Рання діагностика діабетичних нефропатій у хворих на інсулінзалежний цукровий діабет: Автореф. дис… канд. мед. наук / О.Ч. Таджієва, Ін-т ендокринол

10

?INOEOOO AIAeIE?EIIEIA?? OA IAI?IO ?A*IAEI

?i. A. I. Eii?na?aiea

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

OAAeAE??AA Iaoeueaeaea?ai *a?eeoe??aia

OAeE 616.379-008. 64: 616.61] – 07

?AIIss Ae?AAIINOEEA Ae?AAAOE*IEO IAO?IIAO?E O OAI?EO

IA ?INOE?ICAEAAEIEE OeOE?IAEE Ae?AAAO

14.01.14 — aiaeie?eiieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a ?inoeooo? aiaeie?eiieia?? oa iai?io ?a/iaei

?i. A. I. Eii?na?aiea AII Oe?a?ie, i.Ee?a, oa a ?inoeooo? aa?iioieia??
AII Oe?a?ie

Iaoeiaee ea??aiee:

Aeieoi? iaaee/ieo iaoe, i?ioani?, aeaaeai?e IAI ? AII Oe?a?ie ?o?iia
Aiae??e Naiaiiae/, ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I.
Eii?na?aiea AII Oe?a?ie, i.Ee?a, caa?aeoaa/ ae?aaaoieia?/iiai a?aeae?eo.

Io?oe?ei? iiiiaioe:

Aeieoi? iaaee/ieo iaoe, i?ioani? Aiaeia? Iao?i Ieeieaeiae/,
Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. I. I. Aiaiiieueoey, i. Ee?a,
caa?aeoaa/ eaoaae?e aiaeie?eiieia??.

Eaiaeeaeao iaaee/ieo iaoe aeioeaio ?iiaiaiei Aaeaioeia Aioii?aia,
Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe

?i. I. E. Ooieea, aeioeaio eaoaae?e ?aae?ieia??.

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao,
eaoaae?a aiaeie?eiieia??

Caoeno a?aeaoaeaoueny «2» eenoiiaaea 1999 ?. i 13°° aiae. ia can?aeaii?
niaoe?ae?ciaaii? A/aii? ?aaee Ae.26.558.01 c aiaeie?eiieia?? a ?inoeooo?
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a-114, aoe. Aeoai?iaenueea, 69)

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie
(254114, Ee?a-114, aoe. Aeoai?iaenueea, 69)

Aaoi?aoa?ao ?ic?neaiee «__2__» _____aeiaoiy__________ 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? A/aii? ?aaee

aeieoi? a?ieia?/ieo iaoe
E. I. Eaeeinueea

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue ?iaioe. Ae?aaaoe/ia iao?iiao?y (AeI) caeia? i?ia?aeia
i?noea na?aae i?e/ei nia?oiino? oai?eo ia oeoe?iaee ae?aaao (OeAe) I
oeio. *anoioa ?icaeoeo AeI neeaaea? 40-50% o oai?eo ia I oei ? 15 — 30%
— o oai?eo ia II oei ae?aaaoo (Oanoaeiaa I.A., 1995, 1998; Osterby R.,
1995; Mogensen C. E. 1999). Iaaaciaea oeueiai oneeaaeiaiiy iieyaa? o
aeineoue iia?eueiiio ? iinooiiaiio ?icaeoeo AeI, yea aeiaaee /an
caeeoa?oueny iaiii?/aiith, ine?eueee ia i?iyaey?ony ee?i?/ii. ? o?eueee
aaea i?e ae?aaeai?e noaae?? o?aaeaiiy ie?ie o oai?iai aeyaey?ony
ee?i?/ia neiioiiaoeea, aea ia oeueiio aoai? ?aaeeeaeueii aeiiiiiaoe
iaoe??ioo ia caaaeaee iiaeeeai.

Ia?o? o?e noaae?? AeI, ca eeaneo?eaoe??th N. A. Mogensen (1983), ia
ae?aaiinoothoueny i?e noaiaea?oiiio ianoaaeaii? oai?iai, aea, o?eueee
oe? noaae?? ? cai?ioieie i?e nai?/ani?e ae?aaiinoeoe?. Iiyaa i?ioa?io???
– ia?oi? ?ooeiii? eaai?aoi?ii? iciaee AeI – na?ae/eoue oaea i?i aeeaiea
? iacai?ioia o?aaeaiiy ie?ie. Ioaea, aeey iiia?aaeaeaiiy ?icaeoeo ?
oaeaeeiai i?ia?anoaaiiy ae?aaaoe/iiai o?aaeaiiy ie?ie iaiao?aeii aeoeaii
aeyaeyoe ?aii? noaae?? AeI. ?acii c oei iei? ia ?nio?
caaaeueiii?eeiyoeo, ?ioi?iaoeaieo iaoiae?a aeyaeaiiy ?aii?o noaee?i?/ieo
noaae?e o?aaeaiiy ie?ie o oai?eo ia OeAe.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie. Aeine?aeaeaiiy ? o?aaiaioii
iaoeiai-aeine?aeii? ?iaioe ae?aaaoieia?/iiai a?aeae?eo ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII
Oe?a?ie o 1997-1999 ??. ca oaiith

«Aea/aiiy iiaeo iaoiae?a e?eoaaiiy oeoe?iaiai ae?aaaoo ? eiai
oneeaaeiaiue» (iiia? aea?aeaaii? ?a?no?aoe?? ? 273 ).

Iaoa aeine?aeaeaiiy. Aeyaeoe ? ioa?aeoa?ecoaaoe ?aii? aeiee?i?/i?
noaae?? ?icaeoeo AeI o oai?eo ia OeAe I oeio oa ?ic?iaeoe iaoiaee ?o
?aiiuei? ae?aaiinoeee.

Caaaeaiiy aeine?aeaeaiiy:

1. Aea/eoe o?eueo?aoe?eii-aene?aoi?io ooieoe?th ie?ie o oai?eo ia OeAe I
oeio c ??cieie noaae?yie AeI.

2. Ioe?ieoe noai ie?eiaiai e?iaioieo o iaoe??io?a c ?aii?ie noaae?yie
AeI.

3. Aeine?aeeoe iiaeeea?noue aeei?enoaiiy iaaeeeaiaioicieo i?ia c
?iaeiiaoaoeeiii ? eaioii?eeii aeey aeyaeaiiy noaee?i?/ieo noaae?e AeI.

4. Aeyaeoe iayai?noue aooiaioeo?e aei aacaeueii? iaia?aie eeoai/e?a
(AIE) ie?ie o iaoe??io?a c ??cieie noaae?yie AeI ? c’ynoaaoe cia/aiiy
aooi?ioiieo iaoai?ci?a o oi?ioaaii? oa i?ia?anoaaii? o?aaeaiiy ie?ie o
oai?eo ia ?inoe?icaeaaeiee oeoe?iaee ae?aaao (?COeAe).

5. Ioe?ieoe noai aoii?aeueiiai ?ioi?oaoo o oai?eo ia OeAe I oeio c
??cieie noaae?yie AeI oeyoii aecia/aiiy ?ioiiaeiaoe?i?a ??cieo eean?a ?
?o ni?aa?aeiioaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Iaea?aeai? iia? a?aeiiino? i?i
iniaeeaino? ci?i o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie, ie?eiai?
aaiiaeeiai?ee, ye? i?iyaeythoueny ye ??ciiiai?aaeai? ci?ie oaeeeiiiai
ia’?io eeoai/eiai? o?eueo?aoe??, /ano iaeneiaeueiiai iaeiie/aiiy, /ano
iai?aaeaaaeaiiy ?aae?ioa?ii?aia?aoo, ciaioaiiy oaeaeeino? ie?eiaiai
e?iaioieo ? a?aeiinii? aaiicii? ?iiino? ie?ie o oai?eo c aeiee?i?/ieie
noaae?yie AeI.

Aia?oa ia oe? iaaeeeaiaioicieo i?ia c ?ia?a?oi?ii
aia?ioaiceiia?aoai?thth/iai oa?iaioo (AIO) – eaioii?eeii, ianoa?i?aeiei
i?ioecaiaeueiui i?aia?aoii – ?iaeiiaoaoeeiii, aea/aii oa?aeoa? ci?i
ia?oe?aeueieo ooieoe?e ? aaiiaeeiai?/ieo iieaciee?a ie?ie ia ?aii?o
noaae?yo ?icaeoeo AeI o oai?eo ia I oei OeAe. Iieacaii, ui aeey oai?eo
ia OeAe I oeio c iayai?noth iao?iiao?? oa?aeoa?iei ? ii?ooaiiy
aaeaeaaoii? ?aaeoe?? ia ?iaeiiaoaoeei, ui i?iyaey?oueny a iiaeaeueoiio
ia?inoaii? oaeaeeino? eeoai/eiai? o?eueo?aoe?? (OEO), i?e/iio oe?
ii?ooaiiy ?icaeaathoueny ia ?aii?o noaae?yo iao?iiao??. Anoaiiaeaii, ui
ci?ie ia?aiao??a ie?eiai? aaiiaeeiai?ee o a?aeiia?aeue ia aaaaeaiiy
eaioii?eeo caeaaeaoue a?ae noaae?? AeI ? iiaeooue a?aeia?aaeaoe
?aaeoeai?noue aeiia?oey?ii? aaiiaeeiai?ee.

Aia?oa ioa?aeoa?eciaaii noai aoii?aeueiiai ?ioi?oaoo, aeyaeai?
iniaeeaino? i?iaeoeoe?? ?ioiiaeiaoe?i?a ??cieo eean?a, aioeo?e aei AIE
ie?ie o oai?eo c ??cieie, o oiio /ene? aeiee?i?/ieie, noaae?yie AeI.

A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue iiaeeaeai? oyaeaiiy i?i
iaoio?c?ieia?/i? iaoai?cie oi?ioaaiiy ?aii?o noaae?e o?aaeaiiy ie?ie o
oai?eo ia ?COeAe.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?ic?iaeai? i?aeoe/i?
i?aeoiaee ? iaoiaee aeyaeaiiy ?aii?o, noaee?i?/ieo noaae?e AeI o in?a c
I oeiii OeAe. C oe??th iaoith ?aeiiaiaeo?oueny aeei?enoaiiy iaoiaeo
aeeiai?/ii? ?aiinoeeioea?ao?? c iaioaoaoii, yeee aeicaiey? aeyaeoe ci?ie
e?iaioieo, ia?oe?aeueieo ooieoe?e ie?ie o oai?eo ia OeAe aac ee?i?/ieo
iciae AeI.

Aeei?enoaiiy eaioii?eeiai? i?iae aeicaiey? ioe?ieoe ?aaeoeai?noue
ie?eiai? aaiiaeeiai?ee ? ? ?ioi?iaoeaiei aeey i?iaiico aoaeoeaiino?
o?eaaei? oa?ai?? ?ia?a?oi?aie AIO.

Anoaiiaeaii, ui ii?ooaia ?aaeoe?y ia ?iaeiiaoaoeei, yea i?iyaey?oueny
c?inoaiiyi ii/aoeiai i?aeaeuaii? OEO, ? oa?aeoa?iith iciaeith ?aii?o
noaae?e AeI.

Ciaeaeaii, ui iai?yia aia?ia?ao?y ? ?ioi?iaoeaiei iaoiaeii aeyaeaiiy
ii?ooaiue ie?eiai? aaiiaeeiai?ee o oai?eo ia OeAe aac ee?i?/ii
ae?aaeaii? AeI.

?ic?iaeai? i?aeoiaee aei ae?aaiinoeee AeI o oai?eo ia I oei ae?aaaoo
ai?iaaaeaeai? o ee?i?/io i?aeoeeo ae?aaaoieia?/iiai a?aeae?eo ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie:
aeei?enoiaoaaeanue iaaeeeaiaioicia i?iaa c ?iaeiiaoaoeeiii aeey
aeyaeaiiy ii?ooaiue eeoai/eiai? o?eueo?aoe?? ? nooiaiy
i?e?iaeueaoi?io???, aeeiai?/ia ?aiinoeeioea?ao?y ? ?aae?iioee?aeia
aia?ia?ao?y ie?ie c eaioii?eeii ? ?o ioe?iea c o?aooaaiiyi ee?i?/ieo
neiioii?a.

Oai?aoe/i? iieiaeaiiy aeena?oaoe?eii? ?iaioe caeo/ai? aei eaeoe?eiiai
eo?no caiyoue ia eaoaae?? aiaeie?eiieia?? Oo?eiainueeiai aea?aeaaiiai
iaaee/iiai ?inoeoooo, ia eaoaae?? oaeineiiaeaiiy e?ea??a o Ee?anuee?e
iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I. E. Ooieea.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aeeiiaii: ee?i?/ia
ianoaaeaiiy oai?eo, iaaeeeaiaioicia i?iaa c ?iaeiiaoaoeeiii, noaoenoe/ia
ia?iaea ? iaoeiaa ?ioa?i?aoaoe?y io?eiaieo aeaieo. Aeeiai?/ia
?aiinoeeioea?ao?y, ?aae?iioee?aeia aia?ia?ao?y oa iaaeeeaiaioicia i?iaa
c eaioii?eeii i?iaaaeaia ca o/anoth ae. i. i., i?ioanni?a Neaaiiaa A.
I., aecia/aiiy aioeo?e aei AIE oa ?ioiiaeiaoe?i?a e?ia? i?iaaaeaii ca
o/anoth e. a. i., noa?oiai iaoeiaiai ni?a?ia?oieea eaai?aoi???
iaoio?c?ieia?? oa ?ioiieia?? ?inoeoooo aa?iioieia?? AII Oe?a?ie Ieoaeue
E. I.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ia eiioa?aioe?? ae?aaaoieia?/iiai a?aeae?eo ?inoeoooo
aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A.I. Eii?na?aiea o i. Ee?a?, ia
can?aeaii? eaoaae?e aiaeie?eiieia?? Oo?eiainueeiai aea?aeaaiiai
iaaee/iiai ?inoeoooo (1998), ia can?aeaii? ai?iaaoe?eii? eii?n?? c
ee?i?/ii? aiaeie?eiieia?? ?inoeoooo aiaeie?eiieia?? oa iai?io ?a/iaei
?i. A. I. Eii?na?aiea AII Oe?a?ie (1999).

Ioae?eaoe?y ?acoeueoao?a aeine?aeaeaiiy. ?acoeueoaoe aeena?oaoe??
iioae?eiaai? a 5 noaooyo o oeaio?aeueieo oaoiaeo aeaeaiiyo, 3 noaoo? — o
ni?aaaoi?noa? ? 2 — naiino?ei?.

Ia’?i ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 168 noi??ieao
iaoeiiieniiai oaenoo. Neeaaea?oueny ?c anooio, ?icae?e?a: iaeyae
e?oa?aoo?e, iaoa??aee ? iaoiaee aeine?aeaeaiiy, 5 ?icae?e?a iniaenoeo
aeine?aeaeaiue, iaaiai?aiiy ?acoeueoao?a, aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e ia 142 noi??ieao, nieneo e?oa?aoo?e ia 26 noi??ieao, yeee
i?noeoue 256 aeaea?ae (94 a?o/eciyieo aaoi??a ? 162 caei?aeiiieo).
?iaioa ?ethno?iaaia 19 oaaeeoeyie ? 26 iaethieaie.

CI?NO ?IAIOE

Caaaeueia oa?aeoa?enoeea oai?eo ? iaoiaee ?o ianoaaeaiiy

Aoei ianoaaeaii 153 oai?eo ia OeAe ? oeio, ye? ciaoiaeeeenue ia
e?eoaaii? a ae?aaaoieia?/iii a?aeae?e? ?inoeoooa aiaeie?eiieia?? oa
iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie. Eiio?ieueia a?oia
neeaaeaeanue ?c 32 caei?iaeo in?a, o yeeo i?e ianoaaeaii? cia/aiiy
ae?eiceeueiaaiiai aaiiaeia?io noaiiaeei a?ae 3,3% aei 5,5%, aoee
a?aenooi?ie iciaee iaoieia?? c aieo ie?ie ? na/aaea?aeieo oeyo?a, ia
aoei a?ia?oii?/ii? oai?iae, aeeeth/aia niaaeeiaa iaoyaeaiiy uiaei
oeoe?iaiai ae?aaaoo.

O oe?e ?iaio? ooieoe?iiaeueiee noai ie?ie o oai?eo ia OeAe I oeio
aea/aany ca aeiiiiiaith a?io?i?/ieo, ?aae?i?cioiiieo,
?ioiioeoi?anoeaioiiai ? ?aae?aeueiiai ?ioiiaeeoociiai iaoiae?a
aeine?aeaeaiiy.

Aeey aecia/aiiy noaio o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie,
aea/aiiy aieeao i?eeiio iaeii?aciai? aeice eaioii?eeo ia ooieoe?iiaeuei?
iieacieee ie?ie o 24 oai?eo ia OeAe ? oeio ? o 12 caei?iaeo in?a, ye?
neeaaeaee eiio?ieueio a?oio, i?iaaaeaia aeeiai?/ia ?aiinoeeioea?ao?y ?
?aae?iioee?aeia aia?ia?ao?y ie?ie ia noeeioeeyoe?ei?e aaiia-eaia?? IA
9200 c nenoaiith aaoiiaoe/ii? ia?iaee MICROSEGAMS (Oai?ueia).
Ianoaaeaiiy i?iaiaeeee ca aeiiiiiaith iao?io?iiiiai i?aia?aoo –
aeeaoee?io?eaieiiaioaaoeaoaoo (AeOIA), i?/aiiai ei?ioeiaeeao/ei
?aae?iioee?aeii 99m-On (oaoiaoe??i), yeee aeaiaeeoueny ?c i?aai?cio
ie?eaie ? oaeaee?noue aeaaaeaiiy yeiai caeaaeeoue a?ae aaee/eie
eeoai/eiai? o?eueo?aoe??. Aecia/aiiy oaeeeiiiai ia’?io eeoai/eiai?
o?eueo?aoe?? (OIEO) i?iaiaeeee ca e?eaith i/euaiiy e?ia? a?ae 99m-On
AeOIA, c ?aa?no?aoe??th aeoeaiino? ?cioiio ia 15-e, 24-e ? 28-e oa. Aeey
ioe?iee ie?eiaiai e?iaioieo ca ?aae?iaia?ia?aiith aeei?enoiaoaaee oae?
iieacieee: 1. *an a?oa??aeueiiai i?eieeao (Oa) – ia?ao?ae a?ae ii/aoeo
i?aeeiio e?eai? aei iaeneioio (n). 2. *an aaiiciiai a?aeoieo (Oa) – a?ae
iaeneiaeueiiai i?aeeiio e?eai? aei aeoiaeo ia ieaoi (n). 3. A?aeiinia
aaiicia ?ii?noue (A/A) – a?aeiioaiiy Oa aei Oa.

I?ney aecia/aiiy aeo?aeieo iieaciee?a ooieoe?iiaeueiiai noaio ie?ie,
iiaoi?ia aeine?aeaeaiiy i?iaiaeeee ianooiii? aeiae, /a?ac 2 aiae. i?ney
i?eeiio 25 ia eaioii?eeo – ?ia?a?oi?a AIO.

Aeey ioe?iee noaio ooieoe?? ie?ie o 60 oai?eo ia OeAe I oeio aac yaieo
ee?i?/ieo iciae AeI i?iaaaeaia iaaeeeaiaioicia i?iaa c ?iaeiiaoaoeeiii c
aecia/aiiyi oaeaeeino? eeoai/eiai? o?eueo?aoe?? ca ee??ainii
aiaeiaaiiiai e?aaoei?io. Aeey aeine?aeaeaiiy iiaeeeaino? aeei?enoaiiy
aeaiiai iaoiaeo aeey ?aiiuei? ae?aaiinoeee noaee?i?/ieo noaae?e AeI
oaeaeeinoue eeoai/eiai? o?eueo?aoe?? aecia/aee aea?/? — aei ? i?ney
i?eeiio ?iaeiiaoaoeeio, ca iaoiaeii ?aaa?aa-Oa???aa, ca ee??ainii
aiaeiaaiiiai e?aaoei?io a ia?a?aooieo ia noaiaea?oio iiaa?oith o?ea.
A?aeiia?aeue ia ?iaeiiaoaoeeiiao i?iao (?I) o?aeooaaeanue ye aaeaeaaoia
i?e cieaeaii? aeo?aeii? i?aeaeuaii? OEO aei 10 %, iaaaeaeaaoia — i?e
i?aeaeuaii? OEO aei 10 % ? a?eueoa. I?e?iaeueaoi?io??th (IAO)
ioe?ithaaee ca aeiiiiiaith oano–nioaeie o??ie Boehringer Mannheim
«Micral-Test-II» ? oano-nioaeie o??ie «Bayer» Albustix, 3-4 ?ace
i?ioyaii 2 oeaei?a.

Oai?? c aino?eie ?ioaeoe?yie na/inoaoaaiai o?aeoo, o?ii?/iith
iaaeinoaoi?noth e?iaiia?ao, caoai?thaaiiyie aaiaoia?e?a?ii? nenoaie, ui
io?eioaaee ei?oeeinoa?i?aeio oa ?ioiiaeai?aneaio oa?ai?th, oai?? c
a?oa??aeueiith a?ia?oaic??th (nenoie?/iee AO aeua 150 ii ?o no.,
na?aaei?e AO aeua 106 ii ?o. no.), ui ?ai?oa io?eioaaee a?iioaiceai?
i?aia?aoe, ?ia?a?oi?e AIO, ia aeeth/aeenue a ianoaaeaiiy c
iaaeeeaiaioiciith i?iaith ia eaioii?ee.

I?iaaaeaii aeine?aeaeaiiy ai?noo aooiaioeo?e aei AIE ie?ie ?
aecia/aiiy a e?ia? ??aiy ?ioiiaeiaoe?i?a eeano G, D, A, M o 69
oai?eo ia ?COeAe c ??cieie noaae?yie AeI.

Iayai?noue aooiaioeo?e aei AIE ie?ie o ne?iaaooe? e?ia? oai?eo
ioe?ithaaee ca i?enooiino? niaoeeo?/iiai na?o?iiy iaia?aie ie?ee iaaie
i?ney ?ieoaaoe?? noaiaea?oieo c??c?a (The Binding Site LTD, England) c
aeine?aeaeoaaiith ne?iaaoeith oai?iai ? ianooiiiai ?ioiioeoi?anoeaioiiai
caaa?aeaiiy aioeo?eaie aei ?ioiiaeiaoe?i?a ethaeeie, i?/aieo
oeoi?anoea?i?cio?ioeeiiaoii (O?OOe) (The Binding Site LTD, England).

??aaiue ?ioiiaeiaoe?i?a (Ig) eean?a G, M, A, D o ne?iaaooe? e?ia?
aecia/aee iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? ca aeiiiiiaith
noaiaea?oieo iaai??a IDP CEBAK (?anioae?ea *ao?y). Iaoiae
a?oioo?oueny ia caeaoiino? niaoeeo?/ieo aioeo?e i?e ca’ycoaaii? c
aioeaaiii ooai?thaaoe aeaeei? i/eia e?eueoey i?aoeei?oaoe?? a
aaa?iaiio aae? (Mancini G. et al., 1970).

Noaoenoe/io ia?iaeo aeaieo i?iaiaeeee iaoiaeaie aa??aoe?eii? ?
iieniai? noaoenoeee c aeiiiiiaith noaiaea?oiiai iaeaoo
noaoenoe/iiai ?ic?aooieo aeaieo Microsoft Excel ia ia?niiaeueiiio
eiii’thoa?? Pentium-233. A??ia?aei?noue ??cieoe? na?aaei?o aaee/ei
aecia/aee ca t -e?eoa???i Nouethaeaioa ? ca t-e?eoa???i O?oa?a
(aeey a?aeiinieo aaee/ei). ??cieoeth aaaaeaee a??ia?aeiith i?e ?
< 0,05; oaiaeaioe?th aei ci?ie iieaciee?a aecia/aee i?e 0,05>?<0,1, cia/aiiy ei?aeyoe?? na?aae ?yaeo iieaciee?a ?ic?aoiaoaaee ca Spearman. Iieacieee o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie o oai?eo c ii/aoeiaeie noaae?yie ae?aaaoe/ii? iao?iiao?? O ianoaaeaieo oai?eo ia aoei aeyaeaii yaieo ee?i?ei-eaai?aoi?ieo iciae o?aaeaiiy ie?ie (oaeeo ye a?oa??aeueia aeia?oaic?y, neiae?ii iaa?yeo, i?ioa?io??y). O oiae? aeine?aeaeaiiy anoaiiaeaii, ui oaea ia ?aii?o, aeiee?i?/ieo noaae?yo AeI o oai?eo ? ii?ooaiiy ooieoe?iiaeueieo iieaciee?a ie?ie, oaeeo ye /an iaeneiaeueiiai iaeiie/aiiy (Oiaen.) oa /an iai?aaeaaaeaiiy (O1/2) ?aae?ioa?ii?aia?aoo (oaae. 1). Aecia/aiiy oaeeeiiiai ia’?io eeoai/eiai? o?eueo?aoe?? ca aeiiiiiaith aeeiai?/ii? ?aiinoeeioea?ao?? aeicaieeei iai ?icae?eeoe oai?eo ia 2 a?oie a caeaaeiino? a?ae io?eiaieo ?acoeueoao?a OIEO ? ooieoe?iiaeueieo iieaciee?a ie?ie c o?aooaaiiyi IAO. Oai?? c AeI II noaae??, o yeeo na?aaei?e oaeeeii?? ia’?i eeoai/eiai? o?eueo?aoe?? aoa i?aeaeuaiee iaeaea o 1,5 ?ace ii??aiyii c ii?iith, aea i?e?iaeueaoi?io??y ia aeyaeyeany. Oai?? c AeI III noaae??, o yeeo OIEO a??ia?aeii ca?eueoeany ii??aiyii c eiio?ieai, a i?e?iaeueaoi?io??y noaiiaeea a na?aaeiueiio 200 ± 30,3 ia/aeiao. Ioaea, i?e AeI II noaae?? ??aaiue OIEO aoa aeuei, i?ae o oai?eo c AeI III noaae??. Aeey oai?eo c AeI II noaae?? oa?aeoa?iei aoei i?aeaeuaiiy OIEO o ii?aeiaii? c a?aenooi?noth IAO. O oai?eo c AeI III noaae?? iieaciee OIEO oaeiae aoa a??ia?aeii aeuei, i?ae o ii?i?, i?ioa ae?aaeai?noue oeueiai i?aeaeuaiiy aoea aeaui iaioith, i?ae o oai?eo c AeI II noaae??. Ne?ae oaeiae a?aei?oeoe a?aenooi?noue /?oei? ni?yiiaaiino? ci?i OIEO, ine?eueee aeaiee iieaciee eieeaaany o ie?aieo oai?eo a?ae iii??ii i?aeaeuaiiai aei cieaeaiiai ??aiy. A on?o 14 oai?eo aeaii? a?oie a?aei?/aeanue i?e?iaeueaoi?io??y. Iao? ?acoeueoaoe aeicaieythoue noaa?aeaeoaaoe, ui ia noaae?? IAO eeoai/eiaa o?eueo?aoe?y i?aeaeuaia iii??ii. O oai?eo c AeI II noaae?? a iaio ie?eao, /an iaeneiaeueiiai iaeiie/aiiy ?aae?ioa?ii?aia?aoo (Oiaen) a??ia?aeii oiia?eueithaaany, a /an iai?aaeaaaeaiiy ?aae?ioa?ii?aia?aoo (O1/2) aeey e?ai? ? i?aai? ie?ee ca?eueooaaany oaea?/? ii??aiyii c a?aeiia?aeiei iieacieeii o eiio?ieuei?e a?oi?. I?e AeI III noaae?? a?aei?/aia aiaeia?/ia iai?aaeaii?noue ci?i, iaeiae oiia?eueiaiiy aene?aoe?? aoei aeaui a?eueo cia/iei. A oie aea /an a??ia?aeii? ??cieoe? i?ae iieacieeaie aeaio a?oi oai?eo ia anoaiiaeaii. A?aei?/ai? ci?ie i?aeoaa?aeaeothoue aeainoi?iii?e oa?aeoa? o?aaeaiiy ie?ie i?e oeoe?iaiio ae?aaao?. Ii?ooaiiy Oiaen. ? O1/2 a iaio a?oiao oai?eo na?ae/eoue ia o?eueee i?i iaoieia?th ooieoe?iiaeueiiai noaio ie?ie, aea ? i?i eieae?caoe?th iaoieia?/iiai i?ioeano o ia?aio?i?, /aoa/eao ? ieneao ie?ie, ui ia aoei aeyaeaii i?e ee?i?ei–eaai?aoi?iiio ianoaaeaii? oai?eo. Oaeei /eiii, i?iaaaeaia ?aae?iioee?aeia ae?aaiinoeea iieaco?, ui o oai?eo ia OeAe oaea ia ?aii?o noaae?yo AeI niinoa??aathoueny ae?aaeai? ii?ooaiiy ye o?eueo?aoe?eii?, oae ? aene?aoi?ii? ooieoe?? ie?ie. I?e/iio ii?ooaiiy oe? ? ae?aci?oeie o oai?eo c AeI III noaae??, o yeeo a?aei?/aii a?eueoo o?eaae?noue ia?aa?ao caoai?thaaiiy ii??aiyii c iaoe??ioaie c AeI II noaae??. Noai ie?eiai? aaiiaeeiai?ee o oai?eo c ii/aoeiaeie noaae?yie ae?aaaoe/ii? iao?iiao?? A?aeia?aaeaiiyi a?ia?ia?ooc?? ie?ie ? iineeaiiy ie?eiaiai e?iaioieo, aeyaeaia iaie i?e ianoaaeaii? oai?eo ia ae?aaao I oeio c aeiiiiiaith iaoiaeo aeeiai?/ii? aia?ia?ao?? ie?ie i?e ?aae?i?cioiiiiio aeine?aeaeaii? c iaioaoaoii. O oai?eo ia OeAe c AeI II ? III noaae?e iai?aaeaii?noue ci?i aioo??oiueiie?eiai? aaiiaeeiai?ee aoea iaeiaeiaith: ca aeaieie iieaciee?a Oa e Oa i?eaeecii oaea?/? oiia?eueithaaeanue ye oaeaee?noue a?oa??aeueiiai i?eieeao, oae ? aaiiciiai a?aeoieo (oaae. 2). I?e oeueiio oiia?eueiaiiy aaiiciiai a?aeoieo aeaui ia?aaaaeaei iaae oiia?eueiaiiyi a?oa??aeueiiai i?eieeao ?, a?aeiia?aeii, ci?ie Oa o oai?eo ia OeAe aoee a?eueo ae?aaeai? ii??aiyii c Oa. Iaeiae iieaciee a?aeiinii? aaiicii? ?iiino? (AA?) nooo?ai ia a?ae??ciyany o caei?iaeo ? oai?eo. Iaie ia ciaeaeaii noaoenoe/ii a??ia?aeii? ??cieoe? iieaciee?a aioo??oiueiie?eiai? aaiiaeeiai?ee - a?oa??aeueiiai i?eieeao ? aaiiciiai a?aeoieo - o oai?eo c AeI II ? III noaae?e. I/aaeaeii, ii?ooaiiy aioo??oiueiie?eiai? aaiiaeeiai?ee ?icaeaathoueny oaea ia ?aii?o noaae?yo AeI ? iacia/ii i?ia?anothoue i?e ia?aoiae? iao?iiao?? ?c II a III noaae?th. Aeine?aeaeaiiy ci?i ia?oe?aeueieo ooieoe?e ie?ie i?ae aieeaii iaaeeeaiaioicii? i?iae c eaioii?eeii O aeai?e ?iaio? ie aea/aee oa?aeoa? ii?ooaiue ia?oe?aeueieo ooieoe?e ie?ie ia ?aii?o noaae?yo AeI ? ?o ci?ie i?ae aieeaii iaaeeeaiaioicii? i?iae c iaeii?aciaei i?eeiiii eaioii?eeo, a oaeiae ni?iaoaaee i?iaanoe ioe?ieo iiaeeeaino? aeei?enoaiiy oe??? oa?iaeieia?/ii? i?iae aeey ?aiiuei? ae?aaiinoeee aeiee?i?/ieo noaae?e AeI. Ianoaaeaii 24 oai?eo ia ?inoe?icaeaaeiee oeoe?iaee ae?aaao – 10 /ieia?e?a ? 14 ae?iie a?eii a?ae 18 aei 43 ?ie?a (na?aaei?e a?e 27,1 ± 1,78). O in?a eiio?ieueii? a?oie ii/aoeiaee oaeeeiiee ia’?i eeoai/eiai? o?eueo?aoe?? neeaaeaa 119,3 ± 9,2 ie/oa ? i?ney i?eeiio 25 ia eaioii?eeo ia ci?ithaaany 108 ± 11,0 ie/oa, ? > 0,5.

Ooieoe?iiaeuei? iieacieee ie?ie aei ? i?ney i?eeiio eaioii?eeo, ca
aeaieie ?aiinoeeioea?ao??, o in?a eiio?ieueii? a?oie oaeiae ia caciaaaee
nooo?aeo ci?i. Oae, Oiaen. ia eiii’thoa?ieo ?aiia?aiao aoei i?aeoe/ii
iaeiaeiaei o e?a?e ? i?aa?e ie?eao aei ? i?ney iaaeeeaiaioiciiai
iaaaioaaeaiiy a?aeiia?aeii 2,9 ± 0,6 oa, 3,0 ± 0,6 oa; ? 3,0± 0,6 oa,
3,0± 0,6 oa (? > 0,5). *an iai?aaeaaaeaiiy ?aae?i?iaeeeaoi?a ?c ie?ie
(O1/2), yeee oa?aeoa?eco? oaeaee?noue aene?aoi?ieo i?ioean?a o in?a
eiio?ieueii? a?oie aei ? i?ney eaioii?eeo ia ci?ithaaany, a?aeiia?aeii:
o e?a?e ? i?aa?e ie?eao 12 ± 2,6 oa, 10 ± 2,6 oa; ? 10,0±2,6 oa,
11,0±2,6 oa, (? > 0,5). Ca aeaieie aecia/aiiy oaeeeiiiai ia’?io
eeoai/eiai? o?eueo?aoe?? ? IAO, o an?o oai?eo anoaiiaeai? aeiee?i?/i?
noaae?? AeI. O 10 oai?eo ae?aaiinoiaaia AeI II noaae??, o 14 AeI III
noaae??.

Iaie ciaeaeaia ??cieoey a ?aaeoe?? OIEO ia eaioii?ee na?aae aeaio
aeae?eaieo a?oiao. O oai?eo c AeI II noaae?? ii/aoeiai i?aeaeuaiee OIEO,
yeee a na?aaeiueiio ii a?oi? neeaaeaa 171 ± 16,2 ie/oa, cieceany aei 134
± 8,2 ie/oa. Cieaeaiiy OIEO a?aeiia?aeaei 27,6% ? aoei noaoenoe/ii
a??ia?aeiei (? < 0,05). Iiae?aiee oei ?aaeoe?? a?aei?/aiee o 8 ?c 10 oai?eo aeaii? a?oie. A oie aea /an o oai?eo c AeI III noaae?? iaeii?aciaee i?eeii 25 ia eaioii?eeo ni?e/eiya iiaeaeueoa c?inoaiiy ii/aoeiai iii??ii i?aeaeuaiiai OIEO. I?e??no OIEO neeaaeaa 41,9%: a?ae na?aaeiueiai cia/aiiy 136 ± 9,04 ie/oa aei 193 ± 12,8 ie/oa (? < 0,01). Oaea iai?aaeai?noue ci?i OIEO niinoa??aaeanue o 10 ?c 14 oai?eo aeaii? a?oie. Oaeei /eiii, iaeii?aciaa aaaaeaiiy eaioii?eeo i?ecaiaeeei aei ??ciiiai?aaeaieo c?ooaiue iieacieea OIEO – eiai iiaeaeueoiai i?aeaeuaiiy o oai?eo c AeI III noaae?? ? cieaeaiiy o in?a c AeI II noaae??. Ia iieacieee IAO iaeii?aciaa aeica eaioii?eeo ia aieeaaea. Ca aeaieie ?aiinoeeioea?ao??, i?ney iaeii?aciaiai i?eeiio 25 ia eaioii?eeo niinoa??aaeanue iiceoeaia aeeiai?ea eiii’thoa?ieo ?aiia?ai o oai?eo iaio a?oi. I?iyaeyeinue oea iii??iei i?enei?aiiyi iieaciee?a aioo??oiueiie?eiaiai o?ainii?oo 99mOn – AeOIA, eio?? o aeo?aeiiio noai? aoee a??ia?aeii oiia?eueiai? ii??aiyii c iieacieeaie eiio?ieueieo in?a. Aaaaeaiiy eaioii?eeo aieeaaei ia iaeaeaa iieacieee – Oiaen. ? O1/2. I?e oeueiio nooi?iue ci?i /ano iaeneiaeueiiai iaeiie/aiiy ?aae?i?iae?eaoi?a ie?eith (Oiaen.) i?ae aieeaii eaioii?eeo aoa i?eaeecii iaeiaeiaei o oai?eo c AeI II ? III noaae?e, iaeiae oe? ci?ie ia aeinyaaee noaoenoe/ii? a??ia?aeiino? i?ae a?oiaie oai?eo, ? i?e ii??aiyii? ?c caei?iaeie iniaaie (P > 0,05).

Oiaen. o oai?eo c AeI II nooiaiy a?aeiia?aeii aeey e?ai? ? i?aai? ie?ee,
noaiiaea: aei i?iae — 5,0 ± 0,8 oa ? 6,0 ± 0,8 oa, i?ney — 4,1 ± 0,2 oa
? 4,3 ± 0,5 oa (P > 0,05); o oai?eo c AeI III noaae??: Oiaen. aei i?iae
— 4,9 ± 0,4 oa, ? 5,9 ± 0,8 oa, i?ney 4,1 ± 0,4 oa, ? 4,7 ± 0,9 oa (P >
0,05).

Aeayea iiceoeaia aeeiai?ea niinoa??aaeanue c aieo /ano
iai?aaeaaaeaiiy (O1/2)

99m On-AeOIA ?c ie?ie. Oea ae?aaeaeinue o ciaioaii? iieacieea O1/2 ye
iciaee i?enei?aiiy aene?aoi?ii? ooieoe??. Ia?a?nii cia/ii niia?eueiaiee
/an iai?aaeaaaeaiiy O1/2 ?c ie?ie o iaoe??io?a iaio ee?i?/ieo a?oi i?ney
i?eeiio eaioii?eeo iii??ii i?enei?thaaany. Iaeiae, ye ? ?ai?oa,
caa??aaeanue nooo?aa noaoenoe/ii cia/eia ??cieoey c ii?iith (P < 0,05), i?e/iio a?eueo aeaiiino?aoeaia, i?ae aeey iieacieea Oiaen. O oai?eo c AeI II noaae?? O1/2, i?ney aaaaeaiiy eaioii?eeo iaeaea ia ci?ieany (aei i?eeiio i?aia?aoo - 29,7 ± 4,1 oa ? 26,4 ± 4,2 oa, i?ney - 24,8 ± 4,1 oa ? 25,6 ± 3,6 oa, (P > 0,05); o oai?eo c AeI III noaae??
O1/2 a?aeiia?aeii aeey e?ai? ? i?aai? ie?ee i?ney eaioii?eeo iacia/ii
ciaioeany ( c 32,8 ± 3,9 oa ? 32,6 ± 4,2 oa aei 27,0 ± 4,1 oa ? 28,8 ±
4,0 oa, (P > 0,05).

Iaie i?inoaaeaia oaeiae ?aaeoe?y c aieo iieaciee?a ie?eiai?
aaiiaeeiai?ee ca aeaieie ?aae?iioee?aeii? aia?ia?ao?? ia iaeii?aciaee
i?eeii 25 ia eaioii?eeo o in?a eiio?ieueii? a?oie ? o oai?eo c AeI II ?
III noaae?e. sse iieaco? aiae?c, ia oe? iaaeeeaiaioiciiai iaaaioaaeaiiy
ia aeyaeaii nooo?aeo ci?i iieaciee?a a?oa??aeueiiai i?eieeao ? aaiiciiai
a?aeoieo o in?a eiio?ieueii? a?oie. Iieacieee — Oa, Oa ? AA? caeeoaeenue
o iaaeao ii?iaeueieo aaee/ei.

*an a?oa??aeueiiai i?eieeao (Oa) aeey e?ai? ? i?aai? ie?ee o oai?eo c
AeI II noaae?? i?ney aaaaeaiiy eaioii?eeo ia ci?ithaaany (aei — 15,2 ±
1,4 n. ? 15,1 ± 1,3 n, i?ney — 13,1 ± 0,5 n ? 13,4 ± 0,4 nae, (P >
0,05); o oai?eo c AeI III noaae??, a?aeiia?aeii noaiiaea: aei — 18,8 ±
1,5 n ? 18,6 ± 1,3 n, i?ney — 14,5 ± 1,2 n ? 14,8 ± 1,6n, (P > 0,05);
i?e cia/aii? aeaiiai iieacieea o eiio?ieuei?e a?oi? aeey e?ai? ? i?aai?
ie?ee — 9,0± 0,5 n ? 8,1 ± 0,4 n, (P < 0,05). Iieaciee aaiicii? oace (Oa) aoa aeinoaoiuei ?acenoaioiei aei aeei?enoaii? aeice eaioii?eeo ? a??ia?aeii ia a?ae??ciyany a?ae ii/aoeiaiai cia/aiiy (P > 0,5) a iaio a?oiao oai?eo, caeeoath/enue
nooo?ai oiia?eueiaiei ii??aiyii c ii?iith (P < 0,05). Oae, o a?oi? oai?eo c AeI II noaae??, a?aeiia?aeii aeey e?ai? ? i?aai? ie?ee, Oa aei i?eeiio eaioii?eeo noaiiaea 12,6 ± 1,4 n ? 12,2 ± 1,8 n, i?ney 14,5 ± 0,4 n ? 14,7 ± 0,6 n, (P > 0,5); i?e cia/aii? aeaiiai iieacieea o
eiio?ieuei?e a?oi? aeey e?ai? ? i?aai? ie?ee 6,7± 0,3 n ? 6,4 ± 0,4 n,
(P < 0,05). O oai?eo c AeI III noaae?? niinoa??aaeanue oaea ae neooaoe?y: Oa aei i?eeiio eaioii?eeo coaiiaea - 13,8 ± 1 ,4 n ? 13,5 ± 1,5 n, i?ney - 14,4 ± 0,8 n ? 14,5 ± 0,15 n, (P > 0,5). Iaaiith i??ith
oea iiaea aooe ca’ycaii c oei, ui o /anoeie oai?eo iaio a?oi i?e
ia?aeiiiio ianoaaeaii? a?aei?/aeinue ??cea ii?ooaiiy aaiiciiai a?aeoieo
o aeaeyae? aaiiciiai noaca.

Noai ie?eiai? aaiiaeeiai?ee, ui niinoa??aaany o a?oi? oai?eo c AeI II
noaae??, noi?iaiaeaeoaaany i?aeaeuaiiyi AA?, a?aeiia?aeii a e?a?e ?
i?aa?e ie?oe?: aei eaioii?eeo — 0,84 ± 0,09 ? 0,82 ± 0,07, i?ney — 1,1 ±
0,03 ? 1,2 ± 0,05, i?ioa oe? ci?ie ia aoee a??ia?aeieie (P > 0,05).
Aiaeia?/ia ea?oeia AA? a?aecia/aeany o oai?eo c AeI III noaae??. AA? o
e?a?e ? i?aa?e ie?oe? aei i?eeiio eaioii?eeo neeaea 0,86 ± 0,14 ? 0,86 ±
0,12, i?ney — 0,98 ± 0,14 ? 0,97 ± 0,12 (P>0,2), oiaoi i?ae aieeaii
eaioii?eeo AA? ia ci?ieeanue. Oaeei /eiii, ye iieacaee i?iaaaeai?
aeine?aeaeaiiy, eaioii?ee ia? ae?aaeaiee aieea ia ooieoe?iiaeuei?
iieacieee ie?ie o oai?eo c AeI: cieaeo? ii/aoeiai cia/ii i?aeaeuaiee
OIEO o oai?eo c AeI II noaae?? ? ca?eueoo? iii??ii i?aeaeuaiee OIEO o
oai?eo c AeI III noaae??. Iiaeia i?eionoeoe, ui a?eueo ?aii? ci?ie
ooieoe?iiaeueieo iieaciee?a ie?ie, ui i?iyaeythoueny o aeaeyae? AeI II
noaae??, a?eueo /ooeea? aei ii?iae?coth/i? ae?? eaioii?eeo ii??aiyii c?
ci?iaie o oai?eo c a?eueo ae?aaeaiith AeI III noaae??. Ia aeeaey/enue ia
a oe?eiio iiceoeaio iai?aaeaii?noue, ci?ie iieaciee?a
aioo??oiueiie?eiaiai o?ainii?oo ? ie?eiai? aaiiaeeiai?ee caeeoaeenue
ii?ooaieie ? ia ei?aaoaaeenue iiai?noth iaeii?aciaei i?eeiiii
eaioii?eeo.

Io?eiai? iaie ?acoeueoaoe na?ae/aoue i?i oa, ui aeei?enoaiiy
eaioii?eeiai? i?iae c iaeii?aciaei i?eeiiii 25ia i?aia?aoo, aeicaiey?
aaeaeaaoii ioe?ieoe noai aeiia?oey?ii? aaiiaeeiai?ee, ?? ?aaeoeai?noue
ia ??cieo noaae?yo AeI. Iaeiae aiia iaaeinoaoiuei /ooeeaa aeey
aeeoa?aioe?aoe?? AeI II ? III noaae?e. A oie aea /an eaioii?eeiaa i?iaa
?ioi?iaoeaia o oai?eo ia aeiee?i?/ieo noaae?yo AeI o ieai? i?iaiicoaaiiy
?? iiceoeaiiai aieeao ia ia?oe?aeuei? ooieoe?? ie?ie, cie?aia OIEO, ?
a?aeai?o oai?eo aeey e?eoaaiiy eaioii?eeii.

Aieea iaaeeeaiaioicii? i?iae c ?iaeiiaoaoeeiii ia oaeaee?noue
eeoai/eiai? o?eueo?aoe??

I?e i?iaaaeaii? iaaeeeaiaioicii? i?iae c ?iaeiiaoaoeeiii iaie
a?aei?/aii, ui o a?oi? iaoe??io?a aac AeI aaaaeaiiy i?aia?aoo
i?enei?thaaei OEO, yea, iaeiae caeeoaeanue o iaaeao ii?iaeueieo aaee/ei
— 80 ± 2,3 ie/oa ? 103 ± 2,2 ie/oa (P<0,05), aei ? i?ney ?iaeiiaoaoeeio, a?aeiia?aeii. Ioaea, ?iaeiiaoaoeei iiaea aieeaaoe ia ii?iaeueio OEO o oai?eo ia OeAe aac AeI, oi/a aiia caeeoa?oueny o iaaeao aeiionoeieo ii?iaeueieo eieeaaiue. Ca oiiae oa?iaeieia?/iiai iaaaioaaeaiiy ?iaeiiaoaoeeiii o oai?eo c AeI II ? III noaae?? iaie ciaeaeaii iaiaeii??aeiee oa?aeoa? ci?i OEO i?ae aieeaii i?eeiio i?aia?aoo. Oae, na?aae iaoe??io?a c AeI ?? noaae?? o 16 ?c 24 (66,7%) i?ney ?iaeiiaoaoeeia aecia/aeinue i?aeaeuaiiy OEO ia 15,6% (a?ae 160 ± 2,3 ie/oa aei 185 ± 2,7 ie/oa, ? < 0,001); o 8 iaoe??io?a (33,3%) ca oeo aea ianoaaeaieo a?aei?/aii cieaeaiiy OEO ia 13,4 % (a?ae 171 ± 2,5 ie/oa aei 148 ±2,5 ie/oa, ? < 0,001). Na?aae oai?eo c AeI ??? noaae?? o 14 ?c 25 (56%) o a?aeiia?aeue ia ?iaeiiaoaoeei aeyaeaia c?inoaiiy ii/aoeiai i?aeaeuaii? OEO ia 19,4% - a?ae 141 ± 2,5 ie/oa aei 175 ± 2,7 ie/oa (? < 0,05). O oeeo iaoe??io?a aaaaeaiiy ?iaeiiaoaoeeio i?ecaiaeeei aei i?aeaeuaiiy aene?aoe?? aeueaoi?io c na/ath. Aei ? i?ney i?ecia/aiiy ?iaeiiaoaoeeia IAO neeaaeaei 100 ± 30,5 ia/aeiao ? 300 ± 30,0 ia/aeiao, a?aeiia?aeii (? < 0,01). O oe?e aea a?oi? o 11 (44 %) oai?eo ia ae?aaao i?ney i?eeiio ?iaeiiaoaoeeio aoei aeyaeaii cieaeaiiy ii/aoeiai i?aeaeuaii? OEO ia 10,5% - a?ae 152 ± 2,5 ie/oa aei 136 ± 2,5 ie/oa (? < 0,01); a?aei?/aeinue cia/ia cieaeaiiiy IAO (ia 93,3%), o na?aaeiueiio a?ae 300 ± 30,5 ia/aeiao aei 100 ± 20,0 ia/aeiao (? < 0,05). Oaeei /eiii, o a?eueoino? oai?eo c ?aii?ie noaee?i?/ieie noaae?yie AeI niinoa??aa?oueny i?aeaeuaiiy OEO o a?aeiia?aeue ia i?eeii ?iaeiiaoaoeeio. Ie i?eionea?ii, ui o oaeeo oai?eo c i?aeaeuaiiyi OEO ? c?inoaiiyi IAO o a?aeiia?aeue ia i?iao c eiaeiiaoaoeeiii aeoeai?noue aeai?ani?ii? ai?iiiaeueii? nenoaie ie?ie ??cei ia?aaaaea? iaae i?ani?iith, ui iiaea iaoiiaethaaoe no?eeo a?ia?o?eueo?aoe?th ? a?ia?ia?ooc?th ie?ie. Ai?no aioeo?e aei aacaeueii? iaia?aie eeoai/e?a ie?ie oa ?ioiiaeiaoe?i?a o ne?iaaooe? e?ia? oai?eo c ??cieie noaae?yie ae?aaaoe/ii? iao?iiao?? Iaie i?iaaaeaii aea/aiiy oa?aeoa?o ci?i ??aiy oee?eoethth/eo ?ioiiaeiaoe?i?a ? i?iaeoeoe?? aooiaioeo?e aei aacaeueii? iaia?aie eeoai/e?a ie?ie o oai?eo ia ?COeAe c ??cieie noaae?yie AeI. Ianoaaeaii 69 oai?eo - /ieia?/i? (41%) ? ae?ii/i? (59%) noao? a?eii a?ae 16 aei 50 ?ie?a (na?aaei?e a?e 28,6 + 1,3 ?ie?a) c o?eaae?noth caoai?thaaiiy a?ae 1 i?n aei 38 ?ie?a (a na?aaeiueiio 12,6 +1,1 ?ie?a). An? iaoe??ioe ciaoiaeeeenue o noai? eiiiainaoe?? ? noaeiiiainaoe?? caoai?thaaiiy. O eiio?ieuei?e a?oi? ianoaaeoaaieo in?a ia aoei ciaeaeaii aooiaioeo?e aei AIE ie?ee, a ??aaiue Ig eean?a G, M, A, D neeaaeaa 1635 + 46 ia/aee, 305 + 31 ia/aee, 158 + 11 ia/aee, 23,2 + 0,4 ia/aee, a?aeiia?aeii. O a?oi? oai?eo ia ?COeAe aoei aeyaeaii 6 in?a c aenieith eiioeaio?aoe??th aooiaioeo?e aei AIE (ui ae?aaeaeinue o aeaeyae? yne?aaiai na?/aiiy iioa?aiaaieo c??c?a) ? 9 in?a c iaaenieith eiioeaio?aoe??th aooiaioeo?e (neaaea na?/aiiy). Ca iaoeie aeaieie, /enei oai?eo c iiceoeaiith ?aaeoe??th ia iayai?noue aooiaioeo?e aei AIE c?inoa? ?c iineeaiiyi ae?aaeaiino? ee?i?/ieo i?iya?a AeI. I?e oeueiio o a?eueoi? /anoeie iaoe??io?a c iiceoeaiith ?aaeoe??th ia aioeo?ea aoea ae?aaiinoiaaia III-IV noaae?y ?icaeoeo AeI. Ie i?eionea?ii, ui iiyaa aooiaioeo?e aei AIE i?e oeoe?iaiio ae?aaao? ? aoi?eiiei oaiiiaiii, ui ?icaeaa?oueny o a?aeiia?aeue ia iaoaaie?/i? ? no?oeoo?i? ci?ie ie?eiai? oeaieie. A oie aea /an, o iaoiio aeine?aeaeaii? i?e ?iciiae?e? iaoe??io?a c ?COeAe ia a?oie c ? aac iayaiino? aooiaioeo?e aei AIE aeaeii, ui o oai?eo c o?eaaeei o oeaieiao ie?ee aooi?ioiiei i?ioeanii i?aeaeuo?oueny eiioeaio?aoe?y aioeo?e eean?a IgG (1688,7 ± 111,2 ia/aee ? 1270,8 ± 52,3 ia/aee, a?aeiia?aeii, P<0,001,) ? IgM (288,9 ± 22,8 ia/aee ? 192,1 ± 14,1 ia/aee, a?aeiia?aeii, P<0,001) ? iacia/ii cieaeo?oueny eiioeaio?aoe?y aioeo?e eeano IgA (122,1 ± 8,9 ? 140,7 ± 6,8 ia/aee, P<0,01 a?aeiia?aeii). Ca?aeii c aeaieie A.A. Aaeaiie oa ?i. (1998), aeao?oeeo IgA ca’ycaiee c aa?aneaiei ia?aa?aii aooi?ioiieo caoai?thaaiue, a oiio /ene? ?COeAe. Ca aeaieie oeeo aeine?aeaeaiue, cieaeaiee ??aaiue IgA /ano?oa niinoa??aa?oueny ia aoaiao caoai?thaaiiy, eiee aooi?ioiiee i?ioean iaea?eueo aeoeaiee, ui iiai?noth ocaiaeaeo?oueny ?c iaoeie aeaieie, ui aeyaeee ciaioaiiy ai?noo IgA o oai?eo c iiceoeaiith ?aaeoe??th ia aioeo?ea aei AIE. Aeey anoaiiaeaiiy a?eueo ?ioi?iaoeaiiai ia?ea?a ?nioaaiiy aooi?ioiiiai i?ioeano o oai?eo ia ?COeAe ie i?iaiae?coaaee iieaciee ia o?eueee aaniethoiiai ai?noo ?ioiiaeiaoe?i?a, aea ? ?o ni?aa?aeiioaiiy o ne?iaaooe? e?ia?. O iaoe??io?a c aeyaeaieie aioeo?eaie aei AIE, ii??aiyii c iieacieeaie oai?eo c iaaaoeaiith ?aaeoe??th ia iayai?noue aioeo?e aei AIE, a??ia?aeii i?aeaeuai? iieacieee ni?aa?aeiioaiiy eiioeaio?aoe?? ?ioiiaeiaoe?i?a eean?a IgG/IgD (88,9 ± 6,3 ? 69,0 ± 2,8 ia/aee, a?aeiia?aeii) ? IgM/IgD (15,5 ± 1,5 ? 10,9 ± 0,9 ia/aee, a?aeiia?aeii) ? cieaeai? iieacieee ni?aa?aeiioaiiy eiioeaio?aoe?e ?ioiiaeiaoe?i?a IgA/IgG (0,076 ± 0,006 ? 0,115 ± 0,006 ia/aee, a?aeiia?aeii ia/aee) ? IgA/IgM (0,457 ± 0,054 ? 0,894 ± 0,070 ia/aee, a?aeiia?aeii). Ia i?aenoaa? io?eiaieo aeaieo ie i?eeoee aei aeniiaeo, ui ni?aa?aeiioaiiy i?ae eiioeaio?aoe?yie ?ioiiaeiaoe?i?a eean?a IgG/IgD ? IgA/IgG o ne?iaaooe? e?ia? oai?eo ?COeAe iiaeia aaaaeaoe ia?ea?aie ia?aa?ao aooi?ioiiiai i?ioeano o oeaieiao ie?ie. I?e aiae?c? ci?i eiioeaio?aoe?e ?ioiiaeiaoe?i?a o ne?iaaooe? e?ia? iaoe??io?a c ??ciei nooiaiai AeI a??ia?aeii? ??cieoe? aeyaeoe ia aaeaeiny. ??aaiue IgG aoa iaeneiaeueiei ia ii/aoeiaeo noaae?yo ?COeAe (aac aeyaeaii? AeI), neeaaeath/e o n?aaeiueiio 1408,3 ± 91,4 ia/aee, iio?i iinooiiai cieaeoaaany aei 1217,5 ± 280,6 ia/aee, a ??aaiue IgI iaa oaiaeaioe?th aei i?aeaeuaiiy, nyaath/e iaea?eueoeo cia/aiue o oai?eo c ae?aaeaiith iao?iiao??th. Ine?eueee o ia?aeii?e ?ioii?e a?aeiia?ae? aa?a o/anoue IgI, oi i?e oi?ioaaii? ? i?ia?anoaaii? AeI iiaea niinoa??aaoenue iaaeeeoeiaa nae?aoe?y aioeo?e naia oeueiai eeano. O aoi?eii?e ?ioii?e a?aeiia?ae? aaeeea cia/aiiy iathoue IgG, ye?, ca’ycoth/enue c iiaeeo?eiaaieie e?i?aeaie, ni?eythoue ooai?aiith oee?eoethth/eo ?ioiieo eiiieaen?a, i?e oeueiio ??aaiue aioeo?e eeano IgG o ne?iaaooe? iiaea cieaeoaaoeny. Oaeei /eiii, ?acoeueoaoe aeanieo aeine?aeaeaiue ? aeai? e?oa?aoo?e aeicaieythoue noaa?aeaeoaaoe, ui aioeo?ea aei ie?eiaeo no?oeoo? (AIE) oae naii, ye ? ?io? aioeo?ea, ni?iiiaei? a?aoe o/anoue a ooai?aii? oee?eoethth/eo ?ioiieo eiiieaen?a, ie??i oiai, iath/e iioaioe?eio aeanio iao?ioiene/i?noue, iiaeooue i?iyaeyoe aaciina?aeiuei ooeiaeaeoth/o ae?th. O/anoue ?ioiiiai iaoai?cio o oi?ioaaii? o?aaeaiiy ie?ie i?e OeAe I oeio, i/aaeaeii, i?iyaey?oueny o a?eueo ?aii? no?iee, i?ae i?e OeAe II oeio, ine?eueee iai?oanoaoe?? OeAe I oeio i?eoaiaiia ?ioiia, a a?aeoae ? aooi?ioiia aa?an?y, iaoe?eaia ia ino??aoeaaee aia?ao i?aeoeoieiai? caeice. C ia?inoaiiyi iaoaaie?/ieo ii?ooaiue ae??oaeueio ?ieue ii/eiathoue a?ae?a?aaaoe aooi?ioii? ?aaeoe??, oae ye ci?ie no?oeoo?e i?aai?a noathoue aooiaioeaaiaie. AENIIAEE 1. Ca aeaieie aeeiai?/ii? ?aiinoeeioea?ao??, ?aii?i i?iyaii iao?iiao?? o oai?eo ia ? oei oeoe?iaiai ae?aaaoo ? ii?ooaiiy o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie, ui i?iyaeythoueny a?aeoeeaiyie iieaciee?a oaeeeiiiai ia’?io eeoai/eiai? o?eueo?aoe??, /ano iaeneiaeueiiai iaeiie/aiiy, /ano iai?aaeaaaeaiiy ?aae?ioa?ii?aia?aoo; a?aeoeeaiiy iathoue aeaicoi?iii?e oa?aeoa? ? aeyaeythoueny ua i?e a?aenooiino? i?e?iaeueaoi?io???. 2. O oai?eo ia ?inoe?icaeaaeiee oeoe?iaee ae?aaao c aeiee?i?/ieie noaae?yie ae?aaaoe/ii? iao?iiao?? a?aei?/athoueny ii?ooaiiy ie?eiai? aaiiaeeiai?ee o aeaeyae? ciaioaiiy oaeaeeino? ie?eiaiai e?iaioieo ? cieaeaiiy a?aeiinii? aaiicii? ?iiino? ie?ie. 3. Ci?ie ia?aiao??a ie?eiai? aaiiaeeiai?ee o a?aeiia?aeue ia aaaaeaiiy eaioii?eeo caeaaeaoue a?ae noaae?? ae?aaaoe/ii? iao?iiao?? ? iiaeooue a?aeia?aaeaoe ?aaeoeai?noue aeiia?oey?ii? aaiiaeeiai?ee. 4. Iaeii?aciaa i?ecia/aiiy ?ia?a?oi?a aia?ioaiceiia?aoai?thth/iai oa?iaioo eaioii?eeo i?ecaiaeeoue aei ii?iae?caoe?? ii?ooaieo aaiiaeeiai?/ieo iieaciee?a ie?ie o oai?eo c AeI II ? III noaae??. 5. Aaaaeaiiy i?aia?aoo ?ia?a?oi?a neioaco i?inoaaeaiaeei?a – ?iaeiiaoaoeeio noi?iaiaeaeo?oueny cieaeaiiyi ii/aoeiai i?aeaeuaii? oaeaeeino? eeoai/eiai? o?eueo?aoe??. Aeey a?eueoino? oai?eo ia ae?aaao c ?aii?ie i?iyaaie iao?iiao?? oa?aeoa?iei ? ii?ooaiiy aaeaeaaoii? ?aaeoe?? ia ?iaeiiaoaoeei, ui i?iyaey?oueny iiaeaeueoei c?inoaiiyi oaeaeeino? eeoai/eiai? o?eueo?aoe??. 6. O 26,8% oai?eo ia ?inoeeicaeaaeiee oeoe?iaee ae?aaao aecia/a?oueny iayai?noue aioeo?e aei aacaeueii? iaia?aie eeoai/e?a ie?ie, i?e/iio /enei oai?eo c iiceoeaiith ?aaeoe??th ia iayai?noue aioeo?e c?inoa? o i??o i?ia?anoaaiiy iao?iiao??, ui iiaea na?ae/eoe i?i o/anoue aooi?ioiieo iaoai?ci?a o ?icaeoeo ? i?ia?anoaaii? ae?aaaoe/ii? iao?iiao??. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeeiai?/ia ?aiinoeeioea?ao?y iiaea aeei?enoiaoaaoeny aeey aeyaeaiiy ?aii?o noaee?i?/ieo noaae?e ae?aaaoe/ii? iao?iiao?? o in?a c ? oeiii oeoe?iaiai ae?aaaoo. 2. Iai?yia aia?ia?ao?y ?aeiiaiaeo?oueny ye ?ioi?iaoeaiee iaoiae aeyaeaiiy ii?ooaiiy ie?eiai? aaiiaeeiai?ee o oai?eo ia oeoe?iaee ae?aaao aac ee?i?/ii ae?aaeaii? ae?aaaoe/ii? iao?iiao??. 3. Aeei?enoaiiy iaaeeeaiaioicii? i?iae c iaeii?aciaei aaaaeaiiyi ?ia?a?oi?a aia?ioaiceiia?aoai?thth/iai oa?iaioo – eaioii?eeo aeicaiey? ioe?ieoe ?aaeoeai?noue ie?eiai? aaiiaeeiai?ee ia ?aii?o noaae?yo ae?aaaoe/ii? iao?iiao?? ? iiaea aooe ei?eniei aeey aiae?co aoaeoeaiino? o?eaaei? oa?ai?? ?ia?a?oi?aie AIO. 4. ??ciiiai?aaeai? ?aaeoe?? ia aaaaeaiiy ?ia?a?oi?o neioaca i?inoaaeaiaeei?a – eiaeiiaoaoeeio, ye? i?iyaeythoueny o a?eueoino? oai?eo iiaeaeueoei i?aeaeuaiiyi OIEO, a o ?ioeo – cieaeaiiyi OIEO, aeicaieythoue aeyaeoe ?iaeea?aeoaeuei? ?aaeoe?? oai?eo ia i?aia?ao ? ?aeiiaiaeoaaoe ?iaeiiaoaoeei aeey e?eoaaiiy noaee?i?/ieo noaae?e ae?aaaoe/ii? iao?iiao?? o oai?eo c aaeaeaaoiith ?aaeoe??th. Nienie ?ia?o, ui iioae?eiaai? ca oaiith aeena?oaoe??: 1. Oaaeaeeaaa Ae. *. Aeeaaaoe/aneay iao?iiaoey: ea/aiea e i?ioeeaeoeea // I?iaeaie yeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Na. Eoaaineiai iaae. ei-oa. Aei. 5. - 1998. - N. 5-7. 2. Oaaeaeeaaa Ae. *. I iaeioi?uo iaoaieciao aeeaaaoe/aneie iao?iiaoee e aa ?aiiae aeeaaiinoeea // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Na. Eoaaineiai iaae. ei-oa. Aei. 6. - 1998. - N. 10-12. 3. Oaaeae?aaa Ae. *., O?iiueei I.Ae., Neaaiia A.I., ?o?iia A.N. Aeeiai?/ia ?aiinoeeioea?ao?y oa ?aae?iioee?aeia aia?ia?ao?y ie?ie c eaioii?eeii a ae?aaiinoeoe? aeiee?i?/ieo oi?i ae?aaaoe/ii? iao?iiao?? // Oe?a?ineee ?aae?ieia?/iee aeo?iae.- 1999.- ? 3.- N. 318-321. 4. Aoeiia A.N., Iaiueeianeee A. I., Oaaeaeeaaa Ae. *. Nia?aiaiiua i?aaenoaaeaiey i iaoaieciao ?acaeoey aeeaaaoe/aneeo iao?iiaoee (iaci? eeoa?aoo?u e nianoaaiiua aeaiiua) // Aiaeie?eiieia?y.-1999.- O.4, ? 1. - N. 71-85. 5. Iaiueeianeee A. I., Oaaeaeeaaa Ae. *. Iaaeeeaiaioiciay i?iaa n eiaeiiaoaoeeiii a aeeaaiinoeea noaeeeie/aneeo oi?i aeeaaaoe/aneie iao?iiaoee. // E?ea?nueea ni?aaa. - 1999. - o. 1044, ? 2.- N.83-87. 6. Tronko N.D., Tadjieva J.Ch., Naumenko V.G. Medicamentous test with captopril for diagnostics of early stages of diabetic nephropathy // Diabetologia polska. - 1999. - Vol. 6. - Suppl.1. - P. 49. 7. Tadjieva J. and Mankovsky B. N. Antibodies to kidney's basal membrane in patients with different stages of diabetic nephropathy // Diabetologia. – 1999. – Vol. 42. - Suppl.1. - P. 29 AIIOAOe?ss Oaaeaee?aa I. *. "?aiiy ae?aaiinoeea ae?aaaoe/ii? iao?iiao?? o oai?eo ia ?inoe?icaeaaeiee oeoe?iaee ae?aaao". - ?oeiien. Aeena?oaoe?y ia caeiaoooy o/aiiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14. 01. 14. – aiaeie?eiieia?y. ?inoeooo aiaeie?eiieia?? oa iai?io ?a/iaei ?i. A. I. Eii?na?aiea AII Oe?a?ie, Ee?a, 1999. I?iaaaeaii aeine?aeaeaiiy ci?i o?eueo?aoe?eii-aene?aoi?ii? ooieoe?? ie?ie, ie?eiai? aaiiaeeiai?ee, ye? i?iyaeythoueny ye ??ciiiai?aaeai? ci?ie oaeeeiiiai ia’?io eeoai/eiai? o?eueo?aoe??, /ano iaeneiaeueiiai iaeiie/aiiy, /ano iai?aaeaaaeaiiy ?aae?ioa?ii?aia?aoo, ciaioaiiy oaeaeeino? ie?eiaiai e?iaiieeio ? a?aeiinii? aaiicii? ?iiino? ie?ie o oai?eo c aeiee?i?/ieie noaae?yie ae?aaaoe/ii? iao?iiao??. Ia oe? iaaeeeaiaioicieo i?ia c ?ia?a?oi?ii aia?ioaiceiia?aoai?thth/iai oa?iaioo – eaioii?eeii, ianoa?i?aeiei i?ioecaiaeueiei i?aia?aoii – ?iaeiiaoaoeeiii, aea/aii oa?aeoa? ci?i ia?oe?aeueieo ooieoe?e ? aaiiaeeiai?/ieo iieaciee?a ie?ie ia ?aii?o noaae?yo ?acaeoeo ae?aaaoe/ii? iao?iiao?? o oai?eo ia I oei oeoe?iaiai ae?aaaoo. Iieacaii, ui aeey a?eueoino? oai?eo ia oeoe?iaee ae?aaao I oeio, c iciaeaie ii/aoeiai? iao?iiao?? oa?aeoa?iei ? ia?ae?o/aiiy aaeaeaaoii? ?aaeoe?? ia ?iaeiiaoaoeei, ui i?iyaey?oueny o iiaeaeueoiio c?inoaii? oaeaeeino? eeoai/eiai? o?eueo?aoe??, i?e/iio oe? c?ooaiiy ?acaeaathoueny ia ?aii?o noaae?yo iao?iiao??. Anoaiiaeaii, ui ci?ie ia?aiao??a ie?eiai? aaiiaeeiai?ee o a?aeiia?aeue ia aaaaeaiiy eaioii?eeo caeaaeaoue a?ae noaae?? ae?aaaoe/ii? iao?iiao?? ? iiaeooue a?aeia?aaeaoe ?aaeoeai?noue aeiia?oey?ii? aaiiaeeiai?ee. Ioa?aeoa?eciaaiee noai aoii?aeueiiai ?ioi?oaoo, aeyaeai? iniaeeaino? i?iaeoeoe?? ?ioiiaeiaoe?i?a ??cieo eean?a, aioeo?e aei aacaeueieo iaia?ai eeoai/e?a ie?ie o oai?eo c ??ciiiai?oieie, a oiio /ene? aeiee?i?/ieie, noaae?yie ae?aaaoe/ii? iao?iiao??. A ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue, iiaeeaeaii oyaeaiiy i?i iaoio?c?ieia?/i? iaoai?cie oi?ioaaiiy ?aii?o noaae?e o?aaeaiiy ie?ie o oai?eo ia ?COeAe. ?ic?iaeai? i?aeoiaee aei ae?aaiinoeee ?aii?o noaae?e ae?aaaoe/ii? iao?iiao??. Eeth/ia? neiaa: ae?aaaoe/ia iao?iiao?y, oaeaee?noue eeoai/eiai? o?eueo?aoe??, i?e?iaeueaoi?io??y, aioeo?ea aei aacaeueieo iaia?ai eeoai/e?a ie?ie, ?ioiiaeiaoe?ie. AIIIOAOeEss Oaaeaeeaaa I. *. "?aiiyy aeeaaiinoeea aeeaaaoe/aneeo iao?iiaoee o aieueiuo n einoeeicaaeneiui naoa?iui aeeaaaoii". - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14. 01. 14. – yiaeie?eiieiaey. Einoeooo yiaeie?eiieiaee e iaiaia aauanoa ei. A. I. Eiienna?aiei, Eeaa, 1999. I?iaaaeaii ii?aaeaeaiea oeeueo?aoeeiiii-yene?aoi?iie ooieoeee ii/ae i?e iiiiue aeeiaie/aneie ?aiinoeeioea?aoee n 99mOn-AeOIA, o aieueiuo n I oeiii naoa?iiai aeeaaaoa. I?e yoii auyaeaii, /oi o aieueiuo oaea ia ?aiiae, aeieeeie/aneie noaaeee aeeaaaoe/aneie iao?iiaoee eiathony ia?ooaiey ooieoeeiiaeueiuo iieacaoaeae ii/ae oaeeo eae, eiaeaen iaeiieaiey, a?aiy iieoauaaaeaiey, yene?aoi?iue eiaeaen, a?aiy iaeneiaeueiiai iaeiieaiey ?aaeeioa?ii?aia?aoa. Iaeaieaa oa?aeoa?iuie eciaiaieyie aeey aieueiuo n aeeaaaoe/aneie iao?iiaoeae II e III noaaeee auee caiaaeeaiea eiaeaena iaeiieaiey, auaaaeaiey ecioiia ec ii/ae, /oi i?iyaeyeinue oaeeeiaieai ia?eiaea iieoauaaaeaiey i?aia?aoa ii n?aaiaieth n iieacaoaeyie eiio?ieueiie a?oiiu. Iieo/aiiua aeaiiua iicaieytho ooaa?aeaeaoue, /oi eciaiaiey oeeueo?aoeeiiii-yene?aoi?iie ooieoeee ii/ae ?acaeaathony oaea ia ?aiieo noaaeeyo ?acaeoey aeeaaaoe/aneie iao?iiaoee, aua aei iiyaeaiey iee?iaeueaoieio?ee, o eeoe n aeeaaaoe/aneie iao?iiaoeae II noaaeee. Iaeiaei, iineieueeo ia?ooaiea ia?a/eneaiiuo iieacaoaeae auee aieueoa au?aaeaiu o aieueiuo n III noaaeeae aeeaaaoe/aneie iao?iiaoee, o eioi?uo ioia/aeanue oaeaea aieueoay aeeeoaeueiinoue oa/aiey naoa?iiai aeeaaaoa, iiaeii i?aaeiieaaaoue, /oi auyaeaiiua ia?ooaiey i?ia?anne?otho ii ia?a oaaee/aiey n?iea oa/aiey aeeaaaoa e i?ia?anne?iaaiey iao?iiaoee. Enneaaeiaaiu eciaiaiey oeeueo?aoeeiiii-yene?aoi?iie ooieoeee ii/ae, ii/a/iie aaiiaeeiaieee, eioi?ua i?iyaeythony a aeaea ?aciiiai?aaeaiiuo eciaiaiee ieiooiiai iauaia eeoai/eiaie oeeueo?aoeee, oiaiueoaiey nei?inoe ii/a/iiai e?iaioiea e ioiineoaeueiie aaiiciie aieinoe ii/ae o aieueiuo n aeieeeie/aneeie noaaeeyie aeeaaaoe/aneie iao?iiaoee. O aieueiuo n aeeaaaoe/aneie iao?iiaoeae II noaaeee e III noaaeee auei ca?aaeno?e?iaaii iiauoaiea a?oa?eaeueiiai i?eoiea, e caiaaeeaiea aaiiciiai iooiea. I?e yoii neaaeoao iiae/a?eiooue, /oi ia?ooaiey aaiiciiai e?iaioiea i?ia?anne?iaaee ii ia?a ia?anoaiey yaeaiee aeeaaaoe/aneie iao?iiaoee – oae, anee o aieueiuo n aeeaaaoe/aneie iao?iiaoeae II noaaeee ioia/aeinue caiaaeeaiea aaiiciiai iooiea, o aieueiuo n aeeaaaoe/aneie iao?iiaoeae III noaaeee auyaeyeenue oaea yaeaiey aaiiciiai noaca. Cieaeaiea aaiiciiai iooiea ii ioiioaieth e a?oa?eaeueiiio i?eoieo, caeaeaoaeuenoaoao i ianinoiyoaeueiinoe i?eiinyueo e auiinyueo a?oa?eie a eeoai/eao ii/ae, eioi?ia eiaao ianoi oaea ia aeieeeie/aneii yoaia ?acaeoey aeeaaaoe/aneie iao?iiaoee. Auyaeaiiua ia?ooaiey oeeueo?aoeeiiii-yene?aoi?iie ooieoeee ii/ae, ii/a/iiai e?iaioiea ?acaeaathony ia ?aiieo noaaeeyo aeeaaaoe/aneie iao?iiaoee aua aei iiyaeaiey iee?iaeueaoieio?ee. I?iaaaeaii eco/aiea ooieoeeiiaeueiuo iieacaoaeae ii/ae ia oiia iacia/aiey i?aia?aoa - eiaeaeoi?a aiaeioaiceii?aa?auathuaai oa?iaioa – eaioii?eea. Iaia?oaeaii, /oi iaeiie?aoiia iacia/aiea eaioii?eea i?eaiaeeo e nieaeaieth aacaeueiiai o?iaiy ieiooiiai iauaia eeoai/eiaie oeeueo?aoeee oieueei o aieueiuo n enoiaeiie aeia?oeeueo?aoeeae n aeeaaaoe/aneie iao?iiaoeae II noaaeee, e iiauoatho oia?aiii iiauoaiiue ieiooiue iauai eeoai/eiaie oeeueo?aoeee o aieueiuo n aeeaaaoe/aneie iao?iiaoeae III noaaeee. Onoaiiaeaii, /oi eciaiaiey ia?aiao?ia ii/a/iie aaiiaeeiaieee a ioaao ia aaaaeaiea eaioii?eea caaenyo io noaaeee aeeaaaoe/aneie iao?iiaoee e iiaoo io?aaeaoue ?aaeoeaiinoue aeiia?oey?iie aaiiaeeiaieee. Ia oiia iaaeeeaiaioiciie i?iau n ianoa?ieaeiui i?ioeaiainiaeeoaeueiui i?aia?aoii – eiaeiiaoaoeeiii, eco/ai oa?aeoa? eciaiaiee ia?oeeaeueiuo ooieoeee e aaiiaeeiaie/aneeo iieacaoaeae ii/ae ia ?aiieo noaaeeyo ?acaeoey aeeaaaoe/aneie iao?iiaoee o aieueiuo n I oeiii naoa?iiai aeeaaaoa. Iieacaii, /oi aeey aieueoeinoaa aieueiuo naoa?iui aeeaaaoii I oeia n yaeaieyie iao?iiaoee oa?aeoa?iui yaeyaony eca?auaiea aaeaeaaoiie ?aaeoeee ia aaaaeaiea i?aia?aoa eiaeaeoi?a neioaca i?inoaaeaiaeeiia - eiaeiiaoaoeeia, i?iyaeythuaany a aeaeueiaeoai ia?anoaiee nei?inoe eeoai/eiaie oeeueo?aoeee, i?e/ai yoe naeaeae ?acaeaathony ia ?aiieo noaaeeyo aeeaaaoe/aneie iao?iiaoee. ?aciiiai?aaeaiiua ?aaeoeee ia aaaaeaiea eiaeiiaoaoeeia, eioi?ua i?iyaeythony o aieueoeinoaa aieueiuo n ?aiieie noaaeeyie aeeaaaoe/aneie iao?iiaoee iiauoaieai ieiooiiai iauaia eeoai/eiaie oeeueo?aoeee, o ae?oaeo – nieaeaieai aeaiiiai iieacaoaey, iicaieytho auyaeoue eiaeeaeaeoaeueiua ?aaeoeee aieueiuo ia i?aia?ao e ?aeiiaiaeiaaoue eiaeiiaoaoeei aeey ea/aiey noaeeeie/aneeo noaaeee aeeaaaoe/aneie iao?iiaoee. Ioa?aeoa?eciaaii ninoiyiea aoii?aeueiiai eiioieoaoa, auyaeaiu iniaaiiinoe i?iaeoeoeee eiioiiaeiaoeeiia ?acee/iuo eeannia, aioeoae e aacaeueiie iaia?aia eeoai/eia ii/ae o aieueiuo n ?acee/iuie, a oii /enea aeieeeie/aneeie, noaaeeyie aeeaaaoe/aneie iao?iiaoee. Enneaaeiaaiey iieacaee, /oi /enei aieueiuo n iieiaeeoaeueiie ?aaeoeeae ia iaee/ea aooiaioeoae e aacaeueiie iaia?aia eeoai/eia ii/ae ?anoao ii ia?a oneeaiey au?aaeaiiinoe eeeie/aneeo i?iyaeaiee aeeaaaoe/aneie iao?iiaoee. I?e yoii aieueoay /anoue iaoeeaioia n iieiaeeoaeueiie ?aaeoeeae ia aioeoaea eiaao III-IV noaaeeth ?acaeoey aeeaaaoe/aneie iao?iiaoee. I?e aiaeeca eciaiaiee eiioeaio?aoeee eiioiiaeiaoeeiia a nuai?ioea e?iae iaoeeaioia, n ?aciie noaiaiueth aeeaaaoe/aneie iao?iiaoee auynieeinue, /oi o?iaaiue Ig G iaeneiaeai i?e ia/aeueiuo noaaeeyo einoeeicaaeneiiai naoa?iiai aeeaaaoa (aac auyaeaiiie AeI), caoai iinoaiaiii nieaeaaony, a o?iaaiue Ig I eiaao oaiaeaioeeth e iiauoaieth, aeinoeaathuoth noaoenoe/aneie cia/eiinoe o aieueiuo n au?aaeaiiie iao?iiaoeae. Onoaiiaeaii, /oi o iaoeeaioia n auyaeaiiuie aioeoaeaie e aacaeueiie iaia?aia ii/ae iiauoaiu iieacaoaee niioiioaiey eiioeaio?aoeee eiioiiaeiaoeeiia eeannia IgG/IgD e IgM/IgD, e nieaeaiu iieacaoaee niioiioaiey eiioeaio?aoeee eiioiiaeiaoeeiia IgA/IgG e IgA/IgM. I?iaaaeaiiia eco/aiea oa?aeoa?a eciaiaiee o?iaiy oee?eoee?othueo eiioiiaeiaoeeiia e i?iaeoeoeee aooiaioeoae e aacaeueiie iaia?aia eeoai/eia ii/ee o aieueiuo einoeeicaaeneiui naoa?iui aeeaaaoii n ?aciuie noaaeeyie aeeaaaoe/aneie iao?iiaoee, naeaeaoaeuenoaoao ia o/anoee aooieiioiiuo iaoaieciia a ?acaeoee e i?ia?anne?iaaiee aeaiiiai ineiaeiaiey. A ?acoeueoaoa i?iaaaeaiiuo enneaaeiaaiee, oaeoaeaiu i?aaenoaaeaiey i iaoioeceieiae/aneeo iaoaieciao oi?ie?iaaiey ?aiieo noaaeee ii?aaeaiey ii/ae o aieueiuo n einoeeicaaeneiui naoa?iui aeeaaaoii. ?ac?aaioaiu iiaeoiaeu e aeeaaiinoeea ?aiieo noaaeee aeeaaaoe/aneie iao?iiaoee. Eeth/aaua neiaa: aeeaaaoe/aneay iao?iiaoey, nei?inoue eeoai/eiaie oeeueo?aoeee, iee?iaeueaoieio?ey, aioeoaea e aacaeueiui iaia?aiai eeoai/eia ii/ae, eiioiiaeiaoeeiu. ANNOTATION Tadjieva I. Ch. "Early diagnosis of diabetic nephropathy in patients with insulin dependent diabetes mellitus". - Manuscript. Dissertation for the competition of candidate’s degree of medical sciences specializing in endocrinology 14. 01. 14. – Endocrinology. V.P.Komisarenko Institute of Endocrinology and Metabolism of AMS, Kyiv, 1999. The changes in the filtration-excretion renal function, renal hemodynamics that are manifested as the differently directed changes in the minute volume of glomerular filtration, in the time of maximum accumulation, in the time of semi-excretion radiopharmpreparation, in a decrease of the renal circulatory rate and relative venous renal capacity in the patients with preclinical stages of diabetic nephropathy were studied. The character of changes in the partial functions and hemodynamical renal indices at early stages of diabetic nephropathy in the patients with type I diabetes mellitus were studied against the background of medicamentous tests with the angiotensin-converting enzyme inhibitor – captopril, nonsteroid antiinflammatory preparation – indometacin. It was demonstrated that the perversion of adequate reaction to indometacin, manifesting in the subsequent increase in the glomerular filtration velocity, these changes are developed at the early stages of nephropathy is typical for the patients with type I diabetes mellitus and features of nephropathy. It was determined that the changes in parameters of renal hemodynamics in response to captopril administration are dependent on the stage of diabetic nephropathy and can reflect the reactivity of glomerular hemodynamics. The state of humoral immunity was characterized, the peculiarities of production of different class immunoglobulins, antibodies against basal membranes of renal glomerulus in patients with different stages of diabetic nephropathies including preclinical stages were revealed. As a result of investigations undertaken, the ideas about pathophysiological mechanisms forming early stages of renal affection in patients with IDDM became deeper. The approaches to diagnosis fore early stages of diabetic nephropathe were developed. Key words: diabetic nephropathy, velocity of glomerular filtration, microalbuminuria, antibodies to basal membranes of renal glomerulus, immunoglobulins.

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