Особливості гормональної регуляції водно-електролітного гомеостазу на окремих етапах постнатального розвитку: Автореф. дис… канд. мед. наук / О.М. В

OA?EIANUeEEE AeA?AEAAIEE IAAeE*IEE OIIAA?NEOAO

Aieioei Ieaenaiae? Ieeieaeiae/

OAeE 612.062-46-014.461:57.017.64

INIAEEAINOI AI?IIIAEUeII? ?AAOEssOeI? AIAeII-AEAEO?IEIOIIAI AIIAINOACO
IA IE?AIEO AOAIAO IINOIAOAEUeIIAI ?ICAEOEO

14.03.03 — ii?iaeueia oiciieiaiy

(iaaee/ii iaoee)

A A O I ? A O A ? A O

aeena?oaoei? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Oa?eia — 1999 ?ie

Aeena?oaoei?th ? ?oeiien

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oiiaa?neoaoi IIC
Oe?a?ie

Iaoeiaee ea?iaiee: Aeieoi? iaaee/io iaoe, i?ioani? Eiia??aoeaaa I?eia
Ieaenaiae?iaia. Eoaainueeee aea?aeaaiee iaaee/iee oiiaa?neoao,
aee?aeoi? iaoeiai-aeineiaeiiai oeaio?o.

Iaoeiaee eiinoeueoaio: Aeieoi? iaaee/ieo iaoe, i?ioani? Aacea?aaaeiee
Ai?en Ieaenieiae/. Eoaainueeee aea?aeaaiee iaaee/iee oiiaa?neoao,
caa?aeoaa/ eaoaae?ith ainiioaeueii? iaaeiao?i?.

Ioioeieii iiiiaioe:

Aeieoi? iaaee/ieo iaoe, i?ioani? Ee?e/ie Ethaeieea O?ioei?aia.

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?ith
oa?iaeieia??;

Aeieoi? iaaee/ieo iaoe, i?ioani? Ia?oiiaiei Ethaeieea Einoyioei?aia.

Oa?e?anueeee ?inoeooo oaeineiiaeaiiy e?ea??a, caa?aeoaa/ eaoaae?ith
o?c?ieia??, iaoieia?? ? oa?ai?? i?aee?oeiaiai a?eo.

I?iaiaeia onoaiiaa:

?inoeooo o?c?ieia?? ?i. I.I.Aiaiiieueoey, a?aeae?e o?c?ieia??
e?iaiia?ao, IAI Oe?a?ie, i.Ee?a.

Caoeno aiaeaoaeaoueny «25» ethoiai 1999 ?. ia 1100 aiaeei? ia caniaeaiii
niaoeiaeiciaaii? a/aii? ?aaee Ae 64.600.03 Oa?eianueeiai aea?aeaaiiai
iaaee/iiai oiiaa?neoaoo (310022, i.Oa?eia, i?.Eaiiia,4)

C aeena?oaoei?th iiaeia iciaeiieoenue o aiaeiioaoei Oa?eianueeiai
aea?aeaaiiai iaaee/iiai oiiaa?neoaoo (310022, i.Oa?e?a, i?.Eai?ia,4)

Aaoi?aoa?ao ?icineaiee 23 n?/iy 1999 ?.

A/aiee nae?aoa?

niaoeiaeiciaaii? a/aii? ?aaee __________________ e.a.i. E.I.AEoa??eiaa

ANOOI

Aeooaeueiinoue oaie

Aeey ?aiiueiai iinoiaoaeueiiai iioiaaiaco oa?aeoa?ii nooo?ai iniaeeainoi
aiaeii-aeaeo?ieioiiai aaeaino, yei iaoiiaeaii, ianaiia?aae,
ii?oiooieoeiiiaeueiith iac?ieinoth ie?ee, a oaeiae iecueeith ??
/ooeeainoth aei aoii?aeueieo ?aaoeyoi?ieo oaeoi?ia (Yeaainii I.A.,
1994). Iioeiaeueiee ia?aaia aaeaioeaieo ?aaeoeie o iiaiia?iaeaeaii?
aeeoeie a cia/iie ii?i aecia/a?oueny noaiii iiii- oa aiethii?aaoeyoei?
(Aioiiia A.A. e niaao., 1984). A ie?eao i?iaeoeothoueny ai?iiie ?
ai?iiiiiiaeiaii ?a/iaeie, ui aieeaathoue ia ia?a?iciiaeie ?iaeeie a
i?aaiicii, noaeeiiee oiion, a oaeiae ia iioaineaiinoue aene?aoei?
aeaeo?ieioia. Aiaeii/an iniiaii ie?eiai i?ioeane ciaoiaeyoueny iiae
eiio?ieai aaeeei? eieueeinoi aeno?a?aiaeueieo ai?iiiaeueieo oaeoi?ia
(Iaeiaaoeeay A.A. e niaao.,1994; Iaoi/ei TH.A., 1988). I?e oeueiio
ae?aiacii eiiiainaoi?ieo iiaeeeainoae i?aaiicio ciaoiaeeoueny a
aaciina?aaeiie caeaaeiinoi aiae nooiaiy ae?aaeaiino? i aeeiaii/iinoi
ia?aoai?thaaeueieo i?ioeania a nenoaii aiaeii-aeaeo?ieioiiai aiiainoaco.

Aiaeiii, ui ?aiii-aiaiioaicei-aeueaeinoa?iiiaa nenoaia (?AAN) i
i?inoaaeaiaeeie (IA) iathoue aeoaea aaaeeeaa cia/aiiy aeey
caaacia/aiiy noaaieueiinoi aioo?ioiueiai na?aaeiaeua i?aaiicio (Aea
Eetha I.A., 1997; Iaeiaaoeeay A.A. e niaao., 1994; Gothberg G.,1994). O
ca’yceo c oeei aeeeeea? iioa?an aeineiaeaeaiiy aieiaeo iniaeeainoae
noaiiaeaiiy ?o ooieoeiiiaeueii? aeoeaiinoi.

Ia ?aiiio aoaiao iioiaaiaco a oiiaao iioaineaiiai ?inoo inio?
iaiaoiaeiinoue a iiceoeaiiio aaeaini aaaaoueio ?a/iaei, a oiio /enei i
iao?ith, yeee ? aaaeeeaei oiii/iei aeaiaioii iicaeeioeiiiai i?inoi?o
(Aeeioaa A. e niaao.,1981). C o?aooaaiiyi oiai, ui o aeioae i iieiaeeo
oaa?ei ?aiaeueii oieueo?aoeieii-?aaani?aoeieii iaoaiicie ua
iaaeineiiaei, aeieea? iaiaoiaeiinoue aeyaeaiiy aeiaeaoeiaeo oaeoi?ia,
aeiy yeeo aoea a ni?yiiaaia ia cao?eieo cacia/aiiai aeaeo?ieioo a
i?aaiicii, ui ?icaeaa?oueny. A oeueiio ieaii i?eaa?oathoue oaaao
iiii?aeii iaioeaee, yei aieiaeithoue oe?ieei niaeo?ii oiciieiai/ieo
aoaeoia, aenooiath/e a yeinoi iiaeoeyoi?ia aiaeie?eiieo ooieoeie
(Inaae/ee I.A. e niaao.,1998; Iaca?iaa O.E. e niaao., 1993; Aeciai ?.E.
e niaao.,1993; I?aayi N.?., 1993).

Caiaeii e?oa?aoo?iei aeaiei, iaoaiicie ai?iiiaeueii? ?aaoeyoei? ie?eiaeo
ooieoeie o caei?iaeo aeioae a iaiiaoaeueiiio ia?iiaei aea/aii
iaaeinoaoiuei. I?iaaaeaii aeineiaeaeaiiy aenaioeththoue ooieoeiiiaeueio
aeoeaiinoue oeeo iaoaiiciia ia?aaaaeii i?e ?iciiiaiioieo iaoieiai/ieo
noaiao iiaiia?iaeaeaieo (Niiyi I.I., 1996; Eoeeia E.E. e niaao., 1994;
acea?aaaeiee A.I.,1993). Aiaeii/an i?aeoe/ii iaae?ioaiei caeeoa?oueny
ieoaiiy i?i ?iaaiue oa ni?yiiaaiinoue aca?iiaei? ie?aieo eaiie
?aaoeyoi?iiai eiiieaeno aiaeii-aeaeo?ieioiiai aiiainoaco a “e?eoe/ii”
ia?iiaee ?icaeoeo caei?iaeo ae?oae. Iaaaaeaii a?aoiaioe noaee
ia?aaeoiiaith aeey i?iaaaeiiy aeanieo eeiii/ieo oa aenia?eiaioaeueieo
aeineiaeaeaiue. Iaa?oiooaaiiyi ?o ii?aeiaiiy ? oie oaeo, ui a
iioiaaiaci ethaeeie e aenia?eiaioaeueieo oaa?ei iniothoue caaaeueii
caeiiiii?iinoi noaiiaeaiiy nenoaie aiaeii-aeaeo?ieioiiai aiiainoaco
(Aeeioaa A. e niaao.,1981).

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie

Iiaeaia ?iaioa aeeiiaia a iaaeao eiieo?nii? aea?aeathaeaeaoii? oaie IIC
Oe?a?ie — “Aiaeiaaiii iiii?aee oa aoii?aeueia eaiea ooieoeiiiaeueii?
aaeaioaoei? ie?ie a ?aaoeyoei? a?oa?iaeueiiai oeneo i
aiaeii-aeaeo?ieioiiai aaeaino i?e anaioeiaeueiie aiia?oaici? oa ie?eiaie
iaoieiai?”, a oaeiae ieaiiai? aea?aeathaeaeaoii? oaie
iaoeiai-aeineiaeiiai oeaio?o Eoaainueeiai aea?aeaaiiai iaaee/iiai
oiiaa?neoaoo (EAeIO) — “Aieea aeieiai/ii iani?eyoeeaeo oaeoi?ia ia
i?aaiici a oiiaao i?iieneiaiai ?aaiiio i ?ic?iaea iaoiaeia ei?aeoei?
iaoaaieicio oa iioaineaii? oa?aii?”.

Iaoa i caaea/i aeineiaeaeaiiy

Iaoa ?iaioe: Aecia/eoe noai oiciieiai/ii? iioaa?aoei? eiiiiiaioia
?aiii-aiaiioaicei-aeueaeinoa?iiiai?, i?inoaaeaiaeeiiai? i iiii?aeii?
nenoai a i?ioeani ?aaoeyoei? aiaeii-aeaeo?ieioiiai aiiainoaco ia
ie?aieo aoaiao iinoiaoaeueiiai ?icaeoeo.

Aeey ?aaeicaoei? iaoe iinoaaeaii ianooiii caaea/i:

1.Aeineiaeeoe aeoeaiinoue ?aiiio ieacie (A?I) i eiioeaio?aoeith
aeueaeinoa?iio ieacie (EAI) o aeioae a ?aiiueiio iaiiaoaeueiiio
ia?iiaei.

2.Aeyaeoe noai ieaciiaiai ?iaiy IAA2 ? IAF2? o aeioae i?ioyaii ia?oiai
oeaeiy iicaoo?iaiiai aeeooy.

3.Anoaiiaeoe ni?yiiaaiinoue oiciieiai/ieo aoaeoia aeineiaeaeaieo o
iiaiia?iaeaeaieo aoii?aeueieo ?aaoeyoi?ieo oaeoi?ia o aiaeiioaiii
?aiaeueieo aene?aoi?ieo iieacieeia (aeio?ac, iao?ieo?ac, eaeieo?ac).

4.C’ynoaaoe oa?aeoa? ei?aeyoeieieo aca?iica’yceia iiae ieaciiaeie IA i
eiiiiiaioaie ?AAN a i?ioeani ?aiiuei? iaiiaoaeueii? aaeaioaoei?.

5.Aea/eoe o iioaeoieo oaa?ei iioiaaiaoe/ii iniaeeainoi aiaeiaaiiiai
aiineioaco ie?eiaeo IAA2 ? IAF2?, a oaeiae oa?aeoa? aieeao oeeo ?a/iaei
ia A?I, ?aiaeueiee o?ainii?o aiaee oa aeaeo?ieioia.

6.Aecia/eoe o iioaeoieo oaa?ei ?iciiai aieo aiino iao?iiii-aieaoaeiio
(IAIE) a aiiioaeaioni, aiiioici e ieacii e?iai.

7.Ia iiaenoaai aenia?iaioaeueio aeineiaeaeaiue c’ynoaaoe ni?yiiaaiinoue
oa nooi?iue ?aaoeyoi?ieo aoaeoia IAIE a nenoaii aiaeii-aeaeo?ieioiiai
aiiainoaco.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoaoia

Aia?oa ia aeinoaoiueiio eeiii/iiio iaoa?iaei i?iaaaeaii eiiieaenia
aeineiaeaeaiiy aca?iiaei? ai?iiiaeueieo oaeoi?ia aiaeii-aeaeo?ieioiiai
aiiainoaco o caei?iaeo aeiiioaieo iiaiia?iaeaeaieo aeioae a aeeiaiioei
?aiiueiai iaiiaoaeueiiai ia?iiaeo. Ia?aeaeueii aecia/aia aoaeoeaiinoue
aieeao oeeo oaeoi?ia ia ?aiaeueiee o?ainii?o aiaee, iao?ith oa eaeith.
Aeyaeaii cia/aiiy ieaciiaeo eiiiiiaioia ?AAN i ipinoaaeaiaeeiiai? nenoai
aiaeia?aaeothoue noai aoii?aeueii? iiii- oa aiethii?aaoeyoei? i
?icaeyaeathoueny a yeinoi ii?iaoeaieo iieacieeia oiciieiai/iiai ia?aaiao
i?ioeania ?aiiuei? iaiiaoaeueii? aaeaioaoei?.

A oiaei aenia?eiaioo caeieniaii iiaeaeueoa aea/aiiy o/anoi ?aiaeueieo
IAA2 i IAF2? a ?aaoeyoei? aiaeii-aeaeo?ieioiiai aaeaino ia ie?aieo
aoaiao iinoiaoaeueiiai ?icaoeo. Aeyaeaia aioeaeio?aoe/ia oa
aioeiao?ieo?e/ia ni?yiiaaiinoue aei? aiaeiaaiiiai IAIE, yea iniaeeai
ae?aaeaia a “e?eoe/ii” ia?iiaee ?icaeoeo oaa?ei. Aia?oa io?eiaii
eiiieaenii aiaeiiinoi i?i oa?aeoa? aca?iica’yceo i?inoaaeaiaeeiiai?,
?aiii-aiaiioaiceiiai? nenoai oa IAIE a aeeiai?oei iinoiaoaeueiiai
iioiaaiaco.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoaoia

?acoeueoaoe aeineiaeaeaiiy aca?iiaei? aoii?aeueieo ?aaoeyoi?ia
aiaeii-aeaeo?ieioiiai aaeaino o iiaiia?iaeaeaieo aeioae a ?aiiueiio
iaiiaoaeueiiio ia?iiaei aeicaieythoue iioe?eoe oyaeaiiy i?i
coiiaeaiinoue i niaoeeoieo aaeaioaoeieieo i?ioeania ia oeueiio aoaii
?icaeoeo. Aeniea aeeiaii/iinoue o aeioae ia ia?oiio oeaeii iicaoo?iaiiai
aeeooy oaeeo iieacieeia, ye A?I, EAI, ieaciiaee ?iaaiue IAA2 i IAF2?,
aeicaiey? aaaaeaoe ?o aeniei iioi?iaoeaieie ia?ea?aie
eiiiainaoi?ii-i?enoinoaaeueieo iiaeeeainoae iac?ieiai i?aaiicio. Oei
iieacieee iiaeooue aooe aoaeoeaii aeei?enoaii aeey aecia/aiiy nooiaiy
iai?oaeaiino? i?ioeania ?aiiuei? iaiiaoaeueii? aaeaioaoei?,
nai?/anii? i?ioieaeoeee c?eao aaeaioaoei?, aeiaaiinoeee oyaeeinoi
noaio oai?i? aeeoeie i iiaeaeueoiai i?iaiico.

Aenia?eiaioaeueii aeaii i?i ni?yiiaaiinoue oiciieiai/ieo aoaeoia IAIE
aiaee?eaathoue ia?niaeoeao aeey aeyaeaiiy o iiaiia?iaeaeaieo aeioae
?aaoeyoi?ieo iaoaiiciia, yei iaee a aaaeeeaa cia/aiiy aeey caaacia/aiiy
aiaeii-aeaeo?ieioiiai aiiainoaco a oiiaao ?aiiuei? iaiiaoaeueii?
aaeaioaoei?.

?acoeueoaoe aeineiaeaeaiue ai?iaaaeaeaii o i?aeoeeo Eoaainueeiai
oeaio?o ioi?iie iaoa?einoaa i aeeoeinoaa, a oaeiae aeei?enoiaothoueny a
o/aiaiio i?ioeani i?e iiaeaioiaoei nooaeaioia, eiea?ia-noai?aeeiaoi?ia
oa iioa?iia-iaiiaoieiaia ia eaoaae?ao iaaee/ii? oiii?, ii?iaeueii?
oiciieiai? i ainiioaeueii? iaaeiao?i? EAeIO.

Iniaenoee aianie caeiaoaa/a

Aianie aaoi?a i?e aeeiiaiii aeena?oaoeieii? ?iaioe ? iniiaiei. Aii
iieyaa?, ianaiia?aae, o naiinoieiiio aeeiiaiii iaeyaeo e?oa?aoo?e,
oi?ioaaiii a?oi niinoa?aaeaiiy, eeiii/iiio niinoa?aaeaiii ca
iiaiia?iaeaeaieie aeioueie, o/anoi o iaai?i eeiii/iiai oa
aenia?eiaioaeueiiai iaoa?iaeo, noaoenoe/iie ia?iaoei oa iioa?i?aoaoei?
io?eiaieo ?acoeueoaoia, a oaeiae o oi?ioethaaii? aeniiae?a ?iaioe.
Noaooi, ui iioaeieiaaii o niiaaaoi?noai a aeo?iaei “Iae?ioeceieiaey” i
“Oe?aeineii aeioeie/aneii aeo?iaea” iinoyoue iaea?aeaii caeiaoaa/ai
?acoeueoaoe, yei oi?eathoueny aiaeiiaiaeii aenia?eiaioaeueieo
aeineiaeaeaiue IAIE i eeiii/ieo aeineiaeaeaiue A?I i EAI. A iaeyaeiaie
noaooi, iioaeieiaaiie o niiaaaoi?noai a aeo?iaei “Ainiee iaoeiaeo
aeineiaeaeaiue”, iei i?iaaaeaii ocaaaeueiaiiy eioa?aoopieo aiaeiiinoae
ca aea/aiith oaiith, a oaeiae aecia/ai? eeth/ia? iieiaeaiiy ?iaioe.

Ai?iaaoeiy ?acoeueoaoia aeena?oaoei?

?acoeueoaoe ?iaioe aoee ?icaeyiooi e iaaiai?aii ia niieueiiio caniaeaiii
niia?iaioieeia iaoeiai-aeineiaeiiai oeaio?o i eaoaae?e ainiioaeueii?
iaaeiao?i? EAeIO (1998 ?.). Iniiaii ?? iieiaeaiiy iiaiaeiieaii ia
iaoeiaie eiioa?aioei? i?enay/aiie 40-?i//th EAeIO (1996 ?.),
iiaenoieiaeo iaoeiaeo eiioa?aioeiyo iieiaeeo a/aieo oa nooaeaioia EAeIO
(1995-1997 ?.?.), caniaeaiiyo Eoaainueeiai iaeaniiai iaoeiaiai
oiaa?enoaa aeeoy/eo eiea?ia i iaiiaoieiaia (1994-1997 ?.?.).

Ioaeieaoei?

Ca iaoa?iaeaie aeena?oaoei? iioaeieiaaii 7 ?iaio, ?c yeeo 4 — o oaoiaeo
iaoeiaeo aeaeaiiyo (“Iae?ioeceieiaey”, “Iaaee/ii ia?niaeoeae”, “Ainiee
iaoeiaeo aeineiaeaeaiue”), 1 – a “Oe?aeineii aeioeie/aneii aeo?iaea”,
i 2 — o cai?eao iaoeiaeo i?aoeue.

No?oeoo?a i ia’?i aeena?oaoei?. Aeena?oaoeiy aeeeaaeaia ia 144 noi?iieao
iaoeiiieniiai oaenoo i neeaaea?oueny ci anooio, iaeyaeo eioa?aoo?e,
iieno iaoa?iaeia oa iaoiaeia aeineiaeaeaiiy, 4 ?icaeieia aeanieo
aeineiaeaeaiue, caeeth/iiai iaaiai?aiiy iaea?aeaieo ?acoeueoaoia oa
aeniiaeia. Nienie aeei?enoaii? aio/eciyii? oa iiicaiii? eioa?aoo?e
aeeth/a? 271 aeaea?aei. ?iaioa iethno?iaaia 20 oaaeeoeyie, 11
aeiaa?aiaie oa iaei??th aeieneith ic inoi?i? ?icaeoeo iiaiia?iaeaeaii?
aeeoeie.

CIINO ?IAIOE

Ia’?eoe i iaoiaee aeineiaeaeaiiy. ?aaeicaoeiy iaoe i iinoaaeaieo caaea/
caeienithaaeany oeyoii eeiii/ieo oa aenia?eiaioaeueieo aeineiaeaeaiue. A
oiaei aeeiiaiiy eeiii/ii? /anoeie ?iaioe ianoaaeaii 108 caei?iaeo
aeiiioaieo iiaiia?iaeaeaieo aeioae a aeeiaiioei ?aiiueiai iaiiaoaeueiiai
ia?iiaeo. Caaaeueiee noai aeioae i?ioyaii onueiai ia?iiaeo
niinoa?aaeaiiy caeeoaany caaeiaieueiei. Ani aiie ciaoiaeeeeny ia
i?e?iaeiiio aeaiaeiaoaaiii. Eeiii/ii i?iyae o?aiceoi?ieo noaiia, yei
ia’?eoeaii aiaeia?aaeathoue ia?aaia i?ioeania aaeaioaoei?
iiaiia?iaeaeaieo aei iicaoo?iaiiai aeeooy, ciaoiaeeeeny a iaaeao
caaaeueiii?eeiyoi? oiciieiai/ii? ii?ie.

Iaoa?iaeii eeiii/ieo aeineiaeaeaiue aoea e?ia ic ioiiaeie i aaiicia
e?ia, caa?aia o iiaiia?iaeaeaieo ic ia?eoa?e/ieo aai ia 2-3 i 6-7 aeiai
aeeooy. Ocyooy aaiicii? e?iai i?iaiaeeeiny iaeii?aciai c 10 aei 12
aiaeeie aeiy. E?ia ic ioiiaeie caae?aeany a ?iciee /an aeiae. *a?ac
iaiiaeeeainoue aaaaoi?aciaiai ocyooy e?iai aeineiaeaeaiiy i?iaiaeeeeny o
ii?iaithaaieo ca aieii a?oiao aeioae. E?ii oiai, a aeeiaiioei
niinoa?aaeaiiy o oeii/eeia aecia/aany iiaiaeeiiee aeio?ac. Cai? na/i ia
ia?o?e aeia? aeeooy i?iaiaeeany /a?ac 10-15 aiaeei iiney ia?iaeaeaiiy,
ine?eueee na/iaeaeieaiiy c’yaeyeiny o ieo oieueee c oeueiai /ano. Ia 2-3
i 6-7 aeiai aeeooy cai? na/i caeienithaaany a ?aieiaee /an iiae
aiaeoaaiiyie.

Aenia?eiaioaeueii aeineiaeaeaiiy aeeiiaii ia 68 uo?ao-naioeyo eiii?
Ainoa? 4-, 6- ? 16-oeaeiaaiai aieo a iniii?-ceiiaee ia?iiae. Oaa?eie
ciaoiaeeeeny ia cae/aeiie eaai?aoi?iie aee?oi, aac iaiaaeaiiy
aiaeii-nieueiaiai ?aaeeio, i?e oaiia?aoo?i iiaio?y +18…+20?N. Iana
oaa?ei noaiiaeea: 4-oeaeiaaeo — 44,32?1,24 a; 6-oeaeiaaeo — 98,41?2,24
a; 16-oeaeiaaeo 241,46?4,04 a. Iaoa?iaeii aeineiaeaeaiue aoea oeaieia
ie?ie, aiiioaeaiona, aiiioica, e?ia i na/a.

Eieueeinia aecia/aiiy anio aiieiai/ii aeoeaieo ?a/iaei, ui aea/aeeny a
eeiiioei e aenia?eiaioi, i?iaiaeeeiny iaoiaeii ?aaeiiiioiiiai aiaeico
iiney ?o iiia?aaeiuei? aeno?aeoei? oa eiioeaio?aoei?. Oei aeineiaeaeaiiy
aeeiiaii ca aeiiiiiaith noaiaea?oieo eiia?oeieieo iaai?ia i ciaoiaeeeeny
o iiaiie aiaeiiaiaeiinoi c i?eeeaaeaieie aei ieo iino?oeoeiyie. Aoee
aeei?enoaii iaai?e oaeeo oi?i: aeey aecia/aiiy A?I — “International-cis”
(O?aioeiy), EAI — “Sorin”(Ioaeiy), IAA2 — “Amersham” (Aiaeiy), IAF2? —
iinoeooo yaea?ieo aeineiaeaeaiue (Oai?ueia), IAIE — “Incstar” (NOA).
Iiae?aooiie ?aaeiiaeoeaiinoi i?iaiaeeee ia ei/eeueieeo “Aaiia-1”.
?iaaiue aiineioaco IA a ie?eiaie oeaieii, a oaeiae aiino IAIE a
aiiioaeaioni e aiiioici ia?a?aoiaoaaee ia 1 ia aieea oeaieie ii Eio?i.
Aeii?thaaiiy aiinoo iao?ith oa eaeith a na/i i?iaiaeeeiny ca aeiiiiiaith
aiieiai/iiai aeeaei-iie?iaiaeicaoi?a (Oai?ueia).

Ia?aeiiee oeeo?iaee iaoa?iae eeiii/ieo i aenia?eiaioaeueieo
aeineiaeaeaiue ia?iaeaiee o?aaeeoeieieie iaoiaeaie aa?iaoeieii?
noaoenoeee c aeeiiaiiyi ia?iiai ei?aeyoeieiiai oa ?aa?anieiiai aiaeicia
(Iieyeia E.A. e niaao.,1975). Aeey ioeiiee ai?iaiaeiinoi io?eiaieo
?acoeueoaoia (?) aoa aeei?enoaiee e?eoa?ie Aieeieniia-Oaeoa (W). Oei
?acoeueoaoe ?icoeiithaaeeny ye noaoenoe/ii ai?iaiaeii ca ?<0,05. ?acoeueoaoe aeine?aeaeaiiy ? ?o iaaiai?aiiy. A i?ioeani ?aaeicaoei? aaeaioaoeieieo iiaeeeainoae aeeoeie ia ii/aoeiaiio aoaii iinoiaoaeueiiai iioiaaiaco, eiee aeey iueiai oa?aeoa?ia ae?aaeaia ii?oiooieoeiiiaeueia iac?ieinoue ie?ie, aaaeeeaa ?ieue iaeaaeeoue ?AAN (Coaiae/ A.E., 1989). Aiia ia? eeth/iaa cia/aiiy o aoii?aeueiiio ?aaoeyoi?iiio eiiieaeni aiaeii-aeaeo?ieioiiai aiiainoaco, oyaeyth/e niaith ca’yceiao eaieo iiae ie?eaie, iaaeie?ieeaie, aiiioicii, na?oeaai-noaeeiiith oa oeaio?aeueiith ia?aiaith nenoaiaie (Aece? A.A. e niaao.,1998; Naeioeeoeeee A.N. e niaao.,1997; Aiiaoeeee A.A. e niaao., 1994; Goldfarb D.A., 1994). Aeineiaeaeaiiy ?AAN iieacaee, ui oa?aeoa? aeeiaii/ieo ciii cia/aiue ?? ie?aieo eiiiiiaioia o aeioae i?ioyaii ?aiiueiai iaiiaoaeueiiai ia?iiaeo aoa ?iciei (oaae.1). O ieo, ii?yae ic ai?iaiaeiei (?<0,01) iiaeaeuaiiyi A?I, aecia/aeiny oaeiae ai?iaiaeia (?<0,01) cieaeaiiy EAI. ?icia ni?yiiaaiinoue ciii A?I i EAI o iiaiia?iaeaeaieo o aeeiaiioei ?aiiueiai iaiiaoaeueiiai ia?iiaeo aea? iiaenoaao i?eionoeoe, ui ia oeueiio aoaii ?icaeoeo aioo?ioiueinenoaiia aeoeaaoeiy ?AAN ia ? ae?ioaeueiei oaeoi?ii, yeee aecia/a? ?iaaiue EAI. ?acii c oei ciiie EAI oa eiaoioei?ioa EAI/A?I, yeee aeicaiey? i?i?ioiaii ioeiithaaoe noai ?aaeoeaiinoi ei?e iaaeie?ieeia aei aiaiioaiceio oa eiai ooieoeiiiaeueio aeoeaiinoue (Ieeianeay I.A.,1991), aoee iaeiini?yiiaaieie. Neiae aiaecia/eoe, ui aeyaeaii a ianoaaeaieo iiaiia?iaeaeaieo cia/aiiy A?I i EAI a aeaeieueea ?acia ia?aaeuothoue aiaeiai/ii iieacieee o aei?ineeo (Oaaeeia ?.A. e niaao.,1993; Ei?eooei I.A. e niaao.,1991). Oea naiae/eoue i?i aenieo iai?oaeaiinoue ooieoeiiioaaiiy o ieo ?AAN. Oiciieiai/iee ciino oaeiai noaio ?AAN iieyaa?, ianaiia?aae, o caaacia/aiii oiia aeey iioeiaeueiiai ia?aaiao aaeaioaoeieieo oa aiaaiei/ieo i?ioeania o aeioae a ?aiiueiio iaiiaoaeueiiio ia?iiaei. I?e oeueiio neiae oaeiae a?aoiaoaaoe aaaeeeao eiiiainaoi?io ?ieue ?AAN a oiiaao inioth/i? o aeioae ia ii/aoeo iicaoo?iaiiai aeeooy cieaeaii? /ooeeainoi ie?eiaeo ?aoeaioi?ia aei aioeaeio?aoe/iiai ai?iiio (Aioiiia A.A. e niaao., 1984). A?aoiaoth/e aoaeoeaio o/anoue ?AAN a caaacia/aiii aiaeii-aeaeo?ieioiiai aiiainoaco i?aaiicio, ia?aeaeueii c aea/aiiyi ?? ieaciiaeo eiiiiiaioia o aeioae i?iaiaeeeiny aecia/aiiy aeayeeo ?aiaeueieo aene?aoi?ieo iieacieeia (iiaiaeeiiee aeio?ac, iao?ieo?ac, eaeieo?ac). C’ynoaaeiny, ui cia/aiiy anio oeeo iieacieeia aei iiiaioo aeienee aeioae ic iieiaiaiai aoaeeieo ai?iaiaeii caieueooaaeeny. I?e/iio iaeneiaeueia caieueoaiiy caoieniaaii aeey aeio?aco, a iiiiiaeueia - aeey o?eia?ii? aene?aoei? eaeith. ?acoeueoaoe ei?aeyoeieiiai aiaeico i?iaeaiiino?oaaee iayaiinoue iaeii/aniiai iao?ie- oa eaeiecaa?iaath/iai aoaeoia iiia?aeiei?oeei?aeo, ui iiaeoaa?aeaeo? inioaaiiy iacaeaaeieo aioo?ioiueiie?eiaeo o?ainii?oieo iaoaiiciia aeey oeeo aeaeo?ieioia (Iaoi/ei TH.A., 1988). Oaaeeoey 1 ?iaaiue ieaciiai? aeoeaiinoi eiiiiiaioia ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie o iiaiia?iaeaeaieo aeioae a ?aiiueiio iaiiaoaeueiiio ia?iiaei (M ? m) Eiiiiiaioe ?AANAie aeioaepIi/aoie 1 aeiae aeeooy, n=322-3 aeiaa aeeooy, n=326-7 aeiaa aeeooy, n=28A?I, ia/ie/aiae 2,86±0,31 3,71±0,40 8,02±1,62p1>0,05 p2<0,01 p3<0,05EAI, ia/ie1,39±0,061,23±0,061,12±0,05?1>0,05 p2<0,01 p3>0,05EAI/A?I0,64±0,060,42±0,040,20±0,02p1<0,01 p2<0,01 p3<0,01 I?eiioee: p1-ai?iaiaeiinoue ?icieoei iieacieeia i?e ia?iaeaeaiii i ia 2-3 aeiai aeeooy; p2-ai?iaiaeiinoue ?icieoei iieacieeia i?e ia?iaeaeaiii i ia 6-7 aeiai aeeooy; p3-ai?iaiaeiinoue ?icieoei iieacieeia ia 2-3 i 6-7 aeiai aeeooy. Ii?yae ?c aea/aiiyi ?AAN o aeioae i?iaiaeeeiny oaeiae aecia/aiiy aiinoo a ieacii e?iai IAA2 ? IAF2? (oaae.2). sse aiaeiii, IA neioacothoueny i?aeoe/ii a onio oeaieiao i aieiaeithoue aaeeeei ?iciiiaiiooyi oiciieiai/ieo aoaeoia, ia?aaoaath/e o oiniiio ooieoeiiiaeueiiio aca?iica’yceo c ai?iiiaie oa oeeeei/ieie ioeeaioeaeaie (Nie?iiaa A.E. e niaao., 1997; Ia?eia O.I., 1985). Caeienithth/e nooo?aee aieea a ie?eao ia ia?a?iciiaeie e?iaioiea, eeoai/eiao oieueo?aoeith, eaiaeueoeaaee o?ainii?o iiiia, i?iaeoeoe oeeeeieneaaiaco i?eeiathoue aaciina?aaeith o/anoue a ?aaoeyoei? aiaeii-aeaeo?ieioiiai aiiainoaco (Aeaii Aeae.,1987; Salaral F.J., 1995). O aeioae i?ioyaii ?aiiueiai iaiiaoaeueiiai ia?iiaeo aeyaeaii oaeeaiiaeiaiee oa?aeoa? ciiie ieaciiai? eiioeaio?aoei? IAA2. Iaeneiaeueii ?? cia/aiiy caoieniaaii ia 2-3 aeiai aeeooy. I?e ia?iaeaeaiii oa ia 6-7 aeiai aeeooy aiie aoee i?eaeecii iaeiaeiaeie. Aaaeeeai aiaecia/eoe, eaciee o aeioae noa?oeo aieiaeo a?oi (Iicaeaanueeee A.O.e niaao.,1997). Oaea ?icieoey ? aeineoue nooo?aith i oiio ia iiaea aooe iiyniaia oieueee iiaeeeainoth aeei?enoaiiy iaiaeiaeiaeo iaoiaeee i?e aecia/aiii IAA2. Oaaeeoey 2 Aeeiaiiea ieaciiai? eiioeaio?aoei? i?inoaaeaiaeei?a o iiaiia?iaeaeaieo aeioae a ?aiiueiio iaiiaoaeueiiio ia?iiaei (I ± m) IAAie aeioae ?Ii/aoie 1 aeiae aeeooy, n=302-3 aeiaa aeeooy, n=276-7 aeiaa aeeooy, n=28IAA2, ia/ie8,31±0,4213,19±0,809,79±1,13p1<0,05 p2>0,05 p3>0,05IAF2a,
ia/ie2,92±0,531,78±0,330,82±0,09p1>0,05 p2<0,01 p3<0,01IAA2/IAF2a3,73±0,359,97±1,1114,54±1,56P1<0,01 p2<0,01 p3<0,05 I?eiioee: p1-ai?iaiaeiinoue ?icieoei iieacieeia i?e ia?iaeaeaiii i ia 2-3 aeiai aeeooy; p2-ai?iaiaeiinoue ?icieoei iieacieeia i?e ia?iaeaeaiii i ia 6-7 aeiai aeeooy; p3-ai?iaiaeiinoue ?icieoei iieacieeia ia 2-3 i 6-7 aeiai aeeooy. sse c’ynoaaeiny a oiaei aeineiaeaeaiue, aeeiaii/ii ciiie ?iaiy IAF2?, ia aiaeiiio aiae IAA2, iaee iaeiini?yiiaaiee oa?aeoa?. Oae, iaeneiaeueia eiioeaio?aoeiy IAF2? aecia/aeany a ioiiaeiiie e?iai. Iai?eeiioei ia?iiaeo ?aiiuei? iaiiaoaeueii? aaeaioaoei? aiia aoea iaeieae/ith, ai?iaiaeii aiae?iciyth/enue aiae cia/aiue iieacieea, ui oienoaaeeny i?e ia?iaeaeaiii (p<0,01). A onio ianoaaeaieo a?oiao aiino IAA2 a ieacii e?iai aoa aeuei, iiae IAF2?. A eioa?aoo?i iinoyoueny aiaeiiinoi i?i oa, ui o caei?iaeo iiaiia?iaeaeaieo a ioiiaeii?e e?ia? ia? iinoea ua aieueo ae?aaeaia ia?aaaaeaiiy (a 10 ?ac?a) ieaciiaeo cia/aiue IAA2 iaae IAF2? (Nieiiaoeue I.I.oa niiaaao.,1995). Aiaeiii, ui IA ?icieo eeania, cie?aia IAA2 i IAF2?, ia?iaeei aieiaeithoue i?ioeeaaeii ni?yiiaaieie aoaeoaie. I?e/iio ?o ?acoeueooth/ee aieea ia oo /e iioo ooieoeith oyaey?oueny o aeaeyaei aeaaa?a?/ii? noie aiaiaaeaioieo aca?iiaeie (Eaoe I.Ae. e niaao., 1983). Oiio aeniei iioi?iaoeaiei iieacieeii, ui oa?aeoa?eco? aiieiai/io aeoeaiinoue aea/aieo IA i?e ?aaeicaoei? aaeaioaoe?eieo ?aaeoeie o iiaiia?iaeaeaieo, ? eiaoioei?io IAA2/IAF2?. I?ioyaii ia?iiaeo niinoa?aaeaiiy ca aeioueie aoei anoaiiaeaii iiaeaeuaiiy eiai cia/aiue a 4 ?ace. ?acoeueoaoe ia?iiai ei?aeyoeieiiai aiaeico aeyaeee iayaiinoue ai?iaiaeiiai iiceoeaiiai oa noaaieueiiai aca?iica’yceo iiae eiaoioei?ioii IAA2/IAF2? e aeio?acii. Aeoiaey/e c oeueiai, iiaeia i?eionoeoe, ui noia?iee oiciieiai/iee aoaeo aea/aieo IA a nenoaii aiaeii-aeaeo?ieioiiai iaiiio ni?yiiaaiee, a ia?oo /a?ao, ia iiaeneeaiiy o?eia?ii? aene?aoei? aiaee. A ?aooi aeiaaeeia iiae ieaciiaeie IA oa aeineiaeaeaieie aene?aoi?ieie iieacieeaie aca?iica’ycie ia anoaiiaeaii. A oeieiio, ia iiaenoaai i?iaaaeaieo ?ic?aooieia eiaoioei?ioa ei?aeyoei? ia iiaeia aeaoe iiaio ioeiieo nooiaiy ?aaoeyoi?ii? o/ano? i?iaeoeoia oeeeeieneaaiaco o caaacia/aiii aiaeii? oa iiiii? noaeinoi aioo?ioiueiai na?aaeiaeua i?aaiicio iiaiia?iaeaeaii? aeeoeie. C iaoith c’ynoaaiiy oa?aeoa?o iioaa?aoei? iaoaiiciia iiii- oa aiethii?aaoeyoei? iaie aeeiiaii oaeiae aeineiaeaeaiiy ei?aeyoeieieo i ?aa?anieieo aca?iiaiaeiinei iiae A?I oa IA. Aeyaeaii iayaiinoue aenieiai oa noaaieueiiai iiceoeaiiai aca?iica’yceo aeey IAA2. O aeiaaeeo c IAF2? a?i aoa noaoenoe/ii ai?iaiaeiei eeoa ia ia?oie aeiai aeeooy iiaiia?iaeaieo. I?ioa anoaiiaeaii cia/aiiy eiaoioei?ioia ?aa?ani? naiae/aoue i?i i?eaeecii ?iaio o/anoue iaio IA a i?ioeani iioaioeithaaiiy iiioeithth/i? eaiee ?AAN. Aiaeii/an aenieee ?iaaiue A?I, iaaii, ? iaeiei ic oaeoi?ia, ui iiaeo?eio? aoaeoeaio ?aaoeyoi?io aeith aea/aieo i?iaeoeoia oeeeeieneaaiaco, i a ia?oo /a?ao IAA2. Aiaeicoth/e iaea?aeaii ?acoeueoaoe, iaiaoiaeii a?aooaaoe, ui IA, ia aiaeiiio aiae oee?eoethth/eo ai?iiiia, iaeaaeaoue aei iinoeaaeo ?aaoeyoi?ia ooieoeie. I?e oeueiio, cae/aeii, ia aeeeeea? noiiiaia oie oaeo, ui iaeneiaeueiee aieea ia aiaeii-aeaeo?ieioiee aaeain i?aaiicio aoaeooue ni?aaeyoe ?aiaeueii IA. Aeei?enoaiee iiina?aaeeiaaiee iiaeoiae i?e ioeiioei aiiainoaoe/ieo ooieoeie IA coiiaeaiee aiaeiiith iaiiaeeeainoth aea/aiiy o caei?iaeo aeioae oeaieiiiai ?iaiy ie?eiaeo IA. Oey ianoaaeia noaea iaeiei ic a?aoiaioia ia ei?enoue ia?aoiaeo a iiaeaeueoiio aei aenia?eiaioaeueieo aeineiaeaeaiue. E?ii oiai, a aeeiaieoei niinoa?aaeaiiy ca aeioueie iaie aeyaeaii iiaeaeuaiiy eiaoioei?ioa IAA2/IAF2? i cieaeaiiy EAI. Oea, c o?aooaaiiyi aiaeiii? oiea?aioiinoi ie?ie iiaiia?iaeaeaiiai aei aioeaeio?aoe/iiai ai?iiio, iaa?oioiao? iaiaoiaeiinoue iiooeo a aenia?eiaio? ?aaoeyoi?ieo oaeoi?ia, aeiy yeeo aoea a ni?yiiaaia ia iiiiaiaiiy ao?ao c?inoath/ei i?aai?ciii aiaee i iao?ith. I, ia?aooi, aea/aiiy aca?iiaei? ?aaoeyoi?ieo iaoai?ciia aiaeii-aeaeo?ieioiiai aiiainoaco ? aieueo iioi?iaoeaiei, yeui acyoe aei oaaae, ianaiia?aae, ?o aeoeaiinoue a ie?eao, aea aaciina?aaeiuei caeieniththoueny i?ioeane iiii- oa aiethii?aaoeyoei?. O aiaeiiaiaeiinoi c iinoaaeaieie caaea/aie ia?oee aoai aenia?eiaioaeueieo aeineiaeaeaiue iieyaaa o aeyaeaiii iioiaaiaoe/ieo iniaeeainoae aiaeiaaiiiai aiineioaco IA a ie?eiaie oeaieii o aca?iica’yceo c aeayeeie iieacieeaie aene?aoi?ii? oa iie?aoi?ii? ?aiaeueii? ooieoei?. Anoaiiaeaii, ui o oaa?ei onio aieiaeo a?oi eiioeaio?aoeiy IAA2 oa IAF2? a ie?eiaie iaaeoei aoea iaaaaaoi aeuith, iiae a ei?i (p<0,01). I?e oeueiio oa?aeoa? aieiaeo ciii ii eiaeiiio ic aea/aieo IA iaa nai? iniaeeainoi. Oae, aiaeiaaiac IAA2 a iiceiaiio oa?i i?ioyaii ia?iiaeo niinoa?aaeaiiy ciaoiaeeany i?aeoe/ii ia iaeiiio ?iaii (p>0,05). Aiaeii/an aiino iaaeoey?iiai IAF2? o 16-oeaeiaaeo uo?ia
(9,38±1,05 ia/ia aieea) o ii?iaiyiii c oaa?eiaie iieiaeoiai aieo
cieaeoaaany aieueoa iiae a 2 ?ace (p<0,01). A ei?oeeaeueiiio oa?i i?iaeoeoeiy IAA2 aoea iaeaeuith o 4-oeaeiaaeo uo?ia (225,71?20,70 ia/ia aieea) i ai?iaiaeii cieaeoaaeany o oaa?ei iioeo aieiaeo a?oi (p<0,01). Uiaei ei?oeeaeueiiai aiineioaco IAF2?, oi eiai iaeneiaeueiee ?iaaiue aeyaeaii o 6-oeaeiaaeo oaa?ei (113,80?8,91 ia/ia aieea), yeee ai?iaiaeii aiae?iciyany aiae cia/aiue, caoieniaaieo o uo?ia aieii 4 i 16 oeaeiia (p<0,01). Aeeeeeathoue iioa?an aieiai aiaeiiiiinoi eiaoioei?ioa IAA2/IAF2?. A iiceiaiio oa?i ie?ee aii ai?iaiaeii caieueooaaany o 16-oeaeiaaeo uo?ia (?<0,01). A ei?oeeaeueiiio oa?i, iaaiaee, eiai cia/aiiy o 4-oeaeiaaeo uo?ia ia?aaeuoaaee oaei o oaa?ei noa?oiai aieo i?eaeecii a 4-5 ?acia. Aeyaeaia a aeeiaiioei i?ioeeaaeia ni?yiiaaiinoue niiaaiaeiioaiiy IAA2/IAF2? a ?icieo oeaieiieo ciiao ie?ee aeicaiey? i?eionoeoe, ui ?acoeueooth/ee ?aaoeyoi?iee aoaeo oeeo IA ia nenoaio aiaeii-aeaeo?ieioiiai iaiiio a iioiaaiaci aoaea ciiithaaoeny. Ia?aeaeueii ?c aea/aiiyi ie?eiaiai aiineioaco IA o oaa?ei i?iaiaeeeiny aecia/aiiy ?iaiy aene?aoei? IAA2 ? IAF2? c na/ath. sse c’ynoaaeiny, a iioiaaiaci oeae iieaciee ai?iaiaeii cieaeoaaany aeey iaio IA (p<0,01). Aiaeii/an oaiie i ni?yiiaaiinoue aieiaeo ciii eiaoioei?ioa IAA2/IAF2? a ie?eiaeo ciiao ? na/? aoee aiaeiiiieie. Aenia?eiaioaeueii aeineiaeaeaiiy aeeth/aee oaeiae aecia/aiiy o oaa?ei a iioiaaiaci A?I. Aiaeiii, ui aaee/eia oeueiai iieacieea a cia/iie ii?i caeaaeeoue aiae noaio ie?eiaiai neioaco ?aiiio (Aea Eetha I.A., 1997). Iaeneiaeueii cia/aiiy A?I aeyaeaii o uo?ia aieii 4 oeaeii (5,47?0,49 ia/ie/aiae) i 6 oeaeiia (5,76?0,52 ia/ie/aiae), yei, ye aeaeii, aoee i?aeoe/ii iaeiaeiaeie. ?acii c oei ?yae aaoi?ia iaaiaeeoue aeaii i?i oa, ui cia/aiiy A?I o oaa?ei aieii 4 oeaeii aoee aeueie o 2 ?ace o ii?iaiyiii ?c 6-oeaeiaaeie (Eo/a?aiei A.A.e niaao., 1986). O 16-oeaeiaaeo oaa?ei cao?eniaaii ai?iaiaeia cieaeaiiy A?I (1,36?0,21 ia/ie/aiae; p<0,01). A oiaei aenia?eiaioo aoei i?iaaaeaii aeineiaeaeaiiy oa?aeoa?o ei?aeyoeieiiai aca?iica’yceo iiae A?I oa ?iaiai aiineioaco ie?eiaeo IA. I?iaeaiiino?iaaia aeineoue aeniea iiceoeaia neea ei?aeyoei? aeey IAA2 o oaa?ei onio aieiaeo a?oi ye o iaaeoei, oae i a ei?i (r= aiae +0,63 aei +0,84; ?<0,05). Aiaeii/an aeey iaaeoey?iiai i ei?oeeaeueiiai IAF2? iiceoeaiee aca?iica’ycie c A?I aoa ai?iaiaeiei oieueee o 6-oeaeiaaeo uo?ia, ui na?ae/eoue i?i inioaaiiy oinii? iioaa?aoei? iiae cacia/aiei IA i ?aiii-aia?ioaiceiiaith nenoaiith a ia?iiae noaoaaiai aeic?iaaiiy. ?acoeueoaoe ?aa?an?eiiai aiaeico iiaeoaa?aeaeothoue iayaiinoue iiae ?aiiiii i IA aca?iiiai iioaioethth/iai aieeao. I?e oeueiio aeyaey?oueny aeiiiioth/a cia/aiiy IAA2 a i?ioeani eiio?ieth ooai?aiiy ?aiiio. Aeey c’ynoaaiiy ni?yiiaaiinoi aieeao IA ia nenoaio aiaeii-aeaeo?ieioiiai iaiiio o uo?ia ?iciiai aieo, ii?yae ?c ?o aeineiaeaeaiiyi a oeaieii ie?ie i na/i, oaeiae aecia/aeeny aeayei ?aiaeueii aene?aoi?ii iieacieee (aeio?ac, o?eia?ia aene?aoeiy iao?ith i eaeith). Aoei aeyaeaii, ui aaniethoii cia/aiiy onio cacia/aieo iieacieeia c aieii caieueooaaeeny, aeinyaath/e iaeneiaeueieo oeeo? o 16-oeaeiaaeo uo?ia. Iaeiae i?e ia?a?aooieo ia 100 a iane oaa?ei i?iaeaiiino?iaaiee aeiaiao?aeueii i?ioeeaaeiee oa?aeoa? ?o aieiai? aeeiaiiee. Aeineiaeaeaiiy ei?aeyoeieiiai aca?iica’yceo iiae o?eia?ieie IAA2 i IAF2?, c iaeiiai aieo, oa iieacieeaie aene?aoi?ii? ooieoei? ie?ie, c ae?oaiai, naiae/eoue i?i oa, ui oei IA aieiaeithoue iao?ie- i aeio?aoe/ieie aoaeoaie, noaaieueieie i?ioyaii onueiai ia?iiaeo niinoa?aaeaiiy. I?iaeaia noaiiaeaiiy a iioiaaiaci ai?iiiaeueii? ?aaoeyoei? ooieoeie ioiieth? ieoaiiy oi?ioaaiiy ie?aieo eaiie iae?iaiaeie?eiii? nenoaie, a oaeiae ?icaeoeo iiae ieie oinieo aca?iiaiaeiinei. Naii iae?iaiaeie?eiii ?aaoeyoi?i? iaoaiicie neiae ?icaeyaeaoe ye aeia?a aiaeeaaiaeaeaio neeaaeio nenoaio noiiae?yaeieo i aca?iii eiio?ieueiaaieo eaiie, a yeie iioeiaeueii niieo/a?oueny aiaeiinia aaoiiiiiy i naii?aaoeyoeiy ieae/eo ?iaiia c oeaio?aeiciaaiei ea?oaaiiyi c aieo aeueo aiaeaeieia. Oey noiiae?yaeiinoue oa aca?iicaeaaeiinoue iaeaieueo yne?aai i?iyaey?oueny ca oeo noaiia, eiee aeieeath/i aeno?aii iio?aae noaaeyoue iiaeaeuaii aeiiae aei aeoeaiinoi aeueo ?iaiia eii?aeeiaoei? aeey caaacia/aiiy aaeaeaaoieo ?aaeoeie i?aaiicio (Ieoeeaae/ I.N., 1974). Cacia/ai? iieiaeaiiy noaee iiioeithth/ith a?aoiaioaoei?th aeey aenia?eiaioaeueiiai aeineiaeaeaiiy aiaeiaaiiiai iiii?aeiiai iaioeaeo - IAIE. Aei oiai ae inioth/i eioa?aoo?ii aiaeiiinoi i?i aaaaoiieaiiainoue aieeao ii?i?ae?a ia ooieoei? aieueoinoi i?aaiia oa nenoai i?aaiicio ethaeeie i oaa?ei (Eiia?aaoeaaa E.A. e niaao., 1997; Eeoiaiia TH.A. e niaao., 1997; Cieiaa A.E., 1990; Ioaiieeiaa I.A., 1987) iaa?oioiaothoue aeioeieueiinoue aea/aiiy ?o ?aaoeyoi?iiai aieeao a iaeiie ic iaeaaaeeeaioeo nenoai iiaeo?eiee aiiainoaco - nenoaii aiaeii-aeaeo?ieioii? ??aiiaaae. Aenia?eiaioaeueii aeineiaeaeaiiy oeaieiii? eiioeaio?aoei? IAIE ye a aiiioaeaioni, oae i a aiiioici aeyaeee iaeiini?yiiaaiinoue ?? aieiaeo ciii (oaae.3). Iaeneiaeueii ?iaii iiii?aeo caoieniaaii o aeaio iieiaeoeo a?oiao oaa?ei, aea aiie aoee i?aeoe/ii iaeiaeiaeie (?>0,05). O
16-oeaeiaaeo uo?ia aeyaeaii ?o ai?iaiaeia cieaeaiiy (?<0,01). Oa?aeoa?ii, ui cia/aiiy aiiioaeaii/iiai IAIE cieceeeny a 2 ?ace, a aiiioica?iiai - a 4 ?ace. Aiaeii/an anoaiiaeaia ai?iaiaeia (?<0,01) ia?aaaaeaiiy aiiioaeaii/ii? eiioeaio?aoei? IAIE iaae aiiioica?iith o oaa?ei onio a?oi niinoa?aaeaiiy. Oaaeeoey 3 ?iaaiue eiioeaio?aoei? iao?ii?i-aieaoae?io a aiiioaeaioni,aiiioici oa ieacii e?iai o iioaeoieo oaa?ei a iioiaaiaci (I ± m) IAIEAie oaa?ei ?4 oeaeii, n=126 oeaeiia, n=1216 oeaeiia, n=12Aiiioaeaii/iee, ia/ia aieea Aiiioica?iee, ia/ia aieea Ieaciiaee, iiieue/e 4,90±0,19 0,87±0,06* 2,05±0,11 4,72±0,20 0,82±0,07* 2,11±0,10 2,31±0,10 0,22±0,04* 0,94±0,08p1>0,05

p2<0,01 p3<0,01 p1>0,05

p2<0,01 p3<0,01 p1>0,05

p2<0,01 p3<0,01 I?eiioee: * - ai?iaiaeiinoue ?icieoei iiae cia/aiiyie iieacieeia a aiiioaeaioni oa aiiioici (?<0,01); ?1 - ai?iaiaeiinoue ?icieoei iiae cia/aiiyie iieacieeia ia 4 i 6 oeaeiyo aeeooy; ?2 - ai?iaiaeiinoue ?icieoei iiae cia/aiiyie iieacieeia ia 4 i 16 oeaeiyo aeeooy; ?3 - ai?iaiaeiinoue ?icieoei iiae cia/aiiyie iieacieeia ia 6 i 16 oeaeiyo aeeooy. Noai aieiai? aeeiaiiee ieaciiai? eiioeaio?aoei? IAIE aoa aiaeiai/iei oiio, ui ?a?no?oaaany a oeaieii iiceo. O noaoaaic?ieeo oaa?ei cia/aiiy iieacieea aeyaeeeny a 2 ?ace ieae/eie, iiae o oaa?ei aieii 4 oa 6 oeaeiia. Iaaaaeaii ?acoeueoaoe aeineiaeaeaiiy IAIE a aiiioaeaioni, aiiioici oa ieacii e?iai naiae/aoue i?i cieaeaiiy aieaoaeiia?ai/ii? aeoeaiinoi a i?ioeani ?icaeoeo i noaiiaeaiiy ooieoeie. Aeey c’ynoaaiiy ni?yiiaaiinoi i nooiaiy aieeao IAIE a nenoaii aiaeii-aeaeo?ieioiiai iaiiio aoa i?iaaaeaiee ia?iee ei?aeyoeieiee aiaeic iiae eiai ieaciiaei ?iaiai oa aeayeeie iieacieeaie ooieoei? ie?ie (aeio?ac, iao?ieo?ac, o?eia?ia aene?aoeiy IAA2, A?I). Ianaiia?aae, i?eaa?oa? ia naaa oaaao iayaiinoue iiii?ieo iaaaoeaieo cia/aiue eiaoioei?ioa ei?aeyoei? aeey ae?o?aco e iao?ieo?aco o uo?ia 4- oa 6-oeaeiaaiai aieo. C oi/ee ci?o aea/aiiy iioaa?aoei? iaoaieciia iiii- oa aiethii?aaoeyoei? aeeeeea? iioa?an oaeiae inioaaiiy aeineoue aenieiai iaaaoeaiiai aca?iica’yceo iiae IAIE oa o?eia?iith aene?aoei?th IAA2. Oiio ia aeeeth/aia iiaeeeainoue o/anoi oeaio?aeueieo i ia?eoa?e/ieo iiii?aeia a iiaeoeyoe?? ?aaoeyoi?ii? aei? IA c ?nioaaiiyi iiae ieie cai?ioiueiai ca’yceo. Aeyaeaii a aenia?eiaioi i?ioeeaaeii ni?yiiaaii aieeae IAIE i IA ia aeine?aeaeai? iieacieee aene?aoi?ii? ie?eiai? ooieoei? ? iiaeoaa?aeaeaiiyi caaeainiaaiinoi aoaeo?a ?aaoeyoi?ieo iaoaiiciia, aiaeiiaiaeaeueieo ca caaacia/aiiy aiaeii-aeaeo?ieioiiai aiiainoaco. C ae?oaiai aieo, ?acoeueoaoe ei?aeyoeieiiai i ?aa?anieiiai aiaeicia, i?iaaaeaieo iiae ieaciiaei IAIE i A?I, naiae/aoue i?i ?o aca?iia iioaioeithaaiiy. I?e/iio nooiiiue oaeiai aieeao c aieii cieaeo?oueny. Iiaeoeyoeiy ooieoeiiiaeueii? aeoeaiinoi ?aiii-aia?ioaiceiiai? nenoaie i, ye ianeiaeie, ie?eiaiai e?iaioiea c aieo iiii?aeia, i/aaeaeii, ? iaeiei ic aaaeeeaeo oeyoia, /a?ac yeee ?aaeico?oueny ?o ?aaoeyoi?ia ?ieue a nenoaii aiaeii-aeaeo?ieioiiai aiiainoaco. Oinia eiiia?aoeiy aeineiaeaeaieo ai?iiiaeueieo oaeoi?ia iiaeoaa?aeaeo? i?eioeei ia?ae?eooy aai iiaeno?aoiaee, inioth/ee a aiieiai/ieo nenoaiao, caiaeii yeiio a ?aaoeyoei? iaeaieueo aaaeeeaeo ooieoeie aa?ooue niieueio o/anoue ??ciiiai?oi? iaoaiicie (Aeiaaa E.A.,1997). Oaeei /eiii, ?acoeueoaoe i?iaaaeaieo aenia?eiaioaeueieo aeineiaeaeaiue, aeiiiaithth/e inioth/i eioa?aoo?ii aiaeiiinoi, aeicaieythoue c?iaeoe aeniiaie i?i oa, ui noa?e ?aaoeyoi?iiai aieeao ?aiii-aiaiioaiceiiai? nenoaie, IA oa IAIE oinii i aaaaoi?aciai ia?aieioathoueny. Cieaeaiiy ooieoeiiiaeueii? aeoeaiinoi aea/aieo a?ieia?/ii aeoeaieo ?a/iaei, ui niinoa?iaaeiny a iioiaaiaci, naiae/eoue i?i noaaieicaoeith ?aaoeyoi?ieo i?ioeania. Oaea cieaeaiiy iiaea aooe coiiaeaia iioe?aiiyi niaeo?o oaeoi?ia, ye? iiaeo?eiothoue noaeinoue aioo?ioiueiai na?aaeiaeua i?aaiicio. Ioaea, noai ai?iiiaeueii? ?aaoeyoei? aiaeii-aeaeo?ie?oiiai aiiainoaco a o?c?ieia?/ieo oiiaao aecia/a?oueny noaaei?th ?icaeoeo, ia yeie aii noa? iaiaoiaeiei aeey iioeiaeueiiai ooieoeiiioaaiiy nenoaie a oeieiio. A E N I I A E E 1. Ai?iiiaeueiee noaoon caei?iai? iiaiia?iaeaeaii? aeeoeie oa?aeoa?eco?oueny aenieith aeoeaiinoth oa aeeiaii/iinoth iieacieeia ieaciiaeo ?AAN i IA. Ca?a?no?iaaii cia/aiiy A?I, EAI, IAA2 ? IAF2? iiaeooue neoaeeoe noaoenoe/ii ai?iaiaeieie e?eoa?iyie oiciieiai/iiai ia?aaiao ?aiiueiai iaiiaoaeueiiai ia?iiaeo. 2. O aeioae aeyaeaii ii?aeiaiiy aenieeo cia/aiue EAI oa ae?aaeaiiai aioeiao?ieo?e/iiai aoaeoo iiia?aeiei?oeei?aeo, ui ia? aaaeeeaa oiciieiai/ia cia/aiiy aeey iiaeo?eiee iiceoeaiiai iao?i?aiai aaeaino a oiiaao iai?oaeaiinoi aaeaioaoeieieo i?ioeania. 3. Ia?oee oeaeaeaiue iicaoo?iaiiai aeeooy aeeoeie oa?aeoa?eco?oueny iayaiinoth oiniiai aca?iica’yceo iiae A?I oa ieaciiaeie IAA2 i IAF2?, ui ? aaaeeeaei neeaaeiaei eiiiiiaioii o caaacia/aiii oiciieiai/iiai iioaioeiaeo aiaeii-aeaeo?ieioiiai aiiainoaco. 4. O iioaeoieo uo?ia o 16-oeaeiaaiio aioei aiaeaoaa?oueny nooo?aa cieaeaiiy aiinoo a ie?eiaie oeaieii IAA2, IAF2? oa A?I. Aiaeiai/ii oaiaeaioei? aieiai? aeeiaiiee aiaecia/aii oaeiae aeey IAIE a aiiioaeaioni, aiiioici oa ieacii e?iai. 5. Aeyaeaia o oaa?ei iieiaeoeo aieiaeo a?oi (4 oa 6 oeaeiia) aioeaeio?aoe/ia i aioeiao?ieo?e/ia ni?yiiaaiinoue oiciieiai/ii? aei? IAIE ni?ey? eiiiainaoei? i?ioeeaaeieo aoaeoia IA, iiaeo?eioth/e oei naiei iiceoeaiee aaeain aiaee i iao?ith a oiiaao ii?oiooieoeiiiaeueii? iac?ieinoi ie?ie. 6. Aea/aii a aenia?eiaioi eiiiiiaioe i?inoaaeaiaeeiiai?, ?aiii-aiaiioaiceiiai? oa aieaoaeiia?ai/ii? nenoai ia?aaoaathoue a oinieo iioaa?aoeieieo i noiiae?yaeieo aca?iiaiaeiineiao, niaoeeoi/iinoue i ooieoeiiiaeueia cia/ouinoue yeeo aecia/a?oueny noaaei?th iinoiaoaeueiiai ?icaeoeo. NIENIE ?IAIO, IIOAEIEIAAIEO CA OAIITH AeENA?OAOeI? 1. Aieioei A.I., Eiia?aaoeaaa E.A. Niaea?aeaiea yiaeiaaiiuo iieieaeia e aae?aiiei?oeeio?iiiiai ai?iiia a iicaiauo no?oeoo?ao o eioaeoiuo e?un ?acee/iiai aic?anoa // Iae?ioeceieiaey.- 1997.- O. 29.-N3.-N.163-166. 2. Aieioei A.I., Eiia?aaoeaaa E.A., Aacea?aaaeiue A.A., Na?aaeaiei A.A., Aa?iee A.A. Ieaciaiiue o?iaaiue eiiiiiaioia ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu o caei?iauo aeaoae a ?aiiai iaiiaoaeueiii ia?eiaea//Oe?aeineee aeioeie/aneee aeo?iae.-1998.- N4.-N.84-88. 3. Aieioei I.I. Ieaciiaa aeoeaiinoue ?aiii-aiaiioaicei-aeueaeinoa?iiiai? nenoaie i noai o?eia?ii? aene?aoei? iao?ith o caei?iaeo aeioae a ?aiiueiio iaiiaoaeueiiio ia?iiaei//Iaaee/ii ia?niaeoeae.- 1998.-N3.-N.65-67. 4. A?euaiei I.A., Cai/aiei A.I., Aieioei A.I. Ninoiyiea nenoaiu aiaeii-yeaeo?ieeoiiai aaeaina o ieaeiieoathueo a ?aiiai iinoiaoaeueiii iioiaaiaca // Ainiee iaoeiaeo aeineiaeaeaiue.-1998.-N5-6.- N.36-38. 5. Aieioei A.I. ?aiaeueiue aeineioac i?inoaaeaiaeeiia e iaeioi?ua o?eia?iua iieacaoaee o eioaeoiuo e?un a iioiaaiaca//Ainiee iaoeiaeo aeineiaeaeaiue.-1998.-N5-6.-N.39-40. 6. Aieioei A.I., Aacea?aaaeiue A.A.,Aaooeia O.A., ss?iuo I.A. Aeeiaieea ieaciaiiiai o?iaiy i?inoaiieaeia e aeoeaiinoe ?aieia o aeiiioaiiuo iiai?iaeaeaiiuo a ?aiiai iaiiaoaeueiii ia?eiaea// 75 eao iaaeeao?e/aneie neoaeau Eoaaineie iaeanoe: Na. iao/. o?.nio?. iaae. oi-oa e IAeEA.-Eoaaine,1996.-N.136-139. 7. Aieioei A.I. Eiioeaio?aoeey iaoeiiei-aieaoaeeia e aeoeaiinoue ?aieia a ieacia e?iae o eioaeoiuo e?un a aic?anoiii aniaeoa//Iaaeeei-aiieiai/ii i?iaeaie i?iieneiaiai ?aaiiio: Ca. iaoe. no. a/aieo EAeIO, 1997.-Aei.1.-N.25-27. Aiioaoeiy Aieioei I.I. Iniaeeaino? ai?iiiaeueii? ?aaoeyoe?? aiaeii-aeaeo?ieioiiai aiiainoaco ia ie?aieo aoaiao iinoiaoaeueiiai ?icaeoeo.-?oeiien. Aeena?oaoeiy ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe ca niaoeiaeueiinoth 14.03.03 - ii?iaeueia oiciieiaiy.-Oa?eianueeee aea?aeaaiee iaaee/iee oiiaa?neoao, Oa?eia,1999. Aeena?oaoeith i?enay/aii aea/aiith ieoaiue aca?iiaei? ai?iiiaeueieo iaoaiiciia aiaeii-aeaeo?ieioiiai aiiainoaco o caei?iaeo iiaiia?iaeaeaieo aeioae oa iioaeoieo aenia?eiaioaeueieo oaa?ei ?iciiai aieo. A ?acoeueoaoi eeiii/ieo aeineiaeaeaiue ?aiii-aiaiioaicei-aeueaeinoa?iiiai? nenoaie oa i?inoaaeaiaeeiia aecia/aii ia’?eoeaii e?eoa?i? iioeiaeueiiai ia?aaiao i?ioeania aaeaioaoei? o aeeoeie a ?aiiueiio iaiiaoaeueiiio ia?iiaei. Aenia?eiaioaeueii aeineiaeaeaiiy aeyaeee iiai iai?yiee ?aaeicaoei? oiciieiai/ieo aoaeoia iao?ii?i-aieaoae?io, yeee aenooia? a yeinoi iiaeoethth/i? i eii?aeeioth/i? eaiee a nenoaii iiii- oa aiethii?aaoeyoei?. I?iaeaiiino?iaaii, ui a iioiaaiaci aiaeaoaa?oueny nooo?aa cieaeaiiy ooieoeiiiaeueii? aeoeaiinoi aea/aieo ?aaoeyoi?ieo oaeoi?ia. Eeth/iai neiaa: iiaiia?iaeaeaii aeioe, aenia?eiaioaeueii oaa?eie, iioiaaiac, aiaeii-aeaeo?ieioiee aiiainoac, ai?iiie, ?aaoeyoeiy. Aiiioaoeey Aieioei A.I. Iniaaiiinoe ai?iiiaeueiie ?aaoeyoeee aiaeii-yeaeo?ieeoiiai aiiainoaca ia ioaeaeueiuo yoaiao iinoiaoaeueiiai ?acaeoey. - ?oeiienue. Aeenna?oaoeey ia nieneaiea iao/iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.03.03 - ii?iaeueiay oeceieiaey. - Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Aeenna?oaoeey iinayuaia eco/aieth aii?inia acaeiiaeaenoaey ai?iiiaeueiuo iaoaieciia aiaeii-yeaeo?ieeoiiai aiiainoaca o caei?iauo aeiiioaiiuo iiai?iaeaeaiiuo aeaoae e eioaeoiuo yenia?eiaioaeueiuo aeeaioiuo ?acee/iiai aic?anoa. A ?acoeueoaoa eeeie/aneeo eneaaeiaaiee ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu e i?inoaaeaiaeeiia ii?aaeaeaiu iauaeoeaiua e?eoa?ee iioeiaeueiiai oa/aiey i?ioeannia aaeaioaoeee o ?aaaiea a ?aiiai iaiiaoaeueiii ia?eiaea. Yenia?eiaioaeueiua enneaaeiaaiey auyaeee iiaia iai?aaeaiea ?aaeecaoeee oeceieiae/aneeo yooaeoia iaoeiiei-yieaoaeeia, eioi?ue aunooiaao a ea/anoaa iiaeoee?othuaai e eii?aeeie?othuaai caaia a nenoaia eiii- e aiethii?aaoeyoeee. I?iaeaiiino?e?iaaii, /oi a iioiaaiaca i?ienoiaeeo nouanoaaiiia nieaeaiea ooieoeeiiaeueiie aeoeaiinoe eco/aiiuo ?aaoeyoi?iuo oaeoi?ia. Eeth/aaua neiaa: iiai?iaeaeaiiua aeaoe, yenia?eiaioaeueiua aeeaioiua, iioiaaiac, aiaeii-yeaeo?ieeoiue aiiainoac, ai?iiiu, ?aaoeyoeey. Annotation Volochin A.N. Particularyties of the hormone regulation of the water-salt homeostase in the separate stages of the postnatal development.- Manuscript. The dissertation for receiving candidate of Medical sciences degree by speciality 14.03.03 - normal physiology. - State Medical University, Kharkov, 1999. The work is devoted to study of the questions of the interaction of the mechanisms of the water-salt homeostase by the healthy new-born full-term babys and by the intact experimental animals in the certain age. As the result of the clinical researches of the renin-angiotonin-aldosterone system and of the prostaglandins the objective criteria of the optimum course of adaptation processes by the baby in the early neonatal period were defined. The experimental researches have revealed the new direction of the realization of the phisiologic effects of the methionin-enkephalin, which appears as the modulation and coordination linc in the water-salt homeostase system. It was showed that in the ontogenesis the essential lowering of the functional activity of the studied regulatory factors took place. Key words: new-born children, experimental animals, ontogenesis, water-salt homeostase, hormones, regulation. I?aeienaii aei ae?oeo 25.12.98 ?. Oi?iao 60o90/16 Oi. ae?oe. a?e. 1,0. Oe?aae – 100 i?ei. Cai. ?45 Aeaeaaie/ee oeaio? EAeIO i. Eoaainuee, ea. 50-??//y iai?iie Eoaainueea, 1 ?aaeecaoeee oeceieiae/aneeo yooaeoia iaoeiiei-yieaoaeeia, eioi?ue aunooiaao a ea/anoaa iiaeoee?othuaai e eii?aeeie?othuaai caaia a nenoaia eiii- e aiethii?aaoeyoeee. I?iaeaiiino?e?iaaii, /oi a iioiaaiaca i?ienoiaeeo nouanoaaiiia nieaeaiea ooieoeeiiaeueiie aeoeaiinoe eco/aiiuo ?aaoeyoi?iuo oaeoi?ia. Eeth/aaua neiaa: iiai?iaeaeaiiua aeaoe, yenia?eiaioaeueiua aeeaioiua, iioiaaiac, aiaeii-yeaeo?ieeoiue aiiainoac, ai?iiiu, ?aaoeyoeey. Annotation Volochin A.N. Particularyties of the hormone regulation of the water-salt homeostase in the separate stages of the postnatal development.- Manuscript. The dissertation for receiving candidate of Medical sciences degree by speciality 14.03.03 - normal physiology. - State Medical University, Kharkov, 1999. The work is devoted to study of the questions of the interaction of the mechanisms of the water-salt homeostase by the healthy new-born full-term babys and by the intact experimental animals in the certain age. As the result of the clinical researches of the renin-angiotonin-aldosterone system and of the prostaglandins the objective criteria of the optimum course of adaptation processes by the baby in the early neonatal period were defined. The experimental researches have revealed the new direction of the realization of the phisiologic effects of the methionin-enkephalin, which appears as the modulation and coordination linc in the water-salt homeostase system. It was showed that in the ontogenesis the essential lowering of the functional activity of the studied regulatory factors took place. Key words: new-born children, experimental animals, ontogenesis, water-salt homeostase, hormones, regulation. I?aeienaii aei ae?oeo 25.12.98 ?. Oi?iao 60o90/16 Oi. ae?oe. a?e. 1,0. Oe?aae – 100 i?ei. Cai. ?45 Aeaeaaie/ee oeaio? EAeIO i. Eoaainuee, ea. 50-??//y iai?iie Eoaainueea, 1

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