Механізми розвитку захворювань печінки і нирок у гірників глибоких вугільних шахт Донбасу та можливі шляхи їх профілактики: Автореф. дис… д-ра мед.

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?nEoao

?AA?IA AI?EN IEAEN?EIAE*

OAeE 616.12-008-24-63:622.012.2-07.2-477.61/.62

IAOAI?CIE ?ICAEOEO CAOAI?THAAIUe IA*?IEE ? IE?IE

O A??IEE?A AEEAIEEO AOA?EUeIEO OAOO

AeIIAANO OA IIAEEEA? OEssOE ?O I?IO?EAEOEEE

14.01.02 — aioo??oi? oai?iae

Aaoi?aoa?ao

aeena?oaoe?? ia caeiaoooy iaoeiaiai nooiaiy

aeieoi?a iaaee/ieo iaoe

Oa?e?a — 1999

16

Aeena?oaoe??th ? ?oeiien

?iaioa aeeiiaia a Eoaainueeiio aea?aeaiiio iaaee/iiio oi?aa?neoao? IIC
Oe?a?ie

Iaoeiaee eiinoeueoaio:

aeieoi? iaaee/ieo iaoe, caneoaeaiee ae?y/ iaoee ? oaoi?ee Oe?a?ie,
i?ioani? Ieioe?i Aieiaeeie? sseiae/,

Eoaainueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe

Io?oe?ei? iiiiaioe:

aeaaeai?e AII, /eai-ei?aniiiaeaio IAI Oe?a?ie, caneoaeaiee ae?y/ iaoee ?
oaoi?ee Oe?a?ie, aeieoi? iaaee/ieo iaoe, i?ioani?

Ie??a Ethaiie? Aioiiiae/;

Ee?anueea iaaee/ia aeaaeai?y i?neyaeeieiiii? ina?oe ?i. I.E. Ooieea,
caa?aeoaa/ eaoaae?e iao?ieia??

aeieoi? iaaee/ieo iaoe, i?ioani?

Nai?aeioeueea AEaiia Aeieo???aia

Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, caa?aeoaa/ eaoaae?e
i?iiaaeaaoeee aioo??oi?o oai?ia ?2

aeieoi? iaaee/ieo iaoe

Aoaa?a??oe Iaoaey Ai?en?aia

Aeiiaoeueeee aea?aeaaiee iaaee/iee oi?aa?neoao, i?ioani? eaoaae?e
aioo??oi?o oai?ia ? 1

I?ia?aeia onoaiiaa: Iaoe?iiaeueiee iaaee/iee oi?aa?neoao ?i. aeaae.
I.I.Aiaiiieueoey, IIC Oe?a?ie

Caoeno a?aeaoaeaoueny 24 ethoiai1999 ?. i 9 aiaeei? ia can?aeaii?
niaoe?ae?ciaaii? a/aii? ?aaee Ae 64.600.04 i?e Oa?e?anueeiio
aea?aeaaiiio iaaee/iiio oi?aa?neoao? (310022, i. Oa?e?a, i?. Eai?ia, 4).

C aeena?oaoe??th iiaeia iciaeiieoeny o a?ae?ioaoe? Oa?e?anueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo (310022, i. Oa?e?a, i?. Eai?ia, 4).

Aaoi?aoa?ao ?ic?neaiee 12 n?/iy 1999 ?.

A/aiee nae?aoa?

niaoe?ae?ciaaii? a/aii? ?aaee

e. i. i., aeioeaio E.?. Ia/a?aieiCAAAEUeIA OA?AEOA?ENOEEA ?IAIOE

Aeooaeuei?noue oaie. ?icaeoie a??ie/i?oaeii? i?iieneiaino? Aeiiaano ia
no/aniiio aoai? oa?aeoa?eco?oueny aacia?a?aiei iia??oaiiyi oiia i?aoe?
i?aecaiieo a??iee?a aoa?eueieo oaoo [A.I.Eiaaoe, 1995; E.E.*a?eania,
1998]. C oeei iia’ycaii ca?eueoaiiy caoai?thaaiino? oaooa??a oa
ciaioaiiy o?eaaeino? ?o aeeooy [O.A.Eoaeeiiaa, 1990; ?.A.Oooa?aa, 1997].
Ia i?aai?ci a??iee?a aieeaa? oe?eee eiiieaen oe?aeeeaeo /eiiee?a
ae?iaieoeoaa, a naia: aaaeea o?ce/ia i?aoey, i?e?iee?iao, ui iaa??aa?,
caa?oaeiaiiy iia?o?y, ?ioaineaiee ooi, a?a?aoe?y, i?aeaeuaiee
aa?iiao?e/iee oene, ae?y o?i?/ieo ?a/iaei, a?iien?y oa i?aeaeuaiee
?aae?aoe?eiee oii, ye? aeeeeeathoue ci?ie o ooieoe?iioaaii? iecee nenoai
? i?aai?a c ianooiiei ?icaeoeii o ieo iaoieia?/ieo ci?i [A.A.Iaieiaa,
1995; I.O.Ecia?ia, 1997; E.Hnizdo, 1992; N.L.Lapp, 1994].

Aeeiiaiiy aaaeeeo ?ia?o a oiiaao i?e?iee?iaoo, ui iaa??aa?, aaaea aei
?icaeoeo aino?iai oa o?ii?/iiai ia?aa??aaiiy ?ia?oiee?a [TH.A.Ao?iae,
1996; A.I.Aaeooeeia, 1996], c?inoaiiy e?eueeino? caoai?thaaiue ia/?iee
[I.A.Ea?iaoo, 1993; A.I.Iei?ieia, 1998] oa ie?ie [A.ss.Ieioeei, 1998].
I?ioa iaoiaaiac ooeiaeaeoth/iai aieeao i?aecaiiiai na?aaeiaeua ia
aioo??oi? i?aaie ethaeeie iiai?noth ia anoaiiaeaiee.

Oe?aeeea? /eiieee aeeaiei? aoa?eueii? oaooe iiaeooue ni?e/eiyoe
ii?ooaiiy ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie (?AAN),
aiaeii-nieueiaiai iai?io (ANI) oa nenoaiii? aaiiaeeiai?ee [A.M.Aeaa?nii,
1994; E.A.Ie??a, 1995; J.I.S.Robertson, 1993; B.M.Brenner, 1996], ae?y
yeeo o?nii iia’ycaia c ie?eiaei neioacii i?inoaaeaiaeei?a [N.Awan, 1996;
M.T. Llinas, 1997] ? aacii?aneiii ieacie e?ia? [R.L.Zerbe, 1994; I.Jo,
1995]. Ci?ie, ui a?aeaoaathoueny a i?aai?ci? a??iee?a i?e aeeiiaii?
aaaeeeo o?ce/ieo ?ia?o, i?ecaiaeyoue aei iiyaeaiiy i?ioa?io???
iai?oaeaiiy oa aaiaoo??? i?ney iaaaioaaeaiiy, iaoai?cie yeeo ia
c’yniaai? [E.A.Oa?aaaa, 1995; I.O.Aeoaea?, 1996; R.J.Glassock, 1996].

Eiiieaeniee aieea ae?iaie/eo /eiiee?a aaaea aei iineaaeaiiy
aioeieneaeaioiiai caoenoo [A.Ae.Eoeuyi/oe, 1995, S.Nagase, 1997] oa
?ioaineo?eaoe?? ia?aeeniiai ieeneaiiy e?i?ae?a (IIE), ye? eaaeaoue a
iniia? aeanoaa?e?caoe?? iaia?aiieo no?oeoo? ? ?icaeoeo iaoieia?/ieo
i?ioean?a [A.I.Aecoaai, 1997; M.J.Wang, 1995]. A?aecia/a?oueny, ui
?ioaineai?noue IIE o?nii iia’ycaia c? noaiii ?ioiii? ?aaeoeaiino?
i?aai?cio [A.A.Ai?aeiiin, 1993, A.O.I.Naeai, 1995], a ?? cieaeaiiy a
oiiaao ae?? oaeoi??a i?iieneiaiai ae?iaieoeoaa iiaea noaoe i?e/eiith
?icaeoeo iaoieia?? aioo??oi?o i?aai?a [A.I.O?ieia, 1998]. Na?aae
?aaoethth/eo /eiiee?a ?ioi?oaoo aaaeeeaa i?noea caeia? ai?iii oeiono
a1-oeiicei [A.A.ss?eeei, 1996]. A?euei? ?aaeeeaee, ui noai?ththoueny a
?acoeueoao? IIE, yaeythoue niaith aaaeeea? /eiieee, ye? aeeeeeathoue
ooieoe?iiaeuei? oa ii?oieia?/i? ci?ie o aioo??oi?o i?aaiao, iniaeeai a
ia/?ioe? [I.A.Ianyiieeiaa, 1995] ? ie?eao [A.N.Na?ioeeoeueeee, 1995].

Anoaiiaeaii, ui ia/?iea ? iaea?eueo /ooeeaei i?aaiii aei ae??
i?e?iee?iaoo, ui iaa??aa? [O.A.Iaaeiaa, 1995], oa o?i?/ieo ?a/iaei
[I.A.No?i?ei, 1998], cia/ou?noue yeeo i?aeneeth?oueny i?e ii?aeiaii? c
aeeiiaiiyi aaaeeeo ?ia?o, i?aeaeuaii? aa?iiao?e/iiai oeneo oa ?ioeie
/eiieeaie i?aecaiiiai na?aaeiaeua [?.A.Eiiuoeia, 1995]. I?e oeueiio
a?aei?/aii, ui i?e ia?aa??aaii? aeieeathoue no?oeoo?i? ci?ie ia/?iee
[A.I.Iiaaaeueiiiay, 1994], a iniia? yeeo eaaeeoue oieiaa ?aaeoe?y c
nenoaiiei o?aaeaiiyi i?e?ioee?eoeyoi?iiai ?onea, ye? aeyaeythoueny
aoi?eiiei ?oai?/iei ooeiaeaeaiiyi i?aaio a aeaeyae?
aeeno?io?/ii-iae?ioe/ieo ci?i [A.I.Oeoeei, 1995].

A iao /an ae?aaiinoeea ? e?eoaaiiy caoai?thaaiue ia/?iee oa
na/iaeae?eueii? nenoaie o ?ia?oiee?a i?iieneiaeo i?aei?e?inoa
a?aeaoaa?oueny, a iniiaiiio, ia noaae?? ee?i?/ieo i?iya?a oai?iae oa
iaiaaeaiiy i?aoeacaeaoiino? [?.O.Aoaianueaaa, 1997; A.I Aeaieeee.,
1997]. Aeyaeaiiy ?aii?o ii?ooaiue ooieoe?iiaeueiiai noaio aioo??oi?o
i?aai?a ? aea/aiiy iaoai?ci?a ?o ?icaeoeo aeicaieeoue ?ic?iaeoe iaoiaee
?aiiuei? i?io?eaeoeee, e?eoaaiiy oa ?aaa?e?oaoe?? a??iee?a.

Iaeiae ?ia?o, i?enay/aieo eiiieaeniiio aeine?aeaeaiith ?aii?o ii?ooaiue
ooieoe?iiaeueiiai noaio ia/?iee oa na/iaeae?eueii? nenoaie o i?aecaiieo
a??iee?a aeeaieeo aoa?eueieo oaoo, iiooeai iaoiaaiaoe/ieo iaoai?ci?a
oeeo ii?ooaiue, iaia?. I?iaaaeaiiy oaeiai aeine?aeaeaiiy ia? i?aeoe/ia
cia/aiiy, ine?eueee aiii iiaea iioe?eoe iao? oyaeaiiy i?i iaoai?cie
oi?ioaaiiy iaoieia?? ia/?iee oa ie?ie, iiaeeea? oeyoe i?io?eaeoeee,
e?eoaaiiy ? ?aaa?e?oaoe?? a??iee?a.

Ca’ycie ?iaioe c iaoeiaeie i?ia?aiaie, ieaiaie, oaiaie. Oea
aeine?aeaeaiiy (?aa.?01890069866) i?iaiaeeeiny ca ieaiii iaoeiaeo ?ia?o
eaoaae?e oa?ai?? oaeoeueoaoo i?neyaeeieiiii? ina?oe Eoaainueeiai
aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Iaoa aeine?aeaeaiiy. Aeyaeoe ?aii? i?iyae oa anoaiiaeoe iaoai?cie
?icaeoeo caoai?thaaiue ia/?iee ? ie?ie o i?aecaiieo a??iee?a aeeaieeo
aoa?eueieo oaoo, ?ic?iaeoe niiniae ?o i?io?eaeoeee.

Caaea/? aeine?aeaeaiiy:

1. Aea/eoe caoai?thaai?noue a??iee?a aeeaiei? aoa?eueii? oaooe.

2. Aeyaeoe a?oio i?aeoe/ii caei?iaeo a??iee?a oa i?iaanoe ?o iiaeeaeaia
ianoaaeaiiy.

3. Aea/eoe ooieoe?iiaeueiee noai ia/?iee a??iee?a ia i?aenoaa?
aeine?aeaeaiiy a?io?i?/ieo iieaciee?a a caeaaeiino? a?ae aaaeeino?
aeeiioaaieo ?ia?o.

4. Aea/eoe noai oeaio?aeueii? aaiiaeeiai?ee a??iee?a ? aecia/eoe ?ieue
?? ci?i a ?icaeoeo caoai?thaaiue ia/?iee oa ie?ie.

5. Aecia/eoe ?ieue ?AAN, aacii?aneio, aiaeioae?io-1 ? neioaco
i?inoaaeaiaeei?a a ie?eao o aeieeiaii? ii?ooaiue ANI o i?aecaiieo
a??iee?a aeeaieeo aoa?eueieo oaoo, c’ynoaaoe iaoiaaiaoe/i? iaoai?cie
ii?ooaiue ooieoe?iioaaiiy oeeo nenoai oa ?o ?ieue a o?aaeaii? ie?ie.

6. Anoaiiaeoe iaoai?cie ?icaeoeo i?ioa?io??? iai?oaeaiiy.

7. Anoaiiaeoe iaoai?cie ?icaeoeo aaiaoo??? i?ney iaaaioaaeoaaiiy.

8. Aecia/eoe ?ieue i?e?iee?iaoo, ui iaa??aa?, a ?icaeoeo ii?oieia?/ieo
ci?i ? ii?ooaiue ooieoe?iiaeueiiai noaio ia/?iee oa ie?ie
(ee?i?ei-aenia?eiaioaeueia aeine?aeaeaiiy).

9. Aeine?aeeoe noai IIE ? nenoaie aioeieneaeaioiiai caoenoo, aeyaeoe
oa?aeoa? ci?i oa aecia/eoe ?o ?ieue a ?icaeoeo caoai?thaaiue ia/?iee oa
ie?ie o a??iee?a.

10. Aea/eoe noai ?ioiiiai noaoono o i?aecaiieo a??iee?a aeeaieeo
aoa?eueieo oaoo, c’ynoaaoe oa?aeoa? ci?i oa aecia/eoe ?o ?ieue a
?icaeoeo caoai?thaaiue ia/?iee oa ie?ie.

11. ?ic?iaeoe ? i?iaanoe ai?iaaoe?th iaoiae?a i?io?eaeoeee caoai?thaaiue
aioo??oi?o i?aai?a o a??iee?a aeeaieeo aoa?eueieo oaoo.

Iaoeiaa iiaecia iaea?aeaieo ?acoeueoao?a. Aia?oa o i?aeoe/ii caei?iaeo
a??iee?a aeeaieeo aoa?eueieo oaoo i?iaaaeaii eiiieaenia aea/aiiy ?aii?o
ii?ooaiue ooieoe?iiaeueiiai noaio ia/?iee oa ie?ie, a oaeiae noaio
ia?aeeniiai ieeneaiiy e?i?ae?a, nenoaie aioeieneaeaioiiai caoenoo oa
?ioiiiai noaoono.

Aia?oa aecia/ai? ii?ooaiiy ooieoe?? ia/?iee, ye? aeyaeythoueny a
cieaeaii? ai?noo aeueaoi?i?a o ne?iaaooe? e?ia?, iniaeeai cia/iiio o
iieiaeeo a??iee?a oa a??iee?a c i?aecaiiei noaaeai aei 5 ?ie?a;
a?aeiiniiio i?aeaeuaii? ??ai?a o?ainai?iac, ??aiy oieanoa?eio oa
-e?iii?ioa?ae?a a ne?iaaooe? e?ia?, ia?aaaaeii o ?ia?oiee?a iniiaieo
i?ioan?e.

Aeyaeaii, ui a?oiith ?eceeo ?icaeoeo caoai?thaaiue ia/?iee ? iieiae?
?ia?oieee (20-30 ?ie?a) oa iniae c iaaaeeeei i?aecaiiei noaaeai (aei 5
?ie?a), ye? iaea?eueo noeeuei? aei ae?? oe?aeeeaeo /eiiee?a aeeaiei?
aoa?eueii? oaooe.

Aia?oa aeyaeaii cia/ia cieaeaiiy ??aiy ai?iiio oeiona a1-oeiiceio o
a??iee?a aeeaieeo aoa?eueieo oaoo.

Aecia/aii, ui a ?icaeoeo ?ioiiaeao?oeeoiiai noaio o a??iee?a aa?a
o/anoue aeao?oeeo ai?iiio oeiona — a1-oeiiceio.

Anoaiiaeaii, ui oaeoi?aie ?eceeo ?icaeoeo caoai?thaaiue ie?ie ? cia/i?
ii?ooaiiy aiaeii-nieueiaiai iai?io, ye? noi?iaiaeaeothoueny ci?iith
aeoeaiino? ?AAN, aacii?aneio ieacie e?ia?, neioaco i?inoaii?ae?a, ?
oeaio?aeueii? aaiiaeeiai?ee a caeaaeiino? a?ae aaaeeino? aeeiioaaieo
?ia?o, a?eo oa noaaeo ?iaioe.

Aecia/aii i?aeaeuaiiy ??aiy aiaeioae?io-1 a ieaci? e?ia? o a??iee?a a
caeaaeiino? a?ae aaaeeino? aeeiioaaieo ?ia?o.

Aia?oa cai?iiiiiaaia a?iioaca ?icaeoeo i?ioa?io??? iai?oaeaiiy o
a??iee?a aeeaieeo aoa?eueieo oaoo.

Aia?oa c’yniaai? iaoai?cie ?icaeoeo aaiaoo??? i?ney iaaaioaaeaiiy, yea
aeieea? i?e ci?i? ANI, i?aeaeuaii? aeoeaiino? ?AAN ? neioaco o?iiaienaio
a ie?eao, i?e iiaiiio ii?ooaii? aca?iica’yceo iii?ae aeine?aeaeoaaieie
?aaoeyoi?ieie nenoaiaie.

Aia?oa iieacai? oeueo?ano?oeoo?i? ?ic??ciaiiy a ?aaeoe?? ee?oei ia/?iee
oa i?ieneiaeueieo eaiaeueoe?a ie?ie ia ia?aa??aaiiy ? iaaaaeai?
aeaeo?iiii-i?e?ineii?/i? oa aeaeo?iiiia?noio?i?/i? e?eoa??? ?o
?ici?ciaaaiiy.

Aia?oa iieacaia aeeiai?ea ii?ooaiue IIE ? nenoaie aioeieneaeaioiiai
caoenoo, a oaeiae ?icaeoeo aoi?eiiiai ?ioiiaeao?oeeoiiai noaio a
caeaaeiino? a?ae aaaeeino? i?aoe? ? noaaeo ?iaioe a??iee?a oa ?o ?ieue a
?icaeoeo caoai?thaaiue ia/?iee oa ie?ie.

Cai?iiiiiaaia noaia iaoiaaiaco ?icaeoeo caoai?thaaiue ia/?iee o a??iee?a
aeeaieeo aoa?eueieo oaoo.

?ic?iaeai? oa ai?iaiaai? iia?, iaoiaaiaoe/ii iaa?oioiaai? iaoiaee
i?io?eaeoeee caoai?thaaiue ia/?iee oa ie?ie o a??iee?a, ye? iieyaathoue
o aeei?enoaii? i?aia?ao?a “Ni??oe?ia”, “Ai?cii” ? “Aio?aeue”.

I?aeoe/ia cia/aiiy iaea?aeaieo ?acoeueoao?a. ?acoeueoaoe aeine?aeaeaiue
iiaeia oe?iei aeei?enoiaoaaoe a i?aeoeoe? ioi?iie caei?ia’y.

Ai?iaaaeaeaiiy eiiieaeniiai aeine?aeaeaiiy ooieoe?iiaeueiiai noaio
ia/?iee, na?oeaai-noaeeiii? oa na/iaeae?eueii? nenoai i?ae /an
i?io?eaeoe/ieo iaeyae?a a??iee?a aeeaieeo aoa?eueieo oaoo aeicaiey?
aeyaeoe a?oio ?ia?oiee?a c i?aeaeuaiei ?eceeii ?icaeoeo iaoieia?? oeeo
i?aai?a, ?ic?iaeoe i?ia?aio aeeniaina?iiai niinoa?aaeaiiy,
i?io?eaeoe/iiai e?eoaaiiy oa ?aoe?iiaeueiiai i?aoeaaeaoooaaiiy.

?aii? aeyaeaiiy ?ia?oiee?a c iiyaith i?ioa?io??? iai?oaeaiiy oa
iinoiaaaioaaeoaaeueii? aaiaoo??? ? ei?aeoe?y oeeo noai?a aeicaiey?
caiia?aoe ?icaeoeo caoai?thaaiue na/iaeae?eueii? nenoaie.

I?eaa?iaiiy oaaae e?ea??a aei caei?ia’y iieiaeeo a??iee?a (a?eii 20-30
?ie?a) oa ?ia?oiee?a c iaaaeeeei i?aecaiiei noaaeai (aei 5 ?ie?a), ye?
ua ia aaeaioiaai? aei oiia aeeaiei? aoa?eueii? oaooe, aeicaieeoue
cieceoe caoai?thaai?noue oa cia/ii i?aeaeueoe ?o i?aoeacaeaoi?noue.

Aeei?enoaiiy io?eiaieo aeaieo i?i ?ieue aeanoaa?e?caoe?? e?ciniiaeueieo
iaia?ai ye i?e/eie ?icaeoeo iae?ic?a a ee?oeiao ia/?iee ? ie?ie,
ii?ooaiiyo IIE, aioeieneaeaioii? nenoaie oa ?ioiiiai noaoono aeicaiey?
aeeth/eoe aei eiiieaeno i?io?eaeoe/ieo caoiae?a i?aia?aoe “Ni??oe?ia”,
“Aio?aeue” ? “Ai?cii”, ye? iathoue iaia?aiinoaa?e?coth/o,
aioeieneaeaioio oa ?ioiiiiaeoethth/o ae?th.

I?aeoe/ia canoinoaaiiy iiaiai niiniao ?aiiuei? i?io?eaeoeee
caoai?thaaiue ia/?iee ? ie?ie o i?aecaiieo a??iee?a aeeaieeo aoa?eueieo
oaoo oa ?aoe?iiaeueia i?aoeaaeaoooaaiiy caiia?aa? ?icaeoeo ii?ooaiue
ooieoe?iiaeueieo noai?a oeeo i?aai?a ? ni?ey? niia?eueiaiith oaii?a
?icaeoeo caoai?thaaiue (Iaoaio Oe?a?ie ?21063 A a?ae 04. 11. 97 ?. oa
Ooaaeueia ??oaiiy ia aeiao?ae ? 98010098/A a?ae 8.01.98 ?.).

Io?eiai? aeai? aeei?enoiaothoueny a eaeoe?eiiio eo?n? aeey nooaeaio?a,
e?ea??a-?ioa?i?a oa neooa/?a oaeoeueoaoo i?neyaeeieiiii? ina?oe
Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Ca ?acoeueoaoaie aeine?aeaeaiue i?aeaioiaeai? iaoiaee/i? ?aeiiaiaeaoe??.
Ioi?ieai? oa io?eiai? na?ae/aiiy ia 9 ?aoe?iiae?caoi?nueeeo i?iiiceoe?e.

Iniiai? ?acoeueoaoe i?iaaaeaieo aeine?aeaeaiue ai?iaaaeaeai? a i?aeoe/io
?iaioo Eoaainueei? iaeanii? ee?i?/ii? e?ea?i?, Aeiiaoeueeiai iaeaniiai
ee?i?/iiai oa?eoi??aeueiiai iaaee/iiai ia’?aeiaiiy, iaaeeei-nai?oa?ieo
/anoei i.E?aniiaeii, i.Noaoaiia, i.Ae/aanuee, i.E?aniee Eo/,
i.Aio?aoeeo, i.Iao?ianueea, i.Naa?aeeianuee, i.?iaaiueee.

Iniaenoee aianie caeiaoaa/a. Aaoi?o iaeaaeeoue aea?? oaie, aecia/aiiy
aaeaeaaoii? iaoe ? caaaeaiue aeine?aeaeaiiy, iaoiaeieia?/ieo iniia ??
aeeiiaiiy. Aeena?oaioii naiino?eii i?iaiaeeeenue ?aae?i?ioiieia?/i?
aeine?aeaeaiiy aeoeaiino? ?ai?io ieacie e?ia?, ??aiy aeueaeinoa?iio a
e?ia? oa na/?, ??aiy aacii?aneio oa aiaeioae?io-1 a ieaci? e?ia?, ??ai?a
o?iiaienaio A2 ? i?inoaoeeee?io a na/?, ??aiy i?inoaaeaiaeeio F2 a na/?,
aeine?aeaeaiiy aaiiaeeiai?ee, a oaeiae i?aeaioiaea iaoa??aeo a?ieia?/ieo
??aeei aeey aecia/aiiy aeaeo?ie?o?a ? e?aaoei?io, iieaciee?a IIE,
?ioiiiai noaoono, oa?iaio?a aioeia?aeeniiai caoenoo, aecia/aiiy yeeo
i?iaiaeeeiny o a?aeiia?aeieo eaai?aoi??yo. Caeiaoaa/ai naiino?eii
i?iaaaeaii aenia?eiaioaeueia aeine?aeaeaiiy. Aaoi?ii aoei i?iaiae?ciaaii
io?eiai? ?acoeueoaoe ca aeiiiiiaith eiii’thoa?ii? i?ia?aie, yeo a?i
naiino?eii aaeaiooaaa aeey i?iaaaeaiiy oe??? ?iaioe. Aaoi?ii naiino?eii
i?iaiaeeany aea?? i?aia?ao?a aeey ei?aeoe?? aeyaeaieo ci?i oa ?ic?iaea
noai ?o canoinoaaiiy.

Ai?iaaoe?y ?acoeueoao?a aeena?oaoe??. Iaoa??aee aeena?oaoe??
aeiiia?aeaeeny ia IX i?aeia?iaeiiio eieiea?oi? AN?AI ii iao?ieia??
(Naoe, Ei?ay, 1992), onoaiia/?e eiioa?aioe?? iaoeiaiai oiaa?enoaa
iao?ieia?a ?in?? (Iineaa, 1992), III ?aa?iiaeuei?e iaoeiai-i?aeoe/i?e
eiioa?aioe?? iieiaeeo a/aieo “Yeieiaey i?iiuoeaiiiai ?aaeiia Aeiiaanna”
(Eoaainuee, 1993), III i?aeia?iaei?e eiioa?aioe?? c i?aaaioeaii?
ea?ae?ieia?? (Inei, Ii?aaa?y, 1993), XIII i?aeia?iaeiiio iao?ieia?/iiio
eiia?an? (Iaae?eae, ?niai?y, 1995), ?aa?iiaeuei?e eiioa?aioe?? “I?iaeaiu
iaia?aiiie iaoieiaee a iaaeeoeeia” (Aeiiaoeuee, 1995), neiiic?oi?
“Oeceieiaey ii/ee e aiaeii-nieaaiai iaiaia” (Iiainea??nuee, 1995),
?aa?iiaeuei?e eiioa?aioe?? “I?iaeaiu iaia?aiiie iaoieiaee a iaaeeoeeia”
(Aeiai?iiao?ianuee, 1995), anana?oi?e eiioa?aioe?? ii eiio?ieth ca
a?ia?oaic??th (Iooaaa, Eaiaaea, 1995), ?anioae?eainuee?e eiioa?aioe??
“Ia?aeiiee i??eiiao?eo. ?ioa?noeoe?aeueiee iao?eo” (Oa?iii?eue, 1995),
III Naieo-Iaoa?ao?cueeiio nai?ia?? (Naieo-Iaoa?ao?a, 1995),
?aa?iiaeuei?e iaoeiai-i?aeoe/i?e eiioa?aioe?? “Nia?aiaiiua oaoiieiaee:
iienee, i?iaeaiu e iooe iiauoaiey yooaeoeaiinoe niaoeeaeece?iaaiiie
iaaeeoeeineie iiiiue ianaeaieth i?iiuoeaiiiai ?aaeiia” (Eoaainuee,
1995), XXXII i?aeia?iaeiiio eiia?an? ?a?iiaenei? Ie?eiai? Anioe?aoe??
(Ao?ie, A?aoe?y, 1995), ?aa?iiaeuei?e eiioa?aioe?? “100-eaoea iniiaaiey
4-e ai?iaeneie aieueieoeu” (Eoaainuee, 1996), ?anioae?eainuee?e
iaoeiai-i?aeoe/i?e eiioa?aioe?? “?ieue caaaeueiii?aeoeeoth/iai e?ea?y o
?ica’ycaii? i?iaeai i?io?eaeoeee ia?ioaeoe?eieo caoai?thaaiue” (Oa?e?a,
1997), Oino?e anaoe?a?inuee?e ia?aae? c ieoaiue iie?ee?i?/ii? ni?aae
(Euea?a, 1997), ?anioae?eainuee?e iaoeiai-i?aeoe/i?e eiioa?aioe??
“Aeinyaiaiiy oa iaae??oai? ieoaiiy aano?iaioa?ieia??” (Oa?e?a, 1998), I
iaoe?iiaeueiiio eiia?an? Oe?a?ie ii ?ioiieia??, aea?aieia?? oa
?ioii?aaa?e?oaoe??. (Aeoooa, E?ei, 1998), XIV c’?cae? oa?aiaao?a Oe?a?ie
(Ee?a, 1998).

Aeena?oaoe?y aoea ai?iaiaaia ia ni?eueiiio can?aeaii? oanoe eaoaae?
oa?ai??, eaoaae?e caaaeueii? a?a??ie oa aeieia?? ? eaoaae?e
i?e?ia?ieia?? Eoaainueeiai aea?aeaaiiai iaaee/iiai oi?aa?neoaoo.

Ioae?eaoe??. Ca iaoa??aeaie aeena?oaoe?? iioae?eiaaii 40 ?ia?o, a oiio
/ene? 1 iiiia?ao?y, 8 aeaa o iiiia?ao?yo oa 17 noaoae o ia??iaee/ieo
aeo?iaeao. Cai?iiiiiaai? 2 niiniae i?io?eaeoeee ?ioiiaeao?oeeoiiai noaio
(Iaoaio Oe?a?ie ?21063 A a?ae 4. 11. 97 ?., oa Ooaaeueia ??oaiiy ia
aeiao?ae ? 98010098/A a?ae 8.01.98 ?.).

No?oeoo?a oa ianya aeena?oaoe??. Aeena?oaoe?y aeeeaaeaia ia 355
noi??ieao ae?oeiaaiiai oaenoo ? neeaaea?oueny ?c anooio, 4 ?icae?e?a
(iaeyae e?oa?aoo?e, aea? aeaae iniaenoeo aeine?aeaeaiue oa iaaiai?aiiy),
aeniiae?a, nieneo aeei?enoaieo aeaea?ae oa aeiaeaoe?a. ?iaioa ia? 52
iaethiea ? 29 oaaeeoeue. Nienie aeei?enoaieo e?oa?aoo?ieo aeaea?ae
aeeth/a? 599 iaeiaioaaiue.

CI?NO ?IAIOE

Iaoa??aee oa iaoiaee aeine?aeaeaiiy. Aeine?aeaeaiiy i?iaiaeeeenue ia
oaoo? «Iieiaeiaaa?ae?enueea» AeOE «E?aniiaeiiaoa?eey» ? oaoo? «I?eaii?»
AeOE «Eoaainueeaoa?eey». Iaeaea? oaooe ? oeiiaeie aoaeaaeiaoaieie
i?aei?e?inoaaie Aeiiaano. Anueiai ianoaaeaii 1600 i?aecaiieo a??iee?a, c
yeeo aoei a?ae?a?aii 238 i?aeoe/ii caei?iaeo i?aecaiieo ?ia?oieea c
iaaaoeaiith ?aaeoe??th ia HBsAg. 90% ianoaaeaieo neeaaeaee iniae a?eii
a?ae 20 aei 50 ?ie?a. A?eueo?noue ianoaaeaieo (70%) iaee i?aecaiiee
noaae ?iaioe a?ae 5 aei 20 ?ie?a. ?ia?oieee oae caaieo «iniiaieo»
oaooa?nueeeo i?ioan?e (A?AC, i?io?aeieee), ye? aeeiiothoue aaaeeo ?iaioo
a iaeiani?eyoeea?oeo oiiaao i?aecaiiiai i?e?iee?iaoo neeaee 125 /ieia?e,
aai 54% a?ae caaaeueii? e?eueeino? ianoaaeaieo.

An? ianoaaeai? aoee ?iciiae?eai? ia a?oie: I — an? ianoaaeai? a??ieee;
II — iniae, ui i?aoethaaee a iaeiani?eyoeea?oeo i?aecaiieo oiiaao oa
aeeiioaaee ?iaioe aaeeei? aaaeeino?; III — iniae, ye? aeeiioaaee ?iaioe
na?aaeiuei? aaaeeino?; IY — iniae, a yeeo c’yaeyeanue i?ioa?io??y i?ney
?iai/i? ci?ie (aeueaoi?io??y 0,1-0,2 a/e); Y — iniae, a yeeo c’yaeyeanue
i?e?iaaiaoo??y i?ney ?iai/i? ci?ie (a?eo?ioeeoe a na/? 5-15·106/e).
Eiio?ieueio a?oio neeaee 80 caei?iaeo in?a. Aeey anoaiiaeaiiy aieeao
a?eo oa noaaeo ?iaioe a i?aecaiieo oiiaao ia aeine?aeaeoaai? iieacieee
on? ianoaaeai? aoee ?iciiae?eai? ia a?oie ca a?eii: 20-30 ?ie?a; 31-40
?ie?a; 41-50 ?ie?a oa 51-60 ?ie?a; oa ca noaaeai: aei 5 ?ie?a ; 5-10
?ie?a; 11-15 ?ie?a;16-20 ?ie?a oa 21-25 ?ie?a.

Aeine?aeaeaiiy a?e??oa?io, caaaeueiiai a?eeo, aeueaoi?i?a, aeiaoe?i?a,
oieanoa?eio, ?-e?iii?ioa?ae?a, oeiieiai? i?iae, aeai?iiai?
ai?iio?ainoa?ace (AeAO) oa ania?aa?iiai? ai?iio?ainoa?ace (AnAO) o
ieaci? e?ia? i?iaiaeeeinue ca caaaeueiii?eeiyoeie iaoiaeeeaie
(A.A.Ia?aaea??e, 1993).

Aea/aiiy noaio oeaio?aeueii? aaiiaeeiai?ee i?iaiaeeeinue iaoiaeii
oao?aiiey?ii? ?aia?ao?? (O.N.Aeiia?aaeiaa, 1986; I.N.Eooaeianeee, 1995).
?a?no?aoe?th ?aiieaoeciia?ai aeeiioaaee ca aeiiiiiaith ?aia?aoa «?IA
2-02» oa ?a?no?aoe?eiiai i?eno?ith «Cardimax FX-326U (Fukuda Denshi,
ssiii?y).

I?e aeine?aeaeaii? noaio ANI oa ?AAN a??ieee aoee ianoaaeai? aea?/?:
aei oa i?ney ?iai/i? ci?ie (aacaeueiee oa noeioeueiaaiee ia??iaee
a?aeiia?aeii). O an?o ianoaaeaieo aecia/aany ai?no aeaeo?ie?o?a ?
e?aaoei?io a ne?iaaooe? e?ia? oa na/? (ca cae/aeieie iaoiaeeeaie), a
oaeiae aeoeai?noue ?ai?io ieacie (A?I), ??aaiue aeueaeinoa?iio a ieaci?
e?ia? (?A), ??aaiue aene?aoe?? aeueaeinoa?iio c na/ath (UA), ??aaiue
aacii?aneio (Vas) a ieaci? e?ia?, ??aaiue neioaco a ie?eao o?iiaienaio
OoA2 (ii aene?aoe?? iaoaaie?oo OoA2), i?inoaoeeee?io PgI2 (ii aene?aoe??
iaoaaie?oo 6-eaoiPgF1), i?inoaaeaiaeeio PgF2 aea/aany ca aeiiiiiaith
iaai??a ?aaeoea?a ?aae?i?ioiieia?/iei iaoiaeii (B.M.Jaffe, 1979):
«SB-REN-2», «SB-ALDO-2» (ae?iaieoeoaa o??ie CIS, O?aioe?y),
«VASOPRESSIN-RAPID» (Buhlman Lab. AG, Oaaeoea??y), «6-eaoiPgF1», «PgF2»
? «OoA2» (?inoeooo ?cioii?a Oai?nueei? aeaaeai?? iaoe). ?aae?iiao??th
c?ace?a ? inoaoi/iee ?ic?aooiie cae?enithaaee ia onoaiiaoe? «AAIIA-12» a
aaoiiaoe/iiio ?aaeei? ca niaoe?aeueiith i?ia?aiith EN-8072019.

Ai?no aiaeioae?io-1 (A-1) a ieaci? e?ia? aecia/aany ?ioiioa?iaioiei
iaoiaeii c aeei?enoaiiyi noaiaea?oieo iaai??a “The Biotrak TM
endotelin-1 ELISA system” o??ie Amersham ca?aeii ?aeiiaiaeaoe?e o
i?ioieie?. I?e i?iaaaeaii? ?ioiioethi?anoeaioiiai aiae?co
aeei?enoiaoaaee niaeo?ioioiiao? PR-2100 (O?aioe?y).

Iaoa??aeii aeey aenia?eiaioaeueiiai aeine?aeaeaiiy aoee 85 a?eeo uo??a,
yeeo ?ici?uoaaee a oaieia?e eaia?? c oaiia?aoo?ith iia?o?y 45iN oa
a?aeiiniith aieia?noth 65%. Eiio?ieueio a?oio neeaee 10 oaa?ei. An?
oaa?eie caciaee ii?oieia?/iiai aeine?aeaeaiiy, yea aeeth/aei na?oeiao
i?e?ineii?th, aeaeo?iiio i?e?ineii?th («JEM-7A», ssiii?y), e?euee?nia
ii?oiiao?e/ia (A.A.Aaoaiae?eia, 1984), oa aeaeo?iiiia?noio?i?/ia
aeine?aeaeaiiy eenei? oinoaoace (EO) — ia?ea?iiai oa?iaioo
e?ciniiaeueii-aaeoiey?iiai aia?aoo ee?oei (A.ss.Ieioe?i, 1992).

?ioaineai?noue i?ioean?a IIE aecia/aeanue ii ai?noo a ieaci? e?ia?
ae??iiaeo eii’thaao?a (AeE) ? iaeiiiaiai ae?aeueaeaa?aeo (IAeA).
Aeoeai?noue oa?iaio?a aioeieneaeaioii? nenoaie — noia?ieneaeaeeniooace
(NIAe) a a?eo?ioeeoao e?ia? ? eaoaeace (EO) a ne?iaaooe? e?ia?
aeyaeyeany niaeo?ioioiiao?e/iei iaoiaeii ca oa?aeoa?iei iaeneioiai
iiaeeiaiiy a oeueo?ao?ieaoiaiio niaeo?? (?.A.Iaea?aiei, 1988;
I.A.Ei?iethe, 1988).

Aecia/aiiy O-e?ioioeeo?a, noaiiioeyoe?e O-oaeia?ia/?iaeoeoi??a ?
O-noi?ani??a/e?ea??a, A-e?ioioeeo?a cae?enithaaeinue c aeei?enoaiiyi
iaiae? iiiieeiiaeueieo aioeo?e CD3, CD4, CD8, CD22 (Orho Diagnostic
Systems Inc., NOA; A.I.O?ieia, 1989). ?ioiiaeiaoe?ie ne?iaaoee eean?a A,
I, G aecia/aee iaoiaeii ?aae?aeueii? ?ioiiaeeooc?? (G.Mancini, 1965).

Aecia/aiiy ai?noo a ne?iaaooe? e?ia? a1-oeiiceio (a1O) i?iaiaeeeiny
?aae?i-?ioiieia?/iei iaoiaeii a eaai?aoi??? ?ioiia?ioaoiieia?? IAe?
oaoiieia?? e?iaicai?ithaa/?a oa ai?iiiaeueieo i?aia?ao?a, i. Iineaa.

Oa?/iaa aeiaaaea «Ni??oe?ia» i?ecia/aeanue 20 a??ieeai ii 1/2 /. e.
(1-1,25 a) o?e/? ia aeiao, i?ae /an ?ae?, i?ioyaii 10 aei?a. I?aia?ao
«Ai?cii» i?ecia/aany 18 a??ieeai ii 1 oaa. (0,25 a) — o?e/? ia aeiao
i?ioyaii 5 aei?a. I?aia?ao «Aio?aeue» i?ecia/aany 15 a??ieeai ii 1 oaa.
(0,2 a) o?e/? ia aeiao i?ioyaii 10 aei?a.

Iaea?aeai? aeai? ia?iaeyeeny ca aeiiiiiaith niaoe?aeueiiai iaeaoo
i?eeeaaeieo i?ia?ai ia AII IBM PC-486 AT.

?acoeueoaoe aeine?aeaeaiiy oa ?o iaaiai?aiiy. Aiae?c caoai?thaaiino? ia
oaoo? “I?eaii?” iieacaa, ui caoai?thaai?noue oai?iaaie ia/?iee oa
aeia/iaea?aeieo oeyo?a c?inoaea c 1993 ii 1996 ??e. Aei oiai ae, o 1996
?ioe? a?aeaoeiny iaeneiaeueia ca?eueoaiiy iieaciee?a: a aeiaaeeao ia 1,3
(92,8%) oa a aeiyo iai?aoeacaeaoiino? ia 38,2 (100,3%), i?e oeueiio,
caoai?thaai?noue neeaea 34 aeiaaeee oa 948 aei?a oei/aniai? ao?aoe
i?aoeacaeaoiino? oa iaeaea aaea?/? ia?aaeueea na?aaei? iieacieee ii
Eoaainuee?e iaeano?.

I?ney eiiieaeniiai i?io?eaeoe/iiai iaeyaeo 850 a??iee?a aoee a?ae?a?ai?
77 i?aeoe/ii caei?iaeo oaooa??a. Aiae?c nea?a a??iee?a iieacaa, ui
iaea?eueo ?iciianthaeaeaieie na?aae a??iee?a aoee: anoaiiaaaaoaoeaiee
neiae?ii (3,2%), aeeniaine/iee neiae?ii (2,9%), a?ae/oooy aaaeeino? oa
aie? a i?aaiio i?ae?aaa?’? (1,8%), aie? a noaeiaao (1,2%). I?e oeueiio o
21,5% a??iee?a ca aeaieie oeueo?acaoeiaiai aeine?aeaeaiiy aecia/ai?
??ciiiai?oi? ci?ie.

Aeey ooi/iaiiy oa?aeoa?o aeyaeaieo ci?i aoei ?icii/aoa a?io?i?/ia
aeine?aeaeaiiy e?ia? a??iee?a. Iieacieee aiae?coaaeenue a caeaaeiino?
a?ae aaaeeino? ?ia?o, a?eo oa noaaeo a??iee?a. Aeyaeeiny, ui ai?no
caaaeueiiai a?eeo a e?ia? a??iee?a neeaa 68,69-73,0 a/e. I?e ii??aiyii?
c eiio?ieueiith a?oiith (74,6±2,8 a/e), o ?ia?oiee?a ?? a?oie
anoaiiaeaii cieaeaiiy caaaeueiiai a?eeo a e?ia?. Ai?no aeueaoi?i?a o
?ia?oiee?a on?o a?oi aoa cia/ii ieae/ee, i?ae o eiio?ieuei?e a?oi?. I?e
oeueiio iaea?eueo iecueeee ??aaiue aeueaoi?i?a a e?ia? (37,16±1,8%, ui
a?aeiia?aeii aei 25,53±1,2 a/e) a?aecia/aiee o ?ia?oiee?a ?? a?oie.
Ni?aa?aeiioaiiy aeueaoi?i?a oa aeiaoe?i?a (A/A) o ?ia?oiee?a on?o a?oi
aoei o iaaeao a?ae 0,59±0,14 aei 0,69±0,11 oa cia/ii ieae/ei iieaciee?a
eiio?ieueii? a?oie. Anoaiiaeaia o oaooa??a a?iiaeueaoi?iai?y iiaea aooe
iia’ycaia c aaaeeith o?ce/iith i?aoeath a oiiaao a?ia?oa?i??, yea
aeeeeea? aaeeea niiaeeaaiiy a?eeo neaeaoiith ioneoeaoo?ith, aai
ii?ooaiiyi aeueaoi?ineioacoth/i? ooieoe?? ia/?iee (N.Ae. Iiaeuiiaa,
1995).

??aaiue oieanoa?eio o a??iee?a ? oa ?? a?oi ia?aaeuoaaa eiio?ieuei?
iieacieee. Ai?no a-e?iii?ioa?ae?a ?ia?oiee?a ?? a?oie aeyaeany aeuei ca
aeai? eiio?ieueii? a?oie. A?aei?/ai? ii?ooaiiy e?i?aeiiai iai?io
iaea?eueo ae?aaeai? o ?ia?oiee?a, ui aeeiiothoue aaaee? ?iaioe a
iaeiani?eyoeeaeo i?e?i-ee?iaoe/ieo oiiaao, iiaeeeai, aeieeee i?ae
aieeaii aaaeei? o?ce/ii? i?aoe? (I.A.No?i?ei, 1997). Iaeiae, ci?ie
e?i?aeiiai iai?io iiaee aooe ? aoi?eiieie, aiane?aeie a?iiaeueaoi?iai??
(A.A.*e?eei, 1994). E??i oiai, anoaiiaeai? o oaooa??a ci?ie e?i?aeiiai
iai?io iiaee ?icaeiooeny i?e ii?ooaiiyo a ia/?ioe?, aeeeeeaieo
ia?aa??aaiiyi (A.I.Iiaaaeueiiiay, 1994).

Ai?no AeAO o a??iee?a ?? a?oie aoa aeuee, i?ae o eiio?ieuei?e a?oi?.
Eiao?oe??io aea ??o?na (AnAO/AeAO) o oeeo ?ia?oiee?a neeaa 0,77±0,12, ui
oaeiae aoei ieae/a eiio?ieueieo iieaciee?a. I?aeaeuaiiy AeAO, cieaeaiiy
eiao?oe??ioo aea ??o?na o a??iee?a, ui aeeiiothoue aaaee? ?iaioe a
iaeiani?eyoeeaeo oiiaao i?aecaiieo ae?iaie, iiaea na?ae/eoe ia ei?enoue
oeeoie?co aaiaoioeeo?a (I.A.Aoaa?a?eoe, 1999), yeee iia’ycaiee c
ia?aa??aii (A.Iaaeiaa, 1993).

I?e ?iciiae?eaii? a??iee?a ia a?eia? a?oie aeyaeeinue, ui ai?no
caaaeueiiai a?eeo aoa iaeieae/ei o a??iee?a 20-30 ?ie?a. A oe?e aea
a?eia?e a?oi? ai?no aeueaoi?i?a aeyaeany iaeiaioei ? neeaa 35,77±1,92% ,
ui nooo?ai a?ae??ciyeinue a?ae ??aiy aeueaoi?i?a o oaooa??a 41-50 ?ie?a
(41,98±1,5%).

I?i?iaeueiee ??aaiue oieanoa?eio (4,44±0,37 iiieue/e) aecia/aany o
iieiaeeo ?ia?oiee?a, a iaeneiaeueiee (6,1±0,2 iiieue/e) — a noa?o?e
a?eia?e a?oi?, c a?aei?iaie iii?ae ieie. ??aaiue a-e?iii?ioa?ae?a oaeiae
ca?eueooaaany o a??iee?a noa?oi? a?eiai? a?oie o ii??aiyii? c iniaaie
20-30 ?ie?a. ??aaiue AnAO iaa iaea?eueoa cia/aiiy o a?eia?e a?oi? 20-30
?ie?a (0,22±0.05 iiieue/e a), oa cieaeoaaany aei 0,15±0,02 iiieue/e a a
a?oi? 51-60 ?ie?a.

Aiae?c ci?i a caeaaeiino? a?ae noaaeo ?iaioe iieacaa, ui ai?no
caaaeueiiai a?eeo aoa i?i?iaeueiei i?e noaae? ?iaioe aei 5 ?ie?a
(66,15±2,1 a/e) oa c?inoaa aei iaeneioio i?e noaae? 21-25 ?ie?a
(73,61±2,0 a/e). Ai?no aeueaoi?i?a aoa oaeiae iaeiaioei o ?ia?oiee?a c?
noaaeai aei 5 ?ie?a (34,55±2,8) oa aeyaeyany ieae/ei iieaciee?a
noaaeiaeo a?oi 16-20 oa 21-25 ?ie?a. A/A eiao?oe??io o oaooa??a c?
noaaeai aei 5 ?ie?a, 5-10 ?ie?a oa 11-15 ?ie?a aoa ieae/a, i?ae i?e
noaae? 16-20 oa 21-25 ?ie?a. Oe? ci?ie iiaeooue aooe iia’ycai? c oei, ui
i?aai?ci iieiaeeo ?ia?oiee?a ua ia anoea aaeaiooaaoeny aei aaaeeeo oiia
i?aoe?. ??aaiue a-e?iii?ioa?ae?a c?inoaa c i?i?ioio i?e noaae? aei 5
?ie?a (20,4±2,3 iae.) aei iaeneioio i?e noaae? 21-25 ?ie?a (26,1±3,12
iae.; ?<0.05). Cia/aiiy AeAO cieaeoaaeiny c 0,22±0,07 iiieue/e a i?e noaae? aei 5 ?ie?a aei 0,16±0,027 iiieue/e a i?e noaae? 16-20 ?ie?a. A?aecia/aia c?inoaiiy ??aiy oieanoa?eio oa a-e?iii?ioa?ae?a ca a?eii oa ca?eueoaiiyi noaaeo ?iaioe ocaiaeaeo?oueny c caaaeueiia?aeiieie a?eiaeie ci?iaie e?i?aeiiai iai?io (N.Ae. Iiaeuiiaa, 1995). Ioaea, io?eiai? aeai? a?io?i?/iiai aeine?aeaeaiiy na?ae/eee i?i ae?aaeai? ii?ooaiiy ooieoe?? ia/?iee oa iiaeeeaa o?aaeaiiy aaiaoioeeo?a. O ca’yceo c oei, ui ia ooieoe?th ia/?iee ? ie?ie aieeaathoue ci?ie aaiiaeeiai?ee, o a??iee?a aoei ?icii/aoi aeine?aeaeaiiy noaio oeaio?aeueii? aaiiaeeiai?ee. I?e oeueiio anoaiiaeaii, ui o a??iee?a II a?oie, a ii??aiyii? c eiio?ieai, ia? i?noea cieaeaiiy ia’?iieo iieaciee?a aaiiaeeiai?ee: oaea?iiai ia’?io (OI; 52.33±1.14 ? 69.71±2.79 ie), oaea?iiai ?iaeaeno (O?; 29.54± 0.77 ? 43.77±1.77 ie/i2), oaeeeiiiai ia’?io e?iaiia?ao (OI; 3.93±0.11 ? 4.69±0.2 e/oa) ? na?oeaaiai ?iaeaeno (N?; 2.22±0.07 ? 2.79±0.13 e/oa/i2), a oaeiae oaeaee?nieo iieaciee?a aaiiaeeiai?ee: ia’?iii? oaeaeeino? aeeeaeo (IOA; 154.2±3.5 ? 224.8±8.1 ie/n) oa e?i?eii? oaeaeeino? ?ooo e?ia? (EO?E; 34.05±0.85 ? 52.34±2.0 ni/n). I?e oeueiio iiooaei?noue e?aiai oeoii/ea (N; 1.94±0.04 Ao) aoea cieaeaiith, a aeo?aoe aia?a?? ia ia?ai?uaiiy e?ia? (AA; 12.59±0.06 Ao/e) i?aeaeuaieie. Ii?yae c oeei, aeuei, i?ae a eiio?ieuei?e a?oi?, aoa caaaeueii ia?eoa?e/iee (CINI; 1999±53.8 ? 1559±76.0 aeei·ni-5·n) ? ieoiii ia?eoa?e/iee noaeeiiee ii?? (IINI; 45.02±1.3 oi. iae.). O a??iee?a III a?oie OI aoa aeuei, i?ae o a??iee?a II a?oie, aea ieae/ei, i?ae a eiio?ieuei?e a?oi?. O? o a??iee?a III a?oie aoa ieae/ei eiio?ieueii?, aea aeuei II a?oie. OI a III a?oi? aoa aeuei, i?ae a II a?oi?, ? ia a?ae??ciyany a?ae iieaciee?a eiio?ieth. IOA a III a?oi? aoea ieae/a eiio?ieueii?, aea aeua iieaciee?a II a?oie. EO?E aeyaeeanue ieae/ith, i?ae a eiio?ieuei?e a?oi? ? aeuith, i?ae a II a?oi?. N o a??iee?a III a?oie aoea ieae/a eiio?ieueii?, aea aeua II a?oie. AA o a??iee?a III a?oie, ia?aaeuoth/e eiio?ieuei? iieacieee, ia a?ae??ciyeeny a?ae aeaieo a II a?oi?. CINI oa IINI o a??iee?a III a?oie aoee ieae/a, i?ae o a??iee?a II a?oie ? ia?aaeuoaaee eiio?ieuei? iieacieee. Oaeei /eiii, o a??iee?a a?aei?/aeiny i?aeaeuaiiy CINI i?e cieaeaii? iiooaeiino? e?aiai oeoii/ea, ui i?eaiaeeei aei cieaeaiiy ye ia’?iieo, oae ? oaeaee?nieo iieaciee?a aaiiaeeiai?ee. A oe?eiio, oa?aeoa? aaiiaeeiai?/ieo ci?i o i?aecaiieo a??iee?a aoa?eueieo oaoo oa?aeoa?eco?oueny ye a?iieeiaoe/iee oei aaiiaeeiai?ee. I?e ca?eueoaii? aaaeeino? ?ia?o c?inoaa CINI, ui aaei aei ca?eueoaiiy aeo?aoe aia?a?? e?aiai oeoii/ea ia oii? cieaeaiiy eiai iiooaeiino? oa cieaeaiith ia’?iieo ? oaeaee?nieo iieaciee?a aaiiaeeiai?ee. Iiae?ai? aeai? aoee io?eiai? i?e aeine?aeaeaii? a?oi ?ia?oiee?a ?ioeo i?iieneiaeo i?aei?e?inoa (E.I.Aioiiee, 1989). I?e c?inoaii? a?eo ? noaaeo ?iaioe a i?aecaiieo oiiaao o i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo a?aeaoaaeiny ca?eueoaiiy ia?eoa?e/iiai noaeeiiiai iii?o i?e cieaeaii? iiooaeiino? e?aiai oeoii/ea oa ca?eueoaii? aeo?ao aia?a?? ia ia?ai?uaiiy e?ia?, ui i?ecaiaeeei aei cieaeaiiy ye ia’?iieo, oae ? oaeaee?nieo iieaciee?a aaiiaeeiai?ee. O ?ia?oiee?a ?ioeo i?ioan?eieo a?oi, i?aoey yeeo oaae iia’ycaia c o?ce/iei iaaaioaaeaiiyi, a?aeaoaaeiny ca?eueoaiiy ia’?iieo ? oaeaee?nieo iieaciee?a aaiiaeeiai?ee i?e cieaeaii? CINI, yea aecia/aeinue i?e noaae? ?iaioe aei 10 ?ie?a (TH.A.Ao?iae, 1996), ? eeoa iio?i niinoa??aaeiny iia??oaiiy aaiiaeeiai?ee. A?eia? ci?ie aaiiaeeiai?ee a?eueo?noth aeine?aeiee?a a?aei?/aeeny o in?a a?eii iiiaae 60 ?ie?a (A.A.Aocoiia, 1991), oiae? ye a iaoiio aeine?aeaeaii? iia??oaiiy aaiiaeeiai?ee anoaiiaeaii o a??iee?a a?eii iiiaae 30 ?ie?a, c? noaaeai iiiaae 10 ?ie?a. I?e/iio, ie?ai? iieacieee ci?ithaaeeny aaea i?e noaae? 5-10 ?ie?a. Iiaeeeai, ?icaeoie a?eueo ?aii?o ii?ooaiue aaiiaeeiai?ee o a??iee?a iaoiiaeaiee ni?aae??th o?ce/iiai iaaaioaaeaiiy oa aieeaii oaiea. Aeiaaaeaii, ui ?ioaineaia ia?aa??aaiiy i?eaiaeeei aei cieaeaiiy OI ca ?aooiie ciaioaiiy nei?i/oaaeueii? ooieoe?? i?iea?aeo oa aaiiciiai iiaa?iaiiy aei na?oey (A.O.Naaa/, 1993). Anoaiiaeai? ci?ie oeaio?aeueii? aaiiaeeiai?ee o a??iee?a iiaee aooe coiiaeai? ci?iaie ANI oa ?aaoethth/eo eiai nenoai - ?AAN, aacii?aneio, aiaeioae?io-1 ? ie?eiaei neioacii Pg. I?e aeine?aeaeaii? aene?aoi?ii? ooieoe?? ie?ie o i?aecaiieo a??iee?a anoaiiaeaii, ui a aacaeueiee ia??iae ??aaiue E+ (?E+) eieeaaany a?ae 3.9±0.06 aei 4.1±0.09 iiieue/e ? aoa ieae/a ca eiio?ieuei? iieacieee (4,27±0,12 iiieue/e). Oaeiae ieae/eie eiio?ieueieo aoee aeae?eaiiy oa ee??ain E+. A noeioeueiaaiee ia??iae ?E+ cieaeoaaany a I a?oi? (3.8±0.07 iiieue/e), aea caeeoaany ieae/ei eiio?ieth a I ? III a?oiao. A oeae aea ia??iae eiioeaio?aoe?y E+ a na/?, eiai aeae?eaiiy ? ee??ain i?aeaeuoaaany, iaeiae caeeoaany ieae/ei eiio?ieueieo iieaciee?a. Ia iiaeia aeeeth/eoe, ui cieaeaiiy ?E+ oaooa??a iia’ycaii c aaaeeith ?iaioith a oiiaao i?e?iee?iaoo, ui iaa??aa?. ??aaiue Na+ a e?ia? a iaeaeaa ia??iaee eieeaaany a iaaeao a?ae 133.3±1.1 aei 138.4±0.7 iiieue/e, ia a?ae??ciyth/enue i?e oeueiio iii?ae a?oiaie, oa aoa ieae/ei, i?ae eiio?ieuei? iieacieee (139,2±1,2 - 140.8±1.6 iiieue/e). A?aei?/ai? ci?ie ANI iiaeooue caeaaeaoe a?ae noaio ?AAN, ??aiy Vas ? neioaco Pg a ie?eao, ui ? iineoaeeei i?aenoaaith aei ?o aeine?aeaeaiiy. A?I aei oa i?ney ?iai/i? ci?ie aoea iaea?eueoith o ?ia?oiee?a II a?oie (3,6±0,53 e 3,89±0,62 ia/ie/a) ? ia?aaeuoaaea iieacieee eiio?ieueii? (2,29±0,33 ? 2,01±0,28 ia/ie/a) ? III a?oi. Ioaea, A?I aoea i?aeaeuaia ia o?eueee i?ney ?iaioe, ye iieacaii (C.Y.Guezennec, 1990) o in?a c aaaeeei o?ce/iei iaaaioaaeaiiyi, a ? a aacaeueiee ia??iae, ui iiaea aeyaeoeny ia?aaeoiiaith aeey aeieeiaiiy ?yaeo caoai?thaaiue na?oeaai-noaeeiii? oa na/iaeae?eueii? nenoai. Iiaeeeai, ui o in?a II a?oie i?aeaeuaiiy A?I iia’ycaii c i?aoeath a oiiaao i?e?iee?iaoo, ui iaa??aa? ? a?iien?? oa ii?aeio?oueny c i?aeaeuaiei ineoieia?/iei iaaaioaaeaiiyi (E.?.Aeii/aiei, 1988). A noeioeueiaaiee ia??iae, a ii??aiyii? c aacaeueiei, a eiio?ieuei?e ? III a?oiao a?aeaoaaeiny cieaeaiiy ??aiy ?A, oiae? ye a I a?oi? a?i nooo?ai ia ci?ithaaany, a a II a?oi? iaea i?noea oaiaeaioe?y aei ca?eueoaiiy. A ?acoeueoao? a?aei?/aieo ci?i ??aaiue ?A o in?a II a?oie i?ney ?iaioe (184,3±24,6 ia/ie) aeyaeany aeuee, i?ae a eiio?ieuei?e (99,5±11,9 ia/ie) ? III a?oiao. Cieaeaiiy ?A a eiio?ieuei?e, I ? III a?oiao a?aeiia?aeaei aeiaiaei ?eoiai ooieoe?iioaaiiy ?AAN (O.E.Eiia?ia, 1990; A.E.Neaaiia, 1989), oiae? ye o in?a II a?oie aeiaiaee ?eoi eaiaany. Iaaii, aeayea i?aeaeuaiiy ??aiy ?A iia’ycaii c ?aaeoe?yie i?aai?cio ia o?ce/ia iaaaioaaeaiiy (E.A.Oa?aaaa, 1995; M.E.Gunning, 1996). UA aei ?iai/i? ci?ie o a??iee?a I ? III a?oi aoa aeuee, i?ae a eiio?ieuei?e a?oi?. Ne?ae a?aecia/eoe, ui a noeioeueiaaiee ia??iae o ?ia?oiee?a III a?oie iecueeiio ??aith A a e?ia? a?aeiia?aeaa a?eueo aenieee ??aaiue A a na/?, yea, iiaeeeai, ? iaoiiaeea eiai cieaeaiiy. Oea i?eiouaiiy i?aeoaa?aeeeiny iiceoeaiith ei?aeyoe??th iii?ae ?A ? UA a ??? a?oi? oaooa??a. Aeae?eaiiy OoA2 c na/ath aei ?iai/i? ci?ie o a??iee?a III a?oie (269.6±18.1 ia/ie) ia?aaeuoaaei iieacieee a??iee?a II a?oie. A oie aea /an, a??ia?aeii? ??cieoe? iii?ae eiio?ieueiith a?oiith ? a?oiaie a??iee?a ia aoei. A noeioeueiaaiee ia??iae ??aaiue OoA2 ?ia?oiee?a i?aeoe/ii ia ci?ithaaany, a a eiio?ieuei?e a?oi? ciaiooaaany aaea?/?. Aiane?aeie oeueiai noeioeueiaaiee ??aaiue OoA2 o a??iee?a ia?aaeuoaaa iieacieee eiio?ieueii? a?oie. Aeae?eaiiy 6-eaoiPgF1 aei ?iai/i? ci?ie o an?o a?oiao oaooa??a aoei aaeai? aeua eiio?ieth (45,9±6,1 ia/ie). A noeioeueiaaiee ia??iae ??aaiue 6-eaoiPgF1 i?aeoe/ii ia ci?ithaaany, caeeoath/enue o oaooa??a aeuei eiio?ieueieo iieaciee?a, aac nooo?ai? ??cieoe? iii?ae a?oiaie. Aaee/eia ni?aa?aeiioaiiy OoA2/6-eaoiPgF1 a aacaeueiee ia??iae o a??iee?a I ? III a?oi ia a?ae??ciyeany a?ae iieaciee?a eiio?ieueii? a?oie, a a II a?oi? aoea iaioith, i?ae a eiio?ieuei?e ? III a?oiao. A noeioeueiaaiee ia??iae a eiio?ieuei?e ? III a?oiao aoei anoaiiaeaii ciaioaiiy ni?aa?aeiioaiiy OoA2/6-eaoiPgF1. ??aaiue aiaeioae?io-1 (A-1) a ieaci? e?ia? a??iee?a aoa iaea?eueoei o ?ia?oiee?a II a?oie, neeaaeaa 10,321,25 ia/ie ? ia?aaeuoaaa eiio?ieuei? iieacieee (?<0,05). Noaoenoe/ii cia/oui? ??cieoe? o ai?no? A-1 iii?ae a?oiaie ii??aiyiiy anoaiiaeaii ia aoei. I?e aiae?c? ei?aeyoeaieo ca’yce?a (?en. 1), a I oa a ?? a?oi? a??iee?a, ia a?aei?io a?ae eiio?ieueii? a?oie, aaea a aacaeueiee ia??iae a?aei?/aii, ui aeoeaaoe?y ?AAN aoea iia’ycaia ia c UE+ ? PNa+, a caeaaeaea a?ae ?E+. Oea iiaei aooe coiiaeaii oei, ui i?e o?ce/iiio iaaaioaaeaii? a ia?oo /a?ao a?aeaoaa?oueny ci?ia aaeaino E+ (H.J.Laragh, 1973). Ie??i oeueiai, i?aeneeth?oueny ?ieue OoA2 ? 6-eaoiPgF1 a nenoai? aca?iica’yceo, ui i?aeoaa?aeaeothoue aeai?, ye? aeacothoue ia c?inoaiiy ?ie? Pg a aeno?aiaeueieo oiiaao (H.A.Bock, 1995; G.C.Burns, 1997). A noeioeueiaaiee ia??iae o ?ia?oiee?a I a?oie aca?iica’ycie ?AAN ? neioaco Pg ua a?eueoa c?inoaa, ? oeaio?ii aca?iica’yceo noaaaa ia PgF2, ye a eiio?ieuei?e a?oi?, a nenoaia OoA2/6-eaoiPgF1. Ei?aeyoeai? ca’ycee o ?ia?oiee?a, ye? aeeiioaaee aaaeeo o?ce/io i?aoeth a iaeiani?eyoeeaeo oiiaao (II) aaaaoi a /iio aecia/aee ca’ycee, ui aoee anoaiiaeai? a I a?oi?, i?e oeueiio e?euee?noue ei?aeyoe?e ua a?eueoa c?inoaea. I?ae aieeaii aaaeei? o?ce/ii? i?aoe? ?AAN ae?yea ia ANI ia o?eueee i?yii, aea ? iiina?aaeeiaaii, /a?ac i?inoaii?aee. Oe?eaai a?aecia/eoe, ui o oaooa??a, aeeiioth/eo ?iaioe na?aaeiuei? aaaeeino?, (III), ciaiooaaeany e?euee?noue ei?aeyoeaieo ca’yce?a aei ??aiy eiio?ieth. Ioaea, iica aeno?aiaeueieie oiiaaie ?AAN, neioac Pg oa ANI a?eueo aaoiiiii? ? ia iio?aaothoue o?nii? aca?iiae?? aeey i?aeo?eioaaiiy aiiainoaco. Aaaeeeai a?aecia/eoe, ui i?e i?iaaaeaii? ianoaaeaiiy a??iee?a aoee aeyaeai? i?aeoe/ii caei?ia? iniae c aeieeiaiiyi ci?i o na/? i?ney ?iai/i? ci?ie. Oae, o 51 ?ia?oieea (3,2%) c’yaeyeanue i?ioa?io??y (aeueaoi?i 0,1-0,2 a/e) ? o 47 a??iee?a (2,9%) i?e?iaaiaoo??y (a?eo?ioeeoe 5-15106/e), iaoai?cie ?icaeoeo yeeo caeeoathoueny iaynieie. Aeey aea/aiiy ie?aieo iaoai?ci?a aeieeiaiiy iaaaaeaieo oaiiiai?a aoee a?ae?a?ai? aea? a?oie i?aeoe/ii caei?iaeo a??iee?a. I?e aiae?c? ci?i ?AAN, neioaco Pg a ie?eao, aacii?aneio oa ANI o 12 i?aeoe/ii caei?iaeo a??iee?a c iiyaith i?ioa?io??? i?ney ?iai/i? ci?ie anoaiiaeaii, ui o ?ia?oiee?a c II ?Na+ ? UNa+ a iaeaeaa ia??iaee aeine?aeaeaiiy aoee ieae/a, i?ae a eiio?ieuei?e a?oi? oa a a?oi? a??iee?a aac iaoieia?? a na/? (I a?oia). PCr ? UCr o ?ia?oiee?a c II a iaeaeaa ia??iaee aeine?aeaeaiiy aoee ieae/eie, i?ae o a??iee?a I a?oie. Ii?yae c oeei, nooo?aeo ci?i OEO o ?ia?oiee?a c II ia a?aeaoaaeiny. A oie aea /an i?aoey a aaaeeeo oiiaao iiaea i?ecaanoe aei cieaeaiiy ie?eiaiai e?iaiia?ao ? OEO (TH.I.Aoeaaa, 1989). A iaoiio aeine?aeaeaii? o a??iee?a ? a?oie ye aei, oae ? i?ney ?iai/i? ci?ie a?aei?/aany aenieee ??aaiue A?I. A oie aea /an, o a??iee?a c II a iaeaeaa ia??iaee niinoa?aaeaiiy A?I aoea ieae/a, i?ae a I a?oi?, ? ia a?ae??ciyeanue a?ae iieaciee?a A?I eiio?ieueii? a?oie. E??i oeueiai, o ?ia?oiee?a c II aoa anoaiiaeaiee ieae/ee aeo?aeiee ??aaiue ni?aa?aeiioaiiy OoA2/6-eaoiPgF1 ca ?aooiie ca?eueoaiiy aene?aoe?? 6-eaoiPgF1. A oie aea /an, a noeioeueiaaiee ia??iae a?aeaoaaeiny ca?eueoaiiy ni?aa?aeiioaiiy OoA2/6-eaoiPgF1 ca ?aooiie ??ceiai cieaeaiiy 6-eaoiPgF1 ? cia/ii aeuiai ??aiy aeae?eaiiy OoA2 (a 2.7 ?ace aeua eiio?ieth). Ii?yae c oeei, a aacaeueiee ia??iae anoaiiaethaaany cai?ioi?e ei?aeyoeaiee ca’ycie iii?ae 6-eaoiPgF1 oa ?Na+, a oaeiae iaaaoeaia ei?aeyoe?y OoA2 c UNa+, UVNa+ ? NNa+. A noeioeueiaaiee ia??iae aoea anoaiiaeaia i?yia ei?aeyoe?y 6-eaoiPgF1 a c UE+ ? UVE+. Aeoiaey/e c oeueiai, iiaeeeai, ui o ?ia?oiee?a c II aeey i?aeo?eiee ii?iaeueii? OEO aoee32 caae?yi? ?io? iaoai?cie. I?e oeueiio aaaaoi aoaeo?a ?AAN iiina?aaeeiaoaaeenue /a?ac nenoaio eieaeueiiai ie?eiaiai neioaco i?inoaii?ae?a. Ana oea aeicaiey? i?eionoeoe, ui o a??iee?a c II i?e aeeiiaii? iaeneiaeueiiai o?ce/iiai iaaaioaaeaiiy a iani?eyoeeaeo i?e?iee?iaoe/ieo oiiaao i?ia?aeio ?ieue a i?aeo?eiaii? ie?eiaiai e?iaiia?ao ia ii?iaeueiiio ??ai?, ii?yae c ?AAN, a?ae?a?athoue i?inoaii?aee, ye? ae?thoue, iaaii, iacaeaaeii a?ae inoaiiuei?. I?e oeueiio, a?aeiinia ca?eueoaiiy ??aiy OoA2 i?e cieaeaiiy aeae?eaiiy 6-eaoiPgF1, iiaeeeai, ni?ey? i?aeo?eioe? ie?eiaiai e?iaiia?ao ? OEO oa iiaea iaoiiaeoe aeieeiaiiy oaiiiaia II. Oea oe?eeii eiia??ii oaeiae ? oiio, ui aenieee ??aaiue OoA2 ei?aeth? c aaee/eiith i?ioa?io??? (R.F.Spurney, 1992; E.Nakabayashi, 1993). I?e aiae?c? ci?i ?AAN, neioaco Pg a ie?eao, aacii?aneio ? ANI o 21 a??ieea c iiyaeaiiyi aaiaoo??? i?ney ?iai/i? ci?ie (IA) anoaiiaeaii, ui o i?aeoe/ii caei?iaeo a??iee?a c IA aei ii/aoeo ?iaioe a?aecia/aeanue iecueea A?I oa aeniea OEO. I?e oeueiio niinoa??aaany iecueeee ??aaiue Na+ a na/? ? a?eueo aenieee NNa+. I?ney ?iai/i? ci?ie ?a?no?oaaany a?eueo iecueeee AO, a?aeaoaaeiny ??cea i?aeaeuaiiy A?I oa aeoeaaoe?y aacii?ani?ieo i?inoaii?ae?a, cie?aia OoA2, a oaeiae cieaeoaaany ?E+. Ie??i oiai, o in?a c IA, ia a?aei?io a?ae caaaeueii? a?oie a??iee?a, a?aeaoaaeiny iaeaea iiaia ?oeioaaiiy aca?iica’yce?a iii?ae ?AAN, neioacii Pg ? ANI, ui oaeiae iiaei aooe iaei??th c i?e/ei yaeu, ui niinoa??aaeeny (aeea. ?en. 1). ?en. 1 Ei?aeyoeai? ca’ycee iii?ae aeine?aeaeoaaieie iieacieeaie. A - aacaeuei? ei?aeyoe?? a I? a?oi?; A - noeioeueiaai? ei?aeyoe?? a I? a?oi?; N - aacaeuei? ei?aeyoe?? a V a?oi?; D - noeioeueiaai? ei?aeyoe?? a V a?oi? I?iaaaeai? ee?i?/i?, ?ino?oiaioaeuei?, a?io?i?/i? oa aaiiaeeiai?/i? aeine?aeaeaiiy, ci?ie ANI, ?AAN, neioaco Pg ? Vas na?ae/eee i?i ii?ooaiiy ooieoe?? ia/?iee ? ie?ie. Aiaeii/an, iaeiei ?c aaaeeeaeo /eiiee?a aeeaiei? aoa?eueii? oaooe, ui ae?thoue ia i?aai?ci ?ia?oiee?a, ? i?e?iee?iao, ui iaa??aa? [A.I.Aaeooeeia, 1996], yeee nooo?ai aieeaa? ia no?oeoo?o ? ooieoe?th ia/?iee oa ie?ie. A ca’yceo c oeei aoei ?icii/aoa aenia?eiaioaeueia aeine?aeaeaiiy aieeao ia?aa??aaiiy ia ii?oieia?/i? ci?ie oeaiei ia/?iee ? ie?ie. Ii?oieia?/ia aeine?aeaeaiiy ia/?iee uo??a aeyaeei, ui c? ca?eueoaiiyi o?eaaeino? ia?aa??ao, a?ae noaae?? ?ooiaiai caoaeaeaiiy (?C) aei noaae?? aaii?? (Aa), iineethaaeenue ci?ie a ia/?ioe?: c?inoaea iiaiie?iai?noue i?aaio, a?aecia/aeinue ?icoe?aiiy oeaio?aeueieo aai, iineethaaany ae?aiaaeac a?eo?ioeeo?a /a?ac no?ieo e?iaiiinieo noaeei, ca?eueooaaeeny ?ici??e ee?oei, ia?inoaee aeeno?io?/i? ci?ie a aaiaoioeeoao (A), c’yaeyeeny iae?ice ee?oei. E??i oiai, c?inoaea e?euee?noue aeaiyaea?ieo aaiaoioeeo?a oa eoioa?ianueeeo ee?oei, a a noaae?? Aa cia/ii ciaiooaaeanue. Cieaeoaaeany e?euee?noue i?oioiiae??e, aoaeiaa e?eno a ieo ii?oooaaeanue, ui a?aecia/aeinue oaeiae ?ioeie aeine?aeieeaie (I.A.Aeoiaaa, 1986). E??i oiai, a aiaeiieaciaoe/iiio ?aoeeoeoi? ciaiooaaeanue e?euee?noue oeenoa?i oa iia?eueii ?icoaoiaaieo ?eainii, aea ca?eueooaaeinue /enei e?i?aeieo a?aioe. Ia?inoaee yaeua aaeoieueii? aeeno?io??. A noaae?? Aa niinoa??aaeeny ee?oeie c iiai?noth e?ciaaiei neeaaeii c ii?ooaiith ieaciieaiith oa aeoiaeii neeaaeo ee?oeie a i?ino?? Ae?na. I?e aeaeo?iiii-a?noio?i?/iiio aeine?aeaeaii? a?aecia/aeany iineeaia a?ae noaae?? aei noaae?? aeaoi?iaoe?y, aaceeoeyoe?y oa o?aaiaioaoe?y e?cinii, oi?ioaaiiy c ieo aooioaainii, a oaeiae aca?iia ceeaaiiy oa ?iaeoeaaoe?y. A noaae?? Aa oe? ci?ie ia?a?inoaee a aecioeeoic neeaaeo e?cinii oa ?icn?thaaiiy e?ciniiaeueii? a?ae?ieace eiei e?i?aeieo e?aieei oa i?ae i?aaiaeaie. A oie aea /an, ?ioeie aaoi?aie i?e ia?aa??aaii? uo??a ia na?oeiaiio ??ai? aoei a?aecia/aii ca?eueoaiiy aeoeaiino? eenei? oinoaoace a on?o ciiao ia/?ieiai? aeieueee (C.ss.Aeieaiaa, 1989). A aia?ao? Aieueaeae? (AA) a?aecia/aeany c?inoath/a aaceeoeyoe?y c ?iciaaeii eiai oeenoa?i ia i?e?iiooe?oe? oa i?iaeoeoe??th iaeao?a e?iii?ioa?aeieo /anoie, aca?iiae?th/eo c e?ciniiaie oa ?o aecioeeoic. Iaaooue, ?ic?oeioaaiiy e?cinii oa aeyaeaiiy EO a oeeoiieaci? ee?oei oa i?inoi?? Ae?na aeyaeeinue i?e/eiith iioeiaeaeaiiy A. Ii?oieia?/ia aeine?aeaeaiiy ie?ie oaa?ei iieacaei, ui c iiaeiaaeaiiyi oaieiai? aeniiceoe?? i?e aino??e aenia?eiaioaeuei?e a?ia?oa?i?? niinoa??aaeenue cia/i? ci?ie eai?ey??a eeoai/e?a o aeaeyae? ?oeioaaiiy ?o aacaeueii? iaia?aie ? ii?ooaiiy no?oeoo?e aiaeioae?aeueieo ee?oei. Iaeaeeao? ci?ie a?aeaoaaeeny a ai?oae?? i?ieneiaeueieo eaiaeueoe?a (Ie), ui a?aei?/aii ? ?ioeie aeine?aeieeaie [I.C.Ie?o/ai, 1984]. Na?oeiiioe/ii oea aeyaeyeiny a c?inoaii? e?eueeino? eaiaeueoe?a c ??cei caoaeaiei ioai?ii [I.A.Aeoiaaa, 1986], ? ca?eueoaii? a ?o ee?oeiao iciae aaeoieueii? aeeno?io?? oa iae?ic?a. Aeaeo?iiiii?e?ineii?/ii a?aecia/aeeny ae?aaeai? ci?ie a yae?ao ee?oei, ?oeioaaiiy u?oeiai? ie?aeee ee?oei Ie, ci?ie a no?oeoo?? i?oioiiae??e, ui niinoa??aaeiny ? a ?ioeo aeine?aeaeaiiyo [O.A.Iaaeiaa, 1995]. Aeaeo?iiiia?noio?i?/i? aeine?aeaeaiiy aeicaieeee aeyaeoe cia/i? ii?ooaiiy e?ciniiaeueii-aaeoiey?iiai aia?aoa ee?oei (EAA), ye? i?iyaeeeny o?aaiaioaoe??th oa ?iaeoeaaoe??th e?cinii, oioaeueiith aaeoie?caoe??th AA, a oaeiae aeanoaa?e?caoe??th e?ciniiaeueieo iaia?ai aae aei ?o ?ic?eao ? aeoiaeo ai?noo e?cinii a oeeoiieacio ee?oei. Cia/i? ci?ie a aeenoaeueieo eaiaeueoeyo (Aee) niinoa??aaeeny o?eueee i?e o?eaae?e oaieia?e aeniiceoe??. I?e o?ii?/iiio ia?aa??aaii? aei noaae?? ?C ci?ie a ee?oeiao Ie aoee a?eueo aeeaieeie, i?ae i?e aino?iio, ? aeyaeyeeny a ca?eueoaii? e?eueeino? eaiaeueoe?a c iciaeaie aeeno?io??, cie?aia, aaeoieuei?e, oa e?eueeino? eaiaeueoe?a c iae?icaie, ui oaeiae a?aei?/aeiny ?ioeie iaoeiaoeyie [A.ss.Ieioeei, 1991]. I?e aeaeo?iiii-i?e?ineii?/iiio aeine?aeaeaii? niinoa??aaeiny ciaioaiiy e?eueeino? ? ii?ooaiiy no?oeoo?e i?aaiae ee?oei Ie oa i?i?iaeueii ae?aaeaieie ci?iaie a ee?oeiao Aee. Iaiao?aeii a?aecia/eoe, ui i?ioeane, ye? aeieeaee a ee?oeiao Ie i?e ia?aa??aaii?, aoee noiae? ?c ci?iaie a A. I?e ii??aiyii? aeaeo?iiiia?noio?i?/ieo ci?i a A ? ee?oeiao Ie aeyaeeiny, ui ci?ie a ee?oeiao Ie ia noaae?yo ?C ? oaieiaiai oaea?o (OO) aoee i?aeoe/ii iaeiaeiaeie. A AA Ie, ia a?aei?io a?ae A, o?aaiaioaoe?y oeenoa?i i?eaiaeeea aei oi?ioaaiiy a?eueo aaeeeeo aaeoieae, ui iaee ?ici??e aei 0,2 iei, i?e oeueiio aeoeai?noue EO a caa?aaeaieo nieiuaieo oeenoa?iao i?eai?/oaaeany. A A oaeiae a?aeaoaaeany oioaeueia o?aaiaioaoe?y AA, aea a?i nii/aoeo iaa a?eueo? ?ici??e oa o?eniaaio (a?e?a?iee iiethn) eieae?caoe?th. A oe?eiio, a iaaaaeai? no?iee a?ia?oa?i?? a ee?oeiao Ie, ye ? a A, a?aei?/aeany o?aaiaioaoe?y e?cinii ? cieaeaiiy ?o aeoeaiino?. Iaeiae a ee?oeiao ia/?iee oe? i?ioeane ioiiethaaee a iniiaiiio an? aeaee e?cinii, a a ee?oeiao Ie a?aeaoaaeany o?aaiaioaoe?y eeoa ai?eaeueieo. I?e oeueiio, o?aaiaioaoe?y AA aoea oa?aeoa?ia aeey iaio oei?a ee?oei, aea a?aeaoaaeany ii-?ioiio - oeyoii aaeoie?caoe?? a ee?oeiao Ie oa aaceeoeyoe?? (oi?ioaaii? ae??aieo iooe?oe?a) a aaiaoioeeoao. A oa?i?iaeuei?e noaae?? a ee?oeiao Ie, ia a?aei?io a?ae A, ia a?aei?/aeiny aecioeeoico e?ciniiaeueii? a?ae?ieace oa aeaci?aai?caoe?? oeeoiieacie. A ee?oeiao Ie ia aeyaeyeiny ? iciae e?i?aeii? aeeno?io?? a aeaeyae? a?aeeeaaeaiiy e?aieei iaeo?aeueiiai aee?o a oeeoiieaci? aai ?o aecioeeoico. Ioaea, iayai?noue ae?aaeaieo ci?i aene?aoi?ii? oa ?ie?aoi?ii? ooieoe?? ie?ie, a oaeiae iiyaa a ?yae? aeiaaee?a i?ioa?io??? oa aaiaoo??? iiaei aooe iaoiiaeaii ii?oieia?/ieie ci?iaie a ie?eao, ye? aeieeee i?e a?ia?oa?i??. sse iieacaii a aeaiiio aeine?aeaeaii? oa a ?yae? ?ioeo ?ia?o, i?e ia?aa??aaii? iaea?eueo? ci?ie ie?ie a?aeaoaathoueny a ae?eyioe? Ie [O.A.Iaaeiaa, 1993]. Iaea?eueo /?oea o?aaeaiiy Ie aecia/aeiny i?e aeaeo?iiiia?noio?i?/iiio aeine?aeaeaii? [TH.A.Ao?iae, 1996]. C iiaeiaaeaiiyi oa?i?io oaieiai? aeniiceoe?? a ee?oeiao Ie a?aeaoaaeany aeanoaa?e?caoe?y e?ciniiaeueieo iaia?ai, aae aei ?o ?ic?eao ? aeoiaeo ai?noo e?cinii a oeeoiieacio ee?oei. Naia c ii?ooaiiyi EAA iiaeia iia’ycaoe iiyaeaiiy iae?ic?a a ee?oeiao Ie, ui ia iiaei ia a?aeaeoeny ia aene?aoi?i?e ooieoe?? ie?ie, a ye?e aeoeaio o/anoue i?eeiathoue Ie [A.N.Na?ioeeoeueeee, 1995; G.Saccomani, 1990]. A?aoiaoth/e i?iaaaeai? ii?oieia?/i? aeine?aeaeaiiy ia/?iee ? ie?ie, iiaeia i?eionoeoe, ui aeiaaio?eaaea i?aoey a oiiaao i?e?iee?iaoo, ui iaa??aa?, aeeaieeo aoa?eueieo oaoo ? oaeoi?ii ?eceeo ?icaeoeo ooieoe?iiaeueieo, a iio?i ? i?aai?/ieo ci?i ia/?iee oa ie?ie, ye? i?eaiaeyoue aei ?icaeoeo ??cieo caoai?thaaiue. A ii?oieia?/iiio iioeiaeaeaii? ie?ie, a oaeiae ?ioeo i?aai?a, a inoaii?e /an aaeeeiai cia/aiiy iaaea?oueny i?ioeanai e?iiia?ieneaeaoe?? oa noaio nenoaie aioeieneaeaioiiai caoenoo (N.A.Aieiaaiia, 1995; ?.I.Aeoaea?, 1996; J.R.Diamond, 1992). O a?aeiia?aeiino? c oeei, o a??iee?a aoei i?iaaaeaii aeine?aeaeaiiy noaio IIE ? aeoeaiino? eeth/iaeo oa?iaio?a aioeieneaeaioiiai caoenoo - noia?ieneaeaeeniooace (NIAe) oa eaoaeace (EO). I?e oeueiio aeyaeeiny, ui o i?aecaiieo a??iee?a aoa?eueieo oaoo a oe?eiio (I a?oia), a ii??aiyii? c iieacieeaie eiio?ieueii? a?oie, anoaiiaeaii i?aeaeuaiiy ??aiy ae??iiaiai eii’thaaoa (AeE; 85.8±3.3 ? 158.3±8.3 ieiieue/e, a?aeiia?aeii) oa iaeiiiaiai ae?aeueaeaa?aeo (IAeA; 29.4±1.3 ? 41.1±1.7 ieiieue/e). Ii?yae c oeei, a?aei?/aii i?aeaeuaiiy aeoeaiino? EO (20.5±1.0 ? 41.3±1.5 ieao/aiae.e) oa oaiaeaioe?y aei i?aeaeuaiiy NIAe. O ?ia?oiee?a II a?oie, a ii??aiyii? c eiio?ieueieie iieacieeaie, anoaiiaeaii i?aeaeuaiiy ??aiy AeE ? IAeA. I?e oeueiio a?aei?/aii i?aeaeuaiiy aeoeaiino? EO ? aeoeaiino? NIAe. Nooo?ai? ??cieoe? iieaciee?a I ? III a?oie ia aoei anoaiiaeaii. Ai?no a ieaci? e?ia? AeE o ?ia?oiee?a III a?oie aoa ieae/ei, i?ae a II a?oi?. I?e aiae?c? a?eiaeo ci?i IIE ? aeoeaiino? oa?iaio?a aioeia?aeeniiai caoenoo aeyaeeiny, ui ??aaiue AeE aoa iaea?eueoee o iieiaeeo ?ia?oiee?a (181,113,5 ieiieue/e), i?ney /iai cieaeoaaany aei 134,618,3 ieiieue/e o in?a 51-60 ?ie?a (?<0,05). ??aaiue IAeA a e?ia? a??iee?a oaeiae aoa iaeneiaeueiei o in?a 20-30 ?ie?a (47,12,8 ieiieue), cieaeoaaany a a?oe? 31-40 ?ie?a (?<0,05), aeinyaath/e i?i?ioio a a?eia?e a?oi? 51-60 ?ie?a (39,22,4 ieiieue), c aeinoia??iith ??cieoeath c iieiaeoith a?eiaith a?oiith. Iaea?eueo? iieacieee EO aecia/aeeny o in?a 20-30 ?ie?a (45,62,6 ieao/aiaee), i?ney /iai a?aeaoaaeiny cieaeaiiy eiai o a??iee?a 31-40 ?ie?a ? nooo?ai ia ci?ithaaany a iiaeaeueoiio. I?e aiae?c? aieeao noaaeo ?iaioe a i?aecaiieo oiiaao ia noai IIE ? oa?iaio?a aioeia?aeeniiai caoenoo aeyaeeiny, ui iaea?eueoee ??aaiue AeE aecia/aany o oaooa??a ?c noaaeai aei 5 ?ie?a ? neeaaeaa 182,314,1 ieiieue/e, a iiaeaeueoiio cieaeoaaany aei i?i?ioio o a??iee?a c i?aecaiiei noaaeai 11-15 ?ie?a (134,79,3 ieiieue/e). Aaee/eia IAeA oaeiae aoea iaea?eueoith o a??iee?a c iaeei i?aecaiiei noaaeai (46,94,5 ieiieue/e) oa cieaeoaaeanue aei i?i?ioio i?e noaae? 11-15 ?ie?a (36,42,8 ieiieue/e; ?<0,05). ??aaiue EO oaeiae aoa iaea?eueoei o iaeinoaaeiaaieo ?ia?oiee?a (47,04,0 ieao/aiae·e), cieaeoaaany i?e noaae? 11-15 ?ie?a (37,52,9 ieao/aiae·e) oa ia ci?ithaaany a iiaeaeueoiio. ??aaiue NIAe iaa iaeneiaeueia cia/aiiy o ?ia?oiee?a c? noaaeai aei 5 ?ie?a, a iio?i cieaeoaaany i?e ca?eueoaii? noaaeo ?iaioe, i?e aeinoia??i?e ??cieoe? iii?ae noaaeiaeie a?oiaie 11-15 ? 21-25 ?ie?a. Oaeei /eiii, i?e ?icaeyaeaii? IIE ? aeoeaiino? oa?iaio?a aioeieneaeaioiiai caoenoo o a??iee?a aoei anoaiiaeaii cia/ia i?aeaeuaiiy ia?aeiieo (AeE) oa e?ioeaaeo (IAeA) i?iaeoeo?a IIE. Ca?eueoaiiy aeoeaiino? NIAe ? aaeaioeaiith ?aaeoe??th, ni?yiiaaiith ia ciaioaiiy IIE. A oie aea /an, i?aeaeuaiiy a ne?iaaooe? e?ia? aeoeaiino? aioo??ee?oeiiiai aiceio - EO - ? a?aeia?aaeaiiyi oeeoie?oe/iiai neiae?iio (A.I.Iaothoei, 1991), yeee ia? i?noea o ?ia?oiee?a "aa?y/iai" ae?iaieoeoaa (A.I.Iiaaaeueiiiay, 1994). I?e oeueiio, aeoeai?noue NIAe o a??iee?a II a?oie aoea aeaui aeuith, i?ae o a??iee?a III a?oie, oaeiae, ye ? ai?no AeE a ieaci? e?ia?. Oea noaei na?ae/aiiyi a?eueo aeniei? ?ioaineaiino? i?ioean?a IIE o a??iee?a II a?oie, ui, eiia??ii, iia’ycaii c? cia/ieie o?ce/ieie iaaaioaaeaiiyie, a?iien??th oa aieeaii i?e?iee?iaoo, ui iaa??aa?. Cacia/ai? ci?ie iiaeooue a?ae?a?aaaoe cia/io ?ieue o oi?ioaaii? iaoieia?? ia/?iee oa ie?ie (A.?. Eoeeeiaa, 1997). I?e oeueiio, aieeaii a?eueieo ?aaeeeae?a, ui aeieeee i?e aeoeaaoe?? IIE, /anoeiai iiaeia iiynieoe aeoeaaoe?th ?AAN o a??iee?a II a?oie (T.N.Meyer, 1996), cieaeaiiy neioaco PgI2 a ie?eao i?ney ?iai/i? ci?ie o a??iee?a V a?oie (H.Nakano, 1994), aeieeiaiiy i?ioa?io??? o a??iee?a i?ney ?iai/i? ci?ie, iiaeeeai, iaoiiaeaiith iioeiaeaeaiiyi aiaeioae?aeueieo ? ai?oae?aeueieo ee?oei eeoai/e?a ie?ie, ee?oei iacaia?y (T. Yoshioka, 199I; Duque, 1992), ia?aaaaeia ooeiaeaeaiiy Ie aiane?aeie a?eueo iecueeiai ??aiy (a ii??aiyii? c Aee) oa?iaio?a aioeieneaeaioiiai caoenoo, cie?aia NIAe (S.Kiyama, 1995). Ia aeeeth/aii, ui ii?ooaiiy iai?io aeaeo?ie?o?a o a??iee?a a?aeaoaaeiny aiane?aeie aeieoaaiiy Na+-E+-aaeaiic?ioinoaoace, yea aeieeaei i?e i?aeaeuaii? ?ioaineaiino? e?iiia?ieneaeaoe?? (D.Cemeric, 1995). I?e ?iciiae?eaii? a??iee?a a caeaaeiino? a?ae a?eo ? noaaeo ?iaioe a i?aecaiieo oiiaao anoaiiaeaii, ui ??aaiue on?o aea/a?ieo iieaciee?a aoa iaeneiaeueiei o ?ia?oiee?a o a?eia?e a?oi? 20-30 ?ie?a oa i?e noaae? ?iaioe aei 5 ?ie?a, ? a iiaeaeueoiio cieaeoaaany. Ii?yae c IIE, a iaoiaaiac? caoai?thaaiue aioo??oi?o i?aai?a aaaeeeaa i?noea caeiathoue ci?ie ?ioiii? nenoaie [A.I.O?ieia, 1998; S.D.Lee, 1995]. O a?aeiia?aeiino? c oeei, o a??iee?a aeeaieeo aoa?eueieo oaoo aoei i?iaaaeaii aea/aiiy ee?oeiiiai ? aoii?aeueiiai ?ioi?oaoo. I?e aea/aii? aieeao ?iaioe ia ?ioiiee noaoon aoei anoaiiaeaii, ui o a??iee?a I a?oie ciaiooaaeanue e?euee?noue eaeeioeeo?a (L) oa e?ioioeeo?a (E) ye a aaniethoieo, oae ? a a?aeiinieo iieacieeao (?<0,05). Ai?no O-e?ioioeeo?a (CD3), O-oaeia?ia (CD4) ? O-noi?ani??a (CD8) oaeiae aoa cieaeaiee (?<0,05). ?ioiiei?aaoth/ee ?iaeaen (CD4 /CD8) o a??iee?a neeaaeaa 1.31±0.07 ? aoa ieae/ei, i?ae a eiio?ieuei?e a?oi? (2.29+0.23). A?aeiiniee ai?no A-e?ioioeeo?a (CD22) o a??iee?a ca?eueooaaany (?<0,05), oiae? ye ?o aaniethoi? cia/aiiy aoee i?eaeecii iaeiaeia? a a?oiao ii??aiyiiy. Ai?no IgA, IgG ? IgM a e?ia? a??iee?a aoa cieaeaiee (?<0,05). A oie aea /an, ??aaiue oee?eoethth/eo ?ioiieo eiiieaen?a (Oe?E) aeyaeany i?aeaeuaiei (?<0,05). I?e aiae?c? a?eiaeo ci?i ?ioiiiai noaoono a??iee?a anoaiiaeaii, ui noaoenoe/ii aeinoia??ii c?inoaea eeoa a?aeiinia e?euee?noue CD3 i?e ca?eueoaii? a?eo c 31-40 aei 51-60 ?ie?a, a ai?no Oe?E cieaeoaaany a 41-50 ?ie?a a ii??aiyii? c ?ia?oieeaie 20-30 ?ie?a. Noaae ?iaioe a i?aecaiieo oiiaao a a?eueo?e i??? a?aeaeaaany ia noai? ?ioiiiai noaoono a??iee?a. Oae, a?aeiinia e?euee?noue CD3 c?inoaea c i?i?ioio i?e noaae? 5-10 ?ie?a (60,440,93%) aei iaeneioio i?e noaae? 21-25 ?ie?a (65,671,07%), c ??cieoeath iii?ae noaaeiaith a?oiith 21-25 ?ie?a ? a?oiaie aei 5 ?ie?a ? 5-10 ?ie?a. E?euee?noue CD4 o a?aeiinieo aaee/eiao c?inoaea c 32,41,6% i?e noaae? aei 5 ?ie?a aei 37,17 1,65% i?e noaae? 21-25 ?ie?a. CD8 o a?aeiinieo aaee/eiao cieaeoaaeinue a?ae 29,41,86% i?e noaae? aei 5 ?ie?a aei 24,811,2% i?e noaae? 11-15 ?ie?a. ?ioiiei?aaoth/ee ?iaeaen aoa i?i?iaeueiei o ?ia?oiee?a ?c noaaeai aei 5 ?ie?a (1,170,08), a iio?i ca?eueooaaany, neeaaeath/e i?e noaae? 21-25 ?ie?a 1,450,1 (?<0,05). ??aaiue IgA i?aeaeuoaaany o oaooa??a c? noaaeai 5-10 ? 11-15 ?ie?a, a ii??aiyii? c iaeinoaaeiaaieie ?ia?oieeaie. ??aaiue Oe?E o in?a ?c noaaeai 11-15 ?ie?a ? 21-25 ?ie?a aoa ieae/ee, i?ae o ?ia?oiee?a ?c noaaeai aei 5 ?ie?a. Io?eiai? ?acoeueoaoe ni?aiaaeaee c aeaieie aeine?aeaeaiue ?ioiiiai noaoono o ?ia?oiee?a i?iieneiaeo i?aei?e?inoa, ye? oa?aeoa?ecoaaeeny ?ioiiaeao?oeeoii: O-e?ioiiai??th, aeenaaeainii ?aaoeyoi?ieo noaiiioeyoe?e O-e?ioioeeo?a, i?eai?/aiiyi i?iaeoeoe?? aioeo?e, ca?eueoaiiyi Oe?E oa cieaeaiiyi aeoeaiino? iae?ioaaaeueii? oaaioeeoa?ii? nenoaie [A.ss.Ieioeei, 1998], ui, a oe?eiio, aecia/aeiny ye aoi?eiiee ?ioiiaeao?oeeoiee noai ca a?aeiinii a?ia?noi?ani?iei aa??aioii [?.N.Aaeaeao, 1996]. I?e oeueiio a?aecia/aiee ?ioiiaeai?aneaiee aieea o?ce/ieo iaaaioaaeaiue [A.I.Eyiei, 1993] oa i?e?iee?iaoo, ui iaa??aa? [A.N.Nieiaueaa, 1994]. Ne?ae i?aee?aneeoe, ui ?iciiae?e i?e aeine?aeaeaii? a??iee?a a caeaaeiino? a?ae a?eo ? noaaeo ?iaioe a i?aecaiieo oiiaao iieacaa i?aeoe/io a?aenooi?noue ci?i ?ioiiiai noaoono i?e ca?eueoaii? a?eo oa cia/i? ci?ie a?eueoino? iieaciee?a ?ioiia?aie i?e ?iciiae?e? a caeaaeiino? a?ae i?aecaiiiai noaaeo. Ci?ie ?ioiiiai noaoono oaooa??a iiaee aooe iia’ycai? c ii?ooaiiyie ?aaoeyoe?? ?ioi?oaoo. A ca’yceo c oeei aoea aea/aia ?ieue ai?iiio oeiono a1-oeiiceia ye iaeiiai c ?aaoeyoi??a ?ioiii? nenoaie. I?e ?iciiae?e? ?ia?oiee?a a caeaaeiino? a?ae aaaeeino? aeeiioaaieo ?ia?o anoaiiaeaii, ui ??aaiue a1O o an?o ianoaaeaieo a??iee?a aoa iaeaea aaea?/? ieae/ei, i?ae o in?a eiio?ieueii? a?oie (1,2010,186 ia/ie). Iaeiae iaea?eueoa cieaeaiiy a1O, a?aeiinii eiio?ieth, a?aei?/aeiny o ?ia?oiee?a II a?oie, aea eiai ??aaiue noaiiaea 0.600.08I ia/ie. Aiae?c a?eiaeo ci?i eiioeaio?aoe?? a1O iieacaa, ui ??aaiue a1O o in?a 51-60 ?ie?a neeaaeaa 0.597+0.16 ia/ie ? aoa ieae/ei, i?ae o a??iee?a a 20-30 ?ie?a. I?e c?inoaii? i?aecaiiiai noaaeo ??aaiue a1O cieaeoaaany c iaeneioio o ?ia?oiee?a ?c noaaeai aei 5 ?ie?a (1.030.19 ia/ie) aei i?i?ioio i?e noaae? 21-25 ?ie?a (0.5690.13 ia/ie). I?e i?iaaaeaii? ei?aeyoe?eiiai aiae?co iii?ae iieacieeaie a eiio?ieuei?e a?oi? noaoenoe/ii aeinoia??ieo cia/aiue ia anoaiiaeaii. Ei?aeyoe?eiee aiae?c a I a?oi? iieacaa, ui a1O iaa cai?ioio caeaaei?noue c aaee/eiith CD4 (r=-0,502; p<0.05) oa ?ioiiei?aaoth/ei ?iaeaenii (r=-0,438; p<0.05). I?e oeueiio aoa a?aei?/aiee i?yiee ca’ycie a1O c CD8 (r=0,465; p<0.05). E??i oiai, a1O ei?aethaaa c Oe?E (r=0,476; p<0.05). A III a?oi? onoaiiaethaaeeny cai?ioi? ei?aeyoe?? a1O c CD4 (r=-0,792; p<0.05) ? CD4 /CD8 (r=-0,663; p<0.05). Ioaea, o a??iee?a a1O iaa cai?ioio caeaaei?noue c O-oaeia?aie ? ?ioiiei?aaoth/ei ?iaeaenii oa i?yio c O-noi?ani?aie ? Oe?E. A oie aea /an, ca aeaieie ?yaeo aeine?aeiee?a, a1O ? ?a/iaeiith, yea noeioeth? O-oaeia?e a ?ac? aeo?aeiiai ineaaeaiiy ?ioi?oaoo [A.N.Oe?eineee, 1991]. Iiaeeeai, cieaeaiiy O-oaeia??a i?ecaiaeeoue aei noeioeyoe?? ae?iaee a1O. A oie aea /an, i?aeaeuaiiy ai?noo O-noi?ani??a, ye? iiaeooue aaeueioaaoe ooieoe?th O-oaeia??a, i?ecaiaeeoe aei noeioeyoe?? ae?iaeaiiy a1O aeey oiai, uia i?ioeae?yoe a?ae’?iiiio aieeao O-noi?ani??a ia O-oaeia?i? ee?oeie. Ca ?acoeueoaoaie aeanieo aeine?aeaeaiue, c o?aooaaiiyi i?iaaaeaiiai e?oa?aoo?iiai iaeyaeo iiaeia i?eionoeoe ianooiio noaio iaoiaaiaco ?icaeoeo caoai?thaaiue ia/?iee o a??iee?a aeeaieeo aoa?eueieo oaoo (?en. 2). Ia i?aai?ci oaooa??a aieeaa? eiiieaen iaoieia?/ieo /eiiee?a, a oiio /ene?: a?iien?y, a?ia?oa?i?y, no?an ? aeeiiaiiy aaaeeeo o?ce/ieo ?ia?o. Oe? oaeoi?e, ye ie?aii, oae ? a eiiieaen? aeeeeeathoue iineeaiiy IIE, aeoeaaoe?th oa?iaio?a aioeia?aeeniiai caoenoo, ii?ooaiiy ?ioiiiai noaoono ? aaiiaeeiai?ee. Iaiaaii, aeoeaaoe?y i?ioean?a IIE ? i?ia?aeiei oaeoi?ii a ?icaeoeo ci?i no?oeoo?e ia/?iee, ii?ooaiue ?ioiiiai noaoono ? a ?icaeoeo i?ioa?io??? iai?oaeaiiy. A?euei? ?aaeeeaee, ui i?e oeueiio ooai?ththoueny, ii?ooothoue ooieoe?iioaaiiy EAA a A. I?e oeueiio niinoa??aa?oueny aeanoaa?e?caoe?y e?ciniiaeueieo iaia?ai ? aeo?ae a?ae?ie?oe/ieo oa?iaio?a a oeeoiieacio A oa ca iaae? ee?oei. Ii?ooaiiy ?iaioe EAA aeeeeea? iioeiaeaeaiiy A ? ianooiia ii?ooaiiy e?i?aeiiai ? a?eeiaiai iai?io, ye? a naith /a?ao i?aeneeththoue iioeiaeaeaiiy aaiaoioeeo?a. Ii?ooaiiy e?i?aeiiai ? a?eeiaiai iai?io iiaea aeieeiooe aaciina?aaeiuei i?ae aieeaii oe?aeeeaeo /eiiee?a i?aecaiiiai na?aaeiaeua oa iineeeoeny c ao?aoith aeueaoi?i?a o ca’yceo c ?icaeoeii i?ioa?io??? iai?oaeaiiy. Aaaeeeai a?aecia/eoe oa, ui anoaiiaeai? a oiae? aeine?aeaeaiiy ci?ie oeaio?aeueii? aaiiaeeiai?ee o a??iee?a, cie?aia, i?aeaeuaiiy CINI, aeeeeeathoue ii?ooaiiy i?e?ioee?eoeyoe?? a ee?oeiao ia/?iee ? oei naiei ni?eythoue ?icaeoeo a ieo iae?ioe/ieo i?ioean?a. Ne?ae i?aee?aneeoe, ui ci?ie ?ioiiiai noaoono a??iee?a, ye? a?aeaoaathoueny i?e ?iaio? a oiiaao aeeaiei? aoa?eueii? oaooe, i?aeneeththoueny ii?ooaiiyie e?i?aeiiai ? a?eeiaiai iai?io, a oaeiae aeoeaaoe??th IIE. I?e oeueiio aeyaey?oueny ?ioiiaeao?oeeoiee noai ca a?aeiiniei a?ia?noi?ani?iei oeiii. ?en. 2. Noaia iaoiaaiaco ?icaeoeo caoai?thaaiue ia/?iee o a??iee?a aeeaieeo aoa?eueieo oaoo. Oaeei /eiii, ae?y oe?aeeeaeo /eiiee?a aeeaiei? aoa?eueii? oaooe i?ecaiaeeoue aei ii?ooaiiy ?ioiiiai noaoono ? aaiiaeeiai?ee, aeoeaaoe?? IIE c ianooiieie ci?iaie ooieoe?iioaaiiy EAA, ye? aeeeeeathoue iioeiaeaeaiiy aaiaoioeeo?a ? cia/i? ii?ooaiiy e?i?aeiiai ? a?eeiaiai iai?io. Ana oea noai?th? oiiae aeey ?icaeoeo caoai?thaaiue ia/?iee. I?iaaaeaia aeine?aeaeaiiy ?ia?oiee?a c aeieeiaiiyi i?ioa?io??? i?ney ?iai/i? ci?ie oa e?oa?aoo?i? aeai? aeicaieythoue i?eionoeoe ianooiio noaio iaoiaaiaco ?icaeoeo i?ioa?io??? iai?oaeaiiy o a??iee?a aeeaieeo aoa?eueieo oaoo (?en. 3). ?en. 3. Noaia iaoiaaiaco ?icaeoeo i?ioa?io??? iai?oaeaiiy o a??iee?a aeeaieeo Aeeiiaiiy aaaeeeo o?ce/ieo ?ia?o a oiiaao i?e?iee?iaoo, ui iaa??aa?, a?iien?? ? no?ano aaaea aei ii?ooaiue ANI, ?AAN, ii?ooaiue aaiiaeeiai?ee ? aeoeaaoe?? IIE. Aeoeaaoe?y ?AAN, yea aeieea? aiane?aeie ci?i aaiiaeeiai?ee ANI, a naith /a?ao i?aeneeth? ii?ooaiiy aaiiaeeiai?ee. Aeoeaaoe?y IIE, ui aeieea? i?ae aieeaii oe?aeeeaeo /eiiee?a i?aecaiiiai na?aaeiaeua, oaeiae aeeeeea? ii?ooaiiy aaiiaeeiai?ee. A oie aea /an, aeoeaaoe?y IIE a noeoiiino? c ii?ooaiiyie aaiiaeeiai?ee, a oaeiae a?ia?oa?i?y - aaciina?aaeiuei, i?eaiaeyoue aei ii?ooaiiy ooieoe?iioaaiiy EAA a ee?oeiao i?ieneiaeueieo eaiaeueoe?a ie?ie (Ie). I?ae aieeaii /eiiee?a i?aecaiiiai na?aaeiaeua ? aiane?aeie ii?ooaiue ANI ca?eueoo?oueny ??aaiue aiaeioae?io-1 (A-1) a ieaci? e?ia?. C ?ioiai aieo, ii?ooaiiy ANI ? aeoeaaoe?y ?AAN i?eaiaeyoue aei ci?ie neioaco Pg a ie?eao. Aeoeaaoe?y i?inoaii?ae?a (ye?, iiaeeeai, ? iina?aaeieeaie aaciaeoeaiiai aieeao ?AAN a ie?eao) a?aeaoaa?oueny, a iniiaiiio, ca ?aooiie aacieiino?eeoi?ieo noanoaioe?e, cie?aia OoA2. I?e oeueiio, ni?aa?aeiioaiiy OoA2 /PgI2 - ca?eueoo?oueny. I?aeaeuaiiy ??aiy A-1 ? OoA2 ua a?eueo i?aeneeth? ii?ooaiiy aaiiaeeiai?ee. E??i oiai, aeoeaaoe?y IIE i?eaiaeeoue aei iioeiaeaeaiiy ia/?iee, c aeieeiaiiyi ii?ooaiue a?eeiaiai ? e?i?aeiiai iai?io. Iaeii/anii, ii?ooaiiy e?i?aeiiai iai?io aeeeeea? ci?ie iaoaaie?cio a?ao?aeiiiai? eeneioe c ia?aaaaeiei ciaioaiiyi neioaco aaciaeeeyoaoi?ieo i?inoaii?ae?a, cie?aia, PgI2. A?aei?/aia iniaeea?noue i?eaiaeeoue aei ua a?eueoiai c?inoaiiy ?iaeaeno OoA2 /PgI2. A ca’yceo c oeei, i?ioeane, ui a?aeaoaathoueny a i?aai?ci? ?ia?oiee?a a oiiaao aeeaiei? aoa?eueii? oaooe, i?eaiaeyoue aei ??ceiai ca?eueoaiiy neioaco OoA2 ? A-1, a oaeiae ii?ooaiiyi ooieoe?iioaaiiy EAA Ie. Iiaeaeueoa i?aeaeuaiiy ??ai?a OoA2 ? A-1 i?eaiaeeoue aei nei?i/aiiy aiaeioae?aeueieo ee?oei eeoai/e?a ie?ie c ianooiiei ca?eueoaiiyi o?eueo?aoe?eieo ii?, i?aeaeuaiith oiiono aoa?aioieo a?oa??ie ? aioo??oiueieeoai/eiaiai oeneo. A?aei?/ai? aoaeoe i?ecaiaeyoue aei ca?eueoaiiy e?eueeino? a?eeo, ui o?eueo?o?oueny. O oie aea /an, i?iaaaeai? aenia?eiaioaeuei? aeine?aeaeaiiy aieeao a?ia?oa?i?? ia no?oeoo?o ie?ie i?iaeaiiino?oaaee cia/ia ii?ooaiiy ooieoe?iioaaiiy EAA ee?oei Ie c aeanoaa?e?caoe??th e?ciniiaeueieo iaia?ai, aeoiaeii ai?noo e?cinii a oeeoiieacio ee?oei oa aeieeiaiiyi iae?ic?a. Aaaeeeai a?aecia/eoe e oa, ui aeyaeai? a oiae? aeine?aeaeaiiy ci?i oeaio?aeueii? aaiiaeeiai?ee o a??iee?a, cie?aia, i?aeaeuaiiy CINI aeeeeea? ii?ooaiiy i?e?ioee?eoeyoe?? a ee?oeiao Ie ? oeei naiei ni?ey? ?icaeoeo a ieo iae?ioe/ieo i?ioean?a. E??i oiai, ii?ooaiiy e?i?aeiiai ? a?eeiaiai iai?io oaeiae i?eaiaeyoue aei iioeiaeaeaiiy Ie. A?aei?/aia iioeiaeaeaiiy Ie iaieio/a i?eaiaeeoue aei cieaeaiiy ?aaani?aoe?? a?eeo. Oaeei /eiii, i?ioeane, ui a?aeaoaathoueny a i?aai?ci? a??iee?a aeeaieeo aoa?eueieo oaoo, i?eaiaeyoue aei aaiiaeeiai?/ieo oa a?io?i?/ieo c?ooaiue, ye? aeeeeeathoue i?aeaeuaiiy ??aiy A-1, neioaco OoA2 a ie?eao oa iioeiaeaeaiith Ie. Iioeiaeaeaiiy Ie oa ie?eia? aoaeoe A-1 ? OoA2 i?eaiaeyoue aei i?aeaeuaiiy o?eueo?aoe?? a?eeo oa cieaeaiith eiai ?aaani?aoe??, ui a e?ioeaaiio ?acoeueoao? i?iyaey?oueny i?ioa?io???th iai?oaeaiiy. Cia/ia ciaioaiiy ??aiy aeueaoi?i?a, ii?ooaiiy ooieoe?? ia/?iee, ci?ie ANI ? ?AAN, oeaio?aeueii? aaiiaeeiai?ee, aeieeiaiiy i?ioa?io??? iai?oaeaiiy, ii?oieia?/i? ci?ie ia/?iee ? ie?ie, a oaeiae cia/i? a?aeoeeaiiy a ?ioiiiio noaoon? aeiaaaee ?ic?iaee i?io?eaeoe/ieo oa e?eoaaeueieo caoiae?a. C oe??th iaoith o a??iee?a aeei?enoiaoaaeany a?eeiaa a?oai?iii-i?ia?aeueia oa?/iaa aeiaaaea “Ni??oe?ia”, ?ioiiei?aeoi? “Ai?cii” ? aaiaoii?ioaeoi? “Aio?aeue”. I?ney i?iaaaeaiiai eo?no e?eoaaiiy a?oai?iii-i?ia?aeueiith aeiaaaeith "Ni??oe?ia" ??aaiue AeE oa aaee/eia IAeA o a??iee?a ciaiooaaeenue ? ia ia?aaeuoaaee iieaciee?a eiio?ieueii? a?oie. Aeoeai?noue EO i?ney e?eoaaiiy ciaioeeanue, aea ana ae oaee caeeoaeanue a?eueoith, i?ae a eiio?ieuei?e a?oi?. I?e aeine?aeaeaiiy ?ioiiiai noaoono o a??iee?a i?ney eo?no e?eoaaiiy oa?/iaith aeiaaaeith "Ni??oe?ia" aeyaeeiny, ui ai?no L ? E a e?ia? ca?eueoeany ? aaea ia a?ae??ciyany a?ae eiio?ieueiiai ??aiy. Ai?no CD3 o a??iee?a i?aeaeueany, aea ana ae oaee caeeoaany ieae/ei iieaciee?a eiio?ieueii? a?oie o a?aeiinieo aaee/eiao. Ai?no CD4 a e?ia? ca?eueoeany. Iaeiae, ??cieoey ca ai?noii CD4 o a?aeiinieo aaee/eiao iii?ae a?oiith a??iee?a i?ney e?eoaaiiy ? eiio?ieai caeeoaeanue. Ai?no CD8 a aaniethoieo oeeo?ao ca?eueooaaany, oiae? ye a?aeiini? iieacieee i?aeoe/ii ia ci?ithaaeeny. Ni?aa?aeiioaiiy CD4 /CD8 i?ney e?eoaaiiy aeinoia??ii ca?eueooaaeiny, aea ??cieoey c eiio?ieueiith a?oiith caeeoaeanue. Ai?no CD22 c?inoaa a aaniethoieo iieacieeao. Ai?no IgI ? IgA a e?ia? ca?eueooaaany ? aaea ia a?ae??ciyany a?ae eiio?ieueieo aaee/ei. ??aaiue Oe?E a e?ia? aeinoia??ii cieaeoaaany ? anoaiiaethaaany ia ??ai? eiio?ieueieo iieaciee?a. ??aaiue a1O aeinoia??ii c?inoaa i?ney e?eoaaiiy ? aaea ia a?ae??ciyany a?ae eiio?ieueieo iieaciee?a. Oaeei /eiii, canoinoaaiiy a?oai?iii-i?ia?aeueii? aeiaaaee "Ni??oe?ia" ni?aaeyei cia/io iiceoeaio ae?th ia IIE ? nenoaio aioeieneaeaioiiai caoenoo. I?e oeueiio iie?aueeeny i?aeoe/ii an? iieacieee ?ioiia?aie. I?ioa, ?yae c ieo caeeoaany ieae/a eiio?ieueieo. Iaiao?aeii a?aecia/eoe, ui o a??iee?a, ye? io?eioaaee oa?/iao aeiaaaeo "Ni??oe?ia" i? a iaeiiio c aeiaaee?a ia niinoa??aaeiny i? i?ioa?io???, i? aaiaoo??? i?ney ?iai/i? ci?ie. Iiaeeeai, ui i?inoaaeaiaeeiiaee oeyo i?aeo?eiee ie?eiaiai e?iaiia?ao ? OEO ca ?aooiie aenieiai ??aiy OoA2 iiaea ni?eyoe iiya? oaiiiaio i?ioa?io??? iai?oaeaiiy ? aaiaoo??? i?ney iaaaioaaeaiiy. Oea oei a?eueo ?iia??ii ua e oiio, ui "Ni??oe?ia", ca ?aooiie i?enooiino? a ?? neeaae? aioeieneaeaio?a, cieaeo? neioac OoA2 (A.A.Nanji, 1994). Canoinoaaiiy i?aia?aoo "Ai?cii" i?ecaiaeeei aei cieaeaiiy aaee/eie IAeA, i?e oeueiio ??cieoey c eiio?ieueiith a?oiith aeyaeeanue iacia/iith. Aeoeai?noue EO i?ney e?eoaaiiy nooo?ai ciaiooaaeanue, aea ana ae oaee caeeoaeanue a?eueoith, i?ae a eiio?ie?. I?e aeine?aeaeaii? ?ioiiiai noaoono o a??iee?a i?ney eo?no e?eoaaiiy ai?ciiii a?aei?/aii ca?eueoaiiy L ? E. Ai?no CD3 c?inoaa a aaniethoieo aaee/eiao, aea caeeoaany ieae/ei a?ae eiio?ieueieo iieaciee?a. ??aaiue CD4 ca?eueooaaany, iaeiae oaae caeeoaany ieae/a eiio?ieth. Ni?aa?aeiioaiiy CD4 /CD8 c?inoaei, aea caeeoaeiny ieae/a eiio?ieueieo iieaciee?a. Ai?no IgI a e?ia? ca?eueooaaany ? aaea ia a?ae??ciyany a?ae eiio?ieth. ??ai? IgG ? IgA caeeoaeeny ieae/eie ca iieacieee eiio?ieueii? a?oie. Ai?no Oe?E a e?ia? a??iee?a i?ney e?eoaaiiy ciaiooaaany, aea caeeoaany aeuei eiio?ieueieo iieaciee?a. Oaeei /eiii, canoinoaaiiy i?aia?aoo ni?eyei nooo?aiio iie?aoaiith a?eueoino? c iieaciee?a ?ioiiiai noaoono, ii?iae?caoe?? i?ioean?a IIE oa aioeieneaeaioiiai caoenoo. I?ney eo?no e?eoaaiiy i?aia?aoii "Aio?aeue" aeyaeeiny, ui ai?no IAeA ? aeoeai?noue EO cieaeoaaeeny. I?e oeueiio, ai?no AeE, IAeA ? aeoeai?noue EO caeeoaeeny aeueie, i?ae a eiio?ieuei?e a?oi?. Ai?no CD4 ca?eueooaaany a aaniethoieo iieacieeao, ui aieeioei ia c?inoaiiy ni?aa?aeiioaiiy CD4 /CD8. E??i oiai, anoaiiaeaii ca?eueoaiiy ai?noo CD22 a aaniethoieo iieacieeao. Ai?no L, E, CD3, CD4, CD8 ? ni?aa?aeiioaiiy CD4 /CD8 a e?ia? aoee ieae/a eiio?ieueiiai ??aiy, a ??aaiue CD22 aoa aeuee o a?aeiinieo aaee/eiao. Ai?no IgI ? IgA ca?eueooaaany ? ia a?ae??ciyany a?ae eiio?ieth, a IgG caeeoaany ieae/a iieaciee?a eiio?ieueii? a?oie. Ai?no Oe?E ciaiooaaany, aea caeeoaany aeua eiio?ieueieo iieaciee?a (?<0,05). Oaeei /eiii, canoinoaaiiy i?aia?aoo "Aio?aeue" i?ecaaei aei iie?auaiiy ?yaeo iieaciee?a ?ioiia?aie oa i?ioean?a IIE. I?ioa, ii?iae?caoe?y ia?aiao??a, a?aeaoaaeany eeoa ii ie?aiei iieacieeai, a i?ioeane IIE ? aeoeai?noue oa?iaio?a aioeieneaeaioiiai caoenoo ia aeinyaaee ii?ie ca aeiaeiei c iieaciee?a, ui aecia/aeeny. Ana aeuaiaaaaeaia aeicaiey? ?aeiiaiaeoaaoe i?aia?aoe “Ni??oe?ia”, “Ai?cii” ? “Aio?aeue” ye e?eoaaeueii-i?io?eaeoe/i? caniae o a??iee?a aeeaieeo aoa?eueieo oaoo. A E N I I A E E: 1. Aaaeea o?ce/ia i?aoey a oiiaao i?e?iee?iaoo, ui iaa??aa?, aeeaiei? aoa?eueii? oaooe i?eaiaeeoue aei ?icaeoeo ii?ooaiue ooieoe?? ia/?iee, ye? aeyaeythoueny cieaeaiiyi ai?noo caaaeueiiai a?eeo ? aeueaoi?i?a a ne?iaaooe? e?ia?, i?aeaeuaiiyi ??aiy AeAO, oieanoa?eio ? -e?iii?ioa?ae?a 2. O i?aeoe/ii caei?iaeo i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo a?eii iiiaae 30 ?ie?a, i?e noaae? ?iaioe iiiaae 15 ?ie?a aeieeathoue ii?ooaiiy oeaio?aeueii? aaiiaeeiai?ee, ye? aeyaeythoueny i?aeaeuaiiyi caaaeueii ia?eoa?e/iiai noaeeiiiai iii?o, cieaeaiiyi iiooaeiino? e?aiai oeoii/ea, ia’?iieo ? oaeaee?nieo iieaciee?a i?e c?inoaii? ci?i o ca’yceo c? ca?eueoaiiyi aaaeeino? ?ia?o. 3. I?aoey a oiiaao aeeaiei? aoa?eueii? oaooe aaaea aei ii?ooaiiy iai?io aeaeo?ie?o?a, aeoeaiino? ?AAN ? aene?aoe?? Pg, ui aeyaey?oueny: cieaeaiiyi ??ai?a E+ ? Na+ ieacie e?ia?, i?aeaeuaiiyi ??aiy e?aaoei?io na/? (a aacaeueiee ia??iae) aac caeaaeiino? a?ae aaaeeino? i?aoe? ? oace aeine?aeaeaiiy; i?aeaeuaiiyi A?I, aene?aoe?? 6-eaoiPgF1 ye aei, oae ? i?ney ?iai/i? ci?ie, ca?eueoaiiyi ??ai?a aeueaeinoa?iio a ieaci? e?ia? ? OoA2 a na/? i?ney ?iai/i? ci?ie; ca?eueoaiiyi e?eueeino? ei?aeyoeaieo ca’yce?a iii?ae ?AAN, aene?aoe??th Pg ? ANI (14 cai?noue 6 a eiio?ieuei?e a?oi?) o in?a iniiaieo i?ioan?e. 4. ??aaiue aiaeioae?io-1 i?aeaeuo?oueny o in?a, ui aeeiiothoue aaaee? ?iaioe a iaeiani?eyoeea?oeo oiiaao a??ie/eo ae?iaie. 5. ?icaeoie i?ioa?io??? iai?oaeaiiy o i?aeoe/ii caei?iaeo i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo iia’ycaiee c? cieaeaiiyi aeoeaiino? ?ai?io ieacie ? aeueaeinoa?iio ieacie e?ia?, iaae?iiyi i?aeaeuaiiai ??aiy aene?aoe?? 6-eaoiPgF1 ? ca?eueoaiiyi ni?aa?aeiioaiiy OoA2/6-eaoiPgF1, i?e cieaeaiiio ??ai? Na+ ieacie e?ia?, e?aaoei?io ieacie e?ia? ? na/?. 6. Aaiaoo??y i?ney iaaaioaaeaiiy o a??iee?a aeieea? ia oii? cieaeaiiy ii/aoeiai aeniei? OEO, ??ceiai i?aeaeuaiiy aeoeaiino? ?ai?io ieacie ? aeae?eaiiy OoA2, ye? noi?iaiaeaeothoueny cieaeaiiyi E+ ieacie e?ia?, e?aaoei?io ieacie e?ia? ? Na+ na/? oa cieeiaiiyi ei?aeyoeaieo ca’yce?a iii?ae aeine?aeaeoaaieie ?aaoeyoi?ieie nenoaiaie. 7. Ia?aa??aaiiy aenia?eiaioaeueieo oaa?ei i?eaiaeeoue aei ?icaeoeo aeeno?io?/ieo ci?i oa iae?ic?a a aaiaoioeeoao ? ee?oeiao i?ieneiaeueieo eaiaeueoe?a ie?ie, iaea?eueo ae?aaeaieo i?e o?ii?/iiio ia?aa??aaii?. Iaoai?ci ooeiaeaeaiiy i?aai?a iieyaa? a ii?ooaii? ?iaioe e?ciniiaeueii-aaeoiey?iiai aia?aoo ee?oei, aeanoaa?e?caoe?? e?ciniiaeueieo iaia?ai ? aeoiae? oa?iaio?a a oeeoiieacio oa ca iaae? ee?oei. 8. O i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo anoaiiaeaii i?aeneeaiiy i?ioean?a IIE ? i?aeaeuaiiy aeoeaiino? oa?iaio?a aioeieneaeaioiiai caoenoo, a?eueo ae?aaeaia o ?ia?oiee?a, ye? aeeiiothoue aaaee? ?iaioe a iaeiani?eyoeea?oeo oiiaao i?aecaiieo ae?iaie. 9. O i?aeoe/ii caei?iaeo i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo a?aei?/a?oueny cia/ia aeai?an?y ee?oeiii? oa aoii?aeueii? eaiie ?ioi?oaoo c ?icaeoeii ?ioiiaeao?oeeoiiai noaio ca a?aeiinii a?ia?noi?ani?iei aa??aioii. 10. Ci?ie ?ioiiiai noaoono i?aecaiieo a??iee?a aeeaieeo aoa?eueieo oaoo i?aeoe/ii ia caeaaeaoue a?ae a?eo oaooa??a ? iia’ycai? c? noaaeai ?iaioe a i?aecaiieo oiiaao. 11. A ?icaeoeo ?ioiiaeao?oeeoiiai noaio o a??iee?a aa?a o/anoue ai?iii oeiono a1-oeiicei. ??aaiue a1-oeiiceio o a??iee?a cia/ii cieaeo?oueny, i?e/iio a a?eueo?e i??? o in?a, ui aeeiiothoue aaaee? ?iaioe a iaea?eueo iani?eyoeeaeo oiiaao a??ie/eo ae?iaie. 12. A?oiith ?eceeo ? iaea?eueo noeeuei? aei ae?? oe?aeeeaeo /eiiee?a aeeaiei? aoa?eueii? oaooe iieiae? ?ia?oieee (20-30 ?ie?a) oa iniae c iaaaeeeei noaaeai (aei 5 ?ie?a). Oea i?aeoaa?aeaeo?oueny iaeieae/eie iieacieeaie caaaeueiiai a?eeo ? aeueaoi?i?a, CD4 ? IgA, a oaeiae i?aeaeuaiiyi AeE, IAeA, EO, a?aeiinii? e?eueeino? CD8 ? Oe?E. 13. Aeei?enoaiiy oa?/iai? aeiaaaee “Ni??oe?ia”, ?ioiiei?aeoi?a “Ai?cii” ? aaiaoii?ioaeoi?a “Aio?aeue” o a??iee?a aeeaieeo aoa?eueieo oaoo i?eaiaeeoue aei cieaeaiiy ?ioaineaiino? i?ioean?a IIE, aeoeaiino? oa?iaio?a aioeieneaeaioiiai caoenoo, iie?auaiith iieaciee?a ?ioiiiai noaoono oa ?aeiiaiaeo?oueny aeey i?io?eaeoe/iiai e?eoaaiiy. NIENIE I?AOeUe, UI IIOAE?EIAAI? CA OAIITH AeENA?OAOe?? 1. ?aa?ia A.A. Ia?ooaiey ooieoeeiiaeueiiai ninoiyiey i?aaiia e nenoai o ai?ii?aai/eo.- Eoaaine, AAO “EIAe”, 1998.- 180 n. 2. ?aa?ia A.A. ?aiei-aiaeioaicei-aeueaeinoa?iiiaay nenoaia. Iniiau oeceieiaee. / Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia // Eoaaine, “Eoaaiue”, 1998, n.36-44. 3. ?aa?ia A.A. I?inoaiieaeu. Iniiau oeceieiaee. / Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, “Eoaaiue”, 1998, n.74-79. 4. ?aa?ia A.A., Ieioeei A.ss., Oai/aiei O.N. Iaiai yeaeo?ieeoia e o?iaaiue eeoai/eiaie oeeueo?aoeee / Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, “Eoaaiue”, 1998, n.23-36. 5. Ninoiyiea ?AAN o ?aai/eo eienioeie/aneiai i?iecaiaenoaa / A.A.?aa?ia, A.ss.Ieioeei, O.N.Oai/aiei, ss.A.A?ucoiiaa, N.I.Euia?ue // Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, “Eoaaiue”, 1998, n.44-51. 6. ?aa?ia A.A., Ieioeei A.ss., Oai/aiei O.N. Niaea?aeaiea aacii?anneia a ieacia e?iae ?aai/eo eienioeie/aneiai i?iecaiaenoaa. / Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia / Eoaaine, “Eoaaiue”, 1998, n.57-59. 7. ?aa?ia A.A., Ieioeei A.ss. Auaeaeaiea i?inoaiieaeia n ii/ae o ?aai/eo eienioeie/aneiai i?iecaiaenoaa. /Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, “Eoaaiue”, 1998, n.79-87. 8. Aeeyiea yeciaaiiie aeia?oa?iee ia ii?oieiae/aneoth no?oeoo?o ii/ae e ia/aie. / A.A.?aa?ia, A.ss.Ieioeei, A.I.Iiaaaeaiiay I.A.No?ieei, I.E.Ieoeoiae // Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, “Eoaaiue”, 1998, n.116-130. 9. ?aa?ia A.A., Ieioeei A.ss.,.Ieeeoeia E.A Ii/aauaeaeeoaeueiay nenoaia. / Eienioeie/aneee caaiae e caaieaaaiey aioo?aiieo i?aaiia / Iiae. ?aae. A.ss.Ieioeeia/ Eoaaine, “Eoaaiue”, 1998, n.144-153. 10. ?aa?ia A.A., Ieioeei A.ss. Ii?aaeaeaiea aeueaeinoa?iia, o?iiaienaia A2 e i?inoaoeeeeeia a aeieiae/aneeo aeeaeeinoyo // Eaai?aoi?iia aeaei.- 1991.- N 8.- N.27-30. 11. ?aa?ia A.A., Ieioeei A.ss. Aeeyiea aic?anoa e noaaea ?aaiou ia ninoiyiea ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu e neioac i?inoaaeaiaeeiia o ai?ii?aai/eo oaieueiuo oaoo // Iaaeeoeeia o?oaea e i?iiuoeaiiay yeieiaey.- 1995.- N 6.- N. 15-17. 12. ?aa?ia A.A. Eciaiaiey ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu e aiaeii-nieaaiai iaiaia o ai?ii?aai/eo oaieueiuo oaoo // A?a/aaiia aeaei.- 1996.- N 7-9.- N.89-92. 13. I?ioeeaeoeea caaieaaaaiinoe o ?aai/eo, caiyouo aeiau/ae e ia?a?aaioeie oaey /A.A.?aa?ia, A.E.Ee?eeaiei, I.A.No?ieei, N.A.Nieieiaa, I.E.Oea/aiei // Io?aia i?aoe?.- 1997.- N 7.- N.8. 14. ?aa?ia A.A. Aiciiaeiua iaoaieciu ?acaeoey i?ioaeio?ee iai?yaeaiey o i?aeoe/anee caei?iauo ?aai/eo // Iao?ieiaey.- 1997.- ?3.- N.46-50. 15. ?aa?ia A.A. Iaeioi?ua iaoaieciu iinoiaa?oci/iie aaiaoo?ee o iiaecaiiuo ai?ii?aai/eo oaieueiuo oaoo // Iao?ieiaey.-1997.-N 4.-N.55-59. 16. ?aa?ia A.A. Eciaiaiey eiioiiiai noaoona o iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo // Aanoiee i?iaeai aeieiaee e iaaeeoeeiu.- 1997.- ? 32.-N.73-77. 17. ?aa?ia A.A. Iinoiaa?oci/iay aaiaoo?ey o i?aeoe/anee caei?iauo oaooa?ia // O?ieiaey e iao?ieiaey.- 1997.- ? 5.- N.9-11. 18. IAOAIO ia aeiao?ae UA 21063 IEE A61 E35/80, Niin?a i?io?-eaeoeee caoai?thaaiue eaaai?a oa aa?oi?o aeeoaeueieo oeyo?a / A.I.?aa?ia, A.ss.Ieioe?i, I.?.I?oeoiae; cayaeaii 11.03.97, iioae. 01.98.- 4 n. 19. ?aa?ia A.I., Ieioe?i A.ss., I?e?o?ia ?.A. Ooaaeueia ??oaiiy i?i iaaeaiiy iaoaioo ia aeiao?ae Niin?a i?io?eaeoeee caoai?thaaiue aa?oi?o aeeoaeueieo oeyo?a.- ? 98010098/A a?ae 8.01.98. 20. ?aa?ia A.A., A.ss.Ieioeei, I.E.Ieoeoiae Ii?oieiae/aneea eciaiaiey ia/aie i?e ino?ii e o?iie/aneii ia?aa?aaaiee // Oe?a?inueeee iaaee/iee aeueiaiao.- 1998.- O.1, ?3.- N.56-59. 21. ?aa?ia A.A., Euia?ue N.I. Aeeyiea noaaea ?aaiou a aeoaieeo oaieueiuo oaooao ia ninoiyiea oeaio?aeueiie aaiiaeeiaieee e aeoeaiinoe ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu o ?aai/eo. // A?niee i?iaeai a?ieia?? ? iaaeeoeeie.- 1998.- ?19.- N.8-11. 22. ?aa?ia A.I. Iniaeeaino? aaiaoo??? i?ney iaaaioaaeaiiy o i?aecaiieo a??iee?a aoa?eueieo oaoo // Oe?a?inueeee iaaee/iee aeueiaiao.- 1998.- O.1, ?4.- N.33-35. 23. I?eiaiaiea nie?oeeiu a oeaeyo i?ioeeaeoeee ino?uo i?inooaeiuo caaieaaaiee o oaooa?ia / A.A.?aa?ia, A.ss.Ieioeei, I.E.Ieoeoiae, E.A.Ieeeoeia // A?niee i?iaeai a?ieia?? ? iaaeeoe?ie.- 1998.- ?24.- N.98-101. 24. ?aa?ia A.A., Ieioeei A.ss., Ieoeoiae I.E. Aeeyiea ino?iai e o?iie/aneiai ia?aa?aaaiey ia ii?oieiae/aneea eciaiaiey ia/aie // E?ea?nueea ni?aaa. - 1998. - ?8. – N.85-88. 25. ?aa?ia A.I., Ieioe?i A.ss., I?e?o?ia ?.A Ii?oieia?/i? aea?aaeaioe ?icaeoeo i?ioa?io??? i?ae aieeaii ia?aa??aaiiy // Oe?a?inueeee iaaee/iee aeueiaiao.- 1999.- O.2, ?1.- N.44-48. 26. ?aa?ia A.A. Iniaaiiinoe iaoiaaiaca ?acaeoey caaieaaaiee ia/aie o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo // Oe?a?inueeee iaaee/iee aeueiaiao.- 1999.- O.2, ?2.- N.180-183. 27. ?aa?ia A.A., Euia?ue N.I. Iniaaiiinoe eiioiiiai noaoona e ia?aeeniiai ieeneaiey eeieaeia o iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo // E?ea?nueea ni?aaa. - 1999. - ?4. – N.162-165. 28. ?aa?ia A.A., Euia?ue N.I., Ieeeoeia E.A. Eciaiaiey oeaio?aeueiie aaiiaeeiaieee e aeoeaiinoe ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu o oaooa?ia // Iao.XIV c’?caeo oa?aiaao?a Oe?a?ie Ee?a, 1998.-N.228-229. 29. ?aa?ia A.I., I?oeoiae I.?. Ci?ia a?io?i?/ieo iieaciee?a ia/?iee o a??iee?a aeeaieeo aoa?eueieo oaoo Aeiiaano. // Iao. XIV c’?caeo oa?aiaao?a Oe?a?ie. Ee?a, 1998.- N.410-413. 30. ?aa?ia A.I., Ieioe?i A.ss., I?e?o?ia ?.A. I?ioa?io??y iai?oaeaiiy o i?aeoe/ii caei?iaeo a??iee?a aoa?eueieo oaoo. // Iao. XIV c’?caeo oa?aiaao?a Oe?a?ie. Ee?a, 1998.- N.505-508. 31. ?aa?ia A.A., Ieioeei A.ss., Ao?iae TH.A. Aeeyiea oyaeaeiai oece/aneiai o?oaea a oneiaeyo oaieueiie oaoou ia ninoiyiea ?aiei-aiaeioaicei-aeueaeinoa?iiiaie nenoaiu, neioac i?inoaaeaiaeeiia e aiaeii-nieaaie iaiai: Na. iao/i. o?. "Yeieiaey i?iiuoeaiiiai ?aaeiia Aeiiaanna".- Eoaaine, 1993, n. 129-133. 32. ?aa?ia A.A. E aii?ino i ?iee neioaca i?inoaaeaiaeeiia a ii/eao a ?acaeoee i?ioaeio?ee o oaooa?ia: Na. iao/.o?. "Yeieiae/aneea i?iaeaiu e?oiiiai i?iiuoeaiiiai ?aaeiia aeacaie a?a/a".- Eoaaine.- 1993.- N.50-51. 33. Ie?oaeathuay n?aaea eae oaeoi? ?enea ii?aaeaiey ii/ae e ?acaeoey aeia?oiiee / A.A.?aa?ia, A.ss.Ieioeei, TH.A.Ao?iae, A.I.Iiaaaeaiiay : Na. o?oaeia III aaeaaiaei. N-Iaoa?ao?ane. naieia?a.- N-Iaoa?ao?a, 1995.- N.67-70. 34. ?aa?ia A.A. Aeeyiea oyaeaeiai oece/aneiai o?oaea a oneiaeyo oaieueiie oaoou ia neioac i?inoaiieaeia a ii/eao: THa?eaeiee ca. i?. iieiaeeo a/aieo oa niaoe?ae?no?a.- Eoaaine, 1996.- N.131-132. 35. Oneeaiea i?ioeannia ia?aeeniiai ieeneaiey eeieaeia, eae oaeoi? ?enea ii?aaeaiey ia/aie o iiaecaiiuo ai?ii?aai/eo aeoaieeo oaieueiuo oaoo / A.A.?aa?ia, A.ss.Ieioeei, A.I.Iiaaaeaiiay, I.E.Ieoeoiae // Iaaeeei aeieia?/i? i?iaeaie i?iieneiaiai ?aa?iio: Ca. Iaoe. i?. - Eoaainuee: EAeIO.- 1997.- N. 160-163. 36. Rebrov B.A., Plotkin V.J., Environmental and Occupation Influences on Renal Function // 9th Asian Colloqium in Nephrology, Seul, Korea.- 1992.- ?. 2-06. 37. Plasma renin activity (RA) alterations, aldosteron (A), prostanoid and electrolyte disturbancts as risk factors of the cardiovascular diseases in coke-chemical workers//B.A.Rebrov, V.J.Plotkin, Y.G.Burmak, T.S.Temchenko// 3rd International Conference on Preventive Cardiology.- Oslo.- 1993.- P. O 160. 38. Influence of hot environment on renal structures and functions / B.A.Rebrov, V.J.Plotkin, Y.G.Burmak, G.P.Pobedionnaja // XIIIth Int.Congr. Nephrol.- Madrid.- 1995.- Abstr.96. 39. Rebrov B.A., Plotkin V.J., Burmak J.G. Risk factors of the hypertension in coke-chemical workers // World conference of Hypertension Control.Abstr.- Ottawa, Canada.- 1995.- ?.198. 40. Envaironment renal functions disturbans as risk faktors of hipertension / B.A.Rebrov, V.J.Plotkin, Y.G.Burmak, G.P.Pobedionnaja // XXXIIrd Congress of the EDTA Europ. Renal Association, Greece Abstr.- Athens.- 1995.- ?. O 262. AIIOAOe?ss ?aa?ia A.I. Iaoai?cie ?icaeoeo caoai?thaaiue ia/?iee ? ie?ie o a??iee?a aeeaieeo aoa?eueieo oaoo Aeiiaano oa iiaeeea? oeyoe ?o i?io?eaeoeee.- ?oeiien. Aeena?oaoe?y ia caeiaoooy iaoeiaiai nooiaiy aeieoi?a iaaee/ieo iaoe ca niaoe?aeuei?noth 14.01.02 - aioo??oi? oai?iae. Oa?e?anueeee aea?aeaaiee iaaee/iee oi?aa?neoao, Oa?e?a, 1999. Aeena?oaoe?y i?enay/aia aea/aiith iaoai?ci?a ?icaeoeo caoai?thaaiue ia-/?iee ? ie?ie o a??iee?a. Anoaiiaeai? ii?ooaiiy ooieoe?? ia/?iee, iaea?eueo ae?aaeai? o iieiaeeo ?ia?oiee?a. Aeyaeai? iaoai?cie aeieeiaiiy i?ioa?io??? iai?oaeaiiy oa aaiaoo??? i?ney iaaaioaaeaiiy ia iniia? aea/aiiy ia?aeeniiai ieeneaiiy e?i?ae?a, ?ioiiiai noaoono, ?ai?i-aia?ioaicei-aeueaeinoa?iiiai? nenoaie, aacii?aneio, aiaeioae?io-1, neioaco i?inoaaeaiaeei?a, aiaeii-nieueiaiai iai?io oa aaiiaeeiai?ee. Iieacai? oeueo?ano?oeoo?i? ?ic??ciaiiy ?aaeoe?? ee?oei ia/?iee ? i?ieneiaeueieo eaiaeueoe?a ie?ie ia ia?aa??aaiiy, iiaeai? aeaeo?iiiia?noio?i?/i? e?eoa??? ?o ?ici?ciaaaiiy. Anoaiiaeaii i?aeneeaiiy ia?aeeniiai ieeneaiiy e?i?ae?a ? aeoeaiino? oa?iaio?a aioeieneaeaioiiai caoenoo, a oaeiae iayai?noue ?ioiiaeao?oeeoiiai noaio, a ?icaeoeo yeiai i?eeia? o/anoue ai?iii oeiono a1-oeiicei. Cai?iiiiiaai? iaoiaaiaoe/ii iaa?oioiaai? niiniae ei?aeoe?? aeyaeaieo ii?ooaiue. Eeth/ia? neiaa: a??ieee, ie?ee, ia/?iea, i?ioa?io??y, aaiaoo??y, ?ai?i, aeueaeinoa?ii, i?inoaaeaiaeeie, aiaeioae?i, aaiiaeeiai?ea, e?iiia?ieneaeaoe?y, ?ioi?oao, oeiicei. Rebrov B.A. Mechanisms of development liver and kidney diseases of the colliers of deep coal mines of Donbass and pathes of their profilactis.-Manuscript. Thesis for a doctor’s degree by speciality 14.01.02 - internal diseases.- Kharkov State Medical University, Kharkov, 1999. The thesis is dedicated to analysis of mechanisms of development liver and kidney diseases in the colliers. The disturbance of liver function a most expressed for young working are established. The mechanisms of appearing of a proteinuria and hematuria arising after a working shift are detected on the basis of analysis of lipids peroxidation, immune status, renin-angiotensin-aldosterone system, vasopressin, endotelin-1, synthesis of prostaglandins in the kidney, water-salt metabolism, and hemodynamics. The ultrastructural distinctions of reactions of cells of liver and proximal tubules of kidney on a superheating are rotined and the electronic - histochemical criterions of their recognition are given. The increasing of processes of lipids peroxidation and enzymes of antioxidant protection is established, and also the presence of immunounprofitable condition, in which development hormonum a1-timosinum shares. The pathogenetic justified ways of correction of the detected disturbance are offered. Key words: the colliers, kidneys, liver, proteinuria, hematuria, renin, aldosteronum, prostaglandinums, endotelin, hemodynamics, lipids peroxidation, immunity, timosinum. ?aa?ia A. A. Iaoaieciu ?acaeoey caaieaaaiee ia/aie e ii/ae o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo Aeiiaanna e aiciiaeiua iooe eo i?ioeeaeoeee.-?oeiienue. Aeenna?oaoeey ia nieneaiea o/aiie noaiaie aeieoi?a iaaeeoeeineeo iaoe ii niaoeeaeueiinoe 14.01.02 - aioo?aiiea aieacie.- Oa?ueeianeee ainoaea?noaaiiue iaaeeoeeineee oieaa?neoao, Oa?ueeia, 1999. Aeenna?oaoeey iinayuaia eco/aieth iaoaieciia ?acaeoey caaieaaaiee ia/aie e ii/ae o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo e ?ac?aaioea niiniaia eo i?ioeeaeoeee. A ?aaioa aeaiu ?acoeueoaou eiiieaeniiai eco/aiey ?aiieo ia?ooaiee ooieoeeiiaeueiiai ninoiyiey ia/aie e ii/ae, a oaeaea ninoiyiey ia?aeeniiai ieeneaiey eeieaeia, nenoaiu aioeieneaeaioiie caueou e eiioiiiai noaoona o i?aeoe/anee caei?iauo ai?ii?aai/eo. I?e yoii onoaiiaeaiu ia?ooaiey ooieoeee ia/aie, au?aaeathueany a nieaeaiee niaea?aeaiey aeueaoieiia a nuai?ioea e?iae, iniaaiii cia/eoaeueiua o iieiaeuo ai?ii?aai/eo e ai?ii?aai/eo n iiaecaiiui noaaeai aei 5 eao; ioiineoaeueiii iiauoaiee o?iaiae o?ainaieiac, o?iaiy oieanoa?eia e -eeiii?ioaeaeia a nuai?ioea e?iae, i?aeiouanoaaiii o ?aai/eo iniiaiuo i?ioannee, auiieiythueo oyaeaeua ?aaiou a iaaeaaii?eyoiuo oneiaeyo ai?iuo au?aaioie. Auyaeaii, /oi a?oiiie ?enea ?acaeoey caaieaaaiee ia/aie yaeythony ?aai/ea a aic?anoa 20-30 eao e eeoea n iiaecaiiui noaaeai aei 5 eao, iaeaieaa iiaeaa?aeaiiua aicaeaenoaeth a?aaeiuo oaeoi?ia aeoaieie oaieueiie oaoou. Aia?aua auyaeaii cia/eoaeueiia nieaeaiea o?iaiy ai?iiia oeiona a1-oeiiceia o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo, e ii?aaeaeaia aai ?ieue a ?acaeoee eiioiiaeaoeoeeoiiai ninoiyiey o ai?ii?aai/eo. Onoaiiaeaii, /oi oaeoi?aie ?enea ?acaeoey caaieaaaiee ii/ae yaeythony au?aaeaiiua ia?ooaiey aiaeii-nieaaiai iaiaia, nii?iaiaeaeathueany eciaiaieai aeoeaiinoe ?AAN, aacii?anneia ieaciu e?iae, neioaca i?inoaiieaeia, e oeaio?aeueiie aaiiaeeiaieee, a caaeneiinoe io oyaeanoe auiieiyaiuo ?aaio, aic?anoa e noaaea ?aaiou. Ii?aaeaeaii iiauoaiea o?iaiy yiaeioaeeia-1 a ieacia e?iae o ai?ii?aai/eo a caaeneiinoe io oyaeanoe auiieiyaiuo ?aaio. Aia?aua i?aaeeiaeaia aeiioaca ?acaeoey i?ioaeio?ee iai?yaeaiey o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo. Aia?aua auyniaiu iaoaieciu ?acaeoey iinoiaa?oci/iie aaiaoo?ee, aicieeathuae i?e eciaiaieyo ANI, iiauoaiee aeoeaiinoe ?AAN e neioaca o?iiaienaia a ii/eao, i?e iieiii ia?ooaiee acaeiinayce iaaeaeo eco/aaiuie ?aaoeyoi?iuie nenoaiaie. Aia?aua iieacaiu oeueo?ano?oeoo?iua ?acee/ey ?aaeoeee eeaoie ia/aie e i?ieneiaeueiuo eaiaeueoeaa ii/ae ia ia?aa?aaaiea e aeaiu yeaeo?iiii-iee?ineiie/aneea e yeaeo?iiiiaenoioeie/aneea e?eoa?ee eo ?aniiciaaaiey. Aia?aua iieacaia aeeiaieea ia?ooaiee IIE e nenoaiu aioeieneaeaioiie caueou, a oaeaea ?acaeoea aoi?e/iiai eiioiiaeaoeoeeoiiai ninoiyiey a caaeneiinoe io oyaeanoe o?oaea e noaaea ?aaiou ai?ii?aai/eo e eo ?ieue a ?acaeoee caaieaaaiee ia/aie e ii/ae. I?aaeeiaeaia noaia iaoiaaiaca ?acaeoey caaieaaaiee ia/aie o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo. ?ac?aaioaiu e ai?iae?iaaiu iiaua, iaoiaaiaoe/anee iainiiaaiiua, iaoiaeu i?ioeeaeoeee caaieaaaiee ia/aie e ii/ae o ai?ii?aai/eo, caeeth/athueany a eniieueciaaiee i?aia?aoia “Nie?oeeia”, “Aiecii” e “Aio?aeue”. ?acoeueoaou enneaaeiaaiee iiaeii oe?iei eniieueciaaoue a i?aeoe/aneii cae?aaiio?aiaiee. Aaaaeaiea eiiieaeniiai enneaaeiaaiey ooieoeeiiaeueiiai ninoiyiey ia/aie, na?aea/ii-ninoaeenoie e ii/aauaeaeeoaeueiie nenoai ai a?aiy i?ioeeaeoe/aneeo iniio?ia ai?ii?aai/eo aeoaieeo oaieueiuo oaoo iicaieyao auyaeoue a?oiio eeoe n iiauoaiiui ?eneii ?acaeoey iaoieiaee yoeo i?aaiia, ?ac?aaioaoue i?ia?aiio aeeniaina?iiai iaaethaeaiey, i?ioeeaeoe/aneiai ea/aiey e ?aoeeiiaeueiiai o?oaeiono?ienoaa. ?aiiaa auyaeaiea ?aai/eo n iiyaeaieai i?ioaeio?ee iai?yaeaiey e iinoiaa?oci/iie aaiaoo?ee e ei??aeoeey yoeo ninoiyiee iicaieyao i?aaeioa?aoeoue ?acaeoea caaieaaaiee ii/aauaeaeeoaeueiie nenoaiu. Iiauoaiea aieiaiey a?a/ae e iieiaeui ?aai/ei (20-30 eao) e eeoeai n iaaieueoei iiaecaiiui noaaeai (aei 5 eao), aua ia aaeaioe?iaaiiui e oneiaeyi aeoaieie oaieueiie oaoou, iicaieeo nieceoue caaieaaaaiinoue e cia/eoaeueii iiauneoue eo o?oaeiniiniaiinoue. Eniieueciaaiea iieo/aiiuo aeaiiuo i ?iee aeanoaaeeecaoeee eeciniiaeueiuo iaia?ai eae i?e/eiu ?acaeoey iae?icia a eeaoeao ia/aie e ii/ae, ia?ooaieyo IIE, aioeieneaeaioiie nenoaiu e eiioiiiai noaoona iicaieyao aeeth/eoue a eiiieaen i?ioeeaeoe/aneeo ia?ii?eyoee i?aia?aou “Nie?oeeia”, “Aio?aeue” e “Aiecii”, iaeaaeathuea iaia?aiinoaaeeece?othuei, aioeieneaeaioiui e eiioiiiiaeoee?othuei aeaenoaeai. I?eiaiaiea iiauo niiniaia i?ioeeaeoeee caaieaaaiee ia/aie e ii/ae o ai?ii?aai/eo aeoaieeo oaieueiuo oaoo e ?aoeeiiaeueiia o?oaeiono?ienoai i?aaeioa?auaao ?acaeoea ia?ooaiee eo ooieoeeiiaeueiiai ninoiyiey e niinianoaoao caiaaeeaieth oaiiia ?acaeoey caaieaaaiee. Eeth/aaua neiaa: ai?ii?aai/ea, ii/ee, ia/aiue, i?ioaeio?ey, aaiaoo?ey, ?aiei, aeueaeinoa?ii, i?inoaaeaiaeeiu, yiaeioaeei, aaiiaeeiaieea, eeiiia?ieneaeaoeey, eiioieoao, oeiicei.

Добавить комментарий

Ваш e-mail не будет опубликован. Обязательные поля помечены *