Прогнозування та профілактика залізодефіцитної анемії у вагітних, що проживають в екологічно несприятливих умовах: Автореф. дис… канд. мед. наук / О

I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

A?IIEOeUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO ?i. I.?. IE?IAIAA

I?IOeAIEI IEAENAIAe? IEAEN?EIAE*

OAeE 618.3:616.155.194-084-037:541.12.038

I?IAIICOAAIIss OA I?IO?EAEOEEA CAE?CIAeAO?OeEOII? AIAI?? O AAA?OIEO, UI
I?IAEEAATHOUe A AEIEIA?*II IANI?EssOEEAEO OIIAAO

14.01.01 — aeooa?noai oa a?iaeieia?y

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

A?IIEOess — 1999

Aeena?oaoe?y ? ?oeiiecii

?iaioa aeeiiaia ia eaoaae?? aeooa?noaa oa a?iaeieia?? ? 1 A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?.Ie?iaiaa IIC Oe?a?ie.

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? Iaci?/oe Ai?en Oaaei?iae/,
caa?aeoaa/ eaoaae?e aeooa?noaa oa a?iaei- ia?? ?1
A?iieoeueeiai aea?aeaaiiai iaaee/- iai oi?aa?neoaoo ?i.
I.?.Ie?iaiaa

IIC Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani?

O?ai/oe Aiaoie?e THoeiiae/,

i?ioani? eaoaae?e aeooa?noaa oa

a?iaeieia?? iaaee/iiai oaeoeueoaoo

Oa?iii?euenueei? aea?aeaaii? iaaee/ii?

aeaaeai?? ?i. ?.ss.Ai?aa/aanueeiai

IIC Oe?a?ie;

aeieoi? iaaee/ieo iaoe, i?ioani?

Iena??aa Na?oeaia Iao??aia,

caa?aeoth/a a?aeae?eaiiyi iaoeiaeo i?iaeai aaeiiooaaiiy
aaa?oiino? ?inoeoooo

iaae?ao??? aeooa?noaa oa a?iaeieia??

AII Oe?a?ie

I?ia?aeia onoaiiaa: Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe
?i. I.E.Ooieea IIC Oe?a?ie, eaoaae?a aeooa?noaa oa a?iaeieia?? ?1

Caoeno a?aeaoaeaoueny “26” aeiaoiy 1999 ?. i 1200 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee E 05. 600. 01 i?e A?iieoeueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i. I.?. Ie?iaiaa IIC Oe?a?ie
(286018, i. A?iieoey, aoe. Ie?iaiaa, 56).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? A?iieoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.?. Ie?iaiaa IIC Oe?a?ie
(286018, i.A?iieoey, aoe. Ie?iaiaa, 56).

Aaoi?aoa?ao ?ic?neaii “ _26_”_aeiaoiy 1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

eaiaeeaeao iaaee/ieo iaoe, aeioeaio I.?.Iieeaeueei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie

A no/aniiio aeooa?noa? i?iaeaia cae?ciaeao?oeeoii? aiai?? (CAeA), yea
aeieea? o ae?oa?e iieiaei? aaa?oiino?, iaaoea iniaeeaiai cia/aiiy. Ca
aeaieie a?o/eciyieo aaoi??a CAeA aaa?oieo iinooiiai caeiyea i?ia?aeia
i?noea na?aae an?o oneeaaeiaiue aaa?oiino? (Noaiaieianeay A.E. e ae?.,
1992; Nai/oe A.ss. e ae?.,1993;Oeiioaiei E.A.,1993). Ca inoaii? ?iee
niinoa??aa?oueny iinooiiaa c?inoaiiy /anoioe aeieeiaiiy
cae?ciaeao?oeeoii? aiai?? na?aae aaa?oieo ??cieo ?aa?ii?a Oe?a?ie (Ia/a?
O.O., 1991; Nai/oe A.ss., 1995; Ia?aieiaa ?.I., 1998; Oooi?iee N.I.,
1999).

Ca ??cieie aeaieie ca inoaii? 10 ?ie?a e?euee?noue aiai?e na?aae
aaa?oieo ca?eueoeeanue iaeaea o 8-15 ?ac?a (Cii?ie A.A. oa ?i.,1992 ;
Oeiioaiei E.A., e ae?. 1992). O anueiio na?o? ?iciianthaeaeaiiy aiai??
na?aae aaa?oieo nueiaiaei? ioe?ith?oueny o 50-51% (Roodenburg F., 1995),
aea o ?icaeiooeo e?a?iao oe? aeai? ia ia?aaeuothoue 14-30% (CDC, 1989;
Cook J.D., et al. 1992; Milman N., 1996).

O a?o/eciyi?e e?oa?aoo?? ?ice?eooth i?e/ei ?inoo /enea aaa?oieo, oai?eo
ia CAeA, i?enay/aii iaaaaaoi ?ia?o. I?ney aaa??? ia *AAN c’yaeeenue
niinoa?aaeaiiy ?inoo aeayeeo aeae?a aeooa?nueei? iaoieia??, cie?aia
aiai?? aaa?oieo (Noaiaieianeay A.E., e ae?. 1992; Oeiioaiei E.A. e ae?.,
1992).

??ci? aaoi?e ioe?iththoue aieea iaeeo aeic ?ii?coth/iai aei?ii?ithaaiiy
ia ?ai?iaeoeoeaio ooieoe?th iaiaeiicia/ii (?oaeiaa I.E. e ae?., 1994;
Ethaa?aoe O.O., 1995; Iacaiaea I.I. oa ni?aaao. 1996; Aeiaeeia E.A.,
1998). ?iaioe inoaiiueiai aeanyoe??//y a?o/eciyieo ? ca?oa?aeieo aaoi??a
caa?oathoue iniaeeao oaaao ia c?inoaiiy ia o?eueee aeieia?/ieo,
iaaeeei-a?ieia?/ieo, aea e nioe?aeueii-aeiiii?/ieo /eiiee?a a ?icaeoeo
aeooa?nueei? iaoieia??, a oiio /ene? ? aiai?? aaa?oieo (?icuaaa Y.,
1991; Aiaaeaoeei I.A. e ae?., 1992; Ia/a? O.O., 1992; Aai?iaa E.I.,
1996).

Oaeei /eiii, a?aoiaoth/e no/ani? caaaeaiiy c anoaiiaeaiiy
?iciianthaeaeaiiy caoai?thaaiue, aeineoue aeooaeueiei ? aea/aiiy
ai?aeai?ieia?? cae?ciaeao?oeeoii? aiai?? na?aae aaa?oieo ??cieo iaeanoae
(CDC, 1989; Hallberg L., 1992).

Ia nueiaiaei?oi?e aeaiue aeinoaoiuei ?ic?iaeaia noaia oa?ai?? CAeA c
o?aooaaiiyi ao?ieia?/ieo ? iaoiaaiaoe/ieo /eiiee?a ?icaeoeo oe???
iaoieia?? o aaa?oieo (Aciaaoeiaa Ae.A. e ae?., 1989; Breymann C. et al.,
1995; Herrmann R.P., 1994; Lops V.R., 1995).

I?ioa ieoaiiy i?io?eaeoeee CAeA aaa?oieo o a?o/eciyi?e iaoeia?e
e?oa?aoo?? ina?oeai? iaaeinoaoiuei. I??e i?io?eaeoeee CAeA noinothoueny,
a iniiaiiio, aeyaeaiiy a aiaoeaoi?ieo oiiaao ? a oiiaao aeaiiiai
noaoe?iia?o aaa?oieo c aenieei nooiaiai ?eceeo ?icaeoeo aiai??,
i?ecia/aiiy a?oai?i?a, cie?aia anei?a?iiai? eeneioe, oa, a?aoiaoth/e, ui
iniiaiee oeyo iaaeoiaeaeaiiy cae?ca a i?aai?ci — ae?iaioa?iee,
?ic?iaeai? ?aeiiaiaeaoe?? ii oa?/oaaiith aaa?oieo ? ai?iaaaeaeai?
niaoe?aeuei? ae??oe/i? i?iaeoeoe (Noa?inoeia O.A. e ae?., 1990;
Noaiaie?anueea A.E., 1992; Beard J.L., 1994; Donovan U.M., 1995).

Aea caeeoa?oueny aeeneon?eiei ieoaiiy — /e caaeiaieueiyoue ia?ae?/ai?
i??e c?inoath/o ii i??? i?ia?anoaaiiy aaa?oiino? iio?aao i?aai?cio
iaoa?? ? ieiaea a cae?c? (Aa?aneiaiei A.A., 1989; Oaaeaaa C.O., 1989;
Aieiaei A.A., 1992; Nai/oe A.ss., 1995; Eskeland B. et al., 1993).

I?iaeaia i?io?eaeoeee aiai?? ia? aeaa aniaeoe — ia?aeiiee ??aaiue
caian?a cae?ca a i?aai?ci? ? aaeaeaaoi?noue ianya?a iaaeoiaeaeaiiy
cae?ca c ?aeath (Neiae?oeaaa A.Ae., 1998; Edwards C.Q., et al. 1991;
Simons W.K., 1994). O no/ani?e e?oa?aoo?? oe? ieoaiiy aena?oeai?
iaaeinoaoiuei. Oe?iea ?iciianthaeaeaiiy CAeA na?aae aaa?oieo, ui
niinoa??aa?oueny a inoaii? ?iee, aeiaiaeeoue iaaoaeoeai?noue ei?aeoe??
oa?/oaaiiy ye i?io?eaeoe/ii? i??e uiaei CAeA a oiiaao ae?? iani?eyoeeaeo
aeieia?/ieo /eiiee?a, caeeoathoueny iaaeinoaoiuei aoaeoeaieie ? iaoiaee
e?eoaaiiy CAeA.

Icia/ai? ianoaaeie aeeeoothoue iaiao?aei?noue aea/aiiy iaoiaaiaco CAeA ?
i?aeai?o iaea?eueo aoaeoeaieo i?aia?ao?a, ui aieeaathoue ia o?eueee ia
iieacieee /a?aiii? e?ia?, aea e ia ??aaiue caian?a cae?ca a i?aai?ci?, ?
aeicaieyoue ei?eaoaaoe aeiee?i?/i?, eaoaioi? ci?ie iai?io cae?ca a
i?aai?ci? aaa?oii? ae?iee.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa aeeiiaia a ?aieao iaoeiai? oaiaoeee eaoaae?e aeooa?noaa ?
a?iaeieia?? ?1 A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.
I.?.Ie?iaiaa “Ee?i?ei-iaoaiaoe/i? iaoiaee i?iaiicoaaiiy, i?io?eaeoeee,
e?eoaaiiy aeayeeo aeae?a aeooa?nueei? ? a?iaeieia?/ii? iaoieia??
aiane?aeie ae?? oaeoi??a ciai?oiueiai na?aaeiaeua ? ae?iaieoeoaa”
(1996-2000). Oeo? oaie: 616-099:616,621-08:547.23 ? aea?ae?a?no?aoe??
0196U004907.

Iaoith aeaii? ?iaioe ? oaeineiiaeaiiy oa?ai?? cae?ciaeao?oeeoii? aiai??
aaa?oieo aeey cieaeaiiy e?eueeino? oneeaaeiaiue i?ae /an aaa?oiino?,
iieia?a, i?neyiieiaiaiai ia??iaeo o iaoa??, ieiaea oa iiaiia?iaeaeaiiai
a no/anieo oiiaao.

Aeey ?aae?caoe?? iinoaaeaii? iaoe ae??ooaaee ianooii? caaaeaiiy:

1. Aea/aii ai?aeai?ieia?th ?iciianthaeaeaiiy aiai?? na?aae aaa?oieo a
o?ueio iaeanoyo (??aiainuee?e, A?iieoeuee?e, Euea?anuee?e) ? aieea ?? ia
ia?aa?a aaa?oiino?, iieia?a, noai ieiaea ? iiaiia?iaeaeaiiai a oiiaao
ae?? iani?eyoeeaeo aeieia?/ieo /eiiee?a.

2. Aeae?eaii oaeoi?e ?eceeo ? aecia/aii iiaeeea? i?e/eie c?inoaiiy
/anoioe cae?ciaeao?oeeoii? aiai?? na?aae aaa?oieo cacia/aiiai ?aa?iio ca
inoaii? ?iee.

3. Aeine?aeaeaii oa?aeoa? ci?i iai?io cae?ca a i?aai?ci? ae?iee i?e
i?ia?anoaaii? aaa?oiino? ? aecia/aii iaoiaaiaoe/ia cia/aiiy oeeo ci?i o
?icaeoeo CAeA aaa?oieo.

4. ?ic?iaeaii ? ai?iaaaeaeaii a ee?i?/io i?aeoeeo i?iaiinoe/i? e?eoa???
?icaeoeo CAeA ? aecia/aii iieacaiiy aeey i?ecia/aiiy i?aia?ao?a cae?ca.

5. I?iaaaeaii ii??aiyeueiee aiae?c aoaeoeaiino? canoinoaaiiy i?aai?/ieo
? iai?aai?/ieo nieae cae?ca aeey iiiiaiaiiy eiai aeaii, ia i?aenoaa?
/iai ?ic?iaeaii ? ai?iaaaeaeaii a i?aeoeeo eiiieaen caoiae?a aeey
aaa?oieo a?oie ?eceeo ?icaeoeo CAeA, ui i?ecia/a?oueny a ?aii? oa?i?ie
aaa?oiino?.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aeine?aeaeaii
ai?aeai?ieia?th ?iciianthaeaeaiiy CAeA na?aae aaa?oieo a o?ueio iaeanoyo
Oe?a?ie ca inoaii? 11 ?ie?a ? aea/aii /anoioo cae?ciaeao?oeeoiiai noaio
na?aae iaaaa?oieo ae?iie ?ai?iaeoeoeaiiai a?eo ?aa?iio, ui
aeine?aeaeoaaany. ?ic?iaeaii iaoaiaoe/io iiaeaeue i?iaiico ?inoo /anoioe
CAeA na?aae aaa?oieo ? aecia/aii i?iaiic na?aae aaa?oieo A?iieoeueei?
iaeano? ia iaeaeeae/? /ioe?e ?iee. Aeyaeaii oaeoi?e ?eceeo, oa i?e/eie
?inoo CAeA aaa?oieo o cacia/aieo ?aa?iiao ca inoaii? ?iee.

Anoaiiaeaii ci?ie iai?io cae?ca i?e i?ia?anoaaii? aaa?oiino?. Aecia/aii,
ui CAeA — inoaiiy noaae?y aeeiai?/ieo ci?i iai?io cae?ca. Cai?iiiiiaaii
iiiyooy “i?aaiai?y” (cae?ciaeao?oeeoiee noai) — eaoaioi? ci?ie iai?io
cae?ca, ui ia?aaeothoue ci?iai iieaciee?a /a?aiii? e?ia? aaa?oieo.

Aecia/aii, ui aeey ?icaeoeo aiai?? ia? cia/aiiy ii/aoeiaa aaeaeaaoi?noue
aeaii cae?ca a i?aai?ci? ae?iee. Aacoth/enue ia oeueiio, ?ic?iaeaii
e?eoa??? ioe?iee aaeaeaaoiino? aeaii cae?ca i?ae /an aaa?oiino? oa
iieacaiiy aeey i?ecia/aiiy i?aia?ao?a cae?ca o ?aii? oa?i?ie aaa?oiino?.

I?iaaaeaii ii??aiyeueio ioe?ieo aoaeoeaiino? canoinoaaiiy i?aai?/ii? oa
iai?aai?/ii? nieae cae?ca.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?acoeueoaoe eiiieaeniiai
ee?i?ei-eaai?aoi?iiai aeine?aeaeaiiy aeathoue iiaeeea?noue aecia/aoe
aaa?oieo c aenieei nooiaiai ?eceeo aeieeiaiiy CAeA a ?aii? oa?i?ie
aaa?oiino?.

Iaea?aeai? ?acoeueoaoe ci?i iai?io cae?ca ? ciaeaeai? ii?iaia? cia/aiiy
??aiy ne?iaaoeiaiai oa?eoeio (NO) aeicaieythoue a ?aii? oa?i?ie
aaa?oiino? i?iaiicoaaoe ?icaeoie CAeA ? aecia/aoe iaiao?aei?noue
i?ecia/aiiy i?aia?ao?a cae?ca aeey i?io?eaeoeee CAeA oeyoii e?eoaaiiy
cae?ciaeao?oeeoiiai noaio, a oaeiae ioe?ithaaoe aaeaeaaoi?noue
canoiniaaii? oa?ai??.

Iieacaii, ui canoinoaaiiy i?aai?/ii? nie? cae?ca — aetheiiaoo (a neeaae?
i?aia?aoo “Oioaia”) aeey e?eoaaiiy i?aaiai?? (cae?ciaeao?oeeoiiai noaio)
? i?io?eaeoeee aeieeiaiiy CAeA ii i??? i?ia?anoaaiiy aaa?oiino?
aeicaiey? aeinyaoe a?eueo ae?aaeaieo iiceoeaieo ?acoeueoao?a nei??oa,
i?ae canoinoaaiiy iai?aai?/ii? nie? — noeueoaoo cae?ca (a neeaae?
i?aia?aoo “Aeoeoa?ei”).

Ia oe? i?iaaaeaieo aeine?aeaeaiue aeey aeooa?nueei? i?aeoeee ?ic?iaeaii
? ai?iaaaeaeaii eiiieaen caoiae?a c i?io?eaeoeee CAeA o aaa?oieo c
?aii?o oa?i?i?a aaa?oiino?.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii naiino?eii i?iaiae?ciaaii
iaoeiao e?oa?aoo?o oa iaoaioio ?ioi?iaoe?th c i?iaeaie aiai?? aaa?oieo,
aecia/aii iaoo oa caaaeaiiy aeine?aeaeaiiy. ?ic?iaeaii aieaoe oa
i?iaaaeaii aieaooaaiiy aaa?oieo oa iaaaa?oieo ae?iie aeey aecia/aiiy
oaeoi??a ?eceeo ?icaeoeo CAeA i?ae /an aaa?oiino?. Aaoi? naiino?eii
i?ia?a ia?iaeo noaoenoe/ieo iaoa??ae?a o ?aa?iiao, oi?ioaaiiy a?oi
oai?eo, ?ino?oiaioaeuei? oa eaai?aoi?i? aeine?aeaeaiiy, ia?aeiio ia?iaeo
?acoeueoao?a ianoaaeaiue.

Iniaenoi aeena?oaioii i?iaaaeaii noaoenoe/iee aiae?c ?acoeueoao?a
aeine?aeaeaiiy, iaienaii an? ?icae?ee aeena?oaoe??, noi?ioeueiaaii
aeniiaee oa cai?iiiiiaaii i?aeoe/i? ?aeiiaiaeaoe??, caaacia/aii ?o
ai?iaaaeaeaiiy a iaaee/io i?aeoeeo oa a?aeia?aaeaiiy a iioae?eiaaieo
i?aoeyo.

Ai?iaaoe?y ?acoeueoao?a aeine?aeaeaiiy. Iniiai? iieiaeaiiy ?iaioe
aeiiia?aeaeeny ia iaoeia?e eiioa?aioe?? iieiaeeo a/aieo “Aeooaeuei?
ieoaiiy aeooa?noaa ? a?iaeieia??” (A?iieoey, 1995); iaoeiai-i?aeoe/i?e
eiioa?aioe?? “Ia?niaeoeau nie?oeeiu a aeioaoiieiaeyo ieoaiey e
oa?iaeieiaee” (A?iieoey, 1997); I?aeia?iaei?e eiioa?aioe??, i?enay/ai?e
25-??//th ee?i?/ii? oa?iaeieia?? (Iineaa, 1997); eiioa?aioe?? iieiaeeo
a/aieo — naeoe?y “Aeooaeuei? i?iaeaie ioi?iie iaoa?einoaa oa
aeeoeinoaa” (A?iieoey, 1998); Ae?oaiio i?aeia?iaeiiio eiia?an? c
?ioaa?aoeaii? aio?iiieia?? (A?iieoey, 1998); Ae?oaiio i?aeia?iaeiiio
iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1998);
I?aeia?iaeiiio neiiic?oi? “Aeooaeuei? i?iaeaie a?io?ce/ii? iaaeeoeeie”
(Ee?a, 1998).

Ai?iaaoe?th aeena?oaoe?eii? ?iaioe i?iaaaeaii ia ni?eueiiio can?aeaii?
eaoaae? aeooa?noaa oa a?iaeieia?? ?1 ? ?2, caaaeueii? o??o?a??,
a?io?i??, iaoieia?/ii? aiaoii??, nioe?aeueii? a?a??ie ? i?aai?caoe??
ioi?iie caei?ia’y A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.
I.?.Ie?iaiaa.

Iniiai? ?acoeueoaoe aeine?aeaeaiiy aeei?enoiaothoueny a i?aeoeoe? ?iaioe
iieiaiaeo aoaeeie?a i. A?iieoe? oa a iaa/aeueiiio i?ioean? ia eaoaae?ao
aeooa?noaa oa a?iaeieia?? ?1 ? ?2, eo?nao aaiaoieia?? ? ee?i?/ii?
oa?iaeieia?? A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i.
I.?.Ie?iaiaa.

Ioae?eaoe??. Ii oai? aeena?oaoe?? iioae?eiaaii 10 ?ia?o: 7 noaoae o
i?ia?aeieo iaoeiaeo aeo?iaeao, 3 — a iaoa??aeao eiioa?aioe?e oa oacao
aeiiia?aeae.

No?oeoo?a ? ianya aeena?oaoe??. Aeena?oaoe?eia ?iaioa aeeeaaeaia ia 147
ae?oeiaaieo noi??ieao ? neeaaea?oueny c? anooio, iaeyaeo e?oa?aoo?e,
naie ?icae?e?a aeanieo aeine?aeaeaiue, iaaiai?aiiy io?eiaieo
?acoeueoao?a, aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e ? nieneo aeei?enoaieo
aeaea?ae, yeee ia?aoiao? 144 oe?a?inueei- oa ?in?enueeiiiaieo ? 64
?iicaiieo aeaea?ae. ?iaioa ?ethno?iaaia 30 oaaeeoeyie ? 5 ?enoieaie.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy Aeey aiae?co ?iciianthaeaeaiiy CAeA
na?aae aaa?oieo iaie aoee a?ae?a?ai? Euea?anueea, ??aiainueea ?
A?iieoeueea iaeano?, ui iathoue ??cio aeieia?/io oa?aeoa?enoeeo ca
??aiai ?aae?iioee?aeieo aieea?a. Aeey oa?aeoa?enoeee o?i?/ieo ?
?aae?aoe?eieo oaeoi??a ioi/oth/iai na?aaeiaeua cacia/aieo iaeanoae
aeei?enoaee aeai? nai?oa?ii-ai?aeai?/ii? oa a?ae?iiaoaineoaeae, aeaeai?
o ui??/ieo ca??ieeao I?i. Aeiaaciaee c 1992 ii 1996 ?iee ? I?i.
*i?iiaeey Oe?a?ie c 1989 aei 1996 ?ieo.

Ai?aeai?ieia?th CAeA aaa?oieo aea/aee ca aeaieie ui??/ieo “Ca?o?a i?i
iaaee/io aeiiiiiao aaa?oiei, ?iae?eeyi ? ii?iae?eeyi” (oi?ia ?21,
caoaa?aeaeaia iaeacii I?i?noa?noaa noaoenoeee Oe?a?ie a?ae 20.05.1994?.,
ca?o ?3) 67 ?aeiiieo iaaee/ieo onoaiia cacia/aieo iaeanoae c 1985 aei
1996 ?ieo.

I?iaiicoaaiiy ?inoo aiai?? na?aae aaa?oieo ia ianooii? /ioe?e ?iee
i?iaaaeaii ca aeaieie A?iieoeueei? iaeano? iaoiaeii aiae?co /aniaeo
?yae?a (iiaeaethaaiiy ca Aienii-Aeaeaie?inii).

Iniaeeaino? ia?aa?ao aaa?oiino? oa iieia?a o ae?iie ?c CAeA aaa?oieo,
eio?? iaoeathoue a aeieia?/ii iani?eyoeeaeo oiiaao, aea/aee oeyoii
ii??aiyeueiiai aiae?co ?noi??e iieia?a 163 aaa?oieo c CAeA (? — iniiaia
a?oia), eio?? iaoeathoue o i?no? c ??aiai o?i?/iiai oa ?aae?aoe?eiiai
caa?oaeiaiiy, ui ia?aaeuo? ii?iaeuei? cia/aiiy, c aeaieie i?i 102
aaa?oieo c CAeA (?? a?oia — ii??aiyiiy) aeieia?/ii /enoiai ?aeiio
A?iieoeueei? iaeano?.

Aeey aecia/aiiy oaeoi??a ?eceeo oa /eiiee?a c?inoaiiy CAeA aaa?oieo ca
aeiiiiiaith niaoe?aeueii ?ic?iaeaii? aieaoe iaie i?iaaaeaii iieooaaiiy
128 ae?iie o oa?i?i? 37-40 oeaei?a aaa?oiino?. Ca ??aiai aaiiaeia?io
e?ia? aaa?oi? ?iciiae?eai? ia aea? a?oie. Iniiaio, I-o a?oio (49 in?a) —
neeaee ae?iee c cae?ciaeao?oeeoiith aiai??th, a yeeo ia i?ioyc? anueiai
aanoaoe?eiiai ia??iaeo na?aaei?e ??aaiue aaiiaeia?io aoa iaioa 100 a/e
(94,8±0,66 a/e). Aei eiio?ieueii?, ??-? a?oie a?aeianai? 79 ae?iie c
na?aaei?i ??aiai aaiiaeia?io i?ioyaii aaa?oiino? a?eueoa 110a/e
(116,96±0,86 a/e). Ia i?aenoaa? a?aeiia?aeae ae?iie i?iaaaeaii
ii??aiyeueiee aiae?c iaio a?oi. Oaeoe/ia oa?/oaaiiy ioe?ithaaee ca
aeiiiiiaith ?ic?iaeaii? iaie aaeueii? iaoiaeeee.

Ca iaoiaeeeith aeiaaeeiai? aea??ee a?ae?a?aii ? ianoaaeaii iai?i cae?ca
o 64 i?aeoe/ii caei?iaeo iaaaa?oieo ae?iie a?ae 17 aei 35 ?ie?a. 85% c
ieo ieaiothoue noaoe iaoa?yie oi?iaeiaae ianooiieo 2-4 ?ie?a.

Aeey aecia/aiiy iieaciee?a iai?io cae?ca o aaa?oieo a ??ci? oa?i?ie
ianoaaeaii 111 ae?iie. A 1 o?eiano?? (na?aaei?e oa?i?i aaa?oiino? neeaa
11,2±0,08 oeae.) ianoaaeai? 42 ae?iee, a ae?oaiio o?eiano?? (23,3±0,11
oeae.) — 36 ? a o?aoueiio (37,2±0,08 oeae.) — 33 ae?iee.

Aeey ?ic?iaee ? ioe?iee aoaeoeaiino? cai?iiiiiaaieo
e?eoaaeueii-i?io?-eaeoe/ieo caoiae?a o aaa?oieo, ye? iaoeathoue a
aeieia?/ii iani?eyoeeaeo oiiaao, iaie aoei aeiaeaoeiai ianoaaeaii 77
aaa?oieo ae?iie. Ia?oo a?oio neeaee 19 ae?iie, eio?? i?eeiaee i?aia?ao
“Oioaia”, ui i?noeoue i?aai?/io n?eue — aetheiiao cae?ca; ae?oao — 22
ae?iee, ye? aeei?enoiaoaaee aaceniee i?aia?ao “Aeoeoa?ei” c
iai?aai?/iith n?eeth – noeueoaoii cae?ca. Eiio?ieueio a?oio (36 in?a)
neeaee ae?iee, ye? ia io?eioaaee cae?cioa?ai??. Aaa?oi? ianoaaeai? aei
i?ecia/aiiy i?aia?ao?a (na?aaei?e oa?i?i — 13,3±0,09 oeae.) oa /a?ac
i?aoi?a i?nyoe? i?ney i?ecia/aiiy.

O an?o ianoaaeaieo ae?iie aecia/aee eiioeaio?aoe?th caaaeueiiai
aaiiaeia?io niaeo?ioioiiao?e/iei iaoiaeii, ne?iaaoeiaiai cae?ca (aeae?
NC), cae?ai?noue ne?iaaoee ca’ycoaaoe cae?ci (CNCC), ??aaiue iane/aiiy
o?ainoa?eio cae?cii (IO) — aaoioaiaio?ie?iiaei i?e?iiaoiaeii,
e?euee?noue a?eo?ioeeo?a ? ?io? iieacieee caaaeueiiai aiae?co e?ia?,
a?eo?ioeeoa?i? ?iaeaene aecia/aee ia aaiiaiae?caoi?? HC 5710 o??ie
“Danam”. Eiioeaio?aoe?th ne?iaaoeiaiai oa?eoeio (NO) aecia/aee
?aae?i?ioiiei iaoiaeii c aeei?enoaiiyi iaai??a K?T “??iioa?eoei”,.

An? io?eiai? aeai? ia?iaeai? iaoiaeaie aeane?eioeaii? noaoenoeee.

Iniiai? ?acoeueoaoe aeine?aeaeaiiy

Ii??aithth/e aeieia?/iee noai o o?ueio iaeanoyo ca 1985-1996 ?iee,
anoaiiaeaii, ui ia oa?eoi??? niinoa?aaeaieo iaeanoae aeieia?/i? oiiae
iani?eyoeea? aeey i?aai?cio aaa?oii? ae?iee. Ca ??aiai o?i?/iiai
caa?oaeiaiiy o?e iaeano? iiaeia aaaaeaoe iiae?aieie. C 1986 ?ieo ??aaiue
?aae?aoe?eiiai caa?oaeiaiiy iaea?eueoee o ??aiainuee?e iaeano?
(1,77±0,32 iCa.??e-1), i?ii?aeiee o A?iieoeuee?e (0,21±0,03; ?<0,05) ? iaeiaioee - o Euea?anuee?e (0,13±0,01 iCa.??e-1; ?<0,001 a?aeiinii ??aiainueei? ? ?<0,05 a?aeiinii A?iieoeueei?). C 1995 ?ieo ??aaiue i?iiaiaaeo iaaaioaaeaiue o A?iieoeuee?e ? Euea?anuee?e iaeanoyo iiae?aiee. O cacia/aieo iaeanoyo c 1985 ii 1996 ??e c?inea /anoioa CAeA aaa?oieo. Iaea?eueoee ??no niinoa??aaany o ??aiainuee?e iaeano? – c 2,6±0,4% o 1985 aei 37,7±3,7% o 1996 ?ioe?, o A?iieoeuee?e iaeano? – c 7,5±0,5 aei 36,7±2,6% ? iaeiaioee ??no aeyaeany na?aae aaa?oieo Euea?anueei? iaeano? – c 7,4±0,6 aei 25,8±2,7%. ?ai?oa e?euee?noue aiai?? ca?eueoeeany o ??aiainuee?e iaeano? – o 1988 ?ioe? 4,5±0,7% ? ca aeaieie 1989 ?ieo - 10,3±1,8% (?<0,05). O A?iieoeuee?e iaeano? c?inoaiiy /anoioe aiai?? niinoa??aaee c 1990 ?ieo – c 7,8±0,8% o 1989 ?ioe? aei 11±1,1% (?<0,05). O Euea?anuee?e iaeano? – c 1991 ?ieo (9,9±1,2% ia a?aei?io a?ae 6±0,5% o 1990 ?ioe?; ?<0,05). Ca o?e ?iee (1994 – 1996) ??aaiue aiai?? na?aae aaa?oieo ??aiainueei? ? A?iieoeueei? iaeanoae aeyaeany iiae?aiei, a na?aae aaa?oieo Euea?anueei? iaeano? a??ia?aeii ieae/ei o ii??aiyii? c iieacieeaie aeaio ?ioeo iaeanoae. Ia i?eeeaae? A?iieoeueei? iaeano? i?iaaaeaii i?iaiicoaaiiy /anoioe aeieeiaiiy CAeA na?aae aaa?oieo a iaeaeeae/? /ioe?e ?iee, yea iaaaaeaii ia ?en. 1. A?aei?/aii oaiaeaioe?th aei i?iaeiaaeaiiy ?inoo oe??? iaoieia?? aaa?oiino?. ?en. 1 I?iaiic /anoioe aeieeiaiiy aiai?? na?aae aaa?oieo ca iaoa??aeaie A?iieoeueei? iaeano? (1985-1996) A?iieoeueea iaeanoue ii /anoio? aiai?? noiaea c ??aiainueeith, oi/a oa?eoi??y A?iieoeueei? iaeano? ia? iieacieee ?ii?coth/iai aei?ii?ithaaiiy a 10-15 ?ac?a iaio?, i?ae a ??aiainuee?e. Oei ia iaioa, o Euea?anuee?e iaeano?, aea ca 11 ?ie?a ia ci?ithaaany ?aae?aoe?eiee oii, ie oaeiae niinoa-??aa?ii cia/ia c?inoaiiy /enea aaa?oieo c aiai??th. Oaeei /eiii, ?aae?aoe?eia caa?oaeiaiiy oa?eoi??? neoaeeoue ni?eyoeeaei /eiieeii ?icaeoeo aiai?? aaa?oieo, aea ia iiynith? c?inoaiiy /enea oe??? iaoieia?? aaa?oiino? ca inoaii? ?iee. Iaeiaeiaa /anoioa aiai?? na?aae aaa?oieo A?iieoeueei? ? ??aiainueei? iaeanoae i?aeoaa?aeaeo? oaco i?i iani?eyoeeaee aieea eiiieaeno aeieia?/ieo /eiiee?a, eoaee aoiaeyoue ie??i ?ii?coth/iai aei?ii?ithaaiiy (?A) ?aa?iiaeuei? ae?iaie/? /eiieee, o?i?/i? aaaioe aio?iiiaaiiiai iioiaeaeaiiy, n?eueainio?i?y. Ii??aiyeueiee aiae?c nioe?aeueiiai iieiaeaiiy ? oaeoe/iiai oa?/oaaiiy aaa?oieo c aiai??th ? c o?c?ieia?/iei ia?aa?aii aaa?oiino? iieacaa, ui n?iaeiee i?eaooie o noi? a?ae 101 aei 300 a?i aoa iaeaea a iaeiaeia?e e?eueeino? n?iae (48,9 oa 55,7%; ?>0,05), oiae? ye, ii??aithth/e a?oie
na?aae aaa?oieo c CAeA, a?eueoee a?aenioie neeaaeaee n?i’? c
i?i?iaeueiei i?eaooeii, ia a?aei?io a?ae aaa?oieo c ii?iaeueiith
aaiia?aiith — c iaeneiaeueiei.

Ca nioe?aeueiei iieiaeaiiyi ?iciiae?e aaa?oieo iieacaa, ui o a?oi?
aaa?oieo aac aiai?? a?eueoa neoaeaiaoe?a (36,7 i?ioe 22,4%; ?<0,05) oa ?iai/eo ae?iaie/i? noa?e (10,1 ? 8,16%; ?=0,05), oiae? ye o I-e a?oi? a?eueoa nooaeaioie (18,4 oa 8,9%; ?<0,001). Ca?aae aaa?oieo c aiai??th a??ia?aeii a?eueoa ae?iie, ui oei/aniai ia i?aoeththoue - 18,4 ? 8,9% a?aeiia?aeii (?<0,05). Ioe?ithth/e ??aaiue o?ce/ieo iaaaioaaeaiue ae?iie, ie aeyaeee, ui na?aae aaa?oieo c aiai??th a?eueoa, i?ae o a?oi? ii??aiyiiy in?a o?ce/ii? i?aoe? (16,3 ? 7,6% a?aeiia?aeii; ?<0,05). E?euee?noue ae?iie, o yeeo ia?aaaaea? ?icoiiaa i?aoey, a iaio a?oiao iiae?aia - 63,3% a ?-e ? 72,2% o ??-e a?oi? (?>0,05).

E?euee?noue iaeeiieeo iaoa??a o I-e a?oi? iaea oaiaeaioe?th aei
ca?eueoaiiy (9,1 ? 7,5%; 0,05>?<0,1). O oe?e a?oi? a??ia?aeii a?eueoa iiaoi?ieo oetha?a. Oe?aeeea? cae/ee a?eueoa i?eoaiaii? ae?ieai ?c cae?ciaeao?oeeoiith aiai??th: iae?iiy a?aei?/athoue 30% aaa?oieo, iii??ia aaeeaaiiy aeeiaieth - 55% (o caei?iaeo a?aeiia?aeii - 14%; ?<0,05 oa 42%; ?<0,1). Eiioe?eoe a n?i’yo a?aecia/athoue 35% aaa?oieo c CAeA i?e 21% o caei?iaeo (?<0,05). sse iane?aeie, o 89% in?a c aiai??th aeyaeaia ae?ao?aeea?noue (i?e 20% o caei?iaeo, ?<0,05), ieaenea?noue, ?iceaae nio, a?ae/oooy iaaiaaiaiino?, o?eaiae, aeao?a (38% i?e 19% o a?oi? ii??aiyiiy; ?<0,05). Ii??aiyeueia ioe?iea aeaieo niiaoe/iiai aiaiiaco aeyaeea oaiaeaioe?th aei ca?eueoaiiy na?aae aaa?oieo c aiai??th ae?iie, ui oai??ee ia oai?iao Aioe?ia (12,2 i?ioe 5,1% na?aae ae?iie ??-? a?oie; ?<0,05), ?aaiaoeci (14,3 ? 5,1% a?aeiia?aeii; ?<0,05), o ?-e a?oi? aaa?oi? /ano?oa a?aei?/athoue aeiaaeee e?iaioa/? c ynai - 59% i?ioe 50,6% (?<0,1). Ca aeaieie aiaiiaco na?aaei?e a?e iiyae iaia?oa o ae?iie iniiaii? a?oie neeaaeaa 12,5±0,2 ?ie?a i?ioe 13,1±0,16 (?<0,05) - eiio?ieueii?. O?eaae?noue iaino?oaoe?? o ae?iie iaio a?oi iiae?aia (6,5±1,16 aei?a), ?yni? i?ny/i? na?aae oai?eo ia aiai?th aoee iaeaea o /ioe?e ?ace /ano?oa, i?ae o caei?iaeo (?<0,05). Ia?aianai? a?iaeieia?/i? caoai?thaaiiy a iaio a?oiao iiae?ai?, aea ie niinoa??aaee oaiaeaioe?th aei ca?eueoaiiy /anoioe o?ii?/ieo ai?eii-caiaeueieo caoai?thaaiue i?eaeaoe?a iaoee na?aae aaa?oieo c CAeA (28,6 i?ioe 20,3%; ?=0,05). I?ae /an oaia??oiuei? aaa?oiino? e?eoaaeueiith o?ceoeueoo?ith caeiaeeny 41% ae?iie c aiai??th oa 61% - caei?iaeo (?<0,05). ??aaiue o?ce/iiai iaaaioaaeaiiy i?ae /an aeae?aoii? a?aeionoee oa?aeoa?ecoaaee ye “aenieee” 23% oai?eo ia aiai?th, oa eeoa 4% caei?iaeo (?<0,05). No?ania? neooaoe?? ia i?ioyc? aaa?oiino? a?aei?/athoue 58% oai?eo ia aiai?th oa 48% caei?iaeo ae?iie (?<0,05). Iaea?eueo? ?ica?aeiino? aeyaeai? i?e ni?anoaaeaii? oaeoe/iiai oa?/oaaiiy aei ? i?ae /an aaa?oiino?. Na?aae aaa?oieo c aiai??th 41% ae?iie oa?/oaaeeny ia?aaoey?ii (na?aae caei?iaeo - 9%; ?<0,001), iniaeea?noth ?icii?yaeeo oa?/oaaiiy aaa?oieo iaio a?oi aeyaeany ia?a?iciiae?e aeaiiiai ?aoe?iio ca ?aooiie cia/ii? ia?aaaae ?aoe?iio aa/i?a iaae ?aieiaei. Oaeee ?aaeei oa?/oaaiiy caa??aaany i?e aaa?oiino? o 50% ae?iie I-? a?oie, o 40% - II-? (? = 0,05). Ci?ia oa?aeoa?o oa?/oaaiiy i?ae /an aaa?oiino?, a iniiaiiio, noinoaaeany i?aeaeuaiiy e?eueeino? ?ae? (81%), a ia ?? yeino? (19%), oa a?aeiiaith a?ae aeayeeo aeae?a i?iaeoeo?a (nieiaeiu?a, io/ieo, aino?eo). Aaa?oi? c aiai??th aaeeaathoue a??ia?aeii iaioa oeoe?o, i’yna, ?eae, ioeoe?, ne?o, y?oeue, oe?aa. Na?aae aaa?oieo c aiai??th 75% ae?iie aaeeaathoue ?ineeiieo aee??a a?eueoa, i?ae oaa?eiieo, ? 26,5% - ?ineeiieo i?iaeoeo?a (ea?oiiey, eaionoa, ao?ye, aa?aoc, oeeaoey, eaaa/ee) a?eueoa, i?ae oaa?eiieo (o caei?iaeo a?aeiia?aeii 53%, ?<0,05; 7,6%, ?<0,001). Oae? iai/?, ye ii?eaa, oiiaoe, aaeeaaeaie, aiaia? a?eueoa aaeeaathoue ae?iee eiio?ieueii? a?oie. Aiie ae a?eueoa aaeeaathoue ? o?oeo?a (98% i?e 86,9% na?aae aaa?oieo c aiai??th; ?<0,05). Ne?ae a?aecia/eoe, ui aenieee a?aenioie aaeeaaiiy yaeoe na?aae aaa?oieo c aiai??th (77,6%) coiiaeaiee aeio?eiaiiyi ?aeiiaiaeaoe?e aeooa??a i?ney anoaiiaeaiiy ae?aaiico aiai??. Ie??i oeueiai, aaa?oi? c aiai??th a?eueoa aaeeaathoue e?oi ? io/ieo ae?ia?a (ie??i oe?aa). Iaie a?aei?/aii, ui na?aae aaa?oieo c aiai??th iaiaaeaia ??ciiiai?oi?noue no?aa ? i?iaeoeo?a ? /ano?oa cono??/a?oueny aaeeaaiiy i?iaeoeo?a i?ney caa??aaiiy ? iiaoi?ii? eoe?ia?ii? ia?iaee. Iiaia a?aeiiaa a?ae aaeeaaiiy ia-/?iee ? ie?ie ao?e/? /ano?oa na?aae ae?iie ?-? a?oie, i?ae ??-? (14,3 ? 5,1% a?aeiia?aeii; ?<0,05); a?ae aaeeaaiiy oe?aa - o 20,4 ? 5,1% a?aeiia?aeii (?<0,05). I?e ?ic?aooieo niiaeeaaiiy iniiaieo oa?/iaeo i?iaeoeo?a a aaeao ie ioe?ieee oaeoe/ia oa?/oaaiiy aaa?oieo c aiai??th a 25,4 aaee, caei?iaeo aaa?oieo - a 33,6 aaee (?<0,05). Ii??aithth/e ia?aa?a aaa?oiino? ? iieia?a ca aeaieie ?noi??e iieia?a 163 aaa?oieo (? - iniiaia a?oia) c CAeA, ui iaoeathoue a i?no? c ??aiai o?i?/iiai oa ?aae?aoe?eiiai caa?oaeiaiiy, ui ia?aaeuo? ii?iaeuei? cia/aiiy, c aeaieie 102 aaa?oieo c CAeA (I a?oia - ii??aiyiiy) aeieia?/ii /enoiai ?aeiio A?iieoeueei? iaeano?, anoaiiaeaii aeaye? iniaeeaino? ia?aa?ao aaa?oiino? c CAeA a oiiaao ae?? aeieia?/ieo oaeoi??a. Oiae?, ye na?aae iaoeaiie i?noa aaea?/? a?eueoa ae?iie c aiai??th eaaeiai nooiaiy i?ae na?aaeiueiai (61,9 ? 31,3% a?aeiia?aeii; ?<0,05), oi na?aae iaoeaiie ?aeiio ie niinoa??aaee iiae?aio e?euee?noue aaa?oieo c eaaeei oa na?aaei?i nooiaiyie oyaeeino? aiai?? (55,4 ? 41,2% a?aeiia?aeii; ?>0,05).

Oneeaaeiaiee ia?aa?a aaa?oiino? cono??/aany /ano?oa na?aae iaoeaiie
i?noa – 77,3% ia a?aei?io a?ae iaoeaiie naea – 58,8% (?<0,05). Iae/ano?oeie oneeaaeiaiiyie ia?aa?ao aanoaoe?eiiai ia??iaeo a iaio a?oiao aeyaeeanue caa?ica iaaeiiooaaiiy aaa?oiino? ? i?a?eeaiin?y eaaeiai nooiaiy. Aea, ii??aithth/e oe? iieacieee ca a?oiaie, ie anoaiiaeee, ui na?aae aaa?oieo aeieia?/ii iani?eyoeeaiai i?noa i?aaeeaiin?y cono??/aeany a??ia?aeii /ano?oa, i?ae na?aae iaoeaiie aeieia?/ii /enoiai ?aeiio – 39,3 i?ioe 26,5% a?aeiia?aeii (?<0,05). Noiniaii caa?ice iaaeiiooaaiiy, oey iaoieia?y ii?aeioaaeany c CAeA /ano?oa o ae?oa?e a?oi?, i?ae o ia?o?e – 58,8 ? 41,1% a?aeiia?aeii (?<0,05). A iaio a?oiao aeyaeany a??ia?aeiei ei?aeyoe?eiee ca’ycie i?ae nooiaiai oyaeeino? i?aaeeaiin?? ? o?ii?/ii? oaoi-ieaoeaioa?ii? iaaeinoaoiino? (OOII) ? oyaee?noth aiai?? (r = 0,72 ? 0,64 o ia?o?e a?oi? oa r = 0,77 ? 0,60 o ae?oa?e a?aeiia?aeii). Aiae?coth/e ia?aa?a iieia?a a iaio a?oiao, ie anoaiiaeee, ui o 68,1% aaa?oieo ia?oi? a?oie ? o 62,7% ae?oai? iieiae aoee c oneeaaeiaiiyie (?>0,05). *ano?oa na?aae ae?iie aeieia?/ii caa?oaeiaiiai i?noa
niinoa??aaee aiiiae?? iieiaiai? ae?yeueiino?, i?ae na?aae aaa?oieo
aeieia?/ii /enoiai ?aeiio — o 21,5 ? 12,7% a?aeiia?aeii (?<0,05). O 15,3% iaoeaiie i?noa iieiae oa i?neyiieiaiaee ia??iae oneeaaeieeeny e?iaioa/ath, ia a?aei?io a?ae 10,8% - o ae?oa?e a?oi? (?<0,05). Oneeaaeiaiee ia?aa?a aaa?oiino? i?aeaeuo? /anoioo iia?aoeaieo ao?o/aiue, eio?? na?aae ae?iie ia?oi? a?oie neeaee 39,1%, a?aeiinii 28,4% o aaa?oieo ae?oai? a?oie (?<0,05). ??cieoey iieaciee?a ia?oi? ? ae?oai? a?oi neeaeanue, a iniiaiiio ca ?aooiie /ano?oiai canoinoaaiiy ?o/ii? ?aa?c?? ii?iaeieie iaoee na?aae ii?iae?eue ia?oi? a?oie – 18,3% (11,7% o ae?oa?e a?oi?; ?<0,05). I?e/eiaie aeey aeei?enoaiiy aeaii? iia?aoe?? aoee u?eueia i?ee??ieaiiy ieaoeaioe oa ?? aeaoaeoe. Oneeaaeiaiiy i?neyiieiaiaiai ia??iaeo /ano?oa cono??/aeeny na?aae ae?iie, oai?eo ia CAeA, ui iaoeathoue a aeieia?/ii iani?eyoeeaeo oiiaao – 32,5% i?e 26,7% na?aae ae?iie ae?oa?e a?oie (?<0,05). Naioe/i? oneeaaeiaiiy neeaee 16,2 ? 11,1% a?aeiia?aeii (?<0,05). *anoioa i?neyiieiaiaiai aiaeiiao?eoo a iaio a?oiao caeaaeaea a?ae nooiaiy oyaeeino? aiai??. Oneeaaeiaiiy aaa?oiino? ? iieia?a iaee iani?eyoeeaee aieea ia noai iiaiia?iaeaeaiiai. O ia?o?e a?oi? a 14,4% aeiaaee?a ae?oe ia?iaeaeoaaeeny o noai? ano?en?? ? 24,1% - c a?iio?io??th, oiae? ye o ae?oa?e a?oi? oe? iieacieee iaee oaiaeaioe?th aei cieaeaiiy – 11,1 ? 20,8% a?aeiia?aeii. Oaeei /eiii, aiai?y ? aaaeeei oneeaaeiaiiyi aaa?oiino? a oiiaao ae?? aeieia?/ii iaaacia/ieo oaeoi??a ? iani?eyoeeai aieeaa? ia noai ieiaea ? iiaiia?iaeaeaiiai, a oaeiae ? i?e/eiith oneeaaeiaiue i?ae /an iieia?a oa o i?neyiieiaiaiio ia??iae?. Iieacieee iai?io cae?ca o ae?iie iaaaaeai? a oaaeeoe? Oaaeeoey Iieacieee iai?io cae?ca a i?aai?ci? ae?iee aei ? i?ae /an aaa?oiino? I?ei?oea. Iicia/ea * icia/a?, ui ??cieoey aeinoia??ia (*-?<0,05; **-?<0,001) ii a?aeiioaiith aei iieaciee?a ia?oiai o?eiano?o. Iiaeaeueoee aiae?c io?eiaieo aeaieo iieacaa, ui na?aae iaaaa?oieo ae?iie o 16% ??aaiue aaiiaeia?io ieae/a 110 a/e. A oe?e a?oi? ae?iie cieaeaia na?aaeiy e?euee?noue a?eo?ioeeo?a (3,2±0,12 o106e3), eiioeaio?aoe?y cae?ca ne?iaaoee neeaea 18,7±1,35 ieiieue/e. Ii?iaeueiee ??aaiue NC cono??/aany o 65% iaaaa?oieo ae?iie, aea eiai ii?aeiaiiy c ii?iaeueiith eiioeaio?aoe??th aaiiaeia?io a?aecia/aii eeoa o 60% aeiaaee?a. Oey a?oia a?aeiinii cae?ciaeao?oeeoii? aiai?? aaaaea?oueny caei?iaith. Aiae?coth/e noai aeaii ca-e?ca na?aae oeeo ae?iie, ie anoaiiaeee, ui na?aaei?e ai?no NO neeaa 45,28 ± 9,1 iea/e, c eieeaaiiyie a?ae 6,5 aei 242 iea/e. I?e oaeiio ??ai? oa?eoeio na?aaeiy eiioeaio?aoe?y aaiiaeia?io aei??aithaaea 121,8 ± 0,23 a/e, NC - 20,8 ± 1,18 ieiieue/e, i?e IO - 37,3 ± 2,15% ? CNCC- 55,8 ± 1 ieiieue/e. An? oe? aaee/eie oa?aeoa?ecothoue ii?iaeueiee iai?i cae?ca a i?aai?ci?. O 35% iaaaa?oieo ae?iie ??aaiue cae?ca ne?iaaoee aoa ieae/a ii?ie ? neeaaeaa 8,6 ± 1,08 ieiieue/e, o 2/3 c ieo n?aea?iiai?y noi?iaiaeaeoaaeanue iaae?iiyi ??aiy aaiiaeia?io oa e?eueeino? a?eo?ioeeo?a. Eaoaioia n?aea?iiai?y noi?iaiaeaeoaaeany ii?iaeueiei ??aiai inoaii?o aeaio iieaciee?a, aea na?aaei? cia/aiiy NO neeaei 24,8 ± 5,3 iea/e, c i?i?iaeueiei cia/aiiyi 2,0 ? iaeneiaeueiei 75,5 iea/e. A oe?e a?oi? cieaeaiee eiao?oe??io iane/aiiy o?ainoa?eio - 13,7 ± 0,4%, ? CCNCC - 28,65 ± 0,76 ieiieue/e. Iai?oanoia aiai?y, ia a?aei?io a?ae eaoaioii? n?aea?iiai??, noi?iaiaeaeoaaeany cieaeaiiyi eiioeaio?aoe?eieo iieaciee?a /a?aiii? e?ia? ? iiaeeaeaiiyi ii?ooaiue iai?io cae?ca - na?aaei?e ai?no oa?eoeio cieceany aei 17,9±1,6 iea/e, NC - aei 4,9±0,45 ieiieue/e, eiao?oe??ioo iane/aiiy o?ainoa?eio - aei 12,5±1,1%, a CCNCC i?aeaeueeany aei 43,7 ± 8 ieiieue/e. Ioe?ithth/e iieacieee an??? a?oie iaaaa?oieo ae?iie ?ai?iaeoeoeaiiai a?eo, ie anoaiiaeee, ui c ieo 72% iathoue ??aaiue NO iaioa ieaeiuei? iaae? ii?ie - 45,5±4,58 iea/e (na?aaei? cia/aiiy - 19,96±1,95 iea/e). Na?aae 42 ae?iie, ianoaaeaieo o ia?oiio o?eiano?? aaa?oiino?, iieacieee iai?io cae?ca nooo?ai ia a?ae??ciyeeny a?ae iieaciee?a o iaaaa?oieo. Na?aaeiy eiioeaio?aoe?y aaiiaeia?io neeaea a ia?oiio o?eiano?? - 114±2,1 a/e, o iaaaa?oieo 117,3±0,19 a/e (?>0,05). E?euee?noue
a?eo?ioeeo?a — 3,5±0,4 O1012/e ? 3,9 ± 0,05 O1012/e a?aeiia?aeii
(?>0,05). Ia a?ae??ciyeenue ? a?eo?ioeeoa?i? ?iaeaene: MCV o iaaaa?oieo
— 88,9±1,14 i?e?ii3, o ia?oiio o?eiano?? — 87,2±2,18 i?e?ii3 (?>0,05);
MCH — 30,3±0,4 ? 31,3±1,2 ia a?aeiia?aeii (?>0,05); MCHC — 34,3±0,6%
aeey iaaaa?oieo ? 34,2±1,1% aeey aaa?oieo o ia?oiio o?eiano?? (?>0,05).

Ii??aithth/e ??aaiue cae?ca ne?iaaoee oa ia’?ie aeaiiiiaaiiai cae?ca, ie
ia aeyaeee a??ia?aeii? ??cieoe? i?ae eiioeaio?aoe??th NC aei aaa?oiino?
e a ?aii? oa?i?ie — 15,6±1,3 ? 12,4±0,8 ieiieue/e a?aeiia?aeii (?>0,05).
Aea, yeui ??aaiue oa?eoeio aei aaa?oiino? — 38,6± 5,9 iea/e, oi
iai?ee?ioe? ia?oiai o?eiano?o ie niinoa??aaee oaiaeaioe?th aei cieaeaiiy
ia’?io aeaiiiiaaiiai cae?ca — NO neeaa 23,4±2,2 iea/e (?<0,05). Oey ea?oeia a?aeaeca?eaeth? i?ioean aeei?enoaiiy cae?ca ?c i?aai?a-aeaii ia iio?aae i?aai?cio iaoa?? ? ieiaea. O ia?oiio o?eiano?? ua ia ianooiaee ci?ie iieaciee?a aaiia?aie (eeoa o 8 in?a (19%) ??aaiue aaiiaeia?io aoa ieae/a, i?ae 110 a/e, (114±2,1 a/e) ? niinoa??aaany ii?iaeueiee ??aaiue NC ii?yae c eiao?oe??ioii iane/aiiy o?ainoa?eio (aei aaa?oiino? - 32,2±1,04%, o ia?oiio o?eiano?? - 34,1±2,4%; ?>0,05), ui ? “aeeiai?/ieie” ? “o?aiceoieie” iieacieeaie, ?
oa?aeoa?ecothoue eeoa oei/aniao aaeaeaaoi?noue ia’?io cae?ca a i?aai?ci?
ae?iee ca ?aooiie iayaiino? aeaiiiiaaiiai cae?ca.

O ia?oiio o?eiano?? ie niinoa??aaee oaeiae oaiaeaioe?th aei cieaeaiiy
aaiaoie??oo ii??aiyii c eiai cia/aiiyi o iaaaa?oieo (29,3±1,3 ?
34,6±0,6% a?aeiia?aeii; ?=0,05), ui a?aeia?aaea? ii/aoie i?ioeano
a?ae?ai??.

I?e i?ia?anoaaii? aaa?oiino? iiaeeaeththoueny ci?ie iai?io cae?ca. A
ia?oo /a?ao oea i?iyaey?oueny ??ceei iaae?iiyi iai?ee?ioe? ae?oaiai
o?eiano?o ??aiy NO aei 9,3±2,3 iea/e (ia a?aei?io a?ae 23,4±2,2 iea/e o
ia?oiio o?eiano??; ?<0,01), NC - aei 9,09±2,2 ieiieue/e (o ia?oiio o?eiano?? - 12,4±0,8 ieiieue/e; ?<0,05), iane/aiiy o?ainoa?eio cae?cii cieceeinue o ia?oiio o?eiano?? c 34,1±2,4% aei 29,4±1,7% o ae?oaiio (?<0,05). Oe? iane?aeee ae/a?iaiiy aeaii cae?ca i?ecaaee aei ci?i o ia?eoa??ei?e eaioe? /a?aiii? e?ia? - ??aaiue aaiiaeia?io neeaa 93,58±4,3 a/e ia a?aei?io a?ae 114±2,1 a/e o ?aii? oa?i?ie aaa?oiino? (0,050,05) ? NC — 9,09±2,2 ieiieue/e o ae?oaiio
o?eiano?? ? 9,13±1,64 ieiieue/e iai?ee?ioe? o?aoueiai (?>0,05).
I?i?iaeueia cia/aiiy NO o a?oi? ianoaaeaieo ia?aae iieiaaie neeaei 2,2
iea/e, a iaeneiaeueia — 13,3 iea/e. Oea iciaee aeaeiiiainaoe?? iai?io
cae?ca ? iiaiiai ae/a?iaiiy eiai caian?a a i?aai?ci? aaa?oii?,
aiane?aeie /iai a?aeaoaathoueny no?ee? ci?ie ia?eoa??eii? eaiee /a?aiii?
e?ia?: e?euee?noue ae?iie c CAeA ? nooiaiy oyaeeino? neeaea 57,6%, ??
nooiaiy — 3%. Ia iiaeeaeaiiy aeao?oeeoo cae?ca aeaco? ? i?aeaeuaiiy
??aiy ECNCC c 50,81±6,7 ieiieue/e o ae?oaiio o?eiano?? aei 66,6±4,92
ieiieue/e (?<0,05); ICNCC ia ci?ieeany (73,24±7,2 ? 79,65±2,9 ieiieue/e; ?>0,05).

Aecia/ath/e oe?ii?noue on?o eaai?aoi?ieo iieaciee?a /a?aiii? e?ia? aeey
oa?aeoa?enoeee aeaii cae?ca, ie anoaiiaeee, ui aenieee ei?aeyoe?eiee
ca’ycie c ??aiai ne?iaaoeiaiai oa?eoeio, ie??i aaiiaeia?io, a?eo?ioeeo?a
? aaiaoie??oo ia? ?ici?? cae?aiino? ne?iaaoee ca’ycoaaoe cae?ci,
na?aaeiy eiioeaio?aoe?y ? na?aaei?e ai?no aaiiaeia?io a a?eo?ioeeo?. Ui
noino?oueny ne?iaaoeiaiai cae?ca, oi c ?ooeiieie ?iaeeeaoi?aie /a?aiii?
e?ia? (aaiiaeia?i, a?eo?ioeeoe ? aaiaoie??o) ei?aeyoe?eiee ca’ycie
aeyaeany aeoaea iecueeei.

Oaeei /eiii, ie aeyaeee, ui iai?oanoi?e aiai?? i?ae /an aaa?oiino?
ia?aaeothoue eaoaioi? ii?ooaiiy iai?io cae?ca — i?aaiai?y. Iao?
niinoa?aaeaiiy iieacothoue, ui ??aaiue aaiiaeia?io ? ne?iaaoeiaiai
cae?ca ia iiaeooue neoaeeoe e?eoa??yie aeey ioe?iee eiai caian?a a
i?aai?ci?. A?eueo a??ia?aeiei aeey ioe?iee caian?a cae?ca ? aeey
i?iaiico ?icaeoeo aiai?? ? aecia/aiiy ai?noo oa?eoeio a e?ia?. O
no/ani?e e?oa?aoo?? iaia? ?aeeii? aeoiee i?i ii?iaia? cia/aiiy NO. sseui
?aooaaoe aaeaeaaoiei ??aaiue NO a?eueoa 200 iea/e, oi, ye iieacaei iaoa
aeine?aeaeaiiy, i?e 40 iea/e aei aaa?oiino? iaieio/a aeniaaeaiiy caian?a
cae?ca o II — III o?eiano??, a i?e NO iaioa 20 iea/e ?icaeaa?oueny CAeA.
Ie aaaaea?ii, ui aaee/eio NO aei 50 iea/e iiaeia iacaaoe i?eoiaaiei
aeao?oeeoii cae?ca – cae?ciaeao?oeeoiei noaiii (i?aaiai?y), a iaioa 20
iea/e — e?eoe/iei ??aiai, i?ney /iai cieaeo?oueny ??aaiue aaiiaeia?io ?
e?euee?noue a?eo?ioeeo?a.

I?eeiyoa nueiaiaei? i?ecia/aiiy i?aia?ao?a cae?ca c iiiaioo cieaeaiiy
iieaciee?a /a?aiii? e?ia? iaaeinoaoiuei aoaeoeaii oiio, ui aei oeueiai
a?aeaoaathoueny eaoaioi? ci?ie iai?io cae?ca. Oaiie ?icaeoeo aiai??
caeaaeaoue a?ae iiaiioe?iiino? aeaii ia /an caie?aeiaiiy. Oiio ?aiiy
ae?aaiinoeea cae?ciaeao?oeeoo (i?aaiai??) ? ioe?iea aaeaeaaoiino?
caian?a cae?ca aeicaieyoue o ?aii? oa?i?ie aaa?oiino? eiiiainoaaoe
cae?ciaeao?oeeoiee noai ? a?aeaa?iooe ?icaeoie iai?oanoiiai
cae?ciaeao?oeeoo — CAeA.

Aeoiaey/e c oeueiai, iaie aoea i?iaaaeaia ii??aiyeueia ioe?iea
aoaeoeaiino? iiiiaiaiiy caian?a cae?ca i?ecia/aiiyi ae?ieai ia?oi? a?oie
i?aa-i?/ii? nie? — aetheiiaoo cae?ca (a neeaae? i?aia?aoo Oioaia) ? a
ae?oa?e a?oi? iai?aai?/ii? — noeueoaoo cae?ca (Aeoeoa?ei) a ?aii?
oa?i?ie aanoaoe?? aeey i?io?eaeoeee ?icaeoeo CAeA aaa?oieo.

I?ney i?iaaaeaiiai e?eoaaiiy iieacieee /a?aiii? e?ia? caeeoaeeny a
iaaeao ii?ie o?eueee i?e aeei?enoaii? i?aia?aoo Oioaia. O ae?iie, ui
i?eeiaee Aeoeoa?ei, iinooiiai c?inoaee ci?ie, ui na?ae/eoue i?i
i?ia?anoaaiiy cae?ciaeao?oeeoiiai noaio, oi/a yaii? aiai?? ua ia
niinoa??aaeiny.

I?e??no iniiaieo iieaciee?a iai?io cae?ca a?aeia?aaeaii ia ?en. 2.

?en 2. I?e??no iniiaieo iieaciee?a iai?io cae?ca i?ney e?eoaaiiy

O ia?oo /a?ao, iaie a?aei?/aiee i?e??no ??aiy NO o ae?iie, ye?
io?eioaaee Oioaio, ia a?aei?io a?ae oaeiai o ae?iie, eio?? i?eeiaee
Aeoeoa?ei – 24,2±2,4 iea/e oa 10,1±1,5 iea/e a?aeiia?aeii (?<0,05). Aeinoia??ii ?ic??ciyany ? ??aaiue iane/aiiy o?ainoa?eio cae?cii (36,8% a ia?o?e ia a?aei?io a?ae 20,5% a ae?oa?e; ?<0,05) oa e?euee?noue NC (22,1 ieiieue/e ? 10,1 ieiieue/e a?aeiia?aeii; ?<0,05). Ana oea na?ae/eoue i?i e?ea?aeaoe?th cae?ciaeao?oeeoiiai noaio i?ae aieeaii Oioaie, /iai ia a?aeaoaa?oueny i?e e?eoaaii? Aeoeoa?eiii. Iaea??o? iieacieee cao?eniaai? iaie o ae?iie eiio?ieueii? a?oie (ci?ia ia?eoa??eii? eaiee /a?aiii? e?ia?), ye? acaaae? ia io?eioaaee i?aia?ao?a cae?ca. Iiaeaeueo? aeine?aeaeaiiy iieacaee, ui i?ney aaeeaaiiy i?aa-i?/ieo i?aia?ao?a cae?ca o 19,8% ae?iie ia?aae iieiaaie ?icaeaa?oueny aiai?y ia?oiai nooiaiy, i?e canoinoaaii? iai?aai?/iiai cae?ca aiai?y iaea i?noea o 30,9% aeiaaee?a. Iaeaeuee iieaciee aiai?? niinoa??aaany o ae?iie, yeei ia i?ecia/aee i?aia?aoe cae?ca – 62,2%. Oaeei /eiii, aeyaeeinue aoaeoeaiei canoinoaaiiy i?aia?aoo “Oioaia” aeey e?eoaaiiy cae?ciaeao?oeeoo, ui ? i?io?eaeoeeith ?icaeoeo oyaeei? aiai?? /a?ac iinooiiaa aeniaaeaiiy aeaii cae?ca. AENIIAEE 1. Cae?ciaeao?oeeoia aiai?y aaa?oieo - aaaeea, oe?iei ?iciianthaeaeaia oneeaaeiaiiy aanoaoe?eiiai i?ioeano, cono??/a?oueny aei 70-80% aeiaaee?a ? a ianooii? 4 ?iee eiia??ii i?ia?aneaii c?inoa ?? /anoioa. 2. *eiieeaie ?inoo /anoioe cae?ciaeao?oeeoii? aiai?? na?aae aaa?oieo ca inoaii? ?iee ? iia??oaiiy aeieia?/iiai noaio ioi/oth/iai na?aaeiaeua aio?iiiaaiiiai iioiaeaeaiiy, ia?aoe?iiaeueia ? iaiiaiioe?iia oa?/oaaiiy aaa?oieo, oe?aeeea? cae/ee, o?ce/i? ? ineo?/i? ia?aaaioaaeaiiy ye iane?aeie nioe?aeueii-aeiiii?/ieo i?iaeai. 3. Cae?ciaeao?oeeoia aiai?y aaa?oieo - inoaiiy noaae?y aeeiai?/ieo ci?i iai?io cae?ca, ui aeieeathoue i?ney caie?aeiaiiy, ? a?aeia?aaea? c?ea eiiiainaoi?ieo ?aaeoe?e iai?io cae?ca. ?e ia?aaeo? aeniaaeaiiy aeaii cae?ca (cae?ciaeao?oeeoiee noai), i?i ui na?ae/?oue cieaeaiiy ne?iaaoeiaiai oa?eoeio ieae/a 40-50 iea/e. 4. Aei??thaaiiy oa?eoeio ne?iaaoee aeey ae?aaiinoeee cae?ciaeao?oeeoiiai noaio - iaae?eiee iaoiae aeiee?i?/ii? ae?aaiinoeee ?icaeoeo CAeA. 5. I?io?eaeoeeo oa e?eoaaiiy CAeA aaa?oieo aeioe?eueii ii/eiaoe aaciina?aaeiuei i?ney ae?aaiinooaaiiy cae?ciaeao?oeeoiiai noaio, ui a a?eueoino? aeiaaee?a caiia?aa? ?icaeoeo ee?i?/ieo i?iya?a CAeA a a ?ac? i?ia?anoaaiiy aiai?? aeeeth/a? iayai?noue oyaeeeo ?? oi?i. 6. I?ecia/aiiy a ?aii? oa?i?ie aaa?oiino? aetheiiaoo cae?ca (Oioaia) aei ?icaeoeo ee?i?/ieo i?iya?a CAeA aeicaiey? i?aeaeueoe ??aaiue aeaiiiiaaiiai cae?ca ? ia?aoeiaeaea? iaae?iith ??aiy aaiiaeia?io oa a?eo?ioeeo?a i?e i?ia?anoaaii? aaa?oiino?. I?ney aaeeaaiiy i?aia?aoo Oioaia o 19,8% ae?iie ia?aae iieiaaie ?icaeaa?oueny aiai?y ia?oiai nooiaiy, i?e canoinoaaii? noeueoaoo cae?ca (Aeoeoa?ei), aiai?y ia? i?noea o 30,9% aeiaaee?a. Iaeaeuee iieaciee aiai?? niinoa??aa?oueny o ae?iie, ye? ia i?eeiaee i?aia?ao?a cae?ca – 62,2%. NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Aieea aiai?? ia ia?aa?a aaa?oiino?, iieia?a ? noai iiaiia?iaeaeaiiai o ae?iie, ui i?iaeeaathoue o ciiao ?aae?iaeoeaiiai caa?oaeiaiiy // A?niee i?iaeai iaaee/ii? ?aaa?e?oaoe?? oa o?c?ioa?ai??.-1997.- ?2-3.- Aeione 2.- N. 133-134 (ni?aaao.: Eieiae?e I.?., Iaci?/oe A.O., E?aia?aiei I.I.). 2. Aeaye? aaiiaeeiai?/i? oa aai?/i? iieacieee o oai?eo c iaaeiiooaaiiyi aaa?oiino? ia oii? a?ia?oii?/ii? oai?iae a ii?aeiaii? c aiai??th // Iaaeiiooaaiiy aaa?oiino? (Ca. iaoe. i?. “Iaaeiiooaaiiy aaa?oiino?” (ia?oa iaoeiai-i?aeoe/ia eiioa?aioe?y Anioe?aoe?? aeooa??a-a?iaeieia?a Oe?a?ie).-E.,1997.-96n. (ni?aaao.: Aei?no?yinueea A.I., Iaci?/oe A.O.). 3. Aeieia?/i? aniaeoe aioo?eoiueioo?iaii? a?iien?? ieiaea i?e cae?ciaeao?oeeoi?e aiai?? aaa?oieo //I?ioa?aiey. Aeieeaaeu Aeaaeaiee i?iaeai aeiienee.-Oii 2.-E.:IEIOe “Ii?o” IAI Oe?aeiu.-1998.- N.140-141(ni?aaao.: sseiaeaaa I.A., Iaci?/oe A.O.). 4. Aeaye? aeieia?/i? aniaeoe i?iaeaie aiai?? aaa?oieo //Oace aeiiia?aeae Ae?oaiai I?aeia?iaeiiai eiia?ano nooaeaio?a ? iieiaeeo a/aieo.- Oa?iii?eue.-1998.- N.325 (ni?aaao.:Iaci?/oe I.A.). 5. I?i iiaeeea? i?e/eie c?inoaiiy /anoioe aiai?? na?aae aaa?oieo // Ia-ae?ao??y, aeooa?noai oa a?iaeieia?y.-1999.-?1.- N.77-79 (ni?aaao.: Iaci?/oe A.O.). 6. Ii?aaeaeaiea o?iaiy aeaiiie?iaaiiiai aeaeaca a i?aaiecia iaaa?aiaiiuo aeaiuei, eae i?iaiinoe/aneee e?eoa?ee ?acaeoey aeaeaciaeaoeoeeoiie aiaiee ai a?aiy aa?aiaiiinoe // A?niee Anioe?aoe?? aeooa??a-a?iaeieia?a Oe?a?ie.-1999.-?2.- N. 64-67 (ni?aaao.: Iaci?/oe A.O.). 7. Aeaye? aniaeoe i?iaeaie eana?nueeiai ?icoeio na?aae aaa?oieo c aiai??th // A?niee A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.-1999.-?3(1).- N. 105-106. 8. Aeaye? aniaeoe ia?aa?ao aaa?oiino? oa iieia?a o ae?iie c ii?aeiaiiyi aiai?? aaa?oieo ? i?ci?i aanoicii // E?ea?nueea ni?aaa.- 1999.- ?3 (1045).- N. 132-133 (ni?aaao. Eai?inueeee A.A., AEoe N.?.) 9. Ae?iaioa?i? oa nioe?aeuei? aniaeoe ?inoo /anoioe cae?ciaeao?oeeoii? aiai?? na?aae aaa?oieo // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.-1999.-?4.- N.199-201 (ni?aaao.: Iaci?/oe A.O.). 10. Ii??aiyeueia ioe?iea aoaeoeaiino? canoinoaaiiy i?aai?/ii? oa iai?aai?/ii? nie? cae?ca aeey e?eoaaiiy cae?ciaeao?oeeoo oa i?io?eaeoeee cae?ciaeao?oeeoii? aiai?? aaa?oieo // Oa?iaoeaaoe/iee aeo?iae.- 1999.- ? 5.- N. 99-103 (ni?aaao. Iaci?/oe A.O, sseiaeaaa I.I.). AIIOAOe?ss I?ioeaiei I.I. I?iaiicoaaiiy oa i?io?eaeoeea cae?ciaeao?oeeoii? aiai?? o aaa?oieo, ui i?iaeeaathoue a aeieia?/ii iani?eyoeeaeo oiiaao. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 - aeooa?noai ? a?iaeieia?y. A?iieoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao ?i. I.?.Ie?iaiaa IIC Oe?a?ie, A?iieoey, 1999?. Aeena?oaoe?th i?enay/aii ieoaiiyi i?i ?iciianthaeaeaiiy, i?e/eie ?inoo ? oaeoi?e ?eceeo aeieeiaiiy CAeA aaa?oieo o no/anieo oiiaao. A aeena?oaoe?? ia iniia? aea/aiiy iniaeeainoae iai?io cae?ca i?e i?ia?anoaaii? aaa?oiino? ?ic?iaeaii iiaee i?aeo?ae aei i?io?eaeoeee CAeA. Anoaiiaeaii, ui cae?ciaeao?oeeoia aiai?y aaa?oieo - noaae?y c?eao eiiiainaoi?ieo aeeiai?/ieo ci?i iai?io cae?ca i?ney caie?aeiaiiy. Aiai?? ia?aaeo? cae?ciaeao?oeeoiee noai (i?aaiai?y - aeniaaeaiiy aeaii cae?ca) i?i ui na?ae/eoue cieaeaiiy ne?iaaoeiaiai oa?eoeio ieae/a 40-50 iea/e. Aeey i?io?eaeoeee CAeA aaa?oieo o ?aii? oa?i?ie canoinoaaiiy i?aai?/ii? nie? cae?ca (aetheiiaoo) o neeaae? i?aia?aoo “Oioaia” aeyaeeinue aoaeoeai?oei, i?ae iai?aai?/ii? (noeueoao cae?ca) a neeaae? i?aia?aoo “Aeoeoa?ei”. I?ecia/aiiy aetheiiaoo cae?ca i?ney anoaiiaeaiiy cae?ciaeao?oeeoiiai noaio ua aei ?icaeoeo ee?i?/ieo i?iya?a CAeA aeicaiey? i?aeaeueoe ??aaiue aeaiiiiaaiiai cae?ca ? ia?aoeiaeaea? cieaeaiith ??aiy aaiiaeia?io oa a?eo?ioeeo?a i?e i?ia?anoaaii? aaa?oiino?. Eeth/ia? neiaa: cae?ciaeao?oeeoia aiai?y aaa?oieo, ai?aeai?ieia?y, i?e/eie, ne?iaaoeiaee oa?eoei, iai?i cae?ca, e?eoaaiiy. AIIIOAOeEss I?ioeaiei A.A. I?iaiice?iaaiea e i?ioeeaeoeea aeaeaciaeaoeoeeoiie aiaiee aa?aiaiiuo, i?iaeeaathueo a yeieiae/anee iaaeaaii?eyoiuo oneiaeyo. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 - aeooa?noai e aeiaeieiaey. Aeiieoeeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao ei. I.E.Ie?iaiaa IC Oe?aeiu, Aeiieoea, 1999a. Aeenna?oaoeey iinayuaia aii?inai ?ani?ino?aiaiey, i?e/eiai ?inoa e oaeoi?ai ?enea ?acaeoey aeaeaciaeaoeoeeoiie aiaiee n?aaee aa?aiaiiuo, i?iaeeaathueo a oneiaeyo aeaenoaey eiiece?othuaai eceo/aiey, oeie/aneiai caa?yciaiey aoiinoa?iiai aicaeooa, ii/au, aiaeu i?iiuoeaiiuie, o?ainii?oiuie i?iaeoeoaie caa?yciaiey e i?iaeoeoaie naeueoicoeiee. A aeenna?oaoeee, ia iniiaa eco/aiey iniaaiiinoae iaiaia aeaeaca ii ia?a i?ia?anne?iaaiey aa?aiaiiinoe, ?ac?aaioai iiaue iiaeoiae e i?ioeeaeoeea AEAeA. Onoaiiaeaii, /oi AEAeA ano?a/aaony aei 70-80% n?aaee aa?aiaiiuo, i?iaeeaathueo a ai?iaea, a n?aaeiaiaeanoiua iieacaoaee aeey Aeiieoeeie iaeanoe aic?inee n 7,2±0,49% a 1985a aei 35,7±1,2% a 1996 a, aeey ?iaaineie - n 3,7±1,02 aei 37,7±1,7%, Eueaianeie - n 6,5±0,82 aei 25,8±2,1%. Ii aeaiiui i?iaiica, a aeeaeaeoea /aou?a aiaea ioia/aia oaiaeaioeey ?inoa /anoiou AEAeA n?aaee aa?aiaiiuo. Ii iaoei aeaiiui, ?aaeeiaeoeaiia caa?yciaiea oa??eoi?ee neoaeeo niinianoaothuei oaeoi?ii aiaiee aa?aiaiiuo, ii ia iauyniyao ?ino /enea yoie iaoieiaee aa?aiaiiinoe ca iineaaeiea aiaeu. Iaeeiaeiaay /anoioa aiaiee n?aaee aa?aiaiiuo Aeiieoeeie e ?iaaineie iaeanoae iiaeoaa?aeaeaao oacen i iaaeaaii?eyoiii aicaeaenoaee eiiieaena yeieiae/aneeo oaeoi?ia, eoaea aoiaeyo iiieii eiiece?othuaai eceo/aiey (EE) ?aaeiiaeueiua i?iecaiaenoaaiiua oaeoi?u, naeueoicoeiey. O/eouaay oe?ieia ?ani?ino?aiaiea aiaiee, iu i?iaiaeece?iaaee aa aeeyiea ia oa/aiea aanoaoeeiiiiai i?ioeanna o aeaiuei, i?iaeeaathueo a yeieiae/anee iaaeaaii?eyoiuo oneiaeyo, e onoaiiaeee, /oi ineiaeiaiiia oa/aiea aa?aiaiiinoe e ?iaeia eiaei ianoi o 77,3% aeaiuei (i?ioea 58,8 % a a?oiia aa?aiaiiuo, i?iaeeaathueo ia oa??eoi?ee, aaea oeie/aneea aauanoaa e o?iaaiue EE ia i?aauoatho i?aaeaeueii aeiionoeiua eiioeaio?aoeee). N?aaieoaeueiue aiaeec aeaiiuo aiaiiaca, nioeeaeueiiai iieiaeaiey e oaeoe/aneiai ieoaiey aa?aiaiiuo n aiaieae e n oeceieiae/aneei oa/aieai aa?aiaiiinoe iieacae, /oi a ia?aie a?oiia /aua ano?a/athony aa?aiaiiua a aic?anoa 20-25 eao, ia?aiaa?aiaiiua ia?ai?iaeyuea, iiaoi?ii?iaeyuea n?aaee iiaoi?iiaa?aiaiiuo. O aeaiuei n AEAeA a aiaiiaca aieueoa ?iaeia e ei?i/a eioa?aae iaaeaeo aa?aiaiiinoyie. Oaeoi?aie, niinianoaothueie ?acaeoeth AEAeA ai a?aiy aa?aiaiiinoe, ieacaeenue ineoi-yiioeeiiaeueiua iaa?ocee, a?aaeiua i?eau/ee, ?aaiaoeci, aieaciue Aioeeia, e?iaioa/aiey ec aeanai, iaeeueiua iany/iua. E aiciiaeiui i?e/eiai, aucaaaoei ?ino aiaiee n?aaee aa?aiaiiuo ca iineaaeiea 10 eao, ioiinyony aeeiaioa?iua oaeoi?u: ia?aaoey?iia e iaiieiioeaiiia ieoaiea, ca n/ao /aai a i?aaieci aa?aiaiiie ia iinooiaao aeinoaoi/iia eiee/anoai ia oieueei aeaeaca, ii e iniiaiuo eiiiiiaioia - aaeeia, aee?ia, oaeaaiaeia, aeoaieiia, nieae. A?oiio ?enea ninoaaeytho aeaiueiu n iaaeaaii?eyoiui iaania/aieai naiuee (aac?aaioiua, nooaeaiou, iaeeiieea iaoa?e), a /ai ninoieo nioeeaeueii-yeiiiie/aneee aniaeo AEAeA aa?aiaiiuo. Ii ?acoeueoaoai aiaeeca eciaiaiee iaiaia aeaeaca ii ia?a i?ia?anne?iaaiey aa?aiaiiinoe iaie onoaiiaeaii, /oi aeaeaciaeaoeoeeoiay aiaiey aa?aiaiiuo - noaaeey n?uaa eiiiainaoi?iuo aeeiaie/aneeo eciaiaiee iaiaia aeaeaca, ?acaeaathueony n ianooieaieai aa?aiaiiinoe e nooue eioi?uo ninoieo a iinoaiaiiii en/a?iaiee caiania aeaeaca a i?aaiao-aeaii. Iaieoanoiie aiaiee i?aaeoanoaoao aeaeaciaeaoeoeeoiia ninoiyiea - enoiuaiea aeaii, i /ai naeaeaoaeuenoaoao nieaeaiea nuai?ioi/iiai oa??eoeia aei 40-50 iea/e. Aeey ?acaeoey AEAeA eiaao cia/aiea ia?aiia/aeueiue o?iaaiue aeaiiie?iaaiiiai aeaeaca e iauaiu iinooieaiey aeaeaca n ieoaieai. O 72% iaaa?aiaiiuo aeaiuei aeaoi?iaeiiai aic?anoa iu aeeaaiinoe?iaaee aeaeaciaeaoeoeeoiia ninoiyiea (aaee/eia NO iaiueoa 40-50 iea/e). I?e onoaiiaeaiee nieaeaiey o?iaiy aeaiiie?iaaiiiai aeaeaca a ?aiiea n?iee aa?aiaiiinoe iaiaoiaeeii aaaaeaiea aai a i?aaieci. Aeey ea/aiey aeaeaciaeaoeoeeoiiai ninoiyiey o aa?aiaiiuo eniieueciaaiea i?aaie/aneie niee aeaeaca (aetheiiaoa) a ninoaaa i?aia?aoa Oioaia ieacaeinue yooaeoeaiaa, /ai iai?aaie/aneie (noeueoaoa aeaeaca) a ninoaaa i?aia?aoa Aeoeoa??ei. Iacia/aiea aetheiiaoa aeaeaca iinea auyaeaiey aeaeaciaeaoeoeeoiiai ninoiyiey aei ?acaeoey eeeie/aneeo i?iyaeaiee AEAeA iicaieyao iiauneoue o?iaaiue aeaiiie?iaaiiiai aeaeaca e i?aaeioa?aoeoue iaaeaiea o?iaiy aaiiaeiaeia e y?eo?ioeeoia ii ia?a i?ia?anne?iaaiey aa?aiaiiinoe. A iicaeiea n?iee n?aaee aa?aiaiiuo, eioi?ua i?eieiaee i?aaie/aneoth nieue - aetheiiao aeaeaca, a 19,8% ?acaeeenue i?eciaee AEAeA ?-e noaiaie, i?e eniieueciaaiee iai?aaie/aneiai aeaeaca aiaiey eiaea ianoi a 30,9% neo/aaa. Iaeaunoay /anoioa AEAeA ieacaeanue n?aaee aa?aiaiiuo eiio?ieueiie a?oiiu, eioi?ua ia i?eieiaee i?aia?aoia aeaeaca - 62,2%. Eeth/aaua neiaa: aeaeaciaeaoeoeeoiay aiaiey aa?aiaiiuo, yieaeaieieiaey, i?e/eiu, nuai?ioi/iue oa??eoei, iaiai aeaeaca, ea/aiea ANNOTATION Protsepko O.O. Forecasting and preventive management of Iron Deficiency Anaemia of the pregnant women, living in ecologically adverse conditions.- Manuscript Thesis for a candidate’s degree by speciality 14.01.01 - Obstetrics and Gynaecology.- Vinnitsa State Pirogov Memorial Medical University, Vinnitsa, 1999. The dissertation is devoted to questions of distribution, reasons of growth and risk factors of development IDA among pregnant in present time. Study of iron metabolism during pregnancy was used for developing of new way for IDA preventive management. In dissertation was determine, that IDA among pregnant is a final stage of iron metabolism indemnification. There is a Iron Deficient status (Preanaemia) before developing of anaemia which is determined by serum ferritin decreasing lower than 40-50 mkg/l. For preventing IDA in first trimester using of organic Iron - Ferrous Gluconate (generic name is Totema) was more efficient than nonorganic Iron - Ferrous Sulphate (generic name is Aktiferrin). Treatment by the Ferrous Gluconate after detecting of Iron Deficient status (before developing of haemoglobin concentration changes) was effective for increasing of iron stores and prevent haemoglobin level falls during pregnancy. Key words: Iron Deficiency Anaemia of the pregnant, epidemiology, reasons, serum ferritin, iron metabolism, management. I?aeienaii aei ae?oeo 09.09.99 ?. Caiiae. ? 186. Oi?iao 60o90 1/16 Oi. ae?oe. a?e. 1,0 Ae?oe ionaoiee. Oe?aae 100 i?ei??iee?a. A?iieoey. Ae?oea?iy AAeIO ?i. I.?.Ie?iaiaa, Ie?iaiaa, 56.

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