Патогенетичне обгрунтування застосування препарату мірамістину при лікуванні хронічних кон’юнктивітів: Автореф. дис… канд. мед. наук / Н.В. Іванова,

?INOEOOO I*IEO OAI?IA ? OEAIIEII? OA?AI??

?i. A. I. O?eaoiaa

?AAIIAA

Iaioe? A?eoi??aia

OAeE 616-092:616.711-002:615.28

IAOIAAIAOE*IA IAA?OIOOAAIIss CANOINOAAIIss

I?AIA?AOO I??AI?NOEIO I?E E?EOAAII?

O?II?*IEO EII’THIEOEA?O?A

14. 01. 18 — I/i? oai?iae

AAOI?AOA?AO

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Iaeana- 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i.
N. ?. Aai?a??anueeiai IIC Oe?a?ie oa Iinoeoooi i/ieo oai?ia i oeaiieiii?
oa?aii? ii. A.I.Oieaoiaa .

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, noa?oee iaoeiaee
ni?a?ia?oiee AIA?IAA Iaae?y Oaaei??aia, ?inoeooo i/ieo oai?ia ?
oeaiieii? oa?ai?? ?i. A. I. O?eaoiaa, ea??aiee a?aeae?eaiiy aeeoy/i?
iooaeueiieia??.

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?, NAAEI Aaeaioei
Aeaaeeneaaiae/, ?inoeooo i/ieo oai?ia ? oeaieiii? oa?ai??
?i.A.I.O?eaoiaa, caa. a?aeae?eaiiyi oaa?oia;

aeieoi? iaaee/ieo iaoe, aeioeaio IAO?OIss Aiae??e Ieoaeeiae/,
Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, aeioeaio eaoaae?e i/ieo
oai?ia.

I?ia?aeia onoaiiaa: Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y,
eaoaae?a i/ieo oai?ia, IIC Oe?a?ie, i.Aeiii?iiao?ianuee.

Caoeno a?aeaoaeaoueny “ 17 ” /a?aiy 1999?. i _12_ aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 41.556.01 a ?inoeooo? i/ieo oai?ia ?
oeaieiii? oa?ai?? ?i. A.I.O?eaoiaa ca aae?anith: 270061, i. Iaeana,
O?aioeocueeee aoeueaa?, 49/51.

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? ?inoeoooo i/ieo
oai?ia ? oeaieiii? oa?ai?? ?i. A.I.O?eaoiaa (aae?ana: 270061, i. Iaeana,
O?aioeocueeee aoeueaa?, 49/51).

Aaoi?aoa?ao ?ic?neaiee “ 17 ” o?aaiy 1999?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? A/aii? ?aaee

aeieoi? iaaee/ieo iaoe, i?ioani? Iiiiia?/oe A.N.

Caaaeueia oa?aeoa?enoeea ?iaioe TC «Caaaeueia oa?aeoa?enoeea ?iaioe»

Aeooaeuei?noue oaie. Eii’thieoea?oe ca /anoioith caeiathoue iaeia c
ia?oeo i?noeue na?aae an??? iaoieia?? i?aaio ci?o (Iae/oe TH.O.,
I?eoe?ia N.A., 1988). Ca?aeii c aeaieie aaoi??a, na?aae oai?eo, ye?
caa?ioeeny ii aeiiiiiao a i/i? iaaee/i? caeeaaee, 39,7% neeaaeathoue
oai?? ia eii’thieoea?oe ? caoai?thaaiiy aeiiii?aeiiai aia?aoo iea.

Iaea?eueo oe?iei ?iciianthaeaeai? eii’thieoea?oe ?ioaeoe?eii? ? a??onii?
ao?ieia??, aea /ano?oa ao?ieia?y caoai?thaaiiy caeeoa?oueny
0iac’yniaaiith, iniaeeai i?e o?ii?/ieo oi?iao, ? /enei ?o ca?eueoo?oueny
c eiaeiei ?ieii (Iaaeaaae?a A.A., 1979; Iae/oe TH.O., 1983).
Iaaeinoaoiuei aoaeoeaia e?eoaaiiy aino?eo eii’thieoea?o?a (AE) ni?e/eiy?
aei ia?aoiaeo i?ioeano o o?ii?/io oi?io, yea oa?aeoa?eco?oueny ieyaei
o?eaaeei ia?aa?aii, ei?ioeeie ia??iaeaie ?ai?n?? ? /anoeie ?aoeeaeeaaie,
caaaeath/e oai?iio no?aaeaeaiue i?ioyaii aaaaoueio ?ie?a, ?iiae? anueiai
aeeooy. A?aei?/aii, ui e?eoaaiiy oaeeo eii’thieoea?o?a caaaeaee
neeaaeia ? iaeiaoaeoeaia, ine?eueee ?ai?oa aeyaeaia i?e?iaia oei?a aaea
ia ? i?e/eiith o?ii?/iiai eii’thieoea?oo (OE), ? a?i noa? ?acenoaioiei
aei e?eoaaiiy, yea ?ai?oa i?iaiaeeeiny (Eav?i E., Alexander J.A., 1995).
Oiio ?ic?iaea no/anieo aoaeoeaieo iaoiae?a e?eoaaiiy caiaeueieo
caoai?thaaiue eii’thieoeae ia? aaaeeeaa iaaeeei-nioe?aeueia cia/aiiy.

Iaoiaaiac ?icaeoeo OE ia oeae /an iiai?noth ia ?ice?eoee. A?aeiii, ui
o?ii?/ia caiaeaiiy eii’thieoeae iiaea ?icaeaaoeny ia o?eueee a
?acoeueoao? i?e?iaiiai ian?iai?iiy eii’thieoeaaeueii? ii?iaeieie, aea e
i?e o?eaaeiio iiae?aciaii? oeaiei eii’thieoeae a?yie, noi?iii?ie o?eaie,
i?neyiia?aoe?eieie oaaie, eiioaeoieie e?icaie (Sugar A., Meyer R.F.,
Fowler S.A., Korbd D.R., 1984; Friedman T., Friedman Z., 1984; Jolson
A.S., Jolson S.C., 1984). I?e oeueiio ii?oieia?/i? ? iaoio?i?/i? ci?ie o
oeaieiao eii’thieoeae ?aeaioe/i? oaeei i?e i?e?iaiiio OE. Ia aeoieo
Iae/oe TH.O. (1983), OE iaaoaa? aeanoeaino? ?ioiiiaoieia?/iiai
o?aaeaiiy. I?eeeaaeii oaeiai aooi?ioiiiai eii’thieoea?oo ? aaniyiee
eaoa? (E?ieaanueea ?.E., 1987; O?ei/oe A.A. c niiaaao., 1975, 1979,
1980).

O iaoiaaiac? caiaeueieo caoai?thaaiue i?aaia ci?o aei oaia? aaaeeeaa
cia/aiiy iaaoaa? aea/aiiy aeoeaiino? neeiath/i?, o?a?eiie?oe/ii? ?
?ioiii? nenoai, a oaeiae ?o aca?iiae?? (Eiaae ?.I., Iaoaeeoeeia ?.I.,
Iao?aoeueea I.N., 1992; Aeaaoy?aiei O.A., 1992, 1997; Aaiaeaeee ?.E. c
ni?aaao., 1999; ?ai?ia A.A. c ni?aaao., 1999). Aeine?aeaeaiiy o oeeo
iai?yieao aaaeeea? ye c oai?aoe/ieo iiceoe?e — aea/aiiy noi??i
iaoiaaiaco o?ii?/iiai caiaeaiiy, oae ?c i?aeoe/ieo — ?ic?iaee
iaoiaaiaoe/ii iaa?oioiaaieo i?aeoiae?a aei e?eoaaiiy (Iaoaeeoeeia ?.I.,
Eaaeoeueea A.A., Iao?aoeueea I.N., 1997). Aiaeia?/ieo aeine?aeaeaiue i?e
OE ia i?iaiaeeeiny.

Iayni?noue ao?ieia?? ? iaoiaaiaco OE iiynith? a?aenooi?noue aei oeueiai
/ano o a?eueoino? aeiaaee?a aenieiaoaeoeaieo iaoiae?a e?eoaaiiy. Ia
aeoieo a?eueoino? aaoi??a, iaeeoaeoeai?oeie i?e i?noeaaiio e?eoaaii? OE
? i?aia?aoe a?oie aioenaioee?a, noeueoai?eai?ae?a, aioea?ioee?a,
eiia?iiaai? i?aia?aoe, i?aia?aoe ?ineeiiiai iioiaeaeaiiy (Nabil Yarudi,
Bruce Golden, 1975; Ae??aa C.A., 1988; Ii?icia A.?., sseiaeaa I.A.,
1998). E?eoaaiiy oeeie i?aia?aoaie ia caaaeaee ni?e/eiy? aei aee?eoaaiiy
oai?iai, ia caiia?aa? iiya? ?aoeeaeea?a ? /anoi aeyaey? ?ioiiaeai?aneaio
ae?th a ina?aaeeo caiaeaiiy.

Ca?ac i?iaeiaaeo?oueny iiooe iiaeo e?ea?nueeeo cania?a, ye? iathoue
oe?ieo aioei?e?iaio ae?th ? iaeii/anii ii?iae?cothoue oaeoi?e
niaoeeo?/iiai caoenoo ? ?ioiii? ?acenoaioiino? i?aai?cio (Iiaeeaanueeee
N.TH., 1999).

?ic?iaeaiee ae.i.i. i?io. E?eaioa?iei TH.N. ? ?oaeueei A.I. (1984) iiaee
?ioiiiiaeoethth/ee aioenaioee a?oie eao?iiieo iiaa?oiaai-aeoeaieo
?a/iaei (IA?) — i??ai?noei — iaeaaeeoue aei iaeneeuei?oeo aioenaioee?a
na?aae a?aeiieo IA? (Iaoaaeianueeee A.?., 1996). Aeiaaaeaii, ui 0,01%
aiaeiiai ?ic/eio i??ai?noeio ia? ae?aaeaio aioei?e?iaio, aioea??onio,
i?ioea?eaeiao ? aioeoeai?aeio ae?th. I?e oeueiio, i?aia?ao iaeaaeeoue
aei iecueeioiene/ieo, ine?eueee ia aeyaey? oe?aeeeai? ae?? i?e o?eaaeiio
canoinoaaii?, ia ia? iooaaaiieo, eaioea?iaaiieo ? aea?a?coth/eo
aeanoeainoae (Aic?aiia I.O., Iana/ieeia N.I., E?eaioa?i TH.N., 1984;
E?eaioa?i TH.N., ?oaeueei A.I., 1995). Ie??i aeniei? aaeoa?eoeeaeii?
caeaoiino?, i??ai?noei ia? ?ioiiiiaeoethth/? aeanoeaino?, aieeaath/e ia
iaia?aie ?ioiieiiiaoaioieo ee?oei (E?eaioa?i TH.N., Oao?ia A.I., 1990;
E?eai?o/aiei TH.E., E?eaioa?i TH.N., Ia?aiieeia N.N., 1994, 1997).
Aeiaaaeaii, ui ?ioiiaae’thaaioi? aeanoeaino? i??ai?noeio caiaeyoueny aei
noeioeyoe?? ee?oeiii? eaiee ?ioi?oaoo (Oao?ia A.I., Eiaaeaiei A.A.,
E?eaioa?i TH.N., 1990; E?eaioa?i TH.N., 1992). I?aia?ao aaea ciaeoia
oni?oia canoinoaaiiy o o??o?a??, o?aaiaoieia??, eaiaono?ieia?? aeey
c?ioaiiy ?ai ? ii?e?a, i?iieaaiiy o?nooeueieo oiae?a i?e e?eoaaii?
caiaeueieo caoai?thaaiue, o a?iaeieia??, aeooa?noa?, o?ieia??,
aea?iaoiaaia?ieia?? ? ioiea?eiaieia?? (Neaaeia A.?., Oieeaaee I.?.,
1996; Oanaiei A.I., E?eaioa?i TH.N., 1996; Eo/a?aiei TH.I. c ni?aaao.,
1990; Oi?no?a I.I., Aaeiae/aiei TH.I., 1990; I?eyanueeee I.?. c
ni?aaao., 1996; E?eaioa?i TH.N., E?eai?o/aiei TH.E., 1997; Caaae?e I.A.,
1997).

Canoinoaaiiy ?ioiiiiaeaethth/iai aioenaioeea i??ai?noeio ye
iiaa?oiaai-aeoeaii? ?a/iaeie a iooaeueiieia??, c iaoi? oi/ee ci?o,
aei?aaaeaia ? ia?niaeoeaia. O e?oa?aoo?? iathoue i?noea iia?aeiieaiiy
i?i canoinoaaiiy i??ai?noeio eeoa aeey e?eoaaiiy aaaeeeo
aenia?eiaioaeueieo ii?e?a i/ae (?an?i I.A., sseeiaiei N.A., E?eaioa-?i
TH.N., 1997).

Ca?aeii c ??oaiiyi Oa?iaeieia?/iiai eii?oaoo IIC Oe?a?ie a?ae 28.11.96.,
aeicaieai? ee?i?/i? aeine?aeaeaiiy i??ai?noeiiaeo i/ieo e?aiaeue (IIE),
ui i?noyoue 0,01% i??ai?noeio a 0,9% ?cioii?/iiio ?ic/ei? iao??th
oei?eaeo o E?einueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? ?i. N.?.
Aai?a??anueeiai ? a ?inoeooo? i/ieo oai?ia ? oeaieiii? oa?ai?? ?i.
A.I.O?eaoiaa AII Oe?a?ie.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?i-aioa
aeeiioaaeanue o a?aeiia?aeiino? c ieaiii iaoeiai-aeine?aeieo ?ia?o
E?einueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. N.?.
Aai?a??anueeiai. Aiia ? o?aaiaioii eiiieaenii? oaie ? aea?ae?a?no?aoe??
01.91.0009707, -«Aea/aiiy iiaeeeainoi aeei?enoaiiy IA? o iie?iaiiaiei?,
aiioaoiieiai? oa iaaeeoeeii. Aea/aiiy aieeao IA? i?e caiaeueieo
caoai?thaaiiyo i?aaiia ci?o».

Iaoa ?iaioe. I?aeaeueoe aoaeoeai?noue e?eoaaiiy oai?eo ia o?ii?/i?
eii’thieoea?oe ia iniia? aea/aiiy aeayeeo noi??i iaoiaaiaco
caoai?thaaiiy (aaiinoaoe/i? ? ?ioii? ii?ooaiiy) ? i?noeaaiai
canoinoaaiiy i?aia?aoo i??ai?noeio.

Caaea/? aeine?aeaeaiiy. 1. Aeine?aeeoe oaeoi?e nenoaiiiai ? i?noeaaiai
(oeaieia eii’thieoeae, ne?cia ??aeieia) aaiinoaco i?e o?ii?/ieo
eii’thieoea?oao.

2. Aea/eoe ?ioiiaeoeai? aeanoeaino? eii’thieoeae o oai?eo ia OE.

3. Aeine?aeeoe aca?iica’ycie nenoai aaiinoaco ? ?ioi?oaoo i?e OE.

4. Aea/eoe aieea i??ai?noeio ia i?ioeane o?a?eiie?co o aeeiai?oe?
e?eoaaiiy oai?eo ia OE.

5. Aecia/eoe aoaeoeai?noue i?noeaaiai canoinoaaiiy i??ai?noeio o oai?eo
ia OE.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aeyaeai? ii?ooaiiy o
nenoai? caaaeueiiai ? i?noeaaiai (oeaieia eii’thieoeae) aaiinoaco oa
?ioi?oaoo o oai?eo ia o?ii?/i? eii’thieoea?oe c ia?aaaaith i?noeaaeo
(oeaieia eii’thieoeae) i?ioean?a iaae caaaeueieie. I?e oeueiio
anoaiiaeaii, ui o oai?eo ia o?ii?/i? eii’thieoea?oe ii?ooaia ??aiiaaaa
i?ae aaiieiaaoeyoe??th ? o?a?eiie?cii o oeaieiao eii’thieoeae, i?e/iio
i?ioeane o?a?eiie?co ia “a??aiiaaaeothoue” i?ioean?a aaiieiaaoeyoe??.

Aia?oa aeyaeai? ?ioiiaeoeai? aeanoeaino? eii’thieoeae o oai?eo ia
o?ii?/i? eii’thieoea?oe, ye? i?eai?/othoue ooieoe?iiaeueio aeoeai?noue
e?ioioeeo?a ? iiiioeeo?a, ? ia?aeaeueii noeioeththoue oaaioeeoa?io
aeoeai?noue iaeo?io?e?a, ui aaaea aei ooieoe?iiaeueiiai ii?ooaiiy
ee?oeiii? eaiee ?ioi?oaoo o oeeo oai?eo. Aia?oa aea/aiee aca?iica’ycie
nenoaie aaiinoaco ? ?ioi?oaoo i?e o?ii?/iiio eii’thieoea?o?.
Anoaiiaeaii, ui iaaeinoaoi?e ??aaiue i?ioean?a o?a?eiie?co o oeaieiao
eii’thieoeae iaoiiaeaiee oaeiae cieaeaiiyi ooieoe?iiaeueii? aeoeaiino?
?ioiieiiiaoaioieo ee?oei.

Aeyaeaia caeaoi?noue i?aia?aoo i??ai?noeio aeoea?coaaoe i?ioeane
o?a?eiie?co a ina?aaeeo caiaeaiiy o oai?eo ia o?ii?/i? eii’thieoea?oe,
ui ni?ey? ?icniieooaaiith “o?a?eiiaiai aa?’??o” ? a?eueo oaeaeeiio
cae?i/aiith caiaeaiiy.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Iaea?aeai? a ?acoeueoao?
i?iaaaeaieo aeine?aeaeaiue aeai? aeicaieythoue ?aeiiaiaeoaaoe aeey
oe?ieiai aeei?enoaiiy a iooaeueiieia?/i?e i?aeoeoe? iiaee
iiaa?oiaai-aeoeaiee aioenaioee i??ai?noei, yeee ii?yae c
?ioiiiiaeaethth/eie aeanoeainoyie aeyaey? ei?aaoth/o ae?th ia i?ioeane
o?a?eiie?co o oeaieiao eii’thieoeae.

?ic?iaeaiee iiaee iaoiaaiaoe/ii i???ioiaaiee niin?a e?eoaaiiy oai?eo ia
o?ii?/i? eii’thieoea?oe (i??i?eoaoia aeia?aeea ia cayao ? 99031218),
yeee iieyaa? a ?inoeeyoe?yo o eii’thieoeaaeueio ii?iaeieio aeaio
i?aia?ao?a — nio?aaeaeno ? i??ai?noeio. Eiai canoinoaaiiy i?aeaeuo?
aoaeoeai?noue ? iie?ioo? ye?noue e?eoaaiiy oai?eo ia o?ii?/i?
eii’thieoea?oe: nei?i/o?oueny o?eaae?noue caaino?aiiy ia 30,3%, /enei
ui??/ieo ?aoeeaeea?a ciaioo?oueny o 1,8 ?ace, ia??iae ee?i?/ii? ?ai?n??
iiaeiaaeo?oueny ia 45,2%, o /anoeie oai?eo (33,9%), ca aeaieie ie?aieo
niinoa??aa/?a (1-2 ?iee), aeinyaa?oueny ee?i?/ia iaeoaeaiiy.

?ic?iaeaiee niin?a ai?iaaaeaeaiee o i?aeoeeo I, II, III
iooaeueiieia?/ieo a?aeae?eaiue ?anioae?eainueei? ee?i?/ii? e?ea?i? ?i.
I.I.Naiaoea i. N?ioa?iiiey, o a?aeae?eaii? aeeoy/i? iooaeueiieia??
?inoeoooo i/ieo oai?ia ? oeaieiii? oa?ai?? ?i. A.I.O?eaoiaa AII Oe?a?ie,
iooaeueiieia?/ieo eaa?iaoao iie?ee?i?e ?3 ? ?6 i.N?ioa?iiiey.

Iaea?aeai? ?acoeueoaoe aeena?oaoe?? iiaeooue aooe aeei?enoai? a
o/aiai-iaoiaee/ieo iin?aieeao aeey nooaeaio?a ? e?ea??a-?ioa?i?a
iooaeueiieia?a.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii naiino?eii aeeiiai? ee?i?/i?
niinoa?aaeaiiy 220 oai?eo (408 i/ae) ia aino?? ? o?ii?/i? eii’thieoea?oe
??cii? ao?ieia??.

Naiino?eii i?iaaaeai? aenia?eiaioaeuei? aeine?aeaeaiiy ia?eoa?e/ii?
e?ia?, oeaiei eii’thieoeae ? ne?cii? ??aeeie ia aac? Oeaio?aeueii?
iaoeiai-aeine?aeii? eaai?aoi??? (OeIAeE) E?einueeiai iaae. oi?aa?neoaoo.

Ei?aeyoe?eiee aiae?c iaea?aeaieo ?acoeueoao?a e?eoaaiiy oai?eo ia OE
aeeiiaiee ?acii c iaoeiaei ea??aieeii ae.i.i., no. iaoe. ni?a?ia. I.O.
Aia?iaith.

Iiaee niin?a e?eoaaiiy o?ii?/ieo eii’thieoea?o?a ?ic?iaeaiee ni?eueii c
ae.i.i. I.O.Aia?iaith ? i?io. TH.N.E?eaioa?iei.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiaii ?acoeueoaoe
aeena?oaoeieii? ?iaioe aeiiiaiaeaeenue ia can?aeaiiyo E?einueeiai
iooaeueiieia?/iiai oiaa?enoaa 1997—1998 ??., ?anioae?eainueei?
iaoeiai-i?aeoe/ii? eiioa?aioe?? iooaeueiieia?a, i?enay/aii? 100-??//th c
aeiy ia?iaeaeaiiy i?io. I.N. Aca?iai? 1997 ?. i.N?ioa?iiieue, ia
iaoeia?e eiioa?aioe??, i?enay/ai?e 90-??//th aeaae. I.I.Io/eianueei?
(1998 ?.), ia XXVIII I?aeia?iaeiiio eiia?an? iooaeueiieia?a 1998 ?.
i.Ainoa?aeai (I?aea?eaiaee), ia IV I?aeia?iaeiiio eiia?an?
“?aaa?e?oaoe?y o iaaeeoeei? ? ?ioii?aaa?e?oaoe?y” 1998 ?. i.Ni/?
(?in?y), ia IV I?aeia?iaei?e eiioa?aioe?? iooaeueiieia?a 1998 ?. i.Ee?a.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 9 ae?oeiaaieo
?ia?o, c yeeo 3 noaoo? o aeo?iaeao, 2 — o ca??eao iaoeiaeo ?ia?o
E?einueeiai iaae. oi?aa?neoaoo ?i. N.?.Aai?a??anueeiai, 4 — o ca??eao
iaoa??ae?a eiioa?aioe?e.

Ia’?i ?iaioe. Aeena?oaoe?y ?iciiuo?oueny ia 176 noi??ieao eiii’thoa?iiai
oaenoo, neeaaea?oueny c anooio, 4-o ?icae?e?a, caeeth/aiiy ? aeniiae?a.
O ?iaio? i?eaaaeaii 44 oaaeeoe?, yei ?iciiuothoueny ia 32 noi?iieao, 7
iaethieia, yei iicoyoueny ia 7 noi?iieao, nienie aeei?enoaieo
eioa?aoa?ieo aeaea?ae i?noeoue 231 iacao i ?iciiuo?oueny ia 22
noi?iieao.

Iniiaiee ci?no TC «Iniiaiee ci?no »

I?ae niinoa?aaeaiiyi ia?aaoaaee 220 oai?eo (408 i/ae) c ??cieie
ee?i?/ieie oi?iaie eii’thieoea?o?a. Na?aae oai?eo aoei iaeaea ??aia
/enei in?a /ieia?/i? (50,9%) ? ae?ii/i? (49,1%) noao?. Eiio?ieai aoee 30
caei?iaeo aeiii??a (ia?eoa?e/ia e?ia).

C o?ii?/ieie eii’thieoea?oaie (OE) niinoa??aaeiny 188 oai?eo (376 i/ae)
? aino?ei eii’thieoea?oii (AE) 32 oai?eo (32 iea).

Ca?aeii c eeaneo?eaoe??th A.A.Eaoeiaeueniia (1968 ?.), o ianoaaeaieo
oai?eo ia OE aoee oae? ee?i?/i? oi?ie caoai?thaaiiy: o?ii?/iee
eaoa?aeueiee eii’thieoea?o 81,9% (o?ii?/iee aeaoa?i-eii’thieoea?o 59,6%,
o?ii?/iee iaeaii??aee eii’thieoea?o 17,5%, eae?eiaeueiee eii’thieoea?o
4,8%), o?ii?/iee aea?a?/iee eii’thieoea?o 14,4%, aaniyiee eaoa? 3,7%.

A?e oai?eo eieeaaany o aaeeeiio ae?aiacii? — a?ae 5 aei 80-e ?ie?a (o
na?aaeiueiio 42,4+4,2 ?iee). O?eaae?noue caoai?thaaiiy ia OE neeaaeaea o
niinoa?aaeoaaieo iaie oai?eo a?ae 6 i?nyoe?a aei 30 ?ie?a (o
na?aaeiueiio 8,0+1,1 ?ieo). I?ae a?eii oai?eo ? o?eaae?noth
caoai?thaaiiy aeyaeaii i?yiee ei?aeyoe?eiee ca’ycie: ?c ca?eueoaiiyi
a?eo ca?eueooaaeany aeaai?noue caoai?thaaiiy. An? oai?? ia OE
aaaaoi?aciai e?eoaaeeny ca i?noeai i?iaeeaaiiy aiaoeaoi?ii
o?aaeeoe?eieie iaoiaeaie e?eoaaiiy.

A?eueoa iieiaeie (65,4%) niinoa?aaeoaaieo iaie oai?eo iaee noiooi? i/i?
caoai?thaaiiy, /ano?oa ca ana — o 54,8% aeiaaee?a cono??/aeany a?eiaa
eaoa?aeoa ??ciiai nooiaiy c??eino?, o 5,1% — i?neyiia?aoe?eia aoae?y,
2,9% — a?oeoae?y, o 2,6% — o?ii?/iee aeae??ioeenoeo.

On?i oai?ei ia AE ? OE cai?iaaaeaeoaaee caaaeueiii?eeiyoi?
iooaeueiieia?/i? aeine?aeaeaiiy. O oai?eo ? caei?iaeo in?a i?iaaaeeeeny
aeine?aeaeaiiy ia?eoa?e/ii? e?ia? (aaiieiaaoeyoe?y, o?a?eiie?c,
aeoeai?noue e?ioioeeo?a, iiiioeeo?a, oaaioeeoa?ia aeoeai?noue
iaeo?io?e?a ? aeni?an?y e?ioioeeoaie ?aoeaioi??a aei o?iia?io ?
aeoeaaoi??a ieaci?iiaaio, ca Eonnaeueiaiii A.?. (1987). O oai?eo
aeine?aeaeoaaeeny aeno?aeoe oeaiei eii’thieoeae ca iaoiaeeeith
Ne?iao?iaa A.I. ? ni?aaao. (1976). Aeine?aeaeaiiy o?a?eiie?oe/ii?
aeoeaiino? ne?cii? ?iaeeie i?iaiaeeee ca iaoiaeeeith Niiiaa ?.?. ?
A?aeanueeiai A.A. (1992).

O oai?eo ia aino?ee eii’thieoea?o ia I aoai? aeine?aeaeaiiy (o aino?iio
ia??iae? caoai?thaaiiy) iaie aoei aeyaeaii o nenoaiiiio aaiinoac?
i?aeaeuaiiy on?o iieaciee?a aaiinoaco: aa?aaaoe?eii? aeoeaiino?
o?iiaioeeo?a (ia 18,3% ii??aiyii c ii?iith), oiea?aioiino? ieacie aei
aaia?eio (ia 8,5 %), /ano ?aeaeueoeeo?eaoe?? ieacie (7,4% nei?i/aiiy
ii??aiyii c ii?iith), ??aiy o?a?eiiaaio (ia 31,3%), i?iaeoeo?a
aeaa?aaeaoe?? o?a?ei-o?a?eiiaaio (IAeO) (ia 51,7%). Ia II aoai?
aeine?aeaeaiiy (aoai? ee?i?/iiai iaeoaeaiiy) oe? iieacieee iiaa?oaeeny
aei ii?iaeueieo iaae, ca aeiyoeii o?a?eiie?oe/ii? aeoeaiino? e?ia?, yea
ca?eueoeeany ia 8,7% ii??aiyii c ii?iaeueiei ??aiai.

O oai?eo ia OE oae? iieacieee aaiinoaco o nenoaiiiio e?iai-ieei?, ye:
oiea?aioi?noue ieacie aei aaia?eio, /an ?aeaeueoeeo?eaoe?? ieacie,
i?io?iia?iiaee ?iaeaen, o?iia?iiaee /an, aeoeai?noue o?a?eiace,
o?a?eiie?oe/ia aeoeai?noue, ??aaiue aioeo?iia?io III (AO III) ia
aeoiaeeee ca iaae? ii?ie ia iaio aoaiao aeine?aeaeaiiy. Aea, ia a?aei?io
a?ae oai?eo ia AE, iieaciee aa?aaaoe?eii? aeoeaiino? o?iiaioeeo?a aoa
i?aeaeuaiee ia 12,7% ia iaio aoaiao aeine?aeaeaiiy, oaeiae aoa
i?aeaeuaiee ??aaiue o?a?eiiaaio a?aeiia?aeii ia 28,1% ? ia 34,4%, ?
??aaiue IAeO a?aeiia?aeii ia 48,8% ? 49,4%. Iaea?aeai? aeai? na?ae/aoue,
ui o oai?eo ia OE iathoue i?noea ii?ooaiiy III oace neeiaiiy e?ia?, oace
ooai?aiiy o?a?eio.

I?e aea/aii? aieeao aeno?aeo?a eii’thieoeae ia iieacieee aaiinoaco o
oai?eo ia AE ? OE aeyaeaii ia?aaaao i?noeaaeo (oeaieia eii’thieoeae)
iaae caaaeueieie (o nenoaiiiio e?iaiieei?) ci?iaie iieaciee?a aaiinoaco.
Oae, aeno?aeoe eii’thieoeae oai?eo ia OE aaea o aeo?aeiiio ?icaaaeaii?
(1:100) iaee aeuo eiaaoeyoe?eio ? o?iiaiieanoe/io aeoeai?noue, i?ae
aiaeia?/i? o oai?eo ia AE: i?e OE ca?eueoeeany ia 77,6% oiea?aioi?noue
ieacie aei aaia?eio, i?e AE — ia 81,3%, nei?i/oaaany /an
?aeaeueoeeo?eaoe?? ieacie ia 42,3% i?e OE ? ia 53,4% — o oai?eo ia AE,
ca?eueooaaany i?io?iia?iiaee ?iaeaen ia 25,8% i?e OE ? ia 29,2% — o
oai?eo ia AE, iiaeiaaeoaaany o?iia?iiaee /an o 1,8 ?ace i?e OE ? o 1,2 —
i?e AE, i?aeaeuoaaeany aeoeai?noue o?a?eiace ia 73,8% i?e OE ? ia 87,7%
— i?e AE. Aeno?aeoe eii’thieoeae oai?eo ia OE caa??aaee i?aeaeuai?
iieacieee aaiinoaco a on?o ?icaaaeaiiyo (aei 1:100000), o oie /an, ye o
oai?eo ia AE oae? aeanoeaino? aeno?aeo?a eii’thieoeae aeyaeyeeny o?eueee
o aeo?aeiiio ?icaaaeaii?. Iaea?aeai? aeai? na?ae/aoue i?i iiaeeea?noue
aieeao i?ieiaaoeyioieo oaeoi??a oeaiei eii’thieoeae oai?eo ia OE ia
??aaiue aaiieiaaoeyoe?? o nenoaiiiio e?iaiieei? i?e aeieaaii? ?o o
nenoaiiee e?iaiieei.

I?e aea/aii? o?a?eiie?oe/ieo aeanoeainoae eii’thieoeae aeyaeeinue, ui o
oai?eo ia AE aeno?aeoe eii’thieoeae iioaioe?ththoue o?a?eiie?c ia 9,1%,
a o oai?eo ia OE — ia 31,5%, oiaoi oeaieie eii’thieoeae oai?eo ia OE
i?noyoue iaioa ?ia?a?oi??a o?a?eiie?co, i?ae o oai?eo ia IE. Oaeei
/eiii, o oai?eo ia AE iieacieee aaiieiaaoeyoe?? o nenoaiiiio e?iaiieei?
o aino?ee ia??iae caoai?thaaiiy (I aoai) ca?eueoothoueny, a o?a?eiie?co
— cieaeothoueny, a o ia??iae iaeoaeaiiy (II aoai) iiaa?oathoueny aei
ii?ie iieacieee aaiieiaaoeyoe??, a o?a?eiie?co — i?aeaeuothoueny. O
oai?eo ia OE iieacieee aaiieiaaoeyoe?? ia iaio aoaiao aeine?aeaeaiiy
ca?eueoai?, a iieacieee o?a?eiie?co iaaeeaeathoueny aei ii?ie. I?e/iio,
i?ioean o?a?eiie?co o oai?eo ia OE ia “a??aiiaaaeo?” i?ioeano
aaiieiaaoeyoe??.

I?e aea/aii? aca?iica’yceo nenoai aaiinoaco ? ?ioi?oaoo o nenoaiiiio
e?iaiieei? aeyaeeinue, ui aeni?an?y e?ioioeeoaie ?aoeaioi??a aei
o?iia?io (O?-?IE) o oai?eo ia AE ca?eueoaia o 6,2 ?ace ii??aiyii c
ii?iith o aino?ee ia??iae caoai?thaaiiy ? i?e iaeoaeaii? iiaa?oa?oueny
aei ii?ie; a o oai?eo ia OE ai?no O?-?IE ca?eueoaiee o 3,3 ?ace ia iaio
aoaiao aeine?aeaeaiiy. I?e aeine?aeaeaii? aeni?an?? e?ioioeeoaie
?aoeaioi??a aei aeoeaaoi??a ieaci?iiaaio (o?ie?iaciiai oeio) O?-?IE o
oai?eo ia AE ia ia?oiio aoai? c?inoa? ia 70,2%, (oeaieiiiai oeio) OA-?IE
c?inoa? ia 27,2%, (e?ia’yiiai oeio) EA-?IE o iaaeao ii?ie. Ia aoai?
ee?i?/iiai iaeoaeaiiy o oai?eo ia AE ai?no O?-?IE ? OA-?IE iiaa?oa?oueny
aei ii?iaeueieo iaae, a ai?no EA-?IE c?inoa? ia 44,7%. O oai?eo ia OE ia
iaio aoaiao aeine?aeaeaiiy cieaeaiee ai?no O?-?IE ia 51,8% ? ia 50,0%
a?aeiia?aeii, ai?no OA-?IE cieaeaiee ia 17,3% ? ia 17,0% a?aeiia?aeii, a
EA-?IE iaaeeaea?oueny aei ii?ie.

Oaeei /eiii, yeui cieaeaiiy ??aiy O?-?IE ? OA-?IE o aino?ee ia??iae
caoai?thaaiiy ? aaaeeeaith oiiaith ooai?aiiy o?a?eiiaeo a?aeeeaaeaiue,
ye? ia?aoeiaeaeathoue aaia?ae?caoe?? caiaeueiiai i?ioeano, oi ia aoai?
ee?i?/iiai iaeoaeaiiy, eiee iaiao?aeiei noa? ?ic- niieooaaiiy
“o?a?eiiaiai aa?’??o”, oeae iieaciee c?inoa?. O oai?eo ia OE oe?
iieacieee cieaeai? ia iaio aoaiao aeine?aeaeaiiy ? ia iiaeooue
caaacia/eoe iiaio ae?i?iaoe?th o?a?eiiaeo a?aeeeaaeaiue ia aoai?
ee?i?/iiai iaeoaeaiiy.

Ii?ooaiiy ?ioiii? ?aaoeyoe?? aaiinoaco o oeaieiao eii’thieoeae oai?eo ia
OE i?aeoaa?aeaeoaaeiny oei, ui aeno?aeoe eii’thieoeae i?noeee oaeoi?e,
ye? aaeueioaaee ooai?aiiy O?-?IE a?ae 65,5% o aeo?aeiiio ?icaaaeaii? ?
aei 18,5% o iaeneiaeueiiio ?icaaaeaii? ii??aiyii c ii?iith. O oai?eo ia
AE iiae?aia ae?y aeno?aeo?a eii’thieoeae aoea cia/ii iaioa ae?aaeaia
o?eueee o aeo?aeiiio ?icaaaeaii? ia 32,1% ii??aiyii c ii?iith.

I?e aea/aii? ?ioiiaeoeaieo aeanoeainoae eii’thieoeae aeyaeaii, ui ai?no
?icaoeiooai?thth/eo e?ioioeeo?a (aA-?IE) o nenoaiiiio e?iaiieei? o
oai?eo ia AE aoa i?aeaeuaiee ia 27,8% ia I aoai? aeine?aeaeaiiy ?
cieaeaiee ia II aoai? aeine?aeaeaiiy ia 12,2%, a o oai?eo ia OE ia iaio
aoaiao aeine?aeaeaiiy cieaeaiee a?aeiia?aeii ia 10,4% ? ia 8,7%
ii??aiyii c ii?iith.

?ioiiaeoeaiee aieea aeno?aeo?a eii’thieoeae oai?eo ia AE i?iyaeany
o?eueee o aeo?aeiiio ?icaaaeaii? — iieaciee i?aeaeuoaaany ia 15,7%,
iaaooue, ca ?aooiie ?icaeieoaaiiy aA-?aoeaioi??a ia e?ioioeeoao, a
aeno?aeoe eii’thieoeae oai?eo ia OE cieaeoaaee aA — ?IE ia 27,8% —
12,2% iaeaea o an?o ?icaaaeaiiyo, iiaeeeai ca ?aooiie aeieaaee
aA-?aoeaioi??a ia e?ioioeeoao.

Ai?no AA — ?II (iiiioeeo?a, aeni?anoth/eo ?aoeaioi?e aei Fc-o?aaiaioo
?ioiiaeiaoe?i?a G i M) o oai?eo ia AE ? OE ia iaio aoaiao
aeine?aeaeaiiy nooo?ai ia a?ae??ciyany a?ae ii?ie, aea a ia??iae
iaeoaeaiiy o oai?eo ia OE oeae iieaciee aoa ia 17,5% aeuee, i?ae o
oai?eo ia AE. ?ioiiaeoeaiee aieea aeno?aeo?a eii’thieoeae ia iieaciee AA
— ?II i?iyaeyany o oai?eo ia AE ? OE o?eueee o aeo?aeiiio ?icaaaeaii?: o
oai?eo ia AE ca?eueooaaany ia 16,4%, a o oai?eo ia OE cieaeoaaany ia
17,7%. Iiae?aiee aoaeo a?aeaoany, iiaeeeai, ca ?aooiie ?icaeieoaaiiy Fc
— ?aoeaioi??a iiiioeeo?a o oai?eo ia AE ? ca ?aooiie aeieaaee Fc —
?aoeaioi??a iiiioeeo?a o oai?eo ia OE.

I?e aea/aii? oaaioeeoa?ii? aeoeaiino? iaeo?io?e?a oaaioeeoa?iee ?iaeaen
(O?) o oai?eo ia AE aoa i?aeaeuaiee ia iaio aoaiao aeine?aeaeaiiy
a?aeiia?aeii ia 22,9% ? 26,0%. O oai?eo ia OE ia iaio aoaiao
aeine?aeaeaiiy iieaciee ciaoiaeeany o iaaeao ii?ie. Aeno?aeoe
eii’thieoeae oai?eo ia AE ca?eueooaaee O? ia 74,0% o?eueee o aeo?aeiiio
?icaaaeaii?, a oie /an ye aeno?aeoe eii’thieoeae i?e OE ca?eueooaaee
oeae iieaciee ia 45,8%, a o a?eueoeo ?icaaaeaiiyo i?iyaeyee ?ia?aoth/ee
ooieoe?iiaeueio aeoeai?noue iaeo?io?e?a aoaeo — cieaeoaaee O? ia 17,7%,
aeaiiino?oth/e iiaeeea?noue aieeao ?ioiiaeai?aneaieo oaeoi??a
eii’thieoeae ia nenoaiiee oaaioeeoa?iee iioaioe?ae.

Oaeei /eiii, yeui ?icaeyiooe eiioeaioe?th aino?iai ? o?ii?/iiai
caiaeaiiy ic caaaeueiia?ieia?/ii? iiceoe?? (Iiaao A.3., 1975a., Movat
I., 1985a.), ci?ie o nenoaiiiio aaiinoac? o oai?eo ia AE o aino?ee
ia??iae caoai?thaaiiy ? a ia??iae iaeoaeaiiy, aeyaeai? iaie, iiaeia
?icoe?ieoe ye i?aeoaa?aeaeaiiy i?iyao caoenii-i?enoiniaii? ?aaeoe??
i?aai?cio ia aino?ee caiaeueiee i?ioean o eii’thieoea?. Aeyaeai? iaie
ci?ie o oai?eo ia OE iaee iaoiaaiaoe/io ni?yiiaai?noue, — iaaoaath/e
oa?aeoa? o?ii?/iiai ?ioiiiaoieia?/iiai i?ioeano. I?e oeueiio
ii?oooaaeanue ?ioiia ?aaoeyoe?y aaiinoaco: a?aeaoaaeanue i?a?aoe?y a
ina?aaeie caiaeaiiy o?iia?iiiceoeaieo e?ioioeeo?a, ye? i?aeneethaaee
eieaeueio aaiieiaaoeyoe?th, ui i?iyaeyeinue o oai?eo ia OE a ia??iae
caaino?aiiy ? caa??aaeinue a ia??iae ee?i?/ii? ?ai?n??. Iaeii/anii
aeyaeaii cieaeaiiy i?ioean?a o?a?eiie?co, ui i?iyaeyeinue o cieaeaii?
aeni?an?? e?ioioeeoaie ?aoeaioi??a aei aeoeaaoi??a ieaci?iiaaio ye o
aino?ee ia??iae caoai?thaaiiy, oae ? a ia??iae ee?i?/ii? ?ai?n??.

O ?acoeueoao? i?iaaaeaieo aeine?aeaeaiue anoaiiaeaii, ui ia?aa?a
o?ii?/iiai eii’thieoea?oo noi?iaiaeaeo?oueny i?aeaeuaiiyi i?ioean?a
aaiieiaaoeyoe?? ? o?a?eiie?co, i?e/iio i?ioeane o?a?eiie?co ia
“a??aiiaaaeothoue” i?ioean?a o aaiieiaaoeyoe??. Oaeiae iaea?aeai? aeai?
na?ae/aoue i?i oa, ui ia?aa?a o?ii?/iiai caiaeaiiy o eii’thieoea? (ia
a?aei?io a?ae aino?iai) oa?aeoa?eco?oueny iayai?noth a ina?aaeeo
caiaeaiiy ?ioiiaeoeaieo oaeoi??a, ye? aeieothoue ooieoe?iiaeueio
aeoeai?noue e?ioioeeo?a, iiiioeeo?a ? ia?aeaeueii iioaioe?ththoue
oaaioeeoa?io aeoeai?noue iaeo?io?e?a. An? oe? ci?ie caa??aathoueny ? o
ia??iae ee?i?/ii? ?ai?n?? OE.

I?e aeine?aeaeaii? aieeao i??ai?noeio ia ii?ooaiiy o nenoai? aaiinoaco
iaie aoee aeyaeai? iia? iaoai?cie ae?? oeueiai i?aia?aoo. Iiae aieeaii
i??ai?noeio ?n vitro aeni?an?y e?ioioeeoaie ?aoeaioi??a aei aeoeaaoi??a
ieaci?iiaaio ai?no iieacieea O?-?IE ? OA-?IE aeinoia??ii c?inoaa
a?aeiia?aeii ia 19,8% ? 16,4%, aeinoia??ii? aeeiai?ee iieacieea EA-?IE
ia aoei aeyaeaii. Oaeei /eiii, i??ai?noei aeoea?co? i?ioeane o?a?eiie?co
o oeaieiao eii’thieoeae ? oai?eo ia OE, ui cae?enith?oueny iiina?aaeiaii
/a?ac e?ioioeeoa?io nenoaio (ca?eueoo?oueny aeni?an?y e?ioioeeoaie
?aoeaioi??a aei aeoeaaoi??a ieaci?iiaaio).

Aeey i?aeoaa?aeaeaiiy aeyaeaiiai iaoai?cio ae?? i??ai?noeio aecia/aee
o?a?eiie?oe/io aeoeai?noue ne?cii? ??aeeie o oai?eo ia OE, cia/aiiy yei?
caieueooaaeiny ia 9,1%, ii??aiyii c oai?eie ia OE, ye? ia io?eioaaee
i??ai?noei o eiiieaeniiio e?eoaaii?.

Iaie aoei ?ic?iaeaii iiaee niin?a e?eoaaiiy oai?eo ia OE (i??i?eoaoia
aeia?aeea ia aeiao?ae ?99031218). A iniiao aeiaoiaeo aoea iinoaaeaia
caaea/a aaeineiiaeaiiy niiniao e?eoaaiiy OE. O eii’thieoeaaeueio
ii?iaeieio ii?yae c nio?aaeaenii, yeee i?noeoue aeaa aioea?ioeee
(nio?ai?oeei ? a?ai?oeeaeei) ? ei?oeeinoa?i?ae (aeaenaiaoacii)
aeiaeaoeiai ? iaeii/anii caeaiothoue i?aia?ao i??ii?noei. I?e oeueiio
nio?ai?oeei ? a?ai?oeeaeei, aoaeo/e aioea?ioeeaie oe?ieiai niaeo?o,
aieeaathoue ia i?e?iaio oei?o. I??ai?noei aeyaey? aeiaeaoeiao
aioenaioe/io ae?th ia a?eae, a??one, iaei?ino?o?. Aeaenaiaoacii, aoaeo/e
niieo/iith eaieith i?ae o?ueiia aioeaaeoa??aeueieie i?aia?aoaie, ni?ey?
i?aeaeuaiith i?iieeiino? ee?oeiieo iaia?ai caoaeiee?a on?o oei?a,
caaacia/oth/e iaeiie/aiiy a?eueo aeniei? eiioeaio?aoe?? aioea?ioeea ?
i??ai?noeio, i?aeneethth/e aioenaioe/iee aoaeo. Aeiaeaoeiaa
i?ioecaiaeueia ae?y aeaenaiaoaciio i?iyaey?oueny a ina?aaeeo caiaeaiiy
ciaioaiiyi aenoaeaoe??, ciyooyi iaa?yeo. I??ai?noei, iath/e
?ioiiiiaeaethth/? oa aeyaeai? iaie o?a?eiie?oe/i? yeino?, ni?ey?
?icniieooaaiith «o?a?eiiaiai aa?’??o» i a?eueo oaeaeeiio ?ic??oaiith
caiaeaiiy.

Aeey aecia/aiiy aoaeoeaiino? e?eoaaiiy an? oai?? aoee ?iciiae?eai? ia
o?e a?oie. Ca a?eiaeie o?eaae?noth caoai?thaaiiy, a oaeiae ee?i?/ieie
i?iyaaie OE ii??aithaai? a?oie aoee ?aeaioe/ieie:

I a?oio neeaa 91 oai?ee (182 iea), yeee io?eioaaa e?eoaaiiy
?inoeeyoe?yie nio?aaeaeno.

II a?oio neeaee 32 oai?eo (64 iea), ye? io?eioaaee e?eoaaiiy oeyoii
?inoeeyoe?? 0,01% ?ic/eio i??ai?noeio.

III a?oio neeaee 65 oai?eo (130 i/ae), ye? io?eioaaee e?eoaaiiy
?ic?iaeaiei niiniaii ?inoeeyoe?yie i??ai?noeio ? nio?aaeaeno.

I?i aoaeoeai?noue e?eoaaiiy noaeeee ii o?eaaeino? caaino?aiiy,
o?eaaeino? ia??iaeo ?ai?n??, /eneo ui??/ieo ?aoeeaeea?a ? iayaiino?
ee?i?/iiai iaeoaeaiiy. Caeaaei?noue o?eaaeino? caaino?aiiy a?ae
i?iaaaeaiiai e?eoaaiiy oai?eo ia OE cia?aaeaia o oaae.1.

Oaaeeoey 1

Caeaaei?noue o?eaaeino? caaino?aiiy a?ae i?iaaaeaiiai e?eoaaiiy oai?eo
ia OE

Oai?? ia OE

n = 188(376 iea) Canoiniaoaaia O?eaae?noue e?eoaaiiy,

e?eoaaiiy (?inoeeyoe??) O?eaaeinoue eieoaaiiy, na?. no.iieaciee. (aei?)
(I(m; p, p1)

I a?oia n = 91

(182 iea) nio?aaeaen 32,6(3,9

II a?oia n = 32

(64 iea) i??ai?noei 27,2(3,1

p<0,01 III a?oiia n = 65 (130 i/ae) i??ai?noei ? nio?aaeaen 22,8(2,5 p<0,01; p1<0,01 I?ei?oea: 1. ? - a??ia?aei?noue ??cieoe? ii??aiyii c I a?oiith oai?eo, ye? io?eioaaee o?eueee ?inoeeyoe?? nio?aaeaeno; 2. ?1 - a??ia?aei?noue ??cieoe? iiae II i III a?oiaie oai?eo. A ?acoeueoao? aeine?aeaeaiue aeyaeaii (oaae. 1), ui iaeei?iooee ia??iae (22,8 + 2,5 aeiy) caaino?aiiy a?aecia/aiee o oai?eo III a?oie, ye? io?eioaaee ii?aeiai? ?inoeeyoe?? nio?aaeaeno ? i??ai?noeio, ui ia 30,3% ei?iooa, i?ae o oai?eo, yeeo e?eoaaee nio?aaeaenii, oa ia 16,6 % ei?iooa, iiae o oai?eo, yeeo eieoaaee oieueee ii?aiinoeiii. Caeaaei?noue /enea ui??/ieo ?aoeeaeea?a a?ae i?iaaaeaiiai e?eoaaiiy o oai?eo ia OE i?aaenoaaeaia a oaae. 2. Oaaeeoey 2 Caeaaei?noue /enea ui??/ieo ?aoeeaeea?a a?ae i?iaaaeaiiai e?eoaaiiy o oai?eo ia OE Oai?? ia OE (376 iea) Canoiniaoaaia n=188 e?eoaaiiy (?inoeeyoe??) *enei ui??/ieo ?aoeeaeea?a, na?. no. iieaciee (?ac?a) I a?oiia n = 91 n=91 (182 iea) nio?aaeaen 3,1(0,2 – II a?oiia n = 32 (64 iea) i??ai?noei 2,7(0,2 p<0,05 III a?oiia n = 65 (130 i/ae) i??ai?noei ? nio?aaeaen 2,4(0,2 ?<0,01; ?1>0,05

I?ei?oea:

1. ? — a??ia?aei?noue ??cieoe? ii??aiyii c I a?oiith oai?eo, ye?
io?eioaaee o?eueee ?inoeeyoe?? nio?aaeaeno;

2. ?1 — a??ia?aei?noue ??cieoe? iiae II i III a?oiaie oai?eo.

I?iaaaeai? aeine?aeaeaiiy iieacaee (oaae.2), ui /enei ui??/ieo
?aoeeaeea?a o oai?eo III a?oie, ye? io?eioaaee e?eoaaiiy oeyoii
?inoeeyoe?? nio?aaeaeno ? i??ai?noeio neeaei anueiai 2,4 + 0,2
?aoeeaeeaa ia ??e, ui ia 22,6% iaioa ii??aiyii c oai?eie I a?oie ? ia
11,2% — ii??aiyii c oai?eie II a?oie, ai?iaiaeii? ?icieoei /enea
ui?i/ieo ?aoeeaeeaia iiae oai?eie III a?oie, yeo eieoaaee ii?aiinoeiii i
nio?aaeaenii, ia aeyaeaii.

Caeaaei?noue o?eaaeinoi ia??iaeo ?ai?n?? a?ae i?iaaaeaiiai e?eoaaiiy o
oai?eo ia OE cia?aaeaia o oaae. 3.

Oaaeeoey 3

Caeaaei?noue ia??iaeo ?ai?n?? a?ae i?iaaaeaiiai e?eoaaiiy o oai?eo ia OE

Oai?? ia OE

n = 188 (376 iea) Canoiniaoaaia e?eoaaiiy (?inoeeyoe??) O?eaae?noue
ia??iaeo ?ai?n??, na?. no.

iieaciee (i?nyoeue)

I a?oiia n = 91 (182 iea) nio?aaeaen 4,2(0,3

II a?oiia n = 32 (64 iea) i??ai?noei 5,2(0,6

p<0,05 III a?oiia n = 65 (130 i/ae) i??ai?noei ? nio?aaeaen 6,1(0,7 ?<0,01; ?1<0,05 I?ei?oea: 1. ?-a??ia?aei?noue ??cieoe? ii??aiyii c I a?oiith oai?eo, ye? io?eioaaee o?eueee ?inoeeyoe?? nio?aaeaeno; 2. ?1 - a??ia?aei?noue ??cieoe? iiae II i III a?oiaie oai?eo. sse aeaeii c oaae. 3, iaea?eueoee ia??iae ?ai?n?? (6,1 + 0,7 i?nyoey) aeyaeaii o oai?eo III a?oie, ui ia 42,5% a?eueoa, i?ae o oai?eo I a?oie, ? ia 17,3% a?eueoa, i?ae o oai?eo II a?oie. A?ae 1-ai aei 3-o ?ie?a (a na?aaeiueiio 1,9 + 0,3 ?ieo) niinoa??aaeiny 154 oai?eo (308 i/ae), ye? io?eioaaee ??ci? aeaee e?eoaaiiy: c I a?oie — 70 oai?eo (140 i/ae), c II — 28 oai?eo (56 i/ae), c III a?oie — 56 oai?eo (112 i/ae). I?e oeueiio o?eueee o oai?eo III a?oie, ye? io?eioaaee e?eoaaiiy ?ic?iaeaiei iaie niiniaii, iinoeeyoeiyie (i??ai?noei, nio?aaeaen) ca?a?no?iaaia a?aenooi?noue ?aoeeaeea?a caoai?thaaiiy i?ioyaii 1-ai ?ieo niinoa?aaeaiiy o 11 oai?eo (22 iea), a i?ioyaii 2-io ?ie?a niinoa?aaeaiue — o 8 oai?eo (16 i/ae), ui aeicaiey? c?iaeoe caeeth/aiiy i?i ?o ee?i?/ia iaeoaeaiiy, i neeaaea? 33,9% a?ae oai?eo, ye? io?eiaee e?eoaaiiy cai?iiiiiaaiei niiniaii. O ?ioeo a?oiao i?iaeiaaeoaaee a?aei?/aoe ?aoeeaeeae OE ? ee?i?/iiai iaeoaeaiiy ia aeyaeaii a aeiaeiiio aeiaaeeo. Aeniiaee 1. I?iaeaia e?eoaaiiy oai?eo ia o?ii?/iee eii’thieoea?o aei oaia? ia ciaeoea naiai iiaiiai ?ica’ycaiiy, o ca’yceo c a?aenooi?noth iaoeiaeo aeaieo i?i iniaeeaino? ii?ooaiue o nenoai? aaiinoaco, ?ioi?oaoo, ?o aca?iica’yceo a ina?aaeeo caiaeaiiy, a?aenooi?noth iaoiaaiaoe/ii i???ioiaaii? ei?aeoe?? oeeo ii?ooaiue ? iecueei? aoaeoeaiino? ?nioth/eo iaoiae?a e?eoaaiiy. 2. Anoaiiaeaii, ui o oai?eo ia o?ii?/i? eii’thieoea?oe aeyaeaia ??cea ia?aaaaa ?aa?iia?ieo (oeaieia eii’thieoeae) c?ooaiue aaiieiaaoeyoe?? ? o?a?eiie?co iaae nenoaiieie, i?e/iio i?ioeane aaiieiaaoeyoe?? ? o?a?eiie?co o oeaieiao eii’thieoeae o oai?eo ia OE i?aeaeuai?, aea o?a?eiie?c ia “a??aiiaaaeo?” i?ioeane aaiieiaaoeyoe??, ui ia? aaaeeeaa cia/aiiy o ?icaeoeo o?iii/iiai caiaeaiiy o eii'thieoeai. 3. Eii’thieoeaa oai?eo ia OE ia? ?ioiiaeoeai? aeanoeaino?, ye? i?eai?/othoue ooieoe?iiaeueio aeoeai?noue e?ioioeeo?a ? iiiioeeo?a i iineeththoue oaaioeeoa?io aeoeai?noue iaeo?io?e?a, ui aaaea aei ooieoe?iiaeueiiai ii?ooaiiy ee?oeiii? eaiee ?ioi?oaoo o oeeo oai?eo. 4. Anoaiiaeaii, ui cieaeaiiy ooieoeiiiaeueii? aeoeaiinoi iioiieiiiaoaioieo eeioei iaoiiaeth? iaaeinoaoiie ?iaaiue i?ioeania oia?eiieico o oeaieiao eii'thieoeae o oai?eo ia OE. 5. Aeyaeaia caeaoi?noue i?aia?aoo i??ai?noeio aeoea?coaaoe i?ioeane o?a?eiie?co a ina?aaeeo caiaeaiiy o oai?eo ia o?ii?/i? eii’thieoea?oe. 6. ?ic?iaeaiee iiaee niinia e?eoaaiiy oai?eo ia OE oeyoii ?inoeeyoe?e o eii’thieoeaaeueio ii?iaeieio 0,01% ?ic/eio i??ai?noeio ? nio?aaeaeno, yeee caaacia/o? a?eueo ae?aaeaiee aioenaioe/iee, ?ioiiiiaeaethth/ee ? o?a?eiie?oe/iee aoaeoe. Aeiaaaeaia eiai ee?i?/ia aoaeoeai?noue: ia??iae caaino?aiiy nei?ioeany ia 30,1%, ciaioeeinue /enei ui??/ieo ?aoeeaeea?a o 1,8 ?ace, ca?eueoeany ia??iae ee?i?/ii? ?ai?n?? ia 31%, a o 33,9% aeiaaee?a i?ioyaii 1-2-io ?ie?a aeinyaiooi ee?i?/ia iaeoaeaiiy. NIENIE i?aoeue iioae?eiaaieo ca oaiith aeena?oaoe?? 1. Eaaiiaa I.A. Aeoeaiinoue nenoaiiuo e ?aaeiia?iuo (oeaiue eiiuthieoeau) oaeoi?ia aaiieiaaoeyoeee e oea?eiieeca o aieueiuo ino?ui e o?iie/aneei eiiuthieoeaeoii // Iooaeueiie.aeo?i. — 1998. — ? 3. — N. 225-229. 2. Eaaiiaa I.A. Eiioiiaeoeaiua naienoaa eiiuthieoeau i?e ino?ii e o?iie/aneii eiiuthieoeaeoao. // Iooaeueiie. aeo?i. — 1998. — ? 4. — N. 312—315. 3. Eaaiiaa I.A., E?eaioaei TH.N. Iaoioeceieiae/aneia iainiiaaiea i?eiaiaiey ie?aienoeia aeey ei??aeoeee oea?eiieeoe/aneiai iioaioeeaea o aieueiuo o?iie/aneeie eiiuthieoeaeoaie // A?niee iaoeiaeo aeine?aeaeaiue. — 1998. — ? 5-6. — N. 24-26. 4. Eaaiiaa I.A. ?ieue eciaiaiee nenoaiiiai e ?aaeiia?iiai (oeaiue eiiuthieoeau) aaiinoaca a iaoiaaiaca o?iie/aneeo eiiuthieoeaeoia // O?oaeu E?uineiai iaae. einoeoooa ei. N.E.Aai?aeaaneiai, 1997. — O. 133, — *.1. — N. 85-89. 5. Eaaiiaa I.A. Aeeyiea ie?aienoeia ia yeni?anneth eeioioeeoaie ?aoeaioi?ia e aeoeaaoi?ai ieacieiiaaia o aieueiuo o?iie/aneei ianiaoeeoe/aneei eiiuthieoeaeoii // Oac.aeiee. Iaaeaeoia?. eiio., iinayuaiiie 90-eaoeth aeaae. I.A.Io/eianeie. — Iaeanna. — 1988. — N. 402-403. 6.Ivaiiva N., Aibaiva N. Funntiinal antivity if lymphocytic and mininotic - ?haginotin sustems if immunity in ?atients with anute aid nhronic niijunctivitis // ?ain. XXVIII International niigaass if ophthalmology. — Amsterdam (Netherlands). — 1998. — ?. 123. 7. Eaaiiaa I.A. Ia?ooaiea eiioiiie ?aaoeyoeee aaiieiaaoeyoeee o aieueiuo o?iie/aneei ianiaoeeoe/aneei eiiuthieoeaeoii // Oac. aeii. IV Iaaeaeoia?. eiia?anno “Eiioii?aaaeeeoaoeey e ?aaaeeeoaoeey a iaaeeoeeia”: International journal on immunorehabilitation. — Ni/e. — 1998. — ?8. — ?. 145. 8. Eaaiiaa I.A., Aia?iaa I.O. Yooaeoeaiinoue ianoiiai i?eiaiaiey ie?aienoeia aeey ei??aeoeee oea?eiieeoe/aneiai iioaioeeaea o aieueiuo o?iie/aneeie eiiuthieoeaeoaie // O?oaeu IV Iaaeaeoia?. eiio. iooaeueiieiaia. — Eeaa. — 1998. — N. 124-125. 9. Eaaiiaa I.A., Eeoaeiaiei A.A., A?eoei O.A. Ia?niaeoeau eniieueciaaiey IAA-ie?aienoeia a eiiieaeniii ea/aiee, i?iieeathueo ?aiaiee aeaca. // Na. iao/.o?. E?ui iaae. oieaa?neoaoa – O. 132. – 1996 /.1 N.295–296. AIIOAOeIss Iaaiiaa I. A. Iaoiaaiaoe/ia iaa?oiooaaiiy canoinoaaiiy i?aia?aoo ii?aiinoeio i?e eieoaaiii o?iii/ieo eii’thieoeaioia. — ?oeiien. Aeena?oaoeiy ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoeiaeueiinoth 14.01.18 — i/ii oai?iae. — Iinoeooo i/ieo oai?ia i oeaieiii? oa?aii? ii. A.I. Oieaoiaa AII Oe?a?ie, Iaeana, 1999. Ia caoeno aeiineoueny ?oeiien, yeee iinoeoue ?acoeueoaoe eiiieaeniiai aeineiaeaeaiiy nenoaiiiai i iinoeaaiai (oeaieia eii’thieoeae) aaiinoaco, aca?iica’yceo nenoai aaiinoaco oa iioiioaoo, ooieoe?iiaeueii? aeoeaiinoi iioiieiiiaoaioieo eeioei i oaeoi?ia ianiaoeeoi/iiai caoenoo o oai?eo ia aino?i i o?iii/ii eii’thieoeaioe. Anoaiiaeaia ia?aaaaa i?ioeania aaiieiaaoeyoei? a oeaieiao eii’thieoeae iaae oia?eiieicii, ui ia? aaaeeeaa cia/aiiy a iaoiaaiaci o?iii/ieo eii’thieoeaioia. Aeineiaeaeaii aieea ii?aiinoeio ia i?ioeane oia?eiieico a oeaieiao eii’thieoeae i i?eaaaeaii iaoiaaiaoe/ia iaa?oiooaaiiy aoaeoeaiinoi eiai canoinoaaiiy i?e eieoaaiii oai?eo ia o?iii/ii eii’thieoeaioe. ?ic?iaeaiee niinia eieoaaiiy o aeaeyaei ii?aeiaieo iinoeeyoeie ii?aiinoeio i nio?aaeaeno iieiioo? yeinoue eieoaaiiy oai?eo ia o?iii/ii eii’thieoeaioe: nei?i/o? no?iee eieoaaiiy, ciaioo? /enei ui?i/ieo ?aoeeaeeaia, caieueoo? ia?iiae eeiii/ii? ?aiini?, aeicaiey? aeinyaoe eeiii/iiai iaeoaeaiiy o 33,9% oai?eo, ui iiaeoaa?aeaeo? eiai eeiii/io aoaeoeaiinoue. Eeth/iai neiaa: iaoiaaiac, o?iii/iee eii’thieoeaio, ii?aiinoei. AIIIOAOeEss Eaaiiaa I. A. Iaoiaaiaoe/aneia iainiiaaiea i?eiaiaiey i?aia?aoa ie?aienoeia i?e ea/aiee o?iie/aneeo eiiuethieoeaeoia. — ?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.18 — aeaciua aieacie — Einoeooo aeaciuo aieaciae e oeaiaaie oa?aiee ei. A.I.Oeeaoiaa AII Oe?aeiu, Iaeanna, 1999. Caueuaaony ?oeiienue, eioi?ay niaea?aeeo ?acoeueoaou eiiieaeniiai enneaaeiaaiey nenoaiiiai e ianoiiai (oeaiue eiiuethieoeau) aaiinoaca, acaeiinayce nenoaiu aaiinoaca e eiioieoaoa, ooieoeeiiaeueiie aeoeaiinoe eiioiiieiiiaoaioiuo eeaoie e oaeoi?ia ianiaoeeoe/aneie caueou o aieueiuo ino?uie e o?iie/aneeie eiiuethieoeaeoaie. O aieueiuo o?iie/aneeie eiiuethieoeaeoaie (OE) a nenoaiiii e?iaioiea i?e enneaaeiaaiee aaiinoaca auyaeaii ia?ooaiea O oacu naa?ouaaiey e?iae — oacu ia?aciaaiey oea?eia, i /ai naeaeaoaeuenoaotho iiauoaiea aa?aaaoeeiiiie aeoeaiinoe o?iiaioeeoia e aeia?oea?eiiaaiaiey, nio?aiythueany e a ia?eiae ?aiennee caaieaaaiey. Auyaeaii ?aceia i?aiaeaaeaiea ?aaeiia?iuo (oeaiue eiiuthieoeau) naeaeaia aaiieiaaoeyoeee e oea?eiieeca iaae nenoaiiuie. O aieueiuo OE i?ioeannu aaiieiaaoeyoeee e oea?eiieeca a oeaiyo eiiuthieoeau iiauoaiu, ii oea?eiieec ia “o?aaiiaaoeaaao” i?ioeannia aaiieiaaoeyoeee, /oi nio?aiyaony e a ia?eiae eeeie/aneie ?aiennee caaieaaaiey e eiaao iaoiaaiaoe/aneoth iai?aaeaiiinoue. Eiiuthieoeaa aieueiuo OE iaeaaeaao eiioiiiaeoeaiuie naienoaaie, aeiee?othueie ooieoeeiiaeueioth aeoeaiinoue eeioioeeoia, iiiioeeoia e iioaioeee?othueie oaaioeeoa?ioth aeoeaiinoue iaeo?ioeeia. Auyaeaiiua eciaiaiey aaaeoo e ooieoeeiiaeueiiio ia?ooaieth eeaoi/iiai caaia eiioieoaoa e eiatho aaaeiia cia/aiea a iaoiaaiaca OE. Aaaeiui caaiii iaoiaaiaca OE yaeyaony auyaeaiiia iaie ia?ooaiea acaeiiaeaenoaey eiioiiie nenoaiu e nenoaiu aaiinoaca: niaea?aeaiea o?iiaeiiiceoeaiuo eeioioeeoia iiauoaii, a niaea?aeaiea eeioioeeoia, eiathueo ?aoeaioi?u e aeoeaaoi?ai ieacieiiaaia (o?ieeiaciiai, oeaiaaiai e e?iayiiai oeiia) ?acei nieaeaii, /oi a oeaeii niinianoaoao nieaeaieth i?ioeannia oea?eiieeca a oeaiyo eiiuthieoeau o aieueiuo OE. Iineaaeiaa naeaeaoaeuenoaoao i i?eioeeieaeueiie aiciiaeiinoe iiin?aaeiaaiiiai (/a?ac nenoaio eeaoi/iiai eiioieoaoa) aicaeaenoaey ia ianoiua oea?eiieeoe/aneea i?ioeannu. Enneaaeiaaii aeeyiea iiaiai iiaa?oiinoii-aeoeaiiai aauanoaa ie?aienoeia ia i?ioeannu oea?eiieeca a oeaiyo eiiuthieoeau. Onoaiiaeaii, /oi ie?aienoei, ia?yaeo n ecaanoiuie aioeiee?iaiuie e eiioiiiiaeaee?othueie naienoaaie, iaeaaeaao niiniaiinoueth aeoeaece?iaaoue i?ioeannu oea?eiieeca a oeaiyo eiiuthieoeau o aieueiuo OE, aicaeaenoaea i?e yoii inouanoaeyaony iiin?aaeiaaiii /a?ac nenoaio eeaoi/iiai eiioieoaoa. I?iaaaeaiiua eeeie/aneea enneaaeiaaiey iiaeoaa?aeeee yooaeoeaiinoue i?eiaiaiey ie?aienoeia aeey ea/aiey aieueiuo OE, ii iaeaieaa yooaeoeaiui ieacaeinue eiiieaeniia ea/aiea ni/aoaiey ie?aienoeia n nio?aaeaenii. A ?acoeueoaoa ?ac?aaioaiiiai iaie niiniaa ea/aiey aieueiuo OE iooai einoeeeyoeee ie?aienoeia a ni/aoaiee n nio?aaeaenii (i?ei?eoaoiay ni?aaea ? 99031218) ia 30,1% nie?aoeeny n?ie ea/aiey aieueiuo, a 1,8 ?aca oiaiueoeeinue /enei aaeaaiaeiuo ?aoeeaeeaia e ia 31% oaaee/eeny ia?eiae eeeie/aneie ?aiennee; a 33,9% neo/aaa a oa/aiea 1-2-o eao aeinoeaiooi eeeie/aneia aucaei?iaeaiea, /oi ia iaaethaeaeinue i?e ae?oaeo niiniaao ea/aiey OE. Eeth/aaua neiaa: iaoiaaiac, o?iie/aneee eiiuthieoeaeo, ie?aienoei. ANNOTATION Ivanova N.V. Pathogenetic substantiation of the preparation myramistin use in the treatment of chronic conjunctivitis. - Manuscript. The dissertation which contains the results of complex investigation of systemic and local (conjunctiva tissue) hemostasis, correlation of hemostasis system and immunity, functional activity of immunocompetent cells and unspecific defence factors in patients with acute and chronic conjunctivitis is defended. It was determined the prevalence of hemocoagulation processes in conjunctiva tissues aver fibrinolysis, that has great significance in pathogenesis of chronic conjunctivitis. There was ininvestigated the influence of myramistin on the fibrinolysis processes in conjunctiva tissues and given pathogenic substantiation of the effectiveness of its use in the treatment of patients with chronic conjunctivitis. Developed method of treatment by combined instillations of myramistin and sofradex improves the quality of treating the patients with chronic conjunctivitis: shortens the time of treatment, decreases the number of annual reccurences, increases the period of clinical remission, allows to reach the clinical recovery in 35,9% of patients, that confirms its clinical effectiveness. Key words: pathogenesis, chronic conjunctivitis, myramistin. Aaoi? aeena?oaoeieii? ?iaioe aeneiaeth? aeeaieo iiaeyeo aeieoi?o iaaee/ieo iaoe, i?ioani?o, eao?aaoo Aea?aeaaii? i?aii? O?N? caaiaeoth/iio eaoaae?e iie?iaiieiai? oa iioiieiai? E?einueeiai iaaee/iiai oiiaa?neoaoo E?eaioa?io TH?ith Naiaiiae/o ca aaeeeo eiinoeueoaoeaio oa i?aeoe/io aeiiiiiao o iiaeaioiaoei oa aeeiiaiii aeena?oaoei?. PAGE 15

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