Морфофункціональний стан тимуса, кісткового мозку та селезінки щурів після впливу імунотропних лікарських засобів: Автореф. дис… канд. біол. наук /

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Oa?iii?euenueea aea?aeaaia iaaee/ia aeaaeai?y

?i. ?.ss.Ai?aa/aanueeiai

Aea?aa Oaoyia Aieiaeeie??aia

OAeE [591.441-591.443-591.11]:615.015.044

II?OIOOIEOe?IIAEUeIEE NOAI

OEIONA, E?NOEIAIAI IICEO OA NAEAC?IEE UO??A

I?NEss AIEEAO ?IOIIO?IIIEO E?EA?NUeEEO CANIA?A

14.03.01. — ii?iaeueia aiaoii?y

Aaoi?aoa?ao aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

eaiaeeaeaoa a?ieia?/ieo iaoe

Oa?iii?eue — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia o Oa?e?anueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie

Iaoeiaee ea??aiee: Aeieoi? iaaee/ieo iaoe, i?ioani?

Ianeianueeee Na?a?e TH???ae/,

Oa?e?anueeee aea?aeaaiee
iaaee/iee oi?aa?neoao,

caa?aeoaa/ eaoaae?e oeeoieia??, a?noieia?? ? aia??ieia??.

Io?oe?ei? iiiiaioe:

Aeieoi? a?ieia?/ieo iaoe, i?ioani? Noa/aiei Ethaeieea Ieaenaiae??aia,

OeIAeE Iaoe?iiaeueiiai iaaee/iiai oi?aa?neoaoo ?i.I.I.Aiaiiieueoey,

caa?aeoaa/ eaai?aoi??? aeaeo?iii? i?e?ineii??.

Aeieoi? iaaee/ieo iaoe, i?ioani? Aieiaaoeueeee Aiae??e Noaiaiiae/,

Oaeai?iaenueeee aea?aeaaiee oi?aa?neoao, caa?aeoaa/ eaoaae?e ii?iaeueii?
aiaoii??, iia?aoeaii? o??o?a?? ? a?noieia?? iaaee/iiai oaeoeueoaoo.

I?ia?aeia onoaiiaa: Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao,

eaoaae?a ii?iaeueii? aiaoii??, IIC Oe?a?ie, i. Eoaainuee

Caoeno aeena?oaoe?? a?aeaoaeaoueny » 23 » /a?aiy 1999 ?ieo i 14
aiaeei? ia can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee E 58.601.01. o
Oa?iii?euenuee?e aea?aeaai?e iaaee/i?e aeaaeai?? ?i. ?. ss.
Ai?aa/aanueeiai (282001, i. Oa?iii?eue, Iaeaeai Aie?,1).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Oa?iii?euenueei?
aea?aeaaii? iaaee/ii? aeaaeai?? ?i. ?.ss.Ai?aa/aanueeiai (282001, i.
Oa?iii?eue, aoe. ?onueea,12).

Aaoi?aoa?ao ?ic?neaiee » 22 » o?aaiy 1999 ?.

A/aiee nae?aoa? niaoe?ae?ciaaii? a/aii? ?aaee,

aeieoi? iaaee/ieo iaoe, i?ioani?
E?O I.I.

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. A inoaii? ?iee a ee?i?/i?e i?aeoeoe? i?iaaaeaiiy
?ioiiei?aeoe?? aeeeeeaa ana a?eueoee ?ioa?an (?.A. Aou??i,1996; I.O.
Caa?iaenueeee, 1997; A.A. Aeaenae/ee, 1998). Oea iia’ycaii ?c
ca?eueoaiiyi /enea caoai?thaaiue c ?ioiiei eiiiiiaioii o no?oeoo??
caaaeueii? caoai?thaaiino?, c ?iciianthaeaeaiiyi aoi?eiieo
?ioiiaeao?oeeoieo noai?a, ye? i?eaiaeyoue aei ?ioaeoe?eieo oneeaaeiaiue,
ui iinyoue caoyaeiee ? o?ii?/iee oa?aeoa? (I.A. Aiae?ae/ei,1998). Aeey
Oe?a?ie oey oaia iaaoaa? ia o?eueee /enoi iaaee/iiai, aea e
nioe?aeueiiai oa?aeoa?o o ca’yceo c oei, ui, ie??i caa?oaeiaiiy
iaaeieeoiueiai na?aaeiaeua, aeniain?? A?*-?ioaeoe?? (A.?. ?oaaeue,
1997), ianaeaiiy iaoi? e?a?ie i?iaeiaaeo? a?ae/oaaoe iane?aeee aaa??? ia
*i?iiaeeuenuee?e AAN. Iaeiei c iaeaaaeeea?oeo ?acoeueoao?a o?ii?/ii?
ae?? ?aae?aoe??, ye a?aeiii, ? i?eai?/aiiy ?ioi?oaoo ( I.?. Nai?i, 1997;
C.N. Oeenoiaa,1998; I.A. Ai?oei ? ni?aaao., 1998; A.N. Aieiaaoeueeee,
1998).

Aeey ae??oaiiy i?iaeaie ei?aeoe?? ii?ooaiue ?ioi?oaoo i?iaiaeeoueny
aaaaoi aeine?aeaeaiue c aieeao ??cieo e?ea?nueeeo cania?a ia noai
?ioiii? nenoaie (I.TH. Eoe?eiaa,1997; ?.?. Ia?eia,1998; ?.A.
ss?aia,1998; ?.I. Iaeei, 1999). I?ioa, oe? aeai? iaea?aeai?, ye i?aaeei,
a ?acoeueoao? ooieoe?iiaeueiiai, a ia ii?oieia?/iiai i?aeoiaeo aei
ae??oaiiy i?iaeaie ?, /ano?o ca ana, iaiaaeothoueny aecia/aiiyi
?ioiieia?/ieo aeanoeainoae e?ia? (Taimadge I.D.,1997; ?.A. Iao?ia, 1997;
I.A. Ii?iciaa, 1998; I.N. Aiaothe, 1999). Oae? aeine?aeaeaiiy ia
iiaeooue aooe iiaieie aac aea/aiiy ii?oieia?/iiai noaio
?ioiieiiiaoaioieo i?aai?a, ui aeicaieeei a anoaiiaeoe eieae?caoe?th oa
?ioaineai?noue ?ioiieo ia?aaoaeia.

Iino?eii noai?ththoueny iia? ?ioiio?iii? e?ea?nuee? caniae, aei yeeo
aoiaeyoue ? ??ciiiai?oi? e?ea?nuee? oi?ie ia iniia? noanoaioe?e
?ineeiiiai iioiaeaeaiiy. ?acii c oeei, a?aenooi? a?aeiiino? i?i
no?oeoo?i? ci?ie a ?ioiieiiiaoaioieo i?aaiao i?ney canoinoaaiiy oaeeo
i?aia?ao?a (O.?. Eieyaea ? ni?aao., 1997). Ia cono??ee ie oaeiae ?
?ia?o, aea a i?iaiaeeany ii??aiyeueiee ii?oieia?/iee aiae?c noaio
?ioiieiiiaoaioieo i?aai?a i?ae aieeaii i?aia?ao?a ??ciiai iioiaeaeaiiy.

A?noeiao — iiaee iai?aneioaoe/iee i?aia?ao, noai?aiee o AeIOeEC ia
iniia? Oieiiieoe? Aaeeaeuenueei?, ia? i?ioecaiaeuei? oa
aioei?ie?oa?aoeai? aeanoeaino?, caeaoiee cieaeoaaoe nooi?iue
niaoeeo?/iiai ?ioiieia?/iiai caiaeaiiy, ?aeiiaiaeiaaiee aeey e?eoaaiiy
caiaeueieo i?ioean?a c aea?a?/iei eiiiiiaioii. Iaeiae, aeine?aeaeaiiy,
i?enay/ai? ii?oieia?/iei ? ooieoe?iiaeueiei ci?iai oeiono, e?noeiaiai
iiceo ? naeac?iee i?e ae?? a?noeiaoo ia i?iaiaeeeenue. A?aenooi? oaeiae
a?aeiiino? ? i?i ii??aiyeueiee aiae?c ii?oieia?/ieo ci?i oeeo i?aai?a
i?e ae?? o?aaeeoe?eieo ?ioiio?iiieo cania?a. I?ioa, oae? aeai?
iaiao?aei?, ai aeicaieythoue a?eueo eaae?o?eiaaii aiai?eoe i?i ia?aaaae
oiai /e ?ioiai i?aia?aoo.

Ana oea ?iaeoue i?iaeaio noai?aiiy ?aeeiiai i?aeoiaeo aei ioe?iee noaio
?ioiii? nenoaie o e?ea?nuee?e oieneeieia??, iiooeo iiaeo oa?iaeieia?/ieo
cania?a ?aaoethaaiiy ooieoe?e ?ioi?oaoo iniaeeai aeooaeueiith.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oaia
aeena?oaoe?? caoaa?aeaeaia A/aiith ?aaeith Oa?e?anueeiai iaaee/iiai
oi?aa?neoaoo IIC Oe?a?ie (i?ioieie ?6 a?ae 19 o?aaiy 1994?.) ? ?
o?aaiaioii ieaiiai? iaoeiai-aeine?aeii? ?iaioe Aea?aeaaiiai iaoeiaiai
oeaio?o e?ea?nueeeo cania?a (i. Oa?e?a) (N aea?aeaaii? ?a?no?aoe??
0193U041077, 0193U041086) a?aeiia?aeii aei Iinoaiiae EI Oe?a?ie N573
a?ae 8.10.92 ?. «I?i ?icaeoie iaaee/ii?, aaoa?eia?ii? oa
i?e?ia?ieia?/ii? i?iieneiaino?, iie?auaiiy caaacia/aiiy ianaeaiiy ?
iio?aa oaa?eiieoeoaa o e?ea?nueeeo caniaao, iaaee/iith ? aaoa?eia?iith
oaoi?eith»

Iaoa aeine?aeaeaiiy. Aea/eoe iniaeeaino? ii?oiooieoe?iiaeueiiai noaio
oeiona, e?noeiaiai iiceo oa naeac?iee uo??a a oiiaao aieeao a?noeiaoo,
?iaeiiaoaoeeio oa eaaai?cieo a??ioei?eaeo.

Caaaeaiiy aeine?aeaeaiiy:

1. Aeyaeoe no?oeoo?i? oa oeueo?ano?oeoo?i? ci?ie a oeion? oa ciiao
?aiiioeyoe?? O-e?ioioeeo?a o naeac?ioe? uo??a i?e ae?? a?noeiaoo,
?iaeiiaoaoeeio ? eaaai?cieo a?ae?ioei?eaeo.

2. Ioe?ieoe ooieoe?iiaeuei? iniaeeaino? ?aoeaioi?iiai aia?aoo
O-e?ioioeeo?a uo??a a oiiaao ae?? a?noeiaoo, ?iaeiiaoaoeeio ? eaaai?cieo
a?ae?ioei?eaeo.

3. Aea/eoe ii?oieia?th e?noeiaiai iiceo oa cii ?aiiioeyoe??
A-e?ioioeeo?a o naeac?ioe? uo??a i?e ae?? a?noeiaoo, ?iaeiiaoaoeeio ?
eaaai?cieo a?ae?ioei?eaeo.

4. Aecia/eoe ?ioiieia?/i? aeanoeaino? A-e?ioioeeo?a i?e ae?? ia i?aai?ci
uo??a a?noeiaoo, ?iaeiiaoaoeeio ? eaaai?cieo a?ae?ioei?eaeo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa aeaia oa?aeoa?enoeea
ii?oiooieoe?iiaeueiiai noaio oeiona, e?noeiaiai iiceo oa naeac?iee uo??a
i?ney ae?? iiaiai e?ea?nueeiai caniao a?noeiaoo, noai?aiiai ia iniia?
Oieiiieoe? Aaeeaeuenueei?.

Anoaiiaeaii, ui i?aia?ao ia? ?ioiio?iiio ae?th, yea i?iyaey?oueny, a
ia?oo /a?ao, o ae?? ia aoii?aeueio eaieo ?ioi?oaoo.

Iieacaii, ui, ia caaaeath/e ia iaae?aaeai?noue e?ioioeeoiiiaco a oeion?,
aeniea ooieoe?iiaeueia aeoeai?noue ai?oae?i?aoeeoey?iiai eiiiiiaioo
caaacia/o? iiaiioe?iia aec??aaiiy oa aeeoa?aioe?thaaiiy oeiioeeo?a.

A ?iaio? i?aeoaa?aeaeaii oaeo i?i iayai?noue ?ioiio?iiieo aeanoeainoae o
?iaeiiaoaoeeio oa eaaai?cieo a?ae?ioei?eaeo. Aia?oa c aeiiiiiaith
eiiieaeno ii?oieia?/ieo iaoiae?a aeine?aeaeaiiy aea/aiee noai oeiona,
e?noeiaiai iiceo oa naeac?iee uo??a i?ney ae?? oeeo i?aia?ao?a.

Aia?oa aenia?eiaioaeueii aeiaaaeaii, ui a?noeiao, eaaai?cieo
a?ae?ioei?eae oa ?iaeiiaoaoeei iathoue ??ciini?yiiaaio ae?th noiniaii
ie?aieo eaiie ?ioiii? nenoaie uo??a.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Aeai?, iaea?aeai? a
?acoeueoao? aeine?aeaeaiiy a?noeiaoo, a oaeiae ?iaeiiaoaoeeio oa
eaaai?cieo a?ae?ioei?eaeo, ? iniiaith aeey ?icoi?iiy iaoai?cio
?ioiio?iiii? ae?? oeeo i?aia?ao?a, ui, a naith /a?ao, ? ia?aaeoiiaith
aeey ?o ee?i?/iiai canoinoaaiiy i?e aea??eia?e ?ioiiei?aeoe?? ??cieo
ii?ooaiue ?ioiii? nenoaie.

Iaoiaee aeine?aeaeaiiy i?aai?a ?ioiii? nenoaie eaai?aoi?ieo oaa?ei
ai?iaaaeaeaii a ?iaioo Oeaio?aeueii? iaoeiai-aeine?aeii? eaai?aoi???
Oe?a?inueei? oa?iaoeaaoe/ii? aeaaeai??.

Iniaenoee aianie caeiaoaa/a. Caeiaoaa/ai cae?eniaii ?ic?iaeo iniiaieo
oai?aoe/ieo oa i?aeoe/i?o iieiaeaiue ?iaioe. Naiino?eii i?iaaaeaii
na?oeiiioe/ia, ?ioiiii?oieia?/ia oa ii?oiiao?e/ia aeine?aeaeaiiy
ii?oiooieoe?iiaeueiiai noaio oeiona, e?noeiaiai iiceo oa naeac?iee uo??a
a oiiaao ae?? ?ioiio?iiieo e?ea?nueeeo cania?a. Aaoi?ii i?iaaaeaii
aiae?c ? ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiiy, noi?ioeueiaai? an?
iieiaeaiiy ? aeniiaee, oa ai?iaaaeaeaii eiiieaen iaoiaeee aeey
aeine?aeaeaiiy ?ioiii? nenoaie eaai?aoi?ieo oaa?ei.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeenue ia 1 Iaoe?iiaeueiiio c’?cae? oa?iaeieia?a Oe?a?ie
(Iieoaaa, 1995), iaoeiai-i?aeoe/i?e eiioa?aioe?? «Iaoeia? aeine?aeaeaiiy
oa i?iaeaie ae?iaieoeoaa e?ea?nueeeo cania?a» (Oa?e?a, 1995), ia
can?aeaiiyo Oa?e?anueeiai oiaa?enoaa aiaoii?a, a?noieia?a ? aia??ieia?a
(1999), ia ni?eueiiio can?aeaii? eaoaae?e a?noieia??, oeeoieia?? ?
aia??ieia?? Oa?e?anueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo oa
Oa?iaeieia?/ii? eii?n?? A/aii? ?aaee Aea?aeaaiiai iaoeiaiai oeaio?o
e?ea?nueeeo cania?a (1999).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaaii 9 iaoeiaeo i?aoeue, ?c
ieo 4 noaoo? o oaoiaeo iaoeiaeo aeaeaiiyo, 5 – a ca??ieeao, iaoa??aeao
? oacao eiioa?aioe?e, ye? iiai?noth a?aeia?aaeathoue ci?no i?iaaaeaieo
aeine?aeaeaiue.

Ianya oa no?oeoo?a aeena?oaoe??. Iaoa??aee aeena?oaoe?? aeeeaaeai? ia
145 noi??ieao iaoeiiieniiai oaenoo. Aeena?oaoe?y neeaaea?oueny ?c
anooio, iaeyaeo e?oa?aoo?e, ?icae?eo «Iaoa??aee oa iaoiaee
aeine?aeaeaiue», ?icae?eo aeanieo aeine?aeaeaiue, ?icae?eo «Aiae?c oa
ocaaaeueiaiiy ?acoeueoao?a aeine?aeaeaiue», aeniiae?a, i?aeoe/ieo
?aeiiaiaeaoe?e ? nieneo e?oa?aoo?e. ?iaioa ?ethno?iaaia 10 oaaeeoeyie,
63 ?enoieaie, aeei?enoaii 220 e?oa?aoo?ieo aeaea?ae (152 – e?a?i NIAe,
68 – ?ioeo e?a?i).

CI?NO ?IAIOE

Iaoa??ae oa iaoiaee aeine?aeaeaiue. Ia’?eoii aeine?aeaeaiiy aoee 120
naioe?a a?eeo iae?i?eieo eaai?aoi?ieo uo??a ianith 200 a, a?eii 3
i?nyoe?, ye? oo?eioaaeenue a noaiaea?oieo oiiaao a?aa??th Aea?aeaaiiai
iaoeiaiai oeaio?o e?ea?nueeeo cania?a. Oaa?eie ?iciiae?eyeenue ia 4
a?oie ii 30 uo??a o eiaei?e: ia?oa a?oia — ?ioaeoi? oaa?eie; ae?oaa,
o?aoy ? /aoaa?oa a?oie — oaa?eie, yeei aaiaeeee a?aeiia?aeii oaaeaoee
a?noeiaoo ii 0,15 a, ?iaeiiaoaoeeio ii 0,025 a, eaaai?cieo
a?ae?ioei?eaeo ii 0,15 a. Aaaaeai? aeice a a?aiao ia e?eia?ai iane
oaa?ei neeaaeaee (a ia?a?aooieo ia ae?th/? noanoaioe??): 0,5 a/ea
a?noeiaoo, 1,0 ia/ea ?iaeiiaoaoeeio, 30 ia/ea eaaai?cieo a?ae?ioei?eaeo.
Aeice aoee aecia/ai? ye aoaeoeai? oa?aiaaoe/i? aeey aeaiiai aeaeo
oaa?ei a aenia?eiaioao, ye? ia oa?eoee aei oe??? ?iaioe.

Iaoa??aeii aeey ii?oieia?/iiai aeine?aeaeaiiy aoee oeion, e?noeiaee
iicie oa naeac?iea ?ioaeoieo uo??a oa uo??a, ye? caciaee ae??
aeuaiacaaieo i?aia?ao?a.

Aaoaiac?th oaa?ei i?iaiaeeee oeyoii aeaeai?oaoe??. I?ney ?icoeio
a?oaeii? ? /a?aaii? ii?iaeiei aeaeaeyee oeion, a?oaeeio ? naeac?ieo.
Oeion ? naeac?ieo caaaeoaaee c oi/i?noth aei 1o10 –6 ea, aecia/aee ?o
?ici??e (aeiaaeeia, oe?eia) c oi/i?noth aei 1o10-2 i. Aeey
a?noieia?/iiai aeine?aeaeaiiy aeei?enoiaoaaee oiaoi/ee oeaio?aeueieo oa
ia?eoa??eieo a?aeae?e?a naeac?iee (0,5 o 0,5 10 i-2) oa aanue oeion.
E?noeiaee iicie caae?aee ?acii c a?oaeeiith (0,5 o 1,0 10-2 i). Iaoa??ae
o?enoaaee a 10 % iaeo?aeueiiio oi?iae?i?, aeey aeyaeaiiy
?eaiioeeaii?ioa?ae?a — a ??aeei? Ea?ioa. A?oaeeie aeaeaeueoe?iioaaee a
?ic/ei? 5% io?aoeii? eeneioe (1i ?ic/ei) (?.E?ee?, 1969). Aanue iaoa??ae
i?ney i?iaaaeaiiy ii nie?oai aeno?aeii? eiioeaio?aoe?? caeeaaee a
oeaei?aeei-ia?ao?i. C??ce caaoiaoee 5-7 iei oa?aoaaee aaiaoienee?iii ?
aiceiii, aeey aeyaeaiiy ?II noaaeee ?aaeoe?th A?aoa (eiio?ieue c
e?enoae?/iith ?eaiioeeaacith i?e 37i N i?ioyaii 2 aiaeei). Aeey
aeyaeaiiy iae?ioaa?a aeei?enoiaoaaee OEE-?aaeoe?th (eiio?ieue c
ai?eacith) (?.E?ee?, 1969). Ii?oieia?/i? aeine?aeaeaiiy i?iaiaeeee i?ae
i?e?ineiiii «A?iai ?-12» i?e ca?eueoaii? o125, o200, o400.

Aeeoa?aioe?eia aea/aiiy O- ? A-e?ioioeeo?a i?iaiaeeee i?yiei ? iai?yiei
iaoiaeaie Eoina ia ia?ao?iiaeo c??cao. Aeei?enoiaoaaee iiiieeiiaeuei?
aioeo?ea na??? ?EI («IaaeA?iNiaeo?») 10, 30, 31, 86, 90, 91, AI-1. sse
ethi?i?noeaioio i?oeo aeei?enoiaoaaee F(aa)2-o?aaiaioe e?iey/eo aioeo?e
i?ioe ieoa/eo ?ioiiaeiaoe?i?a, iii?/aieo O?OOe. C??ce oaeiae ?ieoaoaaee
i?yiei iaoiaeii Eoina c iiiiniaoeeo?/ieie ethi?i?noeaioieie (iii?/aieie
O?OOe) ne?iaaoeaie i?ioe Ig A, I, G, N-3 o?aeoe?? eiiieaiaioo. Neai?ioee
aeaioiaeyee a IAe? ai?aeai?ieia?? oa i?e?ia?ieia?? ?i.Aaiaeay (i.
Iineaa). Ne?iaaoee i/euaee ia/?ieiaei ii?ioeii, a ia ?ioeo c??cao
noaaeee eiio?ieuei? ?aaeoe?? niaoeeo?/iiai aeieoaaiiy (E. Eaaa? oa
?i.,1990). I?aia?aoe aea/aee a ethi?i?noeaioiiio i?e?ineii? IE-2 c
aeei?enoaiiyi na?oeio?eueo??a ON-1-2, N?N-24, AN-8-2, OON-6-3.

Oeueo?ano?oeoo?ia oa?aeoa?enoeea ee?oei iaea?aeaia i?e aeei?enoaii?
iaoiaeo o?aini?n?eii? aeaeo?iiii? i?e?ineii??. Ia?iaeo iaoa??aeo
i?iaiaeeee ca noaiaea?oiith iaoiaeeeith (I.A.Aieeiaa, 1987). Iaoa??ae
o?enoaaee a 2 %-iio aeooa?iaiioaeueaeaa?ae? ia oinoaoiiio aooa?? (?I
7,3-7,4) i?ioyaii 2-3-o aiaeei, iio?i i?iieaaee a oinoaoiiio aooa?? (?I
7,3-7,4), iinoo?enoaaee a 1%-io ieneae? ini?th ia oinoaoiiio aoaa?? (?I
7,3-7,4), ciaaiaeithaaee a nie?oao aeno?aeii? eiioeaio?aoe??, aoeaoii?,
caeeaaee a aiii-a?aeaeeo. Oeueo?aoiie? c??ce eiio?anooaaee
o?ai?e-aoeaoaoii, oeeo?aoii naeioeth ? aiae?coaaee a aeaeo?iiiiio
o?aini?n?eiiio i?e?ineii? (AAI-THA?).

I?iaiaeeee ii?oiiao??th i?aai?a ca aeiiiiiaith ieoey?ii? e?i?eee, n?oee
A.A.Aaoaiae?eiaa, ieoey?-i?e?iiao?a oa oaeaa?c?eiiai aiae?caoi?a
ii?oieia?/ieo iniaeeainoae ee?oei «?ioaa?ae 2I» (A.A.Aaoaiae?eia, 1990).
I?e aeine?aeaeaii? oeiono aecia/aee a?aeiini? ia’?ie ei?eiai? oa
iiceiai? ?a/iaei, i?ae?aoiaoaaee u?euei?noue ei?oeeaeueieo oa
iaaeoey?ieo oeiioeeo?a o iie? ci?o i?e?ineiio ieiuath 410-6 ii2,
e?euee?noue oei?/ieo o?eaoeue o i/c o 200. I?e ii?oiiao??? naeac?iee
aei??yee aaeeeee oa iaeee ae?aiao?e e?ioi?aeieo aoceee?a, ?o
aa?i?iaoeaieo oeaio??a, ia?e- a?oa??aeueieo O-cii. I?ae?aoiaoaaee
u?euei?noue ee?oei a O- ? A-ciiao a?ei? ioeueie ? a /a?aii?e ioeuei? c
i/c ieiuath 4o10-6 ii2 . A e?noeiaiio iiceo i?ae?aoiaoaaee u?euei?noue
ee?oeiieo aeaiaio?a a i/c ieiuath 4 o10-6 ii2 (oaae. 1).

Oaaeeoey 1

No?oeoo?a ii?oiiao?e/ieo aeine?aeaeaiue

OeionNaeac?ieaE?noeiaee iicie-aecia/aiiy a?aeiinieo ia’?i?a e??eiai? ?
iiceiai? ?a/iaeie

-aecia/aiiy u?eueiino? eeeoei a oiiai?e iaeeieoe? ieiu? e??eiai? e
iiceiai? ?a/iaeie

— i?ae?aooiie e?eueeino? oei?- /ieo o?eaoeue a iie? ci?o i?e?ineiia
200- aecia/aiiy na?aaeiueiai ae?aiao?o e?ioi?aeiiai oie?eoea,
ia?ea?oa??aeueieo O-cii, aa?i?iaoeaieo oeaio??a

— aecia/aiiy u?eueiino? eeeoei a oiiai?e iaeeieoe? ieiu?
ia?ea?oa??aeueii? ciie, aa?i?iaoeaiiai oeaio- ?o, iaio?eii? ciie,
/a?aiii? ioeueie- aecia/aiiy u?eueiino? ee?oei a oiiai?e iaeeieoe? ieiu?
e?noeiaiiiceiai? ii?iaeieie

Noaoenoe/io ia?iaeo iaea?aeaieo aeaieo i?iaiaeeee caaaeueiii?eeiyoeie
iaoiaeaie, ioe?ithth/e a??ia?aei?noue ia ??ai? cia/eiino? ia iaioa 95%
(? 0,05) ca e?eoa???i Nouethaeaioa.

?ACOEUeOAOE AeINE?AeAEAIUe OA ?O IAAIAI?AIIss

No?oeoo?ii-ooieoe?iiaeuei? iniaeeaino? oeiona uo??a a ii?i? oa i?ney
aieeao a?noeiaoo, ?iaeiiaoaoeeio oa eaaai?cieo a?ae?ioei?eaeo. A ii?i?
oeion uo??a ia? /?oea ?iciiae?eaiiy /anoie ia iiceiao oa ei?eiao
?a/iaeio, ianya yei? ia?aaaaea?.

I?e a?noieia?/iiio aeine?aeaeaii? oeion?a uo??a i?ney ae?? a?noeiaoo
aeyaeaii ia?aaaaeaiiy iiceiai? ?a/iaeie iaae ei?eiaith, a oaeiae
oaiaeaioe?th aei i?aeaeuaiiy u?eueiino? ei?oeeaeueieo oeiioeeo?a
(oaae.2). Noiniaii iaaeoey?ieo oeiioeeo?a, iiaeia a?aecia/aoe, ui
u?euei?noue ?o ?icoaooaaiiy a?ae eiio?ieueieo iieaciee?a ia
a?ae??ciy?oueny. Iiae?aia iaiai?oaeai?noue e?ioioeeoiiiaco /anoeiai
i?aeoaa?aeaeo?oueny iayai?noth a?eueo iaeii??aeiiai neeaaeo oeiioeeo?a:
iac??e? iiia?aaeieee O-e?ioioeeo?a c aioeaaiii Thy-1 aeyaeythoueny
noaeainoey?ii o aeaeyae? aocueeiai eaioethaeea. Ia?aaaaeathoue na?aaei?
oa iae? e?ioioeeoe ??ciiai nooiaiy c??eino? c aioeaaiii CD-5, iaeeie/i?
CD-3 cono??/athoueny ii an?e ia?aio?i? oeiona. Aeaeo?iiiii?e?ineii?/ii
/ano?oa niinoa??aaee oaeiae iae? e?ioioeeoe, aeey yeeo oa?aeoa?ia
iayai?noue ie?oaeiai yae?a c 1 aai 2 yaea?oeyie oa oe?ieei iaiaeii
aaoa?io?iiaoeio, a?aeii? i?aaiaeaie oeeoiieacie. Aeey oeion?a uo??a
aeaii? a?oie oa?aeoa?ia i?ie?oa?aoe?y ai?oae?i?aoeeoey?iiai eiiiiiaioo c
iciaeaie eiai aeniei? ooieoe?iiaeueii? aeoeaiino?. I?i oea na?ae/eoue
ca?eueoaiiy a?coaeueii? u?eueiino? ai?oae?i?aoeeoeioeeo?a oa c?inoaiiy
e?eueeino? oei?/ieo o?eaoeue a iaiaaeai?e ieiuei? c??co. Iaeii/anii
ca?eueoothoueny ?o ?ici??e, c’yaeythoueny e?noiiiae?aiici?iai? oi?ie c
ae?aaeaiei ea?aoicii, aeeno?io?/iei eaeueoeeiicii. I?i i?aeaeuaiiy
aeoeaiino? ai?oae?i?aoeeoey?ieo ee?oei caeice na?ae/eoue oaeiae aenieee
ai?no OEE-iiceoeaiiai iaoa??aeo ye o oei?/ieo o?eueoeyo, oae ? a
neiieanoao ai?oae?i?aoeeoeioeeo?a, ye? neeaaeathoue oa?aeoa?i?
«aei??aeee» i?ae o?eueoeyie. Ia i?yio caeaaei?noue ooieoe?iiaeueii?
aeoeaiino? ai?oae?i?aoeeoeioeeo?a oa ?ioaineaiino? OEE-?aaeoe?? aeaco?
N.ss. ?oa?iooaei (1997). O ?icoe?aieo aioo??oiuei/anoi/eiaeo
ia?eaaneoey?ieo ii?iaeieiao oeion?a uo??a aeaii? a?oie c’yaeythoueny
CD22 A-e?ioioeeoe, cono??/aeeny ieaciioeeoe c Ig M, G, A oa N-3 o?aeoe??
eiiieaiaioo. sse a?aeiii, e?ioi?aeia oeaieia ia?eaaneoey?ieo ii?iaeiei
ia ? ?noeiith ia?aio?iith i?aaio ? neoaeeoue i?aeoaa?aeaeaiiyi
noeioeyoe?? A-eaiee ?ioi?oaoo (I.A. Neaeueia ? ni?aao., 1996). Ne?ae
a?aecia/eoe ae?aaeai?noue iae?ioaa?/ii? ?aaeoe?? (10-12 ee?oei i?ioe 6-7
ee?oei o eiio?ie?), ui i?aeoaa?aeaeo?oueny aeaeo?iiiii?e?ineii?/ii ?
aeyaey?oueny ?ioiiiii?oieia?/iei iaoiaeii ca aeiiiiiaith IEA ?EI-AI-1.
I/aaeaeii iaae?aaeaiee ii??aiyii c eiio?ieai e?ioioeeoiiiac ia oii?
aeniei? ooieoe?iiaeueii? aeoeaiino? ai?oae?i?aoeeoey?ieo ee?oei ia
caaaaea? aeic??aaiith ? aeeoa?aioe?thaaiith ei?oeeaeueieo oeiioeeo?a.

Oaaeeoey 2

Ii?oiiao?e/i? iieacieee oeiona

A?oia niinoa?aaeaiue

A?aeiini? ia’?ie (%)U?euei?noue oeiioeeo?a a oiiai?e iaeeieoe? ieiu?
(ee?oei)E?euee?noue oei?/ieo o?eaoe a iie? ci?o o 200
(ee?oei)Ei?eIiceiai? ?a/iaeieEi?eIiceiai? ?a/iaeieEiio?ieue55,80
3,3544,20 3,0519,20 1,8412,40 1,182-4A?noeiao41,20 1,11*58,80
3,15*24,80 2,3513,20 1,944-5?iaeiiaoaoeei43,10

2,44*57,10

3,88*11,10

1,08*17,50

1,12*4-6Eaaai?ciea a?ae?ioei?eae

50,90

4,3549,10

3,8429,40

3,05*18,45

2,04*2-4I?ei?oee:

1. *- a?aei?iiino? aeinoia??i? a?aeiinii eiio?ieth (? 0,05)

2. e?euee?noue oaa?ei (n) aei??aith? 10 a eiaei?e a?oi? niinoa?aaeaiue

A oeion? uo??a i?ney ae?? ?iaeiiaoaoeeio aeyaeaii ca?eueoaiiy aaae
oeiona o ii??aiyii? c eiio?ieai, ui ia i?aeoaa?aeaeo? aeaieo e?oa?aoo?e
(I.A. Iai/eoeia ? ni?aao., 1997; I.?. Ii?iciaa ? ni?aao., 1998).
Iiaeeeai oey ??cieoey iiynith?oueny oei, ui ?io? aaoi?e aeine?aeaeoaaee
i?aiaoaeueiee aieea ?iaeiiaoaoeeio ia nenoaio iaoe — ieaoeaioa – ie?ae.
I?e a?noieia?/iiio aea/aii? a?aecia/a?oueny ciaioaiiy a?aeiioaiiy
ei?a:iiceiaa ?a/iaeia, a oaeiae cieaeaiiy u?eueiino? ei?oeeaeueieo
oeiioeeo?a ca oiiaii? iaeeieoe? ieiu? (oaae.2). Oea iiaea aooe coiiaeaii
ye ci?iith i?ioean?a i?a?aoe?? e?ioioeeo?a c oeiono, iineeaiiyi ?o
?oeioaaiiy, oae ? aaeueioaaiiyi i?ie?oa?aoe??, iia’ycaiei ?c cieaeaiiyi
nae?aoi?ii? aeoeaiino? i?aaio. Inoaii? i?eiouaiiy ni?inoiao?oueny oei,
ui i?aeoe/ii a on?o niinoa?aaeaiiyo noaeainoey?ia ciia ?icoe?aia aei 4-8
?yae?a iac??eeo iiia?aaeiee?a O-e?ioioeeo?a c aioeaaiii Thy-1, ye?
aeathoue yne?aai iiceoeaio ?aaeoe?th ia ?II. Aei iciae iineeaiiy
i?ie?oa?aoeaieo i?ioean?a iaeaaeeoue ? iiyaa oie?eoeiiiae?aieo no?oeoo?
o aioo??oi?e cii? ei?e, ye? neeaaeathoueny, aieiaiei /eiii, ?c na?aaei?o
oeiioeeo?a. ??aaiue aiiioico aeaui i?aeaeuaiee ii??aiyii c eiio?ieai, ui
aeyaey?oueny ? aeaeo?iiiii?e?ineii?/ii o aeaeyae? ina?aaeea c 6-8
oeiioeeo?a c iciaeaie ea??ii?eiico, ea??i?aeneno oa ea??ie?ceno. Iniiao
iiceiai? ?a/iaeie neeaaeathoue c??e? CD3, CD4 oa CD8-e?ioioeeoe,
u?euei?noue ?icoaooaaiiy yeeo ca oiiaii? iaeeieoe? ieiu? i?aeaeuaia
(oaae.2). Oea, ii?yae ?c aeayeith ?iaa?n??th oa??a, neoaeeoue
aeiaaaeaiiyi iineeaii? i?a?aoe?? e?ioioeeo?a c ei?e aei iiceiai?
?a/iaeie. Ne?ae a?aei?oeoe, ui ? a ei??, ? a iiceia?e ?a/iaei? ciaioaia
iiioeyoe?y ee?oei-noi?ani??a c aioeaaiii CD8, ui aeyaey?oueny
?ioiiii?oieia?/ii. On? oe? i?ioeane a?aeaoaathoueny ia oii? aeineoue
aenieiai nooiaiy i?ie?oa?aoe?? ai?oae?i?aoeeoey?iiai eiiiiiaioa, ui
i?iyaey?oueny o ca?eueoaii? a?coaeueii? u?eueiino? ai?oae?ioeeo?a c
ooai?aiiyi c ieo «aei??aeie», c?inoaiiyi e?eueeino? oei?/ieo o?eaoeue,
a?eueo?noue c yeeo ciaoiaeeoueny a aeoeaiiio noai?.
Aeaeo?iiiii?e?ineii?/ii aecia/a?oueny aaee/acia e?euee?noue
ai?oae?i?aoeeoeioeeo?a c oa?aeoa?ieie aioo??oiueiee?oeiieie nae?aoi?ieie
eaiaeueoeyie. A ia?eaaneoey?ieo ii?iaeieiao iiceiai? ?a/iaeie
cono??/aeeny aeoeaiaai? O- ? A-e?ioioeeoe, a oaeiae ee?oeie c Ig I ? N-3
o?aeoe?? eiiieaiaioo. ??aeoa, i?ae o eiio?ie? oa ?ioeo a?oiao
niinoa?aaeaiue, cono??/aeeny ee?oeie c Ig G. Aeaiaioe aaiaoi-oei?/iiai
aa?’??o ciaoiaeyoueny o noai? ooieoe?iiaeueii? aeoeaiino?. A
i?eaaneoey?ieo i?inoi?ao aeaeo?iiiii?e?ineii?/ii aeia?a aeaeii eiioaeo
aiaeioae?ioeeo?a noaeeiieo no?iie c e?ioioeeoaie ?
ai?oae?i?aoeeoeioeeoaie, ye? ni?eythoue i?a?aoe?? e?ioioeeo?a.

I?ney aieeao eaaai?cieo a?ae?ioei?eaeo aeyaeaii ia?inoaiiy iane caeice
i?e iaci?iaieo ?ioeo i?aaiiiao?e/ieo iieacieeao. Oe? aeai?
ni?aiaaeathoue c iayaieie a e?oa?aoo?? (A.I.?na?aa, 1996;
I.A.Ieai?aanueeee, 1990) A oeionao niinoa??aa?oueny oaiaeaioe?y aei
caeeaeaiiy a?aeiinieo ia’?i?a ei?e ? iiceiai? ?a/iaeie, a iniiaiiio, ca
?aooiie caoaeaiiy aioo??oiuei? ei?oeeaeueii? oa ei?oeeiiaaeoey?ieo cii.
O ?yae? niinoa?aaeaiue (ye i?aaeei a iaeeo /anoeao c oanoii/aoeie
e?ayie) ia iiaeia ?ic??cieoe iiae?e /anoie ia ei?o ? iiceiao ?a/iaeio.
Oea noi?iaiaeaeo?oueny ?icoe?aiiyi noaeainoey?ii? ciie, aaaaoi?
iiia?aaeieeaie O-e?ioioeeo?a c aioeaaiii Thy-1, ye? oa?aeoa?ecothoueny
iai?oaeaiiyi iaoaaie?/ieo i?ioean?a. Inoaii? niinoa??aa?oueny a
?ioaineaiino? ?aaeoe?? ia ?II. I?ae /an on?o niinoa?aaeaiue
ca?eueoo?oueny u?euei?noue ei?oeeaeueieo ? iaaeoey?ieo oeiioeeo?a ca
oiiaii? iaeeieoe? ieiu?. I?e oeueiio a iiceia?e ?a/iaei? ca?eueoo?oueny
e?euee?noue iac??eeo iiia?aaeiee?a O-e?ioioeeo?a, ui i?aeoaa?aeaeo?oueny
aeaeo?iiiii?e?ineii?/ii ? ?ioiiii?oieia?/ii. A ei?eiaiio oa??
niinoa??aa?oueny aeayea iaa?aeiia?aei?noue i?ae ??aiai u?eueiino? ee?oei
oa ?ioaineai?noth ?o aiiioico. Aeaeo?iiiii?e?ineii?/ii a?aecia/aeeny
iiiaeeiie? ae?eyiee, ye? neeaaeathoueny c 3-4 ee?oei ?c yaeuaie
?iciaaeo no?oeoo? ? iaieiiie. Ua iaeia iniaeea?noue oeion?a aeaii?
a?oie iieyaa? o cao?eioe? ?icaeoeo ai?oae?i?aoeeoey?iiai eiiiiiaioa, ui
i?iyaey?oueny o a?coaeueiiio ciaioaii? e?eueeino? aeeoocii ?icoaoiaaieo
ai?oae?i?aoeeoeioeeo?a ? iaaaeee?e e?eueeino? oei?/ieo o?eaoeue a
iaiaaeaiiio iie? ci?o c??co. Iaiaaii, iai?oaeaiiee e?ioioeeoiiiac ia
oii? cao?eiee aiiioico oa iaaeniei? ai?iiiaeueii? aeoeaiino?
ai?oae?i?aoeeoey?iiai eiiiiiaioa oeiono i?ecaiaeeoue aei oiai, ui
ii?ooo?oueny i?ioean aec??aaiiy oa aeeoa?aioe?thaaiiy oeiioeeo?a ?
/anoeia iiia?aaeiee?a O-e?ioioeeo?a c aioeaaiii Thy-1 iaaeoiaeeoue aei
iiceiai? ?a/iaeie ? oeioncaeaaeii? ciie naeac?iee.

No?oeoo?ii-ooieoe?iiaeuei? iniaeeaino? e?noeiaiai iiceo uo??a a ii?i? ?
i?ney aieeao a?noeiaoo, ?iaeiiaoaoeeio oa eaaai?cieo a?ae?ioei?eaeo.

A e?noeiaiio iiceo ?ioaeoieo uo??a u?euei?noue ?icoaooaaiiy ee?oeiieo
aeaiaio?a a oiiai?e iaeeieoe? ieiu? neeaaea? 10,2100,436 ee?oei. No?iee
aaiicieo neion?a aenoaeai? iecueeeie aiaeioae?ioeeoaie, ui ?icoaoiaai?
ia oiie?e OEE-iiceoeai?e iaia?ai?.

I?ney ae?? a?noeiaoo a e?noeiaiio iiceo uo??a a?noieia?/ia ea?oeia
na?ae/eoue i?i ia?aaaaeaiiy i?ioean?a i?a?aoe?? A-ee?oei iaae ?o
i?ie?oa?aoe??th. U?euei?noue ee?oeiieo aeaiaio?a ieae/a eiio?ieueieo
iieaciee?a ? noaiiaeoue 6,8100,244 ee?oei Neione ?icoe?ai?, ?o
aiaeioae?aeuei? ee?oeie iaa?yee?, o i?ina?o? aecia/athoueny ee?oeii?
aeaiaioe. Oea ei?aeth? c iiyaith A-e?ioioeeo?a a oeion? oa
?icoe?aiiyi e?ioi?aeieo aoceee?a o naeac?ioe?.

A e?noeiaiio iiceo uo??a i?ney ae?? ?iaeiiaoaoeeio iayai? on? iciaee
iineeaiiy e?ioioeeoiiiaco: ee?oeiia u?euei?noue ca oiiaii? iaeeieoe?
ieiu? a c??c? ia?aaeuo? eiio?ieueiee iieaciee, neeaaeath/e 18,410,64
ee?oei. Oea a?aeaoaa?oueny ia oii? aeoeaieo i?a?aoe?eieo i?ioean?a — o
i?ina?oeo neion?a aecia/athoue aaeeeo e?euee?noue e?ioioeeo?a.

I?ney ae?? eaaai?cieo aeyaeythoueny a?eueo /enaeuei? (o ii??aiyii? c
eiio?ieai) neione, no?iee yeeo ooai?ai? iaa?yeeeie aiaeioae?ioeeoaie,
?icoaoiaaieie ia OEE-iiceoeai?e iaia?ai?. A i?ina?oeo neion?a
niinoa??aa?oueny aaeeea e?euee?noue ee?oeiieo aeaiaio?a. U?euei?noue
i??ei?aeieo aeaiaio?a ca oiiaii? iaeeieoe? ieiu? c??co
e?noeiai-iiceiai? oeaieie ia?aaeuo? eiio?ieueiee ??aaiue ? neeaaea?
22,50 1,12 ee?oei. Ana oea ia aeicaiey? iai iiaiaeeoeny c ?nioth/ith
aeoieith i?i oa, ui eaaai?cie ia aieeaa? ia aoii?aeueio eaieo ?ioi?oaoo
? a?aeiiaeth? eeoa iaaeinoaoi?e ee?oeiiee ?ioi?oao (I.A. Ieaa?aanueeee
? ni?aaao., 1997).

No?oeoo?ii-ooieoe?iiaeuei? iniaeeaino? naeac?iee uo??a a ii?i? ? i?ae
aieeaii a?noeiaoo, ?iaeiiaoaoeeio oa eaaai?cieo a?ae?ioei?eaeo. A ii?i?
a naeac?ioe? uo??a a?ea ioeueia i?aaenoaaeaia e?ioi?aeieie aoceeeaie,
i?ieneiaeueieie oa aeenoaeueieie ia?ea?oa??aeueieie e?ioi?aeieie
ioooaie.

I?e i?e?ineii?/iiio aeine?aeaeaii? naeac?iee uo??a i?ae aieeaii
a?noeiaoo aeyaeaii ?icoe?aiiy e?ioi?aeieo aoceee?a, ca?eueoaiiy
ee?oeiii? u?eueiino? a iaio?ei?e cii? (oaae.3). Ia?aaaaeaee c??e?
CD22-ee?oeie, /ano?oa, i?ae o eiio?ie?, cono??/aeeny ieaciioeeoe c
Ig A, M, G, C-o?aeoe?? eiiieaiaioo ? iae?ioaa?/i? ee?oeie c
ai?eacino?eeith noanoaioe??th o oeeoiieaci?. Iniiaiei iaoai?ciii o
oi?ioaaii? ye A-, oae ? O-cii naeac?iee aecia?oueny i?a?aoe?y oeeo
ee?oei oa ?o iiia?aaeiee?a c oeiono oa e?noeiaiai iiceo (C.N.Oeenoiaa,
1998). Iaeiae, ye a?aeiii, ca?eueoaiiy O- ? A-cii a ia?eoa?e/ieo i?aaiao
?ioiii? nenoaie iiaea a?aeaoaaoenue ca ?aooiie iineeaii? i?a?aoe?? O- ?
A-ee?oei c a?aeiia?aeieo oeaio?aeueieo i?aai?a, ca ?aooiie i?ie?oa?aoe??
«naneeueieo» e?ioioeeo?a, ui a?eueo oa?aeoa?ii aeey A-ee?oeiii?
iiioeyoe??, a oaeiae ca ?aooiie ii?aeiaiiy ia?oiai ? ae?oaiai. A aeaiiio
aeiaaeeo oaeo i?a?aoe?? i?aeoaa?aeaeo?oueny oaiaeaoe??th aei
aonoiee?oeiiino? /a?aiii? ioeueie, oiio ui ee?oeiiee iai?i i?ae
oeaio?aeueieie e?ioi?aeieie i?aaiaie oa naeac?ieith cae?enith?oueny
/a?ac neione /a?aiii? ioeueie (C.N.Oeenoiaa, 1998). Ia
aeeeth/a?oueny, ui o o?aoeie aoceee?a (oai, aea aecia/athoueny
i?ina?oeai? aa?i?iaoeai? oeaio?e) a?aeaoaa?oueny ? i?ie?oa?aoe?y
«naneeueieo» ee?oei. Ii?oiiao?e/i? iieacieee ia?ea?oa??aeueii? ciie
caa?aaeai? ia eiio?ieueiiio ??ai?: ia?aaaaeaee O-e?ioioeeoe c
aioeaaiii CD3 (c??ea iiioeyoe?y). C??aeea cono??/aeeny O-e?ioioeeoe
??ciiai nooiaiy c??eino? c aioeaaiii CD5.

Oaaeeoey 3

Ii?oiiao?e/i? iieacieee naeac?iee

A?oia niinoa?a-aeaiueNa?aaei?e ae?aiao? (iei)U?euei?noue ee?oei a
oiiai?e iaeeieoe? ieiu? (ee?oei)e?ioi?- aeiiai

oie?eoea

O-ciieaa?i?iaoeaiiai oeaio?oO-ciieaa?i?iaoeaiiai oeaio?oiai-oeeii?
ciie/a?aiii? ioeueieEiio?ieue12,130 ,7885,110 0,5253,480
0,35018,410 0,4369,310 0,34417,30 0,2414,330 0,543A?noeiao14,81
0,87*5,210 0,5783,580 0,35419,210 0,5348,710 0,334*18,45 0,3415,610
0,785?iaeiiaoa-oeei

15,40 0,944*7,210

0,744*4,210

0,44821,80

0,55*9,80

2,4419,44

0,3314,410

0,644Eaaai?ciea a?ae?ioei?eae 18,50

1,11*5,120

0,5759,180

0,745*18,210 0,34511,310

0,454*18,38

0,3414,95

0,68I?ei?oee:

1. *- a?aei?iiino? aeinoia??i? a?aeiinii eiio?ieth (? 0,05)

2. e?euee?noue oaa?ei (n) aei??aith? 10 a eiaei?e a?oi? niinoa?aaeaiue

I?ae aieeaii ?iaeiiaoaoeeio ia i?e?ii?aiaoao niinoa??aa?oueny ae?aaeaia
c?inoaiiy ?ici???a e?ioi?aeieo aoceee?a (oaae.3), coiiaeaia ca?eueoaiiyi
ia?ea?oa??aeueii?, iaio?eii? oa ia?a?iaeueii? cii. Naia oai
a?aeaoaathoueny i?ioeane eiio?ieth e?ia?, yea i?io?ea?, ee?oeiia oa
noaee?oeiia aeeoa?aioe?thaaiiy, eiiia?aoeaia aca?iiae?y O- ?
A-e?ioioeeo?a c oaaioeeooth/eie aioeaai iae?ioaaaie, i?iaeoeoe?y
«naneeueieo» e?ioioeeo?a (R.M. Binnds ? ni?aao.,1996; I.I. Ee??yiia,
1998).

Iaeii/anii c ?icoe?aiiyi O-cii c?inoa? ? u?euei?noue a ieo c??eeo CD 3
O-e?ioioeeo?a, ui, i/aaeaeii, coiiaeaii ia o?eueee i?ie?oa?aoe??th
«naneeueieo» ee?oei, aea e i?aeneeaiith i?a?aoe??th O-e?ioioeeo?a c
oeiono. A ciiao ?aiiioeyoe?? A-e?ioioeeo?a oaeiae ca?eueoaia u?euei?noue
?icoaooaaiiy ee?oei (oaae.3), na?aae yeeo aeineoue /anoi cono??/athoueny
iiia?aaeieee A- e?ioioeeo?a c Ig I. A oie aea /an, ee?oeie c Ig G
cono??/athoueny cia/ii ??aeoa, i?ae o eiio?ie?. Iae?ioaa?/ia ?aaeoe?y
i?eai?/aia.

I?e i?e?ineii?/iiio aeine?aeaeaii? naeac?iee uo??a i?ney ae?? eaaai?cieo
a?ae?ioei?eaeo aeyaey?oueny ae?aaeaia ca?eueoaiiy aa?i?iaoeaieo oeaio??a
? ee?oeiii? u?eueiino? a ieo (oaae. 3). I?e oeueiio ee?oeiia u?euei?noue
iaio?eieo ? ia?a?iaeueieo cii caeeoa?oueny ia eiio?ieueiiio ??ai?.
A?aecia/a?oueny iiyaa aaaaoi/enaeueiio ieaciioeeo?a c Ig I ? ae?aaeaiith
ooieoe?iiaeueiith iai?oaeai?noth aioo??oiueiee?oeiieo i?aaiae.
Ca?eueoaiiy ?ici???a e?ioi?aeieo aoceee?a iia’ycaia, i/aaeaeii, ia
o?eueee c i?a?aoe??th A-e?ioioeeo?a ?c e?noeiaiai iiceo, aea e c
i?ie?oa?aoe??th «naneeueieo» A-e?ioioeeo?a, ui oa?aeoa?ia aeey ooai?aiiy
na?oeeo oeaio??a (I.I.Butter, 1997). O ia?ea?oa??aeuei?e cii? ca?eueoaia
e?euee?noue iac??eeo Thy-1 O-e?ioioeeo?a.

AENIIAEE

1. No?oeoo?ii-ooieoe?iiaeueieie iniaeeainoyie oeiona uo??a i?ney ae??
a?noeiaoo a aeic? 0,5 a/ea ? ia?aaaaeaiiy i?ioean?a i?ie?oa?aoe??
ai?oae?i?aoeeoeioeeo?a iaae e?ioioeeoiiiacii ia oii? i?aeaeuaiii?
ooieoe?iiaeueii? aeoeaiino? ai?oae?i?aoeeoey?ieo ee?oei; iiyaa c??eeo
A-e?ioioeeo?a a ia?eaaneoey?ieo ii?iaeieiao. O e?noeiaiio iiceo
a?aei?/aii cieaeaiiy u?eueiino? ee?oeiieo aeaiaio?a.

2. Ae?y a?noeiaoo a naeac?ioe? i?iyaey?oueny o a?ia?ieac?? A-caeaaeieo
cii, aenieei nooiaiai ?ioiieia?/ii? c??eino? O- ? A-e?ioioeeo?a ia oii?
i?aeneeaiiy iae?ioaa?/ii? ?aaeoe??, ui i?aeoaa?aeaeo?oueny a?aeiinii
aenieei ??aiai i?iaeoeoe?? ?ioiiaeiaoe?i?a.

3. No?oeoo?ii-ooieoe?iiaeuei? iniaeeaino? oeiona uo??a i?ney ae??
?iaeiiaoaoeeio o aeic? 1 ia/ea i?iyaeythoueny o aa?iii?eiiio iineeaii?
e?ioioeeoiiiaco, i?ie?oa?aoe?? ai?oae?i?aoeeoeioeeo?a ? ?o aenie?e
ooieoe?iiaeuei?e aeoeaiino?. O e?noeiaiio iiceo aeyaey?oueny iineeaiiy
i??eioeeoiiiaco.

4. A naeac?ioe? ae?y ?iaeiiaoaoeeio aeeeeea? a?ia?ieac?th ye
O-caeaaeieo, oae ? A-caeaaeieo cii c cao?eieith aeic??aaiiy
A-iiioeyoe??, ui i?ecaiaeeoue aei iiyae iac??eeo A-e?ioioeeo?a ?
aeeni?iaeoeoe?? ?ioiiaeiaoe?i?a (cieaeaiiy i?iaeoeoe??
?ioiiaeiaoe?ia G).

5. No?oeoo?ii-ooieoe?iiaeuei? iniaeeaino? oeiona uo??a i?ney ae??
eaaai?cieo a?ae?ioei?eaeo o aeic? 30 ia/ea i?iyaeythoueny ia?aaaaeaiiyi
e?ioioeeoiiiaco iaae i?ioeanaie i?ie?oa?aoe?? ai?oae?i?aoeeoeioeeo?a ia
oii? cao?eiee aiiioica ei?oeeaeueieo oeiioeeo?a ? cieaeaiiy
ooieoe?iiaeueii? aeoeaiino? ai?oae?i?aoeeoeioeeo?a. A o e?noeiaiio
iiceo niinoa??aa?oueny i?aeaeuaiee i??eioeeoiiiac.

6. Ae?y eaaai?cieo o naeac?ioe? i?iyaey?oueny ii?ooaiiyi aeic??aaiiy
O-ee?oeiii? iiioeyoe??; a?ia?ieac??th aa?i?iaoeaieo oeaio??a;
i?aeaeuaiiyi ??aiy i?iaeoeoe?? ?ioiiaeiaoe?i?a (iniaeeai ?ioiiaeiaoe?ia
I).

I?aeoe/i? ?aeiiaiaeaoe??:

1. Aeey io?eiaiiy iiaii? ? ia’?eoeaii? ioe?iee noaio ?ioiieiiiaoaioieo
i?aai?a eaai?aoi?ieo oaa?ei iaiao?aeii aeei?enoiaoaaoe eiiieaen
ii?oiiao?e/ieo ? ?ioiiii?oieia?/ieo iaoiae?a aeey aea/aiiy ?aoeaioi?iiai
aia?aoo O- ? A-ee?oei ? anoaiiaeaiiy nooiaiy ?oiuei? c??eino?.

2. I?e canoinoaaii? a iaaee/i?e i?aeoeoe? a?noeiaoo ne?ae a?aoiaoaaoe
eiai caeaoi?noue noeioethaaoe ee?oeiiee ?ioi?oao, iae?ioaa?/io nenoaio
oa cieaeoaaoe ee?oeiio u?eueiinoue e?noeiaiai iiceo..

3. I?e i?ecia/aii? a iaaee/i?e i?aeoeoe? ne?ae a?aoiaoaaoe caeaoi?noue
?iaeiiaoaoeeio cieaeoaaoe i?iaeoeoe?th ee?oei-noi?ani??a; a eaaai?cieo
-noeioethaaoe aoii?aeueio eaieo ?ioi?oaoo.

Nienie iioae?eiaaieo i?aoeue ca oaiith aeena?oaoe??:

1. Aea?aa O.A., Ianeianueeee N.TH. Aca?iica’ycie ii?oiooieoe?iiaeueiiai
noaio oeiono, e?noeiaiai iiceo oa naeac?iee iaoethe?a i?e ae?? aenoeiaoo
// A?niee A?iieoeueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo. — 1999. —
O.3, N1. — N.19-20.

2. Aeaaaa O.A., Ni?ieeia E.A.Ii?oieiae/aneea eciaiaiey a oeiona e?un
iinea aicaeaenoaey oaaeaoie eiaeiiaoaoeeia e aenoeiaoa // A?niee
i?iaeai a?ieia?? ? iaaeeoeeie. — 1998. — Aei.4. — N.132-138.

3. Deeva T.V., Maslovsky S.U. Effect of Levamisol on morphological
changes in thymus, bone marrow and spleen of rats // A?niee ii?oieia??.
— 1999. — O.5, N1. — N.37-38.

4. Aeaaaa O.A., Naiieeia I.A. Ii?oiiao?e/aneay oa?aeoa?enoeea
eiiiiiaioia aeei/eiaie aeaeacu e?un i?e aicaeaenoaee iaeioi?uo
eaea?noaaiiuo aauanoa // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu. —
1996. — Aui.6. — N.68-72.

5. Aeaaaa O.A., Ianeianeee N.TH. Oeion, einoiee iica e naeacaiea e?un
iinea aeaenoaey aenoeiaoa // Yenia?eiaioaeueiay e eeeie/aneay
iaaeeoeeia. — 1998. — N1. — N.140-142.

6. Ae??aa O.A. Ii?oiooieoe?iiaeuei? iniaeeaino? oeiono uo??a i?ney
aieeao ?iaeiiaoaoeeio // E?ee. — 1997. – N 3. — N.79-81.

7. Aeaaaa O.A. Oeueo?ano?oeoo?iua iniaaiiinoe oeiona e?un a ii?ia //
Iaaeeoeeia naaiaeiy e caao?a — Oa?ueeia: OAIO. – 1997. — Aui.2. —
N.12-13.

8. Aeaaaa O.A. Aeeyiea eiaeiiaoaoeeia ia ninoiyiea i?aaiia eiioiiaaiaca
// Oac. iao/.-i?aeo. eiio. «Iao/iua aeinoeaeaiey e i?iaeaiu
i?iecaiaenoaa eaea?noaaiiuo n?aaenoa». — Oa?ueeia. — 1995. — N.184-185.

9. Ae??aa O.A. Aieea ?iaeiiaoaoeeio ia noai aeei/eiai? caeice uo??a //
Iao. ? Iaoe?iiaeueiiai c’?caeo oa?iaeieia?a Oe?a?ie «No/ani? i?iaeaie
oa?iaeieia??». — Ee?a-Iieoaaa, 1995. — N.54.

AIIOAOe?ss

Aea?aa O.A. Ii?oiooieoe?iiaeueiee noai oeiona, e?noeiaiai iiceo oa
naeac?iee uo??a i?ney aieeao ?ioiio?iiieo e?ea?nueeeo cania?a. ?oeiien

Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy eaiaeeaeeoa a?ieia?/ieo
iaoe, 14.03.01 — ii?iaeueia aiaoii?y. — Oa?iii?euenueea aea?aeaaia
iaaee/ia aeaaeai?y, Oa?iii?eue, 1999.

Aeine?aeaeaii ii?oieia?th oeiono, e?noeiaiai iiceo oa naeac?iee uo??a,
?ioiieia?/ieo aeanoeainoae O- ? A-e?ioioeeo?a i?ney aieeao a?noeiaoo,
?iaeiiaoaoeeio, eaaai?cieo a?ae?ioei?eaeo. A?noeiao aeeeeea? iineeaio
i?a?aoe?th A-e?ioioeeo?a c e?noeiaiai iiceo, ui ei?aeth? c iiyaith
A-e?ioioeeo?a a ia?eaaneoey?ieo ii?iaeieiao oeiono, ?icoe?aiiyi
e?ioi?aeieo aoceee?a naeac?iee, ca?eueoaiiyi o i?e e?eueeino?
ieaciioeeo?a c Ig M, G, A, N-3 o?aeoe?? eiiieaiaioo. A oeion?
aeoea?co?oueny ai?oae?i?aoeeoeiiiac, ui ni?ey? aec??aaiith
O-e?ioioeeo?a. ?iaeiiaoaoeei iineeth? e?ioioeeoiiiac a oeion?,
i?eaiaeeoue aei aeoeaiiai noaio ai?oae?i?aoeeoeioeeoe, ui noai?th?
ia?aaeoiiae aeey ?ioiieia?/ii? c??eino? O-e?ioioeeo?a. I?aeaeuo?
i?ie?oa?aoe?th A-e?ioioeeo?a o e?noeiaiio iiceo ? ii?ooo? ?o aec??aaiiy.
Oea i?ecaiaeeoue aei ciaioaiiy iiioeyoe?? ieaciioeeo?a, ui i?iaeoeothoue
Ig G. A naeac?ioe? a?ia?ieaciaaia a?ea ioeueia ia oii? cieaeaiiy
iae?ioaa?/ii? ?aaeoe??. Eaaai?cie i?aeaeuo? i?ie?oa?aoe?th ye O-, oae ?
A-e?ioioeeo?a, cao?eio? aiiioic, cieaeo? aeoeai?noue
ai?oae?i?aoeeoeioeeo?a oeiona, ui ii?ooo? aec??aaiiy O-e?ioioeeo?a. A
naeac?ie? eaaai?cie i?aeneeth? ieaciaoecaoe?th.

Eeth/ia? neiaa: oeion, e?noeiaee iicie, naeac?iea, e?ioioeeo,
ai?oae?i?aoeeoeioeeo, a?noeiao, ?iaeiiaoaoeei, eaaai?ciea a?ae?ioei?eae.

Aiiioaoeey

Aeaaaa O.A. Ii?oiooieoeeiiaeueiia ninoiyiea oeiona, einoiiai iicaa e
naeacaiee e?un iinea aeaenoaey eiioiio?iiiuo eaea?noaaiiuo n?aaenoa.
?oeiienue.

Aeenna?oaoeey ia nieneaiea o/aiie noaiaie eaiaeeaeaoa aeieiae/aneeo
iaoe, 14.03.01 – ii?iaeueiay aiaoiiey. – Oa?iiiieueneay ainoaea?noaaiiay
iaaeeoeeineay aeaaeaiey ei. E. Ai?aa/aaneiai, Oa?iiiieue, 1999.

Enneaaeiaaia ii?oieiaey oeiona, einoiiai iicaa e naeacaiee naioeia e?un,
eiioiieiae/aneea iniaaiiinoe O- e A-eeioioeeoia iinea aeaenoaey
aenoeiaoa, eiaeiiaoaoeeia e eaaaieciea aeae?ioei?eaea. I?aia?aou
aaiaeeeenue a oa/aiea ianyoea a aeicao: aenoeiao — 0,5 a/ea,
eiaeiiaoaoeei – 1,0 ia/ea, eaaaiecie – 30 ia/ea.

Oeion e naeacaiea acaaoeaaeenue, ii?aaeaeyeenue eo ?acia?u. Iinea
oeenaoeee e ia?aaioee ii iauai?eiyoui iaoiaeeeai iieo/aee
aenoieiae/aneea n?acu oieueiie 4-6 iei. N?acu ie?aoeaaee aaiaoieneeeiii
e yiceiii, ii A?aoa, aeey auyaeaiey iae?ioaaia noaaeee OEE-?aaeoeeth.
Aeeooa?aioee?iaaiiia eco/aiea O- e A-eeioioeeoia i?iaiaeeee i?yiui e
iai?yiui iaoiaeaie Eoina ia ia?aoeiiauo n?acao. Oeueo?ano?oeoo?iay
oa?aeoa?enoeea eeaoie iieo/aia i?e eniieueciaaiee iaoiaea
oeueo?ano?oeoo?iie iee?ineiiee. Ii?oiiao?ey no?oeoo?iuo eiiiiiaioia
i?aaiia i?iaaaeaia n iiiiuueth i?eai?a “Eioaa?ae 2I”.

Auyaeaii, /oi aenoeiao aucuaaao oneeaiioth iea?aoeeth c?aeuo CD 22
A-eeioioeeoia ec einoiiai iicaa, /oi ei??aee?oao n iiyaeaieai
A-eeioioeeoia a ia?eaaneoey?iuo i?ino?ainoaao oeiona, oaaee/aieai
ieiuaaeae eeioieaeiuo ocaeeia naeacaiee, oaaee/aieai a iae eiee/anoaa
ieaciioeeoia n eiioiiaeiaoeeiaie M, G, A, C-3 o?aeoeee eiiieaiaioa. A
oeiona aeoeaece?oaony yieoaeei?aoeeoeiiiyc, /oi niinianoaoao nic?aaaieth
e aeeooa?aioee?iaea O-eeioioeeoia.

Eiaeiiaoaoeei oneeeaaao i?ioeannu eeioioeeoiiiyca a oeiona, /oi
nii?iaiaeaeaaony ?anoe?aieai noaeainoey?iie ciiu, i?eaiaeeo a aeoeaiia
ninoiyiea yieoaeei?aoeeoeioeeou, yoi nicaeaao oneiaey aeey
eiioiieiae/aneiai nic?aaaiey O-eeioioeeoia. I?aia?ao oneeeaaao
i?ieeoa?aoeeth A-eeioioeeoia a einoiii iicaa, ii i?e yoii ia?ooathony
i?ioeannu eo nic?aaaiey. Yoi i?eaiaeeo e iiyaeaieth iac?aeuo
i?a-A-eeioioeeoia ia ia?eoa?ee e noaeaieth iiioeyoeee ieaciioeeoia,
iniaaiii i?iaeooee?othueo eiioiiaeiaoeei G. A naeacaiea aeia?ieace?iaaia
aaeay ioeueia ia oiia nieaeaiey iae?ioaaaeueiie ?aaeoeee.

I?e aeaenoaee eaaaieciea aeae?ioei?eaea iiauoaaony i?ieeoa?aoeey
eeioioeeoia eae a oeiona, oae e a einoiii iicaa, caaea?aeeaaaony
aiiioic e nieaeaaony aeoeaiinoue yieoaeei?aoeeoeioeeoia a oeiona, /oi
i?eaiaeeo e ia?ooaieth i?ioeannia nic?aaaiey O-eeioioeeoia. A naeacaiea
a oeioncaaeneiuo ciiao oaaee/eaaaony eiee/anoai iac?aeuo Thy-1
O-eeioioeeoia. ?aaeoeey ieaciaoecaoeee oneeeaaaony eae can/ao iea?aoeee
c?aeuo A-eeioioeeoia ec einoiiai iicaa, oae e can/ao i?ieeoa?aoeee
“nanneeueiuo” eeioioeeoia.

Eeth/aaua neiaa: oeion, einoiue iica, naeacaiea, eeioioeeo,
yieoaeei?aoeeoeioeeo, aenoeiao, eiaeiiaoaoeei, eaaaieciea aeae?ioei?eae.

SUMMARY

Tatyana V. Deeva. Morphological and functional state of thymus, bone
marrow and spleen of rats after the application of immunothropos
remrdies. Manuscript.

Dissertation for the reach of scientific degree of the candidate of
biological sciences, 14.03.01 – Normal Anatomy. – Ternopil State
Medical Academy after I. Gorbachevsky, Ternopil, 1999.

Research of thymus, bone marrow and spleen morphology of rats,
immunological properties of T- and B-lymphocytes in condicions of
hystinate, indomethacine, levamisole hydrochloride interference.
Hystinate caused of B-lymphocytes intensive migration in bone marrow;
the latter has been correlated with the appear of B-lymphocytes in
perivascular areas of thymus, enlargement of spleen lymphoid junctions,
increasing of the number of plasmocytes with Ig M, G, A, C-3 fraction of
the complement. Epythelioreticulopoes has been activated in thymus; the
latter promotes the maturity of T-lymphocytes . Indomethacine increases
the intensivity of lymphocytopoesis in thymus, drives the
epythelioreticular component in active position, that creates the
conditions for immunological maturity of T-lymphocytes. Indomethacine
increases the prolipheration of B-lymphocytes in bone marrow and
violates there maturation, that causes the decrease of plasmocytes, that
produce Ig G. Indomethacine causes hyperplasia of white pulp at the
bacground of macrophagous reaction in spleen. Levamisole causes the
prolipheration tension of both T- and B-lymphocytes, apopthose
relaxation, decrease of secretion activity of epythelioreticulocytes in
thymus, which violates the maruration of T-lymphocytes. Hyperplasia of
B-areas has been indicated at the background of plasmotion increasing.

The key words: thymus, bone marrow, spleen, lymphocyte,
epytelioreticulocyte, hystinate, indomethacine, levamisole hydrochlorid.

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