Оптимізація активних методів лікування ендогенної інтоксикації у хворих при критичних станах: Автореф. дис… канд. мед. наук / Т.В. Джоджуа, Дніпропе

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AeI?I?IIAO?IANUeEA AeA?AEAAIA IAAeE*IA AEAAeAI?ss

AeAEIAeAEOA

OAOssIA AAEAIOEI?AIA

OAeE: 616-036.65: 615.246.2

IIOEI?CAOe?ss AEOEAIEO IAOIAe?A E?EOAAIIss AIAeIAAIII? ?IOIENEEAOe?? O
OAI?EO I?E E?EOE*IEO NOAIAO

14.01.30 — aianoac?ieia?y oa ?ioaineaia oa?ai?y

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa iaaee/ieo iaoe

Aei?i?iiao?ianuee — 1998

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Aeiiaoeueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao?

?i. I. Ai?ueeiai, I?i?noa?noai ioi?iie caei?iay Oe?a?ie.

Iaoeiaee ea??aiee: aeieoi? iaaee/ieo iaoe, i?ioani? Oaii
Aaeaioeia Iao??aia, i?ioani? eaoaae?e aianoac?ieia??, ?ioaineaii?
oa?ai?? oa iaaeeoeeie iaa?aeeeaaeieo noai?a oaeoeueoaoo i?neyaeeieiiii?
ina?oe Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I.
Ai?ueeiai

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?
Ee?aoiaiei Ieaia Ieeiea?aia, caa?aeoaa/ eaoaae?e aianoac?ieia?? oa
?aai?iaoieia?? c eo?nii AAI oaeoeueoaoo i?neyaeeieiiii? ina?oe
Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeai??

aeieoi? iaaee/ieo iaoe, i?ioani? Eo?aiia ?aaai Iao?iae/, caa?aeoaa/
eaoaae?e aianoac?ieia?? oa ?ioaineaii? oa?ai?? Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I. Ai?ueeiai

I?ia?aeia onoaiiaa: Oa?e?anueeee aea?aeaaiee iaaee/iee
oi?aa?neoao, eaoaae?a iaaeeoeeie iaa?aeeeaaeieo noai?a oa
aianoac?ieia??, IIC Oe?a?ie, i.Oa?e?a.

Caoeno a?aeaoaeaoueny » 22 » n?/iy 1999 ?. i 13-00 aiae. ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 08. 601. 01 o Aei?i?iiao?ianuee?e
aea?aeaai?e iaaee/i?e aeaaeai??, ca aae?anith: 320044,
i.Aei?i?iiao?ianuee, aoe. Aeca?aeeinueeiai, 9.

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Aei?i?iiao?ianueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ca aae?anith:

i. Aei?i?iiao?ianuee, aoe. Aeca?aeeinueeiai, 9.

Aaoi?aoa?ao ?ic?neaiee » 19 » a?oaeiy 1998 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii?

?aaee, aeioeaio
Oea/aiei A. I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue i?iaeaie. Oaeineiiaeaiiy iaoiae?a e?eoaaiiy oai?eo a
e?eoe/iiio noai? (EN) ? aeooaeueiith i?iaeaiith no/anii? ?ioaineaii?
oa?ai??. Oea iiynith?oueny aenieith eaoaeuei?noth, o?eaaeei e?eoaaiiyi,
aaeeeei a?aenioeii oneeaaeiaiue ia oii? ?icaeoeo neiae?iio iie?i?aaiieo
ii?ooaiue. (?yaia A.A., 1994; Gosbell I.B., 1995; Onaiei E.A., 1996;
Aeiieoeeee E.E, 1997;).

Oi?ioaaiiy oa ?icaeoie iaaeeoeeie e?eoe/ieo noai?a coiiaeei nooiaiaaa
aeine?aeaeaiiy neiae?iio iie?i?aaiieo ii?ooaiue, (Marshall I.C., 1993;
Ceeueaa? A.I., 1995; Pastores S.M., 1996; Reemst P.H., 1996; Eiiu/aa
A.A., 1988) eiee a ia?oo /a?ao, aea/aeenue ii?ooaiiy ooieoe?? aeeoaiiy
oa e?iaiia?ao. I?ioa aeyaeeinue, ui anoaiiaeaiiy oeeo ooieoe?e ia
caaacia/eei aenieiai aoaeoo e?ea?aeaoe?? e?eoe/iiai noaio ?c-ca
iaiai?ioieo ci?i ie?ie, ia/?iee, naeac?iee, oeoieiai-eeoeiaiai o?aeoo.
I?e oeueiio aoei anoaiiaeaii, ui aiaeiaaiia ?ioieneeaoe?y ?
iaiacyceiaith neeaaeiaith /anoeiith e?eoe/iiai noaio ? iio?aao? naiai
aeoeaiiai e?eoaaiiy, oae ye oea iiia?aaeaeo? ?icaeoie iaiai?ioiino? i?ae
/an e?eoe/iiai noaio. (Lipman J., 1991; Oaii A.I., 1992; Mammen
E.F.,1993; Eo?aiia A.I., 1996, Mendger M. D., 1996).

?ieue ? i?noea aiaeiaaiii? ?ioieneeaoe?? i?ae /an e?eoe/iiai noaio
??cii? ao?ieia?? aecia/eei no/ania oyaeaiiy i?i iaoiaaiac e?eoe/iiai
noaio c iiceoe?e neiae?iio nenoaiii? caiaeueii? a?aeiia?ae? — NNCA (Aioi
?., 1995; Bone R. C., 1995; Chalasani N., 1996).

Oeae neiae?ii ia?aaeaa/a? oi?ioaaiiy e?eoe/iiai noaio ye ?acoeueoao ae??
eaneaaeo iaae?aoi??a oa iaoaaie?o?a i?ae /an ??ciiiai?oieo
aeno?aiaeueieo aieea?a. Oae, a iniia? oi?ioaaiiy nenoaiii? caiaeueii?
a?aeiia?ae? o ?ac? naineno eaaeeoue ?ioaeoe?eiee eiiiiiaio (Bone R.C.,
1994, Aaeueoaiae A.?., 1998), o ?ac? oieneei-aea?a?/iiai aea?iaoeoo
ioneiaei iaoai?ciii NNCA ?, a iniiaiiio, oeeoioiene/i? aea?a?/i?
?aaeoe?? (II oei aea?a??) (Eaaa? E, 1990; ?ieo A, 1991), o ?ac?
neiae?iio o?eaaeiai noeniaiiy e?eoe/iee noai oi?io?oueny o a?aeiia?aeue
ia ?oai?/ii-?aia?ooc?ei? iaoai?cie aea?eueiaiiy oeeoie?i?a (Aeeaiei
I.A., 1990).

Oi/a a no/ani?e aoa?aioi?e iaaeeoeei? ?nio? aeae?eueea aeanyoe?a
iaoiae?a onoiaiiy aiaeiaaiii? ?ioieneeaoe??, ye? aeicaieythoue
iiaeaethaaoe oieneei-e?iaoe/iee i?ioean (Aaaea?ieeiaa E.A., 1992;
Aieiai?neee A. A., 1997; Ooae/ I.A.,1997; Cayaei A. A., 1998), aaaaoi
ieoaiue e?ea?aeoaaiiy aiaeiaaiii? ?ioieneeaoe?? i?ae /an e?eoe/iiai
noaio caeeoathoueny ia aei e?ioey ?icacycaieie (Iie?ianeee A.E.,1997;
Ao?aae/ I.A., 1997; ?oaeiia A. A., 1998).

Oiio iioei?caoe?y aeoeaieo iaoiae?a e?eoaaiiy aiaeiaaiii? ?ioieneeaoe??
o oai?eo i?ae /an e?eoe/ieo noai?a c iaoith iiia?aaeaeaiiy iaiai?ioiino?
? iie?auaiiy ?acoeueoao?a e?eoaaiiy ? iaaeoi aeooaeueiith i?iaeaiith.

Cacycie ?iaioe c iaoeiaeie i?ia?aiaie, oaiaie. Aeena?oaoe?eia ?iaioa
“Iioei?caoe?y aeoeaieo iaoiae?a e?eoaaiiy aiaeiaaiii? ?ioieneeaoe?? o
oai?eo i?e e?eoe/ieo noaiao” ? o?aaiaioii ieaiiai? noi?nii? ?iaioe
eaoaae?e aianoac?ieia??, ?ioaineaii? oa?ai?? oa iaaeeoeeie
iaa?aeeeaaeieo noai?a oaeoeueoaoo i?neyaeeieiiii? ina?oe Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I. Ai?ueeiai, I?i?noa?noaa
ioi?iie caei?iacy Oe?a?ie, eaai?aoi??? ?ioiieia?? ?inoeoooo o?ieia?? oa
iao?ieia?? AII Oe?a?ie “?ic?iaea iaoiae?a eiiieaenii? ae?aaiinoeee oa
?ioaineaii? oa?ai?? neiae?iio aiaeiaaiii? ?ioieneeaoe?? oa
?ioiiaeao?oeeoo o oai?eo a e?eoe/ieo noaiao” (? aea?ae?a?no?aoe??
0197U002122).

Iaoa ? caaea/? aeine?aeaeaiiy. Iaoa ?iaioe iieyaa? o iie?auaii?
?acoeueoao?a eiiieaeniiai e?eoaaiiy (cieaeaiiy eaoaeueiino?, nei?i/aiiy
ia??iaeo aiaeioieneeico) oai?eo o e?eoe/ieo noaiao, o ?ac? naineno,
oieneei-aea?a?/iiai aea?iaoeoo oa neiae?iio o?eaaeiai noeniaiiy oeyoii
aeei?enoaiiy iioei?ciaaieo aeoeaieo iaoiae?a e?eoaaiiy aiaeiaaiii?
?ioieneeaoe??.

Aeey aeinyaiaiiy iaoe aoee iinoaaeai? oae? caaea/?:

1.Aea/eoe ee?i?/i?, a?io?i?/i? oa ?ioiieia?/i? iieacieee o oai?eo a
e?eoe/iiio noai? o ?ac? naineno, oieneei-aea?a?/iiai aea?iaoeoo,
neiae?iio o?eaaeiai noeniaiiy.

2.Anoaiiaeoe iayai?noue aiaeiaaiii? ?ioieneeaoe??, ye neeaaeiai? /anoeie
iie?i?aaiieo ii?ooaiue, oa ?? oa?aeoa?i? iniaeeaino? oeyoii ioe?iee
ee?i?/ieo, a?io?i?/ieo oa ?ioiieia?/ieo iieaciee?a o oai?eo a e?eoe/iiio
noai? o ?ac? naineno, oieneei-aea?a?/iiai aea?iaoeoo, neiae?iio
o?eaaeiai noeniaiiy.

3.Noi?ioethaaoe e?eoa??? neiae?iio nenoaiii? caiaeueii? a?aeiia?ae? i?ae
/an e?eoe/iiai noaio, coiiaeaiiai nainenii, oieneei-aea?a?/iei
aea?iaoeoii, neiae?iiii o?eaaeiai noeniaiiy.

4.Iioei?coaaoe aeoeai? iaoiaee e?eoaaiiy aiaeiaaiii? ?ioieneeaoe?? o
oai?eo i?ae /an e?eoe/ieo noai?a ??cii? ao?ieia??.

5.Aeine?aeeoe aieea iioei?ciaaieo aeoeaieo iaoiae?a e?eoaaiiy
aiaeiaaiii? ?ioieneeaoe?? ia ia?aa?a e?eoe/iiai noaio o ?ac? naineno,
oieneei-aea?a?/iiai aea?iaoeoo, neiae?iio o?eaaeiai noeniaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa anoaiiaeaii, ui:

oa?aeoa? oa iniaeeaino? ci?i iieaciee?a iaoaaie?cio oa ?ioi?oaoo
caeaaeaoue a?ae ao?ieia?? EN ? iathoue nai? iniaeeaino? o ?ac? naineno,
oieneei-aea?a?/iiai aea?iaoeoo, neiae?iio o?eaaeiai noeniaiiy;

e?eoe/iee noai o oai?eo ia nainen, oieneei-aea?a?/iee aea?iaoeo,
neiae?ii o?eaaeiai noeniaiiy oa?aeoa?eco?oueny neiioiiieiiieaenii
neiae?iio nenoaiii? caiaeueii? a?aeiia?ae? (NNCA);

i?aeoaa?aeaeaia ?ieue oaeoi?a iae?ico iooeeie (OII) aeueoa, ye iaeiiai c
aieiaieo iaae?aoi??a, ui a?aeiia?aeathoue ca ?i?oe?aoe?th ?icaeoeo
neiae?iio nenoaiii? caiaeueii? a?aeiia?ae?. ??aaiue oeueiai oeeoie?ia a
e?ia? a?aeia?aaeo? oace ?icaeoeo NNCA. Ia?a?nii aenie?, o ii??aiyii? c
eiio?ieai, iieacieee OII aeueoa na?ae/aoue i?i iaeiio?ieueiaaio
oeeoie?iiao aeoeaaoe?th, c?ea i?e?iaei?o iaoai?ci?a ?aaoethaaiiy
i?iaeoeoe?? oeeoie?i?a. I?ioa, ia?a?nii iecuee? iieacieee OII aeueoa, o
ii??aiyii? c eiio?ieai, a?aeia?aaeothoue iayai?noue ?ioiiia?ae?/o ? ?
i?iaiinoe/ii iani?eyoeeaith iciaeith o caaa?oaii? e?eoe/iiai noaio;

noi?ioeueiaai? iniiai? ee?i?/i? oa eaai?aoi?i? e?eoa??? NNCA i?ae /an
e?eoe/ieo noai?a ??cii? ao?ieia??;

canoinoaaiiy o eiiieaeniiio e?eoaaii? i?ae /an EN ??cii? ao?ieia??
iioei?ciaaieo aeoeaieo iaoiae?a caaacia/o? iaoiaaiaoe/ia e?eoaaiiy
oai?eo;

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aecia/a?oueny aenieith
aoaeoeai?noth i?iiiiiaaiiai eiiieaeniiai e?eoaaiiy oai?eo o e?eoe/ieo
noaiao ??cii? ao?ieia??, oae ye caaacia/o? ciaioaiiy eaoaeueiino? o ?ac?
naineno c 32, 4 aei 8 %, o ?ac? oieneei-aea?a?/iiai aea?iaoeoo c 10, 7
aei 4 %, o ?ac? neiae?iio o?eaaeiai noeniaiiy c 37,4 aei 22,2 %;
nei?i/aiiy ia??iaeo aiaeioieneeico, a?aeiia?aeii, c 24 aei 12 ae?a, c 21
aei 12 ae?a ? c 10 aei 14 ae?a, ui ii?aeio?oueny ?c cieaeaiiyi
iaoa??aeueieo aeo?ao.

?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeaii o ?iaioo
a?aeae?eaiiy caaaeueii? ?aai?iaoe?? iaeanii? ee?i?/ii? e?ea?i? ?i. I. ?.
Eae?i?ia i. Aeiiaoeueea (aeo oi?iaaaeaeaiiy ? 04/148 a?ae 03.12.98 ?.),
a?aeae?eaiiy aianoac?ieia?? oa ?ioaineaii? oa?ai?? cae?cie/ii? ee?i?/ii?
e?ea?i? ia no. Aeiiaoeuee (aeo oi?iaaaeaeaiiy ? 01/68 a?ae 21.10.98 ?.),
a?aeae?eaiiy ?ioaineaii? oa?ai?? i?nueei? e?ea?i? ? 4 i. Aeiiaoeueea
(aeo oi?iaaaeaeaiiy ? 02/106 26.11.98 ?.), a?aeae?eaiiy aianoac?ieia??
oa ?ioaineaii? oa?ai?? cae?cie/ii? e?ea?i? i. ssneioaaoi? (aeo
oi?iaaaeaeaiiy ? 1129 a?ae 26.11.98 ?.), iaoa??aee aeena?oaoe??
aeei?enoiaothoueny o iaa/aeueiiio i?ioean? e?ea??a — ?ioa?i?a oa e?ea??a
— eo?naio?a — aianoac?ieia?a Aeiiaoeueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo.

Iniaenoee aianie caeiaoaa/a. Noi?nii ?c ni?a?ia?oieeaie ?aai?iaoe?eiiai
a?aeae?eaiiy oa a?aeae?eaiiy aoa?aioieo iaoiae?a aaoi?ii aoee aea/ai? ?
i?iaiae?ciaai? ee?i?/i?, a?io?i?/i? oa ?ioiieia?/i? iieacieee o 157
oai?eo a EN ? o 20 i?aeoe/ii caei?iaeo aeiii??a. ?aeay ?ic?iaee
ee?i?/ii? oa?aeoa?enoeee neiae?iio nenoaiii? caiaeueii? a?aeiia?ae?
iaeaaeeoue iaoeiaiio ea??aieeo ae.i.i., i?io. A. I. Oaii. Caeiaoaa/ai
iniaenoi aeeiioaaeenue: iaeyae oai?iai, ca?? aiaiiaco, i?ecia/aiiy
iaiao?aeiiai ianoaaeaiiy ? e?eoaaiiy. Caienoaaeanue AEA, OeAAe,
eaithethaaeenue iaa?no?aeuei? oa ia?eoa?e/i? noaeeie, anoaiiaethaaany
a?oa??i-aaiiciee (A-A) ooio ca Ne?eaia?ii, i?iaiaeeany A-A aaiiae?ae?c,
aaiiea?aiia?ooc?y, ieaciaoa?ac, aooioeueo?ao?ieaoiaa ii?ii?iaiy e?ia?
(AOOIE), “caa??” enaiinaeac?iee ? i?aeaioiaea ?? aei ?iaioe,
aaiinieaiiia?ooc?y, ieacianieaiiia?ooc?y. ?acii c iaoieiaiaiaoiiaie
aeeiiai? a?noieia?/i? aeine?aeaeaiiy

icyc?a oa i?aeoe??ii — aee?iai? ee?oeiaeie iiia?eeo oai?eo ia neiae?ii
o?eaaeiai noeniaiiy (NON), ii?oieia?/ia aea/aiiy enaiinaeac?iee aei ?
i?ney ia?ooc??.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? iaaiai?ai?
ia I eiia?an? aianoac?ieia?a-?aai?iaoieia?a Oe?a?ie “Aeooaeuei? i?iaeaie
aianoac?ieia?? oa ?aai?iaoieia??” o i?no? Caii??aeae?, 1992 ??e; Ieaioi?
anioe?aoe?? aianoac?ieia?a “O?aaia. Aianoac?y oa ?ioaineaia oa?ai?y” o
i?no? Eooeueeo, 1994 ?.; O ?a?iiaenueeiio eiia?an? aianoac?ieia?a,
N?aeiae, Aano?ae?y, 1996 ?.; VII cc?cae? aianoac?ieia?a Oe?a?ie, Oa?e?a,
1996 ?.; VI Ana?in?enueeiio cc?cae? aianoac?ieia?a oa ?aai?iaoieia?a,
Iineaa, aeiaoaiue, 1998 ?.; ia can?aeaiiyo iaeaniiai iaoeiaiai
oiaa?enoaa aianoac?ieia?a oa ?aai?iaoieia?a (Aeiiaoeuee, 1992, 1993,
1994, 1996 1997, 1998 ?.?.).

Aeena?oaoe?y i?ieoea ai?iaaoe?th ia ?icoe?aiiio can?aeaii?
ni?a?ia?oiee?a eaoaae?e aianoac?ieia?? oa ?ioaineaii? oa?ai??;
aianoac?ieia??, ?ioaineaii? oa?ai?? oa iaaeeoeeie iaa?aeeeaaeieo noai?a
oaeoeueoaoo i?neyaeeieiiii? ina?oe; aini?oaeueii? o??o?a?? ?1;
aioo??oi?o oai?ia ? 1 c eo?nii ee?i?/ii? ?ioiieia?? Aeiiaoeueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo ?i. I. Ai?ueeiai (31.08.98.).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 10 ae?oeiaaieo i?aoeue,
?c ieo-4 noaoo? o ?aoeaiciaaieo iaoeiaeo aeo?iaeao, 6 a ca??ieeao oac?a
? eiioa?aioe?e, iaea?aeaii iaoaio ia aeiao?ae.

Ianya oa no?oeoo?a aeena?oaoe??.

Aeena?oaoe?y aeeeaaeaia ia 148 noi??ieao iaoeiiieniiai oaenoo, i?noeoue
33 oaaeeoe?, 11 ?enoie?a, ye? caeiathoue 56 noi??iie. Neeaaea?oueny ?c 5
?icae?e?a: iaeyaeo e?oa?aoo?e, /ioe?ueio ?icae?e?a aeanieo
aeine?aeaeaiue, ocaaaeueiaiiy aiae?co oa ?acoeueoao?a aeine?aeaeaiiy, a
oaeiae aeniiae?a. Iieaae/ee e?oa?aoo?e aeeth/a? 222 aeaea?aea
?ioi?iaoe??, ?c ieo 134 — a?o/eciyieo ? 88 — ca?oa?aeieo aaoi??a.

INIIAIA *ANOEIA

Iaoa??ae ? iaoiaee aeine?aeaeaiiy. Aea/aiee ? i?iaiae?ciaaiee ia?aa?a
e?eoe/iiai noaio o 157 oai?eo a?eii a?ae 18 aei 67 ?ie?a, c ieo
/ieia?e?a — 80, ae?iie — 77.

Ioe?iea noaio oai?eo i?iaiaeeeanue a?aeiia?aeii aei ao?ieia?? e?eoe/iiai
noaio: 62 oai?eo ia nainen; 54 oai?eo ia oieneei — aea?a?/iee aea?iaoeo
(OAAe); 41 oai?ee ia neiae?ii o?eaaeiai noeniaiiy (NON).

Oai?? eiaeii? iicieia?/ii? oi?ie EN oiiaii aoee ?icae?eai? ia aea?
a?oie, caeaaeii a?ae niiniao e?eoaaiiy. Ia?oo a?oio neeaee 97 iaoe??io?a
(37 ia nainen, 28 ia OAAe, 32 ia NON), yeei aeeiioaaeanue eiiieaenia
caaaeueiii?eeiyoa ?ioaineaia oa?ai?y a?aeiia?aeii aei ao?ieia??
caoai?thaaiiy ? oa?aeoa?o i?iyao e?eoe/iiai noaio. Ae?oao a?oio neeaee
60 iaoe??io?a (25 ia nainen, 26 ia OAAe, 9 ia NON), o eiiieaen
?ioaineaii? oa?ai?? yeeo aoee aeeth/ai? iioei?ciaai? aeoeai? iaoiaee
e?eoaaiiy aiaeiaaiii? ?ioieneeaoe??.

Aecia/aee noai aaiiaeeiai?ee ca a?oa??aeueiei oeneii, /anoioith
na?oeaaeo nei?i/aiue, aeaeo?iea?ae?ia?ao??th (AEA), aoiea?ae?ia?ao??th
(AoiEA), ?ioaa?aeueiith ?aia?ao??th o?ea (ca I. ?. Oeuaieii) c
ae?aooaaiiyi oaea?iiai ianyao (OI), oaeeeiiiai ianyao na?oey (OIN),
na?oeaaiai oa oaea?iiai ?iaeaen?a (N? e O?), caaaeueiiai ia?eoa?e/iiai
noaeeiiiai iii?o (CINI).

Noai aeeoaeueii? nenoaie aecia/aee ca /anoioith aeeoaiiy oa
aoneoeueoaoeaiith ea?oeiith, aeaieie ?aioaaiieia?/iiai aeine?aeaeaiiy oa
eiiicthoa?ii? oiiia?ao?? i?aai?a a?oaeii? ee?oee.

Ae?aaiinoeea aiaeiaaiii? ?ioieneeaoe?? cae?enithaaeanue ia i?aenoaa?
aea/aiiy 59 a?io?i?/ieo oa ?ioiieia?/ieo iieaciee?a ia /an iinooiaiiy oa
i?ney aeoiaeo ?c EN o ii??aiyii? c iieacieeaie eiio?ieueii? a?oie — 20
caei?iaeo in?a a a?oe? a?ae 18 aei 67 ?ie?a.

O iiia?eeo oai?eo i?iaaaeai? a?noi-ii?oieia?/i? aeine?aeaeaiiy na?oey,
eaaaiue, ia/?iee, ie?ie, aieiaiiai iiceo, naeac?iee, oe??e, icyc?a,
i?aeoe??ii-aee?iai? ee?oeiaeie.

Iaea?aeai? aeai? ia?iaeai? noaoenoe/ii ia IBM PC AT 486 o iaeao? i?ia?ai
STADIA, STATGRAF, LOTUS, MICROSOFT EXEL. Aeei?enoaiee iaoiae
aa??aoe?eii? noaoenoeee ii??aiyiiy na?aaei?o ca t- e?eoa???i
Nouethaeaioa, F-e??oa???i O?oa?a oa ei?aeyoe?eiiai aiae?co (Eaeei A. O.,
1990).

Aeeiiaii 85 ieaciaoa?ac?a, 164 aaiiae?ae?ca, 6 e?ioiae?ae?c?a, 28
aaiiea?aiia?ooc?e, 72 oeueo?ao?ieaoiaeo ii?ii?iaiue e?ia?, 95
aaiinieaiiia?ooc?e, 41 ieacianieaiiia?ooc?y, on?i oai?ei i?iaiaeeeanue
aano?iaioa?ini?aoe?y.

?acoeueoaoe aeanieo aeine?aeaeaiue. Noai on?o ianoaaeaieo oai?eo
?icoe?ithaaee ye e?eoe/iee, oae ye o?aaeaiiy 5 i?aai?a niinoa??aaee o 39
(62 %) oai?eo ia nainen, 8 (16%) — ia oieneei — aea?a?/iee aea?iaoeo, 27
(66%) — ia neiae?ii o?eaaeiai noeniaiiy. O?aaeaiiy 3 i?aai?a aeyaeaii o
23 (38 %) oai?eo ia nainen, 25 (46%) — ia oieneei — aea?a?/iee
aea?iaoeo, 14 (34%) — ia neiae?ii o?eaaeiai noeniaiiy.

Ii?ooaiiy e?iaiia?ao a?aecia/ai? o an?o oai?eo, oi/a iaoai?cie
oi?ioaaiiy aoee ??cieie ? a?aeia?aaeoaaee i?eai?/aiiy nei?i/oaaeueii?
caeaoiino? i?iea?aea, iioeiaeaeaiiy ooieoe?? e?aiai oeoii/ea c ?icaeoeii
a?iioaic??, aae aei eieaina, i?ae aieeaii ea?ae?iaeai?ani?ii?
noanoaioe?? aiaeioienei?a.

Iaei??th ?c i?e/ei aaiiaeeiai?/ieo ii?ooaiue o oai?eo ia nainen aoa
naioe/iee aiaeiea?ae?o, anoaiiaeaiee ca aeiiiiiaith AoiEA o 21 (34%)
iaoe??ioa.

O oai?eo ia NON ii?ooaiiy e?iaiia?ao ia?aaaaeii aoee iiacycai? c
a?ia?a?ae?aoaoe??th ? aeaeo?ie?oieie ?iceaaeaie.

Ae?oaei ca cia/ei?noth i?iyaii neiae?iio iie?i?aaiieo ii?ooaiue aaaaeaee
aeeoaeueio iaaeinoaoi?noue (AeI).

Iniiaiith i?e/eiith AeI o oai?eo ia nainen aoea aeano?oeoeaia iiaaiii?y.
I?ae /an oieneei — aea?a?/iiai aea?iaoeoo ii?ooaiiy aeeoaiiy aoee
ia?aaaaeii coiiaeai? noi?iaiaeaeoth/ei a?iio?oii oa ?ani??aoi?iei
aeenno?an neiae?iiii aei?ineeo. I?ae /an neiae?iio o?eaaeiai noeniaiiy
aeeoaeueia iaaeinoaoi?noue ??ciiai nooiaiy aoea ia?aaaaeii coiiaeaia
a?ia?a?ae?aoaoe??th.

Ioaea, iacaaaeath/e ia oa, ui aaiiaeeiai?/i? ii?ooaiiy oa aeeoaeueia
iaaeinoaoi?noue aoee a?aecia/ai? o an?o oai?eo ia /an iinooiaiiy, ?o
oa?aeoa? oa nooi?iue oyaeeino? aoee ??cieie a?aeiia?aeii aei ao?ieia??
EN.

Ii?yae c oeei, aaaeeeaei ee?i?/iei i?iyaii e?eoe/iiai noaio o aea/aieo
oai?eo aoa a?ia?oa?i?/iee neiae?ii.

Aaeoa???i?y aoea anoaiiaeaia o 58% oai?eo ia nainen, o 44% oai?eo ia
OAAe ? o 49% oai?eo ia NON ? a?aeia?aaeoaaea iayai?noue ?ioaeoe?eiiai
oaeoi?a o ?ac? naineno, a oaeiae o?aineieaoe?th ?ioaeoe?? i?ae /an
iioeiaeaeaiiy oe??e oa neeciaeo i?e NON oa OAAe.

O an?o oai?eo ia OAAe o?aaeaiiy oe??e aaaaeaee aieiaiei ee?i?/iei
i?iyaii oai?iae. Oa?aeoa?iith aoea iayai?noue a?eo?iaea?i??,
oieneeiaea?i??, iaoe?iiai a?aeoa?oaaiiy ai?aea?i?na c ooai?aiiyi
a?iceaii? iiaa?oi?, aaeeeeo iooe??a, iiceoeaiee neiioii I?eieuenueeiai,
aie?ni?noue an??? oe??e.

Ii?yae c anoaiiaeaieie ii?ooaiiyie e?iaiia?ao oa aeeoaiiy ia /an
iinooiaiiy aoee aeyaeai? ci?ie a?io?i?/ieo oa ?ioiieia?/ieo iieaciee?a o
oai?eo ia nainen (Oaae.1), ia OAAe (Oaae.2.), ia NON (Oaae.3.). I?ae /an
aiae?co iaea?aeaieo aeaieo aeae?eai? o?e a?oie aca?iiiiacycaieo ci?i.

Oaaeeoey 1

Aeeiai?ea aeayeeo iieaciee?a e?ia? (Im) o oai?eo ia nainen, ye? aeaeeee,
a ii??aiyii? c eiio?ieai (? < 0,05) IieacieeeEiio?ieueAei e?eoaaiiyI?ney e?eoaaiiy(n=20)1 oa 2 a?.(n=62)1 a?.(n=37)2 a?.(n=25)Eaeeioeeoe, o 109/e6,38±0,1015,90±2,2012,41±0,578,00±1,11E?ioioeeoe, %26,50±0,2615,50±1,6416,80±1,9422,30±1,66CD 4 / CD 82,55±0,011,39±0,102,24±0,112,63±0,20?E-2-?+ , %10,50±0,815,40±0,376,58±0,188,03±1,15OII, aeueoa, iea/ia60,6±12,4660,4±11,2440,09,1180,111,0O?iiaioeeoe, o 109/e253.0±3,3146,0±9,2168,011,6220,0±5,8E??1,01±0,015,02±0,993,29±0,321 ,84±0,23NII, iae.iio.u?euei.0,22±0,030,54±0,010,37±0,010,28±0,01 I?ei?oee: n - e?euee?noue ianoaaeaieo Oaaeeoey 2 Aeeiai?ea aeayeeo iieaciee?a e?ia? (Im) o oai?eo ia OAAe, ye? aeaeeee, a ii??aiyii? c eiio?ieai (? < 0,05) IieacieeeEiio?ieueAei e?eoaaiiyI?ney e?eoaaiiy(n=20)1 oa 2 a?.(n=54)1a?.(n=28)2a?.(n=26)E?ioioeeoe, %26,50±0,2613,60±1,5315,70±1,9320,28±1,60Iaee/eiyae.iaeo?.,%3,10±0,2520, 20±3,1917,67±0,748,67±0,73CD 4 / CD 82,55±0,011,37±0,071,66±0,192,60±0,19?E-2-?+ , %10,50±0,814,95±0,416,12±0,588,16±0,09OII, iea / ia60,6±12,4450,2±16,7260,610,1218,28,6O?iiaioeeoe, o 109/e253,0±3,3152,0±6,7196,0±4,9240,0±5,80E??1,01±0,017,10±0,786,86±0,52 2,39±0,03NII, iae.iio.u?euei.0,22±0,030,33±0,020,29±0,010,23±0,01 I?ei?oee: n - e?euee?noue ianoaaeaieo Oaaeeoey 3 Aeeiai?ea aeayeeo iieaciee?a e?ia? (Im) o oai?eo ia NON, ye? aeaeeee, a ii??aiyii? c eiio?ieai (p < 0,05) IieacieeeEiio?ieueAei e?eoaaiiyI?ney e?eoaaiiy(n=20)1 oa 2 a?.(n=41)1 a?.(n=32)2 a?.(n=9)E?ioioeeoe, %26,50±0,2615,90±1,0514,80±1,4419,15±2,13CD 4 / CD 82,55±0,012,97±0,504,08±0,432,97±0,79?E-2-?+ , %10,50±0,813,03±0,144,08±0,436,40±0,15O?a?eiiaai, a/e2,750,236,910,364,860,352,750,21E??1,01±0,017,63±0,664,36±0,923,53±0, 46NII,iae.iio.u?euei.0,22±0,030,77±0,060,62±0,090,43±0,04ANO,iiieue/e /0,33±0,012,85±0,411,54±0,290,67±0,07E?aaoei?i,iiieue/e0,080±0,0010,702± 0,0500,501±0,0400,455±0,032 I?ei?oee: n - e?euee?noue ianoaaeaieo Ia?oa a?oia ioa?aeoa?eciaaia ye aeac?ioaa?aoe?y oaaioeeoa?ii- e?ioioeeoa?iiai eiiieaeno. Oea i?iyaeyeinue eaeeioeeoicii, iaee/eiyaea?iei c?ooaiiyi ? e?ioiiai??th, oa?aeoa?ieie aeey on?o a?oi oai?eo. CD - 3 - ee?oeiia aeenooieoe?y noi?iaiaeaeoaaeanue ia eeoa cieaeaiiyi e?eueeino? ND - 4 ? CD - 8, aea e ii?ooaiiyi ni?aa?aeiioaiiy oeeo ee?oei: cieaeaiiy noi?an?? i?e nainen?, oieneei - aea?a?/iiio aea?iaoeo? ? i?aeaeuaii? noi?an?? i?e neiae?ii? o?eaaeiai noeniaiiy. Oe? ci?ie aoee iiacycai? c? cieaeaiiyi e?eueeino? ?E - 2 iiceoeaieo ee?oei, ui a?aeia?aaeoaaei ii?ooaiiy eiiia?aoe?? CD - 3 ee?oei ? cieaeaiiy oeeoioiene/iino? ee?oei naeac?iee. Ci?iaiiy e?eueeino? Oe?E, ye i?iya iae?ioaaaeueii-e?ioioeeoa?ieo ii?ooaiue, niinoa??aaee o an?o oai?eo ia /an iinooiaiiy. Ae?oaei, iaeaaaeeea?oei eiiiiiaioii o oi?ioaaii? aeac?ioaa?aoe?? iaoaaie?cio o oai?eo a EN aaaaeaee ii?ooaiiy noaeeiii - o?iiaioeeoa?ii? eaiee. Oae, o?iiaioeeoiiai?y aoea ?aiiueith, a ?iiae? ?aeeiith iciaeith ii/eiath/iainy o?iiaiooai?aiiy. Iaeii/anii niinoa??aaee cieaeaiiy o?a?eiie?oe/ii? aeoeaiino? ieacie: o ?ac? naineno a 1,2 ?ace, o ?ac? OAAe a 1,5 ?ace, o ?ac? NON a 1,7 ?ace, i?aeaeuaiiy e?eueeino? o?a?eiiaaio o oai?eo ia nainen a 1,7 ?ace, i?e OAAe a 2,5 ?ace, i?e NON a 2,7 ?ace. Cieaeaiiy oiea?aioiino? ieacie aei aaia??ia o 1,2-1,6 ?ace aeicaieeei iina?aaeiuei i??eoaaoe i?i aeao?oeeo aioeo?iia?ia III ? caa?ico o?iiaiooai?aiiy o ?ac? naineno, OAAe oa NON. O?aoy a?oia ci?iaiue na?ae/eea i?i ii?ooaiiy iiiiieneaaiacii? eaiee ? i?iyaeyeanue aenieei eaeeioeeoa?iei ?iaeaenii ?ioieneeaoe?? ? ia?aiaoe?eiei ?iaeaenii oiene/iino?, a oaeiae i?aeaeuaiiyi e?eueeino? na?aaeiueiiieaeoey?ieo iaioeae?a, ui aoei oa?aeoa?iei aeey on?o oai?eo. Iaeiie/aiiy ai?aeo, na/iaeie, e?aaoei?io, i?aeaeuaiiy aeoeaiino? oa?iaio?a a?aeaeaaee aaiaoioiene/io ae?th - iioeiaeaeaiiy neioni?ae?a, iao?ioiene/io ae?th - ii?ooaiiy oe?e?niino? aiaeioae?th i?ieneiaeueieo eaiaeueoe?a c eieaeueiei a?aeeeaaeaiiyi a ieo o?a?eia. Ioaea, o an?o oai?eo anoaiiaeaia iaeiioeiia ni?yiiaai?noue a?io?i?/ieo oa ?ioiieia?/ieo ii?ooaiue, ye i?iya aiaeiaaiii? ?ioieneeaoe??. I?ioa, ioneia? iaoai?cie ?? ?icaeoeo aoee ??cieie, ui aecia/aei aeaye? oa?aeoa?i? ci?ie oeeo iieaciee?a caeaaeii a?ae ao?ieia?? e?eoe/iiai noaio. Oae, i?e nainen? ?i?oe?aoi?aie ca?eueiaiiy oeeoie?i?a ? i?e?iae, ?o oieneie ? aea?aaie. Aieiaia oi/ea ?o i?eeeaaeaiiy - aiaeioae?e noaeei ? oee?eoethth/? ee?oeie ?ioiiiai ?aaaoaaiiy. I?e OAAe iaoaaie?/i? ii?ooaiiy oi?iothoueny o a?aeiia?aeue ia aoii?aeuei? oeeoioiene/i? ?aaeoe??, eiee ca aioeaai aenooia? aaioai. Ai?aea?iaeueiee a?eeiaee oienei ni?ey? oi?aa?naeueiiio o?aaeaiith aiaeioae?th. I?e NON ii?ooaiiy iaoaaie?cio coiiaeai? ?oai?/ii - ?aia?ooc?eieie iaoai?ciaie aea?eueiaiiy ??ciiiai?oieo oeeoie?i?a. Oae, a ia??iae ?oai?? aeaiaoo?iaaiee a?eie icyc?a, iath/e aeanoeaino? aioeaaia, aa?a o/anoue o ii?ooaii? oe?e?niino? aiaeioae?th noaeei. A ?aia?ooc?eiiio ia??iae? i??i?eoaoieie noathoue i?ioeane ia?aeeniiai ieeneaiiy e?i?ae?a c iiaeaeueoith aeoeaaoe??th i?ioaac, e?ciniiaeueieo oa i?aaiiniaoeeo?/ieo oa?iaio?a. Oaeei /eiii noa? i/aaeaeiei, ui aiaeiaaiia ?ioieneeaoe?y, ye iaeaaaeeea?oee i?iya iie?i?aaiii? iaaeinoaoiino?, oi/a ? iaea ??ci? ioneia? iaoai?cie naiai oi?ioaaiiy a?aeiia?aeii aei ao?ieia?? EN, i?ioa aeoeaaoi?e ii?ooaiiy iaoaaie?cio - oeeoie?ie aoee iaeiioeiieie ? oi/eith i?eeeaaeaiiy ?o ia ia?oeo aoaiao oi?ioaaiiy iie?i?aaiieo ii?ooaiue aoa aiaeioae?e noaeei. I?aeoaa?aeaeaiiyi oeueiio neoaeeei aeine?aeaeaiiy e?eueeino? iaeaaaeeea?oiai oeeoie?ia - oaeoi?a iae?ico iooeeie (OII) aeueoa, ?ieue yeiai iniaeeai aaaeeeaa ye ioneiaiai oeeoie?ia a oi?ioaaii? NNCA. Anoaiiaeaii aeaa aa??aioe ci?iaiiy oeueiai iieacieea. Ia?oee aa??aio, eiee iieacieee OII aeueoa ia ii?yaeie ia?aaeuoaaee eiio?ieue 60,6±12,4 iea/ie ? neeaaeaee o oai?eo ia nainen 660,4±12,2 iea/ie, a o oai?eo ia oieneei-aea?a?/iee aea?iaoeo 450,2±16,7 iea/ie, na?ae/ea i?i iayai?noue oace iai?oaeaiiy NNCA. Oea i?aeoaa?aeaeoaaei a?aeiiee oaeo, ui iaeneeuei?oei ?iaeoeoi?ii OII ? i?iaeoeoe aaeoa??aeueiiai iioiaeaeaiiy - aiaeioieneie (e?iiiie?naoa?eaee), i?ioaiae?eaie aaeoa??aeueii? no?iee, i?ioa?i A, e?i?ae A oa ?io? eiiiiiaioe. Ae?oaee aa??aio ie ?icaeyaeaee ye i?iya ?ioiiia?ae?/o, ui oa?aeoa?eco? a?aenooi?noue ?aaeoe?? c aieo oai?iai ia aeno?aiaeueiee iiae?aciee. I?e oeueiio ??aaiue OII aeueoa neeaa o oai?eo ia nainen 35,7±2,9 iea/ia, a i?e oieneei - aea?a?/iiio aea?iaoeo?- 30,0±2,8 iea/ia. Iaiao?aeii a?aecia/eoe, ui ii?iaeueia ?ioiia a?aeiia?aeue ?, cie?aia i?ioean ?ic?ooaiiy ee?oei i?oai?a, i?aaenoaaeaieo i?e?iaieie ? aioeaaiieie aaaioaie, a oaeiae aiaeioieneiaie, iaiiaeeeaee i?e cieaeaiiio ??ai? ?E - 2 ? + , iacaaaeath/e ia iaaei??ia i?aeaeuaiiy OII aeueoa, ui ? i?aeoaa?aeaeo?oueny iaoeie aeaieie. I?iaaaeai? aeine?aeaeaiiy aeicaieeee aecia/eoe ?ieue OII aeueoa, ye aieiaiiai ?i?oe?aoi?a a oi?ioaaii? neiae?iio nenoaiii? caiaeueii? a?aeiia?ae? - iniiae ?icaeoeo iie?i?aaiieo ii?ooaiue. Aea/aiiy oa aiae?c ee?i?/ieo oa eaai?aoi?ieo iieaciee?a aeicaieea noi?ioethaaoe ee?i?/io oa?aeoa?enoeeo NNCA o oai?eo a e?eoe/iiio noai? ??cii? ao?ieia?? (Oaae.4.). Iaea?aeai? ?acoeueoaoe na?ae/aoue i?i oa, oi ?icaeoie neiae?iio nenoaiii? caiaeueii? a?aeiia?ae? ? iane?aeeii ae?? ??ciiiai?oieo aeno?aiaeueieo aieea?a o ?ac? naineno, OAAe oa NON ? iieyaa? a iniia? oi?ioaaiiy iie?i?aaiieo ii?ooaiue i?e oeeo caoai?thaaiiyo. Oaeei /eiii, iayai?noue neiae?iio nenoaiii? caiaeueii? a?aeiia?ae? aecia/aea i?noea ? ?ieue aiaeiaaiii? ?ioieneeaoe?? a oi?ioaaii? EN. Oea c iaeiiai aieo iiynithaaei iaaoaeoeai?noue o?aaeeoe?eii? ?ioaineaii? oa?ai??, a c ?ioiai - iio?aaoaaei iioei?caoe?? aeoeaieo iaoiae?a e?eoaaiiy aiaeiaaiii? ?ioieneeaoe??. Iioei?caoe?y ia?aaeaa/aea ?aoe?iiaeueia ii?aeiaiiy ? nai?/ania canoinoaaiiy aeoeaieo iaoiae?a onoiaiiy aiaeiaaiii? ?ioieneeaoe?? c o?aooaaiiyi ?? nooiino?, a oaeiae iaoai?ci?a e?eoaaeueii? ae?? eiaeiiai aeoeaiiai iaoiaeo. Oaaeeoey 4 Ee?i?/ia oa?aeoa?enoeea NNCA o oai?eo a e?eoe/iiio noai? ??cii? ao?ieia?? Ee?i?/i? iciaeeNainenOAAeNAeNIi?ooaiiy ooieoe?? na?oey, eaaaiue, ia/?iee, ie?ie, OeIN62%16%66%Ii?ooaiiy ooieoe?? na?oey, eaaaiue, ia/?iee aai ie?ie38%84%34%O?aaeaiiy oe??e15%100%96%Oao?iiia iiiaae 25 a 1 oa., iiaaiii?y, ?AeNAe+++AEA: oao?ea?ae?y > 90 oae/oa., aeeooci? ci?ie
i?iea?aea, cieaeaiiy aieueoaaea O-1, 2, 3; QRS+++A?ia?oa?i?/iee neiae?ii
oyaeeiai nooiaiy+++Ao?aoa aaae iiiaae 5 ea +—Eaithethaaiiy
iaa?no?aeueieo noaeei+++Canoinoaaiiy aioea?ioee?a+++Canoinoaaiiy
aetheiei?oeeinoa?i?ae?a-/++/—/+Aoaeoeai?noue ?ioaineaii? oa?ai??
i?ioyaii 7-10 aei?a—Eaeeioeeoe, 6,4±0,1
109/e15,9±2,211,8±0,812,1±1,3E?ioioeeoe,
26,5±0,3%15,5±1,613,6±1,515,9±1,1O?iiaioeeoe, 253,0±3,3
109/e146,0±9,2196,0±4,9182,0±12,2OIA, 56,0±0,1
ii/aiae.44,1±0,129,1±4,441,4±3,6E??, 1,01±0,015,2±0,97,1±0,87,6±0,7I?O,
1,08±0,016,04±0,546,08±0,155,48±0,26OII aeueoa, 60,6±12,4
iea/ia660,4±12,2450,2±16,7-?E -2 -? +, 10,50±0,81
%5,40±0,374,95±0,413,03±0,14

Oaeee aa??aio e?eoaaiiy iiaeaethaaa aeaoieneeaoe?eiee iioaioe?ae oeyoii
aeaeaeaiiy ?c e?iaioieo ia eeoa i?e?ia?a, ?o oienei?a ? aea?aai?a, aea e
aeniaaeaieo, c?oeiiaaieo ee?oei e?ia?, caeaeo oeeoie?i?a, o?a?eiiaaio,
?ioiieo eiiieaen?a, na?aaeiueiiieaeoey?ieo ie?aiiaioeae?a oa ?ioeo
oienei?a, caaacia/oth/e ?acenoaioi?noue aei ?ioaeoe?eieo aieea?a ?
iiia?aaeaeoth/e oi?ioaaiiy iaiai?ioieo ii?ooaiue.

O oai?eo ia nainen eiiieaen iioei?ciaaieo iaoiae?a aeeth/aa iaoiaee
onoiaiiy ?c e?iaioieo ? oeaiei i?e?ia?a, ?o oienei?a ? aioeaai?a ?
caaacia/oaaa ?ioii?aaoeyoe?th, a oaeiae iaa oeeoie?iei?eaoth/o ae?th.
Canoiniaoaaee ii?aeiaiiy ieaciaoa?aca c ieacianieaiiia?ooc??th,
aaiinieaiiia?ooc??th, oeueo?ao?ieaoiaa ii?ii?iaiiy aooie?ia?.

O oai?eo ia oieneei — aea?a?/iee aea?iaoeo iioei?caoe?y aeoeaieo
iaoiae?a e?eoaaiiy aiaeiaaiii? ?ioieneeaoe?? aeeth/aea ieaciaoa?ac o
niieo/aii? c ieacianieaiiia?ooc??th ? aaiinieaiiia?ooc??th, oae ye oea
caaacia/oaaei oaeaeea aeaeaeaiiy ?c e?iaioieo oeeoie?i?a ? aioeaai?a,
oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E), a oaeiae ni?eyei e?ea?aeaoe??
aiaeiaaiii? ?ioieneeaoe??.

I?e neiae?ii? o?eaaeiai noeniaiiy iioei?caoe?y aeeth/aea ia eeoa aea??
iaoiae?a, aea e ci?iaiiy oaeoeee ?o canoinoaaiiy, yea iieyaaea o oiio,
uia ia /aeaoe ?icaeoeo aeaeiiiainaoe?? aino?i? ie?eiai? iaaeinoaoiino?,
a canoiniaoaaoe eiiieaen o ii/aoeiaiio ia??iae?. C oe??th iaoith
aeei?enoiaoaaee aaiiae?ae?c c aaiiea?aiia?ooc??th, ieaciaoa?ac c
ieacianieaiiia?ooc??th, o oai?eo c ?ioaeoe?eieie oneeaaeiaiiyie a
eiiieaen iioei?ciaaieo iaoiae?a aeeth/aee oeueo?ao?ieaoiaa ii?ii?iaiiy
aooie?ia?.

sse eiiiiiaio iioei?ciaaiiai e?eoaaiiy o an?o oai?eo aoea aeei?enoaia
aano?iaioa?ini?aoe?y c iaoith iiia?aaeaeaiiy i?e?iaii? o?aineieaoe?? c
oeoieiai-eeoeiaiai o?aeoo.

Ii?aoeueiaai? iioei?ciaai? iaoiaee aoee neeaaeiaith /anoeiith
eiiieaenii? i?ia?aie ?ioaineaii? oa?ai??, yea aeeth/aea oae? a?oie
aca?iiiiacycaieo caoiae?a ye — onoiaiiy aeaea?aea (i?e/eie) EN oa
?ioaineaio oa?ai?th, ni?yiiaaio ia a?aeiiaeaiiy oa i?aeo?eieo
aaeaeaaoiiai e?iaiia?ao oa aeeoaiiy; eiina?aaoeai? iaoiaee ei?aeoe??
ii?ooaiue iaoaaie?cio (?iooc?eiee ?aaeei).

Iieacaiiyi aei canoinoaaiiy iioei?ciaaieo iaoiae?a o aea/aieo oai?eo
noaea iayai?noue ia iaio /ioe?ueio iciae NNCA (Oaae. 4).

?acoeueoaoe e?eoaaiiy ioe?ithaaee a aeaio a?oiao oai?eo: o ia?o?e
i?iaiaeeeanue o?aaeeoe?eia ?ioaineaia oa?ai?y, o ae?oa?e —
canoiniaoaaeenue iioei?ciaai? iaoiaee e?eoaaiiy aiaeiaaiii?
?ioieneeaoe?? (Oaae. 1,2,3). Anoaiiaeaii, ui canoinoaaiiy iioei?ciaaieo
iaoiae?a e?eoaaiiy caaacia/o?, iacaaaeath/e ia iie?i?aaii? ii?ooaiiy,
nei?i/aiiy o?eaaeino? ia??iaeo aiaeioieneeico i?e nainen? c 24 aei 12
ae?a, i?e oieneei — aea?a?/iiio aea?iaoeo? c 28 aei 18 ae?a, i?e
neiae?ii? o?eaaeiai noeniaiiy c 10 aei 14 ae?a (?en. 1.).

A naith /a?ao canoinoaaiiy iioei?ciaaieo aeoeaieo iaoiae?a e?eoaaiiy
aiaeiaaiii? ?ioieneeaoe?? ni?eyei cieaeaiith eaoaeueiino? o ?ac? naineno
c 32,4% aei 8%, o ?ac? oieneei-aea?a?/iiai aea?iaoeoo c 10,7% aei 4%, o
?ac? neiae?iio o?eaaeiai noeniaiiy c 37,7% aei 22,2% (?en.2.).

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?en. 1. O?eaae?noue ia??iaeo aiaeioieneeico, caeaaeii a?ae niiniao
e?eoaaiiy (aeiaa).

?en.2. Eaoaeuei?noue, caeaaeii a?ae niiniao e?eoaaiiy (%).

Oaeei /eiii, o?aooaaiiy iaoiaaiaco NNCA o ?icaeoeo e?eoe/iiai noaio i?e
nainen?, OAAe oa NON aeicaiey? oe?eani?yiiaaii aeei?enoiaoaaoe a
?ioaineai?e oa?ai?? iioei?ciaai? aeoeai? iaoiaee. Oe? iaoiaee ni?eyee
ciaioaiith neaaeino? oa ii?iae?caoe?? oaiia?aoo?e o?ea, e?ea?aeaoe??
iciiao, iie?ioaiith aiaoeoo, iiceoeai?e aeeiai?oe? AEA aeaieo o 56%
oai?eo ia nainen, 80% oai?eo ia OAAe oa o 34% oai?eo ia NON. O
iaoe??io?a ia naioe/iee aiaeiea?aeeo a i?ioean? canoinoaaiiy
iioei?ciaaieo aeoeaieo iaoiae?a ? i?ney aeienee (i?ioyaii 4-5 i?nyoe?a)
ca aeaieie AoiEA anoaiiaeaia iiceoeaia aeeiai?ea. O o?ueio oai?eo c 21
aaaaoaoe?? ia nooeeao eeaiai?a inoaoi/ii e?ea?aeoaaeenue i?ioyaii 5-6
i?nyoe?a aac iia?aoeaiiai e?eoaaiiy.

Ii?yae c iie?auaiiyi ee?i?/ieo iieaciee?a aeyaeai? iiceoeai? ci?ie
a?io?i?/ieo oa ?ioiieia?/ieo aeaieo (Oaae.1,2,3). Oae, i?e
o?aaeeoe?eiiio e?eoaaii? ?c 59 iieaciee?a o oai?eo ia nainen
iie?ioeeenue 32, i?e OAAe — 27, i?e NON — 16. I?ae /an aeei?enoaiiy
iioei?ciaaieo iaoiae?a a?aeiia?aeii — 42, — 47 ? 40 iieaciee?a.

AENIIAEE

1. Aea/aiiy ee?i?/ieo, a?io?i?/ieo oa ?ioiieia?/ieo iieaciee?a o oai?eo
a e?eoe/iiio noai? i?e nainen?, oieneei — aea?a?/iiio aea?iaoeo?,
neiae?ii? o?eaaeiai noeniaiiy aeicaieeei anoaiiaeoe o ieo iayai?noue
iie?i?aaiii? iaaeinoaoiino?. I?i oea na?ae/eei ii?ooaiiy ooieoe?? icyoe
i?aai?a o 62% oai?eo ia nainen, 16% oai?eo ia OAAe, 66% oai?eo ia NON, a
ii?ooaiiy ooieoe?? o?ueio i?aai?a aeyaeaii o 38% oai?eo ia nainen, 84%
oai?eo ia OAAe ? 34% oai?eo ia NON.

2. Anoaiiaeaii, ui aiaeiaaiia ?ioieneeaoe?y ? neeaaeiaith /anoeiith
iie?i?aaiieo ii?ooaiue, i?i ui na?ae/aoue ci?ie ee?i?/ieo, a?io?i?/ieo
oa ?ioiieia?/ieo ii?ooaiue o oai?eo a e?eoe/iiio noai? i?e nainen?,
OAAe, NON.

3. Noi?ioeueiaai? oa?aeoa?i? iniaeeaino? ee?i?/ieo, a?io?i?/ieo oa
?ioiieia?/ieo iieaciee?a o ?ac? e?eoe/iiai noaio na?aae oai?eo ia
nainen, oieneei — aea?a?/iee aea?iaoeo, neiae?ii o?eaaeiai noeniaiiy.
Anoaiiaeaii, ui oa?aeoa? ci?i caeaaeaa a?ae ao?ieia?? e?eoe/iiai noaio ?
aoa iiacycaiee c iayai?noth ?ioaeoe?eiiai eiiiiiaioo i?e nainen?,
oi?ioaaiiyi iane?aee?a oeeoioiene/ieo aea?a?/ieo ?aaeoe?e i?e OAAe,
?oai?/ii — ?aia?ooc?eieie iaoai?ciaie i?e NON.

4. Anoaiiaeai? caaaeuei? iciaee aiaeiaaiii? ?ioieneeaoe??, ye?
aeyaeythoueny iaeii/aniith aeac?ioaa?aoe??th iae?ioaaaeueii —
e?ioioeeoa?iiai eiiieaeno, noaeeiii — o?iiaioeeoa?ii? oa
iiiiieneaaiacii? eaiie aeaoieneeaoe??. E?eoe/iee noai o oai?eo ia
nainen, OAAe, NON noi?iaiaeaeoaaany iayai?noth neiae?iio nenoaiii?
caiaeueii? a?aeiia?ae?, yeee aaaaeaee aieiaiith i?e/eiith
aeac?ioaa?aoe?? iaeaaaeeea?oeo nenoai aeaoieneeaoe??.

5. Neiae?ii nenoaiii? caiaeueii? a?aeiia?ae? i?e e?eoe/iiio noai?, yeee
noi?iaiaeaeo? nainen, OAAe, NON oa?aeoa?eco?oueny, ii?yae c iaeiioeiieie
ee?i?/ieie i?iyaaie, oaeiae ci?iaie a?io?i?/ieo oa ?ioiieia?/ieo
iieaciee?a.

6. Anoaiiaeaii, ui niieo/aiiy /ioe?ueio aeacaieo iciae neiae?iio
nenoaiii? caiaeueii? a?aeiia?ae? ? aeinoaoi?i aeey iioei?caoe?? aeoeaieo
iaoiae?a e?eoaaiiy aiaeiaaiii? ?ioieneeaoe??. Iioei?caoe?y ia?aaeaa/aea
nai?/ania oa ?aoe?iiaeueia niieo/aiiy aeoeaieo iaoiae?a a?aeiia?aeii aei
nooiino? ? oyaeeino? aiaeiaaiii? ?ioieneeaoe??, a oaeiae o?aooaaiiy
iaoai?ci?a e?eoaaeueii? ae?? eiaeiiai aeoeaiiai iaoiaeo, oaeiae
aeicaieyea iiia?aaeeoe ?icaeoie iaiai?ioieo ci?i ? iie?auoaaea
?acoeueoaoe e?eoaaiiy oai?eo o e?eoe/iiio noai? ??cii? ao?ieia??.

7. Iiceoeaiee aieea iioei?ciaaieo aeoeaieo iaoiae?a e?eoaaiiy
aiaeiaaiii? ?ioieneeaoe?? ia ia?aa?a e?eoe/iiai noaio o oai?eo ia
nainen, oieneei — aea?a?/iee aea?iaoeo, neiae?ii o?eaaeiai noeniaiiy
aeyaeyany nei?i/aiiyi ia??iaeo aiaeioieneeico c 24 aei 12 ae?a o ?ac?
naineno, c 28 aei 18 ae?a o ?ac? OAAe, c 14 aei 10 ae?a o ?ac? NON, a
oaeiae cieaeaiiyi eaoaeueiino? c 32,4 aei 8 % o ?ac? naineno, c 10,7 aei
4 % o ?ac? oieneei-aea?a?/iiai aea?iaoeoo, c 37,4 aei 22, 2 % o ?ac?
neiae?iio o?eaaeiai noeniaiiy.

I?AEOE*I? ?AEIIAIAeAOe??

1. C iaoith ae?aaiinoeee aiaeiaaiii? ?ioieneeaoe?? i?ae /an e?eoe/iiai
noaio, coiiaeaiiai nainenii, OAAe, NON, aeioe?eueii aeei?enoaiiy
iieaciee?a: iae?ioaaaeueii — e?ioioeeoa?iiai eiiieaeno (eaeeioeeoe,
e?ioioeeoe, iaee/eiyaea?i? iaeo?io?ee, CD3, CD8, CD4/CD8, Oe?E, OII
aeueoa, ?E-2-?+), noaeeiii — o?iiaioeeoa?ii? (o?iiaioeeoe, o?a?eiiaai,
o?a?eiie?oe/ia aeoeai?noue) oa iiiiieneaaiacii? (E??, NII, ai?ae, ANO,
AEO, a?e??oa?i, na/iaeia, e?aaoei?i) eaiie.

2.Ae?aaiinoeeo aiaeiaaiii? ?ioieneeaoe?? o oai?eo a e?eoe/iiio noai?
o?aaa i?iaiaeeoe ia /an iinooiaiiy ? ia 12-24 aeiao o ?ac? naineno, ia
12-21 aeiao o ?ac? OAAe ? ia 10-14 aeiao o ?ac? NON.

3.Neiae?ii nenoaiii? caiaeueii? a?aeiia?ae? o?aaa aaaaeaoe ioneiaei
iaoai?ciii oi?ioaaiiy iie?i?aaiieo ii?ooaiue.

4.Iniiaieie ae?aaiinoe/ieie e?eoa??yie NNCA o aea/aieo oai?eo ?:
eaeeiiai?y iaioa 3 A/e aai eaeeioeeoic iiiaae 12 A/e; e?ioiiai?y iaioa
16 %; cieaeaiiy oaeoi?a iae?ico iooeeie aeueoa iaioa 50 iea/ie aai
iiiaae 100 iea/ie; ciaioaiiy e?eueeino? ?aoeaioi??a aei ?ioa?eaee?io — 2
iaioa 4%; o?iiaioeeoiiai?y iaioa 160 A/e aai o?iiaioeeoic iiiaae 240
A/e; i?aeaeuaiiy eiioeaio?aoe?? o?a?eiiaaio iiiaae 4 a/e; ca?eueoaiiy
e?eueeino? na?aaeiueiiieaeoey?ieo iaioeae?a iiiaae 0,3 iaeeieoe?
iioe/ii? u?eueiino?; oee?eoethth/eo ?ioiieo eiiieaen?a iiiaae 150
iea/ie; i?aeaeuaiiy eaeeioeeoa?iiai ?iaeaeno ?ioieneeaoe?? iiiaae 2 ?
ia?aiaoe?eiiai ?iaeaeno oiene/iino? iiiaae 3.

5.E?eoaaiiy NNCA i?ae /an e?eoe/iiai noaio ioneoue ia?aaeaa/aoe
eiiieaenia aeei?enoaiiy iioei?ciaaieo iaoiae?a e?eoaaiiy aiaeiaaiii?
?ioieneeaoe?? c iaoith iiia?aaeaeaiiy iaiai?ioiino? ? iie?auaiiy
?acoeueoao?a e?eoaaiiy.

6.Iieacaiiyi aei canoinoaaiiy iioei?ciaaieo iaoiae?a e?eoaaiiy
aiaeiaaiii? ?ioieneeaoe?? ? iayai?noue ye i?i?ioi /ioe?ueio iciae NNCA.

7.Aeey oai?eo a EN, coiiaeaiiio nainenii, aeioe?eueii niieo/aiiy
ieaciaoa?aco c ieacianieaiiia?ooc??th, aaiinieaiiia?ooc??th,
oeueo?ao?ieaoiaei ii?ii?iaiiyi aooie?ia?.

8.I?e EN, coiiaeaiiio OAAe, iioei?caoe?y iiaeiia aeeth/aoe ieaciaoa?ac o
niieo/aii? c ieacianieaiiia?ooc??th oa aaiinieaiiia?ooc??th.

9.Iioei?caoe?y e?eoaaiiy oai?eo NON ia?aaeaa/a? nai?/ania ?
?aoe?iiaeueia niieo/aiiy aaiiae?ae?co ? aaiiea?aiia?ooc??, ieaciaoa?aco
? ieacianieaiiia?ooc??, oeueo?ao?ieaoiaiai ii?ii?iaiiy aooie?ia?.

10.Aeey iiia?aaeaeaiiy i?e?iaii? o?aineieaoe?? c oeoieiai-eeoeiaiai
o?aeoo iaiao?aeii aeei?enoaiiy aano?iaioa?ini?aoe??, ye eiiiiiaioa
iioei?ciaaiiai e?eoaaiiy o an?o aea/aieo oai?eo.

11.Iioei?ciaai? iaoiaee iooooue aooe neeaaeiaith /anoeiith eiiieaeniiai
e?eoaaiiy, yea aeeth/a?: onoiaiiy aeaea?aea (i?e/eie) EN ? ?O,
ni?yiiaaio ia a?aeiiaeaiiy aaeaeaaoiiai e?iaiia?ao, aeeoaiiy oa
iaoaaie?cio.

12.Aeey iiia?aaeaeaiiy ? nai?/aniiai e?eoaaiiy aaiiaeeiai?/ieo ?iceaae?a
o oai?eo ia nainen iaiao?aeii aeeiiaiiy AoiEA.

NIENIE IIOAE?EIAAIEO I?AOeUe

1. Iiaeeiaa ?. E., Oaii A. I., Aeaeiaeaeoa O. A., Ocoi A. A., Eiaaeiaiei
E. A., Ianoa?aiei A. I., Ci?eiaa A. A. Eeeieei-ii?oieiae/aneia
iainiiaaiea aeaoieneeaoeee i?e ?aaaeiieieeca // A?oea eeeie/aneie e
yenia?eiaioaeueiie iaaeeoeeiu.-1995.-O.4, ? 1.- C.34-38.

2. Oaii A. I., Atheueiaiaaeia O. E., Ianoa?aiei A. I., Aeaeiaeaeoa O.
A., Ci?eiaa A. A. Aa?eaiou ea/aiey e?eoe/aneeo ninoiyiee n o/aoii
iaoiaaiaca SIRS- neiae?iia nenoaiiiai ainiaeeoaeueiiai ioaaoa //
Aianoaceieiaey e ?aaieiaoieiaey.-1997.- ? 6.- N.48-53.

3. Oaii A. I., Ae?aii?e A. I., Ci?eiaa I. A., Ianoa?aiei I. I.,
Aeaeiaeaeoa O. A., Aiaaeai. ?. ?. Iiaee i?aeo?ae aei ae?aaiinoeee
?ioiieo ii?ooaiue i?e e?eoe/ieo noaiao // Iaaee/i? ia?niaeoeae. — 1997 —
Oii II, ? 4.- N.25-29.

4. Oaii A. I., Aeaeiaeaeoa, O. A., Ianoa?aiei, A. I. Ci?eiaa. A. A.
Eiiieaen-

iia ea/aiea oieneei-aeea?ae/aneeo ii?aaeaiee eiaee n o/aoii nenoaiiiai
ain-

iaeeoaeueiiai ioaaoa // A?oea eeeie/aneie e yenia?eiaioaeueiie
iaaeeoeeie.

— 1998 — O. 7, ? 2.- N.169 — 173.

5. Oaii A. I., Ianoa?aiei A. I., Othiaioeaaa N. A., Eiaaeiaiei E. A.,
O?aiaiei A. E., Aeaeiaeaeoa O.A. I?eioeeiu eniieueciaaiey yooa?aioiuo
iaoiaeia i?e e?eoe/aneeo ninoiyieyo // Oac. aeiee. I eiiapano
aianoaciieiaia-paaiiiaoieiaia Oepa?ie. “Aeooaeueii ipiaeaie
aianoaciieiaii oa paaiiiaoieiaii”. — Caiipiaeaey .- 1992. — N. 133.

6. Iiaeeiaa ?. E., Oaii A. I., Ianoa?aiei A. I., Aeaeiaeaeoa O. A.,
Cipeiaa A. A. Iiaue iiaeoiae e aeeaaiinoeea yiaeiaaiiie eioieneeaoeee
ipe epeoe/aneeo ninoiyieyo // Iaoapeaeu IV Anapinneeneiai nuacaea
aianoaceieiaia e paaieiaoieiaia. — Iineaa, 1994. — N. 238 — 239.

7. Novikova R. I., Shano V. P., Nesterenko A. N., Dzhodzhua T. V.
Nosocomial sepsis: a view to intensive care // 9th European Congress of
Anaesthesiology: Abstracts. — Jerusalem, Israel, October 2-7, 1994.- P.
421.

8. Shano V. P., Nesterenko A. N., Dzhodzhua T. V. Nosocomial infection —
a factor of priority formation of multiple organ failure in sepsis //
8th European Congress of ICM. Athens-Greece, October 18-22, 1995.-
Abstracts: Intencive Care Medicine, 1995. — Vol. 21. — Suppl. 1. — P. —
18.

9. Oaii A. I., Ae?aiiee A. I., Ci?eiaa A. A., Aeaeiaeaeoa O. A.,
Ianoa?aiei A. I., Aiaaeai E. E. Aeeaaiinoeea eiioiieiae/aneeo ia?ooaiee
i?e oe?o?ae/aneii nainena // Iaoa?iaee 2 iaoeiiiaeueiiai eiia?ano
aianoaciie. Oe?a?ie: VII c’?cae aianoaciieiaia Oe?a?ie. 24-27 aa?aniy
1996 ?. i. Oa?eia. — Eeia, 1996.- N. 142-143.

10. Shano V. P., Nesterenko A. N., Dzhodzhua T. V., Zorkova E.V.
Intensive care of MOSF: role of efferent methods in prevention of
internal irreversible changes // 11th World Congress of
Anaestesioligists, 14-20 April, 1996. Sydney, Australia. Abstract Book.
— Sydney, 1996. — P.371.

IAOAIO IA AEIAO?Ae

1. Iaoaio ? 93006896 Oe?a?ia, IIE 6 A61E35/28. Niin?a aooi?ioiiei?aeoe??
i?e e?eoe/ieo noaiao / A. I. Oaii, ?. ?. Iia?eiaa, O. A. Aeaeiaeaeoa, I.
I. Ianoa?aiei, I. A. Ci?eiaa. — ? 200034; Cayae. 01.03.93.; Iioae.
25.12.97., Athe. ? 6.

AIIOAOe?ss

Aeaeiaeaeoa O. A. Iioei?caoe?y aeoeaieo iaoiae?a e?eoaaiiy aiaeiaaiii?
?ioieneeaoe?? o oai?eo i?ae /an e?eoe/ieo noai?a — ?oeiien.

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeaoa iaaee/ieo iaoe
ca niaoe?aeuei?noth 14.01.30-aianoac?ieia?y oa ?ioaineaia oa?ai?y. —
Aei?i?iiao?ianueea aea?aeaaia iaaee/ia aeaaeai?y, Aei?i?iiao?ianuee,
1998.

Aeena?oaoe?th i?enay/aii ieoaiiyi ianoaaeaiiy oa e?eoaaiiy oai?eo, ye?
ciaoiaeyoueny o e?eoe/ieo noaiao. Anoaiiaeaii, ui oa?aeoa? ? iniaeeaino?
ci?i iieaciee?a iaoaaie?cio oa ?ioi?oaoo caeaaeaoue a?ae ao?ieia??
e?eoe/iiai noaio ? oa?aeoa?ecothoueny neiioiiieiiieaenii nenoaiii?
caiaeueii? a?aeiia?ae?. Canoinoaaiiy iioei?ciaaieo aeoeaieo iaoiae?a
e?eoaaiiy aiaeiaaiii? ?ioieneeaoe?? aeicaiey? cieceoe eaoaeuei?noue, a
oaeiae nei?ioeoe ia??iae aiaeioieneeico o ?ac? naineno,
oieneei-aea?a?/iiai aea?iaoeoo, neiae?iio o?eaaeiai noeniaiiy.

Eeth/ia? neiaa: e?eoe/iee noai, neiae?ii nenoaiii? caiaeueii?
a?aeiia?ae? (NNCA), iioei?caoe?y e?eoaaiiy.

AIIIOAOeEss

Aeaeiaeaeoa O.A. Iioeiecaoeey aeoeaiuo iaoiaeia ea/aiey yiaeiaaiiie
eioieneeaoeee o aieueiuo i?e e?eoe/aneeo ninoiyieyo. — ?oeiienue.

Aeenna?oaoeey ia nieneaiea o/?iie noaiaie eaiaeeaeaoa iaaeeoeeineeo iaoe
ii niaoeeaeueiinoe 14.01.30 — aianoaceieiaey e eioaineaiay oa?aiey. —
Aeiai?iiao?ianeay ainoaea?noaaiiay iaaeeoeeineay aeaaeaiey,
Aeiai?iiao?iane, 1998.

Aeenna?oaoeey iinayuaia aii?inai ianeaaeiaaiey e ea/aiey aieueiuo
iaoiaeyueony a e?eoe/aneeo ninoiyieyo.

Onoaiiaeaii, /oi oa?aeoa? e iniaaiiinoe eciaiaiey iieacaoaeae
iaoaaieecia e eiioieoaoa caaenyo io yoeieiaee e?eoe/aneiai ninoiyiey e
oa?aeoa?ecothony neiioiiieiiieaenii neiae?iia nenoaiiiai
ainiaeeoaeueiiai ioaaoa. I?eiaiaiea iioeiece?iaaiiuo aeoeaiuo iaoiaeia
ea/aiey yiaeiaaiiie eioieneeaoeee iicaieyao nieceoue eaoaeueiinoue, a
oaeaea nie?aoeoue ia?eiae yiaeioieneeica i?e nainena,
oieneei-aeea?ae/aneii aea?iaoeoa, neiae?iia aeeeoaeueiiai naeaaeaiey.

Eeth/aaua neiaa: e?eoe/aneia ninoiyiea, neiae?ii nenoaiiiai
ainiaeeoaeueiiai ioaaoa (NNAI), iioeiecaoeey ea/aiey.

SUMMARY

Aezhodzhua O. V. Optimization of active methods of treatment of
endogenous intoxication in cases in critical states. — Manuscript.

The dissertation on competition of a scientific degree of the candidate
of medical sciences (PhD) on a speciality 14.01.30 -anaestesiology and
intensive care. — Dniepropetrovsk State Medical Academy,
Dniepropetrovsk, 1998.

The dissertation is devoted to the problems of examination and intensive
care of the cases in critical states. In had been proved that character
and the features of changes of metabolism and immunity depend from
ethiology of critical state and are characterized by symptom — complex
of Systemic Inflammatory Response Syndrome. The application of optimized
active methods of intensive care of endogenous intoxication allows to
decrease the lethality level, to reduce the endotoxicosis period in
sepsis, toxico — allergic dermatitis, crush — syndrome.

Key words: critical state, endogenous intoxication, Systemic
Inflammatory Response Syndrome (SIRS), optimization of intensive care.

I?aei. aei ae?oeo 06.11.1998 ?. Oi?iao 60o84/16. Iai?? ion.

Ae?oe ion. Oiia. Ae?oe. A?e. 2,5. Oiia. Oa?a.-a?aea. 1,0.

Iae.-aeae. A?e. 1,78. Oe?aae 100 i?ei. Cai.55.

Iaae?oeiaaii OIA “Aaaa — i?eio”.

340023, i. Aeiiaoeuee — 23, aoe. Oi?aa?neoaonueea, 48.

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