Патогенетичне обгрунтування застосування тренталу та тіотриазоліну при лікуванні гострого панкреатиту (експериментально-клінічне дослідження): Автореф

Iiiinoa?noai ioi?iie caei?ia’y oe?a?ie

E?einueeee aea?aeaaiee iaaee/iee oiiaa?neoao ii. N.i.Aai?ai?anueeiai

Oiii/eIi Iaai Iaaiiae/

OAeE
616.37-002.085+615.25

Iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy o?aioaeo oa oiio?eacieiio i?e
eieoaaiii aino?iai iaie?aaoeoo (aenia?eiaioaeueii-eeiiI/ia
aeineiaeaeaiiy)

14.01.03 — oi?o?aiy

Aaoi?aoa?ao aeena?oaoei? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Niioa?iiieue — 1999

Aeena?oaoeiy ? ?oeiienii

?iaioo aeeiiaii o E?einueeiio aea?aeaaiiio iaaee/iiio oiiaa?neoaoi ii.
N.I. Aai?ai?anueeiai Iiienoa?noaa ioi?iie caei?ia’y Oe?a?ie.

Iaoeiaee ea?iaiee: aeieoi? iaaee/ieo iaoe, i?ioani? NOA?INAE Aieoi?
Ieeieaeiae/, E?einueeee aea?aeaaiee iaaee/iee oiiaa?neoao ii. N.I.
Aai?ai?anueeiai, caaiaeoaa/ eaoaae?ith oi?o?ai/ieo oai?ia OII c eo?nii
oaeoeueoaonueei? oi?o?ai?.

Ioioeieii iiiiaioe: Caneoaeaiee aeiy/ iaoee i oaoiiee Oe?a?ie, aeieoi?
iaaee/ieo iaoe, i?ioani? EoiaeueoeIa Aieiaeeie? Iaaiiae/, Oa?ueeianueeee
aea?aeaaiee iaaee/iee oiiaa?neoao IIC Oe?a?ie, caaiaeoth/ee eaoaae?ith
oi?o?ai/ieo oai?ia.

aeieoi? iaaee/ieo iaoe, i?ioani? Aeanyoa?ee Aieiaeeie? Iaaiiae/,
Aeiii?iiao?ianueea aea?aeaaia iaaee/ia aeaaeaiiy IIC Oe?a?ie,
caaiaeoth/ee eaoaae?ith oi?o?ai?, o?aaiaoieiai? oa i?oiiaaei?
oaeoeueoaoo iineyaeeieiiii? inaioe.

I?iaiaeia onoaiiaa- Haoeiai-aeineiaeiee iinoeooo eeiii/ii? oa
aenia?eiaioaeueii? oi?o?ai? AIH Oe?a?ie, i. Ee?a.

Caoeno aiaeaoaeaoueny 29.02.2000?ieo i 13 aiaeeii ia caniaeaiii
Niaoeiaeiciaaii? A/aii? ?aaee E 52.600.02 o E?einueeiio aea?aeaaiiio
iaaee/iiio oiiaa?neoaoi ii. N.I. Aai?ai?anueeiai Iiiinoa?noaa ioi?iie
caei?ia’y Oe?a?ie (95006 i. Niioa?iiieue, Aoeueaa? Eaiiia 5/7).

C aeena?oaoei?th iiaeia iciaeiieoeny o aiaeiioaoei E?einueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ii. N.I. Aai?ai?anueeiai (95006 i.
Niioa?iiieue, Aoeueaa? Eaiiia 5/7).

Aaoi?aoa?ao ?icineaii 28.01.2000 ?ieo.

A/aiee nae?aoa? Niaoeiaeiciaaii? ?aaee,

aeieoi? iaaee/ieo iaoe, i?ioani?
I.I.Ai?eoi.

Caaaeueia oa?aeoa?enoeea ?iaioe

Aeooaeueiinoue oaie

Aino?ee iaie?aaoeo (AI) ? oyaeeith iaoieiai?th i iaeaaeeoue aei iaeii??
c iaeaaaeeeaioeo i?iaeai aeno?aii? oi?o?ai? (A.E.Eoiaeueoeia, 1988;
A.H.Noa?inae, 1990; M.H.Shoenberg, 1995; A.A.Oaeeiia, I.A.He/eoaeei,
1997; A.I.Aeanyoa?ee oa ii., 1998). Aei aeieniiai /ano iieiie/aii
cia/iee aeinaiae o aeiaaiinoeoei, ?ic?iaeaii iiai iaoiaee eieoaaiiy, yei
iineoaeeee iniiaith aeey eiina?aaoeaii-ae/ieoaaeueii? oa?aii? AI, a
iia?aoeaii ao?o/aiiy aeeiiothoueny eeoa ca noai?eie iieacaiiyie
C.Niederau, K.Lhthen, 1995; A.N.Naaaeueaa e ae?., 1996; A.A.Oaeeiia e
ae?., 1997). Aea, iacaaaeath/e ia oea, iiooi aiaaiaii ia iiaea
i?iaiicoaaoe eiiaoeue eieoaaiiy oai?iai c oei?th iaoieiai?th, oiio ui
i?ioean aiaeaoaa?oueny ianoieueee oaeaeei, ui iaeaea o ia?oi aiaeeie
oaca iaa?yeo iiaeoeoieiai? caeice (IC) iiaea ia?aeoe o oaco iae?ico
(N.A.Oaeeiia e ae?., 1990; A.A.Iaiei, A.H.Iena?aaneee, 1993;
TH.A.Hanoa?aiei e ae?., 1994; A.E.Eoiaeueoeia, 1998; P.G.Lankisch,
P.A.Banks, 1998). A ineieueee eaoaeueiinoue i?e aeano?oeoeaieo oi?iao AI
o aeanyoee ?acia ia?aaeuo? caaaeueio eaoaeueiinoue, oi iaaieueii
iai?ioo?oueny iaeei aeniiaie — iio?iaii ?aii? aia?aieia eiina?aaoeaia
eieoaaiiy, ui aeicaiey? coieieoe i?ioean oa iiia?aaeeoe ia?aoiae
iaa?yeiai? oi?ie o aeano?oeoeaiee i?ioean. O eiiieaeni eieoaaeueieo
caoiaeia canoiniao?oueny aaeeea eieueeinoue eiea?nueeeo caniaia, ui
iathoue ?icii iaoaiicie aei? i neeaaeathoue iniiao no/anieo i?eioeeiia
eiina?aaoeaiiai eieoaaiiy AI (A.A.Iieeoaineiaia e ae?., 1994; A.E.Oeeei,
A.E.Einoth/aiei, 1994; TH.A.Eaaiia, A.A.ssniaoeia, 1998; I.A.Eaaiia e
ae?., 1998). Iieacaiiy aeey aaaaoueio c ieo aenia?eiaioaeueii
iaa?oioiaaii i eeiii/ii aei?aaaeaii. Aoaeoeaiinoue iioeo anoaiiaeaii
iaaeinoaoiuei. Aeey ei?aeoei? ii?ooaiue iie?ioee?eoeyoei?
aeei?enoiaothoueny, ye i?aaeei, iecueeiiieaeoey?ii aeaeno?aie oa
oiciieiai/ii nieueiai ?ic/eie, yei, ye aeia?a aiaeiii, ia ?
ia?aiinieeaie eenith oa ia aeeiiothoue aeeoaeueii? ooieoei? e?iai.
Canoinoaaiiy c oei?th iaoith iioeo i?aia?aoia aaco?oueny ia ?acoeueoaoao
ainoieiai/ieo aeineiaeaeaiue oa ia?eoa?e/ii? iie?ioee?eoeyoei?, a ia ia
ciiiao e?iaino?oio o naiie IC. Aeaii i?i aaiiaeeiaii/ii oa noaeeiii
ii?ooaiiy o caeici iiae /an AI io?eiaii, ia?aaaaeii, ic aeei?enoaiiyi
ii?oieiai/ieo iaoiaeee, a o eeiiioei — iai?yieie iaoiaeaie. Aeey
ii?iaeicaoei? eeniaaiai aaeaino aaeeaathoue eeniueioa?aiith. O
eioa?aoo?i c’yaeythoueny iiaiaeiieaiiy i?i iiaeeeainoue oiene/ii? aei?
aiia?ieni? o ca’yceo c ooai?aiiyi aieueieo ?aaeeeaeia eenith, a oaeiae
aacieiino?eeoi?iith ?aaeoei?th ia eenaiue noaeei iie?ioee?eoeyoi?iiai
?onea. Ie ia cono?iee aeineiaeaeaiue, ui i?enay/aii aea/aiith aei?
eiea?nueeeo caniaia ia iaiii eenith o IC i?e AI, a oaeiae, aianeiaeie
oeueiai, i ?aeiiaiaeaoeie uiaei ?o canoinoaaiiy c iaoith ei?aeoei?
aiiieni? caeice. Aiaenooii aeaii i?i ii?iaiyeueio aoaeoeaiinoue
aaeeaaiiy aioeieneaeaioia iiae /an eieoaaiiy ?icieo oi?i AI. Ioeiiea
?acoeueoaoia ?o canoinoaaiiy aa?ith? aiae noaaeueii? aei noiiiaii?.
Ioaiiy IC ye /eiiee, a aaiiaeeiaii/ii oa noaeeiii ii?ooaiiy, c?ooaiiy
eeniaaiai iaiiio o naiie caeici oa i?ioeania aieueii?aaeeeaeueiiai
ieeneaiiy eiiiaeia, ye aaaeeeai iaoiaaiaoe/ii eaiee AI, i?e aea/aiii
aei? i?aia?aoia aea/aeenue, ye i?aaeei, icieueiaaii, iacaaaeath/e ia ?o
i?e/eiii-ianeiaeeiai aca?iiaiaeiineie. Io /iio i?e iayaiinoi cia/ii?
eieueeinoi aaeeaa?ieo iiae /an AI eiea?nueeeo caniaia, ?aoeiiiaeueiiai
aeai?o ia ei?enoue oeo /e iioeo iaia?. Oaeei /eiii, i?iaeaia eieoaaiiy
AI eeoa?oueny neeaaeiith oa iaaeinoaoiuei ae?ioaiith. Oniio caeaaeaoeia
aiae oiai, ye oaeaeei a a?naiaei oi?o?aia c’yaeyoueny i?aia?aoe, ui
aeicaieyoeiooue aeineoue aoaeoeaii aeeiioaaoe ei?aeoeith oaeeo iiaeo
eaiie iaoiaaiaco AI, ye oeaieiiee e?iaino?oi, iaiii eenith,
?aaeoeaiinoue noaeei iie?ioee?eoeyoi?iiai ?onea IC, i?ioeane
aieueii?aaeeeaeueiiai ieeneaiiy eiiiaeia, ieenethaaeueii-aiaeiiaiee
iioaioeiae. Naiae/aiue i?i aieea o?aioaeo (iaioieneoieiio) oa
oiio?eacieiio ia oeaieiiee e?iaino?oi, iai?oao eenith (?I2),
?aaeoeaiinoue noaeei o IC iiae /an AI ye o aenia?eiaioi, oae i a
eeiieoei iaie ia ciaeaeaii. Aeioeieueiinoue aaeeaaiiy o?aioaeo
a?oioo?oueny ia iiceoeaiiio aieeai eiai ia ?aieiai/ii aeanoeainoi e?iai,
ia?eoa?e/io iie?ioee?eoeyoeith, iioiii i?ioeane, oiio?eacieiio- ia
aeayei caaaeueiieeiii/ii oa aiioiii/ii iieacieee i, iiaeeeai, ia
aioeieneaeaioieo aeanoeainoyo inoaiiueiai, yei aeyaeaii a oiiaao iioi?
iaoieiai?.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

?iaioo aeeiiaii caiaeii c caaaeueiei ieaiii iaoeiai-aeineiaeieo ?iaio
E?einueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ii. N.I.Aai?ai?anueeiai
ca i?iaeaiith 21.03 «Haaiaeeeaaeia oi?o?aiy». Aiia ? o?aaiaioii
eiiieaenii? ieaiiai? oaie eaoaae?e oi?o?ai/ieo oai?ia OII c eo?nii
oaeoeueoaonueei? oi?o?ai? «Oneeaaeiaiiy aino?eo oi?o?ai/ieo
caoai?thaaiue oa o?aai i?aaiia /a?aaii? ii?iaeieie». Aea?aeaaiee
?a?no?aoeieiee iiia? 01.96.OI.14108, oeo? oaie 1.111.

Iaoa oa caaaeaiiy aeineiaeaeaiiy

Iaoith oeueiai aeineiaeaeaiiy ? aenia?eiaioaeueia i eeiii/ia
iaa?oiooaaiiy canoinoaaiiy o?aioaeo oa oiio?eacieiio ye caniaia
iaoiaaiaoe/ii? oa?aii? AI.

O i?ioeani aeineiaeaeaiiy ae?iooaaeeny ianooiii caaaeaiiy:

1. Ha aenia?eiaioaeueiie iiaeaei AI aea/eoe aeeiaiieo ciii oeaieiiiai
e?iaino?oio, ?I2 oa ?aaeoeaiinoi noaeei o IC.

2. Ha oeie naiie iiaeaei aino?iai aenia?eiaioaeueiiai iaie?aaoeoo (AAI)
aeineiaeeoe aiino i?iaeoeoia ia?aeeniiai ieeneaiiy eiiiaeia (IIE) o
ne?iaaooei e?iai oa aeoeaiinoue aeaaiae?iaaiac (NAeA, EAeA, ?-AOAeA,
A-6-OAeA) o iaeo?ioieueieo a?aioeioeeoao e?iai.

3. Aea/eoe aeith o?aioaeo oa oiio?eacieiio ia oeaieiiee e?iaino?oi, ?I2,
?aaeoeaiinoue noaeei o IC, aiino i?iaeoeoia IIE oa aeoeaiinoue
aeaaiae?iaaiac iiae /an AAI.

4. Aea/eoe aeeiaiieo ciii aiinoo i?iaeoeoia IIE, aeoeaiinoi
aeaaiae?iaaiac, ?yaeo aiioiii/ieo iieacieeia e?iai oai?eo ia AI o
i?ioeani eieoaaiiy o?aaeeoeieieie aacenieie caniaaie.

5. O oai?eo ia AI, yeei ii?yae ic aaceniith oa?aii?th i?ecia/aee o?aioae
oa oiio?eacieii, aea/eoe noai i?ioeania IIE, aeoeaiinoue aeaaiae?iaaiac,
aeeiaiieo eeiii/ieo oa eaai?aoi?ieo iieacieeia. I?iaanoe aiaeic
aoaeoeaiinoi niieo/aiiai aaeeaaiiy o?aioaeo oa oiio?eacieiio iiae /an
eieoaaiiy oai?eo ia AI.

Haoeiaa iiaecia io?eiaieo ?acoeueoaoia

Ha iiaeaei AAI aia?oa i?iaaaeaii eiiieaenio ioeiieo ciii oeaieiiiai
e?iaino?oio o IC ca iaoiaeii aiaeiaaiai eei?aino, ?I2 o oeaieiao caeice
ca iiey?ia?aoi/iei iaoiaeii oa ?aaeoeaiinoi noaeei iie?ioee?eoeyoi?iiai
?onea IC. Ia?aeaeueii ia oie naiie iiaeaei AI aea/eee aeoeaiinoue
aeaaiae?iaaiac a iaeo?ioieueieo a?aioeioeeoao e?iai oa i?ioeane
aieueii?aaeeeaeueiiai ieeneaiiy eiiiaeia.

Anoaiiaeaii, ui a i?ioeani ?icaeoeo AAI o oeaieii caeice iaaea? ?I2,
ciaioo?oueny oeaieiiee e?iaino?oi, ii?ooo?oueny ?aaeoeaiinoue noaeei
iie?ioee?eoeyoi?iiai ?onea caeice.

Iieacaii, ui AAI noi?iaiaeaeo?oueny aeoeaaoei?th i?ioeania IIE, ciiiaie
aeoeaiinoi NAeA, EAeA, ?-AOAeA, A-6-OAeA o iaeo?ioieueieo a?aioeioeeoao
e?iai, ?icaeoeii eiiiainiaaiiai iaoaaiei/iiai aoeeaeico.

Aeyaeaii ?iceaaeiaiiy iio?ai?aaiiiai e?iaino?oio, iaiiio eenith,
?aaeoeaiinoi noaeei iie?ioee?eoeyoi?iiai ?onea o IC, c iaeii/aniei
iiaeneeaiiyi i?ioeania aieueii?aaeeeaeueiiai ieeneaiiy eiiiaeia oa
aeoeaiinoi ieenethaaeueieo oa?iaioia, ? aaaeeeaeie eaieaie iaoiaaiaco
AI.

Aenia?eiaioaeueii iaa?oioiaaii canoinoaaiiy o?aioaeo (iaioieneoieiio) oa
oiio?eacieiio ye caniaia iaoiaaiaoe/ii? oa?aii? AI.

Aia?oa anoaiiaeaii, ui o?aioae oa oiio?eacieii ia onoaathoue ii?ooaiiy
oeaieiiiai e?iaino?oio o IC i?e AAI, aaeueiothoue ?icaeoie aiiieni?
caeice aianeiaeie ciaioaiiy niiaeeaaiiy eenith oa ii?iaeicothoue
?aaeoeaiinoue noaeei iie?ioee?eoeyoi?iiai ?onea IC.

Aia?oa i?iaaaeaii eeiii/io ioeiieo niieo/aiiai aaeeaaiiy o?aioaeo oa
oiio?ecieiio i?e eieoaaiii oai?eo ia iaa?yeiao oi?io AI.

I?aeoe/ia cia/aiiy io?eiaieo ?acoeueoaoia

?acoeueoaoe aenia?eiaioaeueieo oa eeiii/ieo aeineiaeaeaiue aeicaieythoue
?aeiiaiaeoaaoe o?aioae oa oiio?eacieii ye caniae iaoiaaiaoe/ii? oa?aii?
oai?eo ia AI. Niieo/aia ?o aaeeaaiiy i?e eieoaaiii oai?eo ia iaa?yeiaee
iaie?aaoeo ni?ey? iieiioaiith oa/i? caoai?thaaiiy, nei?i/o? oa?iiie
ii?iaeicaoei? eeiiiei-ooieoeiiiaeueieo i?iyaia oai?iae, eaai?aoi?ieo
iieacieeia, c?ooaiue o aeoeaiinoi ieenethaaeueieo oa?iaioia oa
i?iaeoeoia IIE. Oea ni?ey? aieueo ?aiiueiio, o ii?iaiyiii ic
o?aaeeoeieiith aaceniith oa?aii?th, iaeoaeaiith oai?eo oa nei?i/o? /an
?o ia?aaoaaiiy o noaoeiiia?i.

Aeeth/aiiy o?aioaeo oa oiio?eacieiio aei eiiieaenii? eiina?aaoeaii?
oa?aii? oai?eo ia AI ia?aoeiaeaea? i?ia?anoaaiith caoai?thaaiiy oa
ia?aoiaeo iaa?yeiai? oi?ie AI o aeano?oeoeaii.

Io?eiaii a ?acoeueoaoi aeineiaeaeaiue aeaii aeicaieythoue ?aeiiaiaeoaaoe
o?aioae oa oiio?eacieii aeey oe?ieiai aeei?enoaiiy ?o o oi?o?ai/iie
i?aeoeoei aeey eieoaaiiy oai?eo ia AI.

?aeiiaiaeiaaii iaie aeey eieoaaiiy oai?eo ia iaa?yeiao oi?io AI
i?aia?aoe o?aioae oa oiio?eacieii ai?iaaaeaeaii o oi?o?ai/ieo
aiaeaeieaiiyo: ?anioaeieainueei? eeiii/ii? eiea?ii ii. I.A.Naiaoei, i.
Niioa?iiieue; Oe?E Naenueeiai ?aeiio, i. Naee; Aiaeaeieainueei?
eeiii/ii? eiea?ii noaioei? Niioa?iiieue; 6-i? iinueei? eeiii/ii? eiea?ii
oaeaeei? aeiiiiiae i. Niioa?iiiey; Oe?E *a?aiiiaaa?aeienueeiai ?aeiio,
iio. *a?aiiiaaa?aeienuee; Oe?E Niioa?iiieuenueeiai ?aeiio, i.
Niioa?iiieue.

Io?eiaii ?acoeueoaoe aenia?eiaioaeueieo oa eeiii/ieo aeineiaeaeaiue
aeei?enoaii a iaa/aeueiio i?ioeani ia oi?o?ai/ieo eaoaae?ao E?einueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ii. N.I.Aai?ai?anueeiai.

Iniaenoee aeeaae caeiaoaa/a

Aaoi? naiinoieii aeeiiaa aenia?eiaioaeueiee oa eeiii/iee ?icaeiee
?iaioe. I?iaia aenia?eiaio ia 78 niaaeao, a eeiieoei ianoaaeea oa
i?ieieoaaa 46 oai?eo ia AI. Ia?iaea ?acoeueoaoe aeineiaeaeaiue, c?iaea
?o aiaeic, i?iaiaeicoaaa eioa?aoo?ii aeaea?aea, cai?iiiioaaa
eiino?oeoeith aeaeo?iaeia oa niinia ?o oienaoei? aeey ?iaioe ia IC.
Oaoii/ii aeaiaioe eiino?oeoei? aeaeo?iaeia aeeiiaii ?acii ic
eaiaeeaeaoii iaaee/ieo iaoe I.Ae.Naiaaiiei oa iaaino?aioii
A.I.Nei?iiiei. ?acii io?eiaii iinaiae/aiiy i?i ?aoeiiiaeicaoi?nueei
i?iiiceoei?. Ineieueee a ?iaioi aeei?enoaii ainoieiai/ii,
aeaeo?iiiiiie?ineiii/ii oa aiioiii/ii iaoiaee, ui aeiaaathoue
niaoeiaeueii? iiaeaioiaee, oi aeineiaeaeaiiy ic aeei?enoaiiyi oeeo
iaoiaeee i?iaaaeaii ?acii c i?ioani?aie A.E.Caai?oeueei, I.I.Eieaaniiei,
A.TH.Aaeeoeueeei oa eaiaeeaeaoii aiieiai/ieo iaoe A.A.Eicaeiaith. ?acii
c ieie iioaeieiaaii ?acoeueoaoe aeineiaeaeaiue.

Ai?iaaoeiy ?acoeueoaoia aeena?oaoei?

?acoeueoaoe aeineiaeaeaiue aeiiiaiaeaeeny ia Ae?oaie iaoeiai-i?aeoe/iie
eiioa?aioei? «Aeooaeueii i?iaeaie aenia?eiaioaeueii? iaaeeoeeie.- 9-10
o?aaiy 1998 ?.- Ee?a; ia 2 Iiaeia?iaeiiio iaaee/iiio eiia?ani nooaeaioia
i iieiaeeo a/aieo.- 6-8 o?aaiy 1998.- Oa?iiiieue; ia ?anioaeieainueeie
iaoeiai-i?aeoe/iie eiioa?aioei? «Aeinyaiaiiy oa iaae?ioaii ieoaiiy
aano?iaioa?ieiai?», 7-8 eaioiy 1998 ?.- Oa?eia; ia eiioa?aioei?,
i?enay/aiie 75-?i//th caneoaeaiiai aeiy/a iaoee, i?ioani?a E.Ae.
Oineiia, 1997.- Niioi?iiieue — ?aiaoi?iy.

Ioaeieaoei?. Ca iaoa?iaeaie aeena?oaoei? iaae?oeiaaii 13 ?iaio, c ieo 7-
o aeaeaiiyo, ui eioeaiciaaii AAE Oe?a?ie (4 iiii oa 3 o niiaaaoi?noai),
5- o iaoa?iaeao iaoeiaeo eiioa?aioeie, 1- o oacao aeiiiaiaeae, c?iaeaii
2 ?aoeiiiaeicaoi?nueei i?iiiceoei?.

Ia’?i oa no?oeoo?a aeena?oaoei?

Aeena?oaoeieio ?iaioo neeaaeathoue anooi, ?icaeiee: iaeyae eioa?aoo?e,
iaoa?iaee oa iaoiaee aeineiaeaeaiiy, ?acoeueoaoe aeanieo aeineiaeaeaiue
(4 iiae?icaeiee), aiaeic oa ocaaaeueiaiiy ?acoeueoaoia aeineiaeaeaiue,
aeniiaee oa nienie aeei?enoaieo eioa?aoo?ieo aeaea?ae. Aeena?oaoeeth
aeeeaaeaii ia 143 noi?iieao ae?oeiaaiiai oaenoo, ui iinoyoue 19
oaaeeoeue, 22 iaethiea (c yeeo 19 iie?ioioia?aoie). Nienie eioa?aoo?e
iinoeoue 259 aeaea?ae.

Ciino ?iaioe

Iaoa?iaee i iaoiaee aeineiaeaeaiiy

Aenia?eiaioaeueiee ?icaeie ?iaioe aeeiiaiee ia 78 aacii?iaeieo niaaeao
ianith 10-18 ea, yeeo oo?eioaaee o aiaa?ith c o?aooaaiiyi iaiaoiaeieo
ea?aioeiieo caoiaeia. Eeiii/iee ?icaeie iinoeoue 46 oai?eo ia AI.

Oaa?ei aaiaeeee aei ia?eico oeyoii aioo?ioiuei/a?aaeiiiai aaaaeaiiy
aoaiiiae-iao?ith 30 ia/ea oa oiiiaioaei-iao?ith 20 ia/ea. AAI aeeeeeaee
?ao?ia?aaeiei aioo?ioiueii?ioieiaei aaaaeaiiyi aooiaeia/i ia’?iii 0,1
aai 0,3 ie ia ea iane oaa?eie iiae oeneii 250 ii aiaeiiai noiaaa. Aei
aiaeoai?aiiy AI ?a?no?oaaee oiiiai (aeoiaeii) cia/aiiy oeaieiiiai
e?iaino?oio, ?aaeoeaiinoi noaeei, ?I2 o IC ca aeiiiiiaith aieue/aoeo
aeaeo?iaeia iaoi? eiino?oeoei?, a?oa?iaeueiee oene o noaaiiaie a?oa?i?
oa /anoioo aeeoaiiy. A?aee e?ia c iaoith aeineiaeaeaiiy i?iaeoeoia IIE,
eeneioii-eoaeiiai noaio (EIN), a ia i?aaeiaoiiio neei ?iaeee iacee e?iai
aeey ainoioiii/iiai aea/aiiy aeoeaiinoi aeaaiae?iaaiac. Iiney 30 oa oa
eiaeii? aiaeeie i?ioyaii 8 aiaeei iiney iiaeoeoei? AI ?a?no?oaaee
aeacaii aeua iieacieee, a ia aeayeeo aiae?iceao /ano (4-6 aai 6-8 a)
a?aee e?ia oa ?iaeee iacee aeey aiioiii/ieo oa oeeoioiii/ieo
aeineiaeaeaiue. Caaeaaei oaa?ei ia niinoa?iaaeiny. Iiney caeii/aiiy
aenia?eiaioo niaae aeaiaeeee c aeineiaeo iiaio?yiith aiaiei?th. C iaoith
aeyaeaiiy ii?oieiai/ieo ii?ooaiue o?aaiaioe oeaieie IC a?aee aeey
ainoieiai/ieo aeineiaeaeaiue. O na?iyo aeineiaeia c aea/aiiy aei?
i?aia?aoia o?aioae o aeici 10 i 20 ia/ea oa oiio?eacieii- 25 ia/ea
aaiaeeee aioo?ioiueiaaiii /a?ac 15 oa iiney aiaeoai?aiiy AI.
Iineiaeiaiinoue aeii?thaaiue ia?aiao?ia, ui aeineiaeaeoaaeeny, aoea
oaeith ae, ye o aenia?eiaioao c AI aac aaeeaaiiy eiea?nueeeo caniaia.

Eieaeueiee oeaieiiee e?iaino?oi o IC aecia/aee ca iaoiaeii aiaeiaaiai
eei?aino (E.O.Aeai/aiei, 1976; 1981; A.A.Iaea?ia e ae?., 1980), ?I2 o
oeaieiao caeice ca iiey?ia?aoi/iei iaoiaeii (A.A.Aa?acianeee, 1975;
A.A.Eiaaeaiei e ae?., 1975), ?aaeoeaiinoue noaeei ioeiithaaee ca
eiaoioei?ioii ?aaeoeaiinoi ia iiaaeyoeith 7% noiioi NI2 c iiaio?yi.
OAE-aeoeaii i?iaeoeoe IIE a ne?iaaooei e?iai i?e AAI aea/aee ca iaoiaeii
(T.Asckawa et all., 1980), aioeieneaeaioio aeoeaiinoue (AIA) ca iaoiaeii
A.E.Naiaiia, A.I.ss?io (1985), iieaeoee na?aaeiuei? iane (INI) ca
iaoiaeii (H.E.Aaa?eyeyi, A.E.Eeiaoiaa, 1984), caaaeueii eiiiaee ca
eieuei?iaith ?aaeoei?th ic noeueoioinoiaaieeiiiaei ?aaeoeaii (A.A.Eiea,
A.N.Eaiuoieeia, 1982). Aeoeaiinoue aeaaiae?iaaiac o iaeo?ioieueieo
a?aioeioeeoao e?iai aeineiaeaeoaaee ca caaaeueiii?eeiyoeie iaoiaeeeaie
(Y.Ie?n, 1962; I.A.Ai?eniaa e ae?., 1975; 1983). Aeey ioeiiee aeoeaiinoi
oa?iaioia iiae?aoiaoaaee na?aaeiie oeeoioiii/iee iieaciee G.Astaldi,
L.Verga, 1957). EEN o aaiiciie e?iai ioeiithaaee ca iie?iiaoiaeii
(O.Siggard-Anderson et all., 1960) ic aeei?enoaiiyi iiiia?ai
(A.O.Aiaiyaeaineee e ae?., 1971; S.Havas, I.Peteri, 1974). Ainoieiai/ii
oa aeaeo?iiii-iie?ineiii/ii aeineiaeaeaiiy oeaieie IC i?iaiaeeee ca
caaaeueiii?eeiyoeie iaoiaeeeaie.

Ianoaaeaii 46 oai?eo aieii aiae 49 aei 52 ?ieia, na?aae yeeo 26
/ieiaieia oa 20 aeiiie, c iaa?yeiaith oi?iith AI na?aaeiuei? aaaeeinoi.
Aeiaaiic aoei iinoaaeaii ia iiaenoaai eeiii/ieo i?iyaia caoai?thaaiiy,
eaai?aoi?ieo aeineiaeaeaiue oa iino?oiaioaeueieo iaoiaeia. O anio oai?eo
aoei i?iaaaeaii oeueo?acaoeiaa aeineiaeaeaiiy
aaiaoiiaie?aaoiaeoiaeaiaeueii? ciie, a o 10 oai?eo- eaia?ineiiiy.
Aeei?enoaiee iaie a aenia?eiaioi neeaaeiee iaoiaee/iee eiiieaen ia
iiaeia aoei iiaiinoth ia?aianoe o eeiiieo, oiio ui aeii?thaaiiy
oeaieiiiai e?iaino?oio, ?I2, ?aaeoeaiinoi noaeei o IC iiaeeeai oieueee a
oiiaao iia?aoeaieo ao?o/aiue ia caeici oa aeene?aoii. O ca’yceo c oeei,
aeey ioeiiee aoaeoeaiinoi o?aioaeo oa oiio?eacieiio i?e eieoaaiii oai?eo
ia AI, a oiiaao eeiiiee ie canoinoaaee iaoiaee aea/aiiy i?iaeoeoia IIE
oa aeineiaeaeaiiy aeoeaiinoi aeaaiae?iaaiac. Oaea iiaeeeainoue
iaoiiaeaia oei, ui a aenia?eiaioi aoea anoaiiaeaia oinia
i?e/eiii-ianeiaeeiaa caeaaeiinoue iiae ciiiaie aeacaieo iieacieeia ye o
i?ioeani ?icaeoeo AI, oae i i?e aaeeaaiii i?e oeeo oiiaao o?aioaeo oa
oiio?eacieiio. Ia?aeiii i?iaeoeoe IIE- aei?iiai eaoiie oa aei?iiai
eii’thaaoe aecia/aee ca iaoiaeeeith (C.Ieaoea? e ae?., 1970) o
iiaeeoieaoei? (A.A.Aaa?eeia, I.E.Ieoei?oaeiay, 1983), aoi?eiii
i?iaeoeoe- iaeiiiaee aeiaeueaeaaiae (IAeA) ca iaoiaeii (H.Ohakawa et
all., 1979). Aeoeaiinoue aeaaiae?iaaiac o iaeo?ioieueieo a?aioeioeeoao
e?iai ca oeie ae iaoiaeaie, ui i a aenia?eiaioi. Aiino caaaeueiiai
aiei?oaiio, aeoeaiinoue ?-aiieace, eieueeinoue eaeeioeeoia aecia/aee
caaaeueiii?eeiyoeie iaoiaeaie (A.A.Eiea, A.N.Eaiuoieeia, 1982; A.A.Eino,
1975). Aeacaii iieacieee aea/aee i?e iaaeoiaeaeaiii oai?eo aei
noaoeiiia?o, ia 3, 5, 7 aeiao eieoaaiiy oa ia?aae aeieneith. I?iaaaeaia
eiiieaenia ianoaaeaiiy aeicaieeei o 98% oai?eo aeyaeoe aoiieiai/ii
oaeoi?e, ui ni?eyee ?icaeoeo AI. O aiaeiiaiaeiinoi aei caaaeaiue
aeineiaeaeaiiy oai?eo aoei iiaeieaii ia 2 a?oie. Ia?oo a?oio neeaee 25
oai?eo, yeei i?iaiaeeee aacenio oa?aiith. Eiiieaen eieoaaeueieo caoiaeia
aoei ni?yiiaaii ia: onoiaiiy aieth, caaacia/aiiy ooieoeiiiaeueiiai
niieith IC, aeaciioieneeaoeith, ei?aeoeith aieaii/ieo ii?ooaiue oa
?iceaaeiaiue iie?ioee?eoeyoei?, noaaieicaoeith aiineioaoe/ieo i?ioeania
o iaie?aaoioeeoao, aiaeii aiaeiiaeaiiy aia?aaoe/ieo cao?ao oa
i?ioieaeoeeo aiieieo oneeaaeiaiue. Oai?ei ae?oai? a?oie (21 ethaeeia)
e?ii aacenii? oa?aii? i?ecia/aee o?aioae oa oiio?eacieii. Eiea?nueei
caniae aaeeaaee ca ianooiiith noaiith. C 1-ai ii 5-e aeaiue o?aioae
aaiaeeee aioo?ioiueiaaiii e?aiaeueii ii 100 ia aeai/i ia aeiao, a c
oinoiai aeiy ii 100 ia 1 ?ac ia aeiao. Oiio?eacieii c 1-ai ii 5-e aeaiue
aaiaeeee aioo?ioiueiaaiii e?aiaeueii ii 100 ia 1 ?ac ia aeiao oa
aioo?ioiueii’yciai ii 50 ia 3 ?ace ia aeiao, a c 6-ai aeiy ii 50 ia
aioo?ioiueii’yciai 3 ?ace ia aeiao. ?acoeueoaoe aenia?eiaioaeueieo oa
eeiii/ieo aeineiaeaeaiue iiaeaeaaaee noaoenoe/iie ia?iaoei ca
iaoiaeeeith ?aoaeueii iienaiith (E.A.Ieaei, 1960). I?e oeueiio
aeei?enoiaoaaee ye aaniethoii aaee/eie, oae i aiaeiinii /enea iai/iinoi.
Noaoenoe/ii ai?iaiaeieie i?eeiaee ciiie i?e ?<0,05. ?acoeueoaoe aeanieo aeineiaeaeaiue Io?eiaii a aenia?eiaioi aeaii naiae/aoue i?i oa, ui i?e iaa?yeiaie oi?ii AI aaea /a?ac 1 aiaeeio niinoa?iaa?oueny ciaioaiiy oeaieiiiai e?iaino?oio (-12,7+5,3%, P<0,02), iaaeiiiy ?I2 (-14+5,8%, P<0,05), caieueoaiiy eiaoioei?ioo ?aaeoeaiinoi noaeei (+20,2+5,2%, P<0,001) o IC. Haaeaei, i?ioyaii 2-3-4 aiaeei aiae ii/aoeo aaaaeaiiy iiae?acithaa/a, ciiie e?iaino?oio oa ?aaeoeaiinoi noaeei aoee noaoenoe/ii iaai?iaiaeieie, a ?I2 o oeaieiao caeice cieceeiny (-26,0+5,9 - 41,0+8,6%, P<0,001). Haecia/iioi c?ooaiiy aea/a?ieo iieacieeia aeyaeyeeny i 5-8 aiaeeii c iiiaioo iiaeoeoei? AI. O IC ca?a?no?iaaii cieaeaiiy e?iaino?oio (-13,6+5,4 - 22,8+5,7%, P<0,05), iaaeiiiy ?I2 (-42,0+8,5 - 49,0+9,3, P<0,001) oa ciaioaiiy eiaoioei?ioo ?aaeoeaiinoi noaeei -7,0+3,3 - 15,0+4,7%, P<0,05). I?e oeueiio a?oa?iaeueiee oene cieceany ia 8-9% (P<0,05), a /anoioa aeeoaiiy nooo?ai ia ciiieeany. I?e aaii?aai/iie oi?ii AAI oa?aeoa? aeyaeaieo c?ooaiue i?eioeeiiai nooo?ai ia aiae?iciyany aiae oeo, yei aoei aeyaeaii i?e iaa?yeiaiio iaie?aaoeoi. Anoaiiaeaii ai?iaiaeia cieaeaiiy e?iaino?oio (-16,0+6,5 - 20,0+4,2%, P<0,05), ciaioaiiy ?I2 (-14,0+4,2 - 54,4+5,1%, P<0,001) oa oaciai ciiie ?aaeoeaiinoi noaeei (/a?ac 30 oa aaee/eia eiaoioei?ioo ?aaeoeaiinoi c?inoaea, iioii ciiithaaeany iaai?iaiaeii, a i 5-8 aiaeeie ciaiooaaeany). Niinoa?iaaeeny aieueo nooo?ai c?ooaiiy a?oa?eaeueiiai oeneo oa aeeoaiiy. Ii?iaithth/e aeyaeaii ciiie e?iaino?oio a IC ic ?aiioa io?eiaieie aeaieie i?i ii?ooaiiy iie?ioee?eoeyoei? i?e AAI (A.E.Oeeei, A.I.Aeaee?ei, 1982; E.Ae.Iao?ooiaa, 1989; T.Kerner et all., 1996), neiae aeacaoe, ui ciaioaiiy e?iaino?oio o IC i?ioyaii ia?oeo 30 oa oa 1-? aiaeeie ?icaeoeo AI iaoiiaeaii aacieiino?eeoei?th a?oa?iiey?iiai naaiaioo iie?iaaneoey?iiai ?onea IC, a iioii ?icoe?aiiyi noaeei aaiiciiai aiaeaeieo, iiaeaeuaiiyi a'yceinoi oa noacii e?iai. Ona oea o eiioeaaiio iiaenoieo i?ecaiaeeoue aei ii?ooaiiy ia?ooci? oeaiei IC. Cia/ia iaaeiiiy ?I2 o IC iaoiiaeaii ia oieueee ciaioaiiyi e?iaino?oio, aea i iiaeaeuaiiyi niiaeeaaiiy I2, oiio ui cieaeaiiy ?I2 niinoa?iaaeiny i a oeo aeineiaeao, a yeeo e?iaino?oi ia ciiithaaany aai ia aeayeeo aiae?iceao /ano aeaeieueea c?inoaa. Nooo?aa cieaeaiiy ?I2 o oeaieiao IC (ia 49,0-54,4%) neiae ?icaeyaeaoe ye iani?eyoeeaee /eiiee, oiio ui ciaioaiiy ?I2 o oeaieiao ieae/a e?eoe/iiai ?iaith noai?th? aaeeeo iaaaciaeo aeieiaiiy aeeoaeueieo oa?iaioia eeioei oa aeiaaeiiiy aieiaiiai oeyoo caieueiaiiy aia?ai? (A.A.Aa?acianeee, 1975). C?inoaiiy eiaoioei?ioo ?aaeoeaiinoi noaeei nii/aoeo ?icaeoeo AI aeaco? ia aaciaeeeyoaoi?io ?aaeoeith noaeei iie?iaaneoey?iiai ?onea IC aeeoaiiy noiiooth NI2 c iiaio?yi. Oea naiae/eoue i?i oa, ui ia oeueiio aiae?iceo /ano ?aaeoeaiinoue noaeei caeice caa?aaeaia, oiio ui inoaiii aiae?aaaoaaee ia NI2 ?icoe?aiiyi. Iioa ea?oeia iaea iinoea c 5-i? aiaeeie ?icaeoeo AI, eiee ia iiaaeyoeith noiioi NI2 c iiaio?yi noaeeie IC aiae?aaaoaaee i?ioeeaaeiith ?aaeoei?th i, ye neiaenoai oeueiai, eiaoioei?io ?aaeoeaiinoi ciaioeany. Oea aeaco? ia cia/ia ii?ooaiiy ?o /ooeeainoi aei aaciaeieaoaoi?ieo aaaioia. Ciiie ?aaeoeaiinoi iie?inoaeei iathoue aaaeeeaa, a a aeayeeo aeiaaeeao ae?ioaeueia cia/aiiy o iaoiaaiaci ?yaeo caoai?thaaiue (N.A.Naeaciaa e ae?., 1985), o oiio /enei, iiaeeeai i i?e AI. Ciaioaiiy oeaieiiiai e?iaino?oio, cieaeaiiy ?I2 o oeaieii IC iaia'yceiai i?ecaiaeeoue aei aiiieni? caeice, iaeiie/aiiy iaaeiieeneaieo i?iaeoeoia iaiiio oa ?icaeoeo aoeeaeico. C?inoaiiy inoaiiueiai iiaea aooe aieiaiith i?e/eiith ciiie ?aaeoeaiinoi noaeei iaeaea aei ?o ?ao?aeoa?iinoi (F.R.Wells, 1971). C o?aooaaiiyi iaaaaeaiiai aeua, aeieeea iaiaoiaeiinoue o aea/aiii eeneioii-eoaeiiai noaio i?e AAI. ?acoeueoaoe aeineiaeaeaiue iieacaee, ui ?icaeoie iaa?yeiai? oi?ie AI noi?iaiaeaeo?oueny c?ooaiiyi ?aaeoei? o eeneee aie (?H aei iiaeoeoei? AI neeaea 7,28+0,01, a /a?ac 4 a oa 8 a iiney aiaeoai?aiiy AI 7,22+0,02 oa 7,18+0,02, P<0,001 aiaeiiaiaeii), caieueoaiiyi aeaoioeeoo eoa (-5,4+0,9 aei iiaeoeoei? AI oa -8,9+0,8 iaea/e /a?ac 8 a P<0,01), ciaioaiiyi noaiaea?oieo aiea?aiiaoia (c 19,0+0,9 aei 15,9+0,5 iaea/e, P<0,01). Hai?oaa aoaeaeeneioe ciiithaaeany iaai?iaiaeii. Ana oea aeaco? ia ?icaeoie, ia?aaaaeii, iaoaaiei/iiai aoeeaeico. I/aaeaeii, ui ciiie ia?aiao?ia aiiainoaco, ui aeineiaeaeothoueny, ia iiaee ia aieeiooe ia noai oeaieie IC, aeoeaiinoi ieenethaaeueieo oa?iaioia oa i?ioeania aieueii?aaeeeaeueiiai ieeneaiiy eiiiaeia. ?acoeueoaoe ainoieiai/ieo oa aeaeo?iiiiiie?ineiii/ieo aeineiaeaeaiue IC iieacaee, ui aaaaeaiiy o i?ioieiao nenoaio caeice aooiaeia/i ia'?iii 0,1 ie/ea i?ecaiaeeoue aei ?icaeoeo iaa?yeiai? oi?ie AI. I?e caieueoaiii ia'?io iiae?acieea (0,3 ie/ea) aeieea? aaii?aai/iee iaie?aaoeo, ui iinooiiai ia?aoiaeeoue o iae?ioe/iee. Ii nooi ia canoiniaaiie iaie iiaeaei AAI niinoa?iaathoueny oni oace ?icaeoeo iaoieiai/iiai i?ioeano- iaa?ye, aaii?aaiy oa iae?ic. Haeaieueo ?aiiiie ii?oieiai/ieie i?iyaaie AAI ? noaeeiii ii?ooaiiy, ui aeyaeythoueny i 6-8 aiaeeii iinooiiaei caieueoaiiyi iiaiie?ia'y noaeei iie?ioee?eoeyoi?iiai ?onea ic ieaciaoe/iei i?ino/oaaiiyi noiiee. Iiaeaei niinoa?iaathoueny eaeeioeeoa?ia iioieueo?aoeiy oa e?iaiaeeeae. Oei yaeua ?iceiai iiaeaeuaiiy i?iieeiinoi noiiie noaeei iaoiiaeaii ia?o ca ana ciiiaie c aieo aiaeioaeiaeueii? aenoeeee. Oaeei /eiii o i?ioeani ?icaeoeo AAI niinoa?iaathoueny ye ooieoeiiiaeueii ciiie i?aaiii? aaiiaeeiaiiee, ?aaeoeaiinoi noaeei oa ?I2, oae i ii?oieiai/ii ii?ooaiiy o iie?ioee?eoeyoi?iiio ?onei caeice. Nooiiiue iayaiinoi ?iceaaeiaiue ia?aiao?ia, ui aeineiaeaeothoueny, caeaaeeoue aiae oi?ie AI. Ioaiiy, aiiieniy IC, ciiie ?aaeoeaiinoi noaeei aeieeathoue ?aii oa a?athoue aeeeth/ii aaaeeeao ?ieue o iaoiaaiaci AI, oiio ui oaeoe/ii ? /eiieeaie, ui iiioeiththoue iaoaaiei/ii c?ooaiiy o eeioeiao IC, i aaaeooue aei ?o iioeiaeaeaiiy oa aooieico. Naia ioaiiy oa aiiieniy, ui eaea ca iath, i?ecaiaeyoue aei ooai?aiiy aieueieo ?aaeeeaeia eenith, a ?icea ciaioaiiy ?I2 o oeaieiao IC ii?ooo? aia?aaoe/iee iaiii o eeioeiao caeice. I/aaeaeii, ui ca aeiiiiiaith eieoaaeueieo caoiaeia, o oiio /enei eiea?nueeio caniaia, iiaeeeai i?eaaeueioaaoe oeae i?ioean. ?acoeueoaoe ie?aii? na?i? aenia?eiaioia naiae/aoue i?i oa, ui aeineiaeaeaii iaie i?aia?aoe ia iaee ii?iaeicoth/iai aieeao ia ii?ooaiiy e?iaino?oio o IC iiae /an AAI. Aioo?ioiueiaaiii ii'?eoei? o?aioaeo oa oiio?iacieiio /a?ac 15 oa iiney iiaeoeoei? AI ia caaaaeeee ciaioaiith e?iaino?oio o caeici, ui iaei iinoea o i?ioeani ?icaeoeo AI. Aieueo oiai, /a?ac 30 oa iiney aaaaeaiiy o?aioaeo a aeici 10 ia/ea niinoa?iaaeiny cieaeaiiy e?iaino?oio o IC (-16,5+4,2, P<0,002) o ii?iaiyiii c aeoiaeiei ?iaiai. I?ioyaii ianooiieo 4 aiaeei, iacaaaeath/e ia iaai?iaiaeiinoue na?aaeiio aaee/ei, oeaieiiee e?iaino?oi o caeici eeoaany ieae/a oiiiaeo cia/aiue oa iaaeeaeaany aei eiio?ieueieo aeineiaeia. Oaea naia caeiiiii?iinoue caa?iaaeany i iiaeaei, a ia ie?aieo aiae?iceao /ano- 5-a aiaeeia, e?iaino?oi aoa ieae/a, iiae o eiio?iei. Caieueoaiiy aeice o?aioaeo aaeai/i (20 ia/ea) aeeeeeaei i?ioyaii ia?oeo o?ueio aiaeei ua cia/iioa ciaioaiiy oeaieiiiai e?iaino?oio. I?e aaeeaaiii oiio?eacieiio (25 ia/ea) niinoa?iaaeiny cieaeaiiy e?iaino?oio (-18,1+4,9 - 30,8+4,7%, P<0,001) i?ioyaii onueiai ia?iiaeo aenia?eiaioo. Iiaeeeai, ui a oiiaao ?icaeoeo iaoieiai/iiai i?ioeano noaeeie IC aiae?aaaoaaee ia aaaaeaiiy o?aioaeo i oiio?eacieiio iaaaeaeaaoiith ?aaeoei?th, ui i?ecaaei aei ciaioaiiy e?iaino?oio o IC. Oaea yaeua oeieeii iiaeeeaa, oiio ui ?aaeoeiy noaeei iie?ioee?eoeyoi?iiai ?onea ia ?iciiiaiioii aieeae aecia/a?oueny ii/aoeiaei noaiii ?o iiiaaiiiai oiiono (N.A.Naeaciaa e ae?., 1985). ?acoeueoaoe aeineiaeia c aea/aiiy ?aaeoeaiinoi noaeei iieacaee, ui iiney 30 oa aiae aaeeaaiiy o?aioaeo o aeici 10 ia/ea iaei iinoea caieueoaiiy eiaoioei?ioo ?aaeoeaiinoi (+15,3+6,3%, P<0,05). Haeaieueo cia/ia iiaeaeuaiiy (+18,5+8,5 - 23,0+9,6%, P<0,05) noaeeiii? ?aaeoeaiinoi niinoa?iaaeiny i 5-6 aiaeeii aenia?eiaioo, eiee o eiio?ieueieo aeineiaeao ?aaeoeaiinoue noaeei cieaeoaaeany. I?e caieueoaiii aeice o?aioaeo (20 ia/ea) na?aaeii aaee/eie eiaoioei?ioo ?aaeoeaiinoi aoee noaoenoe/ii iaai?iaiaeieie, aea oaiaeaioeiy aei eiai caieueoaiiy caa?iaaeany. Aiaeiai/ia ?aaeoeiy niinoa?iaaeany i i?e aaaaeaiii oiio?eacieiio. Aeieea? a?aaeaiiy, ui ciiiaia o i?ioeani ?icaeoeo AAI ?aaeoeaiinoue noaeei o IC iiae /an aei? o?aioaeo oa oiio?eacieiio aiaeiiaeth?oueny. Iiaeoa /ei iiynieoe oie oaeo, ui o aiaeiiaiaeue ia iiaaeyoeith noiioi NI2 c iiaio?yi noaeeie iie?ioee?eoeyoi?iiai ?onea aiae?aaaoaaee aaciaeieaoaoi?iith ?aaeoei?th, i, ye ianeiaeie oeueiai, aaee/eia eiaoioei?ioo ?aaeoeaiinoi iiaeaeueeany. O oeueiio, iiaeeeai, iieyaa? iaeei c iiaeeeaeo iaoaiiciia aei? o?aioaeo oa oiio?eacieiio i?e AI. Aeineiaeaeaii i?aia?aoe iiiiaeththoue ii?ooaio a i?ioeani ?icaeoeo AI ?aaeoeaiinoue noaeei iie?ioee?eoeyoi?iiai ?onea IC, a oea aecia/a? aoaeoeaiinoue iioeo eieoaaeueieo caoiaeia, aaeaea ae aiie aiaeaoaathoueny ia cianii iioiio noaeeiiiio oiii. Oaeei /eiii, ia ia?aoeiaeaeath/e ciaioaiith e?iaino?oio o IC, o?aioae oa oiio?eacieii aenooiathoue ei?aeoi?aie noaeeiii? ?aaeoeaiinoi, aieeaath/e iiaeeeai ia iaiii eenith o IC. I?iaaaeaii iaie o oeueiio iai?yieo aeineiaeaeaiiy iieacaee, ui o?aioae oa oiio?eacieii a oiiaao AAI nooo?ai caaaaeeee iaaeiiith ?I2 o oeaieiao caeice, onoaath/e oaeei /eiii aiiienith eeioei IC. Cieaeaiiy ?I2 o oeaieiao caeice aoei o 2,5-3 ?ace iaioei o ii?iaiyiii c eiio?ieai. sseui o i?ioeani ?icaeoeo AI ?I2 cieaeoaaeany ia 14,0-49,0% (iaa?yeiaa oi?ia), oi iiney aaaaeaiiy o?aioaeo aiia ciaioeeany ia 5,3-19,5%. Oaeo ae aeith ia ?I2 a caeici iaa i oiio?eacieii. Iiceoeaiee aieea aeineiaeaeaieo i?aia?aoia ia ?I2 o IC iiae /an AI ia? i?eioeeiiaa cia/aiiy, oiio ui i?e iecueeeo cia/aiiyo ?I2 aia?aaoe/iee oa ieanoe/iee iaiiie eeioei cieaeothoueny, i?aaiaee eicothoueny, c'yaeythoueny ionoioe oa eiiiaeii a?aioee, aeieea? aeaaaia?aoeiy oa ?iciaae (A.A.Aa?acianeee, 1975). Noa? oeieeii c?icoiieei, ye /a?ac iaiii eenith ?aaeicothoueny aoaeoe o?aioaeo oa oiio?eacieiio ia ?aaeoeaiinoue noaeei iiae /an AI. Haeiie/aiiy a oiiaao a?aeo I2 a oeaieii IC i?iaeoeoia iaiiio (NI2, iiei/ii? oa ii?iaeiia?aaeii? eeneio, H+-iiiia, iiiia E+) i?ecaiaeeoue aei iaaeiiiy aioo?ioiuei? iiiaaiii? aeoeaiinoi oa?iiiaeueieo noaeei iie?ioee?eoeyoi?iiai ?onea IC, ui i?ecaiaeeoue aei ?o ia?aeeoe/iiai ?icoe?aiiy. O?aioae oa oiio?eacieii aaeueiothoue iaaeiiiy ?I2, onoaathoue aiiienith oeaieie, i, oaeei /eiii, ni?eythoue iiiiaeaiith iiiaaiii? aeoeaiinoi eeioei noaeei. Ineieueee AI noi?iaiaeaeo?oueny aeoeaaoei?th aia?aaoe/iiai iaiiio eeioei IC oa iiaeaeuaiiyi ooai?aiiy i?iaeoeoia IIE (I.N.Oeeeiaiei, 1996), oi aeieeea iaiaoiaeiinoue o i?iaaaeaiii aeineiaeaeaiue c iaoith aea/aiiy aieeao aeacaieo i?aia?aoia ia aeoeaiinoue ieenethaaeueieo oa?iaioia o eeioeiao e?iai oa i?ioeane IIE i?e AI. ?acoeueoaoe aeineiaeaeaiue iieacaee, ui /a?ac 6-8 aiaeei iiney iiaeoeoei? AI o ne?iaaooei e?iai aenia?eiaioaeueieo oaa?ei iaei iinoea caieueoaiiy aiinoo aoi?eiieo i?iaeoeoia IIE, cieaeaiiy AIA oa iiaeaeuaiiy ?iaith INI. sseui aeoiaeii aeaii aea/a?ieo iieacieeia i?eeiyoe ca 100%, oi eiioeaio?aoeiy OAE-aeoeaieo i?iaeoeoia IIE c?inoaea ia 19,9%, AIA cieceeany ia 38,4%, a aiino INI iiaeaeueany ia 78%. Cia/ia aeoeaaoeiy i?ioeania IIE niiaiaaeaea ca /anii ic iayaieie (ia 45,0-49%) iaaeiiiyi ?I2 o oeaieii IC, cieaeaiiyi ia 29,5-45,8% (P<0,01) aeoeaiinoi NAeA oa iiaeaeuaiiyi ia 38,7-51,9% (P<0,001)- EAeA. Ha 8-ie aiaeeii aeineiaeo ciaioeeanue aeoeaiinoue ?-AOAeA i A-6-OAeA ia 23,7 oa 21,8% aiaeiiaiaeii. Oaeei /eiii, iaie anoaiiaeaii oiniee aca?iica'ycie iiae caaaeueieie ia?aiao?aie ieenethaaeueii-iiiiaethaaeueiiai aiiainoaco- ?I2 a oeaieii IC, aeoeaiinoth aeaaiae?iaaiac o iaeo?ioieueieo a?aioeioeeoao e?iai oa i?ioeanaie IIE iiae /an ?icaeoeo AI. Oea yaeeiny ia?aaeoiiaith aeey i?iaaaeaiiy aeineiaeaeaiue aieeao ia oei i?ioeane o?aioaeo oa oiio?eacieiio, ye caniaia, ui ia?aoeiaeaeathoue ?icaeoeo aiiieni? IC i?e AAI. ?acoeueoaoe aeineiaeia iieacaee, ui o?aioae oa oiio?eacieii iaee nooo?aee aioeieneaeaioiee aoaeo, ui i?ecaaei aei ciaioaiiy ia 12,3 i 14,2% aiinoo a ne?iaaooei e?iai OAE-aeoeaieo i?iaeoeoia IIE, iiaeaeuaiiy ia 15,25 oa 25,8% AIA, cieaeaiiy ia 34,8 oa 34,0% ?iaith INI aiaeiiaiaeii i?aia?aoai. Aeineiaeaeaii caniae caaaaeeee cieaeaiith aeoeaiinoi NAeA, ?-AOAeA, A-6-OAeA oa iiaeaeuaiith aeoeaiinoi EAeA. Io?eiaii ia aenia?eiaioaeueiie iiaeaei AI iiceoeaii ?acoeueoaoe i?i ei?aaoth/ee aieea o?aioaeo oa oiio?eacieiio ia ?I2, ?aaeoeaiinoue noaeei, i?ioeane IIE oa aeoeaiinoue aeaaiae?iaaiac iineoaeeee iiaenoaaith aeey eeiii/ii? ioeiiee ?o aoaeoeaiinoi o oai?eo ia AI. ?acoeueoaoe aeineiaeaeaiue iieacaee, ui o oai?eo ia iaa?yeiao oi?io AI na?aaeiuei? aaaeeinoi, ii?yae c oa?aeoa?ieie aeey oei?? oi?ie AI neiioiiaie, iiae /an i?eaoooy aei noaoeiiia?o iaee iinoea iiaeaeuaiiy ?iaith ?-aiieace e?iai, caieueoaiiy aiinoo caaaeueiiai aiei?oaiio, iiii?iee eaeeioeeoic, iaaaeeei ciiie a?oa?iaeueiiai oeneo oa /anoioe ioeueno. Oae, o ia?oi? a?oie oai?eo ?iaaiue ?-aiieace neeaa 83,5+9,0 (a/a_e), aiino caaaeueiiai aiei?oaiio 30,1+6,4 (ieiieue/e), eaeeioeeoia 11,3+0,6 (109/e). A?oa?eaeueiee oene 132+5/79+2 ii. ?o. no., /anoioa ioeueno 88+2 a 1 oa. O ae?oaie a?oii oai?eo aeacaii aeua iieacieee noaiiaeee:??-aiieaca o ne?iaaooei e?iai 89,7+10,2 (a/a_e), caaaeueiee aiei?oaii 34,4+6,2 (ieiieue/e), eaeeioeeoe 11,7+0,7 (109/e), a?oa?eaeueiee oene 126+4/81+4 ii. ?o. no.,/anoioa ioeueno 93+3 a 1 oa. Iaeii?iaeiinoue a?oi oai?eo ca eeiii/ieie i?iyaaie oai?iae, ?acoeueoaoaie iino?oiaioaeueieo oa eaai?aoi?ieo aeineiaeaeaiue i?e iaaeoiaeaeaii aei noaoeiiia?o aeicaieeei i?iaanoe ii?iaiyeueiee aiaeic aoaeoeaiinoi eiiieaenii? aacenii? oa?aii? i?e eieoaaiii oai?eo ic aeei?enoaiiyi o?aioaeo oa oiio?eacieiio. I?e ioeiioei aoaeoeaiinoi i?iaaaeaii aeineiaeaeaiiy c aea/aiiy i?iaeoeoia IIE oa aeoeaiinoi aeaaiae?iaaiac o iaeo?ioieueieo a?aioeioeeoao e?iai. Oni iieacieee aecia/aee i?e iaaeoiaeaeaiii aei noaoeiiia?o oa a aeeiaiioei, a i?ioeani eieoaaiiy (3, 5, 7 aeiae oa ia?aae aeieneith). Iiae /an i?iaaaeaiiy aacenii? oa?aii? ie ea?oaaeeny no/anieie i?eioeeiaie eiina?aaoeaiiai eieoaaiiy AI (A.A.Iieeoaineiaia e ae?., 1994; I.A.Eaaiia e ae?., 1998; TH.A.Eaaiia, A.A.ssniaoeia, 1998). Oai?ei ae?oai? a?oie e?ii aacenii? oa?aii? i?ecia/aee o?aioae oa oiio?eacieii ca aeacaiith aeua noaiith. ?acoeueoaoe eeiii/ieo aeineiaeaeaiue naiae/aoue i?i oa, ui o oai?eo iaio a?oi i?e iaaeoiaeaeaii aei noaoeiiia?o niinoa?iaaeiny iiaeaeuaiiy aiinoo o ne?iaaooei e?iai ia?aeiieo i?iaeoeoia IIE (aei?iiaeo eaoiiia oa aei?iiaeo eii'thaao) ia 33-50% o 1-e a?oii oa ia 38-60% o ae?oaie a?oii o ii?iaiyiii c aeiii?aie. Iaeii/anii iaei iinoea iaeiie/aiiy aoi?eiieo i?iaeoeoia IIE- IAeA ia 6-7%. Aeoeaiinoue NAeA aoea cieaeaiith ia 28,2-30,3%, a EAeA- iiaeaeuaiith ia 21,2-22,6%. Ciaioaiith aoea aeoeaiinoue aeaoo iioeo oa?iaioia (A-6-OAeA i ?-AOAeA) ia 18,2-20,4% oa 16,4-17,2% aiaeiiaiaeii. I?iaaaeaia eiiieaenia eiina?aaoeaia oa?aiiy oai?ei AI ia?oi? a?oie ia i?ecaaea aei nooo?aeo ciii i?iaeoeoia IIE o ne?iaaooei e?iai. Oieueee o aeaiue aeienee oai?eo ic noaoeiiia?o niinoa?iaaeiny cieaeaiiy, o ii?iaiyiii c aeoiaeieie aeaieie, aiinoo aei?iiaeo eaoiiia (0,050+0,001 i?ioe 0,064+0,001, P<0,001) oa IAeA (0,269+0,002 i?ioe 0,276+0,003, P<0,005). Cia/ii c?ooaiiy iieacieeia i?iaeoeoia IIE niinoa?iaaeeny o 2-i? a?oie oai?eo, yei io?eioaaee e?ii aacenii? oa?aii? o?aioae oa oiio?eacieii. Ii/eiath/e c 5-o nooie e aei aeiy aeienee o oai?eo oei?? a?oie iaei iinoea caeiiiii?ia ciaioaiiy aiinoo a ne?iaaooei e?iai aei?iiaeo eaoiiia (0,050+0,001 - 0,058+0,001 i?ioe 0,064+0,001, P<0,001), aei?iiaeo eii'thaao (0,245+0,002 - 0,256+0,002 i?ioe 0,265+0,001, P<0,001) oa IAeA (0,262+0,001 - 0,268+0,001 i?ioe 0,273+0,002, P<0,005). Iaaii ciiie aeyaeaii i?e aea/aiii aeoeaiinoi aeaaiae?iaaiac. O oai?eo 1-i? a?oie ia /an aeienee c noaoeiiia?o niinoa?iaaeiny noaoenoe/ii ai?iaiaeia iiaeaeuaiiy aeoeaiinoi NAeA ia 24,6%, cieaeaiiy aeoeaiinoi EAeA ia 13,1% o ii?iaiyiii c oiiiaeie ca/aiiyie. Aeoeaiinoue ?-AOAeA oa A-6-OAeA ciiithaaeany iacaeiiiii?ii. Nooo?ai ciiie aeoeaiinoi aeaaiae?iaaiac a i?ioeani eieoaaiiy aeyaeaii o oai?eo 2-i? a?oie. C 7-i? aeiae aiae ii/aoeo eieoaaiiy ic aeei?enoaiiyi o?aioaeo oa oiio?eacieiio niinoa?iaaeiny iiaeaeuaiiy aeoeaiinoi NAeA ia 23,0-32,6%, iaaeiiiy aeoeaiinoi EAeA ia 15,2-16,2%, caieueoaiiy aeoeaiinoi ?-AOAeA oa A-6-OAeA (iiae /an aeienee) ia 15,8-19,8% oa 22,9% aiaeiiaiaeii. Aeei?enoaiiy eiiieaenii? eiina?aaoeaii? oa?aii? o eiio?ieueiie a?oii oai?eo i?ecaiaeeei aei ciaioaiiy iioieneeaoei?, ii?iaeicaoei? oaiia?aoo?e, ioeuena, a?oa?iaeueiiai oeneo, onoaaiiy ii 5-6 aeiai aieueiaiai neiae?iio oa ii 3-e aeiae ia?aco eeoeiaieea, iieiioaiiy caaaeueiiai noaio. Ha 5-o aeiao iiaa?oaeeny aei ii?ie ?iaaiue ?-aiieace, aiino caaaeueiiai aiei?oaiio, eieueeinoue eaeeioeeoia o e?iai. Ha /an aeienee oai?eo c noaoeiiia?o cieceany aiino o e?iai aei?iiaeo eaoiiia oa IAeA, iiaeaeueeanue aeoeaiinoue NAeA oa ciaioeeanue EAeA. O oai?eo, yeei ?acii c aaceniith oa?aii?th i?ecia/aee o?aioae oa oiio?eacieii, aeeiaiiea iieiioaiiy eeiii/ieo i?iyaia caoai?thaaiiy, ii?iaeicaoei? eaai?aoi?ieo iieacieeia, c?ooaiue o aeoeaiinoi oa?iaioia oa i?iaeoeoia IIE aoea aieueo ni?eyoeeaith. C 3-i? aeiae aiae ii/aoeo canoinoaaiiy i?aia?aoia onoaaany aieueiaeo neiae?ii, c 2-i? aeiae ia?ac eeoeiaieeo, c 3-i? aeiae iiaa?oaeeny aei ii?ie ?-aiieaca, caaaeueiee aiei?oaii, eieueeinoue eaeeioeeoia. C i'yoi? aeiae niinoa?iaaeiny ciaioaiiy aiinoo o ne?iaaooei e?iai ia?aeiieo i?iaeoeoia IIE oa IAeA, a c 7-i? aeiae iiaeaeueeany aeoeaiinoue NAeA, ciaioeeany- EAeA, aeyaeaii iiaeaeuaiiy aeoeaiinoi A-6-OAeA oa ?-AOAeA. Oea ni?eyei aieueo ?aiiueiio, ia 2-3 aeiao, iaeoaeaiith oai?eo oa nei?i/aiith ia?aaoaaiiy ?o o noaoeiiia?i. sseui o oai?eo, yei io?eioaaee o iiaiiio ianyci aacenio oa?aiith na?aaeiie eieei-aeaiue neeaa 10,6+0,8, oi i?e eieoaaiii oai?eo ic canoinoaaiiyi o?aioaeo oa oiio?eacieiio aii aei?iaithaaa 8,4+0,5 (P<0,02). Aiaeic ?acoeueoaoia aenia?eiaioaeueieo oa eeiii/ieo aeineiaeaeaiue aeicaiey? ?aeiiaiaeoaaoe o?aioae oa oiio?eacieii o yeinoi caniaia iaoiaaiaoe/ii? oa?aii? aeey oe?ieiai aeei?enoaiiy i?e eieoaaiii oai?eo ia AI. Aeniiaee 1. A i?ioeani ?icaeoeo aino?iai aenia?eiaioaeueiiai iaie?aaoeoo o iiaeoeoieiaie caeici ciaioo?oueny oeaieiiee e?iaino?oi, cieaeo?oueny iai?oaa eenith, ciiith?oueny ?aaeoeaiinoue noaeei iie?ioee?eoeyoi?iiai ?onea, iayaiinoue ii?ooaiue yeeo caeaaeeoue aiae /ano c iiiaioo aiaeoai?aiiy iaie?aaoeoo oa eiai oi?ie. 2. I?e aino?iio aenia?eiaioaeueiiio iaie?aaoeoi aeoeaicothoueny i?ioeane ia?aeeniiai ieeneaiiy eiiiaeia, ui noi?iaiaeaeo?oueny caieueoaiiyi OAE-aeoeaieo i?iaeoeoia ia?aeeniiai ieeneaiiy eiiiaeia, cieaeaiiyi aioeieneaeaioii? aeoeaiinoi oa caieueoaiiyi ?iaith iieaeoe na?aaeiuei? iane o ne?iaaooei e?iai. Cieaeo?oueny aeoeaiinoue NAeA, ?-AOAeA, A-6-OAeA oa iiaeaeuo?oueny aeoeaiinoue EAeA o iaeo?ioieueieo a?aioeioeeoao e?iai. ?icaeaa?oueny eiiiainiaaiee iaoaaiei/iee aoeeaeic. 3. Ciaioaiiy oeaieiiiai e?iaino?oio, iaaeiiiy iai?oae eenith, ciiie ?aaeoeaiinoi noaeei iie?ioee?eoeyoi?iiai ?onea o iiaeoeoieiaie caeici, aeoeaaoeiy i?ioeania ia?aeeniiai ieeneaiiy eiiiaeia, c?ooaiiy aeoeaiinoi aeaaiae?iaaiac ? aaaeeeaeie oaeoi?aie o iaoiaaiaci aino?iai iaie?aaoeoo i iathoue oinio i?e/eiii-ianeiaeeiao caeaaeiinoue. 4. O?aioae oa oiio?eacieii a oiiaao aino?iai aenia?eiaioaeueiiai iaie?aaoeoo ia iiia?aaeaeothoue i?ia?anoth/iai cieaeaiiy oeaieiiiai e?iaino?oio o iiaeoeoieiaie caeici, aea aaeueiothoue iaaeiiiy iai?oae eenith o caeici, iathoue ii?iaeicoth/ee aieea ia ?aaeoeaiinoue noaeei iie?ioee?eoeyoi?iiai ?onea iiaeoeoieiai? caeice, i?eaii/othoue i?ioeane ia?aeeniiai ieeneaiiy eiiiaeia, iiaeaeuothoue aioeieneaeaioio aeoeaiinoue o ne?iaaooei e?iai, ia?aoeiaeaeathoue c?ooaiiyi aeoeaiinoi aeaaiae?iaaiac. 5. O oai?eo ia iaa?yeiao oi?io aino?iai iaie?aaoeoo aeoeaothoueny i?ioeane ia?aeeniiai ieeneaiiy eiiiaeia, ui noi?iaiaeaeo?oueny c?inoaiiyi aiinoo a ne?iaaooei e?iai ia?aeiieo i?iaeoeoia ia?aeeniiai ieeneaiiy eiiiaeia- aei?iiaeo eaoiiia, aei?iiaeo eii'thaao oa aoi?eiieo i?iaeoeoia- iaeiiiaiai aeiaeueaeaaiaeo. Cieaeo?oueny aeoeaiinoue NAeA, ?-AOAeA, A-6-OAeA oa iiaeaeuo?oueny aeoeaiinoue EAeA o iaeo?ioieueieo a?aioeioeeoao e?iai. 6. Canoinoaaiiy o?aioaeo oa oiio?eacieiio o oai?eo ia aino?ee iaie?aaoeo nei?i/o? oa?iiie ii?iaeicaoei? eeiii/ieo i?iyaia oai?iae (aieueiaee neiae?ii, ia?ac eeoeiaieea, iioieneeaoeiy), eaai?aoi?ieo iieacieeia (?-aiieaca, caaaeueiee aiei?oaii, eieueeinoue eaeeioeeoia), aeoeaiinoi aeaaiae?iaaiac (NAeA, EAeA, ?-AOAeA, A-6-OAeA), aiinoo i?iaeoeoia ia?aeeniiai ieeneaiiy eiiiaeia (aei?iiai eaoiie, aei?iiai eii'thaaoe, iaeiiiaee aeiaeueaeaaiae), ui ni?ey? aieueo ?aiiueiio iaeoaeaiith oai?eo oa ciaioo? oa?iii ia?aaoaaiiy ?o o noaoeiiia?i. Aeineiaeaeaiiyie anoaiiaeaii, ui o?aioae oa oiio?eacieii ia?aoeiaeaeathoue ?icaeoeiai aiiieni? iiaeoeoieiai? caeice, ii?iaeicothoue noaeeiio ?aaeoeaiinoue, i?eaii/othoue i?ioeane ia?aeeniiai ieeneaiiy eiiiaeia, /eiyoue ei?aaoth/ee aieea ia ieenethaaeueii-aiaeiiaii i?ioeane. Oea aeicaiey? ?icaeyaeaoe ?o ye caniae iaoiaaiaoe/ii? oa?aii? aino?iai iaie?aaoeoo oa ?aeiiaiaeoaaoe aeey oe?ieiai canoinoaaiiy o oi?o?ai/iie i?aeoeoei. Oiii/eii I.I. Iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy o?aioaeo oa oiio?iacieiio i?e eieoaaiii aino?iai iaie?aaoeoo (aenia?eiaioaeueii-eeiii/ia aeineiaeaeaiiy) (?oeiien). Aeena?oaoeiy ia caeiaoooy iaoeiaiai nooiaith eaiaeeaeaoa iaaee/ieo iaoe ca oaoii 14.01.03 - Oi?o?aiy, E?einueeee aea?aeaaiee iaaee/iee oiiaa?neoao ii. N.I.Aai?ai?anueeiai, Niioa?iiieue, 1999. Aeena?oaoeiy i?enay/aia aenia?eiaioaeueiiio iaa?oiooaaiith oa eeiii/iie ioeiioei canoinoaaiiy o?aioaeo oa oiio?iacieiio i?e eieoaaiii aino?iai iaie?aaoeoo. Io?eiaii iaie ia aenia?eiaioaeueiie iiaeaei aino?iai iaie?aaoeoo iiceoeaii ?acoeueoaoe uiaei ei?aaoth/iai aieeao o?aioaeo oa oiio?iacieiio ia iai?oao I2, ?aaeoeaiinoue noaeei o iiaeoeoieiaie caeici, i?ioeane ia?aeeniiai ieeneaiiy eiiiaeia i aeoeaiinoue aeaaeae?iaaiac iineoaeeee iiaenoaaith aeey eeiii/ii? ioeiiee ?o aoaeoeaiinoi o oai?eo ia aino?ee iaie?aaoeo. Canoinoaaiiy o?aioaeo oa oiio?iacieiio i?e eieoaaiii oai?eo ia aino?ee iaie?aaoeo ni?ey? aieueo ?aiiueiio, o ii?iaiyiii ic o?aaeeoeieiith aaceniith oa?aii?th, iaeoaeaiith oai?eo oa nei?i/o? /an ia?aaoaaiiy ?o o noaoeiiia?i. ?acoeueoaoe aeineiaeaeaiue aeicaieythoue ?aeiiaiaeoaaoe o?aioae oa oiio?iacieii ye iaoaaaiaoe/ii caniae aeey eieoaaiiy oai?eo ia aino?ee iaie?aaoeo. Eeth/iai neiaa: iaoiaaiaoe/ia iaa?oiooaaiiy, eieoaaiiy, aino?ee iaie?aaoeo, o?aioae, oiio?iacieii. Fomochkin I.I. The Pathogenetic basis of trental and thyotriasolin use in treatment of acute pancreatitis (experimental-clinical study) (manuscript). The dissertation to look for the research degree of candidate of medical science in speciality: 14.01.03 - Surgery, Crimean state medical University named after S.I.Georgievsky, Simferopol, 1999. The dissertation is devoted to the experimental basis and clinical assessment of trental and thyotriasolin use in treatment of acute pancreatitis. The positive results, resived by us in the experimental model of acute pancreatitis, about the corrective influence of trental and thyotriasolin on the oxygen tension, vessels reactivity in the pancreas, processes of peroxide lipid oxydation and activity of dehydrogenases were the basis for clinical assesment their efficiency in patients with acute pancreatitis. The usage of trental and thyotriasolin in treatment of patients with acute pancreatitis helps ealier in comparison with routine basis therapy patients recovery and decrease the time of their staying in the hospital. Results of study alow to recommend trental and thyotriasolin as pathogenetic remedy to treat the patients with acute pancreatitis. The Key Words: pathogenetic basis, treatment, acute pancreatitis, trental, thyotriasolin. Iiaeienaii aei ae?oeo ______________________ Ia'?i 0,9 oiiaieo ae?oeiaaieo a?eooia Oi?iao 60x90/16. Oe?aae 100 i?eii?ieeia. Caiiaeaiiy ?___________________________ Aeaeaaie/ee oeaio? E?einueeiai aea?aeaaiiai iaaee/iiai oiiaa?neoaoo ii. N.I.Aai?ai?anueeiai. 95006, Niioa?iiieue, Aoeueaa? Eaiiia 5/7.

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