ?ieo.

A/aiee nae?aoa? Niaoe?ae?ciaaii?

?aaee, i?ioani? *a?eania A.A.

ANOOI

Aeooaeueiinoue oaie.

I?ia?an ?ioiieia?? ye ooiaeaiaioaeueii? iaaeeei-a?ieia?/ii? iaoee
a?aei?/ai nooo?aei ?icaeoeii ciaiue i?i ?ieue ?ioiii? nenoaie a
caaacia/aii? aeeoo?ae?yeueiino? i?aai?cio [Aa?oeai?a A.A., 1989; Aooaiei
A.I., 1998; Paul W.E. et al., 1984].

Iai?i ?ioi?iaoe??th i?ae ee?oeiaie niaoe?ae?ciaaieo oeaiei oa i?aai?a oa
ee?oeiaie ?ioiii? nenoaie a?aeaoaa?oueny, ii-ia?oa, ca ?aooiie i?yiiai
eiioaeoo i?ae ?ioiioeeoaie oa ee?oeiaie ia a?oio? ?aoeaioi?ii?
aca?iiae??, ii-ae?oaa, oeyoii iaaeoiaeaeaiiy o ciai?oiueiee?oeiia
na?aaeiaeua aiane?aeie nae?aoe?? aai ?oeiaoe?? ee?oei ?a/iaei, ye?
ci?iththoue ooieoe?iiaeueiee noai ?ioiioeeo?a [Aeiaaa E.A., 1997;
Aaeeaieoaa I.Ae., 1998; Paul W.E. et al., 1984].

A iniia? ?ioi?iaoe?eieo iiae?e, ui iathoue i?noea i?e eiioaeo?
e?ioioeeo?a oa aioeaaii?acaiooth/eo ee?oei, iieeaaeaii aca?iiae?th i?ae
O-ee?oeiiei ?aoeaioi?ii oa aioeaaiiei iaioeaeii, yeee i?acaioo?oueny
iieaeoeaie aieiaiiai eiiieaeno a?noinoi?niino? (AEAN) [Oaeoia ?.I.,
Aeaenaaa E.I., 1998].

Oa ui iieaeoee AEAN ? eeano o?ainii?oothoue ia ee?oeiio iaia?aio
iaioeaei? o?aaiaioe aaniethoii an?o a?ee?a, ye? neioacothoueny o
ee?oei?, caaacia/o? ?ioiio nenoaio caniaii eiio?ieth ee?oeiiiai
ai?noo,cae?enith? iai?oanoaoe?th iiaeo /oaei??aeieo i?iaeoeo?a,
aeaoaeoe?th a?ee?a, ye? cae/aeii ia aeni?anothoueny.

Iieaeoee AEAN ?? eeano ?acii ?c ca’ycaieie iaioeaeaie ni?yiiaothoue
CD4-iiceoeai? O-ee?oeie ca aeaiia ooieoe?iiaeueieie oeyoaie: ii-ia?oa,
oe? ee?oeie «aeiiiiaaathoue» ?ioei aioeaainiaoeeo?/iei e?ioioeeoai
aeeoa?aioe?thaaoeny oa aeoeaoaaoeny (oiaoi ?aae?cothoue oaeia?io
ooieoe?th); ii-ae?oaa, aiie aoaeothoue /oaei??aeiee aioeaai,
i?acaioiaaiee AEAN ??-iiceoeaieie ee?oeiaie aai i?yii, aai ca
aeiiiiiaith ianiaoeeo?/ieo ee?oei — iae?ioaa?a, a?aioeioeeo?a
(?iaeoeoi?ia ooieoe?y).

Iaeii/anii, ooieoe?iiaeueiee noai ?ioiioeeo?a ?aaoeth?oueny ?a/iaeiaie,
ye? iaaeoiaeyoue c niaoe?ae?ciaaieo ee?oei oa i?aai?a. Na?aae oeeo
?a/iaei, ui io?eiaee iacao aiaeiaaiieo ?ioiiiiaeoeyoi??a [Eaoeeineee
N.A., Neiae?oeaa A.N., Ai?iaueaa A.A., 1992] cia/ia i?noea iin?aeathoue
iaioeaei? oa iie?iaioeaei? ?a/iaeie. Na?aae ieo iaea?eueo aea/aieie ?
iie?iaioeaei? oaeoi?e ?inoo (ai?aea?iaeueiee oaeoi? ?inoo, oaeoi? ?inoo
o?iiaioeeo?a, o?ainoi?ioth/? oaeoi?e ?inoo oiui), ?ioa?eaee?ie, ai?iiie
o?iona, oaeoi?e iae?ico iooeei, ?ioa?oa?iie [Eaethiia A.I. e niaao.,
1998].

Ieoaiiy aca?iia?aeiinei ee?oei niaoe?ae?ciaaieo oeaiei oa i?aai?a c
?ioiioeeoaie (acaaae? c ?ioiieie i?aaiaie) iaaoei a?aeiiino? oa
aeooaeueiino? caaaeyee ?iaioai A.A.Aaaa?aie c? ni?aaao. (1975, 1985).
Aoa noi?iiaaiee ie?aiee iai?yiie aeine?aeaeaiue — ?ioiieia?y
?aia?aoeaieo i?ioean?a. A iniia? oeeo aeine?aeaeaiue aoei iieeaaeaii
a?iioaco, ui iaaia e?euee?noue a?eueiiai aioeaaia oeaieie, ui
iaaeoiaeeoue o e?ia, noeioeth? i?iaeoeoe?th e?ioioeeo?a, ye? caeaoi?
a?aoe o/anoue a ?aaaia?aoi?ieo i?ioeanao oeaieie ye ca o?c?ieia?/ieo
oiia, oae ? i?ae /an iioeiaeaeaiiy i?aai?a. Oaeee i?ioean ia?aaeaa/a?
?nioaaiiy iaoai?cio cai?ioiueiai ca’yceo ca o?c?ieia?/ieo oiia a
i?aai?ci? i?ae /an ii?iaeueiiai ooieoe?iioaaiiy i?aai?a.

Oeae iai?yiie aeine?aeaeaiue iaaoa iiaeaeueoiai ?icaeoea a ?iaioao
N.?.?yaiaa c ni?aaao. (1989), ye? i?iaeaiiino?oaaee ui aeey ii?iaeueiiai
a?aeiiaeaiiy no?oeoo?e oa ooieoe?e ie?ie iio??aia o/anoue iniaeeai?
iiioeyoe?? oeiioeeo?a, yea ia? oa?iaio oa?i?iaeueio aeacieneioeeaio?ae?e
o?ainoa?aco (OAeO-iiceoeai? ee?oeie) oa ai?iii?a oeiona. Iaeii/anii,
?acoeueoaoe ?o aeine?ae?a aenoioee ieoaiiy i?i ?a/iaeie ie?ie, ye?
aa?ooue o/anoue a ?ioi?ioaaii? ?ioiii? nenoaie, cie?aia oeiioeeo?a, i?i
ci?io ii?oiooieoe?iiaeueiiai noaio ie?ie.

Oaeei /eiii, ca aeaieie e?oa?aoo?e iaa?aeiii i?i aeanio a?ieia?/io
aeoeai?noue iaioeae?a, ca’ycaieo c iieaeoeaie AEAN, iaiia’ycaio c
i?acaioaoe??th aioeaaia oa cia/aiiy oeeo iaioeae?a a iaoiaaiac?
caoai?thaaiue. A oie aea /an iaioeaee, ye? o?ainii?oothoueny iieaeoeaie
AEAN ia ciai?oiueiee?oeiio iaia?aio, ianooue niaoeeo?/io aeey eiaeiiai
aeaea ee?oei ?ioi?iaoe?th i?i aioo??ee?oeiiee neioac oa i?ioean?ia
a?ee?a. Oe? iac’yniaai? oaeoe ?acii c a?aeiiinoyie i?i o?niee ca’ycie
i?ae nenoaiith ?ioi?oaoa oa caoai?thaaiiyie ie?ie aenoioee
iaiao?aei?noue aea/aiiy oe??? i?iaeaie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie.

Iaaaaeai? a ?iaio? ?acoeueoaoe aeine?aeaeaiue ? naiino?eiei o?aaiaioii
aeine?aeaeaiue ca oaiith IIC Oe?a?ie «I?iaaaeaiiy aeiee?i?/ieo ?nieo?a
oa aea/aiiy iniiaieo iaoai?ci?a ae?? iiaeo e?ea?nuee?o cania?a,
aeaeiaooeo c oaa?eiii? ne?iaeie aeey e?eoaaiiy aooi?ioiieo, o?aaiaoe/ieo
oa iieieia?/ieo caoai?thaaiue i?aai?cio» (N 0195U026214), «?ieue
aeenaaeaino iaioeaea?a?/ii? nenoaie ?aaoeyoe?? a ?icaeoeo oeiiaeo
iaoieia?/ieo i?ioean?a oa oeyoe ?? a?aeiiaeaiiy ?ioi?iaoe?eieie
iieaeoeaie iie?iaioeaeii? i?e?iaee» (Oeo? oaie OE 91.70) N UA01001570?,
AeEIO Oe?a?ie «?ieue aeenaaeaino nenoai iie?iaioeaeii? ?aaoeyoe?? a
?icaeoeo iaoieia?/ieo noai?a, ca’ycaieo c ae??th iani?eyoeeaeo oaeoi??a
ciai?oiueiai na?aaeiaeua ? oeyoe ?o ei?aeoe?? i?aia?aoaie iie?iaioeaeii?
i?e?iaee» N 0193U007913, ?i?oe?aoeaii? iaoeiai-aeine?aeii? ?iaioe
«Aea/aiiy ca’yceo aooi?ioiieo caoai?thaaiue ie?ie oa oeaio?aeueii?
ia?aiai? nenoaie c iieaeoeaie aieiaiiai eiiieaeno a?noinoi?niino?
ia?oiai eeano» N aea?ae?a?no?aoe?? 0195U026216.

Iaoa oa caaea/? aeine?aeaeaiiy.

Iaoith oe??? ?iaioe noaei aecia/aiiy ?ioiia?ieia?/ieo aoaeo?a oa ca’yceo
c iieaeoeaie aieiaiiai eiiieaeno a?noinoi?niino? i?e?iaeiiai iaioeaeiiai
eiiieaeno ie?ie aeey ?ic?iaee iiai? e?ea?nueei? ?a/iaeie.

O a?aeiia?aeiino? c iaoith ?iaioe aoee aenoioo? ianooii? caaea/?:

1. ?ic?iaeoe niin?a aeno?aeoe?? iaioeaeiiai eiiieaeno c oeaiei ie?ie,
ioa?aeoa?ecoaaoe eiai ca o?ceei-o?i?/ieie aeanoeainoyie.

2. C’ynoaaoe ca’ycie iaioeaeiiai eiiieaeno ie?ie c iieaeoeaie AEAN ? oa
?? eean?a.

3. Aea/eoe ae?th iaioeaeiiai eiiieaeno oeaiei ie?ie ia iieacieee
?ioi?oaoo, ianiaoeeo?/ii? ?acenoaioiino?, aaiinoaco oa ia?aeeniiai
ieeneaiiy e?i?ae?a ca o?c?ieia?/ieo oiia.

4. Aea/eoe ae?th iaioeaeiiai eiiieaeno oeaiei ie?ie a oiiaao ?icaeoeo
iaoieia?/ieo noai?a iia’ycaieo c aooi?ioiiei iioeiaeaeaiiyi ie?ie a
?cieueiaaiiio oa eiia?iiaaiiio aa??aioao oa ca oiia aeio?ainieaioaoe??
ie?ie.

5. Aeyaeoe niaoeeo?/i? oa ianiaoeeo?/i? ?ene ae?? iaioeaeiiai eiiieaeno
ie?ie a ii??aiyii? c iaioeaeiei eiiieaenii ?ioiai i?aaio.

6. Aecia/eoe iiaeeea?noue ca’ycoaaiiy iaioeae?a ie?ie c ?ioeie
iaioeae-o?ainii?ooth/eie iieaeoeaie.

7. Aea/eoe caaaeueiee ieai no?oeoo?ii? i?aai?caoe?? iaioeaeiiai
eiiieaeno ie?ie, neioacoaaoe eiai ooo/i? aiaeiae oa aeine?aeeoe ?o
oa?aiaaoe/iee aoaeo ca oiia aenia?eiaioaeueii? aooi?ioiii? iaoieia??
ie?ie.

Iaoeiaa iiaecia.

Aia?oa ?ice?eoa ?ioiia?ieia?/ia aeoeai?noue iaioeae?a aieiaiiai
eiiieaena a?noinoi?niino?, yea a?aee?eaa? iia? oeyoe iaoiaaiaoe/ii?
oa?ai?? aooi?ioiieo caoai?thaaiue, aea? iiaeeea?noue ei?aaoaaoe i?ioeane
?aaaia?aoe?? oeaiei.

Iieacaii, ui iaioeaee aieiaiiai eiiieaeno a?noinoi?niino? iathoue aeanio
a?ieia?/io aeoeai?noue, ia iaiaaeaio i?acaioaoe??th aioeaai?a. Oaeee
iaioeaeiee eiiieaen caeaoai iiaeoethaaoe aeoeai?noue e?ioioeeo?a
ia?eoa??eii? e?ia? (ia?aaaaeii, O-ee?oei) oa aeeeeeaoe
ii?oiooieoe?iiaeueio ia?aaoaeiao a oeion?. A oiiaao aenia?eiaioaeueii?
aooi?ioiii? iaoieia?? ie?ie iaioeaeiee eiiieaen caaacia/oaaa
a?aeiiaeaiiy ?ioiieia?/ii? oiea?aioiino? oa ii?oiooieoe?iiaeueiiai noaio
ie?ie. Iieacaia o/anoue ?ioa?eaee?ia-2 o ?aae?caoe?? aoaeo?a iaioeaeiiai
eiiieaena.

Aia?oa aea/aii caaaeueiee ieai no?oeoo?ii? i?aai?caoe?? iaioeaeiiai
eiiieaeno ie?ie, ia iniia? yeiai neioaciaaii o?e ooo/ieo
iaioeaea-aiaeiaa, ye? iathoue ??ciiai nooiaiy ae?aaeaiino? oa?aiaaoe/iee
aoaeo ca oiia aenia?eiaioaeueii? aooi?ioiii? iaoieia?? ie?ie.

I?aeoe/ia oe?ii?noue ?iaioe.

Aeiaeaeaiee niin?a aeno?aeoe?? a?ieia?/ii aeoeaieo iaioeae?a
c oaa?eiii? ne?iaeie iiaea aooe aeei?enoaiee aeey noai?aiiy iiaeo
e?ea?nueeeo i?aia?ao?a. I?e?iaeiee iaioeaeiee eiiieaen ie?ie ia?
ae?aaeaio oa?aiaaoe/io aeoeai?noue i?e aenia?eiaioaeuei?e aooi?ioii?e
iaoieia?? ie?ie, ui a?aeia?aaea? ia?niaeoea-i?noue eiai aeei?enoaiiy ye
e?ea?nueei? ?a/iaeie.

?ic?iaeaii i?aeoe/iee i?aeo?ae aei neioaca iaioeae?a-aiaeia?a i?e?iaeieo
iaioeaeieo noi?oae, ye? caa??aathoue a?eueo?noue aeanoeainoae noi?oae.
Neioaciaaii o?e iaioeaea, ye? iathoue cia/io oa?aiaaoe/io aeoeai?noue
i?e aooi?ioii?e iaoieia?? ie?ie, ui iiaeooue ?icaeyaeaoenue ye
iioaioe?ei? e?ea?nuee? ?a/iaeie.

Ai?iaaaeaeaiiy iaoeiaeo ?ic?iaie.

*anoeia ?acoeueoao?a aeei?enoiao?oueny o iaa/aeueiiio i?ioean? ia
eaoaae?ao ii?iaeueii? o?c?ieia??, i?e?ia?ieia?? oa ?ioiieia??,
caaaeueii? oa?iaeieia?? Oe?a?inueei? iaaee/ii? noiiaoieia?/ii?
aeaaeai??.

Iaaaaeai? a ?iaio? ?acoeueoaoe aeine?aeaeaiue eyaee a iniiao noai?aiiy
iiai? iaioeaeii? e?ea?nueei? ?a/iaeie «Iao?ieao» ca oaiith IIC Oe?a?ie
«I?iaaaeaiiy aeiee?i?/ieo ?nieo?a oa aea/aiiy iniiaieo iaoai?ci?a ae??
iiaeo e?ea?nuee?o cania?a, aeaeiaooeo c oaa?eiii? ne?iaeie aeey
e?eoaaiiy aooi?ioiieo, o?aaiaoe/ieo oa iieieia?/ieo caoai?thaaiue
i?aai?cio» (N 0195U026214).

Cai?iiiiiaaiee niin?a aeno?aeoe?? iaioeaeiiai eiiieaeno c oaa?eiieo
oeaiei oni?oii aeei?enoaiee aeey ?ioeo oeaiei, ui aeaei ciiao noai?eoe
iia? e?ea?nuee? ?a/iaeie «Aa?i?eao» (Iaoaio Oe?a?ie N5743), yeee aaea
i?ioiaeeoue ia?oo oaco ee?i?/ieo aei?iaoaaiue oa eiiieaen iaioeae?a
i?aeoeoieiai? caeice (??oaiiy i?i aeaea/o iaoaioo 94052070 a?ae
23.03.1995).

Iniaenoee aianie aeena?oaioa o ?ic?iaeo iaoeiaeo ?acoeueoao?a, ui
aeiinyoueny ia caoeno.

Aaoi?ii aeena?oaoe?? ?ic?iaeaii i?ia?aio aeine?aeaeaiue, iniaenoi
aeeiiai? on? o?ceei-o?i?/i?, ?ioiieia?/i?, oeeoio?i?/i?, a?io?i?/i?,
a?noieia?/i? oa noaoenoe/i? aeine?aeaeaiiy. Aeena?oaioii i?iaaaeaii
naiino?eii aiae?c anueiai io?eiaiiai oaeoe/iiai iaoa??aea, ?ic?iaeaii
iniiai? iieiaeaiiy oa aeniiaee ?iaioe. Iniaeeaa iiaeyea ni?a?ia?oieeai
Oeaio?aeueii? iaoeiai-aeine?aeii? eaai?aoi??? I.I.Aia?ia?e, I.A.Aiaia?/,
I.I.Aaeei oa anenoaioo eaoaae?e ii?iaeueii? o?c?ieia?? Oe?a?inueei?
iaaee/ii? noiiaoieia?/ii? aeaaeai?? E.A.Aani?iie ca oaoi?/io aeiiiiiao.
Neioac iaioeae?a-aiaeia?a aeeiiaii aeieoi?ii S.Stevanovich a eaai?aoi???
i?io. H.G-.Rammensee (I?iaoeueeee oeaio? aeine?aeaeaiue ?aea,
i.Aaeaeaeueaa?a) ca ui i?eiineii iiaeyeo.

Ai?iaaoe?y. Aieiai? iieiaeaiiy aeena?oaoe?eiiai aeine?aeaeaiiy
aeiiia?aeaeenue oa iaaiai?thaaeenue ia iao/ii-i?aeoe/ii? eiioa?aioe??
«Iiene iiauo eaea?noaaiiuo n?aaenoa e eo eniieueciaaiea a eeeieea»
(*?oa, 1990); i?aeaoc?anuee?e eiioa?aioe?? iieiaeeo a/aieo «O?c?ieia?y
oa iaoieia?y ia?aeeniiai ieeneaiiy e?i?ae?a, aaiinoaca oa ?ioiiaaiaca»
(Iieoaaa, 1990-1997); Y? c»?cae? oa?iaeieia?a O?N? (Oa?e?a, 1990); O???
c’?cae? Oe?a?inueeiai o?c?ieia?/iiai oiaa?enoaa (Oa?e?a, 1990);
Ananithci?e eiioa?aioe?? iieiaeeo a/aieo 225 ?ie?a ? II? (Iineaa, 1990);
iaoeia?e eiioa?aioe?? iieiaeeo a/aieo ? niaoe?ae?no?a (Aeiiaoeuee,
1990); Ananithci?e eiioa?aioe?? «Oeceieiaey e iaoieiaey aaiinoaca»
(Iieoaaa,1991); YI Oe?a?inueeiio a?io?i?/iiio c’?cae? (Ee?a, 1992);
I?aeia?iaeiiio n?iiic?oi? «Iaioeaeiua aei?aaoeyoi?u-oeeoiiaaeeiu»
(Naieo-Iaoa?ao?a, 1992); I?aeia?iaeiiio n?iiic?oi?
«Nenoaiii-aioenenoaiiay ?aaoeyoeey a aeeaie e iaaeeaie i?e?iaea» (Ee?a,
1993); ?anioae?eainuee?e iaoeia?e eiioa?aioe?? «Aeooaeuei? ieoaiiy
aeiaaiaoeee oa ?ioiieia??» (Iieoaaa, 1994); IY eiioa?aioe??
«Aeiaioeieneaeaio»(Iineaa, 1993); I?aeia?iaeiiio n?iiic?oi? «Oeceieiaey
e iaoieiaey aaiinoaca» (N?ioa?iiieue, 1994); ? Iaoe?iiaeueiiio c’?cae?
oa?iaeieia?a Oe?a?ie (Iieoaaa,1995); ? Eiia?an? oaaea?aoe??
?a?iiaenueeiai o?c?ieia?/iiai oiaa?enoaa (Iaano??o, 1995), ia can?aeaii?
eaai?aoi??? i?eeeaaeii? ?ioiieia?? I?iaoeueeiai oeaio?o aeine?aeaeaiue
?aeo (Aaeaeaeueaa?a,1994), ? Iaoe?iiaeueiiio eiia?an? c ee?i?/ii?
?ioiieia?? oa aea?aieia?? (Aeoooa, 1998), Neiiic?oi? c a?io?i?? oa
iieaeoey?ii? a?ieia?? (Eaia, 1998).

Ioae?eaoe??.

Ca oaiith aeena?oaoe?? iaae?oeiaaii 35 ?ia?o.

Ianya ?iaioe.

Aeena?oaoe?th aeeeaaeaii ia 258 noi??ieao ae?oeiaaiiai oaenoo
? aiia neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, aeaae «Iaoa??aee oa
iaoiaee aeine?aeaeaiue», 6 aeaa aeanieo aeine?aeaeaiue, iaaiai?aiiy
io?eiaieo ?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo
e?oa?aoo?e oa aeiaeaoeo.

?iaioa i?noeoue 36 oaaeeoeue, 21 iaethie?a ? 42 i?e?ioioi.
Nienie e?oa?aoo?e i?noeoue 125 a?o/eciyieo ?ia?o ? 118 ?ia?o ?iicaiieo
aaoi??a.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

IAOA??AEE OA IAOIAeE AeINE?AeAEAIIss

Aenia?eiaioaeueia /anoeia aeine?aeaeaiue aeeiiaia ia 184 a?eeo
uo?ao e?i?? Wistar, 12 ii?nueeeo naeieao, 52 a?eeo ieoao, 30
cieioenoeo oii’yeao oa 4 e?ieyo.

Eaai?aoi?ieo oaa?ei oo?eioaaee a oiiaao a?aa??th ia noaiaea?oiiio
?aoe?ii? oa?/oaaiiy o a?aeiia?aeiino? c «Naieoa?iuie i?aaeeaie ii
ono?ienoao, iai?oaeiaaieth e niaea?aeaieth
yenia?eiaioaeueii-aeieiae/aneeo eeeiee (aeaa?eaa)».

*anoeia niinoa?aaeaiue aoea i?iaaaeaia ia e?ia? 20 aeiii??a ? e?ia? 15
oai?eo ia o?ii?/iee aeiia?oeiiao?eo ia aac? a?aeae?eaiiy iao?ieia??
Iieoaanueei? iaeanii? ee?i?/ii? e?ea?i?.

Ia’?eoaie aeine?aeaeaiue aoee e?ia, ieacia, ne?iaaoea e?ia?
aenia?eiaioaeueieo oaa?ei,a oaeiae e?ia ? na/a caei?iaeo aeiii??a oa
oai?eo.

Aeey ae??oaiiy iinoaaeaieo caaea/ aoee a?aeoai?ai? ianooii?
aenia?eiaioaeuei? iiaeae?.

Aino?ee no?ann a?aeoai?thaaee o aeaeyae? aino?iai
aii-oe?eii-aieueiaiai no?ano i/?eoaaiiy ca iaoiaeeeith [Disiderato O.,
McKinnon J.R.,1974]. Nooue iaoiaeeee iieyaa? a iiaeaii? aeaeo?e/ieo
?ic?yae?a ia eaiee uo??a o aeiaaeeia? a?ae??cee /ano, ui i?eiooo? oaa?ei
iino?eii ci?ithaaoe i?noea ciaoiaeaeaiiy. Oaa?eiai aeine?aei? ?a/iaeie
(iaioeaeiee eiiieaen ie?ie oa oea?oeiieaci?i) aaiaeeee ca 2 aiaeeie aei
ii/aoeo no?ana oa iae?aco i?ney iueiai. Caa?e oaa?ei i?iaiaeeee ca 2
aiaeeie i?ney no?ano.

Aooi?ioiiee iao?eo o oaa?ei ?iaeoeoaaee i?ae /an aaaaeaiiy noniaic??
aooieia?/ii? ie?ee a iiaiiio aae’thaaio? O?aeiaea («?aaeiiieaen», *eoa)
o?e?aciai ia i?ioyc? o?ueio oeaei?a [Kment A. et al., 1976]. Aeey /iai
aiooaaee aiaeii-nieueiaee aeno?aeo ei?eiai? ?a/iaeie ie?ie, ci?ooaaee
eiai c aae’thaaioii 1:1 aei ooai?aiiy no?eei? aioeuen??. Aioeuen?th
aaiaeeee i?aeoe??ii c ?ic?aooieo 0,5 ie ia oaa?eio. Ca oeaeaeaiue i?ney
inoaiiuei? ?ioi?caoe?? ii/eiaee aenia?eiaioaeueio oa?ai?th iaioeaeiei
eiiieaenii ie?ie a aeic? 0,1 ia/ea.

Iie?eiiiiiaioia ?ioiiiaoieia?y a?aeoai?thaaeanue aaaaeaiiyi oaa?eiai
noniaic?? aooieia?/ii? ie?ee a aooieia?/i?e ne?iaaooe? [Oa?iaoia O.O.,
A?unei A.A., 1988]. Uo??a ?ioi?coaaee aaaaeaiiyi i?aia?aoo 0,5 ie ia
oaa?eio i’yoee?aoii c ?ioa?aaeii 3 aei? i?aeoe??ii a iaeanoue /a?aaa. Ca
oeaeaeaiue i?ney inoaiiuei? ?ioi?caoe?? ii/eiaee aenia?eiaioaeueio
oa?ai?th iaioeaeiei eiiieaenii ie?ie a aeic? 0,1 ia/ea.

Oi?eaoa?aeueia iao?aeoii?y c aeinoaoe/iith o?ainieaioaoe??th ie?ee
aeeiioaaeanue oaeei /eiii. O uo??a-naioe?a e?i?? Wistar aaaith 180-200 a
i?ae aaenaiaeiaei ia?eicii aeaeaeyee i?aao ie?eo, iio?i aeiaaiio ie?eo
ai?uoaaee o aaeeeee naeueiee, o?ainieaioao ie?ee aeaeainoethaaee.
Ia?ai?uaiiy o?ainieaioao?a ? ii??aiyiiy i?iaiaeeee i?ae oaa?eiaie
iiia?ii, oaeei /eiii, uo?e a ia?? (oiaoi a eiio?ieuei?e oa aeine?aei?e
a?oiao) a?ae??ciyeeny ca iaeieie aaiaie a?noinoi?niino?. Oaa?eie
eiio?ieueii? a?oie io?eioaaee ?i’?eoe?? 0,2 ie noa?eeueiiai
o?c?ieia?/iiai ?ic/eio iao??y oei?eaeo, a aeine?aeii? — 0,1 ia/ea
iaioeaeiiai eiiieaeno ie?ie. Ia?oo ?i’?eoe?th i?iaiaeeee iae?aco i?ney
iia?aoe??. Ooieoe?iiaeuei? ? ii?oieia?/i? ci?ie a ia?aio?i? ie?ie
ioe?ithaaee ca 4 aiaeeie, 1 oa 4 aeiae i?ney iia?aoeaiiai ao?o/aiiy.
Ae?o?ac ?iaeoeoaaee aaaaeaiiyi uo?ai a oeoiie aiaeii?iaiaeii? aiaee c
?ic?aooieo 5% a?ae aaae o?ea. Na/o cae?aee ia i?ioyc? 2 aiaeei a
niaoe?aeueieo ee?oeao. A na/? oa ne?iaaooe? e?ia? aea/aee ianooii?
iieacieee: ae?o?ac, aene?aoe?th a?eea, eiioeaio?aoe?th oa aene?aoe?th
e?aaoei?io, iao??th, eae?th, eeoai/eiao o?eueo?aoe?th, iao??e-eae??aee
eiao?oe??io na/?.

Aianaiiy o e?ia oai?eo ia aeiia?oeiiao?eo iaioeaeiiai eiiieaeno ie?ie
i?iaiaeeeinue a aeic? 10 iea/ie a i?i?iaeueiiio ia’?i? noa?eeueiiai
o?c?ieia?/iiai ?ic/eio oa ?ieoaaoe?? 30 oaeeei. Eiio?ieai aoee i?iae,
eoaee aiineee eeoa ?ic/eiiee.

Niaeo? iaioeae?a ie?ie i?e iaoieia?yo aeine?aeaeoaaany ca aeiiiiiaith
iaa?iaiioaciai? aenieiaoaeoeaii? ??aeeiii? o?iiaoia?ao??.

Aca?iiae?y iaioeae?a c oaia?iiaie Hsp70 aeine?aeaeoaaeanue oaeei /eiii.
Aeae?eaiiy Hsp70 i?iaiaeeee c ie?ie ieoae BALB/c [Udono H., Srivastava
P.K.,1993]. Iio?i io?eiaiee aeno?aeo Hsp70 aoa aea?/? ia?iaeaiee 10mM
AOO ii 30 oaeeei ia iao?iiao «Centricon-10». Aeno?aeoe iaioeae?a, ye?
aoee ca’ycai? c Hsp70, aoee c?a?ai? oa neiioeaio?iaai? i?ae aaeooiii
Speed Vac (Savant Instruments Inc., Farmingdale,NY) oa ia?a?ic/eiai? a
0,1% ?ic/ei? o?iooi?ioeoiai? eeneioe (Fluka). Iaioeaei? aeno?aeoe
aiae?coaaee iaoiaeii AA?O ia o?iiaoia?ao? SMART tm SYSTEM, LKB,
«Pharmacia», Sweden. Iio?i aei a?aeieoeo a?ae AOO a?eueieo a?ae
ca’ycaieo iaioeae?a iieaeoe Hsp70 aoei aeiaaaeaii iaioeaeiee eiiieaen
ie?ie ? i?ney 30 oaeeei ?ieoaaoe?? iaca’ycai? iaioeaee aoee a?aeieo?
0,15I oei?eaeii iao??y. I?ney /iai aoei i?iaaaeaii aeno?aeoe?th
ca’ycaieo iaioeae?a ye iienaii aeua.

Aiae?c ai?iieeneioieo iine?aeiaiinoae iaioeae?a i?iaiaeeee ca iaoiaeii
Aaeiaia ia aaoiiaoe/iiio naeaaiaoi?? 120A «Applied Biosystems» (NOA).
I?e oeueiio oeenoa?i ia iiaeeo?eoaaany ? oiio ia aeaoaeooaaany.

Ae?y ie?aieo iaioeaeieo o?aeoe?e ie?ie ia i?ie?oa?aoe?th ee?oei
aeine?aeaeoaaeanue ia nieaiioeeoao ieoae BALB/c. A 96-eoieiaee ieaioao c
U-ia?aciei aeiii aiineee noniaic?th nieaiioeeo?a a eiioeaio?aoe?? 400000
ia eoieo. Aeei?enoiaoaaee na?aaeiaeua RPMI-1640 («Gibco BRL»,
Oioeaiae?y) c aeiaeaaaiiyi 10% aia??iiaeueii? oaey/i? ne?iaaoee (C.C.Pro
GMBH,I?ia//eia). I?ie?oa?aoe?th ?iaeoeoaaee aeiaeaaaiiyi eiieaiaaae?ia A
(EiiA) aei e?ioeaai? eiioeaio?aoe?? 10 iea/ie. C ii/aoeii ?ieoaaoe?? a
eoiee aiineee iaioeaei? o?aeoe?? , ca 48 aiaeei — 0,5 ieEe 3I-o?i?ae?ia
a ianyc? 50 iee. Oa?aanoa? cae?enithaaee ca 72 aiaeeie i?ney ii/aoea
?ieoaaoe?? a aaoiiaoe/iiio ?aaeei? ia neeiaieieiiieo o?eueo?ao 1450-421
Printer Filtermat A c oaa?aeei noeeio?eyoi?ii 1450-441 MeltiLex tm A oa
i?ae?aooieii ia A-e?/eeueiee? MicroBeta tm («Wallac Oy», O?ieyiae?y).

E??i oiai, aeine?aeaeaii aieea ie?aieo o?aeoe?e ia
?ioa?eaee?i-2(?E-2)-?iaeoeiaaio i?ie?oa?aoe?th ee?oei e?i?? CTLL
(European Collection of Animal Cell Cultures, UK). Aeey eoeueoeaoaaiiy
aeei?enoiaoaaee na?aaeiaeua RPMI-1640 c 10% oaey/i? ne?iaaoee c
aeiaeaaaiiyi 10% aeaooaeiaiaiai noia?iaoaioo EiiA-?iaeoeiaaii? noniaic??
nieaiioeeo?a. 3I-o?i?ae?i oa o?aeoe?? aiineee ca iaaaaeaiith aeua
noaiith.

A?ineioac AeIE a oeaieiao aeine?aeaeoaaany iaoiaeii aeeth/aiiy
?aae?iaeoeaii? i?oee 3I-o?i?ae?ia.

Caaaeueiiaeciai? ?ioiieia?/i? iaoiaee aeieeaaeii iienai? a oeeoiaai?e
e?oa?aoo??. O?aaa coieieoeny eeoa ia aeayeeo iaeia?aeiieo iaoiaeeeao. O-
? B-e?ioioeeoe o oaa?ei (a?e? uo?e oa ii?nuee? naeiee) aecia/aee
iaoiaeii ?icaoeiooai?aiiy c aooieia?/ieie a?eo?ioeeoaie iaaaioaaeaieie
aioene?iaaoeaie, ui aoee io?eiai? aei oeaiei oeiona oa e?ioaoe/ieo
aoce?a [Binaghi R.A. et al.,1975].

Aecia/aiiy iaia?aiieo ia?ea??a e?ioioeeo?a ethaeae i?iaiaeeee iaoiaeii
iai?yii? oethi?anoeaioe?? c iaeii/aniei eiio?ieai a oaciaiio eiio?ano?
ia i?e?ineii? «ETHIAI-?8» (EIII, ?in?y). Aeei?enoiaoaaee IEA LT3, LT4,
LT8, LT22 oa LT-DR ae?iaieoeoaa ?inoeoooa ?ioiieia?? IIC ?in?? aei CD3,
CD4, CD8, CD22 oa HLA-DR. ?ic?aoiaoaaee na?aaei?e oeeoio?i?/iee
eiao?oe??io.

?ioiiia?ieneaeacia aecia/aiiy eieae?caoe?? ?ioiiaeiaoe?i?a a oeaieiao
ie?ie i?iaiaeeee ca aeiiiiiaith aioe-?ioiiaeiaoe?iiaeo aioeo?e i?/aieo
ia?ieneaeacith.

Aooiaioeo?ea aei oeaiei ie?ie aeine?aeaeoaaee iaoiaeii iai?yii?
aaiaaethoeiaoe?? c a?eo?ioeeoaie aa?aia, iaaaioaaeaieie aioeaaiii
ie?eiai? oeaieie [O?eiaeue A., 1987].

Aooiaioeo?ea aei ne?iaaoeiaiai IgG aeine?aeaeoaaee iaoiaeii iai?yii?
aaiaaethoeiaoe?? c a?eo?ioeeoaie aa?aia, iaaaioaaeaieie i?aia?aoii IgG
uo??a («?aaeiiieaen», *eoa) [O?eiaeue A., 1987].

Aeey i?iaaaeaiiy a?noieia?/ieo aeine?aeaeaiue oeaieiiee iaoa??ae
o?enoaaee a 10% iaeo?aeueiiio oi?iae?i? oa 2,5 % caaooa?aiiio ?ic/ei?
aeooa?iaiai aeueaeaa?aeo, iio?i ca noaiaea?oieie iaoiaeeeaie caeeth/aee
a ia?ao?i, c??ce caaa?aethaaee aai-aic?iii, ii Iaei??.

A?aoiaoth/e ooieoe?iiaeueio ?aei?noue iniiaieo nenoai ?acenoaioiino?
e?ia? aoei iaiao?aeiei aeine?aeeoe iieacieee ia?aeeniiai ieeneaiiy
e?i?ae?a oa aaiinoaco. Aeei?enoai? caaaeueiiaeciai? iaoiaeeee iaaaaeai?
o oaaeeoe? 1.

Oaaeeoey 1

Aeei?enoai? caaaeueiiaeciai? iaoiaee aeine?aeaeaiiy

N i/iIieacieee, ui aea/aeenyNoano?aoAaoi?e iaoiaeee1O- ? A-e?ioioeeoe,
O-oaeia?e,O-noi?ani?e, I-ee?oeie

e?ia (ethaee)Eaaaaeaa E.A., Iiiyeeia E.Ae., 19902O- ? A-e?ioioeeoee?ia
(oaa?eie)Binaghi R.A.,19753?iioiioethi?anoeaioe?ye?ia, oeaieieO?eiaeue
A., 19874?ioiiaeiaoe?ie A,M,Gne?iaaoea*a?iioainoiaa A.A., 19755INO
-oano,e?iaIaaiaa A.N. ,19836EEA-oanoe?iaIeaa?aaneee A.A.,

19787Oaaioeeoice?iaHerscowitz H.B., 19818?aaeoe?y aeanoo?ainoi?iaoe??
e?ioioeeo?a

e?iaO?eiaeue A.,19879Eeiaoeea iaeiie/aiiy IAeAe?iaAeaaeeie?ia TH.A.,
A?/aeia A.E. ,197210Niiioaiiee aaiie?c a?eo?ioeeo?a e?iaNie?e/aa A.A. e
ae?.,1979; Jager F.S. 196811Ae??iia? eii’thaaoeieaciaAine?anaineee
I.I.,Ooiaiia A.A., 198212NIAee?iaA?onia I.N.e
ae?.,197613Eaoaeacae?iaA?oeiiaa I.A., 198814Oea?oeiieaci?iieaciaEiea
A.A. e ae?., 198215Aa?aaaoe?y o?iiaioeeo?aieaciaEthnia A.A.,

Aaeionia TH.A., 197116*an ?aeaeueoeeo?eaoe??ieaciaBergerhof H.D., Roka
L. 195417I?io?iia?iiaee /anieaciaQuick A.J. 196618O?iia?iiaee
/anieaciaBiggs R.M.,19Eaie?iiaee /anieaciaAaeoaea A.I.e
ae?.198020Eaoae?iiaee /anieaciaAa?eaaai C.N. 197521A*O*ieaciaBiggs
M.,22Aioeo?iia?i-III ieacia Hensen A.,23O?a?eiiaaiieaciaEioiaueeiaa
I.A., Oaaei?iaa C.Ae., 196624O?a?eiie?c aoaeiaoe?i?aieaciaAiae?aaiei
A.A.

Io?eiaiee oeeo?iaie iaoa??ae aoa noaoenoe/ii ia?iaeaiee ia IAAI IBM
PC/AT-286 «Omega». I?iaiaeeee ia/eneaiiy na?aaeiuei? a?eoiaoe/ii? (I),
na?aaeiueieaaae?aoe/iiai a?aeoeeaiiy (m), iiieeee na?aaeiuei?
a?eoiaoe/ii? (i), a??ia?aei?noue io?eiaieo ?acoeueoao?a ioe?ithaaee ca
eiao?oe??ioii No’thaeaioa (t). Ii?iaeuei?noue ?iciiae?eo aaee/ei
ioe?ithaaee ca iieacieeaie P(t), Q(t), R(t), ?ic?aoiaaieie ca
noaiaea?oiith i?ia?aiith i?e?ieaeueeoeyoi?a «Citizen-SRP-175». *anoeio
aeaieo ia?iaeyee c aeei?enoaiiyi aeene??i?iaioiiai aiae?co.

?ACOEUeOAOE OA ?O IAAIAI?AIIss

O a?aeiia?aeiino? c caaea/aie ?iaioe iaie aoei ?ic?iaeaii iaoiae
aeno?aeoe?? a?ieia?/ii-aeoeaieo ?a/iaei c oeaieie ie?ie. A iniiao
iaoiaea aoei iieeaaeaii aeine?aeaeaiiy O.Rotzschke oa K.Falk (1991), ui
aei aeno?aeoe?? iaioeae?a aieiaiiai eiiieaeno a?noinoi?niino?. Iaoiae
iieyaa? a ciaaee?aii? oa ia?i?ae?caoe?? iaia?ai ee?oei ei?eiai? ?a/iaeie
ie?ie, aeno?aeoe?? i?aai?/iith eeneioith a i?enooiino? aeaioaaeaioieo
eao?ii?a c ianooiiith i?aoeei?oaoe??th iaioeaeieo ?a/iaei oa ?o
i/euaiiyi.

Oaeee aeno?aeo aeaaaa iiceoeaio a?o?aoiao ?aaeoe?th, iaa niaeo?
iiaeeiaiiy a OO-iaeano? c iaeneioiii 210-220 ii, oa?aeoa?iee aeey
iaioeaeiiai ca’yceo. I?ae /an ii??aiyiiy AA?O-niaeo?o io?eiaiiai
aeno?aeoo c aeno?aeoaie, io?eiaieie ca iaoiaeii O.Rotzschke oa K.Falk
(1991) ciaeaeaii ca?aei?noue oeeo iaioeaeieo noi?oae aeey HLA-DR5 oa
DR1. I?ae /an aaeue-o?iiaoia?ao?? aeyaeaii aea? iniiai? o?aeoe?? c
iieaeoey?iith ianith 4 oa 8 kD, aeaeo?ioi?ac a iie?ae??eai?aeiiio aae?
aeyaea /ioe?e iniiai? o?aeoe??, iaeiae, ?o oi/io iano c’ynoaaoe ia
aaeaeinue.

Aea/aiiy ai?iieeneioiiai neeaaeo i?e?iaeiueiai iaioeaeiiai eiiieaeno
ie?ie iieacaei aenieo a?aeiinio e?euee?noue aeooai?iiai?, ania?aa?iiai?
eeneio, a?a?i?io oa e?c?io. ?aeaioeo?eaoe?y aeayeeo o?aeoe?e, ye?
ia?aaaaeathoue o iaioeaeiiio aeno?aeo?, iieacaea iayai?noue oaeeo
iaioeae?a: ?ineeii-eaioetha aaiiaeia?io (55-66, 56-66), aeueoa-eaioetha
aaiiaeia?io (48-61), oa?ea?o?i (1-20). Iaea?eueo oe?eaaa iayai?noue
o?aaiaio?a aeueoaoa ?ineeii-eaioetha?a aaiiaeia?ia, oiio ui ie?ea a
c??eiio a?oe? ia i?iaeoeo? aaiiaeia?i, oei a?eueo ?ineeii-eaioetha
(i?iaeoeo?oueny ia ii/aoeo aia??iiaeueiiai ia??iaea). Iayai?noue a
iaioeaeiiio aeno?aeo? iaioeae?a, ui ? o?aaiaioaie a?ee?a, ye? cae/aeii
ia aeni?anothoueny, ? oa?aeoa?iith iciaeith iaioeae?a, ca’ycaieo c
iieaeoeaie AEAN [ Rudensky A. Yu. et al., 1991; Wilson I.A., Fremont
D.H., 1993; Demotz S., 1993; Tsomides T.J.,Eison H.N., 1993]. Oeae
aeniiaie i?aeoaa?aeaeo?oueny ciaeaeaiith iaie ca?aei?noth
o?iiaoia?ao?/ieo niaeo??a i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie oa
iaioeae?a, aeae?eaieo c iieaeoe AEAN (ia?aaaaeii AEAN ? eeano).

Oaeei /eiii, ?ic?iaeaiee iaie iaoiae aeno?aeoe?? aeicaiey? iaea?aeoaaoe
iaioeaeiee eiiieaen, yeee iaaeaiee ia?aaaaeii iaioeaeaie aieiaiiai
eiiieaeno a?noinoi?niino?.

A?aoiaoth/e, ui iaioeaee AEAN aieiaiei /eiii aa?ooue o/anoue a eiioaeo?
oa iiaeaeueoeo ?aaeoe?yo i?ae O-ee?oeiiei ?aoeaioi?ii oa iieaeoeith
AEAN, ie aea/eee aieea io?eiaieo iaie iaioeae?a ia aeni?an?th aeayeeo
iieaeoe ia iiaa?oi? e?ioioeeo?a.

Io?eiai? ?acoeueoaoe na?ae/aoue, ui iaioeaeiee eiiieaen aieiae??
aeicicaeaaeiith aeoeaoth/ith ae??th ia O-ee?oeie, i?ae eiai aieeaii
niinoa??aaeanue ci?ia aeni?an?? niaoeeo?/ieo ?aoeaioi??a, ?o
ia?aa?oioaaiiy. C?inoaea aeni?an?y CD3, CD4 (i?aeaeuoaaeanue e?euee?noue
eai?ia?a, iao/?a), CD8 (oa?aeoa?ii ciaioaiiy /enea eeanoa??a c i?oeiith
oethi?anoeaioe??th). Iaioeaeiee eiiieaen ie?ie ?noioii ia aieeaaa ia
noai A-ee?oei (I-?OE oa CD22-iiceoeaieo ee?oei).

Caa?oa? ia naaa oaaao iacia/ia i?aeneeaiiy aeni?an?? HLA-DR, ui iiaea
aooe iiyniaii noaa?e?coth/ith ae??th iaioeae?a ia iaia?aii? iieaeoee
AEAN, ui a ?yae? aeiaaee?a ?icoaoiaai? ia iaia?ai? aac aioeaaiiiai
iaioeaea [ Schumacher T.N.M. et al., 1990], e??i oiai oe? aaoi?e
iieacaee iiaeeea?noue ca’yceo i?ae iaioeaeii oa «ii?iaeiueith»
iieaeoeith AEAN, ye in vivo, oae ? in vitro. E?euee?noue oaeeo
«ii?iaei?o» iieaeoe i?ae /an iaoieia?/ieo i?ioean?a ?noioii c?inoa?,
ieae/a ie ua coieieiinue ia oeueiio ieoaii?.

I?ae /an ae?? iaioeaeiiai eiiieaeno ie ia niinoa??aaee nainea?e?caoe??
e?ioioeeo?a ? nae?aoe?? oeeoie?i?a, caeaoieo aaeueioaaoe i?a?aoe?th
eaeeioeeo?a. Ia oii? iiia?aaeiueiai eiiaeeoe?thaaiiy ee?oei a
i?enooiino? iaioeaeiiai eiiieaeno ie?ie aaaaeaiiy i?oiaaio OAA a?eueo
?ioaineaii aaeueioaaei i?a?aoe?th, /ei o a?aenooiino? iaioeae?a. Ioaea
iaioeaeiee eiiieaen iiaeoethaaa a?aeiia?aeue e?ioioeeo?a ia OAA.

A?aeiii, ui i?ioeane aeeoa?aioe??iaee O-ee?oei a?aeaoaathoueny aieiaiei
/eiii a oeion?, aea aiane?aeie iiceoeaii? oa iaaaoeaii? naeaeoe??
a?aeae?athoueny iaiao?aei? eeiie O-ee?oei [ ss?eeei A.A., 1998;Hogquist
K.A. et al., 1994; Nossal G.J.V., 1994]. A oeeo i?ioeanao ia inoaiith
?ieue a?ae?a?athoue iieaeoee AEAN c? ca’ycaieie iaioeaeaie. Oiio aoei
oe?eaai aeine?aeeoe ye aieeaa? iaioeaeiee eiiieaen ie?ie ia
ii?oiooieoe?iiaeueiee noai oeiona i?ae /an ?ioiiiai a?aeaoea ia
oeioncaeaaeiee aioeaai (a?eo?ioeeoe aa?aia).

Iniiai? ci?ie eieae?coaaeeny a ei?oeeiiaaeoey?i?e cii?. I?ae aieeaii
iaioeaeiiai eiiieaeno a oeaiei? oeiona c’yaeyeeny iieiae? o?eueoey
Aanaey, niinoa??aaeenue eenoiiiae?ai? ooai?aiiy ca ?aooiie
ai?oae?aeueieo ee?oei. Oeeoic ei?eiai? ?a/iaeie ciaiooaaany. Oe? ci?ie
na?ae/aoue i?i aeoeaaoe?th ooieoe?iiaeueieo i?ioean?a a oeion? [
Aaeaoeeay E.A., Aiacaeeoeeay Y.A., Aaey?a Ae.E., 1986; Io/eia A.O. e
niaao., 1998], aeo?ae ee?oei ia ia?eoa??th. Ioaea ca o?c?ieia?/ieo oiia
iaioeaeiee eiiieaen ie?ie caeaoai aeoeaoaaoe ooieoe?iiaeuei? i?ioeane a
o?ion?, iiaeeeai ?iaeoeoaaoe aeo?ae e?ioioeeo?a o e?iaiia?a.

Aaaeeeaei ieoaiiyi aoei aecia/aiiy aioeaaiieo oa ?ioiiaaiieo
aeanoeainoae i?aia?aoo. Aaaaeaiiy i?aia?aoo oaa?eiai ia aeeeeeaei
?icaeoeo ?aaeoe?e a?ia?/ooeeaino? iaaaeiiai oeia, aaaaeaiiy ?acii c
iiaiei aae’thaaioii O?aeiaea oaeiae i?aeoe/ii ia aeeeeeaei
nainea?e?caoe??. A?eueo iii?oiith aoea caeaoi?noue iaioeaeiiai eiiieaeno
?iaeoeoaaoe neioac aiiioeeoio?iiieo aioeo?e. I?aia?ao i?aeoe/ii ia
aieeaaa ia aioeo?eiaaiac. Ioaea iaioeaeiee eiiieaen ie?ie aeyaeya neaae?
aioeaaii? aeanoeaino?.

Ni?anoaaeaiiy ?acoeueoao?a aeine?aeaeaiiy iieaciee?a aaiinoaco oa IIE a
na??yo in vitro oa i?ae /an aaaaeaiiy caei?iaei oaa?eiai aeiiiiiaei
aecia/eoe i?yi? oa ianiaoeeo?/i? ?ene ae??. Aei niaoeeo?/iiai aieeao
iaioeaeiiai eiiieaeno ie?ie ca iaoeie ?acoeueoaoaie iiaeii a?aeianoe
aeieoaaiiy o?iia?iiai? aeoeaiino?, oa i?enei?aiiy oaeaeeino?
o?a?eiie?co, iiaeeeai aiane?aeie aeoeaaoe?? ieaci?iiaaio. Oe?
aeanoeaino? iaioeaeiiai eiiieaeno ca?aathoueny c ooieoe?iiaeueieie
iniaeeainoyie ie?eiaiai e?iaioieo. Ae?y i?aia?aoo ia i?ioeane IIE iaea
iiina?aaeeiaaiee oa?aeoa?.

Ianooiiei e?ieii iaoeo aeine?aeaeaiue noaei aea/aiiy ae?? i?e?iaeiiai
iaioeaeiiai eiiieaeno ie?ie ca oiia ?icaeoeo iaoiaaiieo noai?a. A ia?o?e
/anoei? aeine?ae?a ian caoe?eaaea aieea i?aia?aoo i?ae /an oeiiaiai
iaoieia?/iiai i?ioeano, yeee aeeaa? ia noai ?ioiii? nenoaie (ia?aaaaeii
O-eaiee) oa nenoai, ui iaie aeaeine?aeaeoaaeenue, aea oaeee aieea ia
iiaeiai aooe iia’ycaiee ?c ?icaeoeii niaoeeo?/ieo ?ioiieo ?aaeoe?e.
Iaoieia??th, yea a?aeiia?aea? an?i oeei e??oa??yi, oa ia nueiaiaei?
aeineoue aeieeaaeii aea/aia, ? no?an [ Iaa?nii O.C.,1986; Iaeuoaa A.A.,
Aaneeueaaa A.N., Eocueiaiei A.A., 1997]. Iaea?eueo aaaeeeaith a
iaaee/iiio ieai? oi?iith no?ano ? aino?ee aiioe?eiee no?ann [Aaaeyaa
O.I., Ai?iaueaaa O.I.,1983]. No?ani?ia ?aaeoe?y noi?iaiaeaeo?oueny
ae?aaeaieie iaoaaie?/ieie ci?iaie oa i?eai?/aiiyi naia O-eaiee
?ioi?oaoo. Oea noi?iaiaeaeo?oueny cieaeaiiyi ai?noo O-ee?oei,
i?eai?/aiiyi ?o aeoeaiino? a oano? ?icaoeiooai?aiiy oa
aeanoo?ainoi?iaoe?? [No?eeia E.Ae., 1981].

sse iieacaee iao? aeine?aeaeaiiy, iaioeaeiee eiiieaen ie?ie aeeeeeaa
a?aeiiaeaiiy iieaciee?a ee?oeiiiai ?ioi?oaoo — ii?iae?caoe?y ai?noo O-
oa A-ee?oei, ?o caeaoiino? a?aeiia?aeaoe ia EiiA. Ii??aiyiiy ae??
iaioeaeiiai eiiieaeno c ae??th aioeieneaeaioiiai oa?iaioo
oea?oeiieaci?ia aeicaieeei aeyaeoe oa?aeoa?i? iciaee aieeao iaioeaeiiai
eiiieaeno: aeieoaaiiy o?iia?iiai? aeoeaiino?, aeoeaaoe?y o?a?eiie?co oa
ia?aaaaeiee i?aaiiniaoeeo?/iee aieea ia i?ioeane IIE oa aeoeai?noue
oa?iaioaoeaieo i?ioean?a a ie?eao.

Oeion ?acii c caeicaie aioo??oiuei? nae?aoe?? aa?a o/anoue a aaeaioaoe??
i?aai?cia aei ae?? oaeoi??a aeiae?eey [Iaa?nii O.C., 1986]. Aeoiaey/e c
oeueiai, aoei aeine?aeaeaii ae?th iaioeaeiiai eiiieaena a oiiaao
aino?iai AAN. Aaaaeaiiy iaioeaeiiai eiiieaeno aeeeeeaei ae?aaeaio
ii?iae?caoe?th i?ioean?a ?ioi?oaoo, ia?aaaaeii aoii?aeueiiai:
a?aeiiaethaaeanue eiioeaio?aoe?y eiiieaiaioo, ?ioiiaeiaoe?io G,
eiioeaio?aoe?y aooiaioeo?e aei oeaieie ie?ee oa oee?eoethth/? ?ioii?
eiiieaene.

A?aoiaoth/e cia/iee aieea iaioeaeiiai eiiieaeno ie?ie ia iieacieee
?ioi?oaoo, cie?aia, aeoeai?noue O-ee?oei oa ooieoe?iiaeueiee noai
oeiona, aoei oe?eaaei aeine?aeeoe eiai ae?th a oiiaao niaoeeo?/ii?
?ioiiiaoieia?? ie?ie. sse aenia?eiaioaeueio iiaeaeue aoei aeei?enoaii
iao?eo Oaeiaia, yeee iaeneiaeueii iaaeeaeaiee aei iaia?aiicii?
aeiia?oeiiao?? o ethaeae [Ae?aiiee A.I., 1989]. Aioeaaie,
a?aeiia?aeaeuei? ca ?icaeoie iao?eoo Oaeiaia, ?icoaoiaai? a eeoai/eia?e
aacaeuei?e iaia?ai?, u?oeia?e ea?ioe?. Aaeeeee ?ioa?an aeeeeea?
iayai?noue ia?ao?anii ?aaaoth/eo aioeaai?a a u?oeia?e ea?ioe?
eaiaeueoe?a ie?ie oa ei?eiai? ?a/iaeie oeiona ca aeaieie Bakker W.W. oa
ni?aaao. (1979). Iaoiaaiaoe/ia iniiaa iaoieia?? iieyaa? a a?aioey?ieo
a?aeeeaaeaiiyo ?ioiiaeiaoe?ia G i?ae ai?oae??i.

I?ae /an aaaaeaiiy iaioeaeiiai eiiieaeno ie?ie aoei ca?a?no?iaaii
?noioi? ci?ie iieaciee?a ?ioi?oaoo o oaa?ei c iao?eoii: c?inei /enei
e?ioioeeo?a a e?ia?, a?aeiiaeany cieaeaiee a?aenioie O-ee?oei,
eiao?oe??io O/A-ee?oeie c??n c 0,8 aei 1,3. Ciaioeany ?iaeaen
noeioeyoe?? e?ioioeeo?a EiiA oa ie?eiaei aioeaaiii aei ii?iaeueieo
iieaciee?a. Iaeii/anii ciaioeany oeo? ie?eiaeo aooiaioeo?e,
a?aeiiaeeanue eiioeaio?aoe?y Oe?E, ii?iae?coaaeanue ooieoe?iiaeueia
aeoeai?noue oaaioeeo?a.

Aaaaeaiiy iaioeaeiiai eiiieaeno ciaiooaaei e?euee?noue
O-ee?oei, ?io?eueo?oth/eo i?inoi?e iaae?oae noaeei oa eaiaeueoe?a, oa
ianya aeaiiceo?a ?ioiiaeiaoe?i?a aacaeueieo iaia?ai aeiia?oe. Iaeii/anii
c oeei ie niinoa??aaee a?aeiiaeaiiy acionae?aooth/i? ooieoe?? ie?ie.

?aaeoe?y oeiona caei?iaeo uo??a ia iaioeaeiee eiiieaen ie?ie iieyaaea a
i?aeaeuaii? i?oioe/ieo i?ioean?a a ei?eia?e ?a/iaei? c? c?inoaiiyi /enea
e?ioiaeano?a oa na?aaei?o e?ioioeeo?a c i?aeneeaiiyi aaaeoaoe?? iaeeo
e?ioioeeo?a c ei?eiai? aei iiceiai? ?a/iaeie ?, iiaeeeai, aeae? ca iaae?
i?aaio. Ca oiia iao?eoo oeiioeeoe caeeoaee oeion ia oe? cieaeaii?
i?oioe/ii? aeoeaiino? a ei?eia?e ?a/iaei? oa iecueei? eiioeaio?aoe??
iieiaeeo oi?i (e?ioiaeanoe, na?aaei? e?ioioeeoe), ui na?ae/eoue i?i
ooieoe?iiaeueia aeniaaeaiiy i?aaio [Oiaeueieoeeee I.E., Aaeyiei A.E.,
A?eioeaae/ E.E., 1983]. Canoinoaaiiy a oeeo oiiaao iaioeaeiiai eiiieaeno
a?aeiiaethaaei i?oioe/io aeoeai?noue oeiioeeo?a, e?euee?noue ?o iieiaeeo
oi?i ? iaa?oue ua a?eueoa i?aeneethaaei aeo?ae iaeeo e?ioioeeo?a.
I?aeaeuaiiy ?ici??o yaea? ?ao?eoei-ai?oae?aeueieo ee?oei aea? ciiao
ia?aaeaa/eoe ?o a?eueoo ooieoe?iiaeueio aeoeai?noue i?ae ae??th
iaioeaeiiai eiiieaeno.

Ioaea, i?ae /an ?icaeoeo aooi?ioiiiai a?aeaoea ia ie?eia? aioeaaie
(iao?eo Oaeiaia) iaioeaeiee eiiieaen ie?ie cieaeoaaa i?iyae aooi?ioiii?
a?aeiia?ae?, ni?yiiaaii? ia aioeaaie ie?ee.

Oae? ci?ie ia iiaeia iiynieoe ?ioiiaeai?aneaiei aieeaii
iaioeaeiiai eiiieaeno ie?ie. Aeine?aeaeaiiy i?iaaaeai? in vitro oa ia
caei?iaeo oaa?eiao, ? oeo ui i?aeeyaaee no?ano, ia aeyaeee
?ioiiaeai?aneaii? ae?? i?aia?aoo. Ioaea, ca oiia aooi?ioiiiai iao?eoo
iaioeaeiee eiiieaen aeieoaaa ?icaeoie aooi?ioiii? a?aeiia?ae? ia
aioeaaie ie?eiai? oeaieie, iiaeeeai oeyoii a?aeiiaeaiiy ?ioiieia?/ii?
oiea?aioiino?.

?ioiieia?/ia oiea?aioi?noue oa i?ioeane, ye? ?? i?aeo?eiothoue iathoue
??ci? ??ai? [ Ferber I. et al.,1994; Arnild B., Schonrich G., Hammerling
G.J., 1993 ], oeaio?aeueiee — oeion, oa aeae?eueea ia?eoa??eieo.
?iaioaie oeeo aaoi??a iieacaii, ui c??e? O-ee?oeie, ye? caeeoathoue
oeion, caeeoathoueny /ooeeaeie aei ?iaeoeoe?? oiea?aioiino?. Nooi?iue
oiea?aioiino? i?e oeueiio aecia/a?oueny: 1) ao?ii?noth O-ee?oeiiiai
?aoeaioi?a, ??aiai aeni?an?? O-ee?oeiiiai ?aoeaioi?a oa aeiiii?aei?o
iieaeoe; 2) noaae??th ?icaeoeo O-ee?oei. O-ee?oeie, uieii ai?a?oaaao? c
oeiona, a?eueo caeaoi? aei ?iaeoeoe?? oiea?aioiino?, /ei aei aeoeaaoe??
(!). Ioaea ?aiiy aeni?an?y aioeaaia aaaea aei oiea?aioiino?, a i?ciy —
aei aooi?ioi?caoe??. Eiioaeo i?ae O-ee?oeiiei ?aoeaioi?ii oa iieaeoeie
AEAN c? ca’ycaiei iaioeaeii iiaea a?aeaoaaoeny o?aaeeoe?eii, eiee i?a?o?
e?ioioeeo, ? aeueoa?iaoeaii — eiee i?a?o? eiiieaen AEAN-iaioeae,
?icoaoiaaiee ia iaia?ai? AIE. A oie aea /an, O-ee?oeiiee ?aoeaioi? iiaea
aca?iiae?yoe ?c ?ic/eiaiei a?eueiei iaioeaeiei aioeaaiii, yeee
niaoe?aeueiei ia?acii ia?iaeaiee: ia? iecueeo iieaeoey?io iano oa
o?aaiaio aeey ca’ycoaaiiy c ?aoeaioi?ii .

Ioaea, a?aoiaoth/e ciaeaeai? ci?ie a oeion? oa ia ia??oa??/ieo
CD8-iiceoeaieo O-ee?oeiao (ciaioaiiy nooiaiy oethi?anoeaioe?? oa
eeanoa??caoe??), iiaeia aaaaeaoe, ui iaioeaeiee eiiieaen ia?
aeaiiai?aaeaio ae?th, ye ia oeaio?aeueiee, oae ? ia ia?eoa??eiee ??ai?
oiea?aioiino?.

Aeey oiai uia aiaaieoenue o niaoeeo?/iino? oiea?iaaiii? ae?? iaioeaeiiai
eiiieaeno ie?ie ie a?aeoai?eee iiaeaeue iie?eiiiiiaioii? ?ioiiiaoieia??
— iaeii/ania ?ioi?caoe?y ie?eiaei aioeaaiii ? a?eeaie ne?iaaoee e?ia?.

Io?eiai? ?acoeueoaoe aeiaiaeyoue, ui ca oeeo oiia iaioeaeiee eiiieaen
aoa caeaoiee onoaaoe yaeua nainea?e?caoe?? e?ioioeeo?a aei aooiaioeaai?a
ie?ie, aea ia aeeeth/aa aooi?ioiii? ?aaeoe?? aei a?ee?a ne?iaaoee, oiaoi
iaioeaeiee eiiieaen aeeacoaaa niaoeeo?/io oiea?iaaiio ae?th. Ne?ae
caoaaaeeoe, ui i?e oe?e iaoieia?? oa?aiaaoe/ia aeoeai?noue iaioeaeiiai
eiiieaeno aoea iaio ae?aaeaia, /ei i?e ?cieueiaaiiio iao?eo?.

A ?iaioao B.Arnold oa ni?aaao. (1993-1994)
aeaiiino?o?oueny, ui ia?eoa??eia oiea?aioi?noue a?eueo iayaii
aeyaey?oueny i?ae /an o?ainieaioaoe?eieo aenia?eiaio?a. E??i oiai,
o?ainieaioaoe?y ie?ee a oiiaao aooi?ioiieo caoai?thaaiue ie?ee oa ??
?ioiiee caoeno i?ney o?ainieaioaoe?? iathoue cia/io aaaeeea?noue oa
i?aeoe/io oe?ii?noue [Ae?aiiee A.I., 1971, 1980; Barbara A. et al.,
1997]. sse i?iaeaiiino?oaaee iao? aeine?aeaeaiiy aaaaeaiiy iaioeaeiiai
eiiieaeno ie?ie a cia/iiio nooiaith a?aeaa?oaei ?icaeoie ?aaeoe??
a?aeoi?aiaiiy (ciaioaiiy e?ioi?aeii? ?io?eueo?aoe?? o?ainieaioaoo) oa
iao?eoo a eiio?eaoa?aeuei?e ie?oe?. A oe?e na??? aeine?ae?a ie oaeiae
niinoa??aaee yaeua aeieoaaiiy a?aeiia?ae? e?ioioeeo?a iaioeaeiei
eiiieaenii ia aioeaaie ie?ie, aea ia ia i?oiaai.

I?ae /an aianaiiy o e?ia oai?eo ia o?ii?/iee aeiia?oeiiao?eo iaioeaeiee
eiiieaen a?aeiiaethaaa a?aenioie A-?OE oa O-oaeia??a, cieaeoaaa
a?aeiia?aeii aei ii?iaeueieo cia/aiue I-?OE oa aeoeai?noue oaaioeeoico,
ii?iae?coaaa aaeaac?eio caeaoi?noue iaeo?io?e?a (A-?OI) oa iieacieee
?AOE ia EiiA.

A i?iia?nuee?e ?iaio? Sloan-Lancaster J. oa ni?aaao. (1993) aeiaaaeaii,
ui ci?iai? e?aaiaee O-ee?oeiieo ?aoeaioi??a ia aeeaeo AIE iiaeooue
?iaeoeoaaoe O-ee?oeiio aia?a?th aai a?ia?a?a?th. Oiio ie ae??oeee
aeine?aeeoe /e ci?ith?oueny niaeo? i?e?iaeieo iaioeaeieo ?a/iaei ie?ee
i?ae /an ?icaeoeo iaoieia?/ieo i?ioean?a, cie?aia i?e iao?eo? Oaeiaia.
Aoei ciaeaeaii, ui a?aeoai?aiiy iaoieia?? oa?aeoa?eco?oueny cieeiaiiyi
ie?aieo o?aeoe?e oa iiyaith ?ioeo, iiaeo, i?e/iio a?aeiinia ieoiia aaaa
cia/ii ci?iaia. Aaaaeaiiy aeciaaiiiai iaioeaeiiai eiiieaeno aeeeeeaei
a?aeiiaeaiiy i?e?a ??cii? i??e.

Oaeei /eiii, ca oiia iaoieia?? ci?ith?oueny niaeo? iaioeae?a AEAN, ui
oe?eeii c?i?coi?ei, oiio ui iieaeoee AEAN i?acaioothoue o?aaiaioe a?ee?a
ci?iaieo aai ?ai?o ia neioaciaaieo, a?aeia?aaeathoue ianya neioaco
a?ee?a aioo?? ee?oeie.

Ioaea, ca aeiiiiiaith oaeeo iaioeaeieo o?aaiaio?a ee?oeia caeaoia
?ioi?ioaaoe iaaeieeoi? ioi/aiiy i?i na?e ooieoe?iiaeueiee noai.

sse iieacaee iao? aeine?aeaeaiiy, iaioeaeiee eiiieaen ie?ie yaey?
neeaaeio aaaaoieiiiiiaioio ?a/iaeio. Oiio iinoaei ieoaiiy, /e iaeiaeiaa
ae?y ??cieo o?aeoe?e ia i?ioeane i?ie?oa?aoe?? e?ioioeeo?a. Aoei
ciaeaeaii, ui ie?ai? o?iiaoia?ao?/i? o?aeoe?? iaioeaeiiai eiiieaeno
ie?ie caeaoi? aieeaaoe ia i?ie?oa?aoe?th ieoeieo nieaiioeeo?a oa ee?oei
e?i?? CTLL. Ioaea a ia?aio?i? ie?ie i?noyoueny iaioeaei? ?a/iaeie
caeaoi? a o?c?ieia?/ieo oiiaao ianiaoeeo?/ii ?aaoethaaoe aeoeai?noue
e?ioioeeo?a, a i?e iaoieia?? aenooiathoue aaea ye niaoeeo?/i?
ianaiaeaea?e. Iiaeeea?noue ?nioaaiiy oaeiai i?ioeano i?aee??ieth?oueny
oaeiae aeaieie i?i ci?io ni?aa?aeiioaiiy ie?aieo o?aeoe?e iaioeaeiiai
eiiieaeno i?e ?icaeoeo aooi?ioiii? iaoieia?? ie?ie.

Caa?oa? ia naaa oaaao a?aei?ii?noue ae?? iaeieo ? oeo iaioeaeieo
o?aeoe?e ia e?ioioeeoe, aeoeaiaai? i?oiaaiii EiiA oa aiaeiaaiiei
?inoiaei oaeoi?ii — ?E-2. Eiia??ii a?aei?ii?noue iieyaa? o aieea?
iaioeae?a ia oa?aeoa?i? aeoeaaoe?ei? aoaie O-ee?oei [Aa?aaeiay I.I.,
Ai?aoeeee A.A., 1992; Paul W.E. et al., 1984]. A??ia?aeii ioieo ae??
io?eiaieo iaioeae?a ne?ae ooeaoe a eaneaae? ?aaeoe?e, ye?
niinoa??aathoueny ne?ae ca ae??th ?E-2, oiaoi e?aaiae-?aoeaioi?ia
aca?iiae?y ?inoiaeo oaeoi??a, neioac ee?oeiieo i?ioiiieiaai?a ?
?aoeei?ieia ?iaeoeoaaiiy neioaco noaiaeeieoeue ?aoeaioi?a ?E-2.

Oaeei /eiii, ie?ai? iaioeaei? o?aeoe?? ei?eiai? ?a/iaeie ie?ee caeaoi?
ianiaoeeo?/ii ae?yoe ia i?ie?oa?aoe?th iai?ei??iaaieo e?ioioeeo?a,
?iaeoeiaaio EiiA oa ?E-2. Iaea?eueo /?oea ae?y niinoa??aa?oueny i?e
aeoeaaoe?? ?E-2. Iiaeeeai io?eiai? iaioeaee ae?thoue ia nenoaie, ye?
?aaoeththoue ?ino oa i?ie?oa?aoe?th ee?oei, iia’ycai? c ae??th ?inoiaeo
oaeoi??a oa ee?oeiieo i?ioiiieiaai?a, cae?enithth/e ca o?c?ieia?/ieo
oiia eiiia?aoe?th i?ae ?ioiioeeoaie oa ee?oeiaie iao?iio, oa
?aae?cothoue i?ioeane ?aia?aoe?? oa eiiiainaoe??.

Aeoiaey/e c oiai, ui aeine?aeaeoaaiee iaioeaeiee eiiieaen ie?ie
i?iaeaiiano?oaaa iayai?noue niaoeeo?/ieo oa ianiaoeeo?/ieo aoaeo?a,
iinoaei ieoaiiy /e a?ae??ciythoueny iaioeaei? ?a/iaeie aeno?aaiaai? c
ie?ie a?ae iaioeae?a io?eiaieo c ?ioeo i?aai?a, oa /e iiaeia aeae?eeoe
i?aaiiniaoeeo?/i? oa ianiaoeeo?/i? o?aeoe?? a ?o neeaae?.

I?iaaaeai? aeine?aeaeaiiy aeaee ciiao na?oioaaoe iaioeaei? eiiieaene ca
o?iiaoia?ao?/ieie oa?aeoa?enoeeaie oaeei /eiii: a?oia ia?aio?iaoicieo
i?aai?a — naeac?iea, ia/?iea, ie?ee; aiaeie?eii? caeice — i?aeoeoieiaa
caeica, o?ion; ie?aii — ia?iaeiio.

Oea iiaea aooe iia’ycaii ?c niaoeeo?/iei aeey eiaeiiai i?aaio /e oeaieie
aoaiaie i?ioaie?oe/iiai i?ioean?iao a?eeiaeo no?oeoo?, eio?ee ia? i?noea
aai i?e aeaa?aaeaoe??, aai i?e iinoo?aineyoe?eii? iiaeeo?eaoe?? ciia
neioaciaaieo a?ee?a. Oe?eaai, ui o?e ciaeaeai? o?aaiaioe aaiiaeia?io a
yeino? N-e?ioeaai? ai?iieeneioe iathoue caeeoie e?c?io. Oea iiaea
na?ae/eoe ca oa, ui oe? o?aaiaioe iiaeooue aooe ooai?ai? aiane?aeie
iaiaaeaiiai i?ioaie?co iieaeoe aaiiaeia?io, oiio ui a?aeiii, ui
?icuaieaiiy iieaeoe-iiia?aaeiee?a aieiaiei /eiii a?aeaoaa?oueny a ?aeii?
eieae?caoe?? eoaeieo ai?iieeneio — a?a?i?ia oa e?c?ia. A??ia?aeii, oae?
aeanoea? eiaeiiio i?aaio aai oeaiei? iaioeaei? iieaeoee aa?ooue o/anoue
ye o i?aeee?oeiiiio neaiae?coaaii?, oae ? i?ae o?c?ieia?/ii iia’ycaieie
i?aaiaie oa nenoaiaie.

Ca?aei?noue o?iiaoia?ao?/ieo oa?aeoa?enoee iaioeaeieo eiiieaen?a,
aeno?aaiaaieo c a?oie ia?aio?iaoicieo i?aai?a , iinoaaeea ieoaiiy i?i
niaoeeo?/i?noue ae?? iaioeaeiiai eiiieaena ie?ie.

Aeey c’ynoaaiiy oeueiai ieoaiiy aoea i?iaaaeaia na??y aeine?aeaeaiue
aieeao iaioeaeiiai eiiieaeno ia/?iee ia aeaye? iieacieee ?ioi?oaoo,
aaiinoaco oa ianiaoeeo?/ii? ?acenoaioiino? i?aai?cio a oiiaao ii?ie oa
i?e ?icaeoeo aooi?ioiiiai iao?eoo.

sse iieacaee aeine?aeaeaiiy, iaioeaeiee eiiieaen ia/?iee i?aeaeuoaaa
??aaiue Aa-?OE. Aea/aiiy aieeao i?aia?aoo ia noai oaaioeeoa?ieo ?aaeoe?e
aeyaeei eiai aeicicaeaaeio aeoeaoth/o ae?th ca iieacieeaie INO-oanoo oa
oaaioeeoa?iiai ?iaeaeno oa aeieoth/o ia aeoeai?noue e?ciniiaeueieo
eaoeiiieo a?ee?a. I?e aianaii? o aeiii?nueeo e?ia iaioeaeiee eiiieaen
ia/?iee aaeueioaaa i?ioeane cn?aeaiiy e?ia? oa o?a?eiie?co, nooo?ai ia
aieeaaa ia iieaciee o?iia?iiaiai /ano.

Ca oiia ?icaeoeo iao?eoo Oaeiaia iaioeaeiee eiiieaen ia/?iee ia aieeaaa
ia aooi?ioiio a?aeiia?aeue ia oeaieii? aioeaaie ie?ie.

Iiia?aaei?ie aeine?aeaie ie iieacaee, ui iaioeaeiee eiiieaen ie?ie
aieeaaa ia i?ioeane ?aaaia?aoe?? a ie?eao ? ca ieceith iieaciee?a
aeyaeya i?aaiiniaoeeo?/i? iciaee ae??. Oiio ie ii??aiyee ae?th
iaioeaeieo eiiieaen?a ie?ie oa ia/?iee ia iaeiie/aiiy 3I-o?i?ae?io a
i?aaii?e eoeueoo?? ie?ee, ui a?aeia?aaeo? i?ioeane a?ineioaca AeIE.

I?ae /an i?iaaaeaiiy aeine?aeaeaiiy ie c’ynoaaee, ui eeoa iaioeaeiee
eiiieaen ie?ie a??ia?aeii i?aeneethaaa iaeiie/aiiy 3I-o?i?ae?io, oea ua
?ac i?iaeaiiino?oaaei i?aaiiniaoeeo?/i?noue aieeao.

Oaeei /eiii, aiane?aeie i?iaaaeaieo aeine?aeaeaiue iiaeeeai aeae?eeoe
niaoeeo?/i? oa ianiaoeeo?/i? ?ene ae?? iaioeaeiiai eiiieaeno ie?ie. Aei
niaoeeo?/ieo aoaeo?a ne?ae a?aeianoe: aieea ia aioeaainiaoeeo?/io
a?aeiia?aeue ia ie?eia? aioeaaie, caeaoi?noue aieeaaoe ia i?ioeane IIE
oa a?ineioac AeIE a ie?eia?e oeaiei?, aaeueioaaiiy o?iia?iiai?
aeoeaiino? oa o?a?eiie?co. Aei ianiaoeeo?/ieo aoaeo?a ne?ae a?aeianoe:
aieea ia ai?no O-aeoeaieo ee?oei oa aeoeai?noue oaaioeeoico, caeaoi?noue
aieeaaoe ia i?ioeane IIE a e?ia?.

Iaeiei c eeth/iaeo aniaeo?a ?icoi?iiy iaoai?cio ae?? iaioeae?a,
aeno?aaiaaieo c oeaiei, ? i?ioean o?ainaeoeoe?? iaioeaeiiai neaiaeo.
Acaaae?, i?iaeaia iieyaa? a iioooe? iaia?aiieo no?oeoo?, eio?? caeaoi?
ca’ycoaaoe iaioeaei?/iie?iaioeaei? iieaeoee. sse i?eaaaeaii a
e?oa?aoo?iiio iaeyae?, ia ?ieue iaioeaeca’ycoth/eo iieaeoe iiaeooue
i?aoaiaeoaaoe: ?ioiiaeiaoe?ie, iieaeoee AEAN, iieaeoey?i? oaia?iie oa
niaoeeo?/i? ?aoeaioi?e. Iaoo oaaao i?eaa?ioea a?oia iieaeoey?ieo
oaia?ii?a, ii-ia?oa, ?o aeineoue oe?ieith niaoeeo?/i?noth ca’ycoaaiiy,
ii-ae?oaa, ?o ia c?icoi?eith i?enooi?noth ia ciai?oiueiee?oeiieo
iaia?aiao [DeNagel D.C., Pierce S.K.,1993].

Io?eiai? iaie ?acoeueoaoe aeaiiino?othoue, ui iieaeoee iieaeoey?ieo
oaia?ii?a Hsp70, ca?eueiai? a?ae aiaeiaaiiica’ycaieo iaioeae?a, caeaoi?
aca?iiae?yoe c ie?aieie o?aeoe?yie iaioeaeiiai eiiieaeno ie?ie.
A?aoiaoth/e, ui a aeine?aeaeaii? ie aeei?enoiaoaaee i?aia?aoe Hsp70 ia
o?eueee iaia?aiiiai ioea, aea ? a cia/i?e i??? aioo??ee?oeii?, c
a??ia?aei?noth iiaeia noaa?aeaeoaaoe eeoa i?i oaeo aca?iiae?? i?ae
iieaeoey?ieie oaia?iiaie Hsp70 oa eiiiiiaioaie iaioeaeiiai eiiieaeno.
Oea aea? i?aenoaao ia?aaeaa/aoe, ui iieaeoey?i? oaia?iie Hsp70 iiaeooue
a?aoe o/anoue a ?aae?caoe?? iaioeaeiiai neaiaea.

Caaaeueiiaeciaiei i?aeoiaeii aei aea/aiiy a?ieia?/ii? aeoeaiino?
iaioeaeieo noi?oae ? iiaoaiia aeine?aeaeaiiy oe?e?nii? noi?o? c
ianooiiei aea/aiiyi ie?aieo o?aeoe?e. Aiane?aeie aeeiiaiiy oe???
i?ia?aie aeine?aeaeaiue io?eiaiee ?acoeueoao aea? ciiao aeae?eeoe
aeae?eueea iaioeae?a c aecia/aiith a?ieia?/iith aeoeai?noth, ye i?aaeei
i?e oeueiio ao?a/athoueny aeanoeaino?, ui aoee i?eoaiaii? oe?e?ni?e
noi?o? [Aieei N.N. e niaao.,1998; Aiiaceia I.A., 1995].

Iaie aoa aea?aiee ?ioee i?aeo?ae, cai?iiiiiaaiee K.Falk oa O.Rotzschke
(1991) aeey aea/aiiy iaioeae?a ca’ycaieo iieaeoeie AEAN a eeoai?
Aei?eiaia. Ei?ioei nooue iieyaa? a aeno?aeoe?? eiiieaena iaioeae?a,
o?iiaoia?ao?/iiio aiae?c? ? aea/aiith ocaiaeaeaii? iine?aeiaiino? ioea
iaioeaeieo o?aeoe?e.

Aeeiiaiee aiae?c iieacaa — caeeoeaie, ui aeii?iothoue, ? aae?i,
ania?aa?iiaa oa aeooai?iiaa eeneioe a iiceoe?? 2, e?c?i- a 3,
ania?aa?iiaa eeneioa — a 4, ? a?a?i?i — a 6 iiceoe??. E??i oiai,
caneoaiao? iaaiai?aiiy ia?aaaaeia ?icoaooaaiiy i?ie?ia a 2 oa 3
iiceoe?yo. Iiae?ai? ?acoeueoaoe aoee io?eiai? oaeiae a ?iaio?
[Falk K., Rotzschke O.,1994] ? ?icoe?iai? ye iane?aeie i?ioean?iao
iaioeae?a, yeee ia aieeaa? ia ca’ycoaaiiy c iieaeoeaie AEAN.

Aeoiaey/e c aiae?ca ai?iieeneioii? iine?aeiaiino? ioea iaioeae?a iaie
aoea neeaaeaia iiooeiaa oi?ioea aeey c’ynoaaiiy i?eionea?ii?
iine?aeiaiino? a neeaae? a?aeiieo a?ee?a. Oae? iine?aeiaiino? aoee
ciaeaeai? a neeaae? aeii?oace (oa?iaio oeeeea E?aana), eio?e?io oa
aeano??io (aeo?i-ca’ycoth/? a?eee), iiia?aaeiee?a ooii?iae?ioe/iiai
oaeoi?o aeueoa, aano?eio oa ?aeaeneio, a oaeiae ni?a?io (i?aeneeth?
aniieooaaiiy aiaee oa iao??y).

Iayai?noue o?aaiaio?a oeeo a?ee?a aeoaea aaaeeeaa, oiio ui iayai?noue
aeo?io, ??aaiue iao??y, ? aaaeeeaeie oaeoi?aie ?aaaia?aoe?? iao?iio
[Rosenberg M.E., Paller M.S.,1991].

Aiane?aeie iiooeo oa aiae?co iine?aeiaiinoae ?aaeueieo iaioeae?a aoei
neeaaeaii oi?ioeo aeey neioaca iaioeae?a-aiaeia?a: a ia?o?e iiceoe??
ciaoiaeeoueny ethaa ai?iieeneioa (iiaeeeai i?ie?i aeey caoenoo ai?oiia),
a 2 iiceoe?? — aeooai?iiaa aai ania?aa?iiaa eeneioe, a 3 — e?c?i, a 4 —
ania?aa?iiaa eeneioa aai a?no?ae?i, a 5 — ethaa, a 6 — a?a?i?i, a 7 —
ethaa ai?iieeneioa. A yeino? ethaie eeneioe /ano?o aeei?enoiaothoue
iaiiey?i? iaca?yaeaeai? ai?iieeneioe.

Ioaea, oyaeyeinue ?aaeueiei neioacoaaoe ?aaeueio iaioeaeio noanoaioe?th
ia a?oio? ciaeaeaii? oi?ioee, yea a aieiae?ea ?ioiii?ioaeoi?ieie
aeanoeainoyieo ca oiia ?ioiiiaoieia?? ie?ie. Aoee neioaciaai? oaee
iaioeaee: i?i-aeo-e?c-ani-eae-a?a-e?c (PEKDLRK),
i?i-aeo-e?c-ani-na?-a?a-e?c (PEKDSRK), i?i-aeo-e?cani-ani-a?a-eae
(PEKDDRL). A?ieia?/ia aeoeai?noue iaioeae?a-aiaeia?a aeine?aeaeoaaeanue
iaie ia iiaeae? aooi?ioiiiai iao?eoo Oaeiaia oa ii??aithaaeanue c
aeoeai?noth i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie.

Aea/aiiy iieaciee?a ?ioi?oaoo, IIE oa AIO, ii?oiooieoe?iiaeueiiai noaio
ie?ie oa oeiona aeiaaei, ui iaea?eueo aeoeaiei neioaoe/iei iaioeaeii aoa
PEKDLRK, aoaeoe yeiai iaaeeaeaeeny aei i?e?iaeiiai iaioeaeiiai eiiieaena
ie?ie ? a ?yae? aeiaaee?a ia?aaa?ooaaee eiai.

Iaie aoei aeine?aeaeaii aieea neioaciaaieo iaioeae?a aiaeia?a ia aeaye?
?ioiieia?/i? iieacieee i?ae /an aaaaeaiiy o e?ia caei?iaeo aeiii??a. An?
iaioeaee iaee caeaoi?noue cieaeoaaoe a?aenioie O-noi?ani?? ?
a?aeiia?aeii i?aeaeuoaaoe — O-oaeia??a, iaea?eueo aeoeaiei aeyaeany
iaioeae PEKDSRK. Iaioeaee ?noioii ia aieeaaee ia ai?no O- ? A-ee?oei.

Neioaoe/i? aiaeiae aeoeaoaaee i?ioeane oaaioeeoica oa eenaiueaeoeaoth/o
oa i?ioaie?oe/io ooieoe?th iaeo?io?e?a, i?e/iio PEKDLRK iaea?eueo
i?aeneethaaa eenaiueaeoeaoth/o ooieoe?th iaeo?io?e?a, a PEKDSRK
iaea?eueo ?noioii i?aeneethaaa i?ioaie?oe/io aeoeai?noue.

Oe? aeai? aeia?a ocaiaeaeothoueny c iauiaeaaii i?iaeaiiino?iaaieie
a?aeiiinoyie, ui iaioeaee, ye? iiaeaeththoue ai?oii O-ee?oeiiiai
?ici?ciaaaiiy, caeaoi? a?aeaa?oaoe ?icaeoie aooi?ioiieo caoai?thaaiue
[DeMagistris M.T. et al., 1992]. Iio?i neioaoe/iee iaioeae,
a?aeiia?aeath/ee ?ioiiaeii?iaioiiio ai?oiio a??ona e?ioioeeoa?iiai
oi??iiai?ia?oo aoa aeei?enoaiee aeey i?ei??oaaiiy oa a?aeiiaeaiiy
?ioiieia?/ii? oiea?aioiino? in vivo o o?ainaaiieo ieoae, o eio?eo ai?oii
a??ona aeni?anoaaany o i?aeoeoieia?e caeic?, a?aeaa?oath/e iioeiaeaeaiiy
aaoa-ee?oei ? ?icaeoie ae?aaaoo o oaeeo ieoae [Iaeuaeaa A.A.,1998;
Aichele P. et al.,1994].

I?ae /an aianaiiy neioaoe/ieo iaioeae?a o e?ia aeiii??a io?eiai?
iaioeaee i?aeaeuoaaee a?aenioie oaio?e?i-?acenoaioieo ee?oei
(O-oaeia??a), cieaeothoue — oaio?e?i/ooeeaeo, aeoeaothoue oaaioeeoa?i?
ooieoe??.

Oaeei /eiii, io?eiai? iaie neioaoe/i? iaioeaee, ye? iiaeaeththoue
i?e?iaeiee iaioeaeiee eiiieaen ie?ie aoee caeaoi? aeieoaaoe ?icaeoie
aooi?ioiiiai iao?eoo ? aeyaeyee ?ene iioaioe?eieo oa?iaeieia?/ieo
?a/iaei.

Nueiaiaei? aaea a?aeii? e?ea?nuee? ?a/iaeie, ye? yaeythoue niaith
neioaoe/i? iaioeaee, ui iiaeaeththoue no?oeoo?o O-ee?oeiiiai ai?oiio.
Eeane/iei i?eeeaaeii ? eiiie?ia? 1, ae?th yeiai iiaeia iienaoe oaeei
aeine?aeii. O uo??a ?iaeoeoaaee ?icaeoie aea?a?/iiai aioeaoaeii??e?oo
oeyoii aaaaeaiiy nieiiiai iiceo aai neioaoe/ieo iaioeae?a
i?ioaie?i?aeiiai a?eeo ?139-151 oa 178-191. Eiiie?ia? 1 a?aeaa?oaa
?icaeoie caoai?thaaiiy, aeieoaaa aioeaainiaoeeo?/io a?aeiia?aeue
niaoeeo?/ieo O-ee?oeiieo e?i?e, aea ia aieeaaa ia iie?eeiiaeueio
a?aeiia?aeue, aeeeeeaio noia?aioeaaiii (aioa?ioienei A). Eiiie?ia? 1
caiia?aaa ca’ycoaaiith ?139-151 oa ?178-191 c iieaeoeaie IIN oa ,a?eueo
oiai, iia aeooiaooaaoe oe? iaioeaee ?c ca’ycoth/iai naeoa IIN
[Teitelbaum D. et al.,1996].

Oaeee aeieoth/ee aieea ia aioeaainiaoeeo?/io a?aeiia?aeue aac
?ia?a??oaaiiy iie?eeiiaeueii? a?aeiia?ae? ie niinoa??aaee i?aeoe/ii a
on?o iao?o aeine?aeao c iaioeaeiei eiiieaenii ie?ie i?e ?ioii?e
iaoieia??.

Nueiaiaei? eiiie?ia? 1 aaea oni?oii aeei?enoiao?oueny a ee?i?/i?e
i?aeoeoe? aeey e?eoaaiiy ?icn?yiiai neea?ico naiino?eii aai a
eiia?iaoe?? c aiaeiaaiieie ?ioiiiiaeoeyoi?aie [Milo R., Panitch H.,
1995].

sse a?aeiii, ?ioiia nenoaia ia? i?oei? ooieoe?iiaeuei? ca’ycee c ?ioeie
nenoaiaie ?acenoaioiino? e?ia? — eiaaoeyoe?eiith oa ia?aeeniei
ieeneaiiyi e?i?ae?a ?acii ?c aioeieneaeaioiei caoenoii [Eociee A.E. e
niaao., 1989; Ieuaiei A.I. e niaao., 1982-1995; Ae?aiiee A.I., 1989],
oiio ie oaeiae aeine?aeeee ? oe? i?ioeane.

Aianaiiy iaioeaeiiai eiiieaeno o e?ia aeiii??a, aaaaeaiiy caei?iaei
oaa?eiai ? oaa?eiai c aenia?eiaioaeueiith iaoieia??th aeyaeei oae?
iniiai? ?ene ae?? — aeieoaaiiy ciai?oiueiai oeyoo cn?aeaiiy e?ia?,
aeieoaaiiy o?iia?iiai? aeoeaiino? oa aeoeaaoe?y o?a?eiie?co. Oe?
aeanoeaino? iaioeaeiiai eiiieaeno aeoaea aaaeeea? c oi/ee ci?o
ooieoe?iiaeueiiai eieaeueiiai aaiinoaco [Kanfer A., 1984-1990].

??aaiue IIE oa AIO a?aeia?aaeothoue ooieoe?iiaeueio aeoeai?noue oa
ii?oieia?/io oe?e?ni?noue ee?oei ie?ie aoe?eiio [?iaiaie TH.A., Aiaeaiei
A.E., 1989; Iwasaki K.,1990; Dagget D.A. et al., 1997; Paller
M.S.,1988].

A on?o na??yo aeine?ae?a, aea aea/aee iieacieee IIE oa AIO, aoee
ciaeaeai? nooo?a? ci?ie o oai?eo oaa?ei. Aaaaeaiiy iaioeaeiiai eiiieaeno
ie?ie a?aeiiaethaaei oe? iieacieee aei ??aiy caei?iaeo oaa?ei. Oe? ci?ie
ie iia’yco?ii c ae??th iaioeaeiiai eiiieaeno ia ooieoe?iiaeueiee noai
ee?oei, yea iai?yii a?aeia?aaeo?oueny ia iieacieeao IIE oa AIO.

Ianooiia ieoaiiy, yea ia iao iiaeyae iio?aao? iaaiai?aiiy, oea oa ui i?e
aeineoue iao?eaaeiio oa?i?i? aaaaeaiiy iaioeaeiiai eiiieaeno ie?ie ie
niinoa??aaee /?oeee oa?aiaaoe/iee aieea oa, a aaaaoueio aeiaaeeao,
ii?iae?caoe?th noaio ii?oieia?/ieo no?oeoo? ie?ee.

Oey i?iaeaia iinoaea i?ney aiae?co e?oa?aoo?e, i?enay/aii? ee?i?/i?e
oa?ai?? ?icn?yiiai neea?ico eiiie?ia?ii 1 , aea iaaaaeaii aeai? uiaei
aeinyaiaiiy ee?i?/iiai iie?auaiiy i?e o?eaaeiio canoinoaaii? i?aia?aoo.

Ia iao iiaeyae, oea iiaea aooe iia’ycaii c aeaiia i?e/eiaie. Ii-ia?oa,
aoaeo i?ney aaaaeaiiy iaioeae?a a aenia?eiaioaeueieo oiiaao
a?aeaoaa?oueny oaeae/a, aiane?aeie oiai, ui aenia?eiaioaeueia iaoieia?y
/?oei aecia/aia, ye i?aaeei iiiiao?ieia?/ia, c a?aeiiei iaoiaaiacii. Oie
aea eiiie?ia? i?e aenia?eiaioaeueiiio aioeaoae?o? ae?ya iaaaaaoi
oaeae/a, /ei ca ee?i?/ieo oiia [Teitelbaum D. et al., 1996]. I/aaeaeii,
ui no?iee ee?i?/iiai canoinoaaiiy aeine?aeaeoaaieo iaie ?a/iaei aoaeooue
a?eueo o?eaae?. Ii-ae?oaa, ia?aiaa oa ie?eiaa oeaieie iathoue ??ci?
no?iee ?icaeoeo eiiiainaoe?eieo oa aaeaioaoe?eieo ?aaeoe?e, ??ci? oi?ie
?aaaia?aoe??. Aeey ie?ie oe? i?ioeane a?aeaoaathoueny a?eueo aeeiai?/ii.

A ie?eao i?ney ae?? iioeiaeaeoth/eo oaeoi??a i?enoinoaaeuei? oeoeooaoe??
ooieoe?iiaeueii? aeoeaiino? oa ii?iae?caoe?y ii?ooaieo ooieoe?e
caaacia/o?oueny a ??ai?e i??? ca ?aooiie a?ia?ieac?? ee?oei oa
aioo??ee?oeiieo ?aaaia?aoi?ieo (a?ia?ieanoe/ieo) i?ioean?a. ?aaaia?aoe?y
ai?oae?y ie?ie aea/aia iaaeinoaoiuei oa i?aeoe/ii aeeeth/ii ia oaa?eiao,
ui ?inoooue aanue ia??iae aeeooy — uo?e oa ieo?, oiio oe? ?acoeueoaoe
o?aaa aeoaea iaa?aaeii aeno?aiiethaaoe ia ?aaaia?aoe?th ie?ie o ?ioeo
nnaaoe?a oa ethaeae.

Aaaaeaiiy iaioeaeiiai eiiieaeno ie?ie ca oiia ?icaeoeo
aenia?eiaioaeueieo iaoieia?e i?enei?thaaei a?aeiiaeaiiy ooieoe?iiaeueieo
aeaiaio?a ie?ee. Aeine?aeaeaiiy i?iaeaiiino?oaaee, ui iaioeaeiee
eiiieaen caeaoai i?aeneethaaoe a?ineioac AeIE (aeeth/aiiy 3I-o?i?ae?io)
a ie?eao a i?aaiicaeaaeiee niin?a. Ca oiia iao?aeoii?? eiio?eaoa?aeueia
ie?ea i?ae aieeaii iaioeae?a oaeae/a a?aeiiaethaaea na?e
ooieoe?iiaeueiee noai, nei??o aaeaiooaaeanue aei c?inoaiiy ianya?a
o?eueo?aoe??, yaeua a?ia?o?io?? aoee a?eueo ae?aaeaieie, i?ae a
eiio?ieueieo oaa?ei.

Ioaea, iaioeaee aieiaiiai eiiieaeno a?noinoi?niino? i?ae /an aaaaeaiiy
oaa?eiai c iioeiaeaeaiiyi ie?eiai? oeaieie ??cii? ao?ieia??
i?enei?ththoue ?icaeoie eiiiainaoe?eii-i?enoinoaaeueieo ?aaeoe?e oa
?aaaia?aoe?th ie?eiai? ia?aioeie.

Inoaiia ieoaiiy, yea ia iao iiaeyae iio?aao? iaaiai?aiiy, oea iaoai?ci
aca?iiae?? iaioeae?a c O-ee?oeiaie: aca?iiae?thoue iaioeaee c
O-ee?oeiaie naiino?eii /e a eiiieaenu c iieaeoeaie AEAN? sseui iaioeae
aca?iiae?? c iieaeoeith AEAN, oi ye aaaaeaiee a na?aaeiaeua a?eueiee
iaioeae aca?iiae?? c iieaeoeith AEAN, a yeo ca o?c?ieia?/ieo oiia aaea
aaoaeiaaii iaioeae?

Ia oea ieoaiiy iiaeooue aeaoe a?aeiia?aeue ?iaioe Aacaeueneiai ?inoeoooo
?ioiieia??, a yeeo iieacaii, ui ia iiaa?oi? aioeaai-i?acaiooth/eo ee?oei
iaeaea caaaeaee ?niothoue (iniaeeai a oiiaao, iani?eyoeeaeo aeey ee?oei,
iai?eeeaae, iecueea oaiia?aoo?a) a?euei? a?ae iaioeaea iieaeoee AEAN,
aea aeoaea ia noaa?euei?. Noaa?e?caoe?y aeinyaa?oueny i?ney aca?iiae?? c
iaioeaeaie ?c ciaieoiueiai na?aaeiaeua. Ooai?aiee eiiieaen, ui aeoaea
aaaeeeai, iiaea aca?iiae?yoe c aaeeeei /eneii ?aoeaioi??a [Vallitutti
S., Lanzavecchia A., 1995].

Aca?iiae?y eiiieaena iaioeae-AEAN c O-ee?oeiiei ?aoeaioi?ii iiaea
i?eaiaee aei ??cieo iane?aee?a, a?ae iiaii? aeoeaaoe?? O-ee?oei aei
ioeue-?aaeoe?? [Evavold B.D., Sloan-Lancaster J., Allen P.M., 1993].

Oeae oaiiiai a na?oia?e i?aeoeoe? ca?ac iaaoaa? cia/ii? oaaae, caaaeyee
aeei?enoaiiy neioaoe/ieo iaioeae?a ye e?ea?nueeeo i?aia?ao?a [Ii?icia
A.A., *aeeniaa I.E., Ieoeia A.A., 1998].

Iai?eeeaae, aia?eeainueea eiiiai?y «ImmuLogic Pharmaceutical
Corporation” (Ianna/onao) ?ic?iaey? «iaioeaei? aaeoeeie» aeey aeinyaaiiy
oiea?iaaiieo aoaeo?a [Norman Ph.S. et al., 1997; Nicodemus C. et al.,
1997]. Oiio c?icoi?ei, ui iaioeaeiee eiiieaen ie?ie, yeee aeyaea
ae?aaeaio oa?aiaaoe/io aeoeai?noue ca oiia iao?iiaoieia??, ca?ac
i?ioiaeeoue aeiee?i?/i? aei?iaoaaiiy ye iiaee e?ea?nueeee i?aia?ao.
Iaeiae, iaeaooia aac noii?a?a iaeaaeeoue eiai neioaoe/iei aiaeiaai.

AENIIAEE

1. Iaioeaeiee eiiieaen, yeee aeno?aao?oueny c ie?ie ca aeiiiiiaith
i?aai?/ieo eeneio a i?enooiino? eaoeii?a aeaioaaeaioieo iaoae?a,
aoe?eiio iaaeaiee iaioeaeaie aieiaiiai eiiieaeno a?noinoi?niino?.

2. Iaioeaeiee eiiieaen ie?ie caeaoai ci?ithaaoe ooieoe?iiaeueiee noai
e?ioioeeo?a ia??oa??/ii? e?ia? (i?aeaeuaiiy aeni?an?? CD3, CD4, HLA-DR c
aeoeaaoe??th o aeaeyae? eai?iao oa eeanoa??caoe??, cieaeaiiy — CD22 oa
iacia/ii CD8) oa ooieoe?iiaeueio ii?oieia?th oeiona a o?c?ieia?/ieo
oiiaao oa i?ae /an ?ioi?caoe?? oeioncaeaaeieie aioeaaiaie.

3. I?e?iaeiee iaioeaeiee eiiieaen ie?ie aieiae?? caeaoi?noth aeoeaoaaoe
o?a??iie?c oa aeieoaaoe ia?aoai?aiiy o?iia?io, ui a?aeiia?aea?
ooieoe?iiaeueiei iniaeeainoyi i?aaio, ca o?c?ieia?/ieo oiia oa i?ae
/an ?icaeoeo iaoieia?? ie?ee.

4. Iaioeaeiee eiiieaen ie?ie caiia?aa? ?icaeoeo aioeaainiaoeeo?/ii?
a?aeiia?ae? ia aioeaai ie?eiai? oeaieie ca oiia aenia?eiaioaeueii?
iaoieia?? (aooi?ioiiee iao?eo, iie?eiiiiiaioiay ?ioiiiaoieia?y,
aeio?ainieaioaoe?y ie?ee) oa i?ae /an aianaiiy o e?ia oai?eo ia
o?ii?/iee aeiia?oeiiao?eo.

5. Ca oiia aooi?ioiiiai iao?eoo ci?ith?oueny niaeo? iaioeae?a ie?eiai?
oeaieie (cieeathoue aai aeieeathoue iaioeaei? o?aeoe??, ci?ith?oueny ?o
ni?aa?aeiioaiiy), aaaaeaiiy aeciaaiiiai iaioeaeiiai eiiieaeno aeeeeea?
a?aeiiaeaiiy niaeo?o iaioeae?a ie?ie.

6. Ie?ai? o?aeoe?? iaioeaeiiai eiiieaeno ie?ie caeaoi? aieeaaoe ia Eii-A
?iaeoeiaaio i?ie?oa?aoe?th ieoeieo nieaiioeeo?a oa ?E-2 ?iaeoeiaaio —
ee?oei e?i?? CTLL (ND8+). A?eueo a?ae?ioiai? o?iiaoia?ao?/i? o?aeoe??
i?aeneethaaee i?ie?oa?aoe?th, a?ae?io?euei? — cieaeoaaee o oa?aeoa?i?e
aeicicaeaaei?e iaia?? («aeca?iiiiae?ai?» e?ea?).

7. Ie?ee iathoue niaoeeo?/iee iaa?? iaioeaeieo ?a/iaei, yeee
a?ae??ciy?oueny a?ae oaeiai a oeaieiao naeac?iee, oeiona, i?aeoeoieiai?
caeice, ia/?iee, ia?iaeiioo. A neeaae? oeueiai eiiieaeno aeyaeaii
o?aaiaioe ?ineeii-(55-66; 56-66) oa aeueoa-(48-61)- eaioetha?a
aaiiaeia?io, oa?ea?o?ia (1-20).

8. Iaioeaeiee eiiieaen ie?ie i?noeoue o?aeoe??, ye? caeaoi? ca’ycoaaoeny
c iieaeoey?ieie oaia?iiaie Hsp70, ye? iiaeooue a?aoe o/anoue a
?aae?caoe?? ae?? oaeeo iaioeae?a.

9. Caaaeueiith noaiith aoaeoaaiiy iaioeaeiiai eiiieaeno ie?ie ?: a
iieiaeaii? 1 — i?ie?i, a 2 — aae?i, ania?aa?iiaa oa aeooai?iiaa eeneioe,
a 3 — e?c?i, a 4 — ania?aa?iiaa eeneioa, a 6 — a?a?i?i.

10. Neioaoe/i? iaioeaee — aiaeiae i?e?iaeiiai iaioeaeiiai eiiieaeno
ie?ie (i?i-aeo-e?c-ani-eae-a?a-e?c, i?i-aeo-e?c-ani-na?-a?a-e?c,
i?i-aeo-e?c-ani-ani-a?a-eae) i?ae /an aianaiiy o e?ia aeiii??a
cieaeoaaee a?aenioie oaio?e?i-?acenoaioieo ee?oei, i?aeaeuoaaee —
oaio?e?i/ooeeaeo, aeoeaoaaee oaaioeeoa?i? ooieoe?? IIssE, ca oiia
aooi?ioiiiai iao?eoo a?aeiiaethaaee ?ioiieia?/io oiea?aioi?noue,
aeyaeyee o?ioni?ioaeoeaiee aoaeo, i?enei?thaaee ?aaaia?aoe?th ia?aio?ie
ie?ie. Iaea?eueo aeoeaiei aeyaeany iaioeae i?i-aeo-e?c-ani-na?-a?a-e?c.

11. Iaioeaee aieiaiiai eiiieaeno a?noinoi?niino? ie?ie iathoue oaeiae
aeanio o?c?ieia?/io aeoeai?noue ia iia’ycaio c i?acaioaoe??th aioeaaia
oa ?ioiiei ?ici?ciaiiyi, ni?yiiaaio ia i?aeo?eieo iaoaaie?/ieo oa
?aaaia?aoi?ieo i?ioean?a a ie?eao.

I?AEOE*I? ?AEIIAIAeAOe??

1. Ia i?aenoaa? i?iaaaeaieo aeine?aeaeaiue aeioe?eueii ?aeiiaiaeoaaoe
i?e?iaeiee iaioeaeiee eiiieaen ie?ie aeey i?iaaaeaiiy ee?i?/ieo ?nieo?a,
ye i?aia?aoa aeey e?eoaaiiy aooi?ioiieo caoai?thaaiue ie?ie.

2. Ia?niaeoeaia iiaeaeueoa aea/aiiy neioaoe/ieo aiaeia?a i?e?iaeiiai
iaioeaeiiai eiiieaeno ie?ie ye iioaioe?eieo e?ea?nueeeo ?a/iaei.

3. Cai?iiiiiaaiee iaoiaee/iee i?aeo?ae aeey ni?yiiaaiiai neioaca
a?ieia?/ii aeoeaieo iaioeae?a ?c caaeaieie aeanoeainoyie iiaea aooe
aeei?enoaiee aeey noai?aiiy iiaeo e?ea?nueeeo i?aia?ao?a.

NIENIE IIOAE?EIAAIEO AAOI?II I?AOeUe CA OAIITH AeENA?OAOe??

1. A?aeiiaeaiiy iaioeaea?a?/ii? ?aaoeyoe?? o ie?eao aeciaaiieie
iie?iaioeaeieie ?a/iaeiaie ?aiaeueiiai iioiaeaeaiiy. Oeceieiae/aneee
aeo?iae.- 1992.- O.38, N 6.-N. 106-109.

2. Aeeyiea ii/a/iuo iieeiaioeaeia ia aeoeaiinoue eeioioeeoia i?e
yenia?eiaioaeueiii iao?eoa. Oeceieiae/aneee aeo?iae.-1993.-O.39,
N5-6.-N.52-56

3. Iaoai?cie ooai?aiiy oa ae?? iie?iaioeaeieo
a?i?aaoeyoi??a-oeeoiiaae?i?a. O?c?ieia?/iee aeo?iae.-
1994.-o.40,N1.-N.51-64.

4. Aeeyiea iieeiaioeaeiiai eiiieaena oeaiae ii/ae ia aeoeaiinoue
eeioioeeoia aeiii?neie e?iae. Eiioiieiaey// 1995.- N4.-N.31-33.

5. N?aaieoaeueiia eco/aiea o?iiaoia?aoe/aneeo niaeo?ia iieeiaioeaeia,
yeno?aae?iaaiiuo ec naeacaiee, ia/aie, ii/ae, oeiona, ia?iaeiioa naeiae.
Oe?. aeioei. aeo?i..- 1995.-o.67,N5.-N.85-89.

6. Aea/aiiy niaoeeo?/ii? ae?? iaioeaeiiai eiiieaeno ie?ie i?ae /an
oi?eaoa?aeueii? iao?aeoii?? c aeinoaoe/iith o?ainieaioaoe??th ie?ee o
uo??a. OA?IAEII.-1995.-N11-12.-N. 31-37.

7. Oeaiaaay niaoeeoe/iinoue iaioeaeiuo yeno?aeoia, auaeaeaiiuo ec
?acee/iuo i?aaiia, e eiioii?aaoeyoi?iia aeaenoaea iaioeaeiiai yeno?aeoa
ii/ae. Aeiiieeia?u e eeaoea.- 1995.-N5, o.11.-N.61-75.

8. Onoaiiaeaiea niaeaniaaiiie iineaaeiaaoaeueiinoe ioea iaioeaeiuo
o?aeoeee, auaeaeaiiuo ec ei?eiaiai aauanoaa ii/ae.
Eiioiieiaey.-1996.-N2.- N. 24-28

9. Aeeyiea ioaeaeueiuo iaioeaeiuo o?aeoeee, auaeaeaiiuo ec ei?eiaiai
aauanoaa ii/ae, ia i?ieeoa?aoeaioth aeoeaiinoue eaeeioeeoia.
Eiioiieiaey.-1996.-N3.- N.30-33

10. Aieea ie?eiaeo iie?iaioeae?a ia aaiieiaaoeyoe?th oa ia?aeenia
ieeneaiiy e?i?ae?a i?e aino?iio aiioe?eii-aieueiaiio no?an?.
O?c?ieia?/iee aeo?iae.- 1996.-O.42,N5-6.-N.39-43

11. Aeeyiea ii/a/iuo iaioeaeia-oeeoiiaaeeiia ia aaiieiaaoeyoeeth e
ia?aeeniia ieeneaiea eeieaeia i?e yenia?eiaioaeueiii iao?eoa
Oaeiaia.Iaoieiae/aneay oeceieiaey.- 1991.-N 5.-N. 35 — 36 (Niaaoi?u
Ieuaiei A.I., Neeaiei TH.E., Oaaeinii A.O.).

12. Aieea ?aaoeyoi?ieo ie?eiaeo iie?iaioeae?a ia aaiieiaaoeyoe?th ?
ia?aeenia ieeneaiiy e?i?ae?a i?e ooi?eno?e ?ioieneeaoe??.
Oeceieiae/aneee aeo?iae.- 1993.- O.39, N 2-3.-N.67-71. (Ni?aaaoi?e
Eao?ooia A.A., I?uaiei A.I.).

13. Iaoiaee/aneea iiaeoiaeu e i?iaaaeaieth ne?eieiaa aeieiae/aneie
aeoeaiinoe iaioeaeiuo aauanoa. I?iaeaie aeieia?? oa iaaeeoe?ie.
-1997.-T1,N1-2.-C.12-17. (Ni?aaaoi? Eao?ooia A.A.).

14. Eco/aiea oa?aiaaoe/aneie aeoeaiinoe neioaoe/aneeo iaioeaeia-aiaeiaia
anoanoaaiiiai iaioeaeiiai eiiieaena ii/ae ia iaeioi?ua iieacaoaee
aiiainoaca o oiiyeia i?e aooieioiiii iao?eoa. I?iaeaie aeieia?? oa
iaaeeoe?ie.-1997.-T1,N1-2.-C.24-26. (Ni?aaaoi? Aaeei I.A.).

15. Niaoeeo?/i? ci?ie aaiinoaoe/ii? ?aaeoeaiino? oaa?ei a iani?eyoeeaeo
oiiaao ciai?oiueiai na?aaeiaeua oa ?o ei?aeoe?y ca aeiiiiiaith i?aaiieo
iaioeaeieo aeno?aeo?a. Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu.-1997.-N25.-C.19-26.

16. Aeeyiea iaioeaeiiai eiiieaena ii/ae ia yeni?anneth iiaa?oiinoiuo
?aoeaioi?ia eeioioeeoia a oneiaeyo naycuaaiey aiaeeaoi/iiai eaeueoeey.
I?iaeaie aeieia?? oa iaaeeoeeie.-1998.-2,N1-2.-C.34-37.(Ni?aaaoi?e
Aanieia E.Y., Nieieaiei A.I.).

17. Aieea ie?eiaeo iaioeae?a ia ii?oiooieoe?iiaeueiee noai o?iona ca
o?c?ieia?/ieo oiia oa i?ae /an ?icaeoeo aooi?ioiiiai iao?eoa. I?iaeaie
aeieia?? oa iaaeeoeeie.-1998.-2,N1-2.-C.38-40.

18. Acaeiiaeaenoaea iaioeaenaycuaathueo aaeeia Hsp70 n iaioeaeiui
yeno?aeoii ii/ae. Aanoiee i?iaeai aeieiaee e
iaaeeoeeiu.-1998.-N11.-C.67-70.

19. Aieea iaioeaeiiai eiiieaeno ie?ie ia i?ioeane ?ioi?oaoo oa
ianiaoeeo?/ii? ?acenoaioiino? ca oiia iie?eiiiiiaioii? ?ioiiiaoieia??.
Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.-1998.-N11.-C.63-67.

20. O/anoea iaioeaeiiai eiiieaena ii/ae a ?aaoeyoeee yeni?annee
iaeioi?uo ?aoeaioi?ia eaeeioeeoia. Eiioiieiaey. -1998. -N4.-C.13-16.
(Ni?aaao. Aanieia E.?.).

21. I?aia?ao oeaieiieo a?ieia?/ii aeoeaieo ?a/iaei yeee ia?
?aaaia?aoi?io ae?th oa niin?a eiai iaea?aeaiiy. Iaoaio Oe?a?ie N5743.
(Ni?aaoi?e I.A.Eao?ooia I.?.Oeaa?aeeinueeee, *oiaeia I.A., Eenaiei N.I.,
Caeeaaeiee A.I., Nooioeinueeee A.E.).

22. A.n.10180A. Oe?a?ia. IE? 5 A61 E37/00. Niin?a iaea?aeaiiy a?ieia?/ii
aeoeaii? ?a/iaeie, ui ia? ?aaaia?aoi?io oa iiaeoethth/o ae?th/
I?iieneiaa aeani?noue.-1996.-N3.-C.3.1.76-3.1.77. (Ni?aaaoi?
I.A.Eao?ooia).

23. Consesnsus sequence of peptide fractions’ pool obtained from kidney’
cortex substances and its immunoregulative influence. European Journal
of Physiology// 1995.-V.430, N4.-R48.

24. The new group of biological regulators for multicellular systems —
peptides of major histocompartibility complex/Biological
Chemistry.-1998.-v.379,September, Suppl..-S.82.

25. Aeeyiea ii/a/iuo iaioeaeia-oeeoiiaaeeiia ia aaiinoac, ia?aeeniia
ieeneaiea eeieaeia e iaeioi?ua iieacaoaee ianiaoeeoe/aneie ?ace
noaioiinoe i?aaiecia i?e yenia?eiaioaeueiii iao?eoa. Oacenu aeieeaaeia
iao/iii?aeoe/aneie eiioa?aioeee «Iiene iiauo eaea?noaaiiuo n?aaenoa e eo
eniieueciaaiea a eeeieea», *eoa, 1990, n. 11 (Ni?aaaoi? Neeaiei TH.E.).

26. Aeeyiea ii/a/iuo iieeiaioeaeia-oeeoiiaaeeiia ia aaiinoac, ia?aeeniia
ieeneaiea eeieaeia e iaeioi?ua iieacaoaee ianiaoeeoe/aneie
?acenoaioiinoe i?aaiecia. Nai?iee iaoa?eaeia XIII nuacaea Oe?aeineiai
oeceieiae/aneiai iauanoaa, Oa?ueeia,1990,n. 128. (Ni?aaaoi?e Ieuaiei
A.I., Enaic E.A.).

27.Eniieueciaaiea iieeiaioeaeiiai i?aia?aoa ii/ae a yenia?eiaioaeueiie
oa?aiee. «?aaoeyoi?iua iieeiaioeaeu a ii?ia e iaoieiaee» Na. iao/i.
?aaio iiae ?aae. A.E.Eocieea.*eoa,1991, n. 24.

28. Aieea iieiiaioeaeia,aeaeieaieo c ie?ie, ia i?ioeane ia?ieneaeiiai
ieeneaiiy eiiiaeia i cniaeaiiy e?iai. Oace aeiiiaiaeae VI Oe?a?inueeiai
aiioiii/iiai c’icaeo. Eeia. 1992. *anoeia 1.,N.187. (Ni?aaaoie Eooeaiei
E.I. Ia?eaeithe I.Ae. Aia?iaa I.A.).

29.Aeeyiea aei?aaoeyoi?a iieo/aiiiai ec ii/ae, ia ia?aeeniia ieeneaiea
eeieaeia, aaiinoac e ianiaoeeoe/aneoth ?acenoaioiinoue i?aaiecia. Oacenu
neiiiceoia «Iaioeaeiua aei?aaoeyoi?u-oeeoiiaaeeiu»,
Naieo-Iaoa?ao?a,1992,N.72-73.(Ni?aaaoi?e Eao?ooia A.A., Ieuaiei A.I.).

30. Aiciiaeiinoue iaaenenoaiiiai iiaeoiaea a eco/aiee iaoaieciia
aeaenoaey oeeoiiaaeeiia. Oacenu neiiiceoia «Iaioeaeiua
aei?aaoeyoi?u-oeeoiiaaeeiu», Naieo-Iaoa?ao?a,1992, N.73-74.(Ni?aaaoi?e
Eao?ooia A.A., Ieuaiei A.I.).

31. Iaioeaea?a?/ia ?aaoeyoe?y i?aia?aoaie oeeoiiaae?i?a a i?aai?ci?.
Iao/iua o?oaeu o?aoueaai iaaeaeoia?iaeiiai neiiiceoia »
Nenoaiii-aioenenoaiiay ?aaoeyoeey a aeeaie e iaaeeaie i?e?iaea», Eeaa,
10-13 iiya?y 1993, Eeaa-1993,N.91-96. (Ni?aaaoi?e Eao?ooia I.A.,
Oeaa?aeeinueeee I.?., I?uaiei A.I.).

32. Noai?aiiy neioaoe/iiai iaioeaeiiai i?aia?aoo — aiaeiao i?e?iaeiiai
iaioeaeiiai eiiieaena ie?ie. No/ani? i?iaeaie oa?iaeieia??/ Oace
aeiiia?aeae ? iaoe?iiaeueiiai c’?caeo oa?iaeieia?a Oe?a?ie. -Ee?a,
1995.-N.69.

33. Ia?niaeoeae noai?aiiy iiaeo e?ea?nueeeo cania?a iie?iaioeaeii?
i?e?iaee. No/ani? i?iaeaie oa?iaeieia??/ Oace aeiiia?aeae ?
iaoe?iiaeueiiai c’?caeo oa?iaeieia?a Oe?a?ie.-Ee?a, 1995.-N.70.

34. ?ioiia?ieia?/ia aeoeai?noue i?e?iaeiiai iaioeaeiiai eiiieaeno ie?ie
oa eiai neioaoe/ieo aiaeia?a. Ca??ea oac ? Iaoe?iiaeueiiai eiia?ano
Oe?a?ie c ?ioiieia??, aea?aieia?? oa ?ioii?aaa?e?oaoe?? (Aeoooa, 13-15
o?aaiy 1998).-Ee?a, 1998.-N.88.

AIIOAOe?ss

Eaeaeaoaa ?.I. ?aaoeyoi?iee i?e?iaeiee iaioeaeiee eiiieaen ie?ie:
io?eiaiiy, o?ceei-o?i?/i? aeanoeaino?, ca’ycie c aieiaiei eiiieaenii
a?noinoi?niino?, ?ioiia?ieia?/i? aoaeoe oa ?ic?iaea oa?iaeieia?/ii?
?a/iaeie.-?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca
niaoe?aeuei?noth 14.03.08 — ?ioiieia?y oa aea?aieia?y.- Iaoe?iiaeueiee
iaaee/iee oi?aa?neoao ?iai? aeaaeai?ea I.I.Aiaiiieueoey, Ee?a, 1999.

Iaioeaeiee eiiieaen ie?ie, yeee aeno?aao?oueny ca aeiiiiiaith i?aai?/ieo
eeneio a i?enooiino? aeaioaaeaioieo eao?ii?a ca ?ic?iaeaiei iaoiaeii,
neeaaea?oueny c iaioeae?a ca’ycaieo c iieaeoeaie aieiaiiai eiiieaeno
a?noinoi?niino? ia?aaaaeii ? eeano. Oeae eiiieaen cae?enith? ca’ycie
i?ae ee?oeiaie ie?ee oa ?ioiioeeoaie. Iaioeaee aieiaiiai eiiieaeno
a?noinoi?niino? iathoue aeanio o?c?ieia?/io aeoeai?noue, yea
ni?yiiaaia ia i?aeo?eieo iaoaaie?/ieo oa ?aaaia?aoi?ieo i?ioean?a.

A oiiaao aooi?ioiii? iaoieia?? ie?ee iaioeaeiee eiiieaen aeieo?
aioeaainiaoeeo?/io a?aeiia?aeue ia oeaieiiee aioeaai ie?ee. Iaioeaeiee
eiiieaen ie?ie oa eiai neioaoe/i? aiaeiae iathoue ae?aaeaio oa?aiaaoe/io
aeoeai?noue ca oiia aenia?eiaioaeueii? ?ioiiiaoieia?? ie?ie, ui
aeicaiey? i?iiiioaaoe ?o iiaeaeueoa aea/aiiy ye oa?iaeieia?/ieo ?a/iaei.

Eeth/ia? neiaa: iaioeaee, aieiaiee eiiieaen a?noinoi?niino?, ie?ee,
aooi?ioiia iaoieia?y.

AIIIOAOeEss

Eaeaeaoaa E.I. ?aaoeyoi?iue i?e?iaeiue iaioeaeiue eiiieaen ii/ae:
iieo/aiea, oeceei-oeie/aneea naienoaa, naycue n aeaaiui eiiieaenii
aenoiniaianoeiinoe, eiioiiaeieiae/aneea yooaeou e ?ac?aaioea
oa?iaeieiae/aneiai aauanoaa.-?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii
niaoeeaeueiinoe 14.03.08 — eiioiieiaey e aeea?aieiaey.- Iaoeeiiaeueiue
iaaeeoeeineee oieaa?neoao eiaie aeaaeaieea I.I.Aiaiiieueoea, Keaa, 1999.

Iaioeaeiee eiiieaen ii/ae, eioi?ue yeno?aae?oaony n iiiiuueth
i?aaie/aneeo eeneio a i?enoonoaee aeaooaaeaioiuo eaoeiiia ?ac?aaioaiiui
niiniaii ninoieo ec iaioeaeia, naycaiiuo n iieaeoeaie aeaaiiai eiiieaena
aenoiniaianoeiinoe i?aeiouanoaaiii 1 eeanna. Yoio eiiieaen inouanoaeyao
naycue iaaeaeo eeaoeaie ii/ae e eiioiioeeoaie.

A ?aaioa eniieueciaaiu eiioiieiae/aneee, aeioeie/aneee,
o?iiaoia?aoe/aneee e aenoieiae/aneee iaoiaeu enneaaeiaaiee. Ioeaiea
i?ieeoa?aoeaiie niiniaiinoe eeaoie i?iaiaeeeanue ii aeeth/aieth
3I-oeieaeeia. Enneaaeiaaiey i?iaaaeaiu ia iiaeaeyo aooieiioiiiai
iao?eoa, ni/aoaiiie eiioiiiaoieiaee (iaeiia?aiaiiue aooieiioiiue ioaao
ia aaeee nuai?ioee e?iae e ii/a/iua aioeaaiu), iao?yeoiiee n
aeinoaoe/aneie o?ainieaioaoeeae, ino?iai yiioeeiiaeueii-aieaaiai
no?anna. E?iia oiai, i?iaaaeaiu iiaeaeueiua iiuou ia caei?iauo
aeeaioiuo, e?iae aeiii?ia e aieueiuo aeiia?oeiiao?eoii.

?acoeueoaou i?iaaaeaiiuo enneaaeiaaiee iieacaee, /oi iaioeaeu aeaaiiai
eiiieaena aenoiniaianoeiinoe eiatho nianoaaiioth oeceieiae/aneoth
aeoeaiinoue, eioi?ay iai?aaeaia ia iiaeaea?aeaiea iaoaaiee/aneeo e
?aaaia?aoi?iuo i?ioeannia.

Iaioeaeiue eiiieaen ii/ae niiniaai oneeeaaoue yeni?anneth CD3, CD4,
HLA-DR e nieaeaoue — CD22 ia eaeeioeeoao ia?eoa?e/aneie e?iae. I?e
aaaaeaiee aeeaioiui yoio eiiieaen ieacuaaao aeeyiea ia
ii?oi-ooieoeeiiaeueiia ninoiyiea oeiona a oeceieiae/aneeo oneiaeyo e i?e
eiioiecaoeee oeioncaaeneiuie aioeaaiaie, aucuaay oneeaiea i?ieeoa?aoeee
oeiioeeoia e eo auoiaea ec oeiona a e?iaioie.

?acaeoea aooieiioiiiai iao?eoa Oaeiaia i?eaiaeeo e eciaiaieth
o?iiaoia?aoe/aneiai niaeo?a eiiieaena iaioeaeia, yeno?aae?oaiiai ec
ei?eiaiai aauanoaa ii/ae, /oi naeaeaeuenoaoao i ia?ooaiee iaioeaeiie
?aaoeyoeee. Aaaaeaiea yeciaaiiiai iaioeaeiiai eiiieaena ii/ae i?eaiaeeo
e ainnoaiiaeaieth niaeo?a yeno?aae?oaiuo iaioeaeia, /oi niioaaonoaiaaei
ainnoaiiaeaieth ii?iaeueiiai ii?oiooieoeeiiaeueiiai ninoiyiey ii/ae.

A oneiaeyo aooieioiiie iaoieiaee ii/ae (iao?eo Oaeiaia,
aeeio?ainieaioaoeey ii/ae, ni/aoaiiay eiioiiiaoieiaey) iaioeaeiue
eiiieaen aeiee?oao aioeaainiaoeeoe/aneee ioaao ia oeaiaaie aioeaai
ii/ae, ii i?aeoe/anee ia aeeyao ia i?ieeoa?aoeeth eeaoie ia ieoiaai
eiieaiaaaeei-A.

Iaeaeaia niiniaiinoue i?e?iaeiiai iaioeaeiiai eiiieaena ii/ae
aeoeae?iaaoue oea?eiieec e aeiee?iaaoue i?aa?auaiey o?iiaeia, /oi
ioaa/aao ooieoeeiiaeueiui iniaaiiinoyi i?aaia a oeceieiae/aneeo oneiaeyo
e i?e ?acaeoee iaoieiaee ii/ae.

Iaioeaeiue eiiieaen ii/ae e aai ioaeaeueiua o?aeoeee ieacuaatho aeeyiea
ia eiieaiaaaeei-A e eioa?eaeeei-2 eiaeooee?iaaiioth i?ieeoa?aoeeth
iuoeiuo nieaiioeeoia e eeaoie eeiee CTLL. Ioaeaeueiua o?aeoeee
iaioeaeiiai eiiieaena niiniaiu acaeiiaeaenoaiaaoue n iieaeoey?iuie
oaia?iiaie Hsp70.

I?e enneaaeiaaiee aieiieeneioiuo iineaaeiaaoaeueiinoae iaioeaeia n
iaeaieueoei oaeaeueiui aanii a i?e?iaeiii iaioeaeiii eiiieaena ii/ae
iaia?oaeaiu o?aaiaiou eineeii- (55-66, 56-66) e aeueoa- (48-61) oeaiae
aaiiaeiaeia e oaeeaeoeia (1-20).

Ii?aaeaeaia iauay noaia no?iaiey iaioeaeiiai eiiieaena ii/ae: a 1
iieiaeaiee – i?ieei, ai 2 – aaeei, ania?aaeiiaay eee aeooaieiiaay
eeneiou, a 3 – eecei, a 4 – ania?aaeiiaay eeneioa, a 6 — a?aeiei.
Ciaiea iauae noaiu no?iaiey iaioeaeiiai eiiieaena iicaieeei ?ac?aaioaoue
oi?ioeu neioaoe/aneeo aiaeiaia. Aeoeaiinoue neioaoe/aneeo aiaeiaia
(i?i-aeo-eec-ani-eae-a?a-eec, i?i-aeo-eec-ani-na?-a?a-eec,
i?i-aeo-eec-ani-ani-a?a-eae) auea enneaaeiaaia ia iiaeaee aooieiioiiiai
iao?eoa.

Iaioeaeiue eiiieaen ii/ae e aai neioaoe/aneea aiaeiae eiatho
au?aaeaiioth oa?aiaaoe/aneoth aeoeaiinoue a oneiaeyo yenia?eiaioaeueiie
eiioiiiaoieiaee ii/ae: aeoeaaoeey oaaioeeoa?iuo ooieoeee, ainnoaiiaeaiea
eiioiieiae/aneie oiea?aioiinoe, ieacuaatho oeioni?ioaeoi?iue yooaeo,
onei?ytho ?aaaia?aoeeth ia?aioeiu ii/ae. Iaeaieaa aeoeaiui ec
neioaoe/aneeo iaioeaeia ieacaeny i?i-aeo-eec-ani-na?-a?a-eec. Yoe
aeaiiua iicaieytho i?aaeeiaeeoue eo aeaeueiaeoaa enneaaeiaaiea eae
oa?iaeieiae/aneeo aauanoa.

Eeth/aaua neiaa: iaioeaeu, aeaaiue eiiieaen aenoiniaianoeiinoe, ii/ee,
aooieiioiiay iaoieiaey.

SUMMARY

Kaidashev I.P. Regulative natural peptide complex of kidneys: obtaining,
physical and chemical properties, connection with major
histocompartibility complex, immunobiological effects and the working
out of pharmacological substance.-Manuscript.

Dissertation for the academic degree of the Doctor of Medical Sciences
in the speciality 14.03.08 — Immunology and Allergology.- National
Medical University name A.A.Bogomoletz, Kiyv, 1999.

Peptide complex which was obtained by organic acid extraction with
cations consisted of peptides connected with I class molecules of major
histocompartibility complex (MHC). This peptide complex make connection
between kidney cells and immunocytes. MHC peptides has own phisiological
activity for the supporting of metabolic and repair process.

By the kidney autoimmune pathologies peptide comlex blocked autoimmune
responce to kidney tissue antigen. Kidney peptide complex and its
synthetic analogues has expressive therapeutic activity by the
experimental kidney immunopathologies. This findings suggest the further
investigation of these substances as pharmacological agents.

Key words: peptides, major histocompartibility complex, kidney,
autoimmune diseases.

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