Профілактика непланованої вагітності при дифузній доброякісній гіперплазії молочних залоз: Автореф. дис… канд. мед. наук / С.А. Ласачко, Ін-т педіат

?INOEOOO IAAe?AO???, AEOOA?NOAA OA A?IAEIEIA??

AEAAeAI?? IAAeE*IEO IAOE OE?A?IE

EANA*EI NA?OEAIA AIAOIE??AIA

OAeE 618:614.2:616-006

I?IO?EAEOEEA IAIEAIIAAII? AAA?OIINO? I?E AeEOOCI?E AeIA?IssE?NI?E
A?IA?IEAC?? IIEI*IEO CAEIC

14.01.01- Aeooa?noai ? a?iaeieia?y

A a o i ? a o a ? a o

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Ee?a – 1999

Aeena?oaoe??th ? ?oeiien.

?iaioo aeeiiaii a Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?
?i.I.Ai?ueeiai IIC Oe?a?ie

Iaoeiaee ea??aiee:

aeieoi? iaaee/ieo iaoe, i?ioani? *AEEA AIEIAeEIE? EE?EEIAE*,

caa?aeoth/ee eaoaae?ith aeooa?noaa, a?iaeieia?? oa ia?eiaoieia??
oaeoeueoaoo i?neyaeeieiiii? ina?oe Aeiiaoeeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo ?i. I.Ai?ueeiai IIC Oe?a?ie

Io?oe?ei? iiiiaioe:

aeieoi? iaaee/ieo iaoe, i?ioani? NIEUeNUeEEE ssE?A II?OE??EIAE*,

caa?aeoaa/ a?aeae?eaiiy a?iaeieia?? ?inoeoooo iaae?ao???, aeooa?noaa oa
a?iaeieia?? AII Oe?a?ie

aeieoi? iaaee/ieo iaoe, i?ioani? OA?OO?IIA AAEA??E ?AAIIAE*,

caa?aeoaa/ a?aeae?eaiiy iooeei iiei/ii? caeice Oe?a?inueeiai
iaoeiai-aeine?aeiiai ?inoeoooo iieieia?? oa ?aae?ieia?? IIC Oe?a?ie

I?ia?aeia onoaiiaa:

Ee?anea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i I.E.Ooi?ea IIC
Oe?a?ie, eaoaae?a aeooa?noaa oa a?iaeieia?? ? 3

Caoeno aeena?oaoe?? a?aeaoaeaoueny “22” ethoiai 2000 ?. i 13 aiae. ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae.26.553.01 ii caoenoo
aeena?oaoe?e ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca
niaoe?aeueiinoyie “Iaae?ao??y”, “Aeooa?noai ? a?iaeieia?y” i?e ?inoeooo?
iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (04050, i.Ee?a-50,
aoe. Iaio?euenueeiai, 8).

C aeena?oaoe??th iiaeia iciaeiieoeny a a?ae?ioaoe? ?inoeoooo iaae?ao???,
aeooa?noaa oa a?iaeieia?? AII Oe?a?ie (04050, i. Ee?a, aoe.
Iaio?euenueeiai,8).

Aaoi?aoa?ao ?ic?neaiee “ 25 ” a?oaeiy 1999 ?ieo.

A/aiee nae?aoa? niaoe?ae?ciaaii?

a/aii? ?aaee E.A.Eaaoi?ia

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Aeia?iye?nia a?ia?ieac?y iiei/ieo caeic (AeAIC)
— iaeia c iaeiioe?ai?oeo caoai?thaaiue na?aae no/anieo ae?iie. Aiii
cono??/a?oueny, ca aeaieie ??cieo aaoi??a, a 20-30% ae?iie, a na?aae
a?iaeieia?/ieo oai?eo — o 50-60% (Neaei?aiei E.I., 1991; Ao?ae?ia E.I.,
1996; Eaaoei A.O., I?ooo I.I., 1993).

?acoeueoaoe aenia?eiaioaeueieo, ee?i?/ieo ? ii?oieia?/ieo aeine?aeaeaiue
inoaii?o ?ie?a aeicaieythoue aaaaeaoe, ui aeia?iye?ni? caoai?thaaiiy
iiei/ii? caeice ? ii/aoeiaith eaieith a i?ioean? ceiye?nii?
o?ainoi?iaoe?? oeaiei oeueiai i?aaio, a aeaye? oi?ie AeAIC — aeciaiei
ia?aae?aeiaei noaiii (Aiaei?iaea I.I., Iaaethe A.Ae., 1991;
Neaei?aiei E.I., 1991; Lee K.C., Chan J.K., Gwi E., 1996). Iaea?eueoa
/anoioa AeAIC niinoa??aa?oueny a ae?iie a?eii 25-49 ?ie?a, oiaoi a oie
ia??iae aeeooy, eiee iaea?eueo aeooaeueii iinoa? ieoaiiy ieaioaaiiy
n?i’?. Iiaaia ii?ioi?iiaai?noue i?i iaoiaee ? caniae eiio?aoeaioe??,
iaaeinoaoi? ?o aeei?enoaiiy ca?eueoo? ?ecee ianoaiiy iaieaiiaaii?
aaa?oiino? ? i?ecaiaeeoue aei ?inoo /enea ooo/ieo aai?o?a, ui, a naith
/a?ao, aaaea aei ?inoo a?iaeieia?/ii? caoai?thaaiino? ? iaie?aeiino?
(Aiaaoe?ueiaa ?.A., ??e?ia O.E., 1997; Aiae ?.A., 1997;
Nieuenueeee ss.I., Na?e?nyi A.A., Oaoa?/oe O.O., 1996).

Aaa?oi?noue o a?oe? i?ney 35 ?ie?a, iniaeeai ia?a?aaia, aaeeea /enei
aai?o?a a aiaiiac? iaeaaeaoue aei /eiiee?a ?eceeo aeieeiaiiy ?aeo
iiei/ii? caeice (?aiaii?e E.?., 1990; Oa?oo?iia A.?., 1998). sseui
aeia?iye?nia caoai?thaaiiy iiei/ii? caeice aaea ?nio?, ?ecee
i?aeaeuo?oueny a aaaaoi ?ac?a. E??i oiai, no?ao ianoaiiy iaaaaeaii?
aaa?oiino? i?ecaiaeeoue aei aeieeiaiiy aeeneiioi?oo a naenoaeueiiio
aeeoo? ae?iee, naenoaeuei?e iaaaeiaieaiino? ? ia?aiai-ineo?/iiio
iai?oaeaiith, ? aeeeeea? iia??oaiiy ia?aa?ao AeAIC. Ii?iae?caoe?y
naenoaeueii? ooieoe?? ? aaaeeeaith eaieith a eiiieaeni?e iaaee/i?e
?aaa?e?oaoe?? oai?eo ia AeAIC (Neaei?aiei E.I., 1991). Ana oea
na?ae/eoue i?i oa, ui oe? ae?iee iio?aaothoue iaae?eieo ? aacia/ieo
iaoiae?a ? cania?a eiio?aoeaioe??. Oaeei /eiii, i?iaeaia i?io?eaeoeee
iaieaiiaaii? aaa?oiino? o ae?iie c AeAIC ? aeooaeueiith.

Iacaaaeath/e ia oea, a e?oa?aoo?? ?niothoue eeoa ie?ai? ioae?eaoe??
uiaei aeei?enoaiiy oeo /e ?ioeo cania?a eiio?aoeaioe?? o oai?eo ia
AeAIC. A?aenooi? aeai? i?i aoaeoeai?noue ? i?eeiyoi?noue ??cieo iaoiae?a
eiio?aoeaioe?? a oe?e a?oi? ae?iie, iaaeinoaoiuei aea/aii aieea ??cieo
aeae?a eiio?aoeaioea?a ia noai iiei/ieo caeic, ia?aa?a caoai?thaaiiy ?
ai?iiiaeueiee aaeain oai?eo ia AeAIC, ia ?nio? caaaeueiii?eeiyoeo aeey
iieieia?a, o??o?a?a ? aeooa??a-a?iaeieia?a noai ? aeai?eoi?a
?iaeea?aeoaeueiiai aeiai?o iaoiae?a eiio?aoeaioe?? aeey oeeo ae?iie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie.
Aeena?oaoe?th aeeiiaii ca?aeii c ieaiii IAe? Aeiiaoeueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ?i. I.Ai?ueeiai IIC Oe?a?ie, ?iaioa ?
o?aaiaioii eiiieaenii? oaie “?ic?iaea iiaeo i?aeoiae?a aei
i?io?eaeoeee oa e?eoaaiiy iaie?aeiiai oethao” IIC Oe?a?ie, ? aea?ae.
?a?no?aoe?? 0197V002125, oeo? oaie IE 950605. Aaoi? ? aeeiiaaoeai oaie.

Iaoa aeine?aeaeaiiy. Caa?aaeaiiy ?ai?iaeoeoeaiiai caei?ia’y, cieaeaiiy
e?eueeino? iaaee/ieo aai?o?a oa a?iaeieia?/ii? caoai?thaaiino? na?aae
ae?iie c AeAIC caaaeyee ?ic?iaoe? ? canoinoaaiith iaoeiai
iaa?oioiaaieo e?eoa???a ?iaeea?aeoaeueiiai aeiai?o iaoiae?a
i?io?eaeoeee iaieaiiaaii? aaa?oiino? aeey oai?eo ia AeAIC.

Iniiai? caaea/? aeine?aeaeaiiy:

Aea/eoe iniaeeaino? noaio ?ai?iaeoeoeaiiai caei?ia’y oa aiaiiaco oai?eo
ia AeAIC, aeei?enoaiiy ??cieo iaoiae?a eiio?aoeaioe?? a oe?e a?oi?
ae?iie.

Aea/eoe noai a?iio?ca?ii-y?/ieeiai? nenoaie caei?iaeo ae?iie ? oai?eo ia
AeAIC a aeeiai?oe? iaino?oaeueiiai oeeeeo, a oaeiae a caeaaeiino? a?ae
nooiaiy aaaeeino? caoai?thaaiiy.

Aeine?aeeoe aieea ??cieo aeae?a i?aeueieo eiio?aoeaioea?a (IE) ia
iieacieee ai?iiiaeueiiai noaoono oai?eo aeeoocieie oi?iaie AeAIC.

Aecia/eoe aieea ??cieo iaoiae?a eiio?aoeaioe?? ia noai iiei/ieo caeic
ae?iie c aeeoocieie oi?iaie AeAIC ? ia?aa?a caoai?thaaiiy.

Aea/eoe aoaeoeai?noue ? i?eeiyoi?noue ??cieo iaoiae?a eiio?aoeaioe??
aeey oai?eo ia AeAIC.

?ic?iaeoe ? iaoeiai iaa?oiooaaoe aeai?eoi ?iaeea?aeoaeueiiai
aeeoa?aioe?eiaaiiai aeiai?o iaoiae?a i?io?eaeoeee iaieaiiaaii?
aaa?oiino? aeey oai?eo aeeoocieie oi?iaie AeAIC o caeaaeiino? a?ae a?eo,
noaio iiei/ieo caeic, iieaciee?a ai?iiiaeueiiai noaoono oa noiooi?o
caoai?thaaiue.

Iaoeiaa iiaecia ?iaioe. Aia?oa aea/aii iniaeeaino? aeei?enoaiiy ??cieo
iaoiae?a eiio?aoeaioe?? ae?ieaie c AeAIC.

Aia?oa aecia/aii noai a?iio?ca?ii-y?/ieeiai? nenoaie o oai?eo ia AeAIC a
caeaaeiino? a?ae nooiaiy aaaeeino? caoai?thaaiiy c aeei?enoaiiyi oeaee
ee?i?/ii? ioe?iee noaio iiei/ieo caeic.

Aia?oa aea/aii aieea ??cieo aeae?a IE ia ai?iiiaeueiee aaeain oai?eo
aeeoocieie oi?iaie AeAIC. Aeiaaaeaii, ui an? aeaee IE i?e i?aaeeueiiio
aeiai?? c o?aooaaiiyi ?iaeea?aeoaeueieo iniaeeainoae ai?iiiaeueiiai
noaoono iathoue iiceoeaiee aieea ia ai?iiiaeueio nenoaio oeeo ae?iie. A
iaea?eueo?e i??? oeae aoaeo i?eoaiaiiee /enoi i?iaanoeiiaei
eiio?aoeaioeaai.

Aia?oa aea/aii a ii??aiyeueiiio ieai? aieea ??cieo iaoiae?a
eiio?aoeaioe?? ia noai iiei/ieo caeic ae?iie c aeeoocieie oi?iaie AeAIC
oa ia?aa?a caoai?thaaiiy. Aeiaaaeaii, ui canoinoaaiiy ai?iiiaeueii?
eiio?aoeaioe?? ca oiia ?iaeea?aeoaeueiiai aeiai?o i?ecaiaeeoue aei
iie?ioaiiy ia?aa?ao AeAIC, a o?eaaea aeei?enoaiiy o?aaeeoe?eieo iaoiae?a
eiio?aoeaioe??, iaaiaee, ni?ey? iia??oaiith noaio iiei/ieo caeic i?e
oeueiio caoai?thaaii?.

?ic?iaeaii ? ai?iaaaeaeaii a i?aeoeeo aeai?eoi ?iaeea?aeoaeueiiai
aeeoa?aioe?eiaaiiai aeiai?o iaoiae?a i?io?eaeoeee iaieaiiaaii?
aaa?oiino? aeey oai?eo ia aeeoocio AeAIC a caeaaeiino? a?ae a?eo, noaio
iiei/ieo caeic, iieaciee?a ai?iiiaeueiiai noaoono ? iayaiino? noiooi?o
caoai?thaaiue.

I?aeoe/ia cia/aiiy ?iaioe. Aeey i?aeoe/ii? ?iaioe e?ea??a
aeooa??a-a?iaeieia?a, o??o?a?a, iieieia?a, ye? caeiathoueny e?eoaaiiyi ?
aeeniaina?iei iaaeyaeii ca ae?ieaie c AeAIC, ?aeiiaiaeiaaii aeai?eoi
?iaeea?aeoaeueiiai aeeoa?aioe?eiaaiiai aeiai?o iaoiae?a i?io?eaeoeee
iaieaiiaaii? aaa?oiino? aeey oai?eo ia aeeoocio AeAIC c o?aooaaiiyi a?eo
ae?iee, noaio iiei/ieo caeic, iieaciee?a ai?iiiaeueiiai noaoono ?
iayaiino? noiooi?o caoai?thaaiue, yeee aeicaiey? i?aeoe/iei e?ea?yi
oaeaeei ? i?aaeeueii ?aeiiaiaeoaaoe iaoiae eiio?aoeaioe?? c
iaeneiaeueiith ei?enoth aeey caei?ia’y iaoe??ioie. I?iaaaeaii
iaoiaaiaoe/ia iaa?oiooaaiiy iiceoeaiiai aieeao IE ia ai?iiiaeueiee
aaeain, noai iiei/ieo caeic ? aeeiai?eo caoai?thaaiiy o ae?iie c
aeeoocieie oi?iaie AeAIC.

Aeei?enoaiiy aeaiiai aeai?eoio aeicaiey? cieceoe e?euee?noue ooo/ieo
aai?o?a a oe?e a?oi? ae?iie c 19,8 % aei 4,5 %, a a?iaeieia?/io
caoai?thaai?noue c 72,0 % aei 35,9 %.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy. ?acoeueoaoe aeine?aeaeaiiy ?
?ic?iaeaiee aeai?eoi ?iaeea?aeoaeueiiai aeeoa?aioe?eiaaiiai aeiai?o
iaoiae?a i?io?eaeoeee iaieaiiaaii? aaa?oiino? aeey ae?iie c aeeoocieie
oi?iaie AeAIC ai?iaaaeaeai? a ?iaioo ae?ii/eo eiinoeueoaoe?e i.
Aeiiaoeueea, a?aeae?eaiiy ieaioaaiiy n?i’? Aeiiaoeueeiai aea?aeaaiiai
?aa?iiaeueiiai oeaio?o ioi?iie iaoa?einoaa oa aeeoeinoaa (AeAe?OeIIAe),
iie?ee?i?/iiai a?aeae?eaiiy Aeiiaoeueeiai iaeaniiai i?ioeiooeeiiiai
oeaio?o, a ?iaioo ae?ii/i? eiinoeueoaoe?? Euea?anueei? iaeanii?
ee?i?/ii? e?ea?i?.

Oai?aoe/i? iieiaeaiiy ? i?aeoe/i? ?aeiiaiaeaoe?? aeena?oaoe?eii? ?iaioe
aeei?enoiaothoueny ia eaeoe?yo ? i?aeoe/ieo caiyooyo aeey
e?ea??a-?ioa?i?a, ia eo?nao i?aeaeuaiiy eaae?o?eaoe??, noaaeoaaiiy oa
?ioi?iaoe?? aeey e?ea??a Aeiiaoeueei? iaeano? ia eaoaae?? aeooa?noaa,
a?iaeieia?? oa ia?eiaoieia?? oaeoeueoaoo i?neyaeeieiiii? ina?oe
Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.Ai?ueeiai IIC
Oe?a?ie.

Iniaenoee aianie caeiaoaa/a. Aeena?oaioii i?iaaaeaii ee?i?/ia
ianoaaeaiiy 162 ae?iie ?ai?iaeoeoeaiiai a?eo, oai?eo ia aeeoocio
AeAIC, ? 60 ae?iie eiio?ieueii? a?oie. Aea/aii noai
a?iio?ca?ii-y?/ieeiai? nenoaie ianoaaeaieo ae?iie, i?iaaaeaii
noaoenoe/io ia?iaeo aeaieo. Aeine?aeaeaii aieea ??cieo aeae?a
eiio?aoeaioe?? ia aeaye? iieacieee ai?iiiaeueii? nenoaie, noai
iiei/ieo caeic ? ia?aa?a caoai?thaaiiy o oai?eo ia AeAIC.
?ic?iaeaii ? iaoeiai iaa?oioiaaii aeai?eoi aeeoa?aioe?eiaaiiai
aeiai?o iaoiae?a i?io?eaeoeee iaieaiiaaii? aaa?oiino? aeey
oai?eo ia aeeoocio AeAIC a

caeaaeiino? a?ae a?eo, noaio iiei/ieo caeic, iieaciee?a ai?iiiaeueiiai
noaoono ? noiooi?o caoai?thaaiue. I?iaaaeaii noaoenoe/io ia?iaeo
io?eiaieo ?acoeueoao?a oa ?o aiae?c.

Ai?iaaoe?y ?iaioe. Iaoa??aee aeena?oaoe?? aeiiia?aeaeenue ia
can?aeaii? eaoaae?e aeooa?noaa, a?iaeieia?? oa ia?eiaoieia?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo (i. Aeiiaoeuee, 1998); ia can?aeaii? A/aii? ?aaee Oe?IAe?
iaaee/ieo i?iaeai n?i’? (i. Aeiiaoeuee, 1999); aoee i?aaenoaaeai? ia
i?aeiaeani?e iaoeiai-i?aeoe/i?e eiioa?aioe?? aeooa??a-a?iaeieia?a,
i?enay/ai?e 30-??/iiio tha?eath eaoaae?e aeooa?noaa ? a?iaeieia??
oaeoeueoaoo oaeineiiaeaiiy e?ea??a (i. Aeiiaoeuee, 1995); O c’?cae?
aeooa??a-a?iaeieia?a Oe?a?ie (i. Iaeana, 1996).

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 8 ?ia?o, o oiio
/ene? 4 noaoo? a oeaio?aeueieo iaaee/ieo aeo?iaeao, 2 — o ca??ieeao
iaoeiaeo i?aoeue, 2 — a oacao.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?th aeeeaaeaii ia 174
noi??ieao iaoeiiieniiai oaenoo. Aiia neeaaea?oueny c? anooio, iaeyaeo
e?oa?aoo?e, /ioe?ueio ?icae?e?a c aeeeaaeaiiyi ?acoeueoao?a aeanieo
aeine?aeaeaiue, aiae?co oa ocaaaeueiaiiy io?eiaieo ?acoeueoao?a,
aeniiae?a, i?aeoe/ieo ?aeiiaiaeaoe?e, nieneo aeei?enoaieo aeaea?ae.
Oaenoiao /anoeio aeeeaaeaii ia 108 noi??ieao. Nienie aeei?enoaieo
aeaea?ae i?noeoue 233 ?iaioe, c ieo 138 — a?o/eciyieo ? 95 — ?iicaiieo
aaoi??a, oa caeia? 26 noi??iie. ?iaioo i?i?ethno?iaaii 29 oaaeeoeyie
? 13 ?enoieaie, ye? caeiathoue 40 noi??iie.

INIIAIEE CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeey aeinyaiaiiy iinoaaeaii?
iaoe iaie aoei ianoaaeaii 60 ae?iie ?ai?iaeoeoeaiiai a?eo, a yeeo ia
aoei aeyaeaii caoai?thaaiue iiei/ieo caeic (?, aai eiio?ieueia,
a?oia), a oaeiae 162 ae?iee ?ai?iaeoeoeaiiai a?eo, oai?eo ia AeAIC (118
ae?iie iniiaii? (??) a?oie oa 44 ae?iee a?oie ii??aiyiiy (???)). AE?iee
iniiaii? oa eiio?ieueii? a?oi c iaoith caiia?aaiiy iaaaaeaii?
aaa?oiino? aeei?enoiaoaaee IE. 118 ae?iie iniiaii? a?oie aoee
iiae?eai? ia o?e i?aea?oie: i?aea?oia II.A — 38 iaoe??ioie, ye?
i?eeiaee iiiioaci? eiia?iiaai? ano?iaai-aanoaaaii? ai?iiiaeuei?
eiio?aoeaioeae oeio ia?aaeii, ei-oaiaiie; i?aea?oia II.A — 38 ae?iie, ui
aeei?enoiaoaaee o?eoaci? eiia?iiaai? ano?iaai-aanoaaaii? ai?iiiaeuei?
eiio?aoeaioeae oeio o?e-?aaie, o?eea?ea?, o?ec?noii, oa II.A i?aea?oia—
42 iaoe??ioee, ye? i?eeiaee i?i?-i?e? — aanoaaaii? eiio?aoeaioeae oeio
aenethoii, ia?ao, eiio?io?i. AE?iee ??? a?oie ia aeei?enoiaoaaee
ai?iiiaeueio eiio?aoeaioe?th. C iaoith caiia?aaiiy iaaaaeaii? aaa?oiino?
aiie aaeeaaee oae caai? “o?aaeeoe?ei?” iaoiaee: aa?’??iee, eaeaiaea?iee,
coitus interruptus oa ?o eiia?iaoe??. Eiio?ieueia a?oia oaeiae
aoea iiae?eaia ia o?e i?aea?oie: I.A — 20 ae?iie, ui aeei?enoiaoaaee
iiiioaci? eiia?iiaai? i?aeuei? eiio?aoeaioeae (EIE); i?aea?oia I.A — 20
ae?iie, ye? i?eeiaee o?eoaci? EIE, i?aea?oia I.A — 20 ae?iie, ui
i?eeiaee i?i?-i?e?.

Ianoaaeaiiy ae?iie i?iaiaeeeinue ia aac? a?aeae?eaiiy ieaioaaiiy n?i’?
AeAe?OeIIAe.

Na?aae on?o ae?iie aoei i?iaaaeaia aieaooaaiiy, ca aeiiiiiaith yeiai
iaie aeaoaeueii aea/aii caaaeueiee, aeooa?nueeee oa a?iaeieia?/iee
aiaiiac, oiiae i?aoe?, aeeooy, ??aaiue ina?/aiino? uiaei cania?a
eiio?aoeaioe??, a?aeiioaiiy aei ??cieo iaoiae?a eiio?aoeaioe??. I?e
cae?aii? aiaiiaco oa i?iaaaeaii? eiai aiae?co iniaeeaa oaaaa
i?eae?eyeanue ianooiiei aeaiei: n?iaeiee aiaiiac (n?iaeiee noai,
iayai?noue o ?iaee/?a caoai?thaaiue iiei/ieo caeic, a oaeiae
iieieia?/ieo oa aiaeie?eiieo caoai?thaaiue); ia?aianai? oa noiooi?
caoai?thaaiiy iiei/ieo caeic, ueoiaeaeii? caeice, ia/?iee oa ?io?;
a?iaeieia?/iee aiaiiac (noaiiaeaiiy ? oa?aeoa? iaino?oaeueii? ooieoe??,
ia?aianai? oa noiooi? a?iaeieia?/i? caoai?thaaiiy, iia?aoeai? ao?o/aiiy
ia i?aaiao iaeiai oaco); ?ai?iaeoeoeaiee aiaiiac (e?euee?noue
aaa?oiinoae, na?aae ieo — iieia?a oa ooo/ieo aai naiia?eueieo aai?o?a,
oneeaaeiaiiy; a?e i?e ia?o?e oa inoaii?e aaa?oiinoyo; iayai?noue
aaa?oiinoae, cie?aia ia?a?aaieo, i?ney 35 ?ie?a; o?eaae?noue oa
iniaeeaino? eaeoaoe??; iaoiaee eiio?aoeaioe??, ui canoiniaoaaeenue).

Ia’?eoeaia aeine?aeaeaiiy aeeth/aei aei??thaaiiy aaae, ?inoo, caaaeueia
ianoaaeaiiy, iaeyae oa iaeueiaoe?th iiei/ieo caeic oa ?aa?iia?ieo
e?ioaoe/ieo aoce?a. Aeey aeyaeaiiy aeno?aaai?oaeueii? iaoieia?? an?
ae?iee aoee i?ieiinoeueoiaai? oa?aiaaoii, aiaeie?eiieiaii,
iaa?iiaoieiaii, ieoe?noii, o??o?aii.

An?i ae?ieai i?iaiaeeee ?aoaeueia a?iaeieia?/ia ianoaaeaiiy.
Oeueo?acaoeiaa aeine?aeaeaiiy i?iaiaeeee ia aia?ao? “Toshiba” a ia?oo
oaco iaino?oaeueiiai oeeeeo aeao/eeaie c /anoioith 3,5 oa 5 IAoe.
Aecia/aee oaeiae caaaeueiiee?i?/i? aiae?ce e?ia?, na/?, aiae?c aai
aaeoa??ieia?/ia aeine?aeaeaiiy aaa?iaeueieo aeae?eaiue. I?e iio?aa?
aeeiioaaee ?aioaaiieia?/ia aeine?aeaeaiiy /a?aio (oo?aoeueeiai n?aeea) c
iaoith aeeeth/aiiy i?aai?/ieo caoai?thaaiue a?iio?co.

Iaie aoee aeei?enoai? ianooii? iaoiaee ianoaaeaiiy iiei/ieo caeic:
ee?i?/iee, oeeoieia?/iee, oeueo?acaoeiaee, iaiia?ao?y. I?ney iaeyaeo oa
iaeueiaoe?? ee?i?/iee noai iiei/ieo caeic ioe?ithaaee ca oeaeith
E.I.Neaei?aiei, 1991 ?.. ?aioaaiieia?/ia aeine?aeaeaiiy i?iaiaeeee ia
niaoe?aeueiiio iaiia?ao? “Aeaeo?ii?ea” c aeei?enoaiiyi iineethth/eo
ae?ai?a c iiaeeiaiith aeicith ia iaeei ci?iie 0,1 iCa. Aeine?aeaeaiiy
aeeiioaaee a ia?oo oaco iaino?oaeueiiai oeeeeo a aeaio noaiaea?oieo
i?iaeoe?yo (i?yi?e oa aieia?e). Aeei?enoiaoaaee oaeiae oeeoieia?/ia
aeine?aeaeaiiy ioieoaoo, aeiaooiai ca aeiiiiiaith oiiei? aieee, oa
aeae?eaiue ?c nine?a. Oeueo?acaoeiaa neaioaaiiy i?iaiaeeee ia aia?ao?
“Sonoscop — 20” o??ie Kranzb(hler (I?ia//eia) e?i?eiei aeao/eeii c
/anoioith 7,5 MAoe c aeei?enoaiiyi n??i? oeaee ca?aeii c
caaaeueiii?eeiyoith iaoiaeeeith a ?aaeueiiio ianooaa? /ano c 7 ii 14
aeaiue iaino?oaeueiiai oeeeeo.

Ioe?ieo ai?iiiaeueiiai noaoono i?iaiaeeee oeyoii aecia/aiiy a ne?iaaooe?
e?ia? eiioeaio?aoe?e ai?iii?a a?iio?co (oie?eoeinoeioethth/iai (ONA),
ethoa?i?coth/iai (EA), i?ieaeoeio (I?E)) oa noa?i?aeieo ai?iii?a
(ano?aae?ieo (A2), i?iaanoa?iio (I)) ia 6-8 oa 20-22 aei?
iaino?oaeueiiai oeeeeo. Aeine?aeaeaiiy i?iaiaeeee ?ioiioa?iaioiei
iaoiaeii c aeei?enoaiiyi noaiaea?oieo iaai??a o??ie UBI MAGIWEL oa
Clone Systems (NOA) noai?i ca ?ino?oeoe?yie, ui aoee iaaeai? o??iith
aeey eiaeiiai ai?iiio ie?aii.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Neeaae ae?iie ianoaaeaieo
a?oi ca a?eii oa nioe?aeueiei noaiii aeinoia??ii ia a?ae??ciyany,
aea o oai?eo ia AeAIC i?aoey a 1,4 ?ace /ano?oa aoea
iia’ycaia c i?ioan?eieie oe?aeeeainoyie, ? a 2,2 ?ace — c
ia?aiai-ineo?/iei iai?oaeaiiyi.

Ee?i?ei-noaoenoe/iee aiae?c ?iaeea?aeoaeueieo ea?o iieacaa, ui a 93,7%
oai?eo ia AeAIC niinoa??aathoueny iani?eyoeea? iniaeeaino?
a?iaeieia?/iiai, n?iaeiiai oa ?ai?iaeoeoeaiiai aiaiiaco.

O 28,4% oai?eo ia AeAIC aeyaeany aeinoia??ii i?ci?oee a?e iaia?oa (14(15
?ie?a), i?ae na?aae ae?iie eiio?ieueii? a?oie (8,3%). A a?oe? 11-13
?ie?a noaiiaeaiiy iaia?oa a?aecia/aii a 90,0% ae?iie eiio?ieueii? a?oie,
a a oai?eo ia AeAIC oeae iieaciee aeinoia??ii ieae/ee: 60,5%.
Noaiiaeaiiy iaino?oaeueiiai oeeeeo a oai?eo ia AeAIC aoei aeinoia??ii
o?eaae?oei, i?ae a eiio?ieuei?e a?oi?. Na?aae 63,3% ae?iie eiio?ieueii?
a?oie oa 32,1% oai?eo ia AeAIC iaino?oaeueiee oeeee anoaiiaeany
iae?aco, a?aeiia?aeii na?aae 30,0% oa 21,6% — i?ioyaii 6 i?nyoe?a,
o 5,0% oa 25,9% — i?ioyaii 1 ?ieo, a 1,7% oa a 17,1% — i?ioyaii 2-o
?ie?a. O?eaae?noue iaino?oaeueiiai oeeeeo aei 26 aei?a
a?aecia/aii o 10,0 % ae?iie eiio?ieueii? a?oie oa 29,6% oai?eo ia
AeAIC; a?ae 27 aei 29 aei?a — o 80,0% oa 38,3%; a?ae 30 aei 35 aei?a —
o 10,0% oa 32,1% a?aeiia?aeii.

Ioaea, aeey oai?eo ia AeAIC oa?aeoa?ieie aeyaeeenue a?eueo i?ci?e a?e
iaia?oa oa noaiiaeaiiy iaino?oaeueiiai oeeeeo i?ioyaii a?eueo o?eaaeiai
/ano, i?ae o caei?iaeo ae?iie; aei?i/aiee (aei 26 aei?a) aai a?eueo
o?eaaeee (iiiaae 30 aei?a) iaino?oaeueiee oeeee. I?aeoaa?aeaeaiiy iaoei
aeaiei ie ciaeoee a na?oia?e e?oa?aoo?? (Neaei?aiei E.I., 1991;
Hilakivi-Clarke L., Clarke R., Lippman M.E., 1994). Ca?aeii c oeeie
aeaieie, aei?i/aiee iaino?oaeueiee oeeee a?aeiia?aea? a?ia?ano?iaaiai??,
oeeee o?eaae?noth a?eueo i?ae 30 aei?a — a?aeo i?iaanoa?iio a ae?oa?e
oac? iaino?oaeueiiai oeeeeo.

Aeey ae?iie c AeAIC oa?aeoa?ieie aeyaeeenue oae? iani?eyoeea?
iniaeeaino? ?ai?iaeoeoeaiiai aiaiiaco: a?aenooi?noue iieia?a aai o?eueee
?aeei? iieiae (72,2% aeiaaee?a, a eiio?ie? 50,0%); a 38,2% — e?euee?noue
ooo/ieo aai naiia?eueieo aai?o?a a?eueoa o?ueio (a eiio?ie? 6,7%); a
46,9% oai?eo ia AeAIC iaee i?noea ia?a?aai? aaa?oiino? aei ia?oeo
iieia?a (a eiio?ie? a 8,6%), oa a 19,1% — o a?oe? noa?oa 35 ?ie?a (a
eiio?ie? a 4,3%).

Ii?ooaiiy eaeoaoe?eii? ooieoe??, iayai?noue noiooi?o a?iaeieia?/ieo
caoai?thaaiue, iniaeeai caiaeueieo oa a?ia?ieanoe/ieo i?ioean?a,
iani?eyoeea? iniaeeaino? n?iaeiiai e naenoaeueiiai aiaiiaco aaaaeathoue
oaeoi?aie ?eceeo aeieeiaiiy aeia?iye?nieo oa ceiye?nieo caoai?thaaiue
iiei/ii? caeice (Oa?oo?iia A.?., 1998; Ao?ae?ia E.I., 1996; Zhang J. et.
al., 1995). A iaoiio aeine?aeaeaii? ii?ooaiiy eaeoaoe?eii? ooieoe??
a?aecia/aeeny a 61,1% oai?eo ia AeAIC (a eiio?ie? a 19,7%), o?eaae?
caiaeuei? caoai?thaaiiy iaoee ? i?eaeaoe?a a 50,6% (a eiio?ie? a 21,7%);
a 41,4% — aaeoa??aeuei? aaa?iice ? eieuei?oe (a eiio?ieuei?e a?oi? a
16,7%); a 27,8% — ii?ooaiiy iaino?oaeueiiai oeeeeo (a eiio?ie? na?aae
13,3%); iooeeii? ? a?ia?ieanoe/i? i?ioeane ae?ii/eo noaoaaeo i?aai?a a
24,7% (a eiio?ie? a 6,7%); o?eaae? aai aino?? no?ania? neooaoe?? a 63,6%
(a eiio?ie? a 37,4%); iani?eyoeea? iniaeeaino? n?iaeiiai ? naenoaeueiiai
aiaiiaco a 45,5% (a eiio?ie? a 25,1%).

Caoai?thaaiiy oeoieiai-eeoeiaiai o?aeoo ? ia/?iee a oai?eo ia AeAIC
cono??/aeenue aeinoia??ii /ano?oa (40,7%), i?ae o caei?iaeo ae?iie
(10,0%), ueoiaeaeii? caeice a?aeiia?aeii a 16,7% oa 1,7%, oeaio?aeueii?
? aaaaoaoeaii? ia?aiai? nenoaie a 29,7% oa 10,1%.

Aiae?c n?iaeiiai aiaiiaco o ianoaaeaieo iaie ae?iie aeaco? ia ?ieue
niaaeeiai? noeeueiino? a ?icaeoeo AeAIC. A ?iaee/?a oai?eo ia AeAIC
/ano?oa cono??/aeeny iieieia?/i? caoai?thaaiiy (33,3%, a eiio?ie? 6,7%),
iniaeeai ae?ii/eo noaoaaeo i?aai?a ? iiei/ieo caeic (11,7%, a eiio?ie?
3,4%), aeia?iye?ni? iiaiooai?aiiy ae?ii/eo noaoaaeo i?aai?a oa iiei/ieo
caeic (35,8%, na?aae ?iaee/?a caei?iaeo ae?iie a 6,7%), AeAIC (12,3%, a
eiio?ie? a 1,7%) oa iae?iaiaeie?eii? e iai?ii? caoai?thaaiiy (35,0% oa
6,7%).

Aiae?c aeaieo aieaooaaiiy noiniaii iaoiae?a eiio?aoeaioe??, ui
aeei?enoiaothoueny, iieacaa, ui oai?? ia AeAIC iaaeinoaoiuei ciaeii? c
iaoiaeaie oa caniaaie eiio?aoeaioe??, ai?iiiaeueio eiio?aoeaioe?th
aeei?enoiaothoue o?eueee 6,8 % ae?iie oe??? a?oie (a eiio?ie? 20,0%).
A?eueo?noue (62,3 % ae?iie) ei?enoothoueny iaeiaoaeoeaieie
o?aaeeoe?eieie iaoiaeaie eiio?aoeaioe?? (a eiio?ie? 48,4%), a 16,0 % ia
aeei?enoiaothoue cian?i i?yeeo iaoiae?a (a eiio?ie? 3,3%). O ca’yceo c
oeei ni?aa?aeiioaiiy ia?a?aaieo aaa?oiinoae oa iieia?a a oe?e a?oi?
ae?iie aeoaea aeniea oa neeaaea? 2,1?1, a eiio?ieuei?e a?oi? 0,8?1. Ana
oea na?ae/eoue i?i oa, ui ae?iee ?ai?iaeoeoeaiiai a?eo, oai?? ia AeAIC,
iaeaaeaoue aei a?oie ?eceeo c iaieaiiaaii? aaa?oiino? e iio?aaothoue
aenieiaoaeoeaieo no/anieo iaoiae?a eiio?aoeaioe??.

Iaie aoa aea/aiee noai ooieoe?? a?iio?ca?ii-y?/ieeiai? nenoaie o 162
ae?iie ?ai?iaeoeoeaiiai a?eo, oai?eo ia AeAIC. Ne?ae ie?aii cacia/eoe,
ui ia aoei ciaeaeaii nooo?aeo a?aei?iiinoae a noai? ai?iiiaeueii?
nenoaie o ae?iie c ??cieie ee?i?/ieie oi?iaie caoai?thaaiiy. Iaoa
?iaioa, ca?aeii c iaoith, ia? oaeo iniaeea?noue, ui aei ia? oa?eoee eeoa
o? ae?iee c AeAIC, ye? iio?aaothoue eiio?aoeaioe??. Oiaoi aaeeea
e?euee?noue ?ioeo oai?eo ia AeAIC caeeoeeanue iica iaaeaie oeueiai
aeine?aeaeaiiy. Oea ianaiia?aae o? ae?iee, a yeeo caoai?thaaiiy aeieeei
ia oii? oaeeo aiaeie?eiieo ii?ooaiue, ui ? i?e/eiith iaie?aeiino?,
cae/iiai iaaeiiooaaiiy aaa?oiino?, oai??, ye? ia?aianee iia?aoeai?
ao?o/aiiy ia noaoaaeo i?aaiao, i?ney yeeo ianoaiiy aaa?oiino?
iaiiaeeeaa. Ia? cia/aiiy oaeiae oie oaeo, ui aei aeine?aeaeaiiy ia
oa?eoee oai?? ia AeAIC iica?ai?iaeoeoeaiiai a?eo, a oaeiae o? ae?iee,
ui ia iathoue noaoaaeo noinoie?a i?ioyaii o?eaaeiai /ano. Ca?aeii c
aeaieie ??cieo aaoi??a, oae? iaoe??ioee na?aae oai?eo ia AeAIC
noaiiaeyoue a?ey 25-40 % (Aeai?aeia N.I., 1991; Neaei?aiei E.I., 1991).

Iaie ciaeaeai? nooo?a? a?aei?iiino? a noai? a?iio?ca?ii-y?/ieeiai?
nenoaie oai?eo ia AeAIC oa ae?iie eiio?ieueii? a?oie. Na?aaeiy
eiioeaio?aoe?y ONA a oie?eoe?iiao oaco iaino?oaeueiiai oeeeeo aei??aith?
10,52±0,30 iea/e o oai?eo ia AeAIC ? 6,22±0,18 iea/e a eiio?ieuei?e
a?oi?, oiaoi niinoa??aa?oueny ia?aaeuaiiy a 1,7 ?ace (p<0,05). A ethoa?iiao oaco oeeeeo oe? iieacieee aei??aiththoue a?aeiia?aeii 5,71±0,20 iea/e oa 3,48±0,16 iea/e (ia? i?noea ia?aaeuaiiy a 1,6 ?ace, p<0,05). Na?aaeiy eiioeaio?aoe?y EA a ia?oo oaco oeeeeo aei??aith? 9,67±0,32 iea/e a iniiai?e a?oi? oa 4,14±0,18 iea/e a eiio?ieuei?e, a ae?oao oaco oeeeeo oe? iieacieee noaiiaeyoue a?aeiia?aeii 5,30±0,23 iea/e oa 3,66±0,17 iea/e. Oaeei /eiii, niinoa??aa?oueny ia?aaeuaiiy iieaciee?a eiio?ieueii? a?oie a 2,3 ?ace a oie?eoe?iiao oaco iaino?oaeueiiai oeeeeo oa a 1,4 ?ace a ethoa?iiao (p<0,05). I?e oeueiio ni?aa?aeiioaiiy ONA/EA caeeoa?oueny a iaaeao ii?ie (1,1-1,5) (O?aayiei O.Ae., Nieuenueeee ss.I., 1989) e ?noioii ia a?ae??ciy?oueny a?ae iieacieea eiio?ieueii? a?oie a ae?oao oaco iaino?oaeueiiai oeeeeo, a a ia?oo oaco iaino?oaeueiiai oeeeeo ci?ith?oueny ia ei?enoue EA oa aei??aith? 1,2 o oai?eo ia AeAIC ? 1,5 a eiio?ieuei?e a?oi? (p<0,05). ??aaiue i?ieaeoeio a oai?eo ia AeAIC noaiiaeoue 18,39±0,62 ia/ie oa ia?aaeuo? iieaciee eiio?ieueii? a?oie (6,94±0,26 ia/ie) a 2,6 ?ace. ??aaiue A2 a oai?eo ia AeAIC noaiiaeoue 0,93±0,06 iiieue/e ? ia?aaeuo? iieaciee eiio?ieueii? a?oie (0,43±0,02 iiieue/e) a 2,1 ?ace a oie?eoe?iiao oaco iaino?oaeueiiai oeeeeo. A ethoa?iiao oaco oe? iieacieee aei??aiththoue a?aeiia?aeii 1,05±0,04 iiieue/e oa 0,59±0,01 iiieue/e, oiaoi niinoa??aa?oueny ia?aaeuaiiy o 1,8 ?ace. ??aaiue I a ia?oo oaco oeeeeo aeuee a eiio?ieuei?e a?oi? a 1,4 ?ace ? noaiiaeoue 5,41±0,21 iiieue/e, a na?aae oai?eo ia AeAIC — 3,79±0,37 iiieue/e (p<0,05). A ae?oao oaco oeeeeo oe? iieacieee aei??aiththoue a?aeiia?aeii 27,91±0,73 iiieue/e oa 13,60±1,28 iiieue/e, oiaoi ia? i?noea cieaeaiiy ai?noo I a oai?eo ia AeAIC a 2,1 ?ace a ii??aiyii? c eiio?ieueiith a?oiith (p<0,05). Iaeii/ania i?aeaeuaiiy ai?noo ONA oa A2 ,iniaeeai a ae?oao oaco iaino?oaeueiiai oeeeeo, a oai?eo ia AeAIC ie aaaaea?ii i?iyaii ii?ooaiiy iaoai?cio cai?ioiiai ca’yceo. I?e AeAIC ia? i?noea aaniethoia oa a?aeiinia a?ia?ano?iaaiai?y e a?iii?iaanoa?iiai?y. Eiao?oe??io A2/I o oai?eo ia AeAIC aeuee, i?ae o eiio?ieuei?e a?oi?, o 8,7 ?ace a oie?eoe?iiao oaco iaino?oaeueiiai oeeeeo, ? a 9,3 ?ace a ethoa?iiao oaco (p<0,01). Naia oeae iieaciee, ia iaoo aeoieo, ? iaea?eueo ?ioi?iaoeaiei aeey ioe?iee ai?iiiaeueiiai aeenaaeaino i?e AeAIC. Aeyaeaii i?yio ei?aeyoe?eio caeaaei?noue i?ae ??aiai A2 a ae?oa?e oac? iaino?oaeueiiai oeeeeo ? nooiaiai aaaeeino? ee?i?/ii? ea?oeie AeAIC ?c eiao?oe??ioii ei?aeyoe?? 0,79±0,03, a oaeiae i?ae eiao?oe??ioii A2/I o ae?oa?e oac? iaino?oaeueiiai oeeeeo ? nooiaiai aaaeeino? ee?i?/ii? ea?oeie AeAIC ?c eiao?oe??ioii ei?aeyoe?? 0,41±0,08. E??i oiai, ie anoaiiaeee iayai?noue iaa?iaii? ei?aeyoe?eii? caeaaeiino? i?ae ??aiai I a ae?oa?e oac? iaino?oaeueiiai oeeeeo ? nooiaiai aaaeeino? ee?i?/ii? ea?oeie caoai?thaaiiy c eiao?oe??ioii ei?aeyoe?? -0,54±0,06. Oaeei /eiii, AeAIC — iie?ao?ieia?/iee i?ioean, yeee ?icaeaa?oueny ia oii? ai?iiiaeueieo ii?ooaiue o ae?iie c iaoyaeaiith niaaeeia?noth. Oaeoi?aie eiai ?eceeo ? i?ioan?ei? oe?aeeeaino?, ia?aiai-ineo?/ia iai?oaeaiiy, iani?eyoeea? iniaeeaino? n?iaeiiai oa ?ai?iaeoeoeaiiai aiaiiaco, a?eueo i?ci? oa o?eaaea noaiiaeaiiy iaino?oaeueiiai oeeeeo, iayai?noue noiooi?o a?iaeieia?/ieo, iae?iaiaeie?eiieo oa iai?iieo caoai?thaaiue. Oe? ae?iee iaaeinoaoiuei ii?ioi?iiaai? i?i iaoiaee ? caniae eiio?aoeaioe??, ia?aaaaeia a?eueo?noue c ieo ia ei?enoothoueny no/anieie iaoiaeaie, ui noai?th? aenieee ?ecee ianoaiiy iaieaiiaaii? aaa?oiino?. A iaoiaaiac? AeAIC iniiaio ?ieue a?ae?a?athoue oae? ai?iiiaeuei? ii?ooaiiy, ye a?ia?i?ieaeoeiai?y, i?aeaeuaiiy ??aiy aiiaaeio?iiieo ai?iii?a a?iio?co, aaniethoia oa a?aeiinia a?ia?ano?iaaiai?y e a?iii?iaanoa?iiai?y, oa ii?ooaiiy iaoai?cio cai?ioiiai ca’yceo a a?iio?ca?ii-y?/ieeia?e nenoai?. O aeai?e ?iaio? aia?oa aoei i?iaiae?ciaaii ai?iiiaeuei? aniaeoe a aeeiai?oe? aeei?enoaiiy ??cieo aeae?a IE oai?eie c aeeoocieie oi?iaie AeAIC. Aea/aiiy ai?iiiaeueiiai aiiainoaco i?iaiaeeeiny ia 6-8 aeaiue iaino?oaeueiiai oeeeeo ? ia 20-22 aeaiue i?ioyaii 6-ai, 12-ai, 24-ai i?nyoe?a aeei?enoaiiy i?aia?ao?a, a iio?i i?ioyaii 12-ai i?nyoey i?ney a?aei?ie eiio?aoeaioe??. Aiae?coth/e ?acoeueoaoe aea/aiiy aieeao ??cieo aeae?a IE ia noai ai?iiiaeueii? nenoaie oai?eo ia AeAIC, ie iaea?aeaee oae? aeai?: an? aeaee i?aeueieo ai?iiiaeueieo eiio?aoeaioea?a i?eai?/othoue aiiaaeio?iiio ooieoe?th a?iio?co a ae?iie, oai?eo ia AeAIC, a a?eueo?e i???, i?ae o eiio?ieuei?e a?oi?. Iiiioaci? EIE i?ecaiaeyoue aei cieaeaiiy ??aiy ONA o 2,2 ?ace na?aae oai?eo ia AeAIC ? a 1,4 ?ace a eiio?ieuei?e a?oi? /a?ac 2 ?iee canoinoaaiiy. EA cieaeo?oueny o 2,2 ? 1,7 ?ace a?aeiia?aeii. ??aaiue aiiaaeio?iiieo ai?iii?a ia ia? aeinoia??ii? a?aei?iiino? a?ae iieaciee?a eiio?ieueii? a?oie a ae?oa?e oac? iaino?oaeueiiai oeeeeo i?ioyaii onueiai ia??iaeo canoinoaaiiy eiio?aoeaioe??. O?eoaci? EIE o iaeiaio?e i??? i?eai?/othoue aiiaaeio?iiio ooieoe?th a?iio?co e a iniiaiiio aieeaathoue ia ONA, a?aeaoaa?oueny eiai cieaeaiiy a 1,8 ?ace a iniiai?e a?oi? e o 1,7 ?ace a eiio?ieuei?e. *eno? aanoaaaie ia?aaaaeii aieeaathoue ia EA, eiai ??aaiue cieaeo?oueny a 2,0 ?ace. Iiceoeaiee aieea iiiioacieo EIE ? i?i?-i?e? caa??aa?oueny i?ioyaii ?ieo i?ney neanoaaiiy eiio?aoeaioe??. Iaie aeyaeai? ?noioi? ?icoiaeaeaiiy uiaei aieeao ??cieo aeae?a ai?iiiaeueieo eiio?aoeaioea?a ia ??aaiue I?E. An? eiia?iiaai? IE aeeeeeathoue eiai i?aeaeuaiiy ye o eiio?ieueieo a?oiao, oae ? na?aae oai?eo ia AeAIC, i?ioyaii onueiai ia??iaeo canoinoaaiiy eiio?aoeaioe??. I?iaiaey/e aiae?c oeueiai aieeao EIE, ie aeyaeee ianooii? iniaeeaino?: i?aeaeuaiiy ??aiy I?E /a?ac aeaa ?iee aeei?enoaiiy EIE a?eueo i?ae ia 10,0 % a?ae ii/aoeiaiai a?aeaoaa?oueny caeaa?eueoiai (91,4 %) na?aae oeo oai?eo ia AeAIC, a yeeo ??aaiue oeueiai ai?iiio aei aeei?enoaiiy ai?iiiaeueii? eiio?aoeaioe?? noaiiaea 13,0 ia/ie oa a?eueoa. Ie aeyaeee iayai?noue i?yiiai ei?aeyoe?eiiai ca’yceo i?ae ??aiai I?E aei ii/aoeo aaeeaaiiy EIE oa nooiaiai eiai i?aeaeuaiiy /a?ac aeaa ?iee aeei?enoaiiy oeeo eiio?aoeaioea?a o oai?eo ia AeAIC (eiao?oe??io ei?aeyoe?? 0,45±0,07). *a?ac ??e i?ney a?aei?ie eiio?aoeaioe?? eiai ??aaiue iiaa?oa?oueny aei ii/aoeiaiai. A na?oia?e e?oa?aoo?? ie ciaeoee i?aeoaa?aeaeaiiy io?eiaieo iaie aeaieo noiniaii i?aeaeuaiiy ai?noo I?E i?ae /an o?eaaeiai canoinoaaiiy EIE (Aoaa?iaoi?ia A.A., 1994; Iaio?eiaa ?.A., 1993; Akerlund M., Rode A., 1993), aea iaoaiaoe/io caeaaei?noue nooiaiy eiai i?aeaeuaiiy a?ae ii/aoeiaiai ??aiy a oai?eo ia AeAIC ciaeaeaii aia?oa. *eno? aanoaaaie, iaaiaee, cieaeothoue ??aaiue I?E, ? oeae aoaeo caa??aa?oueny i?ioyaii ?ieo i?ney a?aei?ie eiio?aoeaioe??. An? aeaee ai?iiiaeueii? eiio?aoeaioe?? iiceoeaii aieeaathoue ia ??aaiue y?/ieeiaeo ai?iii?a o ae?iie ?c AeAIC, aea a ??ci?e i???. A?aeaoaa?oueny cieaeaiiy A2 ? i?aeaeuaiiy I, o iaeiaio?e i??? ae?aaeaia i?e aeei?enoaii? o?eoacieo EIE, o iaea?eueo?e — i?e canoinoaaii? i?i?-i?e?. Iaea?eueo ?ioi?iaoeaiei iieacieeii iiceoeaiiai aieeao ai?iiiaeueii? eiio?aoeaioe?? ia aaeain y?/ieeiaeo ai?iii?a o ae?iie ?c AeAIC ? eiao?oe??io A2/I a ae?oao oaco oeeeeo. Niinoa??aa?oueny aeinoia??ia cieaeaiiy oeueiai eiao?oe??ioa aaea /a?ac 6 i?nyoe?a canoinoaaiiy an?o aeae?a IE, ? iio?i a?aeaoaa?oueny eiai iiaeaeueoa ciaioaiiy. *a?ac 2 ?iee a?i cieaeo?oueny a 1,6 ?ace i?e aeei?enoaii? o?eoacieo EIE, o 1,8 ?ace i?e canoinoaaii? iiiioacieo eiio?aoeaioea?a, ? a 3,8 ?ace i?e aeei?enoaii? i?i?-i?e?. Oeae iiceoeaiee aoaeo ai?iiiaeueii? eiio?aoeaioe?? ia aaeain y?/ieeiaeo ai?iii?a o oai?eo ia AeAIC caa??aa?oueny i?ioyaii ?ieo i?ney a?aei?ie eiio?aoeaioe??. Eiao?oe??io A2/I o ae?oao oaco oeeeeo /a?ac ??e i?ney a?aei?ie eiio?aoeaioe?? aoa ieae/ei, i?ae aeo?aeiee, ia 25% o a?oi?, aea aeei?enoiaoaaeeny o?eoaci? EIE, ia 37,5% o oeo ae?iie, ui i?eeiaee iiiioaci? EIE, ? ia 42,9% o oeo, ui i?eeiaee i?i?-i?e?. Ca aeaieie /eneaiieo aaoi??a, ui aea/aee ieoaiiy ao?ieia?? oa iaoiaaiaco ianoiiao??, ano?iaaie ni?iiiaei? aeeeeeaoe i?ie?oa?aoe?th ai?oae?th aeueaaie, i?ioie?a, iineethaaoe aeoeai?noue o?a?iaeano?a ? aeeeeeaoe i?ie?oa?aoe?th niieo/ii? oeaieie iiei/ii? caeice. ?nioaaiiy iino?eii? ano?iaaiii? noeioeyoe?? oeaiei iiei/ii? caeice ca oiia iaaeinoaoiino? caoeniiai aoaeoo i?iaanoa?iio ia? iniiaia cia/aiiy a ?icaeoeo iaoieia?/iiai i?ioeano (Neaei?aiei E. I., 1991; Eocuei?i ?.A., 1991, Colocleanu M., 1995; Hoshi K. et al., 1995). Ie aaaaea?ii, ui ii?iae?caoe?y ai?iiiaeueiiai oiio i?ecaiaeeoue aei ciaioaiiy i?ie?oa?aoeaieo i?ioean?a o oeaieiao iiei/ii? caeice ? iiceoeaii? aeeiai?ee a noai? iiei/ieo caeic oa i?io?eaii? caoai?thaaiiy. Cieaeaiiy a?iaeieia?/ii? caoai?thaaiino? ? a?aenooi?noue i?ioyaii o?eaaeiai ia??iaeo /ano iaaaaeaii? aaa?oiino?, yea o ia?aaaaei?e a?eueoino? aeiaaee?a cae?i/o?oueny ia?a?eaaiiyi, oaeiae a?ae?a?athoue iiceoeaio ?ieue o oeueiio i?ioean?. A aeai?e ?iaio? ie aia?oa i?iaaee ii??aiyeueiee aiae?c aieeao ??cieo iaoiae?a oa aeae?a eiio?aoeaioe?? ia noai iiei/ieo caeic ? ia?aa?a AeAIC, a oaeiae aea/eee aoaeoeai?noue ? i?eeiyoi?noue ??cieo aeae?a eiio?aoeaioe?? aeey oeeo oai?eo o ii??aiyii? c eiio?ieueiith a?oiith. Ie aeyaeee, ui an? aeaee ai?iiiaeueii? eiio?aoeaioe?? ca oiia i?aaeeueiiai aeiai?o c o?aooaaiiyi ?iaeea?aeoaeueiiai ai?iiiaeueiiai noaoono iiceoeaii aieeaathoue ia noai iiei/ieo caeic oai?eo ia AeAIC ? ia?aa?a caoai?thaaiiy. A iaea?eueo?e i??? iiceoeaiee aoaeo a?ae canoinoaaiiy ai?iiiaeueii? eiio?aoeaioe?? niinoa??aa?oueny i?e aeei?enoaii? /enoeo aanoaaai?a. *a?ac 2 ?iee canoinoaaiiy eiio?aoeaioe?? iie?ioaiiy ee?i?/ii? ea?oeie caoai?thaaiiy a?aeaoaaeinue a 41,7% o II.A a?oi?, a 38,9% o II.A a?oi?, a 63,2% o II.A e o?eueee a 20,0% o III a?oi?. ??cieoey i?ae ??.A oa ???, a oaeiae i?ae ??.A oa ??? a?oiaie ? aeinoia??iith (?<0,05). Aeaeoaeaiiy niinoa??aaeinue a 8,3% o II.A a?oi?, a 8,3% o II.A a?oi?, ? a 18,4% o II.A a?oi?. A III a?oi? ia aoei aeiaaee?a aeaeoaeaiiy. Noaa?e?caoe?y i?io?eaiiy caoai?thaaiiy niinoa??aaeanue a 50,0%, a 50,0%, a 18,4%, ? a 52,5% a?aeiia?aeii. ?icoiaeaeaiiy i?ae ??,A oa ??? a?oiaie ? aeinoia??iei (?<0,05). Iia??oaiiy ia?aa?ao caoai?thaaiiy a?aecia/aii o?eueee a 1 iaoe??ioee II.A a?oie (2,8%) ? a 8 (20,0%) III a?oie. O 3 aeiaaeeao a III a?oi? (7,5%) a?aeaoany ia?ao?ae AeAIC o aoceoaaoo oi?io. O an?o a?oiao ia a?aecia/aii aeiaeiiai aeiaaeeo iae?ai?caoe??. A iaoiio aeine?aeaeaii? anoaiiaeaii, ui i?e o?eaaeiio (a?eueoa ?ieo) aeei?enoaii? EIE a?aeaoaa?oueny ca?eueoaiiy /anoioe aaeaeoi?a? a oai?eo ia AeAIC, ui, ia iaoo aeoieo, iia'ycaii c? noeioethth/ei aieeaii oeeo eiio?aoeaioea?a (a naia, ?o ano?iaaiiiai eiiiiiaioo) ia i?iaeoeoe?th I?E, a oaeiae i?aeaeuaiith /ooeea?noth iiei/ieo caeic aei oeueiai ai?iiio i?e AeAIC. *a?ac ??e i?ney a?aei?ie eiio?aoeaioe?? /anoioa aaeaeoi?a? a oeeo ae?iie iiaa?ioeanue aei ii/aoeiaiai ??aiy. I?iaiaey/e ii??aiyeueio oa?aeoa?enoeeo ??cieo aeae?a IE, ie ae?eoee aeniiaeo, ui iaea?eueoee iiceoeaiee aieea ia ai?iiiaeueiee aaeain ? ia?aa?a caoai?thaaiiy i?e a?aenooiino? iaaaoeaiiai aieeao iathoue /eno? aanoaaaie. Ia iaoo aeoieo, i?i?-i?e? ? iaoiaeii aeai?o aeey oeeo ae?iie. Iiceoeaiee aieea ai?iiiaeueii? eiio?aoeaioe?? ia noai iiei/ieo caeic i?e AeAIC caa??aa?oueny i?ioyaii ?ieo i?ney a?aei?ie eiio?aoeaioe??. Ia aeyaeaii aeinoia??ii? ??cieoe? a noai? iiei/ieo caeic /a?ac 2 ?iee canoinoaaiiy IE ? /a?ac ??e i?ney ?o a?aei?ie. O III a?oi?, aea ae?iee i?iaeiaaeoaaee ei?enooaaoeny o?aaeeoe?eieie iaoiaeaie eiio?aoeaioe??, a?aecia/a?oueny iaaaoeaia aeeiai?ea i?io?eaiiy caoai?thaaiiy ca inoaii?e ??e ua a 3 aeiaaeeao (7,5%). Ie aaaaea?ii, ui o?eaaea (a?eueoa ?ieo) aeei?enoaiiy o?aaeeoe?eieo iaoiae?a eiio?aoeaioe?? ae?ieaie c AeAIC i?ecaiaeeoue aei iia??oaiiy noaio iiei/ieo caeic oa i?io?eaiiy caoai?thaaiiy, ? a ?yae? aeiaaee?a — aei oi?ioaaiiy aoceoaaoeo oi?i AeAIC ? iaiao?aeiino? iia?aoeaiiai ao?o/aiiy. Iaeiei c iniiaieo aeiia aei aoaeue-yeiai iaoiaeo eiio?aoeaioe?? ? eiai aeniea aoaeoeai?noue, ui ioe?ith?oueny ca /eneii aaa?oiinoae ia 100 ae?iie/?ie?a (?iaeaen Ia?ey). Iaoa aeine?aeaeaiiy i?aeoaa?aeeei a?eueo aenieo aoaeoeai?noue ai?iiiaeueii? eiio?aoeaioe?? a ii??aiyii? c o?aaeeoe?eieie iaoiaeaie. Ee?i?/ia aoaeoeai?noue iiiioacieo EIE ? i?i?-i?e? neeaea 0 aaa?oiinoae ia 100 ae?iie/?ie?a, aai 100,0%, ye a iniiaieo a?oiao, oae ? a eiio?ieueieo. A iaeiiio aeiaaeeo a II.A a?oi? ia /aoaa?oiio i?nyoe? aeei?enoaiiy i?aia?aoo o?eea?ea? ianoaea aaa?oi?noue o ca'yceo c ii?ooaiiyi noaie i?eeiio i?aia?aoo (i?iione oaaeaoie). Ee?i?/ia aoaeoeai?noue o?eoacieo EIE neeaea 1,4 aaa?oiinoae ia 100 ae?iie/?ie?a, aai 98,6%, a iniiai?e a?oi?, ? 100,0% a eiio?ieuei?e. O III a?oi? ca 2 ?iee ianoaei 12 iaaaaeaieo aaa?oiinoae, c ieo 10 cae?i/eeeny ooo/ieie aai?oaie. O 5 aeiaaeeao i?ney ia?a?eaaiiy aaa?oiino? a?aeaoeiny iia??oaiiy ia?aa?ao AeAIC, a iaeiiio aeiaaeeo — ia?ao?ae o aoceoaaoo oi?io. Aoaeoeai?noue o?aaeeoe?eieo iaoiae?a eiio?aoeaioe?? neeaea 15,0 aaa?oiinoae ia 100 ae?iie/?ie?a, aai 85,0%. Aiae?c i?eeiyoiino? IE aeey oai?eo ia AeAIC, /anoioe ?icaeoeo ? oa?aeoa?o iia?/ieo aoaeo?a iieacaa ?oith aenieo i?eeiyoi?noue, iia'ycaio, ca iaoeie aeaieie, ?c aenieei eiio?aoeaioeaiei aoaeoii, aeinooii?noth, aaceiooiaiith aeaea/ath a oeaio?? ieaioaaiiy n?i'?, ae?aaeaiei e?eoaaeueiei aoaeoii, iecueeei a?aenioeii iaaaoeaieo iia?/ieo aoaeo?a. Aei e?ioey ia?oiai ?ieo ei?enooaaoeny ai?iiiaeueiith eiio?aoeaioe??th i?iaeiaaeoaaee 96,7 % ae?iie eiio?ieueii? a?oie ? 97,5 % oai?eo ia AeAIC, aei e?ioey ae?oaiai ?ieo 93,3 % ? 93,2 % a?aeiia?aeii. Ai?iiiaeueia eiio?aoeaioe?y ? ?aeeiei aeaeii ?c i?aeoe/ii 100% aoaeoeai?noth (Aiae ?.A., 1997; Iaio?eiaa ?.A., 1993), ui i?aeoaa?aeaeo?oueny iaoei aeine?aeaeaiiyi. *anoioa iia?/ieo aoaeo?a ia ia?aaeuo? oaeo a eiio?ieuei?e a?oi?. Ana oea aeicaiey? ?aeiiaiaeoaaoe canoinoaaiiy ai?iiiaeueii? eiio?aoeaioe?? ae?ieai c AeAIC. Aea/ath/e aieea ??cieo aeae?a eiio?aoeaioe?? ia a?iaeieia?/io caoai?thaai?noue ? ?ai?iaeoeoeaio ooieoe?th ae?iie ?c AeAIC, ie io?eiaee ianooii? ia 67,4%; a ??? a?oi? (a?oi? ii??aiyiiy) c?inea ia 10,1%. ??cieoey i?ae iniiaiith oa a?oiith ii??aiyiiy aeinoia??ia (?<0,01). E?euee?noue ia?a?aaieo aaa?oiinoae a?aeiia?aeii cieceeanue a 9,0 ?ac?a, aai ia 88,9%, oa a 1,5 ?ace, aai ia 37,8%. ??cieoey i?ae a?oiaie oaeiae aeinoia??ia (?<0,05). Acaaae? canoinoaaiiy ai?iiiaeueii? eiio?aoeaioe?? na?aae 162 oai?eo ia AeAIC aeicaieeei cieceoe a?iaeieia?/io caoai?thaai?noue a 2,0 ?ace, aai ia 50,9%, o oiio /ene? /anoioo caaino?aiue caiaeueieo i?ioean?a i?aai?a iaeiai oaco a 2,0 ?ace, aai ia 43,4%, caaino?aiue aiaeiiao??ico a 1,7 ?ace, aai ia 42,2%, ae?aaiinoe/ieo aeoe??aaiue a 3,6 ?ace, aai ia 72,5%, ii?ooaiue iaino?oaeueiiai oeeeeo a 1,8 ?ace, aai ia 43,1%. *enei ia?a?aaieo aaa?oiinoae o oeeo ae?iie cieceeiny a 4,0 ?ace, aai ia 74,4%. I?iaaaeai? aeine?aeaeaiiy aeaee iai i?aenoaae ?ic?iaeoe aeai?eoi ?iaeea?aeoaeueiiai aeeoa?aioe?eiaaiiai aeiai?o iaoiae?a i?io?eaeoeee iaieaiiaaii? aaa?oiino? aeey oai?eo aeeoocieie oi?iaie AeAIC (?enoiie). Eiai i?aeoe/ia canoinoaaiiy a AeAe?OeIIAe i?ioyaii o?ueio ?ie?a aeicaieeei cieceoe e?euee?noue ooo/ieo aai?o?a o oe?e a?oi? ae?iie c 19,8% aei 4,5%, a a?iaeieia?/io caoai?thaai?noue c 72,0% aei 35,9%. Ie niiae?aa?iiny, ui cai?iiiiiaaiee iaie aeai?eoi ?iaeea?aeoaeueiiai aeiai?o eiio?aoeaioe?? aeey ae?iie c aeeoocieie oi?iaie AeAIC aeiiiiiaea i?aeoe/iei e?ea?yi oaeaeei ? i?aaeeueii ?aeiiaiaeoaaoe iaoiae eiio?aoeaioe?? aac oeiaee ? c iaeneiaeueiith ei?enoth aeey caei?ia'y iaoe??ioie. AENIIAEE Anoaiiaeaii, ui a 75,6% oai?eo ia AeAIC iathoue i?noea iani?eyoeea? iniaeeaino? ?ai?iaeoeoeaiiai aiaiiaco, oe? ae?iee iaaeinoaoiuei ii?ioi?iiaai? i?i iaoiaee ? caniae eiio?aoeaioe??, ui noai?th? aenieee ?ecee ianoaiiy iaieaiiaaii? aaa?oiino?. Ni?aa?aeiioaiiy ia?a?aaieo aaa?oiinoae ? iieia?a o oe?e a?oi? ae?iie aeoaea aeniea ? neeaaea? 2,1 ( 1, iaaee/i? aai?oe a aiaiiac? iathoue 79,6%. O ca'yceo c oeei o 93,7% oai?eo niinoa??aathoueny iaoieia?/i? ci?ie a noai? ?ai?iaeoeoeaiiai caei?ia'y. O oai?eo ia AeAIC niinoa??aathoueny nooo?a? ci?ie a a?iio?ca?ii-y?/ieeia?e nenoai?, na?aaeiy eiioeaio?aoe?y ONA ? EA ia?aaeuo? iieacieee caei?iaeo ae?iie a?aeiia?aeii a 1,7 ? 2,3 ?ace, ??aaiue I?E aeuee a 2,6 ?ace, ia? i?noea aaniethoia oa a?aeiinia a?ia?ano?iaaiai?y ? a?iii?iaanoa?iiai?y. A ethoa?iiao oaco iaino?oaeueiiai oeeeeo ??aaiue A2 ia?aaeuo? iieacieee caei?iaeo ae?iie o 1,8 ?ace, ??aaiue I cieaeaiee o 2,1 ?ace, eiao?oe??io A2/I aeuee, i?ae a eiio?ieuei?e a?oi?, o 9,3 ?ace. Anoaiiaeaii i?yio ei?aeyoe?eio caeaaei?noue i?ae nooiaiai aaaeeino? ee?i?/ii? ea?oeie AeAIC ? ??aiai A2 (0,79±0,03), a oaeiae eiao?oe??ioii A2/I (0,41±0,08), o ae?oa?e oac? iaino?oaeueiiai oeeeeo. Anoaiiaeaii oaeiae iaa?iaio ei?aeyoe?eio caeaaei?noue i?ae ??aiai I o ae?oa?e oac? iaino?oaeueiiai oeeeeo ? nooiaiai aaaeeino? ee?i?/ii? ea?oeie caoai?thaaiiy (-0,54±0,06). I?aeuei? eiio?aoeaioeae iiceoeaii aieeaathoue ia noai a?iioeca?ii-y?/ieeiai? nenoaie oai?eo ia AeAIC, ui i?ecaiaeeoue aei ciaioaiiy i?ie?oa?aoeaieo i?ioean?a o oeaieiao iiei/ii? caeice, iie?ioaiiy noaio iiei/ieo caeic ? i?io?eaiiy caoai?thaaiiy. O iaea?eueo?e i??? oeth ae?th iaaeathoue /eno? aanoaaaie. Iiceoeaiee aieea caa??aa?oueny i?ioyaii ?ieo i?ney a?aei?ie eiio?aoeaioe??. ? ?noioi? ?icoiaeaeaiiy uiaei aieeao ??cieo aeae?a ai?iiiaeueieo eiio?aoeaioea?a ia ??aaiue i?ieaeoeio. Eiia?iiaai? IE aeeeeeathoue i?aeaeuaiiy ai?noo ai?iiio, aea /a?ac ??e i?ney a?aei?ie eiio?aoeaioe?? eiai ??aaiue iiaa?oa?oueny aei ii/aoeiaiai. *eno? aanoaaaie cieaeothoue ??aaiue i?ieaeoeio, ? oeae aoaeo caa??aa?oueny i?ioyaii ?ieo i?ney a?aei?ie eiio?aoeaioe??. I?aeaeuaiiy ??aiy i?ieaeoeio /a?ac aeaa ?iee aeei?enoaiiy EIE a?eueo i?ae ia 10,0 % a?ae ii/aoeiaiai a?aeaoaa?oueny caeaa?eueoiai (91,4 %) na?aae oai?eo ia AeAIC, a yeeo ??aaiue oeueiai ai?iiio aei aeei?enoaiiy ai?iiiaeueii? eiio?aoeaioe?? noaiiaea 13,0 ia/ie oa a?eueoa. Anoaiiaeaii i?yiee ei?aeyoe?eiee ca'ycie i?ae ??aiai I?E aei ii/aoeo aaeeaaiiy EIE oa nooiaiai eiai i?aeaeuaiiy /a?ac aeaa ?iee aeei?enoaiiy oeeo eiio?aoeaioea?a o oai?eo ia AeAIC (0,45±0,07). I?aeuei? eiio?aoeaioeae c iecueeei ai?noii noaoaaeo noa?i?ae?a iiaeooue aeei?enoiaoaaoeny a oai?eo ia AeAIC c o?aooaaiiyi ?iaeea?aeoaeueiiai ai?iiiaeueiiai noaoono ye iaae?ei? ? aacia/i? iaoiaee i?io?eaeoeee iaieaiiaaii? aaa?oiino?. Canoinoaaiiy cai?iiiiiaaiiai aeai?eoio ?iaeea?aeoaeueiiai aeeoa?aioe?eiaaiiai aeiai?o iaoiae?a eiio?aoeaioe?? aeey oai?eo ia AeAIC aeicaiey? cieceoe e?euee?noue ooo/ieo aai?o?a o oe?e a?oi? ae?iie ?c 19,8% aei 4,5%, a a?iaeieia?/io caoai?thaai?noue ?c 72,0% aei 35,9%. I?AEOE*I? ?AEIIAIAeAOe?? An? ae?iee ?ai?iaeoeoeaiiai a?eo c aeeoociith aeia?iye?niith a?ia?ieac??th iiei/ieo caeic neeaaeathoue a?oio ?eceeo uiaei ianoaiiy iaieaiiaaii? aaa?oiino? e iiaeii? ciaoiaeeoeny i?ae aeeniaina?iei iaaeyaeii a iaiieiaa, a oaeiae a eaa?iao? ieaioaaiiy n?i'?. Aeai?o iaoiaea i?io?eaeoeee iaieaiiaaii? aaa?oiino? iaoe??ioeai ?c AeAIC iiaeiia ia?aaeoaaoe ai?iiiaeueia ianoaaeaiiy (I?E, A2, I ia 20 – 22 aeaiue iaino?oaeueiiai oeeeeo). I?aeuei? eiio?aoeaioeae c iecueeei ai?noii noaoaaeo noa?i?ae?a iiaeooue aeei?enoiaoaaoeny ye iaae?ei? ? aacia/i? iaoiaee eiio?aoeaioe?? a ae?iie ?c AeAIC c o?aooaaiiyi a?eo, ?iaeea?aeoaeueiiai ai?iiiaeueiiai noaoono e i?e a?aenooiino? caaaeueiii?eeiyoeo i?ioeiieacaiue. Aeey iaoe??ioie iieiaeoa 35 ?ie?a i?e a?aenooiino? aaeaeoi?a? oa ??ai? i?ieaeoeio ieae/a 13,0 ia/ie iiaeeeaa canoinoaaiiy eiia?iiaaieo IE c iecueeei ai?noii noaoaaeo noa?i?ae?a oeio ia?aaeii, ei-oaiaiie, i?e?ia?iii, o?eea?ea?, o?ec?noii, o?e-?aaie. I?e iiya? aaeaeoi?a? i?ae /an canoinoaaiiy oeeo eiio?aoeaioea?a ?aeiiaiaeo?oueny ia?ao?ae aei /enoeo aanoaaai?a. I?e iayaiino? ii/aoeiai? aaeaeoi?a? aai ??ai? I?E 13,0 ia/ie ? aeua ?aeiiaiaeo?oueny aeei?enoaiiy /enoeo aanoaaai?a oeio eiio?io?i, aenethoii, ia?ao. Aeey ae?iie ?c AeAIC noa?oa 35 ?ie?a c iaoith eiio?aoeaioe?? oa e?eoaaiiy ?aeiiaiaeo?oueny canoinoaaiiy i?i?-i?e? ye iaoiae aeai?o. NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? Eiio?aoeaioeey i?e aeeooociie aeenai?iiiaeueiie aeia?ieacee iiei/iuo aeaeac // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.—1998.—?21.—N.88-91 (niaao.: *aeea A.E., Eaaoaiei A.I.). Aieea ai?iiiaeueii? eiio?aoeaioe?? ia noai iiei/ieo caeic i?e aeeoocieo oi?iao ianoiiao?? // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.—1998.—?6.—N.114-116 (ni?aaao.: *aeea A.E., Eaaoaiei A.I.). Nia?aiaiiua i?aaenoaaeaiey i aeia?iea/anoaaiiie aeia?ieacee iiei/iuo aeaeac // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.—1999.—? 1.—N.11-17 (niaao.: *aeea A.E., sseiaaoe TH.E., Eaaoaiei A.I.). Aeaye? iniaeeaino? eaeoaoe?? na?aae ii?iae?eue, ye? ?ai?oa aaeeaaee ??ci? iaoiaee eiio?aoeaioe?? // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.—1999.—? 4.—N.26-29 (ni?aaao. Ii?iciaa I.A.). ?ai?iaeoeoeaiay ooieoeey aeaiuei ia oiia ianoiiaoee // Aeooaeueiua aii?inu eeeie/aneiai aeooa?noaa e aeiaeieiaee: THaeeaeiue nai?iee iao/iuo o?oaeia eaoaae?u aeooa?noaa e aeiaeieiaee OOA.—Aeiiaoee, 1995.—N.103-107 (niaao. Ii?iciaa I.A., Nethna?ue O.E.). I?ioeeaeoeea iaaeaeaoaeueiie aa?aiaiiinoe i?e aeia?iea/anoaaiiuo aeenai?iiiaeueiuo caaieaaaieyo iiei/iuo aeaeac // Aii?inu yenia?eiaioaeueiie e eeeie/aneie iaaeeoeeiu (nai?iee noaoae).—Aeiiaoee, 1998.—Aui.2.—O.1.—N.97-100. (niaao. Aieoayoieeiaa E.A.). Aieea ii?ooaiue eaeoaoe?? ia aeieeiaiiy oa ia?aa?a ianoiiao?? // O c’?cae aeooa??a-a?iaeieia?a Oe?a?ie.— Oace aeiiia?aeae. — Iaeana, 1996. — N.135 (ni?aaao. Aaeaiiaa A.I., Oii/aiei A.I.). Aeeiai?ea aeyao ianoiiao?? na?aae a?iaeieia?/ieo oai?eo a caeaaeiino? a?ae a?eo oa /ano aeieeiaiiy a?iaeieia?/iiai caoai?thaaiiy // O c’?cae aeooa??a-a?iaeieia?a Oe?a?ie: Oace aeiiia?aeae.—Iaeana, 1996.—N.135 (ni?aaao. Eoa?ae E.A.). AIIOAOe?ss Eana/ei N.A. I?io?eaeoeea iaieaiiaaii? aaa?oiino? i?e aeeooci?e aeia?iye?ni?e a?ia?ieac?? iiei/ieo caeic. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.01 - aeooa?noai ? a?iaeieia?y. ?inoeooo iaae?ao???, aeooa?noaa oa a?iaeieia?? AII Oe?a?ie, Ee?a, 1999. ?iaioa i?enay/aia ieoaiiyi caa?aaeaiiy ?ai?iaeoeoeaiiai caei?ia'y, cieaeaiiy /enea iaaee/ieo aai?o?a, a?iaeieia?/ii? caoai?thaaiino? na?aae ae?iie ?c aeia?iye?niith a?ia?ieac??th iiei/ieo caeic (AeAIC). Aea/aii iniaeeaino? ?ai?iaeoeoeaiiai aiaiiaco, aeei?enoiaoaaieo iaoiae?a eiio?aoeaioe??, a oaeiae noai a?iio?ca?ii-y?/ieeiai? nenoaie a 162 oai?eo ia AeAIC. Aeiaaaeaii iiceoeaiee aieea i?aeueieo eiio?aoeaioea?a ia ai?iiiaeueiee aiiainoac, noai iiei/ieo caeic ? ia?aa?a caoai?thaaiiy. ?ic?iaeaii ? iaoeiai iaa?oioiaaii aeai?eoi ?iaeea?aeoaeueiiai aeeoa?aioe?eiaaiiai aeiai?o iaoiae?a eiio?aoeaioe?? aeey oai?eo aeeoocieie oi?iaie AeAIC, canoinoaaiiy yeiai aeicaiey? cieceoe /anoioo ooo/ieo aai?o?a o oe?e a?oi? ae?iie c 19,8% aei 4,5%, a a?iaeieia?/io caoai?thaai?noue c 72,0% aei 35,9%. Eeth/ia? neiaa: aeia?iye?nia a?ia?ieac?y iiei/ieo caeic, eiio?aoeaioe?y, ?ai?iaeoeoeaia caei?ia'y, ai?iiiaeueiee aiiainoac, i?aeuei? eiio?aoeaioeae. AIIIOAOeEss Eana/ei N.A. I?ioeeaeoeea iaieaie?oaiie aa?aiaiiinoe i?e aeeooociie aeia?iea/anoaaiiie aeia?ieacee iiei/iuo aeaeac. - ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.01 – aeooa?noai e aeiaeieiaey. Einoeooo iaaeeao?ee, aeooa?noaa e aeiaeieiaee AII Oe?aeiu, Eeaa, 1999. ?aaioa iinayuaia aii?inai nio?aiaiey ?ai?iaeoeoeaiiai caei?iauey, nieaeaiey /enea iaaeeoeeineeo aai?oia, aeiaeieiae/aneie caaieaaaaiinoe n?aaee aeaiuei n aeia?iea/anoaaiiie aeia?ieaceae iiei/iuo aeaeac (AeAIAE). I?iaaaeai eeeieei-noaoenoe/aneee aiaeec iniaaiiinoae aiaiiaca, ?ai?iaeoeoeaiiai caei?iauey, eniieuecoaiuo iaoiaeia eiio?aoeaioeee, ninoiyiey aeiioeca?ii-ye/ieeiaie nenoaiu a aeeiaieea iaino?oaeueiiai oeeeea e a caaeneiinoe io noaiaie au?aaeaiiinoe eeeie/aneie ea?oeiu AeAIAE; enneaaeiaaii aeeyiea ?acee/iuo iaoiaeia e aeaeia eiio?aoeaioeee ia ai?iiiaeueiue aaeain aieueiuo AeAIAE, ninoiyiea iiei/iuo aeaeac e oa/aiea caaieaaaiey. Ianeaaeiaaiu 222 aeaiueiu ?ai?iaeoeoeaiiai aic?anoa, ec eioi?uo 118 — aieueiua AeAIAE, i?eieiaaoea i?aeueiua eiio?aoeaioeau (IE) o?ao aeaeia (iiiioaciua, o?aooaciua e ieie-ieee), 44 — aieueiua AeAIAE, eniieueciaaaoea n oeaeueth eiio?aoeaioeee oae iacuaaaiua “o?aaeeoeeiiiua” iaoiaeu, e 60 — caei?iaua aeaiueiu, i?eieiaaoea IE. Auyaeaii, /oi oaeoi?aie ?enea AeAIAE yaeythony i?ioanneiiaeueiua a?aaeiinoe, iaaeaaii?eyoiua iniaaiiinoe naiaeiiai e ?ai?iaeoeoeaiiai aiaiiaca, aieaa iicaeiaa e i?iaeieaeeoaeueiia noaiiaeaiea iaino?oaeueiiai oeeeea, iaee/ea niioonoaothueo aeiaeieiae/aneeo, iae?iyiaeie?eiiuo e iaiaiiuo caaieaaaiee. Yoe aeaiueiu iaaeinoaoi/ii i?ieioi?ie?iaaiu i iaoiaeao e niiniaao eiio?aoeaioeee, iiaeaaeythuaa aieueoeinoai ec ieo ia iieuecothony nia?aiaiiuie iaoiaeaie, /oi nicaeaao aunieee ?ene ianooieaiey iaieaie?oaiie aa?aiaiiinoe. Niioiioaiea i?a?aaiiuo aa?aiaiiinoae e ?iaeia a yoie a?oiia aeaiuei i/aiue aunieia e ninoaaeyao 2,1 ( 1, 93,7% ec ieo eiatho iaoieiae/aneea eciaiaiey a ninoiyiee ?ai?iaeoeoeaiiai caei?iauey. Onoaiiaeaii, /oi a iaoiaaiaca AeAIC iniiaioth ?ieue ea?atho oaeea ai?iiiaeueiua ia?ooaiey, eae aeia?i?ieaeoeiaiey, iiauoaiea o?iaiy aiiaaeio?iiiuo ai?iiiia aeiioeca, aaniethoiay e ioiineoaeueiay aeia?ano?iaaiaiey e aeiii?iaanoa?iiaiey, a oaeaea ia?ooaiea iaoaiecia ia?aoiie nayce a aeiioeca?ii-ye/ieeiaie nenoaia. Auyaeaia i?yiay ei??aeyoeeiiiay caaeneiinoue iaaeaeo o?iaiai yno?aaeeiea ai aoi?ie oaca iaino?oaeueiiai oeeeea e noaiaiueth au?aaeaiiinoe eeeie/aneie ea?oeiu AeAIC n eiyooeoeeaioii ei??aeyoeee 0,79±0,03, a oaeaea iaaeaeo eiyooeoeeaioii yno?aaeeie/i?iaanoa?ii ai aoi?ie oaca iaino?oaeueiiai oeeeea e noaiaiueth au?aaeaiiinoe eeeie/aneie ea?oeiu AeAIC n eiyooeoeeaioii ei??aeyoeee 0,41±0,08. E?iia oiai, onoaiiaeaii iaee/ea ia?aoiie ei??aeyoeeiiiie caaeneiinoe iaaeaeo o?iaiai i?iaanoa?iia ai aoi?ie oaca iaino?oaeueiiai oeeeea e noaiaiueth au?aaeaiiinoe eeeie/aneie ea?oeiu caaieaaaiey n eiyooeoeeaioii ei??aeyoeee -0,54±0,06. I?iaaaeaia n?aaieoaeueiay ioeaiea aeeyiey ?acee/iuo iaoiaeia eiio?aoeaioeee e ?aciuo aeaeia IE ia ninoiyiea aeiioeca?ii-ye/ieeiaie nenoaiu e oa/aiea AeAIAE a aeeiaieea a oa/aiea aeaoo eao i?eiaiaiey eiio?aoeaioeee e a oa/aiea aiaea iinea a? ioiaiu. Aeieacaii iieiaeeoaeueiia aeeyiea i?aeueiuo eiio?aoeaioeaia ia ai?iiiaeueiue aiiainoac, ninoiyiea iiei/iuo aeaeac e oa/aiea caaieaaaiey i?e oneiaee eiaeeaeaeoaeueiiai aeeooa?aioee?iaaiiiai iiaeai?a. Auyaeaii io?eoeaoaeueiia aicaeaenoaea ia ninoiyiea iiei/iuo aeaeac aieueiuo n AeAIAE aeeeoaeueiiai (aieaa aiaea) i?eiaiaiey oaeeo iaoiaeia eiio?aoeaioeee, eae aa?uea?iue, ?eoie/aneee, coitus interruptus eee eo ni/aoaiey. Iiaeoaa?aeaeaia aieaa aunieay (98,6-100,0%) eeeie/aneay yooaeoeaiinoue ai?iiiaeueiie eiio?aoeaioeee ii n?aaiaieth n o?aaeeoeeiiiuie iaoiaeaie, yooaeoeaiinoue eioi?uo ninoaaeea 85,0%. *anoioa e oa?aeoa? iiai/iuo yooaeoia i?e eniieueciaaiee IE ia i?aauoaee oaeiaoth o caei?iauo aeaiuei e auee ieieiaeueiuie. Ana auoaneacaiiia iicaieeei ?aeiiaiaeiaaoue i?eiaiaiea IE aeey i?ioeeaeoeee iaieaie?oaiie aa?aiaiiinoe o aeaiuei n AeAIAE. Ia iniiaaiee i?iaaaeaiiuo enneaaeiaaiee ?ac?aaioai, iao/ii iainiiaai e i?aaeeiaeai aeey i?aeoe/aneiai eniieueciaaiey neoaeaaie ieaie?iaaiey naiuee, aeooa?aie-aeiaeieiaaie, iieieiaaie e oe?o?aaie aeai?eoi eiaeeaeaeoaeueiiai aeeooa?aioee?iaaiiiai iiaeai?a iaoiaeia eiio?aoeaioeee aeey aieueiuo aeeooociuie oi?iaie AeAIAE, i?eiaiaiea eioi?iai iicaieyao nieceoue /anoioo eneonnoaaiiuo aai?oia a yoie a?oiia aeaiuei n 19,8% aei 4,5%, aeiaeieiae/aneoth caaieaaaaiinoue n 72,0% aei 35,9%. Eeth/aaua neiaa: aeia?iea/anoaaiiay aeia?ieacey iiei/iuo aeaeac, eiio?aoeaioeey, ?ai?iaeoeoeaiia caei?iauea, ai?iiiaeueiue aiiainoac, i?aeueiua eiio?aoeaioeau. SUMMARY Lasachko S.A. Prevention of unplanned pregnancy at diffuse benigh breast hiperplasia. - Manuscript. Thesis for scientific degree of candidate of medical sciences in specia-lity 14.01.01 – Obstetrics and Gynaecology. - The Institute of Pediatrics, Obstetrics and Gynaecology AMS of Ukraine, Kyiv, 1999. This scientific work is devoted to the question of reproductive health preservation, reducing the number of medical abortions, gynaecological mobidity rate among women with benigh breast hiperplasia (BBH). The particularities of reproductive anamnesis, methods of contraception in use, and hypophysis-ovarian system state on 162 patients with BBH have been studied. The positive influence of oral contraceptives on hormonal homeostasis, state of the breast and course of a disease has been demonstrated. The algorythm of the individual differentiated quest of the contraception methods for patients with diffuse forms of BBH has been elaborated and scientifically attested. The use of this algorythm makes possible to reduce the number of medical abortions in this group of women from 19,8% ti 4,5%, and mobidity rate from 72,0% ti 35,9%. Key words: benigh breast hiperplasia, contraception, reproductive health, hormonal homeostasis, oral contraceptives. IA?AE?E OIIAIEO NEI?I*AIUe AeAIC — aeia?iye?nia a?ia?ieac?y iiei/ieo caeic AeAe?OeIIAe — Aeiiaoeueeee aea?aeaaiee ?aa?iiaeueiee oeaio? ioi?iie iaoa?einoaa oa aeeoeinoaa A2 — ano?aae?ie EIE — eiia?iiaai? i?aeuei? eiio?aoeaioeae EA — ethoa?i?coth/ee ai?iii IE — i?aeuei? eiio?aoeaioeae I — i?iaanoa?ii I?E — i?ieaeoei ONA — oie?eoeinoeioethth/ee ai?iii

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