Мінеральний та імунний дисбаланс при дигестивній патології в умовах екологічного пресингу і спосіб корекції: Автореф. дис… д-ра мед. наук / Л.В. Шка

I?I?NOA?NOAI IOI?IIE CAeI?IA’ss OE?A?IE

EE?ANUeEA IAAeE*IA AEAAeAI?ss

I?NEssAeEIEIIII? INA?OE ?I. I. E. Ooieea

Oeaea Ethaia Aieiaeeie??aia

OAeE 616.33-342-002-008.9:612.017.1:57.042

I?IA?AEUeIEE OA ?IOIIEE AeENAAEAIN

I?E AeEAANOEAI?E IAOIEIA?? A OIIAAO AEIEIA?*IIAI I?ANEIAO ? NIIN?A
EI?AEOe??

14. 01. 02 — aioo??oi? oai?iae

Aaoi?aoa?ao aeena?oaoe??

ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

EE?A — 1999

Aeena?oaoe??th ? ?oeiien.

?iaioa aeeiiaia a Eoaainueeiio aea?aeaaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie.

Iaoeiaee eiinoeueoaio aeieoi? iaaee/ieo iaoe, i?ioani?

Aeia??i Ai?en THe?eiae/

Eoaainueeee aea?aeaaiee iaaee/iee

oi?aa?neoao IIC Oe?a?ie, eaoaae?a

aini?oaeueii? oa?ai?? ? 1,
i?ioani? eaoaae?e

Io?oe?ei? iiiiaioe: aeieoi? iaaee/ieo iaoe, i?ioani?

Eenaiei A?eai??e ?aaiiae/

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii?

ina?oe ?i. I.E.Ooieea IIC Oe?a?ie,

caa?aeoaa/ eaoaae?e n?iaeii?
iaaeeoeeie,

ee?i?/ii? ?ioiieia?? oa aea?aieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

A?eoeaiei ?aai ?aaiiae/

Aei?i?iiao?ianueea aea?aeaaia iaaee/ia
aeaaeai?y

IIC Oe?a?ie, caa?aeoaa/ eaoaae?e

aano?iaioa?ieia?? ? oa?ai?? oaeoeueoaoo

i?neyaeeieiiii? ina?oe

aeieoi? iaaee/ieo iaoe, i?ioani?

Ei?coi A?oae?e Iaoiiae/

Iaoeiaee oeaio? ?aae?aoe?eii?
iaaeeoeeie

AII Oe?a?ie, caa?aeoaa/ eaai?aoi???

?aae?aoe?eii? a?a??ie oa?/oaaiiy

I?ia?aeia onoaiiaa Iaoe?iiaeueiee iaaee/iee oi?aa?neoao

?i. I.I.Aiaiiieueoey IIC Oe?a?ie,
eaoaae?a

aini?oaeueii? oa?ai?? ?2 (i.Ee?a)

Caoeno a?aeaoaeaoueny “_27_”_aeiaoiy_1999 ?. i 11_ aiaeei? ia
can?aeaii? niaoe?ae?ciaaii? a/aii? ?aaee Ae 26.613.01 i?e Ee?anuee?e
iaaee/i?e aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie
(01112, i. Ee?a, aoe. Aei?iaiaeeoeueea, 9, aoae. ? 3).

C aeena?oaoe??th iiaeia iciaeiieoenue o a?ae?ioaoe? Ee?anueei? iaaee/ii?
aeaaeai?? i?neyaeeieiiii? ina?oe ?i. I.E.Ooieea IIC Oe?a?ie (01112,
i. Ee?a, aoe. Aei?iaiaeeoeueea, 9).

Aaoi?aoa?ao ?ic?neaiee “_25_”__aa?aniy___1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

e.i.i., aeioeaio
I.?. ?iiaiaiei

CAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. I?iaeaia aeieia?/iiai i?aneiao a no/anieo oiiaao
iaaoea nioe?aeueiiai cia/aiiy. I?e/eiith oiai ? aeniea iioe?ai?noue
caoai?thaaiue na?aae e?ea?aeaoi??a iane?aee?a aaa??? (EIA) ia *AAN, ye?
caciaee eiia?iiaaii? ae?? aa?aneaieo /eiiee?a, cie?aia ?aae?aoe?eiiai
(Caa?eiaa A.N., Oaaei?ianueea I.I., Iaca?/oe E.A., 1994; Caoa?ao I.I.,
?aaiiaa I.A., E?aa/aiei I.I., 1995; Aioeiiaa N.?., Ei?aeoeia A.I.,
?ic?ia I.A., 1996), oa na?aae ?ia?oiee?a i?iieneiaeo i?aei?e?inoa,
aeiaai/anii eiioaeooth/eo ?c o?i?/ieie oaeoi?aie, cie?aia aaaeeeie
iaoaeaie (Eoeaa?ia A.I., 1996; Oiainueeee A.ss., ?aaieoeueea I.O.,
Na?aa?aa E.I., 1997).

Eoaainueea iaeanoue oa?aeoa?eco?oueny ye aeieia?/ii iaaeaaiiieo/ia, ui
a?aeaeaa?oueny ia noai? caei?ia’y ianaeaiiy.

Oae, ??aaiue caaaeueii? caoai?thaaiino? EIA a Eoaainuee?e iaeano? a 1,9
?aca ia?aaeuo? ??aaiue na?aae onueiai ianaeaiiy iaeano?. I?e oeueiio
ieoiia aaaa iaoieia?? i?aai?a o?aaeaiiy caeiyea i?ia?aeia i?noea a
no?oeoo?? caaaeueii? caoai?thaaiino? na?aae EIA.

O 1,2 ?aca caoai?thaai?noue na?aae ?ia?oiee?a aeoioeyoi?iiai
ae?iaieoeoaa ia?aaeuo? caaaeueio caoai?thaai?noue na?aae ianaeaiiy
Eoaainueei? iaeano?. Aiaeia?/ii “e?aee?o?” aano?iaeoiaeaiaeueia
iaoieia?y o ?ia?oiee?a ae?iaieoeoaa eoaeieo aeoioeyoi??a.

Iaaeiaaeeiai iaoieia?th i?aai?a o?aaeaiiy a?aeiinyoue aei aeieia?/ii
caeaaeii? (Ia?? E.A., Aea?ea/ia A.I., Ooaia I.I., 1997).

Iaeieie c ?aii?o oa /ooeeaeo iieaciee?a iani?eyoeeaiai aieeao ia
i?aai?ci /eiiee?a iaaeieeoiueiai na?aaeiaeua ?, cie?aia, i?ia?aeueiee oa
?ioiiee noaoon. Aeaci?aai?caoe?y i?ia?aeueiiai oa ?ioiiiai aaeaino iiaea
noeeyoe aei i?aaiiiaoieia?? (*ei/aae/ A.?., ?oaeaanueea I.?., 1997).

Aeyaeai? ci?ie a i?ia?aeueiiio aiiainoac? i?ae /an ae?? ?ii?coth/iai
aei?ii?ithaaiiy (Oooi/e?ia E.O., Ieiioeaaa I.?., Oa?aeaiiaa I.O., 1990;
Ooo?yinueeee A.A., Oeeaaiaiei I.ss., Iaaeaiei I.A., 1990; ?aaieoeueea
I.O., 1994) oa enaiia?ioee?a (Ca?a?ii Ae.Ae., Oa?auaiei A.I., Aeooea
?.ss., 1996).

E??i oiai, ?niothoue a?aeiiino? i?i ?ioii? c?ooaiiy i?e ae?? ?aae?aoe??
(Naoii O.I., *oiae I.I., 1992; Aaceea Ae.I., *oiae I.I., 1992;
Iaeueieeia I.O., Naiao? I.A., 1994) oa i?iieneiaiai oaeoi?o (Oienoay
I.A., Ai?/aeia I.I., Inoaiaiei A.I., 1990; Eoea- eia I.A., Eoeaeia
A.A., Neiiiiaa A.A., 1993; Eiaaoi?eia A.A., Aiae TH.I., O?ieia A.I.,
1997).

Oyaee?noue ia?aa?ao aano?iaeoiaeaiaeueieo caoai?thaaiue, iayai?noue
/anoeo caaino?aiue o in?a, ui ia?aaoaathoue a oiiaao aeieia?/iiai
i?aneiao, a oaeiae a?aenooi?noue iaeaaeiiai aoaeoo a?ae o?aaeeoe?eiiai
e?eoaaiiy coiiaeththoue iaiao?aei?noue aea/aiiy aieeao ?aae?aoe?eiiai oa
i?iieneiaiai /eiiee?a ia iaoieia?th i?aai?a o?aaeaiiy oa ?ic?iaee
iiaeo cania?a iaoiaaiaoe/ii? ei?aeoe??.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Aeena?oaoe?eia
?iaioa aeeiiaia a?aeiia?aeii aei ieaio iaoeiai-aeine?aeieoeueeeo ?ia?o
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo oa yaey? niaith
o?aaiaio i?ia?aie Eaa?iaoo I?i?no??a Oe?a?ie “?ic?iaea nenoaie
?ioiieia?/iiai iii?oi?eiao oa ?ioii?aaa?e?oaoe?? ?ia?oiee?a iniiaieo
aaeocae aaeeeiai i?iieneiaiai ae?iaieoeoaa ? a?oi ?eceeo ianaeaiiy
i?iieneiai? ciie Aeiiaano” (? aea?aeaaii? ?a?no?aoe?? 019000242).

Iaoa aeine?aeaeaiiy: aea/eoe ee?i?/i? i?iyae aano?iaeoiaeaiaeueii?
iaoieia?? a oiiaao aeieia?/iiai i?aneiao, o/anoue ?ioiieo oaeoi??a oa
ii?ooaiue i?ia?aeueiiai aaeaino e?ia? a iaoiaaiaoe/ieo iaoai?ciao, ui
aecia/athoue aa?aneai?noue ia?aa?ao, oa ?ic?iaeoe niiniae ?o ei?aeoe??.

Caaea/? aeine?aeaeaiiy:

1. I?iaiae?coaaoe ?acoeueoaoe aaaaoi??/iiai iii?oi?eiao o oai?eo ?c
iaoieia??th i?aai?a o?aaeaiiy a oiiaao ia?aaoaaiiy a aa?aneaiiio
i?e?iee?iao? oa c ?aae?aoe?eiith ae??th.

2. Ioe?ieoe ee?i?ei-eaai?aoi?i? oa ?ino?oiaioaeuei? aeai? aeine?aeaeaiue
oa aecia/eoe iniaeeaino? ee?i?/ieo i?iya?a aano?iaeoiaeaiaeueii?
iaoieia??.

3. Iaoiaeii aia?ai-aeenia?n?eiiai ?aioaai?anueeiai aiae?co aeine?aeeoe
o?ce/io aeoeai?noue i?ia?aeueieo ?a/iaei e?ia? oa ioe?ieoe i?ia?aeueiee
aaeain.

4. I?iaiae?coaaoe i?ia?aeueiee aaeain e?ia? c o?aooaaiiyi ci?i ia oii?
ciai?oiuei? ?aae?aoe?eii? ae?? oa i?iieneiaiai /eiieea.

5. Aea/eoe ?ioiiee aiiainoac oa aeyaeoe ii?ooaiiy eiai a oiiaao
aeieia?/iiai i?aneiao.

6. C?noaaeoe ?acoeueoaoe aeine?aeaeaiue ?ioi?oaoo oa o?ce/ii? aeoeaiino?
i?ia?ae?a ?c iniaeeainoyie ia?aa?ao aano?iaeoiaeaiaeueii? iaoieia?? a
oiiaao ae?? aeieia?/ii iani?eyoeeaeo oaeoi??a ? aecia/eoe iayai?noue
caeaaeiino? i?ae ieie.

7. ?ic?iaeoe oa aeei?enoaoe iiaee niin?a ei?aeoe?? i?ia?aeueiiai oa
?ioiiiai aeenaaeaino a in?a ?c iaoieia??th oeoieiai-eeoeiaiai o?aeoo a
oiiaao aeieia?/iiai i?aneiao.

8. Ioe?ieoe ii?ooaiiy i?ia?aeueiiai oa ?ioiiiai noaoono i?e ae??
eieaeueiiai ii?ii?ithaaiiy a iaiaaeaiiai eiioeiaaioo oai?eo.

9. Ai?iaoaaoe ?ic?iaeaiee niin?a ei?aeoe?? o oai?eo ?c neiae?iiii
i?iiaiaaeo ?aaeoe?e i?ae /an eieaeueiiai ii?ii?ithaaiiy.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aecia/ai? iniaeeaino?
ee?i?/ieo i?iya?a aano?iaeoiaeaiaeueii? iaoieia?? i?ae aieeaii
?ii?coth/i? ?aae?aoe?? oa i?iieneiaiai /eiieea.

?ice?eo? iia? iaoai?cie iaoiaaiaco iaoieia?? oeoieiai-eeoeiaiai o?aeoo a
oiiaao aa?aneaiiai na?aaeiaeua, cie?aia ei?aeyoe?eiee aca?iica’ycie
ii?ooaiue aiiainoaco oa ci?i o?ce/ii? aeoeaiino? iae?i- ? i?e?iaeaiaio?a
e?ia?.

Aeei?enoaiiy ?ai?oa ia aaeeaaiiai a iaaeeoeei? aia?ai-aeenia?n?eiiai
?aioaai?anueeiai aiae?co ia ?ano?iaiio aeaeo?iiiiio i?e?ineii? ?AI-101 c
aia?ai-aeenia?n?eiei ?aioaai?anueeei aiae?caoi?ii (AAeA?) aeicaieeei
aeaoe aeeaieo oa?aeoa?enoeeo noaio o?ce/ii? aeoeaiino? i?ia?aeueieo
?a/iaei e?ia?.

Aia?oa niinoa??aaeeny ? ?a?no?oaaeeny i?ee o?ce/ii? aeoeaiino? iae?i- oa
i?e?iaeaiaio?a e?ia? a oe?ieiio niaeo?? a?ae iao??th (11) aei ?o??th
(32) o oai?eo ?c iaoieia??th i?aai?a o?aaeaiiy, ye? ia?aaoaaee a
aeieia?/ii iani?eyoeeaeo oiiaao, ? o oai?eo, ye? io?eioaaee i?iiaiaao
oa?ai?th.

?ic?iaeaii iiaee niin?a ei?aeoe?? i?ia?aeueiiai oa ?ioiiiai aeenaaeaino,
ai?iaaoe?y yeiai i?eaaea aei iiceoeaii? aeeiai?ee ia?aa?ao iaoieia?/iiai
i?ioeano ia oii? ii?iae?caoe?? o?ce/ii? aeoeaiino? i?ia?aeueieo ?a/iaei
e?ia?, a oaeiae ee?oeiiiai e aoii?aeueiiai ?ioi?oaoo.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. Cai?iiiiiaaia iiaa
iiaeeea?noue aea/aiiy i?ia?aeueiiai aaeaino ca aeiiiiiaith AAeA? oa
?ioiiiai noaoono aeey ioe?iee aieeao aa?aneaiino? ciai?oiueiai
na?aaeiaeua.

Iaoiaaiaoe/ii iaa?oioiaaii canoinoaaiiy ?ic?iaeaiiai niiniao ei?aeoe?? a
in?a ?c a?iceaii-ae?aceiaeie o?aaeaiiyie aano?iaeoiaeaiaeueii? ciie, ui
caciaee ciai?oiueiai ii?ii?iaiiy, ? eiioaeooth/eo ?c aaaeeeie iaoaeaie,
aeey ii?iae?caoe?? o?ce/ii? aeoeaiino? i?ia?aeueieo ?a/iaei e?ia? oa
onoiaiiy iaoaaie?/ii? ?ioiiaeai?an??.

Iioae?eiaaii ?ioi?iaoe?eiiai eenoa “Canoinoaaiiy eiiieaeniio iaoae?a —
o?eeiio A o eiiieaeniiio e?eoaaii? aano?iaeoiaeaiaeueieo ae?acie o EIA
ia *AAN” (Oe?iaaeiaoaio?ioi?i IIC Oe?a?ie. — 1998 — Aei. 17, ? 40).

?ic?iaeaii niin?a ei?aeoe?? neiae?iio i?iiaiaaeo ?aaeoe?e (Iao. 17418
A Oe?a?ia, IE? A 61 E 31/00, A 61 N 5/10. Cayae. 18.12.95; Iioae.
31.10.97. Athe. ? 5).

?acoeueoaoe aeine?aeaeaiue ai?iaaaeaeaii a ?iaioo aano?iaioa?ieia?/iiai
a?aeae?eaiiy iaeanii? ee?i?/ii? e?ea?i? i. Eoaainueea, iie?ee?i?ee ? 11
i. Eoaainueea, cae?aaioieoo AIAI “Eoaainuee? aeoioeyoi?e”,
aano?iaioa?ieia?/iiai a?aeae?eaiiy iaeanii? ee?i?/ii? e?ea?i? i.
Aei?i?iiao?ianueea, o a?aeae?eaiiyo ?aae?ieia?? ? 1, 2 iaeaniiai
iieieia?/iiai aeeniaina?o i. Eoaainueea, o a?aeae?eaii? ?aae?i?cioiiii?
oa?ai?? i?nueeiai iieieia?/iiai oeaio?o i. Ee?aa, ?aae?ieia?/iiio
a?aeae?eaii? iaeanii? ee?i?/ii? e?ea?i? i. Ee?aa. Aeai?, iaea?aeai? a
aeena?oaoe??, aeeeaaeathoueny a eaeoe?eiiio eo?n? e ia i?aeoe/ieo
caiyooyo eaoaae?e n?iaeii? iaaeeoeeie ? iie?ee?i?/ii? oa?ai??, a oaeiae
caaaeueii? a?a??ie c aeieia??th Eoaainueeiai aea?aeaaiiai iaaee/iiai
oi?aa?neoaoo, i?i ui na?ae/aoue aeoe ai?iaaaeaeaiiy.

Iniaenoee aianie caeiaoaa/a. Aaoi?ii iniaenoi cae?eniaii naie??/iee
iii?oi?eia 415 oai?eo ?c aecia/aiiyi iniaeeainoae ee?i?/ieo i?iya?a
aano?iaeoiaeaiaeueii? iaoieia?? oa ee?i?/ieo i?iya?a neiae?iio
i?iiaiaaeo ?aaeoe?e.

Aaeaioiaaii oa aeei?enoaii aia?ai-aeenia?n?eiee ?aioaai?anueeee aiae?c
aeey aeine?aeaeaiiy o?ce/ii? aeoeaiino? i?ia?ae?a oe?eueii? e?ia?. Aaoi?
iniaenoi i?eeiaea o/anoue o aeine?aeaeaii? iae?i- oa i?e?iaeaiaio?a
e?ia?.

?ic?iaeaii niin?a ei?aeoe?? i?ia?aeueiiai oa ?ioiiiai aeenaaeaino i?e
a?iceaii-ae?aceiaeo o?aaeaiiyo oeoiea ? AeIE a oiiaao aeieia?/iiai
i?aneiao oa ioe?iaii eiai aoaeoeai?noue.

I?aeaioiaeaii oa iioae?eiaaii ?ioi?iaoe?eiiai eenoa “Canoinoaaiiy
eiiieaeniio iaoae?a — o?eeiio A o eiiieaeniiio e?eoaaii?
aano?iaeoiaeaiaeueieo ae?acie o EIA ia *AAN”.

?ic?iaeaii niin?a ei?aeoe?? neiae?iio i?iiaiaaeo ?aaeoe?e, eiai aeciaii
aeiaoiaeii, iaea?aeaii iaoaio. Aaoi? iniaenoi i?iaaea aiae?c ?
noaoenoe/io ia?iaeo io?eiaieo ?acoeueoao?a aeine?aeaeaiue, noi?ioethaaea
iniiai? aeniiaee, ye? aeianai? ia caoeno.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iniiai? iieiaeaiiy ?iaioe
aeeeaaeai? e iaaiai?ai? ia tha?eaei?e iaoeiai-i?aeoe/i?e eiioa?aioe??,
i?enay/ai?e 100-??//th 4-? i?nueei? e?ea?i? i. Eoaainueea (Eoaainuee,
1995); 6 eiia?an? i?aeia?iaeii? oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo
oiaa?enoa (Iaeana, 1996); 5 Anaoe?a?inuee?e ia?aae? c ieoaiue
iie?ee?i?/ii? ?iaioe (Aei?i?iiao?ianuee, 1996); tha?eaei?e
iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e 75-??//th eaoaae?e a?a??ie
oa aeieia?? ethaeeie Aei?i?iiao?ianueei? aea?aeaaii? iaaee/ii? aeaaeai??
(Aei?i?iiao?ianuee, 1997); iaoeiai-i?aeoe/i?e eiioa?aioe??, i?enay/ai?e
20-??//th eaoaae?e aano?iaioa?ieia?? Aei?i?iiao?ianueei? aea?aeaaii?
iaaee/ii? aeaaeai?? (Aei?i?iiao?ianuee, 1999).

Ioae?eaoe??. Ca oaiith aeena?oaoe?? iioae?eiaai? 33 iaoeia? ?iaioe,
aeeth/ath/e 16 noaoae o iaoeiaeo aeo?iaeao, c ieo naiino?eii — 15; 9
noaoae — o ca??ieeao iaoeiaeo i?aoeue, c ieo naiino?eii — 7; 7 — a
iaoa??aeao ? oacao eiioa?aioe?e, c ieo naiino?eii — 5; 1 iaoaio ia
aeiao?ae — naiino?eii.

Ianya ? no?oeoo?a aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 343 noi??ieao
ae?oeiaaiiai oaenoo e neeaaea?oueny c anooio, iaeyaeo e?oa?aoo?e, 3
?icae?e?a aeanieo aeine?aeaeaiue, caeeth/aiiy, aeniiae?a. Nienie
aeei?enoaieo e?oa?aoo?ieo aeaea?ae i?noeoue 332 a?o/eciyieo ? 187
caei?aeiiieo. ?iaioo ?ethno?iaaii 66 oaaeeoeyie ? 18 iaethieaie, ianya
yeeo noaiiaeoue 35 noi??iie aeena?oaoe??.

CI?NO ?IAIOE

Iaoa??aee ? iaoiaee aeine?aeaeaiiy. Ia’?eoii aeine?aeaeaiiy aoee 415
oai?eo i?ioyaii 7 ?ie?a. 1-o a?oio neeaee 137 EIA ia *AAN ?c
aano?iaeoiaeaiaeueieie caoai?thaaiiyie, on? /ieia?ee o a?oe? a?ae 27 aei
60 ?ie?a. Na?aae ieo 11 (8,0%) oai?eo a?eii aei 30 ?ie?a; 73 (53,3%) —
a?eii a?ae 31 aei 40 ?ie?a; 44 (32,1%) — a?eii a?ae 41 aei 50 ?ie?a; 9
(6,6%) — a?eii a?ae 51 aei 60 ?ie?a.

Aei o/ano? o ?aiiioii-aoae?aaeueieo ?iaioao ia *AAN on? /ieia?ee i?ieoee
iaaee/iee iaeyae, ca?aeii c yeei aoee aeciai? i?aeoe/ii caei?iaeie. EIA
aeeiioaaee ia *AAN oae? ?iaioe: ?iaioa ia aeaoo 3-ai oa 4-ai
aia?aiaeie?a — 32 (23,6%); aoae?aaeuei? ?iaioe — 8 (5,8%);
aeacaeoeaaoe?y i?ei?uaiue, iaeyao, o?ainii?oo — 29 (21,4%); iioiaaiiy
?aae?iaeoeaieo ?a/iaei, iaioiaee?oaaiiy, caieyiiai a?oioo — 28 (20,5%);
ia?aaacaiiy ?ia?oiee?a oa ?io? ?iaioe — 39 (28,7%).

Ia EIA aoea ni?yiiaaia eiia?iiaaia ae?y ?yaeo /eiiee?a: iae?iaaiiee
no?an, ?ii?coth/a aei?ii?ithaaiiy, o?i?/i? oaeoi?e oa ?io?. Oa?i?i
ia?aaoaaiiy a cii? i?aeaeuaiiai ?aae?iaeoeaiiai caa?oaeiaiiy — c aa?aniy
1986 ?. ii a?oaeaiue 1990 ?. I?e oeueiio na?aaeiy o?eaae?noue neeaaeaea
67,5 aei?a. I?iiaiaaa iaaaioaaeaiiy EIA aoei a iaaeao “iaeiai” — a?ae
3,0 aei 25,0 nA? ca io?oe?eieie aeaieie c iaaee/ii? aeieoiaioaoe??.
A?eueo?noue EIA iaea ca’ycie aeieeiaiiy caoai?thaaiue ?c ia?aaoaaiiyi ia
?aiiioii-aoae?aaeueieo ?iaioao ia *AAN. Ca aeaieie i?i no?iee ?icaeoeo
iaoieia?? i?aai?a o?aaeaiiy i?ney o/ano? a ?iaioao ia *AAN, o 12 (8,8%)
EIA ee?i?/i? i?iyae caoai?thaaiiy c’yaeeeny i?ioyaii iaeiiai ?ieo, o 54
(39,4%) — /a?ac 1 — aei 3 ?ie?a, o 41 (29,9%) — /a?ac 3 — aei 5 ?ie?a, o
30 (21,9%) — i?ney 5 ?ie?a.

A oe?eiio, iioe?ai?noue iaoieia?? oeoieiai-eeoeiaiai o?ae-oo na?aae EIA
ia?aaeuoaaea iieacieee ianaeaiiy Eoaainueei? iaeano? a 3,9 ?aca.

2-o a?oio ii??aiyiiy neeaee 139 ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa c
aano?iaeoiaeaiaeueieie caoai?thaaiiyie a?eii a?ae 28 aei 60 ?ie?a.
Na?aae ieo 4 (2,9%) oai?eo — aei 30 ?ie?a; 13 (9,4%) — a?ae 31 aei 40
?ie?a; 74 (53,2%) — a?ae 41 aei 50 ?ie?a; 48 (34,5%) — a?ae 51 aei 60
?ie?a. C /enea ?ia?oiee?a 56 (40,3%) — /ieia?ee, 83 (59,7%) — ae?iee.
On? oai?? ca i?ioan??th ?iciiae?eyeeny oae: neeaaeaeueieee aeoioeyoi??a
— 29 (20,9%); aeaeo?iae/eee — 28 (20,1%); aaeueaai?ee — 5 (3,6%);
aei?iaoaa/?-oi?ioaaeueieee oa aia?aoieee — 5 (3,6%); aaci- oa
aeaeo?icaa?ieee — 15 (10,8%); iaey?e — 3 (2,2%); nethna??-iaeaae/eee —
21 (15,1%); eiio?iea?e oa eiiieaeooaaeueieee — 11 (7,9%); ?io? — 22
(15,8%).

I?ae /an ae?iaieoeoaa eoaeieo aeoioeyoi??a ?ia?oieee iathoue iino?eiee
eiioaeo ?c oaeoi?aie i?ioan?eii? oe?aeeeaino?, cie?aia ieeii a?ao?oo,
cae?ca, ieenii eaaei?th, i?eaeth, ia?aie ?ooo?, naeioeth, aiieneaeieie
niieaie oa ?ioeie o?i?/ieie ?a/iaeiaie. I?e oeueiio, iacaaaeath/e ia
aeei?enoaiiy ?ia?oieeaie ?iaeea?aeoaeueieo cania?a caoenoo, aiie
eiioaeoothoue ?c cacia/aieie niieo/aiiyie, eiioeaio?aoe?y yeeo ia?aaeuo?
aeiionoeio a 2,0 — 3,0 ?ace /a?ac caaaeueio caaaciaai?noue oeao?a,
iecueeee ??aaiue iaoai?caoe?? oa aaoiiaoecaoe?? ae?iaieoeoaa (75%).

Noaae ?iaioe a aeieia?/ii iani?eyoeeaiio aeoioeyoi?iiio ae?iaieoeoa? o
38 (27,3%) ?ia?oiee?a aoa a?ae 5 aei 10 ?ie?a; o 55 (39,6%) — a?ae 11
aei 15 ?ie?a; o 27 (19,4%) — a?ae 16 aei 20 ?ie?a; o 19 (13,7%) — iiiaae
20 ?ie?a.

A oe?eiio, iioe?ai?noue iaoieia?? i?aai?a o?aaeaiiy na?aae ?ia?oiee?a
aeoioeyoi?iiai ae?iaieoeoaa ia?aaeuoaaea iieacieee ianaeaiiy Eoaainueei?
iaeano? a 2,6 ?aca.

3-th a?oio ai?iaaoe?? aeey ioe?iee aoaeoeaiino? ?ic?iaeaiiai niiniao
ei?aeoe?? neeaee 139 oai?eo, ui caciaee eieaeueiiai ii?ii?iaiiy. On?
ae?iee c? ceiye?nieie iooeeiaie iiei/ii? caeice o a?oe? a?ae 31 aei 70
?ie?a. Na?aae ieo 9 (6,5%) oai?eo — aei 40 ?ie?a; 34 (24,5%) — a?ae 41
aei 50 ?ie?a; 50 (36,0%) — a?ae 51 aei 60 ?ie?a; 46 (33,0%) — a?ae 61
aei 70 ?ie?a. Ca i?ioan??th 30 (21,6%) ae?iie aoee caeiyo? o ae?iaie/?e
noa??; 33 (23,7%) — neoaeaiaoe?; 3 (2,2%) — o n?euenueeiio
ainiiaea?noa?; 73 (52,5%) — iai?aoethth/?.

Ca noaae??th iieieia?/iiai i?ioeano oai?? ?iciiae?eai? oae : ?? A — 14
(10,1%); ?? A — 56 (40,3%); ??? A — 19 (13,6%); ??? A — 50 (36,0%). O
113 (81,3%) ae?iie aecia/aii aaeaii- aai oeenoaaeaiiea?oeeiiio. Oea
ia?aaeaa/aei i?iaaaeaiiy i?iiaiaai? oa?ai?? o aeaeyae? oaeaaaiiaoa?ai??
(OAO) o eiiieaeniiio e?eoaaii?. OAO i?iaiaeeeany 5 ?ac?a ia oeaeaeaiue
?c ?aciaith aeicith 2 A?, noia?iith — 39 — 45 A? a caeaaeiino? a?ae
iaoia?noieia?? iooeeie, noaae?? caoai?thaaiiy oa ?iaeea?aeoaeueii?
?aae?i/ooeeaino?.

On? oai?? o?ueio a?oi i?iaeeaathoue o Eoaainuee?e iaeano?, yea
iaeaaeeoue aei i?iieneiaiai ?aa?iio Aeiiaano oa oa?aeoa?eco?oueny
aeieia?/ii iani?eyoeeaei iaaeieeoi?i na?aaeiaeuai. O aoiinoa?ia iia?o?y
aeeeaea?oueny 45 iaeiaioaaiue oe?aeeeaeo ?a/iaei ?c aenieei eeanii
iaaaciaee, ui neeaaea? aei 350 ea ia 1 iaoeaioey iaeano? ui??/ii. Ca
aeaieie iaeanii? a?ae?iiaoai?ieia?/ii? neoaeae, ?aae?aoe?eiee oii o
Eoaainueeo — a?ae 13 aei 18 ie?/a.

Eiio?ieueio a?oio neeaee 90 in?a — aeiii?e iaeanii? noaioe?? ia?aeeaaiiy
e?ia?, i?aeoe/ii caei?ia?, a?eii a?ae 21 aei 60 ?ie?a, ye? i?iaeeaathoue
o Eoaainuee?e iaeano?.

Ae?aaiinoeea aano?iaeoiaeaiaeueii? iaoieia?? na?aae oai?eo 1-? oa 2-?
a?oie a?oiooaaeany ia iayaiino? aeeniaioe/iiai e aieueiaiai neiae?ii?a.
E??i oiai, aea/aeany eeneioiooai?thth/a ooieoe?y oeoiea iaoiaeii
?I-iao??? oa ani??aoe?eii-oeo?iiao?e/iei iaoiaeii c aecia/aiiyi ia’?io,
eiioeaio?aoe?? a?eueii? nieyii? eeneioe, caaaeueii? eeneioiino?, BAO ?
SAO c a?noai?iiaei iiae?acieeii.

A on?o niinoa?aaeaiiyo ae?aaiic i?aeoaa?aeaeoaaany
o?a?iaano?iaeoiaeaiineii?/iei aeine?aeaeaiiyi (OAAeN) ?c a?noieia?/iei
aeine?aeaeaiiyi a?iioao?a. Ca aeaieie OAAeN, na?aae EIA o 50 (35,6%)
?a?no?oaaeiny o?aaeaiiy oeoiea ? aeaaiaaeoeyoeiaei? eeoee (AeIE) aac
aeano?oeoe??, a o 87 (63,5%) — c aeano?oeoe??th. O a?oi? ?ia?oiee?a
aeoioeyoi?iiai ae?iaieoeoaa aeano?oeoeai? ci?ie aano?iaeoiaeaiaeueii?
neeciai? aoee a iayaiino? o 102 (73,4%), aoee a?aenooi? — o 37 (26,6%).

Ia i?aenoaa? oeueo?acaoeiaiai aeine?aeaeaiiy oa aeine?aeaeaiiy
aeoiaeaiaeueiiai ai?noo na?aae in?a, ui caciaee aeieia?/iiai i?aneiao,
aecia/aeeny niieo/ai? o?aaeaiiy aeia/iiai i?oo?a oa ia/?iee. O 58
(42,3%) EIA niinoa??aaeeny ci?ie aeia/iiai i?oo?a, oa?aeoa?i? ia?aaaaeii
aeey o?ii?/iiai aaceai’yiiai oieaoeenoeoo, o 20 (14,6%) — ci?ie a
ia/?ioe?, ye? iaee i?noea i?e o?ii?/iiio aaiaoeo?. A na?aae ?ia?oiee?a
ae?iaieoeoaa eoaeieo aeoioeyoi??a i?iyae o?ii?/iiai oieaoeenoeoo
aeyaeyeeny o 39 (28,1%), a i?iyae o?ii?/iiai aaiaoeoo — o 6 (4,3%).

Ii?yae ?c caaaeueiii?eeiyoeie ee?i?/ieie oa ?ino?oiaioaeueieie iaoiaeaie
an?i oai?ei i?iaiaeeeeny aeine?aeaeaiiy o?ce/ii? aeoeaiino? i?ia?aeueieo
?a/iaei oe?eueii? e?ia? oa ?ioiieia?/i? aeine?aeaeaiiy.

Aeey ioe?iee o?ce/ii? aeoeaiino? i?ia?aeueieo ?a/iaei oe?eueii? e?ia?
iaie aaeaioiaaii oa aeei?enoaii iaoiae aia?ai-aeenia?n?eiiai
?aioaai?anueeiai aiae?co ca aeiiiiiaith ?ano?iaiai aeaeo?iiiiai
i?e?ineiio ?AI-101 c aia?ai-aeenia?n?eiei ?aioaai?anueeei aiae?caoi?ii
(AAeA?), yeee ?ai?oa o iaaeeoeei? ia canoiniaoaaany. Aiooaaeeny
i?aia?aoe e?ia? ca iaoiaeii “oianoi? e?aie?”, ye? iine?aeiaii
aenoooaaeeny, aaeooiii ia?iaeyeeny o eaia?? ?AI-101 ? ia?aiineeeny o
“iaea iiea” ia ae?ai. ?c i?enoaaeith AAeA? ?a?no?oaaeiny ?aioaai?anueea
aei?ii?ithaaiiy o aeaeyae? e?i?e (i?e?a) o?i?/ieo aeaiaio?a o
aeaeo?ii-aieueoao, ui aaoiiaoe/ii a?aeia?aaeaeiny ia iii?oi?? o
a?ao?/iiio aeaeyae?.

Ca aeiiiiiaith oaaeeoeue aia?a?e oa?aeoa?enoe/ieo ?aioaai?anueeeo e?i?e
Ea na??e aeaiaio?a aecia/aeany iayai?noue i?ia?ae?a a?ae iao??th aei
?o??th. I?e oeueiio aeiaaeeia oaee? (aia?a??) oa?aeoa?enoe/ii? e?i??
aeaiaioo caeaaeeoue a?ae eiai ii?yaeeiaiai iiia?o. E??i oiai,
?a?no?oaaeany ?ioaineai?noue i?e?a o?ce/ii? aeoeaiino? aeaiaio?a o
iaeneioi? a ?iioeuenao o naeoiaeo.

Ca iaoiaeii AAeA? aecia/aeany o a?ao?/iiio cia?aaeaii? iayai?noue
i?ia?ae?a: iao??th, iaai?th, aethi?i?th, oinoi?o, n??ee, e?aii?th,
oei?o, eae?th, eaeueoe?th, oeoaio, aaiaae?th, i?ae?, o?iio,
ia?aaioeth, cae?ca, eiaaeueoo, i?eaeth, oeeieo, aae?th, aa?iai?th,
ieo’yeo, naeaio, a?iio, no?iioe?th, ?o??th.

I?eeiath/e aei oaaae a?aeiini?noue oeueiai iaoiaeo, aeine?aeaeaiiy
i?iaiaeeeeny o aeeiai?oe?, ui aeicaieeei io?eiaoe a??ia?aei? aeai? i?i
ci?ie ??aiy aeoeaiino? i?ia?ae?a o oe?euei?e e?ia?. Ca ii?io aoei
i?eeiyoi ?acoeueoaoe aeine?aeaeaiue o aeiii??a, ui i?iaeeaathoue a
Eoaainuee?e iaeano?.

?ioiieia?/i? iaoiaee aeine?aeaeaiiy i?noeee: aecia/aiiy e?eueeino?
O-e?ioioeeo?a (A-?OE) ca Jondall et al. (1972) o iiaeeo?eaoe?? A.I.
*a?aaea?aa oa ?i. (1976); A-e?ioioeeo?a (AAN-?OE) ca Zola et al. (1979);
aeoeaieo (?aii?o) (Aaeo-?OE) ca Florey, Peetom (1976); oa?iinoaa?eueieo
(N-?OE) ca Wansbrough — Jones et al. (1978); a?noai?i/ooeeaeo (A*-?OE)
ca Iverson (1988); aooi?icaoeiooai?thth/eo (aooi-?OE) ca Caraux et al.
(1979); oaio?e?icaeaaeieo-?OE ca Limatibul et al.(1978) c aee?/aiiyi
oaio?e?i/ooeeaeo (OO*-?OE) oa oaio?e?i?acenoaioieo (OO?-?OE); ND3+
(O-e?ioioeeo?a), ND4+ (O-oaeia??a/?iaeoeoi??a), ND8+
(O-noi?ani??a/oeeoioienee?a), ND22+ (A-e?ioioeeo?a) oeeoioiene/iei
iaoiaeii ca aeiiiiiaith iiiieeiiaeueieo aioeo?e o??ie Ortho Diagnostic
Systems Inc. (USA); aeyaeaiiy ee?oeiii? nainea?e?caoe?? ca aeiiiiiaith
?aaeoe?? aaeueioaaiiy i?a?aoe?? eaeeioeeo?a (?AIE) o i?enooiino?
niaoeeo?/ieo aioeaai?a — e?iiiie?naoa?eae ia/?iee ethaeeie (EIE),
oeoieiaee aioeaai (OA), aioeaai aeaaiaaeoeyoeiaei? eeoee (AeIEA) ca
Rosenberg, David (1974); ioe?ieo ooieoe?iiaeueii? aeoeaiino? e?ioioeeo?a
ca aioo??oiueioe??yiith i?iaith c o?oiaaiaaetho?i?iii (OAA) ca Bonfort
et al. (1971) o iiaeeo?eaoe?? ss.Ae.Eaeoa (1979); aecia/aiiy ??aiy
?ioiiaeiaoe?i?a (Ig) A, M, G iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? a aae?
ca Mancini et al. (1965) oa ??aiy oee?eoethth/eo ?ioiieo eiiieaen?a
(Oe?E) c aea/aiiyi ?o iieaeoey?iiai neeaaeo iaoiaeii i?aoeei?oaoe?? a
?ic/eiao iie?aoeeaiaeeeieth 2,0%, 3,5%, 7,0% c iieaeoey?iith ianith 6000
aeaeueoii ca Digeon et al. (1977) o iiaeeo?eaoe?? A.I.O?ieiaa oa ?i.
(1986).

Ca ii?io a?aeeny ?ioii? iieacieee, ?ic?iaeai? i?aeeaoaae?aeueiith
eaai?aoi???th Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Noaoenoe/io ia?iaeo iaea?aeaieo aeaieo i?iaiaeeee ia IAII IBM PC-486 ca
aeiiiiiaith niaoe?aeueiiai iaeaoo i?eeeaaeieo i?ia?ai MathCAD-2.5 c
aeei?enoaiiyi ia?aiao?e/ieo ? iaia?aiao?e/ieo iaoiae?a. A??ia?aei?noue
aeaieo ioe?ithaaee ca e?eoa???i Nouethaeaioa (t); aca?iica’ycie i?ae
iieacieeaie aecia/aee ca eiao?oe??ioii ei?aeyoe?? I??niia (rxy);
aoaeoeai?noue niiniao e?eoaaiiy aea/aee ca iaoiaeii eooiaiai
ia?aoai?aiiy O?oa?a (j).

Aeine?aeaeaiiy iayaiino? oa o?ce/ii? aeoeaiino? i?ia?aeueieo ?a/iaei
e?ia? i?iaiaeeeeny o a?aeae?e? ai?iaoaaiiy, aeine?aeaeaiiy oa
noaiaea?oecaoe?? aoae?a ?inoeoooo “Oe?IAe?aoaeacaaaa/aiiy”. ?ioiieia?/i?
aeine?aeaeaiiy i?iaiaeeeeny o i?aeeaoaae?aeuei?e eaai?aoi???
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo, ?ioiieia?/i?e
eaai?aoi??? iaeaniiai iieieia?/iiai aeeniaina?o oa iaeanii? ee?i?/ii?
e?ea?i? i. Eoaainueea.

?acoeueoaoe aeine?aeaeaiue oa ?o iaaiai?aiiy. O EIA aano?iaeoiaeaiaeueia
iaoieia?y aoea i?aaenoaaeaia o?ii?/iei aano?iaeoiaeai?oii — 69 (50,4%),
aeeth/ath/e a?iceaiee; ae?aceiaith oai?iaith — 68 (49,6%), ia?aaaaeii
AeIE — 59 (49,1%), a oaeiae oeoiea ? AeIE.

Ee?i?/i? i?iyae caoai?thaaiue iai?oanooaaeeny, ia?aaeon?i, aeeniaioe/iei
neiae?iiii o 82,5% oai?eo, yeee a?aecia/aany ??ciiiai?oi?noth oa
noaa?euei?noth, aieiaiei /eiii, a in?a aac ae?acieo iaoiii?oieia?/ieo
ci?i o oeoieo ? AeIE o ii?aeiaii? ?c caoai?thaaiiyie
aaiaoia?e?a?ii? nenoaie.

Aieueiaee neiae?ii ?a?no?oaaany o 76 (55,5%) oai?eo, caeaa?eueoiai a
niieo/aii? c aeeniaioe/iei, ye i?aaeei, noa?oee, /anoi o aeaeyae?
aea?aaeaioo. Naiino?eiee aieueiaee neiae?ii aeyaeyany eeoa o 18 (13,1%)
e?ea?aeaoi??a. O 6 (4,4%) in?a iaa i?noea aacneiioiiiee ia?aa?a
aano?iaeoiaeaiaeueii? iaoieia??.

Oa?aeoa?iei aoei iaoa?iaoaaiiy anoaii-aaaaoaoeaieo ?iceaae?a, ye?
niinoa??aaeeny o 112 (81,8%) oai?eo, iniaeeai i?e iayaiino?
aeano?oeoeaieo ci?i o aano?iaeoiaeaiaeuei?e neecia?e. Ia??aeei
?a?no?oaaeeny aaaaoaoeai? e?ece.

Ca aeaieie aaiia?aie, o e?ea?aeaoi??a iniaeeaeo ci?i ia aeyaeaii,
o?eueee — oaiaeaioe?y aei eaeeiiai?? oa e?ioiiai??. Oaeiae
i?inoaaeoaaeany oaiaeaioe?y aei a?iiaeueaoi?iai?? ? aeeni?ioa?iai??,
a?ia?oieanoa?eiai?? oa a?ia?b-e?iii?ioa?iai?? iacaeaaeii a?ae
iaoiii?oieia?/ieo o?aaeaiue neeciai? e iayaiino? noiooiuei? iaoieia??.

E??i oiai, aecia/aeany a?ia?a?e??oa?iai?y, caeaa?eueoiai ca ?aooiie
ca’ycaii? o?aeoe??, aeenoa?iaioai?y, iniaeeai o aeaeyae? i?aeaeuaiiy
aeoeaiino? aeai?iai?iio?ainoa?ace (AeAO), aieiaiei /eiii, o oai?eo ?c
noiooiueith aaiaoia?e?a?iith iaoieia??th ye iciaea aaiaoi-oeaethey?ii?
iaaeinoaoiino?.

Noai eeneioiooai?thth/i? ooieoe?? oeoiea oa?aeoa?ecoaaany i?aaaethaaiiyi
aeio?eiaii? ooieoe??, a oaeiae cieaeaii? iaae i?aeaeuaiith, iacaaaeath/e
ia eieae?caoe?th e aeoeai?noue i?ioeano, ui iia’ycaii c aaaaoaoeaiith
aeen?aaoeyoe??th nae?aoe?? oeoieiaeo caeic ? noiooi?ie aaiaoia?e?a?ieie
caoai?thaaiiyie, ?iiae? c ?aoethenii aeia/?.

Na?aaei? iieacieee aeaa?o-aiaeeie nieyii? eeneioe neeaee: AAI — 2,6±0,2
iiieue; SAO — 9,2±0,8 iiieue.

O e?ea?aeaoi??a o?aaeaiiy neeciai? iaieiiee oeoiea ? AeIE /anoi aoee
iiiaeeii? o aeaeyae? o?ii?/ieo ae?acie, ye? o?eaaei ia ?oaoeththoueny,
“oe?eoieiaeo” ae?acie, ia??aeei a ii?aeiaii? c a?ic?yie. O 17 (12,5%)
oai?eo aeyaeyeeny aeano?oeoeai? ci?ie ? a oeoieo, ? a AeIE.

I?e aea/aii? o?ce/ii? aeoeaiino? i?ia?ae?a oe?eueii? e?ia? o EIA
aeyaeaii ae?aciee i?ia?aeueiee aeenaaeain ye na?aae iae?i-, oae ? na?aae
i?e?iaeaiaio?a, a oaeiae o ?o ni?aa?aeiioaii?. ??aaiue aeoeaiino?
iae?iaeaiaio?a aoa ca?eueoaiei o na?aaeiueiio a 2,4 ?aca ii??aiyii c
iieacieeaie aeiii??a. Aea nooi?iue c?inoaiiy aoa ia??aiii??iei, ui
coiiaeei a?aeiinia cieaeaiiy i?e?a aeoeaiino? ie?aieo aeaiaio?a.

Oae, a ii??aiyii? c eiio?ieueiith a?oiith ?a?no?oaaeiny ca?eueoaiiy
aeoeaiino? eae?th (?t<0,001); a?aeiinia cieaeaiiy aeoeaiino? iao??th (?t>0,05). Cieaeaiiy eiao?oe??ioa ni?aa?aeiioaiiy aeoeaiino? iao??th aei
eae?th (?t<0,001) a?aeaeaaei i?eai?/aiiy caoenieo ooieoe?e neeciai? oeoiea ? AeIE, cie?aia ci?ie nae?aoe?? ioeiciiai ae?eii?ioa?io e eoaeiiai a?ea?aiiaoiiai nae?aoo (iao??e), ? iineeaiiy aa?aneaieo aeanoeainoae oeoieiaiai nieo (eae?e). Oea i?ecaiaeeei aei a?iceaii-ae?aceiaiai iioeiaeaeaiiy neeciai?. ?noioia iineeaiiy aeoeaiino? eaeueoe?th (?t<0,001) coiiaeei cieaeaiiy eiao?oe??ioa ni?aa?aeiioaiiy aeoeaiino? iaai?th aei eaeueoe?th (?t<0,001). I?e oeueiio c?inoaiiy aeoeaiino? eaeueoe?th noi?iaiaeaeo?oueny i?aeaeuaiiyi eeneioii?iaeoeoe??, ii?ooo? eii?aeeiaoe?th ni?aa?aeiioaiiy aa?aneaiino? oeoieiaiai nieo oa no?eeino? caoeniiai aa?'??o, ui i?ecaiaeeoue aei iineaaeaiiy i?ioean?a ?aia?aoe?? e aeyaey?oueny o e?ea?aeaoi??a o iiiaeeiiino? o?aaeaiue, aeeth/ath/e iayai?noue a?ic?e oa ae?acie o o?aaiiio o?aeo?. I?aeaeuaiiy o?ce/ii? aeoeaiino? aethi?i?th (?t<0,001), e?aii?th (?t<0,001) a?aeia?aaea? caoenio ?aaeoe?th i?aai?cio ia iineeaiiy aeoeaii? nae?aoe?? oeoieiaeo caeic, a i?aeaeuaiiy aeoeaiino? n??ee (?t<0,001) - ?? o/anoue o noaa?e?coaaii? ee?oeiieo iaia?ai, ye? iioeiaeaeaii i?e ae?? aa?aneaieo /eiiee?a iaaeieeoiueiai na?aaeiaeua. Uiaei o?ce/ii? aeoeaiino? i?e?iaeaiaio?a o oe?euei?e e?ia?, oi aecia/aeany ia??aiii??i?noue i?aeaeuaiiy ??aiy a 1,7 - 6,4 ?aca o ii??aiyii? c eiio?ieueiith a?oiith. Oae, ?a?no?oaaeiny ia?aaaaeia iineeaiiy aeoeaiino? aaaeeeo iaoae?a. I?e oeueiio c?inoaiiy o?ce/ii? aeoeaiino? cae?ca (?t<0,001), aaiaae?th (?t<0,001) coiiaeaii iineeaiiyi i?ioean?a ia?aeeniiai ieeneaiiy e?i?ae?a, eaoae?caoi?aie yeeo i?e ?aae?aoe?ei?e ae?? aenooiathoue aeacai? aeaiaioe. Iaeii/anii ci?ie iieaciee?a ia?aaioeth (?t<0,001) oa oeeieo (?t<0,001) iia'ycai? c ?o o/anoth a nenoai? aioeieneaeaioieo oa?iaio?a, aeoeai?noue yeeo c?inoa? ii?yae ?c eiiiainaoi?ieie iaoai?ciaie i?aai?cio o a?aeiia?aeue ia iineeaiiy i?ioean?a a?eueii-?aaeeeaeueiiai ieeneaiiy, aea c /anii i?ney ii?ii?ithaaiiy aeoeai?noue cieaeo?oueny. E??i oiai, iayai?noue oeueoea?iaaiiiai i?ioeano a neecia?e oeoiea ? AeIE ii?ooo? iai?i oeeieo, yeee ia? aeanoeaino? aioaaii?noa aei iioeiaeaeoth/eo oaeoi??a. I?eaa?oa? aei naaa oaaao iieaciee i?ae?, yeee c??n o 6,4 ?aca (?t<0,001), ui ni?eyei ca?eueoaiith eiao?oe??ioa ni?aa?aeiioaiiy aeoeaiino? i?ae? aei oeeieo (?t<0,001) oa a?aeiiniiio ciaioaiith ??aiy oeeieo. ?noioia i?aeaeuaiiy aeoeaiino? i?ae? a?aeaeaa ?? aeanoeaino? ye oeeoii?ioaeoi?o aano?iaeoiaeaiaeueii? neeciai? oa ?aae?ii?ioaeoi?o ca ?aooiie aeoeaaoe?? aaaaoueio oa?iaio?a. Oiio ae?aci? ci?ie i?e?a aeoeaiino? i?ae? ca?a?no?iaai? o e?ea?aeaoi??a ?c ii?aeiaiiyi aano?iaeoiaeaiaeueii? iaoieia?? oa o?aaeaiiy ia/?iee. Aiae?c ci?i iieaciee?a ni?aa?aeiioaiiy iae?i- oa i?e?iaeaiaio?a, cie?aia ia i?eeeaae? eiao?oe??io?a ni?aa?aeiioaiiy aeoeaiino? iao??th aei aaiaae?th, n??ee aei i?ae? na?ae/eoue i?i ?o c?ooaiiy, a naia - a??ia?aeia ciaioaiiy ca ?aooiie a?eueo ae?acieo ci?i i?e?iaeaiaio?a, ui noaa?aeaeo? iayai?noue i?ia?aeueiiai aeenaaeaino e?ia?. Ioaea, i?ia?aeueiee aeenaaeain e?ia? o e?ea?aeaoi??a oa?aeoa?eco?oueny i?aaaethaaiiyi o?ce/ii? aeoeaiino? eae?th, eaeueoe?th, aaaeeeo iaoae?a, iniaeeai i?ae?, oa a?aeiiniei cieaeaiiyi ??aiy aeoeaiino? iao??th, iaai?th, oeeieo. Ci?ie o?ce/ii? aeoeaiino? i?ia?ae?a ei?aeththoue ?c ii?ooaiiyie oa?iaioieo, nae?aoi?ieo ? ?aaaia?aoi?ieo i?ioean?a ? a?aeaeaathoue oyaee?noue aano?iaeoiaeaiaeueieo o?aaeaiue. I?eioeeiiai, ui aeyaeai? ii?ooaiiy o?ce/ii? aeoeaiino? i?ia?aeueieo ?a/iaei e?ia? o oai?eo ia caeaaeaee a?ae aeoeaiino? iaoiii?oieia?/ieo o?aaeaiue ? iayaiino? noiooiuei? aaiaoia?e?a?ii? iaoieia??, ui aeaco? ia ?oi?e ca'ycie ?c ciai?oi?i ii?ii?ithaaiiyi. Ca aeaieie ?ioiieia?/ieo aeine?aeaeaiue, o e?ea?aeaoi??a ca?a?no?iaai? ci?ie ye o ee?oeii?e eaioe? ?ioi?oaoo, oae ? o aoii?aeuei?e eaioe?. Oae, o ee?oeii?e eaioe? aecia/aeanue O-e?ioiiai?y - cieaeaiiy aaniethoii? e?eueeino? A-?OE a 2,0 ?ace (?t<0,001), ND3+ - a 1,7 ?aca (?t<0,001) o ii??aiyii? c eiio?ieueieie iieacieeaie. I?e oeueiio cacia/aii ?noioia ciaioaiiy aaniethoii? e?eueeino? OO?-?OE (?t<0,001), ND4+ (O-oaeia??a/?iaeoeoi??a) (?t<0,001), ui i?ecaaei aei cieaeaiiy ?ioii?aaoeyoi?iiai ?iaeaeno (???) OO?/OO* aei 1,54±0,07 (?t<0,001), CD4/CD8 - aei 1,17±0,08 (?t<0,001). I?inoaaeaia oaiaeaioe?y aei i?aeaeuaiiy noi?ani?ieo noaiiioeyoe?e - N-?OE (?t>0,05), A*-?OE (?t>0,05). E??i oiai, niinoa??aaeiny a??ia?aeia
ciaioaiiy aaaaoi?aoeaioi?ieo ?OE, Aaeo-?OE, aooi-?OE. Iaeii/anii
?a?no?oaaany aeuee ??aaiue I-ee?oei (?t<0,001). Aeai? i?i e?euee?noue A-e?ioioeeo?a ia aoee a??ia?aeieie. I?iaaaeaiiy ?AIE o a?eueoino? oai?eo aeyaeei iayai?noue ee?oeiii? nainea?e?caoe?? aei oeaieiieo aioeaai?a. Anoaiiaeaii i?yio ei?aeyoe?th i?ae ??aiai O-e?ioioeeo?a (CD3+) ? i?a?aoe?eiei ?iaeaenii (I?) c OA o ?AIE (r=+0,568), a oaeiae i?ae ??? CD4/CD8 ? I? c OA (r=+0,648). O aoii?aeuei?e eaioe? iaea?eueo ?noioi? ci?ie aecia/aeeny o ca?eueoaii? ??aiy Oe?E - a 2,0 ?ace (?t<0,001), iniaeeai ae??aii- oa na?aaeiueiiieaeoey?ieo eiiieaen?a. Oaeiae niinoa??aaeiny cieaeaiiy ??aiy Ig G (?t<0,001) oa Ig M (?t>0,05) ? oaiaeaioe?y aei c?inoaiiy Ig A
(?t>0,05).

O aeiaaeeao ii?aeiaii? aano?iaeoiaeaiaeueii? iaoieia?? c
aaiaoia?e?a?iith oa i?e iiiaeeiiino? o?aaeaiue oeoieo ? AeIE aecia/aeany
a?eueo cia/ia O-e?ioiiai?y ? cieaeaiiy ???, I? c OA, AeIEA, EIE o ?AIE,
a oaeiae c?inoaiiy Oe?E.

Ioaea, a noai? ?ioi?oaoo o EIA aecia/aii iayai?noue aoi?eiii?
?ioiieia?/ii? iaaeinoaoiino? ca a?aeiiniei noi?ani?iei aa??aioii, yea
noi?iaiaeaeoaaeany cieaeaiiyi ooieoe?iiaeueii? aeoeaiino? O-ee?oei. E??i
oiai, aeyaeaii noeeuei?noue aei aooi?ioiieo i?ioean?a, ye? iiaeeaethaaea
aeen?ioiiaeiaoe?iai?y.

I?eeiath/e aei oaaae ci?ie i?ia?aeueiiai oa ?ioiiiai noaoono, i?iaaaeaii
ii??aiyeueiee aiae?c iieaciee?a. Aecia/aia ei?aeyoe?eia caeaaei?noue
i?ae aaniethoiith e?euee?noth O-e?ioioeeo?a (ND3+) oa ??aiai o?ce/ii?
aeoeaiino? i?ae? a oe?euei?e e?ia? (r= -0,602); i?ae ??aiai Oe?E oa
aeoeai?noth i?ae? a e?ia? (r=+0,546). Anoaiiaeaii i?yio ei?aeyoe?th i?ae
??? ND4/ND8 ? eiao?oe??ioii ni?aa?aeiioaiiy aeoeaiino? n??ee aei i?ae?
(r=+0,629).

Iayai?noue aca?iica’yceo ca iaaaaeaieie iieacieeaie na?ae/eoue i?i
ni?euei?noue iaoiaaiaoe/ieo iaoai?ci?a ii?ooaiue o oai?eo ?c
a?iceaii-ae?aceiaeie o?aaeaiiyie neeciai? oeoiea ? AeIE i?e ae??
?ii?coth/iai aei?ii?ithaaiiy, ui coiiaeaii ii?ooaiiyie o?ce/ii?
aeoeaiino? i?ia?ae?a, ye? iathoue ?ioiiiiaeoethth/? aeanoeaino? (cae?ci,
i?aeue, oeeie, oeoai, ia?aaiaoeue), c iaoaaie?/iith ?ioiiaeai?an??th.

O oai?eo 2-? a?oie iaoieia?y i?aai?a o?aaeaiiy aoea i?aaenoaaeaia
o?ii?/iei aano?iaeoiaeai?oii — 43 (30,9%) ? ae?aceiaith oai?iaith — 96
(69,1%), aieiaiei /eiii AeIE — 78 (56,2%).

Na?aae ee?i?/ieo i?iya?a aano?iaeoiaeaiaeueii? iaoieia?? oaeiae
aeii?ioaaa aeeniaioe/iee neiae?ii, yeee aecia/aany o 109 (78,4%) oai?eo
iacaeaaeii a?ae aeoeaiino? o?aaeaiue aano?iaeoiaeaiaeueii? neeciai?.

Aieueiaee neiae?ii ?a?no?oaaany o 69 (49,6%) oai?eo, ?iiae? a?i
i?aaethaaany aeeniaioe/ieie ?iceaaeaie. I?eoiaaiee ia?aa?a caoai?thaaiue
aeyaeaii o 7 (5,0%) oai?eo.

O ii??aiyii? c 1-th a?oiith, o oai?eo 2-? a?oie aano?iaeoiaeaiaeueia
iaoieia?y noi?iaiaeaeoaaeany iaa?ioe/ieie ?iceaaeaie, ye? niinoa??aaeeny
o 110 (79,1%) in?a. ?iiae? aecia/aeiny ii?aeiaiiy ?o ?c
anoaii-aaaaoaoeaiei eiiiiiaioii, ui iaei i?noea ye o oai?eo ?c
aeano?oeoeaieie, oae ? aac aeano?oeoeaieo ci?i o oeoieo ? AeIE.

Ca aeaieie aaiia?aie, o oai?eo aeyaeaii oaiaeaioe?th aei a?eo?iiai??,
aiai??, eaeeiiai?? c e?ioiiai??th iacaeaaeii a?ae iaoiii?oieia?/ieo ci?i
o aano?iaeoiaeaiaeuei?e neecia?e ? a?ae noiooi?o caoai?thaaiue. I?ioa,
aeyaeaia caeaaei?noue ??aiy aaiiaeia?io a?ae noaaeo ?iaioe c oe?aeeeaeie
?a/iaeiaie (r=-0,459). Oaeiae aecia/aia ei?aeyoe?y i?ae ??aiai
eaeeioeeo?a ? noaaeai ?iaioe (r= -0,431).

Ca?a?no?iaaii cieaeaiiy ??aiy aeueaoi?i?a, iniaeeai i?e iayaiino?
o?eaaeiai noaaeo a aeoioeyoi?iiio ae?iaieoeoa?. ?nio? ei?aeyoe?eiee
ca’ycie i?ae e?euee?noth aeueaoi?i?a ne?iaaoee e?ia? oa noaaeai ?iaioe
(r=-0,322).

O oai?eo ?c noiooi?ie caoai?thaaiiyie aaiaoia?e?a?ii? nenoaie
niinoa??aaeany oaiaeaioe?y aei i?aeaeuaiiy aeoeaiino? AeAO. Aecia/aia
noeeuei?noue aei ii?ooaiue e?i?aeiiai iai?io a ca’yceo c a?eiaei
oaeoi?ii iacaeaaeii a?ae aeoeaiino? aano?iaeoiaeaiaeueieo o?aaeaiue.

Aecia/aeeny ?noioi? ci?ie eeneioiooai?thth/i? ooieoe?? oeoiea, ye?
iia’ycai? c noiooiueith aaiaoia?e?a?iith iaoieia??th oa iino?eiith
ae??th aaaeeeo iaoae?a ia i?aai?ci i?ae /an ?iaioe.

Na?aaei? iieacieee aeaa?o-aiaeeie nieyii? eeneioe neeaee: AAI — 2,1±0,2
iiieue; SAO — 5,8±0,7 iiieue. Aeii?ioaaei cieaeaiiy eeneioii?iaeoeoe??,
iniaeeai a noeioeueiaaio oaco, iaa?oue o oai?eo ?c aeano?oeoe??th
aano?iaeoiaeaiaeueii? neeciai?.

Ca aeaieie OAAeN, o a?eueoino? niinoa?aaeaiue o?aaeaiiy neeciai?
iaieiiee eieae?coaaeeny o eoeiaeoe? AeIE, ia?aaaaeii ?cieueiaaiiai
oa?aeoa?o. O ii??aiyii? c EIA ??aeei niinoa??aaeany iayai?noue a?ic?e
oa, iaaiaee, /anoi — ?oaoeaaeo ci?i, ye? aoee o 49 (35,3%) oai?eo. Ia
iaeiiio ??ai? a iaio a?oiao aoea /anoioa ii?aeiaieo o?aaeaiue oeoieo ?
AeIE.

I?e aeine?aeaeaii? i?ia?aeueieo ?a/iaei oe?eueii? e?ia? aiaeia?/ii, ye ?
na?aae EIA, iaa i?noea aeenaaeain iae?i- oa i?e?iaeaiaio?a. Aea
i?aeaeuaiiy o?ce/ii? aeoeaiino? iae?iaeaiaio?a o oe?euei?e e?ia? o
oai?eo 2-? a?oie a na?aaeiueiio aoei o?eueee a 1,8 ?aca o ii??aiyii? c
aeiii?aie.

Oae, aecia/aeiny ia?aaaaeia ca?eueoaiiy i?e?a aeoeaiino? eae?th
(?t<0,001), ui coiiaeei a?aeiinia cieaeaiiy aeoeaiino? iao??th (?t>0,05). Eiao?oe??io ni?aa?aeiioaiiy aeoeaiino? iaai?th aei eaeueoe?th
cieceany (?t<0,001), ui a?aeaoaaeiny caaaeyee ?noioiiio iineeaiith i?e?a aeoeaiino? eaeueoe?th (?t<0,001) ? i?aeoaa?aeaeoaaei ooeiaeaeoth/o ae?th eiai ia ee?oeii? iaia?aie i?ae aieeaii o?i?/ieo oaeoi??a, cie?aia aaaeeeo iaoae?a. Niinoa??aaeiny ca?eueoaiiy ??aiy aeoeaiino? n??ee (?t<0,001), aethi?i?th(?t<0,001), e?aii?th (?t<0,001). ?a?no?oaaeany ia??aiii??i?noue ci?i o?ce/ii? aeoeaiino? i?e?iaeaiaio?a, iniaeeai aaaeeeo iaoae?a - i?aeaeuaiiy a 1,3 - 5,2 ?aca o ii??aiyii? c iieacieeaie aeiii??a. I?e oeueiio ??aaiue aeoeaiino? i?eaeth aoa iineeaiee o 4,1 ?aca (?t<0,001), a cae?ca - a 5,2 ?aca (?t<0,001). Cia/ii c??n eiao?oe??io ni?aa?aeiioaiiy aeoeaiino? cae?ca aei oeeieo (?t<0,001). Iaea?eueoa c?inoaiiy o?ce/ii? aeoeaiino? cae?ca iia'ycaia c iaiao?aei?noth caaacia/aiiy i?aeaeuaiiai ??aiy aia?aaoe/iiai iai?io, ui, c ?aooith, ni?ey? ciaioaiith ooeiaeaeoth/i? ae?? ?aaeoeaieo iaoaaie?o?a i?ae aieeaii enaiia?ioee?a. I?aeaeuaiiy i?e?a aeoeaiino? i?eaeth a?aeaeaa? aeoeaaoe?th i?ioean?a nainea?e?caoe??, ui noaa?aeaeo? aieea ia ?ia?oiee?a i?iieneiaiai ae?iaieoeoaa o?i?/ieo ?a/iaei. Ia??aiii??i?noue c?inoaiiy i?e?a aeoeaiino? i?ia?aeueieo ?a/iaei ni?e/eieea ci?ie o ni?aa?aeiioaii? iae?i- oa i?e?iaeaiaio?a, cie?aia ?noioia cieaeaiiy iieacieea iao??th aei aaiaae?th (?t<0,001). Uiaei aeyaeaieo ci?i aeoeaiino? i?ia?ae?a, oi aiie aoee iacaeaaeieie a?ae aeaeyaeo iaoiii?oieia?/ieo o?aaeaiue neeciai? oa a?ae iayaiino? ii?aeiaii? iaoieia??. Ioaea, o ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa ia? i?noea i?ia?aeueiee aeenaaeain, iia'ycaiee c ia?aaaaeiei iineeaiiyi o?ce/ii? aeoeaiino? eae?th, eaeueoe?th, aaaeeeo iaoae?a, iniaeeai aaiaae?th, i?eaeth, cae?ca, c a?aeiiniei cieaeaiiyi ??aiy aeoeaiino? iao??th, iaai?th, oeeieo, ui a?aeaeaa? noai eiiiainaoi?ii-aaeaioaoe?eieo ?aaeoe?e o ca’yceo c aeaci?aai?caoe??th i?ioean?a iaoaaie?cio ia oii? aenieiai ??aiy nainea?e?caoe?? i?ae /an o?eaaeiai eiioaeoo c aaaeeeie iaoaeaie. I?iaaaeai? aeine?aeaeaiiy noaio ?ioi?oaoo o ?ia?oiee?a, eii-oaeooth/eo ?c aaaeeeie iaoaeaie, ca?a?no?oaaee iayai?noue ci?i o ee?oeii?e ? aoii?aeuei?e eaieao. Ia?aaeon?i, aecia/aeiny cieaeaiiy O-e?ioioeeo?a - A-?OE (?t<0,001), ND3+ (?t<0,001), oi/a nooi?iue cieaeaiiy aoa iaioei, i?ae o EIA; a oaeiae i?eai?/aiiy ?oiuei? ooieoe?iiaeueii? aeoeaiino?. A??ia?aeii ciaioeany I? c oeaieiieie aioeaaiaie o ?AIE. I?e oeueiio iaea?eueo ?noioia O-e?ioiiai?y noi?iaiaeaeoaaea aano?iaeoiaeaiaeuei? caoai?thaaiiy c o?ii?/ii-?aoeeaeeaiei ia?aa?aii, ye i?aaeei, ca iayai?noth ii?aeiaieo a?iceaii-ae?aceiaeo o?aaeaiue oeoiea ? AeIE, ui niinoa??aaeiny o ?ia?oiee?a, noaae ?iaioe yeeo aoa a?eueoei ca 15 ?ie?a. Ca?a?no?iaaii ei?aeyoe?eiee ca'ycie i?ae aaniethoiith e?euee?noth O-e?ioioeeo?a (A-?OE) ? noaaeai ?iaioe (r=-0,589); i?ae CD3+ ? I? c OA a ?AIE (r=+0,530). Niinoa??aaany O-noaiiioeyoe?eiee aeenaaeain. Iaei i?noea ciaioaiiy aaniethoii? e?eueeino? OO?-?OE (?t<0,001), ND4+ (?t<0,001). Aaniethoiee ??aaiue OO*-?OE ? ND8+ ?noioii ia a?ae??ciyany a?ae ii?ie (?t>0,05). ???
OO?/OO* aeinyaaa 1,86±0,11 (?t<0,001), ND4/ND8 - 1,33±0,08 (?t<0,001). Anoaiiaeaii i?yio ei?aeyoe?th i?ae ??? CD4/CD8 ? I? c OA a ?AIE (r=+0,592). I?inoaaeaia oaiaeaioe?y aei i?aeaeuaiiy N-?OE (?t<0,05) ? A*-?OE (?t<0,01) o a?aeiini?e e?eueeino?. Ci?ie A-e?ioioeeo?a ? I-ee?oei ia aoee a??ia?aeieie. Oaeiae ?a?no?oaaeiny cieaeaiiy aaniethoiiai ??aiy Aaeo-?OE, aaaaoi?aoeaioi?ieo ?OE (?t<0,001) ? i?aeaeuaiiy a?aeiiniiai ??aiy “iaiiaieo” ?icaoie (?t<0,001), ui na?ae/eei i?i i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? O-ee?oei. E??i oiai, aecia/aeiny cieaeaiiy aooi-?OE (?t<0,001) ? c?inoaiiy Oe?E (?t<0,001), iniaeeai iaoiaaiieo eiiieaen?a, caeaa?eueoiai i?e ii?aeiaii? c aaiaoia?e?a?iith iaoieia??th. Anoaiiaeaii cai?ioio ei?aeyoe?th i?ae ??aiai aooi-?OE ? noaaeai ?iaioe a oiiaao ae?? aaaeeeo iaoae?a (r=-0,446); i?yio ei?aeyoe?th i?ae ??aiai Oe?E ? noaaeai ?iaioe (r=+0,406). Ia oeueiio oii? iaei i?noea cieaeaiiy ?ioiiaeiaoe?i?a, iniaeeai Ig M (?t<0,01), Ig G (?t<0,01), ui i?aeoaa?aeaeoaaei i?eai?/aiiy ?ioiiiai caoenoo aano?iaeoiaeaiaeueii? neeciai?. ?ioiiee aiiainoac o ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa a?aecia/aany aeao?oeeoii ? ooieoe?iiaeueiith iaaeinoaoi?noth O-ee?oei, ia?aaaaeii ca ?aooiie O-oaeia??a, i?e noeeueiino? aei i?ioean?a nainea?e?caoe??. Ia i?aenoaa? ci?i i?ia?aeueiiai oa ?ioiiiai aaeaino o oai?eo 2-? a?oie aeciaii iayai?noue aca?iica'yceo i?ae ieie, a naia: ei?aeyoe?eio caeaaei?noue i?ae aaniethoiith e?euee?noth O-e?ioioeeo?a (ND3+) ? ??aiai o?ce/ii? aeoeaiino? cae?ca (r=-0,514); i?ae aeoeai?noth cae?ca ? ??aiai Oe?E (r=+0,527); i?ae ??? ND4/ND8 ? eiao?oe??ioii ni?aa?aeiioaiiy aeoeaiino? n??ee aei i?ae? (r=+0,624). Anoaiiaeaiiy oeeo ca'yce?a aeiaiaeeoue ni?euei?noue iaoai?ci?a ?icaeoeo ii?ooaiue i?ia?aeueiiai oa ?ioiiiai noaoono a oiiaao i?iieneiaiai oaeoi?o, cie?aia ae?? aaaeeeo iaoae?a, o oai?eo c aeano?oeoeaieie o?aaeaiiyie aano?iaeoiaeaiaeueii? neeciai? i?e cieaeaii? eeneioii?iaeoeoe??. O 3-e a?oi? oai?eo aei i?iaaaeaiiy i?iiaiaai? oa?ai?? a?aeaoaaeeny ci?ie, oa?aeoa?i? aeey iieieia?/iiai i?ioeano, a oaeiae iia'ycai? ?c aieeaii aeieia?/ii? ianoaiiaee i?iaeeaaiiy. I?e oeueiio caeaa?eueoiai i?inoaaeaia oaiaeaioe?y aei a?eo?iiai?? oa eaeeiiai??. O ii??aiyii? c eiio?ieueiith a?oiith aecia/aeeny ci?ie o?ce/ii? aeoeaiino? i?ia?ae?a. I?e oeueiio na?aae iae?iaeaiaio?a a??ia?aeii iineethaaeany o?eueee aeoeai?noue eaeueoe?th. Uiaei i?e?iaeaiaio?a, oi iaei i?noea ca?eueoaiiy i?e?a aeoeaiino?: oeoaio (?t<0,01), cae?ca (?t>0,05), i?ae? (?t<0,001) ? oeeieo (?t<0,001); a oaeiae ciaioaiiy ??aiy aeoeaiino? aaiaae?th (?t<0,01), ia?aaioeth (?t>0,05), eiaaeueoo (?t<0,001), aa?iai?th (?t<0,001). Cia/ia ca?eueoaiiy iieaciee?a i?ae? ? oeeieo na?ae/eoue i?i c?inoaiiy aeoeaiino? oa?iaio?a i?ae /an ?inoo iooeei. Niinoa??aaeeny ?ioiieia?/i? c?ooaiiy. Aeyaeaii ciaioaiiy aaniethoii? e?eueeino? O-e?ioioeeo?a (A-?OE, ND3+) a 1,9 ?aca (?t<0,001); ?noioia cieaeaiiy OO?-?OE (?t<0,001), ND4+ (?t<0,001), ui coiiaeei ciaioaiiy ??? OO?/OO* aei 1,02±0,06 (?t<0,01); ND4/ND8 - 0,95±0,06 (?t<0,01). E??i oiai, aecia/aeiny ciaioaiiy aaaaoi?aoeaioi?ieo ?OE (?t<0,001), Aaeo-?OE (?t<0,01). Iai?ioe, ?a?no?oaaany aenieee ??aaiue I-ee?oei (?t<0,01). A??ia?aeiino? a ci?iao A-e?ioioeeo?a, O-noi?ani??a ia aeciaii. Iaea?eueo ?noioii cieceeany aaniethoia e?euee?noue aooi-?OE - a 6,4 ?aca (?t<0,001), ui aeaiiino?oaaei aenieee ??aaiue aooi?ioiieo i?ioean?a. O ?acoeueoao? i?iaaaeaiiy aioo??oiueioe??yii? i?iae c OAA aeyaeaii cieaeaiiy ooieoe?iiaeueii? aeoeaiino? O-ee?oei. Aecia/aii i?yio ei?aeyoe?th i?ae ??aiai ? ooieoe?iiaeueiith aeoeai?noth O-ee?oei (r=+0,702). Oaeiae iaei i?noea i?aeaeuaiiy ??aiy Oe?E - a 2,7 ?aca (?t<0,001), aieiaiei /eiii na?aaeiuei- oa ae??aiiiieaeoey?ieo eiiieaen?a, cieaeaiiy Ig M (?t>0,05), Ig G (?t<0,01), oaiaeaioe?y aei ca?eueoaiiy Ig A (?t>0,05).

Ia oeueiio oii?, ci?iaiiio c naiiai ii/aoeo, a iieieia?/ieo oai?eo
i?iaiaeeeany ia?aaeiia?aoe?eia OAO, yea ni?e/eieea o 78,9% ?icaeoie
neiae?iio i?iiaiaaeo ?aaeoe?e, ui noi?iaiaeaeoaaany caaaeueieie oa
i?noeaaeie i?iyaaie.

Neiae?ii i?iiaiaaeo ?aaeoe?e iai?oanooaaany anoaii-iaa?ioe/ieie
?iceaaeaie, oe??yieie o?aaeaiiyie, aaiaoieia?/ieie c?ooaiiyie,
aeeniaioe/ieie ?iceaaeaie, e?noeiai-noaeiaiaei neiae?iiii, eaoa?aeueiith
oa oaiia?aoo?iith ?aaeoe??th.

O ?yae? niinoa?aaeaiue i?iaaaeaiiy OAO i?ecaaei aei caaino?aiiy
noiooi?o caoai?thaaiue.

Ca aeaieie aaiia?aie, aeyaeyeany iiaeaeueoa eaeeiiai?y (?t<0,05) c a?aeiiniei ca?eueoaiiyi aic?iio?e?a (?t<0,001), iaee/eiyaea?ieo (?t<0,05), a?aeiiniei ? aaniethoiei ciaioaiiyi e?ioioeeo?a (?t<0,001). ?iiae? ??aaiue eaeeioeeo?a aeinyaaa e?eoe/iiai, ui iio?aaoaaei ia?a?ae o OAO ? ei?eaoth/i? oa?ai??. I?iaaaeaiiy OAO i?ecaiaeeei aei c?ooaiue o aaeain? i?ia?ae?a oe?eueii? e?ia?. O ii??aiyii? c ii/aoeiaei ??aiai na?aae iae?iaeaiaio?a aecia/aeiny a??ia?aeia iineeaiiy o?ce/ii? aeoeaiino? eae?th, iaai?th, eaeueoe?th, oinoi?o, aethi?i?th, n??ee. ??aaiue aeoeaiino? iao??th cieceany (?t>0,05).

Ci?ie i?e?a aeoeaiino? i?e?iaeaiaio?a i?ney i?iiaiaai? oa?ai?? aoee
a?eueo ia??aiii??i?. Aecia/aany i?ia?aeueiee aeenaaeain ?c ia?aaaaeiei
iineeaiiyi aeoeaiino? cae?ca a 4,5 ?aca (?t<0,001) oa a?aeiiniei ciaioaiiyi ??aiy oeeieo (?t>0,05), aa?iai?th (?t<0,01), a oaeiae ciaioaiiyi iao??th (?t>0,05).

Oea i?ecaaei aei ci?ie eiao?oe??io?a ni?aa?aeiioaiiy iieaciee?a iae?i- ?
i?e?iaeaiaio?a — cieceeeny eiao?oe??ioe ni?aa?aeiioaiiy aeoeaiino?
iao??th aei aaiaae?th (?t<0,001) ? n??ee aei i?ae? (?t>0,05).

OAO ni?aaeyea ?ioiiaeai?aneaio ae?th. O ee?oeii?e eaioe? ?ioi?oaoo
aecia/aeiny iineeaiiy aaniethoii? O-e?ioiiai?? (?t<0,001) a?ae ii/aoeiaiai ??aiy. I?e oeueiio iaeii/anii ciaioeeany aaniethoia e?euee?noue OO?-?OE (?t<0,001), ND4+ (?t<0,001) oa OO*-?OE (?t<0,001), ND8+ (?t<0,001), a oaeiae ??? - OO?/OO* aei 0,79±0,04 (?t<0,001), ND4/ND8 - 0,80±0,04 (?t<0,05). E??i oiai, niinoa??aaeiny ciaioaiiy aaniethoiiai ??aiy A-e?ioioeeo?a (AAN-?OE ? ND22+) (?t<0,001). Oaea ae oaiaeaioe?y i?inoaaeaia i?ney i?iiaiaai? oa?ai?? o Aaeo-?OE, aaaaoi?aoeaioi?ieo ?OE, N-?OE, A*-?OE ? aooi-?OE. A??ia?aeii ciaioeany iieaciee i?iae c OAA, ui a?aeaeaaei i?eai?/aiiy ooieoe?iiaeueii? aeoeaiino? O-ee?oei. O aoii?aeuei?e eaioe? ?ioi?oaoo aecia/aeiny ca?eueoaiiy ??aiy Oe?E (?t<0,05), ia?aaaaeii ae??aiiiieaeoey?ieo eiiieaen?a. I?ioa ci?ie ??aiy ?ioiiaeiaoe?i?a iaee oaiaeaioe?th aei cieaeaiiy, iaeiae ia aoee a??ia?aeieie. Oaeei /eiii, ia?aaeiia?aoe?eia OAO i?ecaaea aei iiaeeaeaiiy O-e?ioiiai??, noaiiioeyoe?eiiai aeenaaeaina, aeoeaaoe?? i?ioean?a aooinainea?e?caoe??. Anoaiiaeaii caeaaei?noue ci?i i?ia?aeueiiai oa ?ioiiiai aaeaino o iieieia?/ieo oai?eo i?ae /an OAO - i?ae aaniethoiei ??aiai ND3+ (O-e?ioioeeo?a) ? ??aiai aeoeaiino? cae?ca (r=-0,468); i?ae ??aiai Oe?E ? ??aiai aeoeaiino? cae?ca (r=+0,504); i?ae ??? ND4/ND8 ? eiao?oe??ioii ni?aa?aeiioaiiy o?ce/ii? aeoeaiino? n??ee aei i?ae? (r=+0,564). Ioaea, eieaeueia ii?ii?ithaaiiy o iieieia?/ieo oai?eo noi?iaiaeaeo?oueny ?icaeoeii neiae?iio i?iiaiaaeo o?aaeaiue, yeee iaoa?iao?oueny ia ii/aoeia? ci?ie a i?aai?ci?, ui iia'ycai? c iieieia?/iei i?ioeanii oa aieeaii iaaeieeoiueiai na?aaeiaeua. Ia oeueiio oii? aecia/athoueny ii?aeiai? ii?ooaiiy i?ia?aeueiiai oa ?ioiiiai aaeaino. sse iieacaee ?acoeueoaoe aeanieo aeine?aeaeaiue 3-o a?oi oai?eo, aieea ciai?oiueiai ? eieaeueiiai ii?ii?ithaaiiy, a oaeiae aeieia?/iee i?aneia aaaeeeo iaoae?a a?aeaeaa?oueny o aeaeyae? i?ia?aeueiiai oa ?ioiiiai aeenaaeaino, ui iaaiith i??ith i?aeoaa?aeaeo? ?ai?oa aeneiaeaia iieiaeaiiy aaeaioaoe?eiiai neiae?iio i?i noa?aioeii?noue a?aeiia?ae? a?ieia?/ii neeaaeiiai i?aai?cio ia aeno?aiaeuei? aeciaaii? ae??. Aiae?c aea/aiiy ee?i?/ieo i?iya?a aano?iaeoiaeaiaeueii? iaoieia??, a oaeiae ?acoeueoao?a aeine?aeaeaiiy i?ia?aeueiiai oa ?ioiiiai noaoono o EIA ? ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa iieacaa, ui a iaio a?oiao oai?eo niinoa??aaeeny iniaeeaino? ia?aa?ao caoai?thaaiue ia i?aenoaa? aeieia?/iiai i?aneiao. Ia oeueiio oii? ye a oiiaao ciai?oiueiai ii?ii?ithaaiiy, oae ? a oiiaao ae?? aaaeeeo iaoae?a ia? i?noea ni?euei?noue iaoiaaiaoe/ieo iaoai?ci?a ?icaeoeo ii?ooaiue o?ce/ii? aeoeaiino? i?ia?aeueieo ?a/iaei e?ia? oa ?ioiiiai caoenoo. I?e oeueiio iineeththoueny ?iceaaee aaaaoaoeaii? oa oeaio?aeueii? ia?aiai? nenoaie, ye? noi?iaiaeaeothoueny ii?ooaiiyie nae?aoe?? oa ?aaaia?aoe?? oa i?ecaiaeyoue aei aa?aneaiino? aano?iaeoiaeaiaeueieo caoai?thaaiue. Oe? ianoaaeie coiiaeththoue ?ic?iaeo niiniao ei?aeoe?? i?ia?aeueiiai oa ?ioiiiai aeenaaeaino o oai?eo ?c iaoieia??th i?aai?a o?aaeaiiy a oiiaao aeieia?/iiai i?aneiao. I?eeiath/e aei oaaae aeai? e?oa?aoo?e oa aeanieo aeine?aeaeaiue, iaie ?ic?iaeaii iiaee niin?a ei?aeoe?? c aeei?enoaiiyi eiiieaeniio iaoae?a - ae?iao???ai? nie? aoeeaiae?ai?ioao?aioeoiai? eeneioe (o?eeiio A). Aiaeiaii ? ?ai?oa ?ic?iaeaiee iaie iaoiae canoinoaaiiy eiiieaeniio iaoae?a (A.N. 1600036 N?N?). Aeei?enoiaoaaany iaoiae oiiioi?aco o?eeiio A: o?eeii A o neeaae? 14%-i? iac? (iniiaa - eaiie?i, aacae?i ii??aio) aaiaeeany ca aeiiiiiaith oeueo?acaoeo c /anoioith oeueo?acaoeiaeo eieeaaiue 880 ±0,88 eAoe a ?iioeueniiio ?aaeei?, eo?n - 12 i?ioeaaeo?. Oiiioi?ac i?iaiaeeany i?ney i?eeiyooy ??aeeie. Ca?aeii c aeanieie aeine?aeaeaiiyie, ye o oai?eo a oiiaao aeieia?/iiai i?aneiao, oae ? o oai?eo i?ae /an ia?aaeiia?aoe?eii? OAO niinoa??aaeeny iaeiini?yiiaai? ci?ie i?ia?aeueiiai oa ?ioiiiai aaeaino. Ia oe?e i?aenoaa? iaie i?iaaaeaii ai?iaaoe?th ?ic?iaeaiiai niiniao ei?aeoe?? o oai?eo, ui io?eioaaee i?iiaiaao oa?ai?th, c aeei?enoaiiyi ae?oai? iiaeeo?eaoe?? oaaaeaiiy o?eeiio A. I?eeiath/e aei oaaae iaiaaeai?noue canoinoaaiiy o?c?ioa?ai?? iieieia?/iei oai?ei, iaie aeei?enoiaoaaany aie?eaoe?eiee iaoiae. Aie?eaoe?? c 14%-ith iaccth o?eeiio A (iniiaa - eaiie?i, aacae?i ii??aio) c 33%-ei aiaeiei ?ic/eiii aeeiaeneaeo noaaeeeny /a?ac aeaiue ia 7 - 8 aiaeei (ia i?/) ia?aae naainii OAO, eo?n - 12 i?ioeaaeo?. Aeey ioe?iee aoaeoeaiino? ?ic?iaeaiiai niiniao ei?aeoe?? an?o oai?eo aoei ?iciiae?eaii ia aea? i?aea?oie: A - oai??, ye? io?eioaaee o?aaeeoe?eia eiiieaenia e?eoaaiiy (aac ei?aeoe??); A - oai??, ye? ia oii? eiiieaenii? oa?ai?? aeiaeaoeiai io?eioaaee ?ic?iaeaiee niin?a ei?aeoe?? (c ei?aeoe??th). Aiae?c aieeao eiiieaenii? oa?ai?? c aeeth/aiiyi o?eeiio A i?iaiaeeany ca oaeeie e?eoa??yie: aeeiai?ea ee?i?/ieo i?iya?a caoai?thaaiiy; ci?ie i?ia?aeueiiai aaeaino e?ia?; aeeiai?ea ?ioiieia?/ieo iieaciee?a. Aaciaa e?eoaaiiy aano?iaeoiaeaiaeueii? iaoieia?? neeaaeaei: aeieaoi?e I2-?aoeaioi??a, i-oie?iie?oeee, aioaoeeaee, oeeoii?ioaeoi?e, caniae ii?iae?caoe?? iioi?ii? ooieoe?? oeoiea ? AeIE, ?aia?aioe, iio??eio oa?ai?th, ?ia?a?oi?e “i?ioiiii? iiiie”, o?c?ioa?ai?th. O a?oi? EIA i?aea?oio A neeaee 70 oai?eo, i?aea?oio A - 67 oai?eo. O i?ioean? aeeiai?/iiai niinoa?aaeaiiy ca oai?eie anoaiiaeaii, ui ia oii? oa?ai??, yea i?iaiaeeeany a iaio i?aea?oiao, iie?auoaaeiny caaaeueia naiiii/oooy, ianoaaaea ?aa?an?y ee?i?/ieo i?iya?a caoai?thaaiiy. Canoinoaaiiy ?ic?iaeaiiai niiniao ei?aeoe?? o oai?eo i?aea?oie A ni?eyei ?noioiei ci?iai, ui aeiaaaeaii noaoenoe/iei aiae?cii ca iaoiaeii eooiaiai ia?aoai?aiiy O?oa?a. I?e ii??aiyii? iaio i?aea?oi aecia/aeiny ciaioaiiy /anoioe aeeniaioe/ieo ?iceaae?a (?j=0,054 - aeainoi?iii?e e?eoa??e), aieueiaiai neiae?iio (?j=0,091 - aeainoi?iii?e e?eoa??e), anoaii-aaaaoaoeaieo ?iceaae?a (?j=0,002 - aeainoi?iii?e e?eoa??e). I?iaaaeaiiy e?eoaaiiy noi?iaiaeaeoaaeiny ci?iaie a i?ia?aeueiiio aaeain? e?ia? e?ea?aeaoi??a. A iaio i?aea?oiao aecia/aeany oaiaeaioe?y aei ii?iae?caoe?? o?ce/ii? aeoeaiino? iae?i- ? i?e?iaeaiaio?a, ui caaacia/eei ii?iae?caoe?th eiao?oe??io?a ni?aa?aeiioaiiy aeayeeo i?ia?ae?a. O oai?eo i?aea?oie A e?ioeaa? iieacieee ??aiy aeoeaiino? eaeueoe?th, ia?aaioeth, oeoaio, aaiaae?th, aa?iai?th i?aeoe/ii aeinyaee iieaciee?a aeiii??a, eieeaaiiy i?e?a a??ia?aeii neeaee aei 6,0%. Anoaiiaeaii aoaeoeai?noue ?ic?iaeaiiai niiniao ei?aeoe?? ia i?aenoaa? a??ia?aeii? ??cieoe? ci?i iieaciee?a a?eueoino? i?ia?ae?a i?ae aeaiia i?aea?oiaie: iaai?th, e?aii?th, n??ee, eae?th, eaeueoe?th (?j<0,001 - aeainoi?iii?e e?eoa??e); eiaaeueoo (?j=0,044 - aeainoi?iii?e e?eoa??e); naeaio (?j=0,005 - aeainoi?iii?e e?eoa??e); oeoaio, aaiaae?th, ia?aaioeth, cae?ca, i?eaeth, i?ae?, oeeieo, aa?iai?th, no?iioe?th, ?o??th (?j<0,001 - aeainoi?iii?e e?eoa??e). Aeai? ??cieoe? ci?i o?ce/ii? aeoeaiino? iao??th, aethi?i?th, oinoi?o, oei?o ia aoee a??ia?aeieie. Uiaei noaio ?ioi?oaoo, oi i?ney e?eoaaiiy a iaio i?aea?oiao aecia/aeany iiceoeaia aeeiai?ea iieaciee?a ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo. Ci?ie iieaciee?a ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo a i?aea?oi? A aoee a?eueo ?noioi?. Iaeneiaeueii iaaeeceeeny aei ii?ie oae? iieacieee: aaniethoia e?euee?noue A-?OE, ND3+, I-ee?oei, OO*-?OE, ND4+, ??aaiue ??? ND4/ND8, Oe?E, aeai? a??ia?aei?. Aoaeoeai?noue eiiieaeniiai e?eoaaiiy aano?iaeoiaeaiaeueii? iaoieia?? o e?ea?aeaoi??a c aeei?enoaiiyi oiiioi?aco o?eeiio A aeiaaaeaia ia i?aenoaa? ??cieoe? ci?i a?eueoino? iieaciee?a ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo a i?aea?oiao A oa A. Oae, ca?eueoeany ??aaiue O-e?ioioeeo?a - A-?OE (?j<0,001 - aeainoi?iii?e e?eoa??e), ND3+ (?j=0,014 - aeainoi?iii?e e?eoa??e); c?inea aaniethoia e?euee?noue OO?-?OE ? ND4+ (?j<0,001 - aeainoi?iii?e e?eoa??e), ui ni?eyei ii?iae?caoe?? ??? OO?/OO* (?j<0,001 - aeainoi?iii?e e?eoa??e), ND4/ND8 (?j=0,26 - aeainoi?iii?e e?eoa??e); iaaeeceeany aei ii?ie aaniethoia e?euee?noue “iaiiaieo” ?icaoie (?j=0,047 - aeainoi?iii?e e?eoa??e), aaaaoi?aoeaioi?ieo ?OE ? Aaeo-?OE (?j<0,001 - aeainoi?iii?e e?eoa??e), aooi-?OE (?j<0,005 - aeainoi?iii?e e?eoa??e); ciaioeany ??aaiue Oe?E (?j=0,045 - aeainoi?iii?e e?eoa??e), cie?aia ae??aiiiieaeoey?ieo ? na?aaeiueiiieaeoey?ieo; ii?iae?coaaeany ooieoe?iiaeueia aeoeai?noue O-ee?oei - c??n I? o ?AIE c: OA (?j=0,037 - aeainoi?iii?e e?eoa??e), AeIEA (?j=0,047 - aeainoi?iii?e e?eoa??e), EIE (?j=0,030 - aeainoi?iii?e e?eoa??e). Ci?ie AAN-?OE, I-ee?oei, N-?OE, A*-?OE, ND8+, ND22+, Ig A, M, G ia aoee a??ia?aeieie. O a?oi? ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa i?aea?oio A neeaee 70 oai?eo, i?aea?oio A - 69 oai?eo. I?iaaaeaiiy e?eoaaiiy a iaio i?aea?oiao noi?iaiaeaeoaaeiny iiceoeaiith aeeiai?eith. Niinoa??aaeiny ciaioaiiy /anoioe aeeniaioe/iiai (pj =0,109 - aeainoi?iii?e e?eoa??e) ? aieueiaiai (p j =0,107 - aeainoi?iii?e e?eoa??e) neiae?ii?a, ciaioeeeny iaa?ioe/i? ?iceaaee (pj=0,08 - aeainoi?iii?e e?eoa??e), i?ioa ??cieoe? ci?i i?ae iaiia i?aea?oiaie aoee ia a??ia?aeieie. I?ney e?eoaaiiy a iaio i?aea?oiao oai?eo iaee i?noea ci?ie a o?ce/i?e aeoeaiino? iae?i- oa i?e?iaeaiaio?a oe?eueii? e?ia?. Aiaeia?/ii, ye ? na?aae EIA, o ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa ?a?no?oaaeiny ciaioaiiy i?e?a aeoeaiino? i?ia?ae?a. I?e oeueiio o i?aea?oi? A ci?ie aeoeaiino? i?ia?ae?a o ii??aiyii? c ii/aoeiaeie aoee a?eueo ?noioi?. E?ioeaa? iieacieee ??aiy iaai?th, eaeueoe?th, oeoaio, oeeieo, aa?iai?th, a?iio a?ae??ciyeeny a?ae eiio?ieueii? a?oie ia a?eueoa, i?ae ia 10,0%, a ??ai? naeaio oa ?o??th aeinyaee ??aiy aeiii??a, aeai? a??ia?aei?. Ia??aiii??i?noue nooiaiy ci?i aeoeaiino? i?ia?ae?a caaacia/eea a??ia?aeio ii?iae?caoe?th eiao?oe??io?a ni?aa?aeiioaiiy iaai?th aei eaeueoe?th, eaeueoe?th aei oinoi?o, iao??th aei eae?th, i?ae? aei oeeieo, iao??th aei aaiaae?th, n??ee aei i?ae?. Iaeaeua aoaeoeai?noue o e?eoaaii? oai?eo iia'ycaia c aeei?enoaiiyi oiiioi?aco o?eeiio A, ui aoei aeiaaaeaii noaoenoe/ii ca?aeii c aeainoi?iii?i e?eoa???i O?oa?a ca aeaieie ??cieoe? ci?i i?ae iaiia i?aea?oiaie i?e?a aeoeaiino? aethi?i?th (?j=0,043); eae?th (?j=0,045); eaeueoe?th (?j=0,002); oeoaio, ia?aaioeth, cae?ca, i?eaeth, i?ae?, oeeieo, naeaio, a?iio, ieo'yeo (?j<0,001); aaiaae?th (?j=0,006); aae?th (?j=0,026); aa?iai?th (?j=0,005); no?iioe?th (?j=0,027); ?o??th (?j=0,004). Eeoa ??cieoe? ci?i iieaciee?a iao??th, iaai?th, e?aii?th, oinoi?o, n??ee, oei?o ia aoee a??ia?aeieie. I?iaaaeaia oa?ai?y ni?aaeyea ae?th ia ee?oeiio oa aoii?aeueio eaiee ?ioi?oaoo a i?aea?oi? A ? a i?aea?oi? A. sse na?aae e?ea?aeaoi??a, oae ? na?aae ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa niinoa??aaeiny iie?auaiiy ?ioiieo iieaciee?a. ?a?no?oaaeiny cia/ia iaaeeaeaiiy e?ioeaaeo ?ioiieo iieaciee?a o i?aea?oi? A aei ii?ie, cie?aia aaniethoii? e?eueeino? A-?OE, ND3+, OO?-?OE, ND4+, ??aiy ??? OO?/OO*, a ??? ND4/ND8 c??aiyany c ii?iith. Aeiaaaeaii aoaeoeai?noue ?ic?iaeaiiai niiniao ei?aeoe?? ca aeainoi?iii?i e?eoa???i i?e c?noaaeaii? ?ioiieo iieaciee?a iaio i?aea?oi, a naia: aaniethoii? e?eueeino? A-?OE (?j=0,043), AAN-?OE (?j=0,003), aaaaoi?aoeaioi?ieo ?OE (?j=0,026), Aaeo-?OE (?j<0,001), OO?-?OE (?j=0,012) ? ND4+ (?j<0,001), ??? OO?/OO* (?j<0,01) ? ND4/ND8 (?j<0,001), I-ee?oei (?j=0,038), A*-?OE (?j<0,001), ??aiy Oe?E (?j=0,05). Oaeiae ?noioii c?inea ooieoe?iiaeueia aeoeai?noue O-ee?oei ca?aeii c aeaieie ?AIE. Ci?ie aaniethoii? e?eueeino? OO*-?OE, “iaiiaieo” ?icaoie, N-?OE, aooi-?OE, ND3+, ND8+, ND22+ ia aoee a??ia?aeieie. Oaeei /eiii, canoinoaaiiy ?ic?iaeaiiai niiniao ei?aeoe?? c aeei?enoaiiyi oiiioi?aco o?eeiio A a oiiaao aeieia?/iiai i?aneiao ye na?aae EIA, oae ? na?aae ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa na?ae/eoue i?i iiceoeaio aeeiai?eo ee?i?/ieo i?iya?a a?iceaii-ae?aceiaeo o?aaeaiue aano?iaeoiaeaiaeueii? ciie ia oii? e?ea?aeoaaiiy i?ia?aeueiiai aeenaaeaino e ii?iae?caoe?? noaio ee?oeiiiai oa aoii?aeueiiai ?ioi?oaoo, i?e/eiii coiiaeaieo ae??th aa?aneaieo /eiiee?a aaa??? ia *AAN, cie?aia ?aae?aoe?eiiai, i?iieneiaiai. A?oio ai?iaaoe?? aoei oaeiae ?iciiae?eaii ia aea? i?aea?oie: A - 71 oai?eo, ui io?eioaaee OAO o eiiieaen? c o?aaeeoe?eiei e?eoaaiiyi; A - 68 oai?eo, ye? io?eioaaee OAO o eiiieaen? c ?ic?iaeaiei niiniaii ei?aeoe??. O?aaeeoe?eia e?eoaaiiy ia oii? i?iiaiaai? oa?ai?? aeeth/aei aeac?ioieneeaoe?ei? caniae, a?oai?iioa?ai?th, e?eoaaiiy oe??yieo ooeiaeaeaiue. I?iaaaeaiiy aie?eaoe?eiiai oaaaeaiiy o?eeiio A c aeeiaeneaeii iieieia?/iei oai?ei i?ae /an ia?aaeiia?aoe?eii? OAO ni?eyei ciaioaiith ?icaeoeo neiae?iio i?iiaiaaeo ?aaeoe?e, a i?e iayaiino? eiai - ciaioaiith ?ioaineaiino? ee?i?/ieo i?iya?a, ui niinoa??aaeiny o i?aea?oi? A. I?ney e?eoaaiiy ?a?no?oaaeiny cieaeaiiy e?eueeino? oai?eo c anoaii-iaa?ioe/ieie ?iceaaeaie (?j<0,001 - aeainoi?iii?e e?eoa??e), oe??yieie ?aaeoe?yie (?j<0,001 - aeainoi?iii?e e?eoa??e), aaiaoieia?/ieie c?ooaiiyie, cie?aia eaeeiiai??th ? e?ioiiai??th (a?aeiia?aeii: ?j=0,004, ?j<0,001 - aeainoi?iii?e e?eoa??e), oaiia?aoo?iith ? eaoa?aeueiith ?aaeoe?yie (?j=0,016 aeey iaio iieaciee?a - aeainoi?iii?e e?eoa??e), ui i?aeoaa?aeaeoaaei aoaeoeai?noue ?ic?iaeaiiai niiniao ei?aeoe??. Ci?ie /anoioe aeeniaioe/iiai oa e?noeiai-noaeiaiaiai neiae?ii?a ia aoee a??ia?aeieie. Canoinoaaiiy ?ic?iaeaiiai niiniao ei?aeoe?? ia oii? ia?aaeiia?aoe?eii? OAO noi?iaiaeaeoaaeiny iiceoeaieie ci?iaie a i?ia?aeueiiio aaeain? oe?eueii? e?ia?. I?e oeueiio e?ioeaa? iieacieee ??aiy o?ce/ii? aeoeaiino? i?ia?ae?a o i?aea?oi? A ?noioii a?ae??ciyeeny a?ae iieaciee?a i?aea?oie A e iaaeeaeaeeny caeaa?eueoiai aei ii/aoeiaiai ??aiy, a ?iiae? - aei ??aiy aeiii??a. Oaeiae a??ia?aeii ii?iae?coaaeeny eiao?oe??ioe ni?aa?aeiioaiiy aeoeaiino? iaai?th aei eaeueoe?th, eaeueoe?th aei oinoi?o, i?ae? aei oeeieo, iao??th aei aaiaae?th, ??aaiue yeeo i?aeoe/ii aeinyaioa iieaciee?a eiio?ieueii? a?oie. Anoaiiaeaii aoaeoeai?noue aie?eaoe?eiiai oaaaeaiiy o?eeiio A c aeeiaeneaeii i?ae /an i?iaaaeaiiy ia?aaeiia?aoe?eii? OAO iieieia?/iei oai?ei ia i?aenoaa? ??cieoe? ci?i aeoeaiino? i?ia?ae?a e?ia? iaio i?aea?oi: iaai?th, aethi?i?th, e?aii?th, oinoi?o, n??ee, eae?th (?j<0,001 - aeainoi?iii?e e?eoa??e), eaeueoe?th (?j=0,029 - aeainoi?iii?e e?eoa??e), oeoaio, aaiaae?th, o?iio, ia?aaioeth, cae?ca, eiaaeueoo, i?ae?, aae?th, aa?iai?th, ieo'yeo, naeaio, a?iio, no?iioe?th, ?o??th (?j<0001 - aeainoi?iii?e e?eoa??e). Eeoa ci?ie iao??th, oei?o, i?eaeth, oeeieo ia aoee a??ia?aeieie. Iaeii/anii ei?eaoth/a oa?ai?y iaea aieea ? ia noai ?ioi?oaoo. O i?aea?oi? A e?ioeaa? iieacieee ye ee?oeiiiai, oae ? aoii?aeueiiai ?ioi?oaoo aoee cia/ii e?aueie ca iieacieee a i?aea?oi? A. E??i oiai, aiie iaei a?ae??ciyeeny a?ae ii/aoeiaeo, a aeaye? iaaeeaeaeeny aei ii?ie. Aeiaaaeaii aoaeoeai?noue aeei?enoaiiy ?ic?iaeaiiai niiniao ei?aeoe?? oai?ei i?ae /an i?iiaiaai? oa?ai?? ia i?aenoaa? ??cieoe? ci?i iieaciee?a ee?oeiiiai e aoii?aeueiiai ?ioi?oaoo i?ae aeaiia i?aea?oiaie ca aeainoi?iii?i e?eoa???i, a naia: aaniethoii? e?eueeino? A-?OE, ND3+; OO*-?OE, ND8+; aaaaoi?aoeaioi?ieo ?OE, “iaiiaieo” ?icaoie, Aaeo-?OE, aooi-?OE, OO?-?OE, AAN-?OE (?j<0,001); ND22+ (?j=0,017); A*-?OE (?j=0,037); ??aiy Ig A (?j=0,011); Ig M (?j=0,041); Oe?E (?j=0,027). Aeai? i?i ci?ie I-ee?oei, N-?OE, ND4+, ??? OO?/OO* ? ND4/ND8, aioo??oiueioe??yii? i?iae c OAA, Ig G ia aoee a??ia?aeieie. Oaeei /eiii, aie?eaoe?eiee niin?a oaaaeaiiy o?eeiio A c aeeiaeneaeii iieieia?/iei oai?ei, ye? io?eioaaee ia?aaeiia?aoe?eio OAO, ni?aaey? ye ?aae?ii?ioaeoi?io ae?th, oae ? e?eoaaeueio, ui aeyaey?oueny a ei?eaoaaii? ee?i?/ieo i?iya?a neiae?iio i?iiaiaaeo ?aaeoe?e, a oaeiae o noaa?e?coaaii?, a ?iiae? e ii?iae?caoe?? i?ia?aeueiiai oa ?ioiiiai aeenaaeaino e?ia?. Aeaiee niin?a aeciaii aeiaoiaeii (Iao. 17418A Oe?a?ia). ?acoeueoaoe aeine?aeaeaiue o?ueio a?oi oai?eo aeaee iiaeeea?noue aeciaoe, ui aeieia?/iee i?aneia, cie?aia ae?y ciai?oiueiai ii?ii?ithaaiiy, aaaeeeo iaoae?a oa eieaeueiiai ii?ii?ithaaiiy, noi?iaiaeaeo?oueny ii?aeiaiei ?icaeoeii i?ia?aeueiiai oa ?ioiiiai aeenaaeaino. Ia oe?e i?aenoaa? ?ic?iaeaii oa canoiniaaii i?ea?iaeueiee niin?a ei?aeoe?? aeyaeaieo ii?ooaiue. Ii??aiyeueiee aiae?c e?eoaaiiy ca o?aaeeoe?eiei oa ?ic?iaeaiei niiniaii cana?ae/ea aoaeoeai?noue niiniao ei?aeoe??. AENIIAEE 1. Naie??/iee iii?oi?eia oai?eo a oiiaao aeieia?/iiai i?aneiao (i?e?iee?iaoo c o?eaaeith aeniiceoe??th aaaeeeo iaoae?a ? ?aae?aoe?eiith ae??th) aeyaea cia/io iioe?ai?noue caoai?thaaiue i?aai?a o?aaeaiiy, eio?a ia?aaeuoaaea iaeaniee iieaciee na?aae EIA ia *AAN a 3,9 ?aca; na?aae ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa - a 2,6 ?aca. 2. O EIA a?iceaii-ae?aceia? o?aaeaiiy aano?iaeoiaeaiaeueii? ciie i?io?eaee ia oii? ci?iaii? iai?oanoiino? c i?aaaethaaiiyi aeeniaioe/ieo ?iceaae?a iaae aieueiaith neiioiiaoeeith a ii?aeiaii? c anoaii-aaaaoaoeaiei neiae?iiii ? noiooiueith aaiaoia?e?a?iith iaoieia??th oa a?aecia/aeeny iiiaeeii?noth aeano?oeoeaieo i?iya?a i?e aeio?eiai?e eeneioiooai?thth/?e ooieoe?? oeoiea. 3. O ?ia?oiee?a, eiioaeooth/eo ?c aaaeeeie iaoaeaie, c iayai?noth o?ii?/iiai aano?iaeoiaeai?oo ? ae?aceiai? oai?iae AeIE caeiiii??ii aeii?ioaaa aeeniaioe/iee neiae?ii o ii?aeiaii? c iaa?ioe/ieie ?iceaaeaie i?e ?cieueiaaiino? aeano?oeoeaieo o?aaeaiue o o?aaiiio o?aeo? oa ineaaeaii? eeneioii?iaeoeoe??, iniaeeai a noeioeueiaaio oaco. 4. Ae?y aa?aneaiiai na?aaeiaeua noi?iaiaeaeo?oueny ?icaeoeii i?ia?aeueiiai aeenaaeaino, yeee aecia/aii iaoiaeii AAeA?, ca ?aooiie ia?aaaaeiiai iineeaiiy o?ce/ii? aeoeaiino? eae?th, eaeueoe?th, aaaeeeo iaoae?a, iniaeeai i?ae? o EIA ? cae?ca, aaiaae?th, i?eaeth o ?ia?oiee?a aeoioeyoi?iiai ae?iaieoeoaa i?e a?aeiiniiio cieaeaii? aeoeaiino? oeeieo, iao??th, iaai?th a iaio a?oiao, ui ciaeoei nai? a?aeia?aaeaiiy, cie?aia, o ci?iao oa?iaioii? aeoeaiino? c ianooiiith iaoaaie?/iith ?ioiiaeai?an??th. 5. Ci?ie ?ioiiiai aiiainoaco a oiiaao aeine?aeaeaiiai aeieia?/iiai i?aneiao oa?aeoa?ecothoueny iayai?noth aoi?eiii? ?ioiieia?/ii? iaaeinoaoiino? ii a?aeiiniiio noi?ani?iiio aa??aioo, ui noi?iaiaeaeo?oueny cieaeaiiyi ooieoe?iiaeueii? aeoeaiino? O-ee?oei ? c?inoaiiyi i?ioean?a aooinainea?e?caoe?? c i?aeaeuaiiyi Oe?E, a iniiaiiio na?aaeiuei- oa ae??aiiiieaeoey?ieo eiiieaen?a, ? cieaeaiiyi ?ioiiaeiaoe?i?a. 6. Anoaiiaeaii aca?iica'ycie ee?i?/ieo iniaeeainoae ia?aa?ao aano?iaeoiaeaiaeueii? iaoieia?? c ii?ooaiiyie i?ia?aeueiiai oa ?ioiiiai noaoono, a naia: i?yia ei?aeyoe?y i?ae eiao?oe??ioii ni?aa?aeiioaiiy O-oaeia?e/O-noi?ani?e ? ni?aa?aeiioaiiyi o?ce/ii? aeoeaiino? iae?i- aei i?e?iaeaiaio?a, a oaeiae i?ae ??aiai Oe?E ? ??aiai o?ce/ii? aeoeaiino? aaaeeeo iaoae?a (cae?ci, i?aeue); cai?ioia ei?aeyoe?y i?ae aaniethoiith e?euee?noth O-e?ioioeeo?a ? ??aiai o?ce/ii? aeoeaiino? aaaeeeo iaoae?a. 7. O oai?eo, ui caciaee eieaeueiiai ii?ii?iaiiy, aeyaeaia aeaci?aai?caoe?y a i?eao o?ce/ii? aeoeaiino?, aieiaiei /eiii, o niaeo?? i?e?iaeaiaio?a, a oaeiae ?ioiiaeai?aneaiee noai c iaeii/aniei i?eai?/aiiyi O- ? A-eaiee ee?oeiiiai ?ioi?oaoo oa aenieith aeoeai?noth aooi?ioiieo i?ioean?a. 8. Canoinoaaiiy ei?eaoth/i? oa?ai?? a in?a, ui caciaee ae?? aeieia?/ii iani?eyoeeaeo oaeoi??a, ni?eyei iiceoeai?e aeeiai?oe? iaoieia?/iiai i?ioeano, a oaeiae ii?iae?caoe?? o?ce/ii? aeoeaiino? iae?i- ? i?e?iaeaiaio?a e?ia?, ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo. 9. Aeei?enoaiiy aie?eaoe?eiiai oaaaeaiiy eiiieaeniio iaoae?a ?c aeeiaeneaeii o oai?eo ia oii? eieaeueiiai ii?ii?ithaaiiy ni?aaeyei ye ?aae?ii?ioaeoi?io, oae ? e?eoaaeueio ae?th, yea aeyaeyeany o ei?aeoe?? neiae?iio i?iiaiaaeo ?aaeoe?e oa noaa?e?caoe?? i?ia?aeueiiai oa ?ioiiiai aaeaino e?ia?. I?AEOE*I? ?AEIIAIAeAOe?? 1. Aeey ia'?eoeaii? ioe?iee aieeao aeieia?/iiai i?aneiao ia iaoieia?th i?aai?a o?aaeaiiy ?aeiiaiaeo?oueny a?aoiaoaaoe noai i?ia?aeueiiai aaeaino e?ia? oa ?ioii? iieacieee. 2. I?iiiio?oueny aeei?enoaiiy aia?ai-aeenia?n?eiiai ?aioaai?anueeiai aiae?co aeey ioe?iee ??aiy o?ce/ii? aeoeaiino? oe?ieiai niaeo?o i?ia?ae?a oe?eueii? e?ia?. 3. Aoaeoeai?noue e?eoaaiiy aano?iaeoiaeaiaeueieo caoai?thaaiue o EIA oa ?ia?oiee?a, eiioaeooth/eo ?c aaaeeeie iaoaeaie, iiaeeeaa i?e aeei?enoaii? a eiiieaen? oiiioi?aco o?eeiio A. 4. ?aeiiaiaeo?oueny niin?a ei?aeoe?? i?iiaiaaeo ?aaeoe?e oai?ei i?ae /an eieaeueiiai ii?ii?ithaaiiy ?c canoinoaaiiyi aie?eaoe?eiiai oaaaeaiiy o?eeiio A ?c aeeiaeneaeii. NIENIE I?AOeUe, IIOAE?EIAAIEO CA OAIITH AeENA?OAOe?? 1. Oeaea E.A. Ia?ooaiea iaoaaieecia i?e ni/aoaiee aee- aanoeaiie e aaiaoiaeeea?iie iaoieiaee o eeeaeaeaoi?ia iineaaenoaee aaa?ee ia *AYN // E?e. ni?aaa. - 1998. - ? 7. - N. 42 - 45. 2. Oeaea E.A. Iaoaaiee/aneea ia?ooaiey e eeeie/aneea i?iyaeaiey iaoieiaee aeeaanoeaiie nenoaiu o eeeaeaeaoi?ia iineaaenoaee aaa?ee ia *a?iiaueueneie AYN // Oe?.iaae.aeueiaiao. - 1998. - O. 1, ? 1. - N. 86 - 89. 3. Oeaea E.A. Iaoiaaiaoe/aneay acaeiinaycue aeecyeaeo?ieeoaiee, eiioiiiai aeenaaeaina n iaoiii?oieiae/aneeie eciaiaieyie aeeaanoeaiie nenoaiu a oneiaeyo yeieiae/aneiai i?anneiaa // Oe?.iaae.aeueiaiao.-1998. - O.1, ? 3. - N. 176 - 179. 4. Oeaea E.A. Ii??aiyeueia ioe?iea aoaeoeaiino? niiniao ei?aeoe?? i?iiaiaaeo ?aaeoe?e o iieioai?eo, io?eioth/eo oaeaaaiiaoa?ai?th // Oe?.iaae.aeueiaiao. - 1998.-O.1, ? 4. - N. 39 - 42. 5. Oeaea E.A. Eeeieei-eiioiieiae/aneea eciaiaiey i?e iaoieiaee aeeaanoeaiie nenoaiu o eeeaeaeaoi?ia iineaaenoaee aaa?ee ia *a?iiaueueneie AYN // Aanoi. i?iaeai aeie.iaae. - 1998. - Aui. 9. - N. 18 - 24. 6. Oeaea E.A. Ieia?aeueiue aeenaaeain i?e ycaaiiie aieac-ie aeaaiaaeoeaoeia?noiie eeoee o eeoe, ?aaioathueo a yeieiae/anee iaaeaaii?eyoiii i?iecaiaenoaa // A?ni. i?iaeai a?ie.iaae. - 1998. - Aei. 15. - N. 22 - 25. 7. Oeaea E.A. Iee?iyeaiaiou eae ia?ea?u eo/aauo iia?aaeaeaiee // A?ni. i?iaeai a?ie.iaae.-1998.-Aei.20. - N. 127 - 131. 8. Oeaea E.A. Ee?oeiiee ? aoii?aeueiee ?ioi?oao o oai?eo ?c aeeaanoeaiith iaoieia??th a oiiaao aeieia?/iiai i?aneiao // Oe?.iaae.aeueiaiao. - 1998. - O.1, ? 4. - N. 121 - 123. 9. Oeaea E.A. Aieea oaeoi??a aeoioeyoi?iiai ae?iaieoeoaa ia ?ioiio nenoaio i?e aeeaanoeai?e iaoieia?? // Oe?.iaae.aeueiaiao. - 1999. - O.2, ?1. - N. 151 - 153. 10. Oeaea E.A. Aeeyiea ?ac?aaioaiiiai niiniaa ea/aiey ia ieia?aeueiue aaeain e?iae i?e aeeaanoeaiie iaoieiaee o eeeaeaeaoi?ia iineaaenoaee aaa?ee ia *AYN // A?ni.i?iaeai a?ie.iaae. - 1999. - Aei. 6. - N. 60 - 62. 11. Oeaea E.A. Ia?ooaiey eeaoi/iiai e aoii?aeueiiai eioiieoaoa i?e eo/aaii aicaeaenoaee, e niinia ei??aeoeee // A?o.eeei.yeni.iaae. - 1999. - O.8, ?1. - N. 30 - 33. 12. Iao. 17418A Oe?a?ia, IE? A 61E 31/00, A 61 N 5/10. Niin?a ei?aeoe?? neiae?iio i?iiaiaaeo ?aaeoe?e i?ae /an i?iiaiaaiai ii?ii?iaiiy / E.A.Oeaea (Oe?a?ia). - ?95125332; Cayae. 18.12.95; Iioae. 31.10.97. Athe. ? 5. - 5n. 13. Oeaea E.A. Aeenoa?iaioaiey e aeecyeaeo?ieeoaiey i?e ii?aaeaiee aaiaoiaeeea?iie nenoaiu o eeeaeaeaoi?ia iineaaenoaee aaa?ee ia *a?iiaueueneie AYN // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca.iaoe.i?aoeue.-E.-Eoaainuee, 1996. - N. 215 - 217. 14. Aeia?ei A.TH., Oeaea E.A. N?aaieoaeueiay ioeaiea eiioiiiai noaoona o aieueiuo n ycaaiiie aieaciueth aeaaiaaeoeaoeia?noiie eeoee a oneiaeyo yeieiae/aneiai i?anneiaa // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca.iaoe.i?aoeue.-E.-Eoaainuee, 1998. - Aei.3. - N. 87 - 94. 15. Oeaea E.A. Ei??aeoeey iee?iyeaiaioiiai iaiaia o aieueiuo ?aeii iiei/iie aeaeacu ai a?aiy eo/aaie oa?aiee // I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y : Ca. iaoe. ?ia?o anioe?aoe?? ?aae?ieia?a Oe?a?ie.-E., 1998. - Aei.2. - N. 208 - 210. 16. Oeaea E.A. Eiioiiue aeenaaeain iiae aicaeaenoaeai ianoiiai iaeo/aiey o aieueiuo ni ceiea/anoaaiiuie iiaiia?aciaaieyie iiei/iie aeaeacu // Aeooaeuei? i?iaeaie aeooa?noaa ? a?iaeieia??, ee?i?/ii? ?ioiieia?? oa iaaee/ii? aaiaoeee: Ca.iaoe.i?aoeue. - E. - Eoaainuee, 1999. - Aei.3. - N.272 - 276. 17. Oeaea E.A. Niinia ei??aeoeee eiioiiiai aeenaaeaina o iieieiae/aneeo aieueiuo ai a?aiy eo/aaie oa?aiee // I?iaeaie aeieia?/ii? oa iaaee/ii? aaiaoeee ? ee?i?/ii? ?ioiieia??: Ca.iaoe. i?aoeue. - E. - Eoaainuee-Oa?e?a, 1999. - Aei. 3 (23). - N. 221-226. 18. Oeaea E.A. Ia?ooaiey ieia?aeueiiai ninoaaa e?iae i?e aicaeaenoaee ?aaeeaoeeiiiiai oaeoi?a // I?iiaiaaa ae?aaiinoeea, i?iiaiaaa oa?ai?y: Ca.iaoe.?ia?o anioe?aoe?? ?aae?ieia?a Oe?a?ie.-E., 1999.-Aei.5. - N. 139 - 144. 19. Oeaea E.A. Iniaeeaino? ee?i?/ieo i?iya?a aeeaanoeaii? iaoieia?? o e?ea?aeaoi??a iane?aee?a aaa??? ia *AAN // Aano?iaioa?ieia?y: I?aea?ae.ca.-Aei?i?iiao?ianuee, 1999.-Aei.28, i?enay/. 20-??//th eao.aano?iaioa?ieia?? Aei?i?iiao?ianuee.aea?ae.iaae.aeaaeai??.-N. 327 - 330. 20. Ia/ia Ae.N., Oeaea E.A. Neiae?ii i?iiaiaaeo ?aaeoe?e i?e oaeaaaiiaoa?ai?? o oai?eo ?aeii iiei/ii? caeice ? niin?a ei?aeoe?? // Ca.iaoe.i?aoeue ni?a?ia?oiee?a EIAII ?i. I.E.Ooieea. - E., 1998. - Aei. 7, ei. 2. - N. 127 - 133. 21. Oeaea E.A. Iiaee niin?a ei?aeoe?? iaoaaie?cio i?e?iaeaiaio?a o iieioai?eo i?ae /an i?iiaiaai? oa?ai?? // A?o. iieieia??. - 1996. - ? 1. - N. 70 - 71. 22. Oeaea E.A. Ee?oeiiee oa aoii?aeueiee ?ioieoao o iieioai?eo i?ae aieeaii oaeaaaiiaoa?ai?? // A?o. iieieia??. - 1996. - ? 1. - N. 117 - 118. 23. Oeaea E.A. Aeeiaieea iee?iyeaiaioia e?iae a i?ioeanna eo/aaie oa?aiee ?aea iiei/iie aeaeacu // Cae?aaiio?aiaiea Aeiiaanna. - 1997. - ? 1. - N. 50 - 52. 24. Ia/ia Ae.N., Aeia??i A.TH., Oeaea E.A. Aea/aiiy aieeao aeieia?/ii iani?yoeeaeo oaeoi??a ia iaoieia?th aeeaanoeaii? nenoaie (iaoeiaee iaeyae) // I?AE - ?.2: Nioe?aeueia iaaeeoeeia oa i?aai?caoe?y ioi?iie caei?ia'y. - 1997. - ? 3 - 4. - N. 22 - 29. 25. Oeaea E.A. Aeeniaoaaiee/aneea aniaeou aicaeaenoaey yeieiae/anee iaaeaaii?eyoiuo oaeoi?ia e iniaaiiinoe eeeie/aneeo i?iyaeaiee ii?aaeaiey aeeaanoeaiie nenoaiu // Iaaeeei-a?ieia?/i? i?iaeaie i?iieneiaiai ?aa?iio: Ca. iaoe. noaoae a/aieo Eoaainuee.aea?ae.iaae.oi-oo. - Eoaainuee, 1997. - Aei.1. - N. 197 -200. 26. Oeaea E.A. I?ia?aeuei? ?a/iaeie : a?ieia?/ia ?ieue oa ?o ci?ie i?e iaoieia?/iiio noai? ? i?ae aieeaii o?ce/ieo oa o?i?/ieo oaeoi??a (iaoeiaee iaeyae) // I?AE.-?. 1: Aioo??oi? oai?iae. - 1998. - ? 3 - 4. - N. 11 - 18. 27. Oeaea E.A. Ninoiyiea eiioiiie nenoaiu o aieueiuo ?aeii iiei/iie aeaeacu, iieo/athueo eo/aaoth oa?aieth // Iaoa?eaee thaee. iao/i.-i?aeo. eiio., iinayu. 100-eaoeth ni aeiy iniiaaiey 4-e ai?. a-oeu a. Eoaainea.-Eoaaine, 1995. - O.2. - N.34. 28. Ee?i?ei-?ioiieia?/i? neiae?iie ?aae?aoe?eii? iai?oae o in?a, i?aeiaaoeo i?ae caaaeueia oa i?noeaaa ii?ii?iaiiy / E.I.?aaiiaa, E.I.I?eaiei, O.I.*oeaiiaa, E.A.Oeaea // VI eiia?an na?oiai? oaaea?aoe?? oe?a?inueeeo e?ea?nueeeo oiaa?enoa 9-14 aa?aniy 1996?.: Oace aeii. - Iaeana, 1996. - N. 95. 29. Oeaea E.A. Iiaue iaoiae enneaaeiaaiey ieia?aeueiiai ninoaaa e?iae // Ca. iaoe. ?ia?o i'yoi? Anaoe?. ia?aaee c ieoaiue iie?ee?i?/ii? ni?aae 13-19 a?oaeiy 1996?.-Aei?i?iiao?ianuee, 1996.-N. 33. 30. Oeaea E.A. Aeenaaeain iee?iyeaiaioia i?e ianoiii iaeo/aiee // Ca. iaoe. ?ia?o i'yoi? Anaoe?. ia?aaee c ieoaiue iie?ee?i?/ii? ni?aae 13-19 a?oaeiy 1996?.-Aei?i?iiao?ianuee, 1996. - N. 33 - 34. 31. Oeaea E.A. Aeeiaieea o?iaiy iee?iyeaiaioia e?iae o eeoe, iiaeaa?aoeony ianoiiio e iauaio iaeo/aieth // Aiaoiyy n?aaea e caaieaaaiey aioo?aiieo i?aaiia : Na. ?aaio.-Eoaaine, 1997. - N. 48. 32. Oeaea E.A. Aeeyiea yeieiae/anee iaaeaaii?eyoiie ianoaiiaee ia eiioiiue noaoon eeeaeaeaoi?ia iineaaenoaee aaa?ee ia *AYN // A?a??i?/i? i?iaeaie ioi?iie caei?ia'y ianaeaiiy: Iaoa??aee tha?e. iaoe.-i?aeo. eiio., i?enay/. 75-??//th eao. a?a??ie ? aeieia?? ethaeeie.-Aei?i?iiao?ianuee, 1997. - N. 182 - 185. 33. Ei??aeoeey neiae?iia eo/aaiai iai?yaeaiey / E.A.Oeaea, A.TH.Aeia?ei, E.A.?iiaiaiei, E.I.Eaaiiaa, O.A.*oeaiiaa, E.A.I?eaiei // Internat. J. Immunorehabilitation.- 1997. - May, ?4.- ?. 75. Oeaea E.A. I?ia?aeueiee oa ?ioiiee aeenaaeain i?e aeeaanoeai?e iaoieia?? a oiiaao aeieia?/iiai i?aneiao ? niin?a ei?aeoe??. - ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.02 - aioo??oi? oai?iae. - Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea IIC Oe?a?ie, Ee?a, 1999. Aeena?oaoe?th i?enay/aii aea/aiith ee?i?/ieo iniaeeainoae aano?iaeoiaeaiaeueii? iaoieia?? a oiiaao ae?? ?aae?aoe?eiiai oaeoi?o ? aaaeeeo iaoae?a o aca?iica'yceo c? ci?iaie i?ia?aeueiiai aaeaino e?ia? oa ?ioiiiai noaoono, ye? ii?aeiai? i?ae niaith. Iaa?oioiaaii aeei?enoaiiy eiiieaeniio iaoae?a o oai?eo ?c iaoieia??th i?aai?a o?aaeaiiy a oiiaao aeieia?/iiai i?aneiao oa o oai?eo i?ae /an eieaeueiiai ii?ii?ithaaiiy, aeiaaaeaii aoaeoeai?noue niiniao ei?aeoe?? a onoiaii? i?ia?aeueiiai oa ?ioiiiai aeenaaeaino. Eeth/ia? neiaa: aano?iaeoiaeaiaeueia iaoieia?y, i?ia?aeueiee aaeain, ?ioiiee noaoon, aeieia?/iee i?aneia, eieaeueia ii?ii?ithaaiiy, ei?aeoe?y, aoaeoeai?noue. Shkala L.V. Iineral and immune disbalance under digestive pathology at the background of ecological pressing and the method of correction. - Manuscript. The dissertation for scientific degree of doctor of medical sciences on speciality - 14.01.02 - internal diseases. - Kyiv Medical Academy of Post-Graduated Education named after P. Shupyk Health Ministry of Ukraine, Kyiv, 1999. The dissertation is devoted to the study of clinical peculiarities of gastroduodenal pathology under the influence of radiation factor and heavy metals in the interconnection with changes of mineral blood balance and immune status which are combined with each other. The use of metal complexon to patients with digestive pathology under ecological pressing and to patients during local irradiation is grounded, efficiency of correction method in elimination of mineral and immune disbalance is justified. Key words: gastroduodenal pathology, mineral balance, immune status, ecological pressing, local irradiation, correction, efficiency. Oeaea E.A. Ieia?aeueiue e eiioiiue aeenaaeain i?e aeeaanoeaiie iaoieiaee a oneiaeyo yeieiae/aneiai i?anneiaa e niinia ei??aeoeee.-?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.02 - aioo?aiiea aieacie. - Eeaaneay iaaeeoeeineay aeaaeaiey iineaaeeieiiiiai ia?aciaaiey ei. I.E. Ooieea IC Oe?aeiu, Eeaa, 1999. Aeenna?oaoeey iniiaaia ia eeeie/aneii iaaethaeaiee e ianeaaeiaaiee 415 aieueiuo, ec ieo: 137 - EIA ia *AYN, iiaeaa?aoeony aiaoiaio iaeo/aieth; 139 - ?aai/eo i?iecaiaenoaa uaei/iuo aeeoioeyoi?ia, eiioaeoe?othueo n oyaeaeuie iaoaeeaie; 139 - aieueiuo, iiaeaa?aoeony eieaeueiiio iaeo/aieth. Eco/aiu eeeie/aneea iniaaiiinoe aano?iaeoiaeaiaeueiie iaoieiaee a oneiaeyo yeieiae/aneiai i?anneiaa, caeeth/athueany a aeiieie?iaaiee aeeniaioe/aneeo ?anno?ienoa i?e iaau?aaeaiiinoe aieaaie neiioiiaoeee ia oiia anoaii-aaaaoaoeaiiai neiae?iia o eeoe, iiaeaa?aoeony aiaoiaio ?aaeeaoeeiiiiio aicaeaenoaeth, e iaa?ioe/aneeo ?anno?ienoa o eeoe, aeeeoaeueii eiioaeoe?othueo n oyaeaeuie iaoaeeaie. I?e yoii ioia/aii i?aiaeaaeaiea aeano?oeoeaiuo ii?aaeaiee neecenoie aeaeoaeea e AeIE, a /anoiinoe, iiiaeanoaaiiiai oa?aeoa?a ia oiia i?aaaee?iaaiey nio?aiaiiie eeneioiia?acothuae ooieoeee aeaeoaeea o EIA, e eciee?iaaiiiai oa?aeoa?a i?e nieaeaiee eeneioii?iaeoeoeee, iniaaiii a noeioee?iaaiioth oaco, o ?aai/eo aeeoioeyoi?iiai i?iecaiaenoaa. E?iia oiai, yeieiae/aneee i?anneia iaoneiaeeaaao ni/aoaiea ii?aaeaiee aeaeoaeea e AeIE n aaiaoiaeeea?iuie caaieaaaieyie. Ii aeaiiui i?iaaaeaiiuo enneaaeiaaiee, aicaeaenoaea ?aaeeaoeeiiiiai e i?iiuoeaiiiai oaeoi?ia o aieueiuo n aano?iaeoiaeaiaeueiuie ii?aaeaieyie naycaii n ?acaeoeai ieia?aeueiiai e eiioiiiai aeenaaeaina. Enneaaeiaaiea iaee/ey e oece/aneie aeoeaiinoe ieia?aeueiuo aauanoa e?iae i?iaiaeeeinue n iiiiuueth ?aiaa ia i?eiaiyaoaainy a iaaeeoeeia iaoiaea yia?ai-aeenia?neiiiiiai ?aioaaiianeiai aiaeeca ia ?ano?iaii yeaeo?iiiii iee?ineiia ?YI-101 n yia?ai-aeenia?neiiiui ?aioaaiianeei aiaeecaoi?ii. Ieia?aeueiue aeenaaeain ii?aaeaeyeny ii eciaiaieth oece/aneie aeoeaiinoe ioaeaeueiuo ieia?aeia, a oaeaea ii ia?ooaieth niioiioaiey aeoeaiinoe eae n?aaee iae?i- e iee?iaeaiaioia, oae e iaaeaeo ieie. Auyaeaii i?aiaeaaeaiea o?iaiy aeoeaiinoe eaeey, eaeueoeey e oyaeaeuo iaoaeeia, iniaaiii iaaee o EIA e aeaeaca, aaiaaeey, ieeaey o ?aai/eo i?iecaiaenoaa uaei/iuo aeeoioeyoi?ia. Iaeiia?aiaiii ?aaeno?e?iaaeinue ioiineoaeueiia nieaeaiea o?iaiy aeoeaiinoe oeeiea, iao?ey, iaaiey. Ia?ooaiey eiioiiiai noaoona a oneiaeyo yeieiae/aneiai i?anneiaa auee naycaiu n iaee/eai O-eeioiiaiee n iiaeaaeaieai ooieoeeiiaeueiie aeoeaiinoe, O-noaiiioeyoeeiiiiai aeenaaeaina ii ioiineoaeueiiio noi?anni?iiio aa?eaioo ia?yaeo n aeoeaaoeeae i?ioeannia aooinaineaeeecaoeee. Onoaiiaeaia acaeiinaycue ia?ooaiee eiioiiiai e ieia?aeueiiai aaeaina e?iae ia i?eia?a niioiioaiey aaniethoiiai eiee/anoaa O-eeioioeeoia (CD3+) e oece/aneie aeoeaiinoe iaaee, aeaeaca; o?iaiy OeEE e aeoeaiinoe oeacaiiuo iaoaeeia, a oaeaea eiioii?aaoeyoi?iiai eiaeaena (CD4/CD8) e niioiioaiey aeoeaiinoe iae?i- e iee?iyeaiaioia. Aicaeaenoaea eieaeueiiai iaeo/aiey o aieueiuo nii?iaiaeaeaaony eciaiaieyie oece/aneie aeoeaiinoe ieia?aeueiuo aauanoa, iniaaiii a niaeo?a iee?iyeaiaioia, e eiioiiaeai?anneaiui ninoiyieai n iiaeaaeaieai O- e A-caaia eeaoi/iiai eiioieoaoa i?e aunieii o?iaia aooieiioiiuo i?ioeannia. Ia iniiaaiee aiaeeca auyaeaiiuo eciaiaiee o eeoe n y?iceaii-ycaaiiuie ii?aaeaieyie aeaeoaeea e AeIE, iiaeaa?aoeony yeieiae/aneiio i?anneiao, e aieueiuo, iiaeaa?aoeony eieaeueiiio iaeo/aieth, ?ac?aaioai iiaue niinia ei??aeoeee n eniieueciaaieai eiiieaeniia iaoaeeia. Aeieacaia yooaeoeaiinoue ?ac?aaioaiiiai niiniaa ea/aiey i?e eeeie/aneii iaaethaeaiee aieueiuo e i?e noaoenoe/aneii aiaeeca ?acoeueoaoia i?iaaaeaiiuo enneaaeiaaiee eae a ioiioaiee aeeiaieee iaoieiae/aneiai i?ioeanna, oae e a ioiioaiee ei??aeoeee ieia?aeueiiai e eiioiiiai aeenaaeaina. Eeth/aaua neiaa: aano?iaeoiaeaiaeueiay iaoieiaey, ieia?aeueiue aaeain, eiioiiue noaoon, yeieiae/aneee i?anneia, eieaeueiia iaeo/aiea, ei??aeoeey, yooaeoeaiinoue.

Добавить комментарий

Ваш e-mail не будет опубликован. Обязательные поля помечены *