Особливості показників кісткового метаболізму і їх корекція у жінок перименопаузального віку після двосторонньої оваріектомії (експериментально-клініч

3

I?I?NOA?NOAI IOI?IIE CAeI?IAss OE?A?IE

IAeANUeEEE AeA?AEAAIEE IAAeE*IEE OI?AA?NEOAO

A?eai??aa Iaoae?y A?eoi??aia

OAeE:
616.71-007.234:618.11-089.87.

INIAEEAINO? IIEACIEE?A E?NOEIAIAI IAOAAIE?CIO

? ?O EI?AEOe?ss O AE?IIE IA?EIAIIIAOCAEUeIIAI A?EO I?NEss

AeAINOI?IIIUeI? IAA??AEOII??

(AENIA?EIAIOAEUeII-EE?I?*IA AeINE?AeAEAIIss)

14.01.01- aeooa?noai oa a?iaeieia?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Iaeana-1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Iaeanueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

I?i?noa?noaa ioi?iie caei?ia’y Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani?

Iaai?ia A?eoi??y
Oaaei??aia,

Iaeanueeee aea?aeaaiee
iaaee/iee oi?aa?neoao,

i?ioani? eaoaae?e
aeooa?noaa oa a?iaeieia??

Io?oe?ei? iiiiaioe: /eai-ei?aniiiaeaio IAI ? AII Oe?a?ie,

aeieoi? iaaee/ieo iaoe,
i?ioani?

Niaiaie?anueea Aaeeia
Einoyioei?aia,

Iaoe?iiaeueiee
iaaee/iee oi?aa?neoao

?i.
I.I.Aiaiiieueoey, i?ioani? eaoaae?e

aeooa?noaa oa
a?iaeieia?? ?1.

aeieoi?
iaaee/ieo iaoe, i?ioani?

Cae?inueeee
Ieaenaiae? Ieaen?eiae/,

Iaeanueeee
aea?aeaaiee iaaee/iee oi?aa?neoao,

caa?aeoaa/
eaoaae?e ia?eiaoaeueii? iaaeeoeeie,

aeeoy/i? oa
i?aee?oeiai? a?iaeieia??

I?ia?aeia onoaiiaa: Euea?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao

?i. Ae.Aaeeoeueeiai,
eaoaae?a aeooa?noaa oa

a?iaeieia?? oaeoeueoaoo
i?neyaeeieiiii? ina?oe

e?ea??a oa i?ia?ci??a, IIC
Oe?a?ie, i.Euea?a.

Caoeno a?aeaoaeaoueny 25 a?oaeiy 1998?. i 13-00 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae.41.600.01 i?e Iaeanueeiio aea?aeaaiiio
iaaee/iiio oi?aa?neoao? (270026, i.Iaeana, i?ia. Aae?oianueeee 2).

C aeena?oaoe??th iiaeia iciaeiieoenue a a?ae?ioaoe? Iaeanueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (270026, i.Iaeana, i?ia.
Aae?oianueeee 3).

Aaoi?aoa?ao ?ic?neaiee 23 eenoiiaaea 1998?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee,

e.i.i., aeioeaio
?iaeeianueea I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. Ooieoe?y y?/iee?a c a?eii ci?ith?oueny, iaeiae
iiai?noth ia caana?. Anoaiiaeaii, ui iaa?oue i?e o?eaae?e iinoiaiiiaoc?
a y?/ieeao ia coieiy-?oueny iiai?noth i?ioean aeic??aaiiy oie?eoe?a, ?
oi/a aiie a oeueiio ia??iae? aeeooy ae?iee ia aeinyaathoue iiaii?
c??eino?, a i?aai?ci i?iaeiaaeo? aacia?a?aii iinooiaoe iaaia e?euee?noue
ano?iaai?a. E??i oiai, aeyaeaii, ui iaa?oue a i?ciueiio
iinoiaiiiao-caeueiiio ia??iae? y?/ieee nae?aoothoue oaeiae ? aiae?iaaie,
ye? ? aeaea?aeii ooai?aiiy ano?iaai?a ? i?iyaeythoue aiaaie?/io ae?th.

Ano?iaaie aieeaathoue ia ??ci? i?aaie oa oeaieie oeyoii aca?iiae?? c?
niaoeeo?/-ieie ?aoeaioi?aie, eio?? aeyaeai?, e??i iaoee oa iiei/ieo
caeic, a e?noeao, o?ao??, na/iaiio i?oo??, ee?oeiao i?oae, iycao
oaciaiai aeia, ee?oeiao iiceo, na?oey oa a?oa-??e, oe??e, neeciaeo
iaieiieao ?ioiai? ii?iaeieie, ai?oai?, eiithieoeae (Niao- iee A.I.,
1997). Ia oii? a?eiaiai /e yo?iaaiiiai aeao?oeeoo ano?iaai?a iiaeooue
aeie-eaoe caoai?thaaiiy cacia/aieo i?aai?a. Ca oa?aeoa?ii i?iya?a oa
/anii aeyaeaiiy oe? iaoieia?/i? noaie iiaeia ?iciiae?eeoe ia ?aii?
(aaciiioi?i?, ineoiaiioe?ei?), na?aaeiuei/ania? (o?iaai?oaeuei?, oe??i?)
oa i?ci? (inoaiii?ic oa na?oeaai-noaeeii? caoai?thaaiiy). C /anii
aaciiioi?i? oa ineoiaiioe?ei? ii?ooaiiy o a?eueoino? oai?eo caciathoue
cai?ioiueiai ?icaeoeo, oiae? ye iai?iii-aiaeie?eiiee eiiieaen iaooeeueii
i?ia?ano? (Aeoey?aa E.I.,1997?.; Niaoiee A.I.,1997?.; Oaoa?/oe O.O.,
1997). E??i oiai, aaaeeeai cacia/eoe, ui yeui ?aii? oa na?aaeiuei/ania?
i?iyae cieaeothoue ye?noue aeeooy ae?iee, oi i?ci? — aaciina?aaeiuei
caa?iaeothoue eiio.

A ia?e- oa iinoiaiiiaocaeueiiio a?oe? /anoi aeieeathoue iooeeie iaoee oa
y?/ie-e?a, ui iio?aaothoue ?aaeeeaeueieo o??o?a?/ieo ao?o/aiue, ye?,
i/aaeaeii, i?enei?ththoue i?ia?anoaaiiy iai?ii-aiaeie?eiieo i?iya?a, ?,
cie?aia, ianoaiiy inoaiii?ico.

Inoaiii?ic — caoai?thaaiiy, yea oa?aeoa?eco?oueny cieaeaiiyi u?eueiino?
e?noei-ai? oeaieie, a ?acoeueoao? /iai c?inoa? ?ecee ? /anoioa ia?aeii?a
??cii? eieae?caoe?? (o?e o?aaoe?a, aeenoaeueiiai a?aeae?eo i?iiaiaai?
e?noee, oeeee noaaiiai? e?noee), nen-oaiieo ia?aeii?a (Iiai?icithe A.A.,
1995?.). A inoaii? ?iee ia Oe?a?i? ii/aee i?i-aiaeeoenue aeine?aeaeaiiy,
ye? noinothoueny a?eiai? no?oeoo?e ia?aeii?a oa e?eueeino? eth-aeae c
inoaiii?icii, oi/a ia nueiaiaei?oi?e aeaiue inoaoi/ii ia aecia/ai?
nioe?aeueii-aeiiii?/i? aniaeoe iane?aee?a inoaiii?ico aeey iaoi?
aea?aeaae (?.A.Aiaaoe?ueiaa oa ni?aaao.,1997?.; Iiai?icithe A.A.
1997?.). A oeeo oiiaao iaeiei c iaeaaaeeea?oeo caa-aeaiue ? ?aiiy
ae?aaiinoeea oa aecia/aiiy nooiaith oyaeeino? inoaiii?ico a oie /an ye
iniaeea?noth niinoa?aaeaiiy ca oai?eie ia no/aniiio aoai? ? i?ciy
ae?aaiinoeea, eiee cyaeythoueny eiai a??ci? oneeaaeiaiiy — nenoaii?
ao?aaiaoe/i? ia?aeiie. Ine?eueee c iaaee/ii? oa nioe?aeueii-aeiiii?/ii?
iiceoe?e iiia?aaeeoe ao?aoo e?noeiai? oeaieie oa iiaeaeueo? ia?aeiie
eaaoa ? aeaoaaoa, oi iniaeeao oaaao ne?ae i?eae?eyoe ?o i?io?eaeoeoe?.

Iacaaaeath/e ia aaaaoi/enaeuei? aeine?aeaeaiiy, ye? i?enay/ai? aea/aiith
ao?ieia??, iaoiaaiaco, ae?aaiinoeoe? oa e?eoaaiith inoaiii?ico, ? ia
nueiaiaei?oi?e aeaiue oey i?iaeaia caeeoa?oueny a?aee?eoith.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. ?iaioa
aeeiioaaeanue a?aeiia?aeii c ieaiii oai IAe? Iaeanueeiai aea?aeaaiiai
iaaee/iiai oi?aa?neoaoo ”I?iaeaie iaoa?einoaa, aeeoeinoaa ? n?i’? a
no/anieo nioe?aeueii-aeiiii?/ieo oiiaao Oe?a?ie” (? aea?aeaaii?
?aa?no?aoe?? I196 UI189I7,1995-1998?)

Iaoa ? caaea/? aeine?aeaeaiiy. ?ic?iaeoe iaoiaee ?aiiuei? i?io?eaeoeee
inoaiii-?ico o ae?iie ia?eiaiiiaocaeueiiai a?eo i?ney aeainoi?iiiuei?
iaa??aeoii?? ia iniia? aecia/aiiy iieaciee?a e?noeiaiai iaoaaie?cio a
?aiiueiio oa a?aeaeaeaiiio i?ney-iia?aoe?eiiio ia??iae?.

Aeey aeinyaiaiiy iaoe ae??ooaaeenue oae? caaea/?:

1. Aea/eoe a aenia?eiaio? ci?ie eaeueoe??aiai iai?io o uo??a c??eiai
a?eo i?ney o??o?a?/ii? eano?aoe?? oa ei?aeoe?? aeyaeaieo ii?ooaiue.

2. Aea/eoe ee?i?/iee ia?aa?a iinoeano?aoe?eiiai neiae?iio a ?aiiueiio oa
i?ciueiio i?neyiia?aoe?eiiio ia??iae? o ae?iie ee?iaeoa?e/iiai a?eo.

3. Aea/eoe iieacieee ooieoe?? y?/iee?a o ae?iie ia?eiaiiiaocaeueiiai
a?eo.

4. Aecia/eoe iieacieee e?noeiaiai iaoaaie?cio o ae?iie ia?ao?aeiiai a?eo
i?ney aeai-noi?iiiuei? iaa??aeoii?? a ?aiiueiio oa a?aeaeaeaiiio
i?neyiia?aoe?eiiio ia??iae?.

5. ?ic?iaeoe iaoiaee ?aiiuei? i?io?eaeoeee inoaiii?ico o ae?iie
ia?ao?aeiiai a?eo i?ney aeainoi?iiiuei? iaa??aeoii??.

6. Ioe?ieoe aoaeoeai?noue ?ic?iaeaieo iaoiae?a, ai?iaaaeeoe ?o o
i?aeoeeo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a.

§ Aia?oa a aenia?eiaio? anoaiiaeai? ii?ooaiiy e?noeiaiai iaoaaie?cio o
uo??a c??eiai a?eo a ?aiiueiio i?neyiia?aoe?eiiio ia??iae? i?ney
aeaeaeaiiy y?/iee?a.

§ Aecia/ai? a aenia?eiaio? iioeiaeuei? aeice ai?iiiaeueieo i?aia?ao?a
aeey i?io?eaeoeee inoaiii?ico, ui aea? iiaeeea?noue aeey
?iaeea?aeoaeueiiai i?aeoiaeo a ee?i?/i?e i?aeoeoe?.

§ Aia?oa aecia/ai? ?ioi?iaoeai? iieacieee e?noeiaiai iaoaaie?cio naia o
ae?iie ia?eiaiiiaocaeueiiai a?eo i?ney iia?aoeaieo ao?o/aiue, ui
noi?iaiaeaeothoueny aeainoi?iiiueith iaa??aeoii??th c i?eaiaeo
aeia?iye?nieo iooeei aioo??oi?o noaoaaeo i?aai?a, a aeeiai?oe? ia?oiai
?ieo i?ney iia?aoe??.

§ Ae?noaa iiaeaeueoiai ?icaeoeo aiae?c ee?i?ee ?aii?o iciae ii?ooaiue
e?noeiaiai iaoaaie?cio i?e iinoeano?aoe?eiiio neiae?ii? a ia?e- oa
iinoiaiiiaoc?.

§ Aia?oa iaa?oioiaai? i?eioeeie ?aiiuei? i?io?eaeoeee inoaiii?ico o
ae?iie c aeaeaeaieie y?/ieeaie c i?eaiaeo aeia?iye?nieo iooeei
aioo??oi?o aai?oae?e a ia?eiaiiiaoc?.

§ Anoaiiaeaiee /an ii/aoeo ?aiiuei? i?io?eaeoeee oa ae?noaee
iiaeaeueoiai ?icaeoeo iaoiaee iiia?aaeaeaiiy inoaiii?ico o ae?iie
ia?ao?aeiiai a?eo i?ney aeaeaeaiiy y?/iee?a c i?eaiaeo aeia?iye?nieo
iooeei aioo??oi?o noaoaaeo i?aai?a.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a.

§ Aecia/aia ee?i?ea ?aii?o neiioii?a ii?ooaiiy e?noeiaiai iaoaaie?cio
i?e iinoeano?aoe?eiiio neiae?ii?.

§ Aecia/ai? ae?aaiinoe/ii cia/ou? iieacieee noaio e?noeiai? oeaieie o
ae?iie i?ney iaa??aeoii??.

§ Aecia/aia a?oia ?eceeo ii aeieeiaiith inoaiii?ico.

§ ?ic?iaeai? iaoiaee ?aiiuei? i?io?eaeoeee inoaiii?ico o ae?iie
ia?eiaiiiaocaeueiiai a?eo i?ney aeaeaeaiiy y?/iee?a c i?eaiaeo
aeia?iye?nieo iooeei aioo??oi?o aai?oae?e.

Ai?iaaaeaeaiiy ?acoeueoao?a aeine?aeaeaiiy i?iaaaeaii o ?iaioo
a?iaeieia?/iiai a?aeae?eo IEE ?2 i. Iaeane (aeo ai?iaaaeaeaiiy a?ae
22.08.98?.), iieiaiaiai aoaeeieo ?7 i.Iaeane (aeo ai?iaaaeaeaiiy a?ae
03.09.98?.), o ae?ii/eo eiinoeueoaoe?yo ?8 (aeo ai?iaaaeaeaiiy a?ae
01.09.98?.), ?9 (aeo ai?iaaaeaeaiiy a?ae 03.09.98?.), ?10 (aeo
ai?iaaaeaeaiiy a?ae 01.09.98?.) i. Iaeane.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi cae?eniaiee
iaoaioii-?ioi?iaoe?eiee iiooe, iinoaaeai? caaea/? aeine?aeaeaiiy,
aecia/ai? iaoiaee/i? i?aeoiaee, ii?aoeueiaai? iaoiaee, ca?aeii c yeeie
iniaenoi aeeiiai? aenia?eiaioaeuei? oa ee?i?/i? aeine?aeaeaiiy.
I?iaaaeaia noaoenoe/ia ia?iaea iaea?aeaieo ?acoeueoao?a, ioi?ieaiiy ?o o
aeaeyae? oaaeeoeue ? a?ao?e?a, c?iaeaii aiae?c ?acoeueoao?a,
noi?ioeueiaai? aeniiaee ?iaioe, iioae?eiaai? iniiai? iieiaeaiiy
aeena?oaoe??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy aeena?oaoe??
aeiiia?aea-eenue ia I oa II Oe?a?inueeeo eiioa?aioe?yo Inoaiii?ic:
ai?aeai?ieia?y, ee?i?ea, ae?aa-iinoeea, e?eoaaiiy oa i?io?eaeoeea (Ee?a,
1995?., Euea?a, 1997?.), ia O c?cae? aeooa-??a-a?iaeieia?a Oe?a?ie
(Iaeana, 1996?.), iaoeiai-i?aeoe/i?e eiioa?aioe?? Aeooaeuei? i?iaeaie
aa??ao?e/ii? i?oiiaae?? (Ee?a, 1996?.), iaoeiai-i?aeoe/i?e eiioa?aioe??
Iaiiiaoca oa caei?iay ae?iee (Ee?a, 1998?.), ia ?? I?aeia?iaeiiio
iaaee/iiio eiia?an? nooaeaio?a ? iieiaeeo a/aieo (Oa?iii?eue, 1998?.).

Ioae?eaoe??. Ca oaiith ?iaioe iaae?oeiaaii 8 ?ia?o, c ieo 4
noaoo? o iaoeiaeo oaoiaeo aeaeaiiyo oa 3 oace noaooae.

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y i?aaenoaaeaia a iaeiiio
oii?, aeeeaaeaia ia 160 noi??ieao iaoeiiieniiai oaenoo ? neeaaea?oueny
?c anooio, iaeyaeo e?oa?aoo?e, ?icae?eo iienaiiy iaoa??ae?a ? iaoiae?a
aeine?aeaeaiiy, 3 ?icae?e?a ?acoeueoao?a aeanieo aenia?eiaioaeueieo oa
ee?i?/ieo aeine?aeaeaiue, aiae?co oa ocaaaeueiaiiy, aeniiae?a oa
?aeiiaiaeaoe?e, nieneo e?oa?aoo?e. A oaeno? iaaaaeaii 26 oaaeeoeue, 29
?ethno?aoe?e, 11 i?e?ioioia?ao?e. Nienie aeei?enoaii? e?oa?aoo?e
i?noeoue 96 aeaea?ae ia oe?a?inuee?e oa ia ?in?enuee?e iiaao ? 144
?iicaiieo aeaea?ae.

INIIAIEE CI?NO ?IAIOE

Iaoa??ae oa iaoiaee aeine?aeaeaiiy. Ia?eoaie aea/aiiy a aenia?eiaio?
aoee 40 naiie uo??a c??eiai a?eo (12-13 i?n.) e?i?? A?noa?, ?o
a?ieia?/i? noano?aoe (e?ia, oeaieie iaoie, o?aaoe?a). Aeanyoue caei?iaeo
uo??a neeaee eiio?ieueio a?oio, o?eaeoey-oueii aoea aeeiiaia iia?aoe?y a
ia?i? aeainoi?iiiuei? iaa??aeoii?? i?ae ao??iei ia?ei-cii. Aeanyoue
oaa?ei a i?neyiia?aoe?eiiio ia??iae? ia io?eioaaee eiiieaenio oa?ai?th
(a?oia ii??aiyiiy). Aeaaaeoeyoue uo??a i?ney iia?aoe?? io?eiaee
e?eoaaiiy i?aia?aoaie eaeueoe?th oa ano?iaai?a (iniiaia a?oia). A
caeaaeiino? a?ae aeic i?aia?ao?a uo?? aoee ?icae?eai? ia 4 i?aea?oie.
I?aea?oia A io?eioaaea o?eueee eaeueoe?e (7ia/aeiao) o aeaeyae?
aetheiiaoa eaeueoe?th, yeee aaiaeeany oeyoii aiaeiaano?aeueiiai
ciiaeoaaiiy. I?aea?oie A, A oa A ii?yae c eaeueoe??i io?eioaaee
ano?iaai-aanoaaaiiee i?aia?ao o?eea?ea? c iiae?aiei oeyoii aaaaeaiiy. A
neeaae oeueiai i?aia?aoo aoiaeeoue ao?i?eano?aae?ie, yeee aaiaeeany a
e?eoaaeuei?e aeic? 25 iea/ae , a oaeiae a aeicao 19 iea/ae oa 13 iea/ae,
ui a ia?a?aooieo ia aaao uo??a neeaei 0,12 iea/ae, 0,09 iea/ae oa 0,06
iea/ae. Ine?eueee, a na?aaeiueiio o?eaae?noue noaoaaiai oeeeeo o naiie,
ye? a?aenaaeaeai? a?ae naioe?a, neeaaea? 6-7 aei?a, i?aia?aoe
aaiaeeeenue i?ioyaii 6 aei?a c ia?a?aith a 1 aeaiue, e?euee?noth 6
?ac?a. Caa?? iaoa??aeo i?iaiaeeany a e?ioe? aenia?eiaioo, eiai
o?eaae?noue neeaea 7 oeaei?a.

Ia?eo ee?i?/iiai aeine?aeaeaiiy — 136 ae?ioe ee?iaeoa?e/iiai
a?eo, ?o a?ieia?/i? noano?aoe (e?ia, na/a, e?noee eeno?, aeae?eaiiy c
i?oae). Noi aeaaiaaeoeyoue ae?iie ia?a-ianee iia?aoe??, ye?
noi?iaiaeaeoaaeenue aeaeaeaiiyi y?/iee?a c i?eaiaeo aeia?iye?nieo iooeei
iaoee /e y?/iee?a. A?n?iaeanyo aea? c ieo (iniiaia a?oia) io?eioaaee
eiii-eaenio ai?iiiii?io?eaeoeeo iaoo?aeueieie ano?iaai-aanoaaaiieie
eiiieaenaie a ii?aeiaii? c i?aia?aoaie eaeueoe?th, o?eaeoeyoue –ia
io?eioaaee inoaiiuei? (a?oia ii??a-iyiiy). Aeaaaeoeyoue /ioe?e oiiaii
niiaoe/ii caei?iaeo ae?iie c o?ii?/ieie caoai?th-aaiiyie a noaae??
?ai?nn?? oeueiai ae a?eo neeaee eiio?ieueio a?oio. O?eaeoeyoue /ioe?e
ae?iee aoee i?iiia?iaai? a iinoiaiiiaoc? (?? o?eaae?noue neeaea 1-4
?iee), n?iaeanyo a?n?i ae?iie — ia oii? caa?aaeaiiai iaino?oaeueiiai
oeeeeo. Aeey iiaeaeueoiai aiae?co a on?o a?oiao aoei aeae?eaii ii 5
i?aea?oi. ? — ae?iee, i?iiia?iaai? a i?aiaiiiaoc? c iaee??iiyi 2-3
nooiaiy, ?? — i?iiia?iaai? a i?aiaiiiaoc? aac iaaei??ii? aaae o?ea /e c
iaee??iiyi ? nooiaiy, ??? i?aea?oia — iaoe??ioee, i?iiia?iaai? a
iinoiaiiiaoc? c iaae-i??iith aaaith o?ea (iaee??iiy 2-3 no), ?V-
i?iiia?iaai? a iinoiaiiiaoc? c ii?iaeue-iith aaaith o?ea /e iaee??iiyi ?
nooiaiy, V i?aea?oia — ae?iee c aeno?aaai?oaeueiith iaoieia??th, ui
ni?ey? ii?ooaiith iai?io eaeueoe?th a i?aai?ci? (oeoe?iaee ae?aaao,
?aaiaoeci, inoaioiiae?ic, caoai?thaaiiy oeoieiai-eeoeiaiai o?aeoo).

Eiiieaenia e?eoaaiiy a i?neyiia?aoe?eiiio ia??iae? o iaoe??ioie iniiaii?
a?o-ie neeaaeaeiny c oa?iaeioa?ai?? oa ae??oe ? iieyaaei a i?ecia/aii?
iaoo?aeueieo ano-?iaai-aanoaaaiieie eiiieaen?a (ee?iai, ee?iiii?i) oa
i?aia?ao?a eaeueoe?th c 3-4 i?n. i?ney iia?aoe??. A neeaae
aeuacacia/aieo ai?iiiaeueieo i?aia?ao?a aoiaeeoue ano?aae?i-ea aaea??ao
a aeic? 2ia. Cai?nia ai?iiiioa?ai?y i?ecia/aeanue o aacia?a?aiiio
?aaee-i? i?ioyaii 6 i?n. (6 eo?n?a). Iaeei eo?n neeaaeaany c i?eeiio 1
oaae/aeiao i?ioyaii 21 aeiy c 7-aeaiiith ia?a?aith. C i?aia?ao?a
eaeueoe?th aeei?enoiaoaaee aetheiiao eaeue-oe?th o aeic? 2,5-3,5
a/aeiao (5-7 oaae.) i?ioyaii 2-3 oeaei?a c iiaeaeueoei ciaioaiiyi aeice
aei 2a/aeiao i?e iiaeeeaino? aeei?enoaiiy ae??oioa?ai??. E?eoaaeueia
oa?/oaaiiy aeeth/aei niiaeeaaiiy i?iaeoeo?a c aenieei ai?noii
eaeueoe?th, cie?aia, iieiea oa iiei/ii-eeneeo, ?eaieo i?iaeoeo?a, ne??a.

Caa?? iaoa??aeo a ee?i?oe? i?iaiaeeany ca 2 aiae. aei iia?aoe??, /a?ac
24 oa 48 aiae. i?ney ia? (aeey aecia/aiiy aieeao aaciina?aaeiuei
iia?aoeaiiai ao?o/aiiy ia iieacieee, ye? aea/aeenue) oa /a?ac 3-4 ?
9-11 i?n. i?ney aeaeaeaiiy y?/iee?a aeey i?iaaaeaiiy aeine?aeaeaiue o
a?eueo a?aeaeaeaiiio i?neyiia?aoe?eiiio ia??iae? (i?ioyaii ia?oiai ?ieo
i?ney o??o?a?/ii? eano?aoe??).

Aeei?enoiaoaaeenue ne?aeoth/? iaoiaee aeine?aeaeaiiy: ee?i?/i? (ca??
aiaiiaco, ia?eoeaia ianoaaeaiiy); eieueiioeeoieia?/i? aeine?aeaeaiiy
(iaoiae A?enoa E.Ae., 1967); a?io?i?/i?: aecia/aiiy ??aiy eaeueoe?th a
ne?iaaooe? e?ia? oa eiai aeiaiaa aene?aoe?y c na-/ath (iaoiae Bartelmai
W.,1966 (eiei?eiao?e/iee iaoiae), aecia/aiiy a ne?iaaooe? e?ia? ai?noo
oinoi?o (eiei?eiao?e/iee iaoiae), ai?iiiai acioo (iaoiae A.A.Ocaaei-ai?
a iiaeeo?eaoe?? C.N.*oeeiai?, 1976); iieacieea e?euee?niiai
ni?aa?aeiioaiiy eaeue-oe?e / oinoi? a ne?iaaooe? e?ia?; aeoeaiino?
eoaeii? oinoaoace (iaoiae McComb R.B., Bowers G.N., 1979), eieaaaiace
(iaoiae Aurleigh M.,1974), ?cioeeo?aoaeaa?ae?iaaiace (iaoiae Ellis
G.,Goldberg D.M., 1971), ?aae?i?ioiiee iaoiae aeey aecia/aiiy ??aiy
ano-?aae?ieo a ne?iaaooe? e?ia? naiie uo??a; ?ioiioa?iaioiee aiae?c
(aecia/aiiy ??aiy oie?eoeinoeioethth/iai ai?iiio, ano?aae?ieo a
ne?iaaooe? e?ia? ae?iie) (IMx-system, Abbott Laboratories, USA);
a?noieia?/i? (aeine?aeaeaiiy aiaeiiao??th iaoie oa iiia?a-eiaeo o?aaoe?a
uo??a (Oaoea E.,1980).Noaoenoe/io ia?iaeo ?acoeueoao?a i?iaiaee-ee ca
aeiiiiiaith eiiithoa?o ?antium-166 ? iaeaoo noaiaea?oieo i?ia?ai
Microsoft Exel.

?ACOEUeOAOE INIAENOEO AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

Aeai?, io?eiai? a aenia?eiaio?, na?ae/eee i?i oaiaeaioe?th aei cieaeaiiy
??aiy ano?aae?ieo a ne?iaaooe? e?ia? uo??a c??eiai a?eo i?ney
o??o?a?/ii? eano?aoe?? (0,85 0,09ia/ie ii??aiyii c 1,090,09ia/ie,
?<0,05). Io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui ia oii? a?eiaiai cieaeaiiy ooieoe?? aiiaae aeaeaeaiiy y?/iee?a ia aeeeeea? iano?eueee ??ceiai iaae?iiy ??aiy ano?iaai?a, ye oi a ?ai?iaeoeoeaiiio ia??iae?, oi/a aiii ? aeyaey?oueny i?e ?iaeea?aeoaeueiiio aiae?c?. I?ney e?eoaaiiy ??aaiue ano?aae?ieo a e?ia? uo??a aoa aeinoia??ii ieae/ei ca a?aeiia?aeiee, ye a eiio?ie?, oae ? a a?oii? ii??aiyiiy (i?aea?oia A–0,160,035ia/ie, A-0,1060,004ia/e, A-0,0450,004ia/ie, A-0,0280,03ia/ie ii??aiyii c 1,090,09ia/ie a eiio?ie?; ?0,01 aeey an?o i?aea?oi). Aaaeeeai cacia/eoe, ui /ei a?eueoa aoea aeica aeciaaiieo ano?iaai?a, oei iaioei aoa ??aaiue ano?aae?ieo a e?ia?. Io?eiaiee ?acoeueoao na?ae/eoue i?i oa, ui aeice, ye? aaiaeeeenue, aoee iaaei??ieie, ine?eueee a?aeiii, ui cia/i? aeice aeciaaiieo ano?iaai?a i?eaiiaeththoue nae?aoe?th aeanieo. Ca aeaieie eieueiioeeoieia?/iiai aeine?aeaeaiiy ??aaiue iiaa?oiaaeo ee?oei a iac-eao uo??a c a?oie ii??aiyiiy aeinoia??ii ia a?ae??ciyany a?ae oaeiai a eiio?ie?. E??i oiai, aeyaeaii, ui o uo??a i?ney o??o?a?/ii? eano?aoe?? o 70% iace?a aeyaeyeenue eaeeioeeoe a e?eueeino? a?ae 10 aei 50 oa aaeeea e?euee?noue neeco, ui na?ae/eoue i?i oa, ui aiane?aeie ano?iaaiiiai aeao?oeeoo ?icaeaathoueny aeena?ioe/i? i?ioeane a i?oa? c aeiee-iaiiyi eaeeioeeoa?ii? ?io?eueo?aoe??, a iaaeae? iaoieia?? o?iaai?oaeueiiai o?aeoo. Aeai? eieueiioeeoieia?/iiai aeine?aeaeaiiy i?ney e?eoaaiiy ei?aeththoue c iieacieeaie ?aae?i-?ioiiiai aeine?aeaeaiiy ? na?ae/aoue i?i iecueeo iane/ai?noue i?aai?cio ano?iaaiaie. I?ney iia?aoe?? o uo??a aeyaeaii aeinoia??ia cieaeaiiy ai?noo eaeueoe?th a ne?i-aaooe? e?ia? (2,1570,03iiieue/e ii??aiyii c 2,4890,04 iiieue/e, ?0,01). I?ney e?eo-aaiiy ??ai? eaeueoe?th aoee aeinoia??ii aeueie, ii??aiyii c iieacieeaie o iae?eiaa-ieo uo??a (a?aeiia?aeii a i?aea?oiao: A–2,4370,07iiieue/e, A-2,4660,04iiieue/e, A-2,5490,07iiieue/e, A-3,0720,16iiieue/e, ?0,01 aeey an?o i?aea?oi), aeinyaaee ??aiy eiio?ieth a i?aea?oiao A, A oa A oa aeinoia??ii ia?aaeuoaaee eiai a i?aea?oi? A. I/a-aeaeii, aeica ao?i?eano?aae?ieo, yea aeei?enoaia a i?aea?oi? A (0,12iea/ae), a ii?aeiaii? c 7ia/ae aetheiiaoo eaeueoe?th aoea iaaei??iith aeey i?io?eaeoeee aeyaeaieo ii?ooaiue. C /anii i?ney aeaeaeaiiy y?/iee?a a?aeaoaaeinue aeinoia??ia cieaeaiiy aeoeaiino? eoaeii? oinoaoace (189,912,9U/l ii??aiyii c 291,4620,8U/l; ?0,01). I?ney e?eoaaiiy uo??a o?eueee eaeueoe??i aeoeai?noue oa?iaioo a i?aea?oi? A ia a?ae??ciyeanue a?ae oaei? ae a a?oi? ii??aiyiiy (?>0,05),
a i?e aeiaeaoeiaiio i?eeiaii? ano?iaai?a a i?aea?oiao A, A oa A, aiia
aeinoia??ii c?inoaea (a?aeiia?aeii a i?aea?oiao A–21818,1U/l,
A-230,95,2U/l, A-267,512,8U/l, A-2816,4U/l; ?0,01). Io?eiai? ?acoeueoaoe
na?ae/aoue i?i oa, ui iiiioa?ai?y eaeueoe??i o oeueiio a?oe?
iaaeinoaoiuei aoaeoeaia ? iio?aao? aeiiiaiaiiy ai?iiiaeueieie
i?aia?aoaie.

A?aei?/aii a?aenooi?noue ci?i a aeoeaiino? ?cioeeo?aoaeaa?ae?iaaiace a
ne?iaaooe? e?ia? uo??a i?ney iia?aoe??. I?ney e?eoaaiiy o?eueee a
i?aea?oi? A aeyaeaia aeinoia??ia ??cieoey c eiio?ieai oa a?oiith
ii??aiyiiy (?0,01).

Io?eiai? aeai? a?noieia?/iiai aeine?aeaeaiiy na?ae/aoue i?i iayai?noue
inoaiii?ioe/ieo ci?i o uo??a c??eiai a?eo ua aei iia?aoe??, /iio ni?ey?
a?eiaee aeao?oeeo ano?iaai?a. I?ney eano?aoe?? oe? ci?ie iineeththoueny.
A ?acoeueoao? e?eoaaiiy o iia?iaaieo uo??a yaeua iii??ii ae?aaeaii?
inoaiaeeno?io?? ii?aeioaaeenue ?c aeoeaii ieeiieie i?ioeanaie
iiaiooai?aiiy e?noeiai? oeaieie.

O uo??a c eiio?ieth aeyaeaii i?inoo ao?io?th aiaeiiao??th c eiai
nae?aoi?ie-ie ci?iaie a ie?aieo oaa?ei. I?ney iia?aoe?? oaeiae
aeyaeyeanue i?inoa ao?io?y aiaei-iao??th, aea aac iciae nae?aoe??. I?ney
e?eoaaiiy a?ia?ieanoe/ieo ci?i ia ae?aaiinoi-aaii, a on?o i?aia?aoao
aeyaeaia i?inoa ao?io?y aiaeiiao??th c iciaeaie nae?aoe??, ui na?ae/eoue
i?i neaaeo noeioethth/o ae?th aeuacacia/aieo aeic i?aia?ao?a ia
aiaeiiao??e.

Oaeei /eiii, aeaeaeaiiy y?/iee?a o naiie uo??a c??eiai a?eo aaaea aei
?aii?o ci?i e?noeiaiai iaoaaie?cio, a naia, aei cieaeaiiy ??aiy
eaeueoe?th oa eoaeii? oinoaoa-ce, ? aei i?iyao a?noieia?/ieo iciae
inoaiaeeno?io?? aaea /a?ac 6 oeaei?a i?ney iia?aoe??. Iioeiaeueii
aoaeoeaiith aeicith ao?i?eano?aae?ieo aeey ei?aeoe?? eaeueoe??aiai
iai?io i?ney aeainoi?iiiuei? iaa??aeoii?? ? 0,06-0,09 iea/ae aeey uo??a
aaaith 300±20a., ui a 1,5-2 ?ace ieae/a, i?ae aeica, yea, ca aeaieie
e?oa?aoo?e, aeei?enoiao?oueny aeey e?eoaaiiy inoaiii?ico.

A ee?i?/i?e /anoei? ?iaioe i?e ianoaaeaii? ae?iie eiio?ieth oa a?oie
ii??aiyi-iy aei iia?aoe?? ca aeiiiiiaith ?iaeaeno Eoia?iaia a iaio
a?oiao aeyaeaii aaaaoino-aeeii? oa ineoiiaa?ioe/i? i?iyae
ee?iaeoa?e/iiai neiae?iio. O 25% ae?iie eiio?i-eth oa o 23,33%
iaoe??ioie c a?oie ii??aiyiiy ae?aaiinoiaaii ee?iaeoa?e/iee neiae-?ii
eaaeiai nooiaiy aaaeeino?. A?i a?aeiia?aeaa ca ?iaeaenii Eoia?iaia 15-19
aaeai ? oa?aeoa?ecoaaany iayai?noth i?eeea?a (1-4 ?ace i?ioyaii aeiy),
a?ae/oooyi iiacai-iy io?aoie /e ii?i?iiyi, iniaeeai o ae?eyieao aa?oi?o
oa ieaei?o e?ioe?aie, i?aeaeuaiith aoiiethaai?noth oa iiaaiei iano?i?i.
Io?eiai? aeai? na?ae/aoue i?i oa, ui o ianoaaeaieo ae?iie, ye a i?a- oae
? a iinoiaiiiaoc?, aeyaeythoueny aaaaoiiaa?ioe/i? i?iyae ee?iaeoa?e/iiai
neiae?iio. O a?eueoino? iaoe??ioie aiie ia aeinyaathoue naiai iiaiiai
?icaeoeo, oi/ ? iiaeooue aooe i?enooi?, iaeiae i?eaeecii o 25% ae?iie,
ca ?a-coeueoaoaie aeaiiai aeine?aeaeaiiy, aiie iano?eueee ?ioaineai?, ui
oi?iothoue ee?iaeoa-?e/iee neiae?ii. Nea?ae c aieo e?noeiai? nenoaie
aeyaeyeenue o?eueee o ae?iie V i?ae-a?oie eiio?ieth oa a?oie ii??aiyiiy
aei iia?aoe??, a aiaiiac? yeeo aoee caoai?thaaiiy, ui ni?eythoue
ii?ooaiith e?noeiaiai iaoaaie?cio (oeoe?iaee ae?aaao, ?aaiaoeci,
inoaioiiae?ic, caoai?thaaiiy oeoieiai-eeoeiaiai o?aeoo) ?
?icoe?ith-aaeenue, ye i?iyae noiooiuei? aeno?aaai?oaeueii? iaoieia??, ia
iiaycai? c ?icaeoeii i?ci?o, iai?iieo i?iya?a ee?iaeoa??y.

Ee?i?/iee ia?aa?a iinoeano?aoe?eiiai neiae?iio o ae?iie c /anii i?ney
iia?aoe?? aoa iaiaeiaeiaee. A?i caeaaeaa a?ae /ano iia?aoe?? a?aeiinii
iaiiiaoce (i?a- /e iinoia-iiiaoca), a?ae oa?aeoa?o aeno?aaai?oaeueii?
iaoieia?? (iayai?noue caoai?thaaiue, ye? ni?eythoue ii?ooaiith
eaeueoe??aiai iai?io, iaaei??ii? aaae o?ea). Anoaiiaeaii, ui
aeainoi?iiiy iaa??aeoii?y aaea /a?ac 3-4 i?n. aeeeeea? ?yae
aaaaoiiaa?ioe/ieo i?iy-a?a o aaaaoueio ae?iie, yeei aiie ia aoee
i?eoaiaii? aei iia?aoe??, oa iineeaiiy ?o ?i-oaineaiino?, yeui aiie aaea
aoee ?ai?oa. Ii?yae c eaaeei nooiaiai (33,33% ae?iie) o 20% iaoe??ioie
aeyaeyany oaeiae ? na?aaei?e nooi?iue iinoeano?aoe?eiiai neiae?iio. E??i
oiai, eiinoaoiaaii aeinoia??ia i?aeaeuaiiy ?iaeaeno Eoia?iaia o ae?iie,
i?iiia?iaaieo a i?aiaiiiaoc? (? oa ?? i?aea?oie) ii??aiyii c eiio?ieai,
oiae? ye o ae?iie, i?iiia?iaaieo a iinoiaiiiaoc? (???, ?V i?aea?oie),
oaeeo ci?i ia aeyaeaii. Iineeaiiy aaaaoiiaa?ioe/ieo i?iya?a o ae?iie,
i?iiia?iaaieo a i?aiaiiiaoc?, iiynith?oueny i?aeaeuaiiyi aeoeaiino?
a?iioaeaii-a?iio?ca?ii? nenoaie aiane?aeie aino?iai ano?iaaiiiai
aeao?oeeoo ? oi?ioaaiiyi a?iioaeai?/ii? aeenooieoe?? c iaaieie
ee?i?/ieie neiioiiaie. E??i oiai, i?e ?iaeea?aeoaeueiiio aiae?c?
anoaiiaeaii, ui o 58,33% ae?iie c a?oie ii??aiyiiy, ye? ia?aae
iia?aoe??th ia?aaoaaee a noai? iinoiaiiiaoce, aaaaoiiaa?ioe/i? i?iyae
oaeiae iineeeeenue i?ney ia?, ui na?ae/eoue i?i iaaio ?ieue aiaeiaaiieo
ano?iaai?a i?e caa?aaeaieo y?/ieeao a ciaioaii? ?ioaineaiino? ci?i a
nenoai? a?iioaeaion-a?iio?c.

*a?ac 3-4 i?n. i?ney iia?aoe?? nea?ae c aieo e?noeiai? nenoaie
aeyaeyeenue o 66,67% iaoe??ioie ae?iie c noiooiueith aeno?aaai?oaeueiith
iaoieia??th, yea ni?ey? ii-?ooaiith eaeueoe??aiai iai?io (V i?aea?oia),
oa o 40% ae?iie, i?iiia?iaaieo a iinoia-iiiaoc? c ii?iaeueiith aaaith
o?ea (?V i?aea?oia). A ?ioeo i?aea?oiao aiie aoee a?aenooi?.

I?e aiae?c? i?iya?a iinoeano?aoe?eiiai neiae?iio /a?ac 9-11 i?n. i?ney
iia?aoe?? aeyaeaii, ui iaiiiaocaeueiee ?iaeaen o ae?iie, i?iiia?iaaieo a
i?aiaiiiaoc? (?, ?? i?aea?oie), aoa aeinoia??ii aeuei ca ??aaiue
eiio?ieth, a, o i?iiia?iaaieo a iinoia-iiiaoc? (???, ?V i?aea?oie), – ia
a?ae??ciyany a?ae iueiai. Eaaeee nooi?iue aaaaoiiaa?ioe/-ieo i?iya?a
aeyaeyany o 30% ae?iie, na?aaei?e nooi?iue aaaeeino? – o 13,33%
iaoe??ioie. Nea?ae c aieo e?noeiai? nenoaie aeyaeyeenue o 28,6%
iaoe??ioie ? i?aea?oie, 28,57%-??, 80% — ???, 80%-?V oa 83,33%- V
i?aea?oie. ?o aeieeiaiiy o ae?iie inoaiiuei? i?aea?oie, i/aaeaeii,
iiaeia iiynieoe ii?ooaiiyie iaoaaie?cio e?noeiai? oeaieie, ye? ? no-iith
iane?aee?a ye o??o?a?/ii? eano?aoe??, oae ? iniiaiiai caoai?thaaiiy
e?noie.

Io?eiai? ?acoeueoaoe na?ae/aoue i?i oa, ui ?ioaineai?noue
aaaaoinoaeeiieo oa ineoiiaa?ioe/ieo i?iya?a iinoeano?aoe?eiiai neiae?iio
c /anii i?ney iia?aoe?? aeaui ciaioo?oueny, iaeiae na?aaeiuei/ania? oa
i?ci? i?iyae i?ia?anothoue.

I?ney eiiieaenii? ei?aeoe?? a?aeaoaaeanue ?aa?an?y an?o i?iya?a
iinoeano?aoe?eii-ai neiae?iio. Aiie aeyaeyeenue, ye c iaioith /anoioith,
oae ? c iaioith ?ioaineai?n-oth. Iieaciee ?iaeaeno Eoia?iaia o ae?iie,
i?iiia?iaaieo a iinoiaiiiaoc? (??? oa ?V i?aea?oie), aeinyaaa ??aiy
eiio?ieth, a a ae?iie, i?iiia?iaaieo a i?aiaiiiaoc? (? oa ?? i?aea?oie),
aoa iaa?oue aeinoia??ii ieae/ei.

Nea?ae c aieo e?noeiai? nenoaie i?ney e?eoaaiiy aeyaeyeeny o?eueee o 1,2
% ae?iie, i?iiia?iaaieo a iinoiaiiiaoc? aac iaaei??ii? aaae o?ea
(?Vi?aea?oia), oa o 1,2% iaoe??ioie c aeno?aaai?oaeueiith iaoieia??th,
ui ni?ey? ii?ooaiith iai?io eaeueoe?th a i?aai?ci? (V i?aea?oia).

Anoaiiaeaii, ui naia o??o?a?/ia ao?o/aiiy aieeaa?, iaaiith i??ith, ia
ia?aa?a iinoeano?aoe?eiiai neiae?iio, iieacieee ai?iiiaeueii? nenoaie oa
e?noeiaiai iaoaaie?cio. Aiii ia ci?ith? ??aaiue eaeueoe?th a e?ia?,
cieaeo? ??aaiue oinoi?o ? ca oeae ?aooiie ci?ith? iieaciee e?euee?niiai
ni?aa?aeiioaiiy eaeueoe?e/oinoi?. ??aaiue eoaeii? oinoaoace oa
eieaaaiace a ne?iaaooe? e?ia? /a?ac 48 aiaeei i?ney iia?aoe?? o an?o
ae?iie i?aeaeuo?oueny.

??aaiue oie?eoeinoeioethth/iai ai?iiio o ae?iie, ye? aoee i?iiia?iaai? a
i?a-iaiiiaoc? (? oa ?? i?aea?oie), oa o ae?iie, ui i?iiia?iaai? a
iinoiaiiiaoc? (??? oa ?V i?aea?oie eiio?ieth), aeinoia??ii ia
a?ae??ciyeenue i?ae niaith. Iaeiae aiie aeinoia??ii ??cieeenue a ?, ???
oa ??, ?V i?aea?oiao eiio?ieth. Io?eiai? aeai? na?ae/aoue i?i cia/i?
a?aei?iiino? a ??aiyo ai?iiio a caeaaeiino? a?ae iayaiino? /e
a?aenooiino? iaino?oaoe?? o ae?iie ia?ao?aeiiai a?eo. Aeinoia??ii?
??cieoe? a ??aiyo ano?aae?ieo a eiio?ie? ia aeya-eaii (?>0,05). *a?ac
9-11 i?n. i?ney o??o?a?/ii? eano?aoe?? ??aaiue ONA aoa aeinoia??ii aeuei
ca eiio?ieueiee o ae?iie c a?oie ii??aiyiiy, i?iiia?iaaieo a
i?aiaiiiaoc? (? oa ?? i?aea?oie), ? ia a?ae??ciyany a?ae oaeiai ae o
ae?iie, i?iiia?iaaieo a iinoiaii-iaoc? (??? oa ?V i?aea?oie). E??i oiai,
aeyaeaii aeinoia??ia cieaeaiiy ??aiy ano?aae?ieo a ne?iaaooe? e?ia? a ?
oa ?V i?aea?oiao. sse ? a aenia?eiaio?, a ?? oa ??? i?aea?oi? a?oie
ii??aiyiiy aeyaeaii o?eueee oaiaeaioe?th aei cieaeaiiy ??aiy
ano?aae?ieo. Oeae oaeo ua ?ac i?aeoaa?aeaeo? aeoieo i?i oa, ui ia oii?
a?eiaiai cieaeaiiy ??aiy ai?iiio iaae?iiy eiai i?e eano?aoe?? iaio
ae?aaeaia. Iaiaeiicia/i? ?acoeueoaoe i?e aiae?c? aeaieo ca iaoiaeii
ai?iiiaeueii? eieueiioeeoieia?? i?aeoaa?aeaeothoue aeoieo i?i oa, ui
ee?oeie i?oae o oeueiio ia??iae? aeeooy ae?iee ao?a/athoue /ooeea?noue
aei noaoaaeo ai?iii?a ? oiio ?acoeueoaoe iace?a iiaeooue
aeei?enoiaoaaoenue o?eueee a eiiieaeni?e ae?aaiinoeoe? noaio iaoe??ioie.

??aaiue ONA i?ney e?eoaaiiy ia a?ae??ciyany a i?aea?oiao iniiaii? a?oie
? aoa aeinoia??ii ieae/ei a ?, ?? oa ??? i?aea?oiao ? iaa oaiaeaioe?th
aei cieaeaiiy a ?V i?aea?oi? ii??aiyii c iieacieeaie o iae?eiaaieo
ae?iie. ??aaiue ano?aae?ieo o ae?iie i?ney e?eo-aaiiy aeinoia??ii aoa
aeuei ca iieacieee o iae?eiaaieo ae?iie ? aeinyaaa eiio?ieth a ?, ?? oa
?V i?aea?oiao iniiaii? a?oie ? a?ae??ciyany o?eueee a ??? i?aea?oi?.
Oeae iieaciee o ae?iie c iaee??iiyi (? oa ??? i?aea?oie) aoa cia/ii
aeuei ca a?aeiia?aeiee a ?? oa ?V i?aea?oiao. I/aaeaeii, aee?iaa oeaieia
? cia/iei aeaea?aeii ooai?aiiy aiaeiaaiieo ano?iaai?a. Ca aeaieie
eieueiioeeoieia?/iiai aeine?aeaeaiiy ia io?eiaii /?oei? ei?aeyoe?? i?ae
ai?noii iiaa?oiaaeo ee?oei oa EI? a i?aea?oiao iniiaii? a?oie. E??i
oiai, i?ney e?eoaaiiy a ??cieo i?aea?oiao ae?aaeai?noue ci?i aoea
??ciith.

Anoaiiaeaii caaaeuei? oaiaeaioe?? ci?i iieaciee?a e?noeiaiai iaoaaie?cio
a ae?-iie on?o i?aea?oi — cieaeaiiy ??aiy eaeueoe?th a ne?iaaooe? e?ia?
aaea /a?ac 3-4 i?n. i?ney iia?aoe??, yeee iaaeae? i?aeo?eio?oueny ia
i?i?iaeueiiio ??ai?. Aeyaeaii i?aeaeuaiiy aeoeaiino? oa?iaio?a (eoaeii?
oinoaoace oa eieaaaiace), yea iiaea aooe iaoiiaeaii caeeoeiaeie
caiaeueieie i?ioeanaie, ine?eueee /a?ac 9-11 i?n. i?ney aeaeaeaiiy
y?/iee?a a?aeaoaa?oueny cieaeaiiy aeoeaiino? eieaaaiace. Aeoeai?noue
eoaeii? oinoaoa-ce iaaeae? c?inoa? ?, iaiaaia, a?aeia?aaea?
?ioaineai?noue e?noeiaiai ?aiiaeoethaaiiy. I?ney eiiieaenii? ei?aeoe?? o
an?o i?aea?oiao eiinoaoiaaii i?aeaeuaiiy ??aiy eaeueoe?th oa cieaeaiiy
aeoeaiino? eoaeii? oinoaoace oa eieaaaiace. ??ai? oinoi?o a ne?iaaooe?
e?ia?, iieacieee e?euee?niiai ni?aa?aeiioaiiy eaeueoe?e/oinoi? oa
aeiaiai? aene?aoe?? eaeueoe?th c na/ath a ae?iie on?o i?aea?oi
aeinoia??ii ia ci?iththoueny i? i?ney o??o?a?/ii? eano?aoe??, i? i?ney
cai?nii? ai?iiiaeueii? oa?ai?? (?en.1, ?en.2, ?en.3).

O ae?iie, ye? aoee i?iiia?iaai? a i?aiaiiiaoc? c iaee??iiyi 2-3 nooiaiy
(? i?aea?oia), ??aaiue eaeueoe?th a e?ia? ia 3-4 i?n. i?ney eano?aoe??
aoa aeinoia??ii ieae/ei ca oie, yeee ?a?no?oaaany aei iia?aoe??
(a?aeiia?aeii 2,2450,04iiieue/e ii??aiyii c 2,3970,08iiieue/e, ?<0,05), oa ca eiio?ieueiee, a aeoeai?noue eoaeii? oinoaoace aeinoia??ii aeuith ca iieaciee, ca?a?no?iaaiee aei iia?aoe?? (73,25,35U/l ii??aiyii c 61,175,1U/l, ?<0,01), oi/ ? ia a?ae??ciyeanue a?ae ??aiy eiio?ieth (?>0,05).

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?en.1. ??aaiue eaeueoe?th o ae?iie ia?eiaiiiaocaeueiiai a?eo
/a?ac 3-4 oa 9-11i?n i?ney iia?aoe??.

A?oie: -eiio?ieue, a?oia ii??aiyiiy: -/a?ac 3-4 i?n., —
/a?ac 9-11 i?n. i?ney eano?aoe??

Aeinoia??i?noue : * — c eiio?ieai, ^ -c a?oiith ii??aiyiiy aei
iia?aoe??.

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0902c0c0c000070000001604c0007c0200000000040000002d010100040000002d010000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?en.3.Aeoeai?noue eieaaaiace a ne?iaaooe? e?ia? ae?iie ee?iaeoa?e/iiai
a?eo /a?ac 3-4 oa 9-11i?n. i?ney iia?aoe??.

A?oie: -eiio?ieue, a?oia ii??aiyiiy: -/a?ac 3-4 i?n., — /a?ac 9-11 i?n.
i?ney eano?aoe??

Aeinoia??i?noue : * — c eiio?ieai, ^ -c a?oiith ii??aiyiiy aei
iia?aoe??.

Aaaeeeai cacia/eoe, ui o iaoe??ioie c aoi?eiiei caai?iiyi
i?neyiia?aoe?eieo ?oaoe?a aeoeai?noue oa?iaioo aoea cia/ii aeuith, i?ae
a na?aaeiueiio a i?aea?oi?, ui iiaea aooe ni?e/eiaii caeeoeiaeie
caiaeueieie i?ioeanaie, ye? ua o?eaathoue i?ney iia?aoe??. *a?ac 3-4
i?n. i?ney o??o?a?/ii? eano?aoe?? o iaoe??ioie oe??? i?aea?oie aeyaeaii
aeinoia??ia i?aeaeuaiiy aeoeaiino? eieaaaiace ii a?aeiioaiith aei
iieacieea, yeee ?a?no?oaaany aei iia?aoe?? (2,670,19ieao ii??aiyii c
2,0130,26ieao, ?<0,01), oi/ ?? ai?no ia a?ae??ciyany a?ae eiio?ieth (?>0,05). Io?eiai? ?acoeueoaoe, i/aaeaeii, oaeiae iiaeia iiynieoe
caeeoeiaeie caiaeueieie ci?iaie, ine?eueee aeinoia??ii? ??cieoe?
ii??aiyii c eiio?ieai aeyaeoe ana ae oaee ia aaeaeinue.

*a?ac 9-11 i?n i?ney iia?aoe?? ??aaiue eaeueoe?th caeeoaany iecueeei
(2,1490,03iiieue/e) ? ia a?ae??ciyany a?ae iieacieea, yeee ?a?no?oaaany
ia 3-4 i?n. (?>0,05), oi/ ? a?ae??ciyany a?ae ??aiy eiio?ieth oa
iieacieea, yeee ?a?no?oaaany aei iia?aoe?? (?<0,05). Aeoeai?noue eoaeii? oinoaoace aoea aeinoia??ii aeuith ca iieaciee, yeee ?a?no?oaaany aei iia?aoe?? (89,865,2U/l, ?<0,001), oa ca ??aaiue eiio?ieth (?<0,01). *a?ac 9-11 i?n. ii a?aeiioaiith aei a?aeiia?aeieo iieaciee?a /a?ac 3-4 i?n. i?ney eano?aoe?? aeyaeaii aeinoia??ia cieaeaiiy aeoeaiino? eieaaaiace (2,230,17ieao, ?<0,02), yea aeinyaaea ??aiy eiio?ieth (?>0,05). Aeyaeaii i?aeaeuaiiy ??aiy ai?ii-acioo, yeee aeinoia??ii
a?ae??ciyany, ye a?ae ??aiy eiio?ieth, oae ? a?ae iieaciee?a a a?o-i?
ii??aiyiiy aei iia?aoe?? oa /a?ac 3-4 i?n. i?ney ia?. ??aaiue oinoi?o a
ne?iaaooe? e?i-a?, iieacieee e?euee?niiai ni?aa?aeiioaiiy
eaeueoe?e/oinoi? oa aeiaiai? aene?aoe?? eaeue-oe?th c na/ath ia
a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??aiyiiy aei iia?aoe??
(?>0,05).

I?ney e?eoaaiiy o ae?iie, ye? aoee i?iiia?iaai? a i?aiaiiiaoc? c
iaee??iiyi 2-3 nooiaiy (? i?aea?oia), ai?no eaeueoe?th a ne?iaaooe?
e?ia? aeinyaaa ??aiy eiio?ieth (?>0,05), aoa aeinoia??ii aeuei ca
a?aeiia?aeiee o iae?eiaaieo ae?iie (?<0,01) ? noa-iiaea 2,5020,03iiieue/e. Aeoeai?noue eoaeii? oinoaoace i?ney eiiieaenii? ei?aeoe?? cieaeoaaeany (63,85,9U/l) ? aeinoia??ii ia a?ae??ciyeany a?ae eiio?ieth (?>0,05). Aeoeai?noue eieaaaiace oa ??aaiue ai?iacioo
aeinyaaee eiio?ieth (?>0,05).

O ae?iie, i?iiia?iaaieo a i?aiaiiiaoc? aac iaaei??ii? aaae o?ea /e c
iaee??i-iyi ? nooiaiy (?? i?aea?oia), ia 3-4 i?n. i?ney eano?aoe??
eiinoaoiaaii aeinoia??ia cie-aeaiiy ??aiy eaeueoe?th ii??aiyii c
iieacieeii, yeee ?a?no?oaaany aei iia?aoe?? (2,0370,05iiieue/e ii??aiyii
c 2,2170,04iiieue/e, ?<0,05), oa aeinoia??ia i?aeaeuaiiy aeoeaiino? eoaeii? oinoaoace oa eieaaaiace ii??aiyii c iieacieeaie o oe?e i?aea?oi? aei iia?aoe?? (a?aeiia?aeii 75,35,3U/l ii??aiyii c 69,154,9U/l) oa (2,680,28ieao ii??aiyii c 1,9650,25ieao, ?<0,01). Anoaiiaeaii aeinoia??ia i?aeaeuaiiy ??aiy ai?iiiai acioo ii??aiyii c aeaieie aei iia?aoe?? oa a?aenooi?noue aoaeue-yeeo ci?i a ??ai? oinoi?o, iieacieeo eaeueoe?e/oinoi? oa aeiaia?e aene?aoe?? eaeueoe?th c na/ath ii??aiyii c eiio?ieai oa a?oiith ii??aiyiiy aei iia?aoe??. sse ? a iiia?aaei?e i?aea?oi? /a?ac 9-11 i?n. i?ney eano?aoe?? ??aaiue eaeueoe?th a e?i-a? caeeoaany iecueeei (2,0250,04iiieue/e) ? ia a?ae??ciyany a?ae iieacieea, yeee ?a-?no?oaaany ia 3-4 i?n (?>0,05), oi/
? a?ae??ciyany a?ae ??aiy eiio?ieth oa iieacieea a oe?e i?aea?oi? aei
iia?aoe?? (?<0,05). Anoaiiaeaii aeinoia??ia i?aeaeuaiiy aeoeaiino? eoaeii? oinoaoace ii a?aeiioaiith aei iieaciee?a, ye? ?a?no?oaaeenue aei iia?aoe?? (88,783,0U/l, ?<0,01), oa ii a?aeiioaiith aei eiio?ieth (?<0,02). *a?ac 9-11 i?n. i?ney eano?aoe?? aeyaeaii aeinoia??ia cieaeaiiy aeoeaiino? eieaaaiace (2,260,19ieao) ii a?aeiioaiith aei a?aeiia?aeiiai iieacieea /a?ac 3-4 i?n. (?<0,01). Anoaiiaeaii i?ae-aeuaiiy ??aiy ai?iiacioo, yeee aeinoia??ii a?ae??ciyany a?ae ??aiy eiio?ieth, a?ae ii-eaciee?a a a?oi? ii??aiyiiy aei iia?aoe?? oa /a?ac 3-4 i?n. i?ney ia? (?>0,05). ??aaiue oinoi?o a e?ia?, iieacieee
ni?aa?aeiioaiiy eaeueoe?e/oinoi? oa aeiaiai? aene?aoe?? eaeueoe?th c
na/ath ia a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??aiyiiy aei
iia?aoe??.

I?ney i?iaaaeaiiai e?eoaaiiy ae?iie, ye? aoee i?iiia?iaai? a
i?aiaiiiaoc? aac iaee??iiy, ??aaiue eaeueoe?th aoa aeinoia??ii aeuei ca
eiio?ieueiee (?<0,001) oa a?aeii-a?aeiee o iae?eiaaieo ae?iie (2,4090,03iiieue/e, ?<0,01). Aeoeai?noue eoaeii? oinoa-oace i?ney e?eoaaiiy cieaeoaaeanue (67,445,9U/l) ? aeinoia??ii ia a?ae??ciyeanue a?ae eiio?ieth (?>0,05). Aeoeai?noue eieaaaiace ? ??aaiue ai?iiacioo
aeinyaaee eiio?ieth (?>0,05)

O iaoe??ioie, ye? aoee i?iiia?iaai? a iinoiaiiiaoc? c iaee??iiy 2-3 no
(??? i?ae-a?oia), ia 3-4 i?n. i?ney eano?aoe?? eiinoaoiaaii aeinoia??ia
cieaeaiiy ??aiy eaeueoe?th ii??aiyii c iieacieeii, aei iia?aoe??
(2,1230,03iiieue/e ii??aiyii c 2,279 0,05iiieue/e, ?<0,05), oa c eiio?ieai (?<0,05). Aeyaeaii a?aenooi?noue ci?i a aeoea-iino? eoaeii? oinoaoace ii??aiyii c aeaieie aei iia?aoe?? (77,84,5U/l ii??aiyii c 65,877,5U/l, ?>0,05) oa c eiio?ieai (?>0,05). *a?ac 3-4 i?n. i?ney
o??o?a?/ii? eano-?aoe?? o ae?iie oe??? i?aea?oie aeyaeaii aeinoia??ia
i?aeaeuaiiy aeoeaiino? eieaaaiace ii a?aeiioaiith aei iieacieea, yeee
?a?no?oaaany aei iia?aoe?? (2,70,22ieao ii??aiyii c 1,9160,2ieao,
?<0,001), oi/a a?i ? ia a?ae??ciyany a?ae eiio?ieth (?>0,05).
Anoaiia-eaii aeinoia??ia i?aeaeuaiiy ??aiy ai?iiiai acioo ii??aiyii c
iieacieeaie aei iia-?aoe??, a ??aaiue oinoi?o a ne?iaaooe? e?ia?,
iieaciee eaeueoe?e/oinoi? oa aeiaiaa aene-?aoe?y eaeueoe?th c na/ath ia
a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??aiyiiy aei iia?aoe??.

Ia 9-11 i?n i?ney iia?aoe?? ai?no eaeueoe?th a e?ia? ae?iie, ye?
i?iiia?iaai? a iinoiaiiiaoc? c iaee??iiy 2-3 no, caeeoaany iecueeei ? ia
a?ae??ciyany a?ae ??aiy, yeee ?a?no?oaaany ia 3-4 i?n. (2,143
0,02iiieue/e). Anoaiiaeaii aeinoia??ia i?aeaeuaiiy aeoeaiino? eoaeii?
oinoaoace ii a?aeiioaiith aei iieacieea o o?e nai?e a?oi?, yeee
?a?no?oaaany aei iia?aoe?? (90,94,7U/l, ?<0,01), oa aei eiio?ieth (?<0,05). *a?ac 9-11 i?n. aeyaeaii aeinoia??ia cieaeaiiy aeoeaiino? eieaaaiace (2,310,26ieao ?<0,01) ii??aiyii c iieacieeaie ia 3-4 i?n. i?ney eano?aoe??. Anoaiiaeaii ua a?eueo cia/ia i?aeaeuaiiy ??aiy ai?iiacioo. A?i aeinoia??ii a?ae??ciyany, ye a?ae ??aiy eiio?ieth, oae ? a?ae iieaciee?a a a?oi? ii??aiyiiy aei iia?aoe?? oa /a?ac 3-4 i?n. i?ney ia?. ??aaiue oinoi?o a ne?iaaooe? e?ia?, iieaciee eaeueoe?e/oinoi? oa aeiaiai? aene?aoe?? eaeueoe?th c na/ath ia a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??aiyiiy aei iia?aoe??. I?ney e?eoaaiiy ae?iie, ye? aoee i?iiia?iaai? a iinoiaiiiaoc? c iaee??iiy 2-3 no, ??aaiue eaeueoe?th aeinyaaa eiio?ieth (?>0,05) ? aoa
aeinoia??ii aeuei ca a?aeiia?aeiee o iae?eiaaieo ae?iie
(2,5070,04iiieue/e, ?<0,01).Aeoeai?noue eoaeii? oinoaoace cie-aeoaaeanue (70,78,05U/l) ? aeinoia??ii ia a?ae??ciyeanue a?ae eiio?ieth (?>0,05).
I?ney ei?aeoe?? aeoeai?noue eieaaaiace oa ??aaiue ai?iiacioo oaeiae
aeinyaaee eiio?ieth.

O ae?iie, i?iiia?iaaieo a iinoiaiiiaoc? c ii?iaeueiith aaaith o?ea /e
iaee??i-iyi ? no (?V i?aea?oia), ia 3-4 i?n. i?ney eano?aoe??
eiinoaoiaaii cieaeaiiy ??aiy eaeue-oe?th ii??aiyii c iieacieeii, yeee
?a?no?oaaany aei iia?aoe?? (a?aeiia?aeii 2,028 0,05iiieue/e ii??aiyii c
2,2350,07iiieue/e, ?>0,05). Aeyaeaii a?aenooi?noue ci?i o aeoeaiino?
eoaeii? oinoaoace ii??aiyii c aeaieie aei iia?aoe?? (a?aeiia?aeii 75,2
8,2U/l ii??aiyii c 65,885,7U/l, ?>0,05), oa c eiio?ieai (?>0,05) ?
aeinoia??ia i?aeae-uaiiy aeoeaiino? eieaaaiace ii a?aeiioaiith aei
iieacieea, ca?a?no?iaaiiai aei iia-?aoe?? (2,66 0,27ieao ii??aiyii c
1,930,22ieao, ?<0,01), oi/a ?? ??aaiue ia a?ae??ciya-ny a?ae eiio?ieth (?>0,05). *a?ac 3-4 i?n. i?ney o??o?a?/ii? eano?aoe?? ii???yaiyii c
aea-ieie aei iia?aoe?? ?a?no?oaaeinue aeinoia??ia i?aeaeuaiiy ??aiy
ai?iiiai acioo oa a?ae-nooi?noue aoaeue-yeeo ci?i a ??ai? oinoi?o,
iieacieeo ni?aa?aeiioaiiy eaeueoe?e/oinoi?.

O ae?iie ?V i?aea?oie /lang1033 a?ac 9-11 i?n i?ney o??o?a?/ii?
eano?aoe?? ??aaiue eaeueoe?th a e?ia? caeeoaany iecueeei
(1,9630,04iiieue/e) ? ia a?ae??ciyany a?ae iieacieea, ca?a-?no?iaaiiai
ia 3-4 i?n. (?>0,05), oi/a ? a?ae??ciyany a?ae iieacieea, yeee
?a?no?oaaany aei iia?aoe?? o oe?e i?aea?oi? (?<0,05). Anoaiiaeaii aeinoia??ia i?aeaeuaiiy aeoeaiino? eoaeii? oinoaoace ii??aiyii c iieacieeii o o?e nai?e a?oi? aei iia?aoe?? (92,8 6,15U/l, ?<0,02). *a?ac 9-11 i?n. aeyaeaii aeinoia??ia cieaeaiiy aeoeaiino? eieaaa-iace ii??aiyii c iieacieeii /a?ac 3-4 i?n. i?ney eano?aoe?? (2,280,29ieao, ?<0,01) oa ua a?eueo cia/ia i?aeaeuaiiy ??aiy ai?iiiacioo. Inoaii?e aeinoia??ii a?ae??ciyany, ye a?ae ??aiy eiio?ieth, oae ? a?ae iieaciee?a a a?oi? ii??aiyiiy aei iia?aoe?? oa /a?ac 3-4 i?n. i?ney ia?. ??aaiue oinoi?o a e?ia?, iieaciee eaeueoe?e/oinoi? oa aee'eeaiai? aene?aoe?? eaeueoe?th c na/ath ia a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??aiyiiy aei iia?aoe??. I?ney i?iaaaeaiiai e?eoaaiiy ??aaiue eaeueoe?th aoa aeinoia??ii aeuei ca ??aaiue eiio?ieth (2,3120,04iiieue/e, ?<0,05) oa ca a?aeiia?aeiee o iae?eiaaieo ae?iie (?<0,01). Iieaciee aeoeaiino? eoaeii? oinoaoace a aeeiai?oe? eiiieaen?i? ei?aeoe?? cieaeoaaany (72,43,8U/l) ? aeinoia??ii ia a?ae??ciyany a?ae eiio?ieth (?>0,05). Iieacieee aeoeaiino? eieaaaiace
oa ??aiy ai?iiacioo aeinyaaee eiio?ieth (?>0,05).

O ae?iie c aeno?aaai?oaeueiith iaoieia??th, ui ni?ey? ii?ooaiith iai?io
eaeue-oe?th (oeoe?iaee ae?aaao, caoai?thaaiiy e?noeiai-i’ycaai? nenoaie
(?aaiaoeci, inoai-oiiae?ic, caoai?thaaiiy oeoieiai-eeoeiaiai o?aeoo)
(Vi?aea?oia), aeoeai?noue eoae-ii? oinoaoace aei iia?aoe?? aoea
aeinoia??ii aeuith a?ae ?aooe i?aea?oi (88,577,8U/l, ?<0,05). I/aaeaeii, a?eueo aenieee iieaciee o oe?e i?aea?oi? iiaycaiee c? ci?iith ia-oaaie?cio e?noeiai? oeaieie i?e noiooi?o aeno?aaai?oaeueieo caoai?thaaiiyo. Ia 3-4 i?n. i?ney eano?aoe?? aeoeai?noue eoaeii? oinoaoace ia a?ae??ciyeanue a?ae eiio?ieth (86,14,65U/l ii??aiyii c 88,577,8U/l, ?>0,05). Eiinoaoiaaii cieaeaiiy ??aiy eaeue-oe?th ii??aiyii
c iieacieeaie, ye? ?a?no?oaaeenue o oe?e i?aea?oi? aei iia?aoe?? (1,972
0,03iiieue/e ii??aiyii c 2,1240,03iiieue/e). Io?eiaii aeinoia??ia
i?aeaeuaiiy aeoeaiino? eieaaaiace ii??aiyii c iieacieeii aei iia?aoe??
(2,690,22ieao.ii??aiyii c 1,940,21ieao, ?<0,05), oi/a aiia ia a?ae??ciyeanue a?ae eiio?ieth (?>0,05). Aeyaeaii aeinoia??ia i?aeaeuaiiy
??aiy ai?iiiai acioo, a ai?no oinoi?o a ne?iaaooe? e?ia?, iieaciee
eaeueoe?e/oinoi? oa aeiaiaa aene?aoe?y eaeueoe?th c na/ath ia
a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??aiyiiy aei iia?aoe??.

*a?ac 9-11 i?n. i?ney o??o?a?/ii? eano?aoe?? ??aaiue eaeueoe?th a e?ia?
ae?iie c aeno?aaai?oaeueiith iaoieia??th, ui ni?ey? ii?ooaiith
eaeueoe??aiai iai?io a i?aai?ci?, ia a?ae??ciyany a?ae iieacieea, yeee
?a?no?oaaany ia 3-4 i?n. (1,9740,05iiieue/e, ?>0,05). Aeoeai?noue
eoaeii? oinoaoace aeinoia??ii ia a?ae??ciyeanue a?ae iieacieea aei
iia?aoe?? (94,54,13U/l, ?>0,05). *a?ac 9-11 i?n ii a?aeiioaiith aei
a?aeiia?aeieo iieaciee?a /a?ac 3-4 i?n. i?ney eano?aoe?? aeyaeaii
aeinoia??ia cieaeaiiy aeoeaiino? eieaaaiace (2,290,25ieao, ?<0,02). Anoaiiaeaii ua a?eueo cia/ia i?aeaeuaiiy ??aiy ai?iiacioo, yeee aeinoia??ii a?ae??ciyany a?ae ??aiy eiio?ieth ? a?ae iieaciee?a a a?oi? ii??aiyiiy aei iia?aoe?? oa /a?ac 3-4 i?n. i?ney ia?. ??aaiue oinoi?o a ne?iaaooe? e?ia?, iieacieee ni?aa?aeiioaiiy eaeueoe?e/oinoi? a e?i-a? oa aeiaiai? aene?aoe?? eaeueoe?th c na/ath ia a?ae??ciyeenue a?ae eiio?ieth oa a?oie ii??a-iyiiy aei iia?aoe??. I?ney e?eoaaiiy ??aaiue eaeueoe?th aoa aeinoia??ii aeuei ca a?aeii-a?aeiee o iae?eiaaieo ae?iie (2,2450,04iiieue/e, ?<0,01) ? aeinyaaa ??aiy eiio?ieth (?>0,05). Iaeiae,
ai?no eaeueoe?th a oe?e i?aea?oi? caeeoaany aeinoia??ii ieae/ei a?ae
??a-iy ?, ?? oa ??? i?aea?oi. Aeoeai?noue eoaeii? oinoaoace i?ney
eiiieaenii? ei?aeoe?? cie-aeoaaeanue (81,35 6,0U/l) ? aeinoia??ii ia
a?ae??ciyeanue a?ae eiio?ieth (?>0,05). Aeoea-i?noue eieaaaiace oa
??aaiue ai?iiacioo aeinyaaee eiio?ieth (?>0,05). Caeiiii??iinoae,
iiaycaieo c aeaeaeaiiyi y?/iee?a, a oaeiae i?ney e?eoaaiiy a ??ai?
oinoi?o oa iieac-ieeo eaeueoe?e/oinoi?, a aeiaia?e aene?aoe?? eaeueoe?th
a ianoaaeaieo ae?iie ia aeyaeaii.

I?e aea/aii? ?aioaaiia?ai eenoae o ae?iie /a?ac 9-11 i?n. i?ney iia?aoe?
oa a eiio?ie?, ia io?eiaii aeinoia??ieo a?aei?iiinoae, ui aea? i?aenoaao
aeoiaoe i?i oa, ui ia aeaiiio aoai? oeae iaoiae ia ?ioi?iaoeaiee.

Io?eiai? ?acoeueoaoe na?ae/aoue i?i iayai?noue ci?i e?noeiaiai
iaoaaie?cio o ae?iie ia?eiaiiiaocaeueiiai a?eo. O??o?a?/ia eano?aoe?y c
i?eaiaeo aeia?iye?nieo iooeei iaoee /e y?/iee?a aeeeeea? o oeueiio a?oe?
iineeaiiy a?iiano?iaai?cio, yeee aaaea aei aeieeiaiiy ii?ooaiue a
a?iioaeaii-a?iio?ca?ii-y?/ieeia?e nenoai?, ? noi?iaiaeaeo?oueny ?aii?i
aeieeiaiiyi on?o neiioii?a iinoeano?aoe?eiiai neiae?iio aaea i?ioyaii
ia?oiai ?ieo i?ney iia?aoe??, iaa?oue oeo, ye? aac ia? i?iyaeythoueny
/a?ac 3-5-7 ?ie?a. ?aii? eiia?iiaaia i?ecia/aiiy i?aia?ao?a eaeueoe?th
oa cai?nii? ai?iiiioa?ai?? iaoo?aeueieie ano?iaai-aanoaaaiieie
i?aia?aoaie i?ney o??o?a?/ii? eano?aoe?? a ia?e- oa iinoiaiiiaoc? ni?ey?
ciaioaiith ?ioaineaiino? aeyaeaieo ci?i ? ? aaaeeeaei iiiaioii a
i?io?eaeoeoe? inoaiii?ico, yeee aeicaieeoue cia/ii cieceoe e?euee?noue
ia?aeii?a, ni?e/eiaieo ianoa/ath noaoaaeo ai?iii?a.

AENIIAEE

1.Aeaeaeaiiy y?/iee?a a ia?ao?aeiiio a?oe? i?ecaiaeeoue aei i?iyao
neiioii?a ano?iaaiiiai aeao?oeeoo cia/ii ?ai?oa, i?ae o ae?iie c
?ioaeoieie y?/ieeaie o oeueiio a?oe?. Oae, aaaaoiiaa?ioe/i? neiioiie
aeyaeythoueny aaea a ia?o? 3i?n. i?ney iia?aoe??, o?iaai?oaeuei? oa
e?noeia? — i?ioyaii ia?oiai ?ieo i?ney ia?. Nooi?iue ?o oyaeeino? oa /an
ii/aoeo caeaaeeoue a?ae oiai, i?iiia?iaai? aoee ae?iee a i?a- /e
iinoiaiiiaoc?, a?ae iayaiino? aeno?aaai?oaeueii? iaoieia??.

2.O??o?a?/ia eano?aoe?y o uo??a c??eiai a?eo aaaea aei ?aii?o ci?i
e?noeiaiai iaoaaie?cio, a naia, aei cieaeaiiy ??aiy eaeueoe?th oa
aeoeaiino? eoaeii? oinoaoace, ? aei i?iyao iciae inoaiaeeno?io?? aaea
/a?ac 6 oeaei?a i?ney iia?aoe??. Iioeiaeueii aoaeoeaiith aeicith
ao?i?eano?aae?ieo aeey ei?aeoe?? eaeueoe??aiai iai?io i?ney
aeainoi?iiiuei? iaa??aeoii?? ? 0,06-0,09 iea/ae aeey uo??a aaaith
300±20a., ui a 1,5-2 ?. ieae/a, i?ae caaaeueiii?eeiyoa aeica, yea
aeei?enoiao?oueny aeey e?eoaaiiy inoaiii?ico.

3.”A?oio ?eceeo” ii ?aiiueiio aeieeiaiith ci?i o iaoaaie?ci? e?noeiai?
oeaieie neeaaeathoue ae?iee c aeno?aaai?oaeueiith iaoieia??th, yea
ni?ey? ii?ooaiith iai?io eaeueoe?th a i?aai?ci? (?aaiaoeci,
inoaioiiae?ic, oeoe?iaee ae?aaao, caoai?thaai-iy oeoieiai-eeoeiaiai
o?aeoo). Oaeoi?ii caoenoo a?ae aeuacaaaeaieo ii?ooaiue ? aee?iaa
oeaieia, aea a?aeaoaa?oueny aeno?aaiiaaeaeueia ooai?aiiy ano?iaai?a.

4.O ae?iie, ye? ia?aianee iia?aoe?? c i?eaiaeo aeia?iye?nieo iooeei
aioo??oi?o noaoaaeo i?aai?a c aeaeaeaiiyi y?/iee?a o
ia?eiaiiiaocaeueiiio a?oe?, a?aei?/aii iineeaiiy ano?iaaiiiai aeao?oeeoo
ia oii? a?ia?i?iaeoeoe?? aiiaaeio?ii?i?a.

5.O??o?a?/ia eano?aoe?y o ae?iie ee?iaeoa?e/iiai a?eo /a?ac 9-11 i?n.
aaaea aei ci?i iieaciee?a e?noeiaiai ?aiiaeoethaaiiy, a naia, aei
cieaeaiiy ??aiy eaeueoe?th (2,1490,03iiieue/e – 1,9630,04iiieue/e
ii??aiyii c 2,4590,07iiieue/e – 2,10,06iiieue/e a eiio?ie?),
i?aeaeuaiiy aeoeaiino? caaaeueii? eoaeii? oinoaoace a ne?iaaooe? e?ia?
(89,865,2U/l–94,54,13U/l ii??aiyii c 61,175,1U/l – 88,577,8U/l a
eiio?ie?). A?aei?iiino? a i?aea?oiao iia’ycai? c? noaiii iaino?oaeueii?
ooieoe?? (i?a- /e iinoiaiiiaoca), c iayai?noth aeno?aaai?oaeueii?
iaoieia??.

6.Aoaeoeaiei iaoiaeii i?io?eaeoeee ii?ooaiue e?noeiaiai iaoaaie?cio o
ae?iie ia?ao?aeiiai a?eo, ye? ia?aianee iia?aoe?? c aeaeaeaiiyi y?/iee?a
c i?eaiaeo aeia?iye?nieo iooeei aioo??oi?o aai?oae?e, ? canoinoaaiiy
iaoo?aeueieo ano?iaai-aanoaaaiieo eiiieaen?a o ii?aeiaii? c i?aia?aoaie
eaeueoe?th. E?eoaaiiy iiaeiii i?ecia/aoenue /a?ac 3-4 i?n. i?ney
iia?aoe??. Canoinoaaiiy aeuacacia/aii? oa?ai?? i?ioyaii 5-6 i?n. aaaea
aei ciaioaiiy ?ioaineaiino? aai aei iiaiiai cieeiaiiy
aaaaoiiaa?ioe/ieo, o?iaai?oaeueieo oa e?noeiaeo i?iya?a, aei i?aeaeuaiiy
??aiy eaeueoe?th oa cieaeaiiy ??aiy eoaeii? oinoaoace ia oii?
ii?iae?caoe?? iieaciee?a ooieoe?? a?iio?ca?ii-y?/ieeiai? nenoaie.

7.Cai?nia ai?iiiaeueia oa?ai?y o ae?iie c iaee??iiyi iiaeiia
i?iaiaeeoenue i?ae ieeueiei eiio?ieai (a?iaioaeueia aeine?aeaeaiiy,
ianoaaeaiiy iiei/ieo caeic, oeeoieia?/ia aeine?aeaeaiiy iace?a c i?oae).
Aeica ai?iiiaeueieo i?aia?ao?a iiaeiia i?aeae?aoenue ?iaeea?aeoaeueii ?
iiaea aooe ciaioaia.

IA?AE?E ?IA?O, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe??

1. Inoaiii?ic a ia?e- oa iinoiaiiiaoc? : ee?i?ea, ae?aaiinoeea,
e?eoaaiiy // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.-1995.-?6.-N.57-62.
(ni?aaao. Iaai?ia A.O.).

2. Eaeueoe?e oa eaeueoe?e?aaoethth/a nenoaia a ii?i? oa i?e ii?ooaiiyo
ooieoe?? y?/iee?a // Iaae?ao??y, aeooa?noai oa a?iaeieia?y.-1996.-
?5-6.-N.90-93. (ni?aaao. Iaai?ia A.O.).

3. Ee?i?/iee ia?aa?a a?aeaeaeaiiai i?neyiia?aoe?eiiai ia??iaeo o ae?iie
ee?iaeoa?e/-iiai a?eo i?ney o??o?a?/ii? eano?aoe?? // Iaae?ao??y,
aeooa?noai oa a?iaeieia?y.-1998.-?1.-N.36-38. (ni?aaao. Iaai?ia A.O.,
Oth?aa I.A.).

4. ?aaaeeeoaoeey aeaiuei iinoiaiiiao-caeueiiai aic?anoa iinea
?aaeeeaeueiuo aeia-eieiae/aneeo iia?aoeee // I?iaeaiu noa?aiey e
aeieaieaoey.-1998.-?2.-N.161-166. (ni?aaao. Iaai?ia A.O., Oth?aa I.A.).

5.Aea/aiiy iieaciee?a e?noeiaiai iaoaaie?cio o ae?iie
ia?eiaiiiaocaeueiiai a?eo i?ney o??o?a?/ii? eano?aoe?? // Iaoa??aee ??
Oe?a?inueei? iaoeiai-i?aeoe/ii? eiioa?aioe?? Inoaiii?ic: ai?aeai?ieia?y,
ee?i?ea, ae?aaiinoeea, i?io?eaeoeea oa e?eoaaiiy.- Ee?a.-1997.-N.85-87.
(ni?aaao. Iaai?ia A.O., Aia?in?e/oe ss.ss.).

6.I?io?eaeoeea inoaiii?ico o ae?iie a ee?iaeoa?e/iiio ia??iae? i?ney
aeainoi?iiiuei? iaa??aeoii?? // Iaoa??aee O c?caeo aeooa??a-a?iaeieia?a
Oe?a?ie.-Iaeana.-1996.- N.53-54. (ni?aaao. Iaai?ia A.O.).

7.Aea/aiiy ii?ooaiue eaeueoe??aiai iai?io o uo??a i?ney aeainoi?iiiuei?
iaa??aeoii??// Iaoa??aee ? Oe?a?inueei? iaoeiai-i?aeoe/ii? eiioa?aioe??
“Inoaiii?ic ai?aeai?ieia?y, ee?i?ea, ae?aaiinoeea, e?eoaaiiy oa
i?io?eaeoeea”.–Ee?a.-1995.-N.50-51. (ni?aaao. Iaai?ia A.O.).

8.Aeaye? iieacieee e?noeiaiai iaoaaie?cio o ae?iie a ee?iaeoa???
aeainoinoi?iiiuei? iaa??aeoii?? // Iaoa??aee iaoeiai-i?aeoe/ii?
eiioa?aioe?? Aeooaeuei? i?iaeaie aa??ao?e/ii? i?oiiaae??.-
Ee?a.-1996.-N.69-70. (ni?aaao. Iaai?ia A.O.).

AIIOAOe??

A?eai?ueaaa I.A.Iniaaiiinoe iieacaoaeae einoiiai iaoaaieecia o e eo
ei??aeoeey o aeaiuei ia?eiaiiiaocaeueiiai aic?anoa iinea aeainoi?iiiae
iaa?eyeoiiee (yenia?eiaioaeueii-eeeie/aneia enneaaeiaaiea). — ?oeiienue.

Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo
iaoe ii niaoeeaeueiinoe 14.01.01- aeooa?noai e aeiaeieiaey. — Iaeanneee
ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao IC Oe?aeiu,Iaeanna, 1998
aiae.

A aeaiiii enneaaeiaaiee onoaiiaeaii, /oi oaeaeaiea ye/ieeia o naiie e?un
c?aeiai aic?anoa eeiee Aenoa? aaaeao e ?aiiei eciaiaieyi einoiiai
iaoaaieecia, a eiaiii, e nieaeaieth o?iaiy eaeueoeey e aeoeaiinoe
uaei/iie oinoaoacu a nuai?ioea e?iae, e e i?iyaeaieth aenoieiae/aneeo
i?eciaeia inoaiaeeno?ioee oaea /a?ac 6 iaaeaeue iinea iia?aoeee. A
?acoeueoaoa ea/aiey iia?e?iaaiiuo e?un yno?iaai-aanoaaaiiuie eiiieaenaie
e i?aia?aoaie eaeueoeey a oa/aiea 6 iaae. auyaeaia ii?iaeecaoeey
aeioeie/aneeo iieacaoaeae einoiiai ?aiiaeaee?iaaiey, a ii aeaiiui
aenoieiae/an-eiai enneaaeiaaiey — ni/aoaiea i?eciaeia oia?aiii
au?aaeaiiie inoaiaeeno?ioee n aeoeaii oaeoueie i?ioeannaie
iiaiia?aciaaiey einoiie oeaie. Iioeiaeueii yooaeoeaiie aeicie
yoeieeyno?aaeeiea aeey ei??aeoeee eaeueoeeaaiai iaiaia iinea
aeaonoi?iiiae iaa?eyeoiiee yaeyaony 0,06-0,09 iea/ae aeey e?un aanii
300±20a?., /oi a 1,5-2 ?aca ieaea, /ai iauai?eiyoay aeica, eioi?ay
eniieuecoaony aeey ea/aiey inoaiii?ica.

Eeeie/aneia iaaethaeaiea iiaeoaa?aeaeaao eciaiaiey iieacaoaeae einoiiai
iaoaaieecia, iieo/aiiua a yenia?eiaioa. Oaeaeaiea ye/ieeia a ia?aoiaeiii
aic?anoa i?eaiaeeo e i?iyaeaieth neiioiiia yno?iaaiiiai aeaoeoeeoa
cia/eoaeueii ?aiueoa, /ai o aeaiuei n eioaeoiuie ye/ieeaie yoiai aea
aic?anoa. Oae, aaaaoiiaa?ioe/aneea neiioiiu auyaeythony oaea a ia?aua
3ian. iinea iia?aoeee, o?iaaieoaeueiua oa einoiua – a oa/aiea ia?aiai
aiaea iinea iaa. Eo noaiaiue e a?aiy aicieeiiaaiey caaeneo io oiai, auee
i?iiia?e?iaaiu aeaiueiu a i?a- eee iinoiaiiiaoca, io iaee/ey
yeno?aaaieoaeueiie iaoieiaee. ”A?oiio ?enea” ii ?aiiaio aicieeiiaaieth
eciaiaiee a iaoaaieecia einoiie oeaie ninoaaeytho aeaiueiu n
yeno?aaaieoaeueiie iaoieiaeae, niinianoaothuae ia?ooaieth iaiaia
eaeueoeey a i?aaiecia (?aaiaoeci, inoaioiiae?ic, naoa?iue aeeaaao,
caaieaaaiey aeaeoaei/ii-eeoa/iiai o?aeoa). Oaeoi?ii caueou io
auoaoeacaiiuo ia?ooaiee yaeyaony aee?iaay oeaiue, aaea i?ienoiaeeo
yeno?aaiiaaeaeueiia ia?aciaaiea yno?iaaiia.

Oe?o?ae/aneay eano?aoeey o aeaiuei eeeiaeoa?e/aneiai aic?anoa /a?ac 9-11
ian. aaaeao e eciaiaieth iieacaoaeae einoiiai ?aiiaeaee?iaaiey, a
eiaiii, e nieaeaieth o?iaiy eaeueoeey (2,1490,03iiieue/e –
1,9630,04iiieue/e ii n?aaiaieth n 2,4590,07iiieue/e – 2,10,06iiieue/e a
eiio?iea), iiauoaieth aeoeaiinoe iauae uaei/iie oinoaoacu a nuai?ioea
e?iae (89,865,2U/l–94,54,13U/l ii n?aaiaieth n 61,175,1U/l – 88,577,8U/l
a eiio?iea). Ioee/ey a iiaea?oiiao naycaiu n ninoiyieai iaino?oaeueiie
ooieoeee, ia oiia eioi?ie auee i?iiia?e?iaaiu aeaiueiu (i?a- eee
iinoiaiiiaoca), n iaee/eai yeno?aaaieoaeueiie iaoieiaee.

O aeaiuei, ia?aianoeo iia?aoeee ii iiaiaeo aeia?iea/anoaaiiuo iiooieae
aioo?aiieo iieiauo i?aaiia n oaeaeaieai ye/ieeia a ia?eiaiiiaocaeueiii
aic?anoa, ioia/aii oneeaiea yno?iaaiiiai aeaoeoeeoa ia oiia
aeia?i?iaeoeoeee aiiaaeio?iiiuo ai?iiiia, /oi i?iyaeyaony aicieeiiaaieai
anao neiioiiia iinoeano?aoeeiiiiai neiae?iia, a oii /enea i?eciaeia
inoaiii?ica oaea ia i?ioyaeaiee ia?aiai aiaea iinea iia?aoeee, oiaaea
eae aac iaa iie auyaeythony /a?ac 3-5-7 eao.

Yoaeoeaiui iaoiaeii i?ioeeaeoeee ia?ooaiee einoiiai iaoaaieecia o
aeaiuei ia?aoiaeiiai aic?anoa, ia?aianoeo iia?aoeee n oaeaeaieai
ye/ieeia ii iiaiaeo aeia?iea/anoaaiiuo iiooieae aioo?aiieo iieiauo
i?aaiia, yaeyaony i?eiaiaiea iaoo?aeueiuo yno?iaai-aanoaaaiiuo
eiiieaenii a ni/aoaiee n i?aia?aoaie eaeueoeey. Eiiieaeniay ei??aeoeey
aeieaeia iacia/aoueny /a?ac 3-4 ian. iinea ia?aianaiiie iia?aoeee.
I?eiaiaiea auoaoeacaiiie oa?aiee ia i?ioyaeaiee 5-6 ian. aaaeao e
oiaiueoaieth eioaineaiinoe eee e iieiiio en/aciiaaieth
aaaaoiiaa?ioe/aneeo, o?iaaieoaeueiuo e einoiuo i?iyaeaiee, e iiauoaieth
o?iaiy eaeueoeey e nieaeaieth aeoeaiinoe uaei/iie oinoaoacu a nuai?ioea
e?iae ia oiia ii?iaeecaoeee iieacaoaeae ooieoeee
aeiioaeaii-aeiioeca?ii-ye/ieeiaie nenoaiu. Caianoeoaeueiay ai?iiiaeueiay
oa?aiey o aeaiuei n iaee?aieai aeieaeia i?iaiaeeony iiae no?iaei
iaaethaeaieai (aeiaioaeueiia enneaaeiaaiea, ianeaaeiaaiea iiei/iuo
aeaeac, oeeoieiae/aneia enneaaeiaaiea auaeaeaiee ec aeaaaeeua). Aeica
ai?iiiaeueiuo i?aia?aoia aeieaeia iiaeae?aoueny eiaeeaeaeoaeueii e
iiaeao auoue oiaiueoaia.

Eeth/aaua neiaa: eaeueoeee, eeeiaeoa?ee, iaa?eyeoiiey, inoaiii?ic,
caianoeoaeueiay ai?iiiaeueiay oa?aiey.

A?eai??aa I. A. Iniaeeaino? iieaciee?a e?noeiaiai iaoaaie?cio ? ?o
ei?aeoe?y o ae?iie ia?eiaiiiaocaeueiiai a?eo i?ney i?ney aeainoi?iiiuei?
iaa??aeoii?? (aenia?eiaioaeueii-ee?i?/ia aeine?aeaeaiiy).- ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?nth 14.01.01- aeooa?noai oa a?iaeieia?y. — Iaeanueeee
aea?aeaaiee iaaee/iee oi?aa?neoao IIC Oe?a?ie, Iaeana, 1998 ??e.

A aeaiiio aeine?aeaeaii? anoaiiaeaii, ui aeaeaeaiiy y?/iee?a o naiie
uo??a c??eiai a?eo aaaea aei ?aii?o ci?i e?noeiaiai iaoaaie?cio, a naia,
aei cieaeaiiy ??aiy eaeueoe?th oa aeoeaiino? eoaeii? oinoaoace, ? aei
i?iyao a?noieia?/ieo iciae inoaiaeeno?io?? aaea /a?ac 6 oeaei?a i?ney
iia?aoe??. Iioeiaeueii aoaeoeaiith aeicith ao?i?eano?aae?ieo aeey
ei?aeoe?? eaeueoe??aiai iai?io i?ney aeainoi?iiiuei? iaa??aeoii?? ?
0,06-0,09 iea/ae aeey uo??a aaaith 300±20a., ui a 1,5-2 ?ace ieae/a,
i?ae caaaeueiii?eeiyoa aeica, yea aeei?enoiao?oueny aeey e?eoaaiiy
inoaiii?ico.

Ee?i?/ia niinoa?aaeaiiy i?aeoaa?aeaeo? ci?io iieaciee?a e?noeiaiai
iaoaaie?cio (iaea?eueo ?ioi?iaoeaiei ? cieaeaiiy ai?noo eaeueoe?th,
i?aeaeuaiiy aeoeaiino? eoaeii? oinoaoace a ne?iaaooe? e?ia?), iineeaiiy
a?iiano?iaai?cio oa i?aeaeuaiiy i?iaeoeoe?? aiiaaeio?iiieo ai?iii?a, ui
i?iyaey?oueny aeieeiaiiyi on?o neiioii?a iinoeano?aoe?eiiai neiae?iio, a
oiio /ene? iciae inoaiii?ico aaea i?ioyaii ia?oiai ?ieo i?ney iia?aoe??,
oiae? ye aac ia? aiie aeyaeythoueny /a?ac 3-5-7 ?ie?a. ?aii?
eiia?iiaaia i?ecia/aiiy cai?nii? ai?iiiioa?ai?? c i?aia?aoaie eaeueoe?th
i?ney o??o?a?/ii? eano?aoe?? a ia?e- oa iinoiaiiiaocaeueiiio a?oe?
ni?ey? ii?iae?caoe?? iieaciee?a e?noeiaiai iaoaaie?cio, ciaioo?
?ioaineai?noue neiioii?a iinoeano?aoe?eiiai neiae?iio aai aaaea aei ?o
iiaii? ?aa?an?? ? iiia?aaeaeo? inoaiii?ic.

Eeth/ia? neiaa: eaeueoe?e, ee?iaeoa??e, iaa??aeoii?y, inoaiii?ic,
cai?nia ai?iiiaeueia oa?ai?y.

Grygoreva N.V. Peculiarities of indexes of bones metabolism
and their correction of perimenopausal age women after bilateral
ovaryectomy (experimental-clinical investigation).- Manuscript.

These is scientific degree of Candidate of Medical Science by speciality
14.01.01- obstetrics and gynecology. — Odessa State Medical University.
Ukrainian Ministry of Public Health.Odessa.1998.

The present study had settled, that ovaryectomy in female rats leads to
early alteration of bones metabolism, just exactly decreasing of calcium
and alkaline phosphatase levels and to appearing of histological signs
of osteodystrophy just in 6 weeks after operation. The most effective
dose of ethynilestradiol for correction of calcium metabolism after
bilateral ovaryectomy is 0.06-0.09 mcg/d for rats of 30020g weight, that
is 1.5-2 times less, then the dose, that is being used for treatment of
osteoporosis according to literatures data.

Clinical investigation confirmed alteration of the indexes of bones
metabolism (the most informative was decreasing of calcium contens,
increasing of alkaline phosphatase level in serum) enforcing of
hypoestrogenism and increasing of gonadotropic hormones secretion, that
result in appearing of all the signs of postcastration
syndrome,including the signs of osteoporosis during the first year after
operation, where as without operation they appear 3-5-7 years later.
Early combination of hormonal replacing therapy and calcium
preparations after surgical castration while peri- and postmenopausal
age promotes normalisation of the indexes of bones metabolism,
decreases the intensity of the signs of postcastration syndrome or
regresses them completely and prevents appearing of osteoporosis.

Key words: calcium, climacteric period, ovariectomy, osteoporosis,
hormonal replacing therapy.

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